{ "uniprot_canonical_ac": "A0A0G2JWH3-1", "sequence": { "header": "tr|A0A0G2JWH3-1|A0A0G2JWH3_RAT Isoform 1 of Condensin complex subunit 1 OS=Rattus norvegicus OX=10116 GN=Ncapd2 PE=1 SV=1 CANONICAL=A0A0G2JWH3-1", "length": 1389, "sequence": "MSPHNFEFHLPLSPEELLKSRGVNQYVVQEVLPIKHLPTQLRAFQSAFRAQGPLAILDHFDTIYSIIHHFRSIEPGLKEDTLEFLMKVVSCHSQELSSILDDAALSGSDRSAHLNALKMNCYALIRLLESFENMTSQTGLIDLDIGGKGKKARAKTALGFVWEEERQPVLELLTQLLQLDIRHLWSHSVIEEEFVSLVTGCCYRLLENPTISHQKNRSTKEAIAHLLGVALVRYNHMLSATVKIIQMLQHFEHLPSVLVAAVTLWATDYGMKSIVGEIVREIGQKCPQEMSRDTAGAKGFAAFLTELAERIPAALMSSMCMLLDHLDGENYMMRNAVLAAMAEMILQVLNGDQLEESARETRDQFLDILQAHGHDVNSFVRSRVLQLFTRIVQQKALPLTRFQAVVALAVGRLADKSVLVCKNAIQLLASFLANNPFSCKLSDTDLAGPLQKEIQKLQEMRAQRRTAAASAALDSEEEWEAMLPELKSTVQQLLKLPQEEAEQQIADGETAEEVKGRIHQLLARASYKQAILLTREATSRFQESEPFSHTEPEEKDFLNLLGVIFKGPEASTHESPRHTDPGLTGSKDSPSVPEPEGSQRDDELLKQEMLVQYLQDAYSFSQKITEAIGVISKMMYENTTTVVQEVIEFFVMVFQFGVPQALFGVRRMLPLIWSKELGVREAVLNAYRQLYLSPKGDSARATAQALIQNLSLLLVDASVGTIQCLEEILCEFVQKDEIKPAVIQLLWERATEKVPCSPLERCSSVMLLGMMARGKPEIVGSNLDTLVKVGLDEKFPQDYRLAQQVCLAIANISDRRKPSLGERHPPFRLPQEHKLFERLQEMVTKGFAHPDPFWIPFKEVAVTLTYLAEGPDVICSQMLQGCAKQALEKLEKNTTEGDSKETAPKLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELGRRRVLREEQEHRTKVPKEKTTSSETTMEEELGLVGATADDTEAELVRSICEKELLDGTQVLAAFVPLLLKVCNNPGAYSNPELSAAASLALGKFCMISAPFCDSQLRLLFTMLEKSSLPTVRSNLMVATGDLAIRFPNLVDPWTPHLYARLRDPAQQVRRTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPVPQIAALAKNFFNELSHKGNAIYNLLPDIISRLSDPEGGVGEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTARTERQYRDLAYCVSQLPLTERGLHKMLDNFDCFGDKLIDESVFSAFLSIVGKLRRGAKPEGKAVIDEFEQKLRACHTRGMDGIEELETGQGGSQRALSAKKPSAVSRQQPLTSVDSDNDFVTPKPRRTKPRRPQTQQRKSQRKAKVVFSSDESSEDELSAEMTEEETPKKTTPIRRASAQRHRS" }, "uniprot_id": "A0A0G2JWH3_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [], "uniprotkb": [ "Condensin complex subunit 1" ] }, "gene": { "refseq": [], "uniprotkb": [ "Ncapd2" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3", "id": "A0A0G2JWH3", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Condensin complex subunit 1." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3/publications", "id": "A0A0G2JWH3", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3#A0A0G2JWH3-1", "isoform_ac": "A0A0G2JWH3-1", "locus": { "end_pos": 157683080, "start_pos": 157704596, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000083016", "id": "ENSRNOT00000083016", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000069882", "id": "ENSRNOP00000069882", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JWH3-1|A0A0G2JWH3_RAT Isoform 1 of Condensin complex subunit 1 OS=Rattus norvegicus OX=10116 GN=Ncapd2 PE=1 SV=1 CANONICAL=A0A0G2JWH3-1", "length": 1389, "sequence": "MSPHNFEFHLPLSPEELLKSRGVNQYVVQEVLPIKHLPTQLRAFQSAFRAQGPLAILDHFDTIYSIIHHFRSIEPGLKEDTLEFLMKVVSCHSQELSSILDDAALSGSDRSAHLNALKMNCYALIRLLESFENMTSQTGLIDLDIGGKGKKARAKTALGFVWEEERQPVLELLTQLLQLDIRHLWSHSVIEEEFVSLVTGCCYRLLENPTISHQKNRSTKEAIAHLLGVALVRYNHMLSATVKIIQMLQHFEHLPSVLVAAVTLWATDYGMKSIVGEIVREIGQKCPQEMSRDTAGAKGFAAFLTELAERIPAALMSSMCMLLDHLDGENYMMRNAVLAAMAEMILQVLNGDQLEESARETRDQFLDILQAHGHDVNSFVRSRVLQLFTRIVQQKALPLTRFQAVVALAVGRLADKSVLVCKNAIQLLASFLANNPFSCKLSDTDLAGPLQKEIQKLQEMRAQRRTAAASAALDSEEEWEAMLPELKSTVQQLLKLPQEEAEQQIADGETAEEVKGRIHQLLARASYKQAILLTREATSRFQESEPFSHTEPEEKDFLNLLGVIFKGPEASTHESPRHTDPGLTGSKDSPSVPEPEGSQRDDELLKQEMLVQYLQDAYSFSQKITEAIGVISKMMYENTTTVVQEVIEFFVMVFQFGVPQALFGVRRMLPLIWSKELGVREAVLNAYRQLYLSPKGDSARATAQALIQNLSLLLVDASVGTIQCLEEILCEFVQKDEIKPAVIQLLWERATEKVPCSPLERCSSVMLLGMMARGKPEIVGSNLDTLVKVGLDEKFPQDYRLAQQVCLAIANISDRRKPSLGERHPPFRLPQEHKLFERLQEMVTKGFAHPDPFWIPFKEVAVTLTYLAEGPDVICSQMLQGCAKQALEKLEKNTTEGDSKETAPKLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELGRRRVLREEQEHRTKVPKEKTTSSETTMEEELGLVGATADDTEAELVRSICEKELLDGTQVLAAFVPLLLKVCNNPGAYSNPELSAAASLALGKFCMISAPFCDSQLRLLFTMLEKSSLPTVRSNLMVATGDLAIRFPNLVDPWTPHLYARLRDPAQQVRRTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPVPQIAALAKNFFNELSHKGNAIYNLLPDIISRLSDPEGGVGEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTARTERQYRDLAYCVSQLPLTERGLHKMLDNFDCFGDKLIDESVFSAFLSIVGKLRRGAKPEGKAVIDEFEQKLRACHTRGMDGIEELETGQGGSQRALSAKKPSAVSRQQPLTSVDSDNDFVTPKPRRTKPRRPQTQQRKSQRKAKVVFSSDESSEDELSAEMTEEETPKKTTPIRRASAQRHRS" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2514853", "resource": "Reactome", "id": "R-RNO-2514853", "name": "Condensation of Prometaphase Chromosomes" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3#function", "annotation": "Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3#function", "id": "A0A0G2JWH3", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q15021-1", "protein_name": "Condensin complex subunit 1; Chromosome-associated protein D2; hCAP-D2; Chromosome condensation-related SMC-associated protein 1; Non-SMC condensin I complex subunit D2; XCAP-D2 homolog.", "sequence": { "length": 1401, "sequence": "MAPQMYEFHLPLSPEELLKSGGVNQYVVQEVLSIKHLPPQLRAFQAAFRAQGPLAMLQHFDTIYSILHHFRSIDPGLKEDTLQFLIKVVSRHSQELPAILDDTTLSGSDRNAHLNALKMNCYALIRLLESFETMASQTNLVDLDLGGKGKKARTKAAHGFDWEEERQPILQLLTQLLQLDIRHLWNHSIIEEEFVSLVTGCCYRLLENPTINHQKNRPTREAITHLLGVALTRYNHMLSATVKIIQMLQHFEHLAPVLVAAVSLWATDYGMKSIVGEIVREIGQKCPQELSRDPSGTKGFAAFLTELAERVPAILMSSMCILLDHLDGENYMMRNAVLAAMAEMVLQVLSGDQLEAAARDTRDQFLDTLQAHGHDVNSFVRSRVLQLFTRIVQQKALPLTRFQAVVALAVGRLADKSVLVCKNAIQLLASFLANNPFSCKLSDADLAGPLQKETQKLQEMRAQRRTAAASAVLDPEEEWEAMLPELKSTLQQLLQLPQGEEEIPEQIANTETTEDVKGRIYQLLAKASYKKAIILTREATGHFQESEPFSHIDPEESEETRLLNILGLIFKGPAASTQEKNPRESTGNMVTGQTVCKNKPNMSDPEESRGNDELVKQEMLVQYLQDAYSFSRKITEAIGIISKMMYENTTTVVQEVIEFFVMVFQFGVPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLNPKGDSARAKAQALIQNLSLLLVDASVGTIQCLEEILCEFVQKDELKPAVTQLLWERATEKVACCPLERCSSVMLLGMMARGKPEIVGSNLDTLVSIGLDEKFPQDYRLAQQVCHAIANISDRRKPSLGKRHPPFRLPQEHRLFERLRETVTKGFVHPDPLWIPFKEVAVTLIYQLAEGPEVICAQILQGCAKQALEKLEEKRTSQEDPKESPAMLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELCRRRVLREEQEHKTKDPKEKNTSSETTMEEELGLVGATADDTEAELIRGICEMELLDGKQTLAAFVPLLLKVCNNPGLYSNPDLSAAASLALGKFCMISATFCDSQLRLLFTMLEKSPLPIVRSNLMVATGDLAIRFPNLVDPWTPHLYARLRDPAQQVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPEPQIAALAKNFFNELSHKGNAIYNLLPDIISRLSDPELGVEEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTSRTERQQRDLAYCVSQLPLTERGLRKMLDNFDCFGDKLSDESIFSAFLSVVGKLRRGAKPEGKAIIDEFEQKLRACHTRGLDGIKELEIGQAGSQRAPSAKKPSTGSRYQPLASTASDNDFVTPEPRRTTRRHPNTQQRASKKKPKVVFSSDESSEEDLSAEMTEDETPKKTTPILRASARRHRS" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2JWH3/", "id": "A0A0G2JWH3", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3", "id": "A0A0G2JWH3", "database": "UniProtKB" } ], "name": "chromatin binding", "id": "GO:0003682" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3", "id": "A0A0G2JWH3", "database": "UniProtKB" } ], "name": "histone binding", "id": "GO:0042393" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000799", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3", "id": "A0A0G2JWH3", "database": "UniProtKB" } ], "name": "nuclear