{ "uniprot_canonical_ac": "A0A0G2JTM7-1", "sequence": { "header": "tr|A0A0G2JTM7-1|A0A0G2JTM7_RAT Isoform 1 of Bromodomain-containing 7 OS=Rattus norvegicus OX=10116 GN=Brd7 PE=1 SV=1 CANONICAL=A0A0G2JTM7-1", "length": 652, "sequence": "MGKKHKKHKSDRHFYEEYVEKPLKLVLKVGGSEVTELSTGSSGHDSSLFEDRSDHDKHKDRKRKKRKKGEKQAPGEEKGRKRRRVKEDKKKRDRDRVENEADKDLQCHVPIRLDLPPEKPLTSSLAKQEEVEQTPLQEALNQLMRQLQRKDPSAFFSFPVTDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYYKAAKKLLHSGMKILSQERIQSLKQSIDFMADLQKTRKQKDRADACQGGEDSGCWQREREDSGDAETQAFKSPTKDNKKKDKDVLEDKWRSSNSEREHEQIERVVQESGGKLTRRLANCQCEFERRKPDGTTTLGLLHPVDPIVGEPGYCPVRLGMTTGRLQSGVNTLQGFKEDKRNRVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPNNFSISEFLATCQDYPYVMADSLLDVLTKGGHSRSLQDLDMPSPEDEGQTRALDVAKEAEQVAHIEPAGRLESSGQDRLTALQAVTNFGAPAEVFDSEEAEVFQRKLDETTRLLRELQEAQNERLSTRPPPNMICLLGPSYREMYLAEQVTNNLKELTQQVTPGDVVSIHGVRKAMGISVPSPIMGHSLVDLTEECEDPKETSTAESGPAAS" }, "uniprot_id": "A0A0G2JTM7_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "bromodomain-containing protein 7 isoform X1" ], "uniprotkb": [ "Bromodomain-containing 7" ] }, "gene": { "refseq": [ "Brd7" ], "uniprotkb": [ "Brd7" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM7", "id": "A0A0G2JTM7", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Bromodomain-containing 7." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM7/publications", "id": "A0A0G2JTM7", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM7#A0A0G2JTM7-1", "isoform_ac": "A0A0G2JTM7-1", "locus": { "end_pos": 19673051, "start_pos": 19701304, "chromosome": "19", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000086560", "id": "ENSRNOT00000086560", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068771", "id": "ENSRNOP00000068771", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JTM7-1|A0A0G2JTM7_RAT Isoform 1 of Bromodomain-containing 7 OS=Rattus norvegicus OX=10116 GN=Brd7 PE=1 SV=1 CANONICAL=A0A0G2JTM7-1", "length": 652, "sequence": "MGKKHKKHKSDRHFYEEYVEKPLKLVLKVGGSEVTELSTGSSGHDSSLFEDRSDHDKHKDRKRKKRKKGEKQAPGEEKGRKRRRVKEDKKKRDRDRVENEADKDLQCHVPIRLDLPPEKPLTSSLAKQEEVEQTPLQEALNQLMRQLQRKDPSAFFSFPVTDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYYKAAKKLLHSGMKILSQERIQSLKQSIDFMADLQKTRKQKDRADACQGGEDSGCWQREREDSGDAETQAFKSPTKDNKKKDKDVLEDKWRSSNSEREHEQIERVVQESGGKLTRRLANCQCEFERRKPDGTTTLGLLHPVDPIVGEPGYCPVRLGMTTGRLQSGVNTLQGFKEDKRNRVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPNNFSISEFLATCQDYPYVMADSLLDVLTKGGHSRSLQDLDMPSPEDEGQTRALDVAKEAEQVAHIEPAGRLESSGQDRLTALQAVTNFGAPAEVFDSEEAEVFQRKLDETTRLLRELQEAQNERLSTRPPPNMICLLGPSYREMYLAEQVTNNLKELTQQVTPGDVVSIHGVRKAMGISVPSPIMGHSLVDLTEECEDPKETSTAESGPAAS" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM7#D3ZXX7-1", "isoform_ac": "D3ZXX7-1", "locus": { "end_pos": 19688702, "start_pos": 19701304, "chromosome": "19", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000064275", "id": "ENSRNOT00000064275", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000063186", "id": "ENSRNOP00000063186", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZXX7-1|A0A0G2JTM7_RAT Computationally mapped isoform of Bromodomain-containing 7 OS=Rattus norvegicus OX=10116 GN=Brd7 PE=1 SV=1 CANONICAL=A0A0G2JTM7-1", "length": 406, "sequence": "MADLQKTRKQKDRADACQGGEDSGCWQREREDSGDAETQAFKSPTKDNKKKDKDVLEDKWRSSNSEREHEQIERVVQESGGKLTRRLANCQCEFERRKPDGTTTLGLLHPVDPIVGEPGYCPVRLGMTTGRLQSGVNTLQGFKEDKRNRVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPNNFSISEFLATCQDYPYVMADSLLDVLTKGGHSRSLQDLDMPSPEDEGQTRALDVAKEAEQVAHIEPAGRLESSGQDRLTALQAVTNFGAPAEVFDSEEAEVFQRKLDETTRLLRELQEAQNERLSTRPPPNMICLLGPSYREMYLAEQVTNNLKELTQQVTPGDVVSIHGVRKAMGISVPSPIMGHSLVDLTEECEDPKETSTAESGPAAS" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804758", "resource": "Reactome", "id": "R-RNO-6804758", "name": "Regulation of TP53 Activity through Acetylation" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "O88665-1", "protein_name": "Bromodomain-containing protein 7; 75 kDa bromodomain protein.", "sequence": { "length": 651, "sequence": "MGKKHKKHKSDRHFYEEYVEKPLKLVLKVGGSEVTELSTGSSGHDSSLFEDRSDHDKHKDRKRKKRKKGEKQAPGEEKGRKRRRVKEDKKKRDRDRAENEVDRDLQCHVPIRLDLPPEKPLTSSLAKQEEVEQTPLQEALNQLMRQLQRKDPSAFFSFPVTDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYYKAAKKLLHSGMKILSQERIQSLKQSIDFMSDLQKTRKQKERTDACQSGEDSGCWQREREDSGDAETQAFRSPAKDNKRKDKDVLEDKWRSSNSEREHEQIERVVQESGGKLTRRLANSQCEFERRKPDGTTTLGLLHPVDPIVGEPGYCPVRLGMTTGRLQSGVNTLQGFKEDKRNRVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPNNFSISEFLATCQDYPYVMADSLLDVLTKGGHSRSLQDLDMSSPEDEGQTRALDTAKEAEITQIEPTGRLESSSQDRLTALQAVTTFGAPAEVFDSEEAEVFQRKLDETTRLLRELQEAQNERLSTRPPPNMICLLGPSYREMYLAEQVTNNLKELTQQVTPGDVVSIHGVRKAMGISVPSPIVGNSFVDLTGECEEPKETSTAECGPDAS" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2JTM7/", "id": "A0A0G2JTM7", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006255329.1", "ac": "XP_006255329.1", "name": "bromodomain-containing