{ "uniprot_canonical_ac": "A0A0G2JVC1-1", "sequence": { "header": "tr|A0A0G2JVC1-1|A0A0G2JVC1_RAT Isoform 1 of E3 ubiquitin-protein ligase Mdm2 OS=Rattus norvegicus OX=10116 GN=Mdm2 PE=1 SV=1 CANONICAL=A0A0G2JVC1-1", "length": 483, "sequence": "MCNTNMSVSTEGAAGTSQIPASEQETLVRPKPLLLKLLKSVGAQKDIYTMKEIIFYIGQYIMTKRLYDEKQQHIVYCSNDLLGDVFGVPSFSVKEHRKIYAMIYRNLVVVSQQDSGTSPSESRCQPEGGSDLKDPVQASQEEKPSSSDVVSRPSTSSRRRAISETEENTDELPGERQRKRHRALSFDESLGLCVLREICCERSSSSEATDTPSHQDLDDGVSDHSADCLDQDSVSDQFSVEFEVESLDSEDYSLSDEGHELSDEDDEVYRVTVYQAGESDADSFEGDPEISLADYWKCTSCNEMNPPLPSHCNRCWTLRENWLPDDKGKDKVEISEKAKLESSDQAEEGLDVPDGKKVTEDDAKESSAEDSEEKVAQMLLSQESDDYSQPSTSSSIVYSSQESGKELKEDTQDKEESMESSFSLNAIEPCVICQGRPKNGCIVHGKTGHLMSCFTCAKKLKKRNKPCPVCRQPIQMIVLTYFN" }, "uniprot_id": "A0A0G2JVC1_RAT", "enzyme_annotation": [ { "ec": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine." }, { "ec": "2.3.2.27", "activity": "" } ], "synonyms": { "protein": { "refseq": [ "E3 ubiquitin-protein ligase Mdm2 isoform X2" ], "uniprotkb": [ "E3 ubiquitin-protein ligase Mdm2", "2.3.2.27" ] }, "gene": { "refseq": [ "Mdm2" ], "uniprotkb": [ "Mdm2" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "E3 ubiquitin-protein ligase Mdm2; 2.3.2.27." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1/publications", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1#A0A0G2JVC1-1", "isoform_ac": "A0A0G2JVC1-1", "locus": { "end_pos": 60720300, "start_pos": 60742415, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000086116", "id": "ENSRNOT00000086116", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000069425", "id": "ENSRNOP00000069425", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JVC1-1|A0A0G2JVC1_RAT Isoform 1 of E3 ubiquitin-protein ligase Mdm2 OS=Rattus norvegicus OX=10116 GN=Mdm2 PE=1 SV=1 CANONICAL=A0A0G2JVC1-1", "length": 483, "sequence": "MCNTNMSVSTEGAAGTSQIPASEQETLVRPKPLLLKLLKSVGAQKDIYTMKEIIFYIGQYIMTKRLYDEKQQHIVYCSNDLLGDVFGVPSFSVKEHRKIYAMIYRNLVVVSQQDSGTSPSESRCQPEGGSDLKDPVQASQEEKPSSSDVVSRPSTSSRRRAISETEENTDELPGERQRKRHRALSFDESLGLCVLREICCERSSSSEATDTPSHQDLDDGVSDHSADCLDQDSVSDQFSVEFEVESLDSEDYSLSDEGHELSDEDDEVYRVTVYQAGESDADSFEGDPEISLADYWKCTSCNEMNPPLPSHCNRCWTLRENWLPDDKGKDKVEISEKAKLESSDQAEEGLDVPDGKKVTEDDAKESSAEDSEEKVAQMLLSQESDDYSQPSTSSSIVYSSQESGKELKEDTQDKEESMESSFSLNAIEPCVICQGRPKNGCIVHGKTGHLMSCFTCAKKLKKRNKPCPVCRQPIQMIVLTYFN" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1#D3ZVH5-1", "isoform_ac": "D3ZVH5-1", "locus": { "end_pos": 60720300, "start_pos": 60742415, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000066767", "id": "ENSRNOT00000066767", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000063449", "id": "ENSRNOP00000063449", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZVH5-1|A0A0G2JVC1_RAT Computationally mapped isoform of E3 ubiquitin-protein ligase Mdm2 OS=Rattus norvegicus OX=10116 GN=Mdm2 PE=1 SV=1 CANONICAL=A0A0G2JVC1-1", "length": 458, "sequence": "MCNTNMSVSTEGAAGTSQIPASEQETLIIFYIGQYIMTKRLYDEKQQHIVYCSNDLLGDVFGVPSFSVKEHRKIYAMIYRNLVVVSQQDSGTSPSESRCQPEGGSDLKDPVQASQEEKPSSSDVVSRPSTSSRRRAISETEENTDELPGERQRKRHRALSFDESLGLCVLREICCERSSSSEATDTPSHQDLDDGVSDHSADCLDQDSVSDQFSVEFEVESLDSEDYSLSDEGHELSDEDDEVYRVTVYQAGESDADSFEGDPEISLADYWKCTSCNEMNPPLPSHCNRCWTLRENWLPDDKGKDKVEISEKAKLESSDQAEEGLDVPDGKKVTEDDAKESSAEDSEEKVAQMLLSQESDDYSQPSTSSSIVYSSQESGKELKEDTQDKEESMESSFSLNAIEPCVICQGRPKNGCIVHGKTGHLMSCFTCAKKLKKRNKPCPVCRQPIQMIVLTYFN" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-198323", "resource": "Reactome", "id": "R-RNO-198323", "name": "AKT phosphorylates targets in the cytosol" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804757", "resource": "Reactome", "id": "R-RNO-6804757", "name": "Regulation of TP53 Degradation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3232142", "resource": "Reactome", "id": "R-RNO-3232142", "name": "SUMOylation of ubiquitinylation proteins" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689880", "resource": "Reactome", "id": "R-RNO-5689880", "name": "Ub-specific processing proteases" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-399719", "resource": "Reactome", "id": "R-RNO-399719", "name": "Trafficking of AMPA receptors" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8941858", "resource": "Reactome", "id": "R-RNO-8941858", "name": "Regulation of RUNX3 expression and activity" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-69541", "resource": "Reactome", "id": "R-RNO-69541", "name": "Stabilization of p53" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2559580", "resource": "Reactome", "id": "R-RNO-2559580", "name": "Oxidative Stress Induced Senescence" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2559585", "resource": "Reactome", "id": "R-RNO-2559585", "name": "Oncogene Induced Senescence" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804756", "resource": "Reactome", "id": "R-RNO-6804756", "name": "Regulation of TP53 Activity through Phosphorylation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804760", "resource": "Reactome", "id": "R-RNO-6804760", "name": "Regulation of TP53 Activity through Methylation" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "P23804-1", "protein_name": "E3 ubiquitin-protein ligase Mdm2; 2.3.2.27; Double minute 2 protein; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; Oncoprotein Mdm2.", "sequence": { "length": 