{ "uniprot_canonical_ac": "A0A0G2JUU7-1", "sequence": { "header": "tr|A0A0G2JUU7-1|A0A0G2JUU7_RAT Isoform 1 of Gamma-tubulin complex component OS=Rattus norvegicus OX=10116 GN=Tubgcp3 PE=1 SV=1 CANONICAL=A0A0G2JUU7-1", "length": 902, "sequence": "MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQFAVRVIGSNFAPTVERDEFLVAEKIKKELIRQRREADAALFSELHRKLHSQGVLKNKWSILYLLLNLSEDPRKQASKVTSYASLFAQALPRDAHSTPYYCARPQTLPLNYQDRSTQSSGSLGSSGISSIGMCGLSGPTPVQPFLPGQSHQAPGVGDGLRQQLGPRLAWTLTGNQPSQTPTSKAFPNALSRNLTRSRREGDPGGTSEVTEAALVRDILYVFQGIDGKNIKMSSTENCYKVEAKANLSKSLRDTAVRLAELGWLHNKIRKYADQRSLDRSFGLVGQSFCAALHQELKEYYRLLSVLHSQLQLEDDQGVNVGLESSLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYMKSLVQHILSLVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMIPSFITMDQSRKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPRDAADLFTDLENAFQGKIDAAYFETSKYLLDVLNRKYSLLEHMQAMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNLTGILETAVRATNAQFDSPEILKRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHYLRVFNFLWRAKRMEYILTDIRKGHMCNAKLLRNMPEFSGVLHQCHILASEMVHFIHQMQYYITFEVLECSWDELWNRVQQAQDLDHIIAAHEAFLDTITSRCLLDSNSRVLLNQLRAVFDQIIELQNAQDTMYRAALEELQRRLQFEEKKKQRETEGQWGVTAAEEEEENKRIREFQDSIPKMCSQLRILTHFYQGVVQQFLVLLTTSSDESLQFLSFRLDFNEHYKAREPRLRVSLGSRGRRSSHT" }, "uniprot_id": "A0A0G2JUU7_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "gamma-tubulin complex component 3 isoform X1" ], "uniprotkb": [ "Gamma-tubulin complex component" ] }, "gene": { "refseq": [ "Tubgcp3" ], "uniprotkb": [ "Tubgcp3" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUU7", "id": "A0A0G2JUU7", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Gamma-tubulin complex component." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUU7#A0A0G2JUU7-1", "isoform_ac": "A0A0G2JUU7-1", "locus": { "end_pos": 82184473, "start_pos": 82244171, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000089329", "id": "ENSRNOT00000089329", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000069236", "id": "ENSRNOP00000069236", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JUU7-1|A0A0G2JUU7_RAT Isoform 1 of Gamma-tubulin complex component OS=Rattus norvegicus OX=10116 GN=Tubgcp3 PE=1 SV=1 CANONICAL=A0A0G2JUU7-1", "length": 902, "sequence": "MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQFAVRVIGSNFAPTVERDEFLVAEKIKKELIRQRREADAALFSELHRKLHSQGVLKNKWSILYLLLNLSEDPRKQASKVTSYASLFAQALPRDAHSTPYYCARPQTLPLNYQDRSTQSSGSLGSSGISSIGMCGLSGPTPVQPFLPGQSHQAPGVGDGLRQQLGPRLAWTLTGNQPSQTPTSKAFPNALSRNLTRSRREGDPGGTSEVTEAALVRDILYVFQGIDGKNIKMSSTENCYKVEAKANLSKSLRDTAVRLAELGWLHNKIRKYADQRSLDRSFGLVGQSFCAALHQELKEYYRLLSVLHSQLQLEDDQGVNVGLESSLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYMKSLVQHILSLVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMIPSFITMDQSRKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPRDAADLFTDLENAFQGKIDAAYFETSKYLLDVLNRKYSLLEHMQAMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNLTGILETAVRATNAQFDSPEILKRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHYLRVFNFLWRAKRMEYILTDIRKGHMCNAKLLRNMPEFSGVLHQCHILASEMVHFIHQMQYYITFEVLECSWDELWNRVQQAQDLDHIIAAHEAFLDTITSRCLLDSNSRVLLNQLRAVFDQIIELQNAQDTMYRAALEELQRRLQFEEKKKQRETEGQWGVTAAEEEEENKRIREFQDSIPKMCSQLRILTHFYQGVVQQFLVLLTTSSDESLQFLSFRLDFNEHYKAREPRLRVSLGSRGRRSSHT" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JUU7#D3ZMR7-1", "isoform_ac": "D3ZMR7-1", "locus": { "end_pos": 82184473, "start_pos": 82224279, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000068416", "id": "ENSRNOT00000068416", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000060338", "id": "ENSRNOP00000060338", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZMR7-1|A0A0G2JUU7_RAT Computationally mapped isoform of Gamma-tubulin complex component OS=Rattus norvegicus OX=10116 GN=Tubgcp3 PE=1 SV=1 CANONICAL=A0A0G2JUU7-1", "length": 