{ "uniprot_canonical_ac": "A0A0G2JTY3-1", "sequence": { "header": "tr|A0A0G2JTY3-1|A0A0G2JTY3_RAT Isoform 1 of Solute carrier family 37 member 4 OS=Rattus norvegicus OX=10116 GN=Slc37a4 PE=1 SV=1 CANONICAL=A0A0G2JTY3-1", "length": 450, "sequence": "MAAQGYGYYRTVIFTAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVTAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGSLCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAMAKAGLSVYGNPRHSLLLLMMAGMAASMFLFRVTVTSDSPKEAFWTPALHPLAELTGFTEHEIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICIASTVVFFLLRNIRTKMGRVSKKAE" }, "uniprot_id": "A0A0G2JTY3_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "glucose-6-phosphate exchanger SLC37A4 isoform X1" ], "uniprotkb": [ "Solute carrier family 37 member 4" ] }, "gene": { "refseq": [ "Slc37a4", "G6pt1" ], "uniprotkb": [ "Slc37a4", "G6pt1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Solute carrier family 37 member 4." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3#A0A0G2JTY3-1", "isoform_ac": "A0A0G2JTY3-1", "locus": { "end_pos": 48718525, "start_pos": 48722512, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000089763", "id": "ENSRNOT00000089763", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068889", "id": "ENSRNOP00000068889", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JTY3-1|A0A0G2JTY3_RAT Isoform 1 of Solute carrier family 37 member 4 OS=Rattus norvegicus OX=10116 GN=Slc37a4 PE=1 SV=1 CANONICAL=A0A0G2JTY3-1", "length": 450, "sequence": "MAAQGYGYYRTVIFTAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVTAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGSLCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAMAKAGLSVYGNPRHSLLLLMMAGMAASMFLFRVTVTSDSPKEAFWTPALHPLAELTGFTEHEIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICIASTVVFFLLRNIRTKMGRVSKKAE" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3#Q6IRK4-1", "isoform_ac": "Q6IRK4-1", "locus": { "end_pos": 48718525, "start_pos": 48722512, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000015810", "id": "ENSRNOT00000015810", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000015810", "id": "ENSRNOP00000015810", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q6IRK4-1|A0A0G2JTY3_RAT Computationally mapped isoform of Solute carrier family 37 member 4 OS=Rattus norvegicus OX=10116 GN=Slc37a4 PE=1 SV=1 CANONICAL=A0A0G2JTY3-1", "length": 429, "sequence": "MAAQGYGYYRTVIFTAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVTAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGSLCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAMAKAGLSVYGNPRHSLLLLMMAGMAASMFLFRVTVTSDSPKIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICIASTVVFFLLRNIRTKMGRVSKKAE" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-70263", "resource": "Reactome", "id": "R-RNO-70263", "name": "Gluconeogenesis" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "A0A1L1SUI3-1", "protein_name": "Solute carrier family 37 (glucose-6-phosphate transporter), member 4.", "sequence": { "length": 450, "sequence": "MAAQGYGYYRTVIFAAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAMAKAGLSLYGNPRHGLLLLMMAGMAASMFLFRVTVTSDSPKDAFWTPALHPLAELTGFTEHEIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLRNIRTKMGRVSKKGE" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/37482", "id": "37482", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "O43826-1", "protein_name": "Glucose-6-phosphate exchanger SLC37A4; Transformation-related gene 19 protein; TRG-19; Glucose-6-phosphate translocase; Glucose-5-phosphate transporter; Solute carrier family 37 member 4.", "sequence": { "length": 429, "sequence": "MAAQGYGYYRTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGLRNLDPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSNYGNPRHGLLLFMMAGMTVSMYLFRVTVTSDSPKLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLLRNIRTKMGRVSKKAE" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/37482", "id": "37482", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008764374.1", "ac": "XP_008764374.1", "name": "glucose-6-phosphate exchanger SLC37A4 isoform X1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015152", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "glucose-6-phosphate transmembrane transporter activity", "id": "GO:0015152" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "intracellular membrane-bounded organelle", "id": "GO:0043231" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005887", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "integral component of plasma membrane", "id": "GO:0005887" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007584", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "response to nutrient", "id": "GO:0007584" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005977", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "glycogen metabolic process", "id": "GO:0005977" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014070", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "response to organic cyclic compound", "id": "GO:0014070" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009749", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "response to glucose", "id": "GO:0009749" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015760", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "glucose-6-phosphate transport", "id": "GO:0015760" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002318", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "myeloid progenitor cell differentiation", "id": "GO:0002318" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006641", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "triglyceride metabolic process", "id": "GO:0006641" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006874", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "cellular calcium ion homeostasis", "id": "GO:0006874" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043085", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "positive regulation of catalytic activity", "id": "GO:0043085" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "glucose homeostasis", "id": "GO:0042593" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042632", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "cholesterol homeostasis", "id": "GO:0042632" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008202", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "steroid metabolic process", "id": "GO:0008202" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001780", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "neutrophil homeostasis", "id": "GO:0001780" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001816", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "cytokine production", "id": "GO:0001816" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030593", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "neutrophil chemotaxis", "id": "GO:0030593" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045730", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "respiratory burst", "id": "GO:0045730" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006089", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "lactate metabolic process", "id": "GO:0006089" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032682", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "negative regulation of chemokine production", "id": "GO:0032682" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035166", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "id": "A0A0G2JTY3", "database": "UniProtKB" } ], "name": "post-embryonic hemopoiesis", "id": "GO:0035166" } ], "total": 19, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 377, "annotation": "n_glycosylation_sequon", "start_pos": 375 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008764374.1", "id": "XP_008764374.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-70263", "id": "R-RNO-70263", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000011361", "id": "ENSRNOG00000011361", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/NAWFQGW/", "id": "NAWFQGW", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "id": "IPR036259", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000849", "id": "IPR000849", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR021159", "id": "IPR021159", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011701", "id": "IPR011701", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "id": "IPR020846", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF07690", "id": "PF07690", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/29573", "id": "29573", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=62066", "id": "62066", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2JTY3", "disease": [], "mass": { "monoisotopic_mass": 48603.0, "chemical_mass": 48603.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY3", "name": "Slc37a4; G6pt1.", "locus": { "end_pos": 48723024, "start_pos": 48716939, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000011361", "id": "ENSRNOG00000011361", "database": "Ensembl Gene" } ] } } ] }