489, "sequence": "MCNTNMSVSTEGAASTSQIPASEQETLVRPKPLLLKLLKSVGAQNDTYTMKEIIFYIGQYIMTKRLYDEKQQHIVYCSNDLLGDVFGVPSFSVKEHRKIYAMIYRNLVAVSQQDSGTSLSESRRQPEGGSDLKDPLQAPPEEKPSSSDLISRLSTSSRRRSISETEENTDELPGERHRKRRRSLSFDPSLGLCELREMCSGGSSSSSSSSSESTETPSHQDLDDGVSEHSGDCLDQDSVSDQFSVEFEVESLDSEDYSLSDEGHELSDEDDEVYRVTVYQTGESDTDSFEGDPEISLADYWKCTSCNEMNPPLPSHCKRCWTLRENWLPDDKGKDKVEISEKAKLENSAQAEEGLDVPDGKKLTENDAKEPCAEEDSEEKAEQTPLSQESDDYSQPSTSSSIVYSSQESVKELKEETQDKDESVESSFSLNAIEPCVICQGRPKNGCIVHGKTGHLMSCFTCAKKLKKRNKPCPVCRQPIQMIVLTYFN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/1793", "id": "1793", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2JVC1/", "id": "A0A0G2JVC1", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q00987-1", "protein_name": "E3 ubiquitin-protein ligase Mdm2; 2.3.2.27; Double minute 2 protein; Hdm2; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; Oncoprotein Mdm2.", "sequence": { "length": 491, "sequence": "MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/1793", "id": "1793", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006241444.1", "ac": "XP_006241444.1", "name": "E3 ubiquitin-protein ligase Mdm2 isoform X2.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "ubiquitin-protein transferase activity", "id": "GO:0004842" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002039", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "p53 binding", "id": "GO:0002039" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002039", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "p53 binding", "id": "GO:0002039" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042975", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "peroxisome proliferator activated receptor binding", "id": "GO:0042975" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033612", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "receptor serine/threonine kinase binding", "id": "GO:0033612" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "zinc ion binding", "id": "GO:0008270" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "identical protein binding", "id": "GO:0042802" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "ribonucleoprotein complex binding", "id": "GO:0043021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "ubiquitin protein ligase binding", "id": "GO:0031625" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "ubiquitin protein ligase activity", "id": "GO:0061630" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047485", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "protein N-terminus binding", "id": "GO:0047485" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097110", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "scaffold protein binding", "id": "GO:0097110" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "ubiquitin binding", "id": "GO:0043130" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097718", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "disordered domain specific binding", "id": "GO:0097718" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016874", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "ligase activity", "id": "GO:0016874" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008097", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "5S rRNA binding", "id": "GO:0008097" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061663", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "NEDD8 ligase activity", "id": "GO:0061663" } ], "total": 17, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "nucleolus", "id": "GO:0005730" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "synapse", "id": "GO:0045202" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "nuclear body", "id": "GO:0016604" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "protein-containing complex", "id": "GO:0032991" } ], "total": 7, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001974", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "blood vessel remodeling", "id": "GO:0001974" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001568", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "blood vessel development", "id": "GO:0001568" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003203", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "endocardial cushion morphogenesis", "id": "GO:0003203" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003281", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "ventricular septum development", "id": "GO:0003281" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003181", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "atrioventricular valve morphogenesis", "id": "GO:0003181" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002027", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "regulation of heart rate", "id": "GO:0002027" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003283", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "atrial septum development", "id": "GO:0003283" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", "id": "A0A0G2JVC1", "database": "UniProtKB" } ], "name": "positive regulation of gene expression", "id": "GO:0010628" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "url": 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