606, "sequence": "MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQFAVRVIGSNFAPTVERDEFLVAEKIKKELIRQRREADAALFSELHRKLHSQGVLKNKWSILYLLLNLSEDPRKQASKVTSYASLFAQALPRDAHSTPYYCARPQTLPLNYQDRSTQSSGSLGSSGISSIGMCGLSGPTPVQPFLPGQSHQAPGVGDGLRQQLGPRLAWTLTGNQPSQTPTSKAFPNALSRNLTRSRREGDPGGTSEVTEAALVRDILYVFQGIDGKNIKMSSTENCYKVEAKANLSKSLRDTAVRLAELGWLHNKIRKYADQRSLDRSFGLVGQSFCAALHQELKEYYRLLSVLHSQLQLEDDQGVNVGLESSLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYMKSLVQHILSLVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMIPSFITMDQSRKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPRDAADLFTDLENAFQGKIDAAYFETSKYLLDVLNRKYSLLEHMQAMRRYLLLGQGDFIRHLMDLLKSLLVTLGGMSSAWITTSTDQLPLCSHESA" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-380270", "resource": "Reactome", "id": "R-RNO-380270", "name": "Recruitment of mitotic centrosome proteins and complexes" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-380320", "resource": "Reactome", "id": "R-RNO-380320", "name": "Recruitment of NuMA to mitotic centrosomes" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUU7#function", "annotation": "Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUU7#function", "id": "A0A0G2JUU7", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P58854-1", "protein_name": "Gamma-tubulin complex component 3; GCP-3.", "sequence": { "length": 905, "sequence": "MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQFAVRVIGSNFAPTVERDEFLVAEKIKKELIRQRREADAALFSELHRKLHSQGVLKNKWSILYLLLNLSEDPRKQASKVTSYASLFAQALPRDAHSTPYYYARPQTLPLNYQDRSTQAQSSGSLGSSGISSIGMCGLSGPTPVQPFLPGQSHQAPGVGDGLRQQLGPRLAWTLTGNQPSSQTPTSKGFPNALSRNLTRSRREGDPGGTLEVTEAALVRDILYVFQGIDGKNIKMSSTENCYKVEAKANLNKSLRDTAVRLAELGWLHNKIRKYADQRSLDRSFGLVGQSFCAALHQELKEYYRLLSVLHSQLQLEDDQGVNLGLESSLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYMKSLVQHILSLVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMIPSFITMDQSRKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPRDAADLFTDLENAFQGKIDAAYFETSKYLLDVLNKKYSLLEHMQAMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNLTGILETAVRATNAQFDSPEILKRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHYLRVFNFLWRAKRMEYILTDIRKGHMCNAKLLRNMPEFSGVLHQCHILASEMVHFIHQMQYYITFEVLECSWDELWNRVQQAQDLDHIIAAHEAFLNTITSRCLLDSNSRVLLNQLRAVFDQIIELQNAQDVMYRAALEELQRRLQFEEKKKQREIEGQWGVTAAEEEEENKRIREFQDSIPKMCSQLRILTHFYQGVVQQFLVLLTTSSDESLQFLSFRLDFNEHYKAREPRLRVSLGSRGRRSSHT" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2JUU7/", "id": "A0A0G2JUU7", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q96CW5-1", "protein_name": "Gamma-tubulin complex component 3; GCP-3; hGCP3; Gamma-ring complex protein 104 kDa; h104p; hGrip104; Spindle pole body protein Spc98 homolog; hSpc98.", "sequence": { "length": 907, "sequence": "MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQYAVRVIGSNFAPTVERDEFLVAEKIKKELIRQRREADAALFSELHRKLHSQGVLKNKWSILYLLLSLSEDPRRQPSKVSSYATLFAQALPRDAHSTPYYYARPQTLPLSYQDRSAQSAQSSGSVGSSGISSIGLCALSGPAPAPQSLLPGQSNQAPGVGDCLRQQLGSRLAWTLTANQPSSQATTSKGVPSAVSRNMTRSRREGDTGGTMEITEAALVRDILYVFQGIDGKNIKMNNTENCYKVEGKANLSRSLRDTAVRLSELGWLHNKIRRYTDQRSLDRSFGLVGQSFCAALHQELREYYRLLSVLHSQLQLEDDQGVNLGLESSLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYMRSLVQHILSLVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMIPSFMTMDQSRKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPQDAADLFTDLENAFQGKIDAAYFETSKYLLDVLNKKYSLLDHMQAMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNLTGILETAVRATNAQFDSPEILRRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHYLRVFNFLWRAKRMEYILTDIRKGHMCNAKLLRNMPEFSGVLHQCHILASEMVHFIHQMQYYITFEVLECSWDELWNKVQQAQDLDHIIAAHEVFLDTIISRCLLDSDSRALLNQLRAVFDQIIELQNAQDAIYRAALEELQRRLQFEEKKKQREIEGQWGVTAAEEEEENKRIGEFKESIPKMCSQLRILTHFYQGIVQQFLVLLTTSSDESLRFLSFRLDFNEHYKAREPRLRVSLGTRGRRSSHT" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2JUU7/", "id": "A0A0G2JUU7", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006253502.1", "ac": "XP_006253502.1", "name": "gamma-tubulin complex component 3 isoform X1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043015", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUU7", "id": "A0A0G2JUU7", "database": "UniProtKB" } ], "name": "gamma-tubulin binding", "id": "GO:0043015" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008275", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUU7", "id": "A0A0G2JUU7", "database": "UniProtKB" } ], "name": "gamma-tubulin