{ "uniprot_canonical_ac": "A0A0G2JTZ2-1", "sequence": { "header": "tr|A0A0G2JTZ2-1|A0A0G2JTZ2_RAT Isoform 1 of SRY-box transcription factor 6 OS=Rattus norvegicus OX=10116 GN=Sox6 PE=4 SV=1 CANONICAL=A0A0G2JTZ2-1", "length": 854, "sequence": "MPSSSEVLADVARESRIEEWRNSYFVRMSSKQATSPFACTVDGEETMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGISDRLGRNLDPYEHGGGHSYNHKQIEQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQSLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNSMGLSNCRNEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN" }, "uniprot_id": "A0A0G2JTZ2_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "transcription factor SOX-6 isoform X1" ], "uniprotkb": [ "SRY-box transcription factor 6", "SRY-box containing gene 6, isoform CRA_b" ] }, "gene": { "refseq": [ "Sox6" ], "uniprotkb": [ "Sox6", "rCG_39741" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "SRY-box transcription factor 6; SRY-box containing gene 6, isoform CRA_b." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2#A0A0G2JTZ2-1", "isoform_ac": "A0A0G2JTZ2-1", "locus": { "end_pos": 185863242, "start_pos": 186182628, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000079072", "id": "ENSRNOT00000079072", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068898", "id": "ENSRNOP00000068898", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JTZ2-1|A0A0G2JTZ2_RAT Isoform 1 of SRY-box transcription factor 6 OS=Rattus norvegicus OX=10116 GN=Sox6 PE=4 SV=1 CANONICAL=A0A0G2JTZ2-1", "length": 854, "sequence": "MPSSSEVLADVARESRIEEWRNSYFVRMSSKQATSPFACTVDGEETMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGISDRLGRNLDPYEHGGGHSYNHKQIEQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQSLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNSMGLSNCRNEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2#Q4V8G3-1", "isoform_ac": "Q4V8G3-1", "locus": { "end_pos": 185878827, "start_pos": 186182628, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000048020", "id": "ENSRNOT00000048020", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000044088", "id": "ENSRNOP00000044088", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q4V8G3-1|A0A0G2JTZ2_RAT Computationally mapped isoform of SRY-box transcription factor 6 OS=Rattus norvegicus OX=10116 GN=Sox6 PE=4 SV=1 CANONICAL=A0A0G2JTZ2-1", "length": 787, "sequence": "MSSKQATSPFACTVDGEETMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQSLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNSMGLSNCRNEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3769402", "resource": "Reactome", "id": "R-RNO-3769402", "name": "Deactivation of the beta-catenin transactivating complex" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "P35712-1", "protein_name": "Transcription factor SOX-6.", "sequence": { "length": 828, "sequence": "MSSKQATSPFACAADGEDAMTQDLTSREKEEGSDQHVASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSRDREIMTSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINQRLKGLSDRFGRNLDTFEHGGGHSYNHKQIEQLYAAQLASMQVSPGAKMPSTPQPPNTAGTVSPTGIKNEKRGTSPVTQVKDEAAAQPLNLSSRPKTAEPVKSPTSPTQNLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQQPHGVDGKLSSINNMGLNSCRNEKERTRFENLGPQLTGKSNEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKTDGGSLAGNEMINGEDEMEMYDDYEDDPKSDYSSENEAPEAVSAN" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2JTZ2/", "id": "A0A0G2JTZ2", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/22631", "id": "22631", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "P40645-1", "protein_name": "Transcription factor SOX-6; SOX-LZ.", "sequence": { "length": 827, "sequence": "MSSKQATSPFACTADGEEAMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGISDRFGRNLDPSEHGGGHSYNHRQIEQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQNLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNNMGLSNCRTEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQMPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/22631", "id": "22631", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006230149.1", "ac": "XP_006230149.1", "name": "transcription factor SOX-6 isoform X1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "protein heterodimerization activity", "id": "GO:0046982" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "RNA polymerase II proximal promoter sequence-specific DNA binding", "id": "GO:0000978" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048708", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "astrocyte differentiation", "id": "GO:0048708" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "negative regulation of transcription, DNA-templated", "id": "GO:0045892" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032332", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "positive regulation of chondrocyte differentiation", "id": "GO:0032332" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045165", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "cell fate commitment", "id": "GO:0045165" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "in utero embryonic development", "id": "GO:0001701" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000902", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "cell morphogenesis", "id": "GO:0000902" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009791", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "post-embryonic development", "id": "GO:0009791" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071560", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "cellular response to transforming growth factor beta stimulus", "id": "GO:0071560" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055007", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "cardiac muscle cell differentiation", "id": "GO:0055007" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051216", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "cartilage development", "id": "GO:0051216" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048821", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "erythrocyte development", "id": "GO:0048821" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021778", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "oligodendrocyte cell fate specification", "id": "GO:0021778" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000741", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "positive regulation of mesenchymal stem cell differentiation", "id": "GO:2000741" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000726", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "negative regulation of cardiac muscle cell differentiation", "id": "GO:2000726" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016458", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "gene silencing", "id": "GO:0016458" } ], "total": 16, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 123, "annotation": "n_glycosylation_sequon", "start_pos": 121 }, { "end_pos": 198, "annotation": "n_glycosylation_sequon", "start_pos": 196 }, { "end_pos": 455, "annotation": "n_glycosylation_sequon", "start_pos": 453 }, { "end_pos": 489, "annotation": "n_glycosylation_sequon", "start_pos": 487 }, { "end_pos": 611, "annotation": "n_glycosylation_sequon", "start_pos": 609 }, { "end_pos": 678, "annotation": "n_glycosylation_sequon", "start_pos": 676 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006230149.1", "id": "XP_006230149.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3769402", "id": "R-RNO-3769402", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020514", "id": "ENSRNOG00000020514", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/DEIEMYE/", "id": "DEIEMYE", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027153", "id": "IPR027153", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036910", "id": "IPR036910", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009071", "id": "IPR009071", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00505", "id": "PF00505", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45789:SF1", "id": "PTHR45789:SF1", "database": "PANTHER" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/293165", "id": "293165", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309000", "id": "1309000", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2JTZ2", "disease": [], "mass": { "monoisotopic_mass": 95013.0, "chemical_mass": 95013.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "name": "Sox6; rCG_39741.", "locus": { "end_pos": 186182829, "start_pos": 185673177, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000020514", "id": "ENSRNOG00000020514", "database": "Ensembl Gene" } ] } } ] }