{ "uniprot_canonical_ac": "A0A0G2JTM3-1", "sequence": { "header": "tr|A0A0G2JTM3-1|A0A0G2JTM3_RAT Isoform 1 of Ets variant 1 OS=Rattus norvegicus OX=10116 GN=Etv1 PE=3 SV=1 CANONICAL=A0A0G2JTM3-1", "length": 477, "sequence": "MDGFYDQQVPYVVTNSQRGRNCTEKPTNVRKRKFINRDLAHDSEELFQDLSQLQETWLAEAQVPDNDEQFVPDYQAESLAFHGLPLKIKKEPHSPCSELGSACSQEQPFKFSYGEKCLYNVSAYDQKPQVGMRPSNPPTPSSTPVSPLHHASPNTAHTPKPDRAFPAHLPPSQSIPDSTYPMDHRFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHTTMVGGAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQESFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMTYMPEGGCCNPHPYNEGYVY" }, "uniprot_id": "A0A0G2JTM3_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "ETS translocation variant 1 isoform a", "ets variant gene 1; ETS translocation variant 1; ets variant 1" ], "uniprotkb": [ "Ets variant 1" ] }, "gene": { "refseq": [ "Etv1" ], "uniprotkb": [ "Etv1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM3", "id": "A0A0G2JTM3", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Ets variant 1." }, "publication": [ { "title": "Putative regulation of expression of members of the Ets variant 4 transcription factor family and their downstream targets in the rat epididymis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16394217", "journal": "Biology of reproduction", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156628.1", "id": "NP_001156628.1", "database": "RefSeq" } ], "authors": "Yang L, Fox SA, Kirby JL, Troan BV, Hinton BT", "date": "2006", "pmid": "16394217" }, { "title": "Ets transcription factors ER81 and Elk1 regulate the transcription of the human presenilin 1 gene promoter.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12750007", "journal": "Brain research. Molecular brain research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156628.1", "id": "NP_001156628.1", "database": "RefSeq" } ], "authors": "Pastorcic M, Das HK", "date": "2003", "pmid": "12750007" }, { "title": "ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/10850491", "journal": "Cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156628.1", "id": "NP_001156628.1", "database": "RefSeq" } ], "authors": "Arber S, Ladle DR, Lin JH, Frank E, Jessell TM", "date": "2000", "pmid": "10850491" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM3#A0A0G2JTM3-1", "isoform_ac": "A0A0G2JTM3-1", "locus": { "end_pos": 58468818, "start_pos": 58553500, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000091263", "id": "ENSRNOT00000091263", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068767", "id": "ENSRNOP00000068767", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JTM3-1|A0A0G2JTM3_RAT Isoform 1 of Ets variant 1 OS=Rattus norvegicus OX=10116 GN=Etv1 PE=3 SV=1 CANONICAL=A0A0G2JTM3-1", "length": 477, "sequence": "MDGFYDQQVPYVVTNSQRGRNCTEKPTNVRKRKFINRDLAHDSEELFQDLSQLQETWLAEAQVPDNDEQFVPDYQAESLAFHGLPLKIKKEPHSPCSELGSACSQEQPFKFSYGEKCLYNVSAYDQKPQVGMRPSNPPTPSSTPVSPLHHASPNTAHTPKPDRAFPAHLPPSQSIPDSTYPMDHRFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHTTMVGGAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQESFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMTYMPEGGCCNPHPYNEGYVY" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM3#B5DEZ2-1", "isoform_ac": "B5DEZ2-1", "locus": { "end_pos": 58468818, "start_pos": 58553500, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000065396", "id": "ENSRNOT00000065396", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000059718", "id": "ENSRNOP00000059718", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|B5DEZ2-1|A0A0G2JTM3_RAT Computationally mapped isoform of Ets variant 1 OS=Rattus norvegicus OX=10116 GN=Etv1 PE=3 SV=1 CANONICAL=A0A0G2JTM3-1", "length": 454, "sequence": "MDGFYDQQVPYVVTNSQRGRNCTEKPTNVRKRKFINRDLAHDSEELFQDLSQLQETWLAEAQVPDNDEQFVPDYQAESLAFHGLPLKIKKEPHSPCSELGSACSQEQPFKFSYGEKCLYNVSAYDQKPQVGMRPSNPPTPSSTPVSPLHHASPNTAHTPKPDRAFPAHLPPSQSIPDSTYPMDHRFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHTTMVGGAASQSFPPPLMIKQEPRDFAYDSGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMTYMPEGGCCNPHPYNEGYVY" } } ], "pathway": [], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156628.1", "annotation": "The data suggest that ETV4 family members regulate their own expression, and that they regulate transcription of a subset of genes that are dependent upon testicular luminal fluid factors.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156628.1", "id": "NP_001156628.