small complex", "id": "GO:0008275" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUU7", "id": "A0A0G2JUU7", "database": "UniProtKB" } ], "name": "centrosome", "id": "GO:0005813" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000930", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUU7", "id": "A0A0G2JUU7", "database": "UniProtKB" } ], "name": "gamma-tubulin complex", "id": "GO:0000930" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000923", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUU7", "id": "A0A0G2JUU7", "database": "UniProtKB" } ], "name": "equatorial microtubule organizing center", "id": "GO:0000923" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUU7", "id": "A0A0G2JUU7", "database": "UniProtKB" } ], "name": "centriole", "id": "GO:0005814" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005827", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUU7", "id": "A0A0G2JUU7", "database": "UniProtKB" } ], "name": "polar microtubule", "id": "GO:0005827" } ], "total": 6, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUU7", "id": "A0A0G2JUU7", "database": "UniProtKB" } ], "name": "mitotic cell cycle", "id": "GO:0000278" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051225", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUU7", "id": "A0A0G2JUU7", "database": "UniProtKB" } ], "name": "spindle assembly", "id": "GO:0051225" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051321", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUU7", "id": "A0A0G2JUU7", "database": "UniProtKB" } ], "name": "meiotic cell cycle", "id": "GO:0051321" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031122", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUU7", "id": "A0A0G2JUU7", "database": "UniProtKB" } ], "name": "cytoplasmic microtubule organization", "id": "GO:0031122" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051415", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUU7", "id": "A0A0G2JUU7", "database": "UniProtKB" } ], "name": "microtubule nucleation by interphase microtubule organizing center", "id": "GO:0051415" } ], "total": 5, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 101, "annotation": "n_glycosylation_sequon", "start_pos": 99 }, { "end_pos": 226, "annotation": "n_glycosylation_sequon", "start_pos": 224 }, { "end_pos": 279, "annotation": "n_glycosylation_sequon", "start_pos": 277 }, { "end_pos": 593, "annotation": "n_glycosylation_sequon", "start_pos": 591 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006253502.1", "id": "XP_006253502.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-380270", "id": "R-RNO-380270", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-380320", "id": "R-RNO-380320", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000017085", "id": "ENSRNOG00000017085", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/EYKVDAP/", "id": "EYKVDAP", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007259", "id": "IPR007259", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR040457", "id": "IPR040457", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041470", "id": "IPR041470", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF04130", "id": "PF04130", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF17681", "id": "PF17681", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19302", "id": "PTHR19302", "database": "PANTHER" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/306599", "id": "306599", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305726", "id": "1305726", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2JUU7", "disease": [], "mass": { "monoisotopic_mass": 103089.0, "chemical_mass": 103089.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUU7", "name": "Tubgcp3.", "locus": { "end_pos": 82245041, "start_pos": 82184387, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000017085", "id": "ENSRNOG00000017085", "database": "Ensembl Gene" } ] } } ] }