condensin complex", "id": "GO:0000799" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000779", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3", "id": "A0A0G2JWH3", "database": "UniProtKB" } ], "name": "condensed chromosome, centromeric region", "id": "GO:0000779" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3", "id": "A0A0G2JWH3", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3", "id": "A0A0G2JWH3", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007076", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3", "id": "A0A0G2JWH3", "database": "UniProtKB" } ], "name": "mitotic chromosome condensation", "id": "GO:0007076" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010032", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3", "id": "A0A0G2JWH3", "database": "UniProtKB" } ], "name": "meiotic chromosome condensation", "id": "GO:0010032" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051304", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3", "id": "A0A0G2JWH3", "database": "UniProtKB" } ], "name": "chromosome separation", "id": "GO:0051304" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3", "id": "A0A0G2JWH3", "database": "UniProtKB" } ], "name": "cell division", "id": "GO:0051301" } ], "total": 4, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 135, "annotation": "n_glycosylation_sequon", "start_pos": 133 }, { "end_pos": 218, "annotation": "n_glycosylation_sequon", "start_pos": 216 }, { "end_pos": 640, "annotation": "n_glycosylation_sequon", "start_pos": 638 }, { "end_pos": 711, "annotation": "n_glycosylation_sequon", "start_pos": 709 }, { "end_pos": 813, "annotation": "n_glycosylation_sequon", "start_pos": 811 }, { "end_pos": 895, "annotation": "n_glycosylation_sequon", "start_pos": 893 } ], "crossref": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2514853", "id": "R-RNO-2514853", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000055300", "id": "ENSRNOG00000055300", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/RNCVLQI/", "id": "RNCVLQI", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032682", "id": "IPR032682", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "id": "IPR011989", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "id": "IPR016024", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR024324", "id": "IPR024324", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007673", "id": "IPR007673", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR026971", "id": "IPR026971", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF12717", "id": "PF12717", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF12922", "id": "PF12922", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14222", "id": "PTHR14222", "database": "PANTHER" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14222:SF2", "id": "PTHR14222:SF2", "database": "PANTHER" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1562596", "id": "1562596", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2JWH3", "disease": [], "mass": { "monoisotopic_mass": 155462.0, "chemical_mass": 155462.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3", "name": "Ncapd2.", "locus": { "end_pos": 157683077, "start_pos": 157704596, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000055300", "id": "ENSRNOG00000055300", "database": "Ensembl Gene" } ] } } ] }