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P41164-1", "protein_name": "ETS translocation variant 1; Ets-related protein 81.", "sequence": { "length": 477, "sequence": "MDGFYDQQVPYVVTNSQRGRNCTEKPTNVRKRKFINRDLAHDSEELFQDLSQLQETWLAEAQVPDNDEQFVPDYQAESLAFHGLPLKIKKEPHSPCSELGSACSQEQPFKFSYGEKCLYNVSAYDQKPQVGMRPSNPPTPSSTPVSPLHHASPNTAHTPKPDRAFPAHLPPSQSIPDSTYPMDHRFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHTTMVGGAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMTYMPEGGCCNPHPYNEGYVY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/3636", "id": "3636", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "P50549-1", "protein_name": "ETS translocation variant 1; Ets-related protein 81.", "sequence": { "length": 477, "sequence": "MDGFYDQQVPYMVTNSQRGRNCNEKPTNVRKRKFINRDLAHDSEELFQDLSQLQETWLAEAQVPDNDEQFVPDYQAESLAFHGLPLKIKKEPHSPCSEISSACSQEQPFKFSYGEKCLYNVSAYDQKPQVGMRPSNPPTPSSTPVSPLHHASPNSTHTPKPDRAFPAHLPPSQSIPDSSYPMDHRFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYVY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/3636", "id": "3636", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156628.1", "ac": "NP_001156628.1", "name": "ETS translocation variant 1 isoform a; ets variant gene 1; ETS translocation variant 1; ets variant 1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM3", "id": "A0A0G2JTM3", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM3", "id": "A0A0G2JTM3", "database": "UniProtKB" } ], "name": "RNA polymerase II proximal promoter sequence-specific DNA binding", "id": "GO:0000978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM3", "id": "A0A0G2JTM3", "database": "UniProtKB" } ], "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM3", "id": "A0A0G2JTM3", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM3", "id": "A0A0G2JTM3", "database": "UniProtKB" } ], "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM3", "id": "A0A0G2JTM3", "database": "UniProtKB" } ], "name": "cell differentiation", "id": "GO:0030154" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007638", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM3", "id": "A0A0G2JTM3", "database": "UniProtKB" } ], "name": "mechanosensory behavior", "id": "GO:0007638" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007517", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM3", "id": "A0A0G2JTM3", "database": "UniProtKB" } ], "name": "muscle organ development", "id": "GO:0007517" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM3", "id": "A0A0G2JTM3", "database": "UniProtKB" } ], "name": "transcription by RNA polymerase II", "id": "GO:0006366" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM3", "id": "A0A0G2JTM3", "database": "UniProtKB" } ], "name": "axon guidance", "id": "GO:0007411" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048935", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM3", "id": "A0A0G2JTM3", "database": "UniProtKB" } ], "name": "peripheral nervous system neuron development", "id": "GO:0048935" } ], "total": 7, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 23, "annotation": "n_glycosylation_sequon", "start_pos": 21 }, { "end_pos": 122, "annotation": "n_glycosylation_sequon", "start_pos": 120 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156628.1", "id": "NP_001156628.1", "database": "RefSeq" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000006867", "id": "ENSRNOG00000006867", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/QVPYCNS/", "id": "QVPYCNS", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "id": "IPR036388", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "id": "IPR036390", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032928", "id": "IPR032928", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006715", "id": "IPR006715", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000418", "id": "IPR000418", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF04621", "id": "PF04621", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00178", "id": "PF00178", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849:SF196", "id": "PTHR11849:SF196", "database": "PANTHER" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/362733", "id": "362733", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1312007", "id": "1312007", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2JTM3", "disease": [], "mass": { "monoisotopic_mass": 55071.0, "chemical_mass": 55071.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM3", "name": "Etv1.", "locus": { "end_pos": 58558631, "start_pos": 58467254, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000006867", "id": "ENSRNOG00000006867", "database": "Ensembl Gene" } ] } } ] }