protein 7 isoform X1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM7", "id": "A0A0G2JTM7", "database": "UniProtKB" } ], "name": "transcription coactivator activity", "id": "GO:0003713" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM7", "id": "A0A0G2JTM7", "database": "UniProtKB" } ], "name": "transcription corepressor activity", "id": "GO:0003714" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008134", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM7", "id": "A0A0G2JTM7", "database": "UniProtKB" } ], "name": "transcription factor binding", "id": "GO:0008134" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044212", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM7", "id": "A0A0G2JTM7", "database": "UniProtKB" } ], "name": "transcription regulatory region DNA binding", "id": "GO:0044212" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070577", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM7", "id": "A0A0G2JTM7", "database": "UniProtKB" } ], "name": "lysine-acetylated histone binding", "id": "GO:0070577" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002039", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM7", "id": "A0A0G2JTM7", "database": "UniProtKB" } ], "name": "p53 binding", "id": "GO:0002039" } ], "total": 6, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM7", "id": "A0A0G2JTM7", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM7", "id": "A0A0G2JTM7", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM7", "id": "A0A0G2JTM7", "database": "UniProtKB" } ], "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM7", "id": "A0A0G2JTM7", "database": "UniProtKB" } ], "name": "negative regulation of cell population proliferation", "id": "GO:0008285" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM7", "id": "A0A0G2JTM7", "database": "UniProtKB" } ], "name": "negative regulation of transcription, DNA-templated", "id": "GO:0045892" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM7", "id": "A0A0G2JTM7", "database": "UniProtKB" } ], "name": "positive regulation of transcription, DNA-templated", "id": "GO:0045893" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000134", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM7", "id": "A0A0G2JTM7", "database": "UniProtKB" } ], "name": "negative regulation of G1/S transition of mitotic cell cycle", "id": "GO:2000134" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035066", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM7", "id": "A0A0G2JTM7", "database": "UniProtKB" } ], "name": "positive regulation of histone acetylation", "id": "GO:0035066" } ], "total": 6, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 422, "annotation": "n_glycosylation_sequon", "start_pos": 420 }, { "end_pos": 444, "annotation": "n_glycosylation_sequon", "start_pos": 442 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006255329.1", "id": "XP_006255329.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804758", "id": "R-RNO-6804758", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000014419", "id": "ENSRNOG00000014419", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/PADDNSI/", "id": "PADDNSI", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001487", "id": "IPR001487", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036427", "id": "IPR036427", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR021900", "id": "IPR021900", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00439", "id": "PF00439", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF12024", "id": "PF12024", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/361374", "id": "361374", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309891", "id": "1309891", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2JTM7", "disease": [], "mass": { "monoisotopic_mass": 73945.0, "chemical_mass": 73945.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM7", "name": "Brd7.", "locus": { "end_pos": 19701484, "start_pos": 19672856, "chromosome": "19", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000014419", "id": "ENSRNOG00000014419", "database": "Ensembl Gene" } ] } } ] }