{ "uniprot_canonical_ac": "A0A0G2JTK4-1", "sequence": { "header": "tr|A0A0G2JTK4-1|A0A0G2JTK4_RAT Isoform 1 of Protein phosphatase 6, regulatory subunit 1 OS=Rattus norvegicus OX=10116 GN=Ppp6r1 PE=1 SV=1 CANONICAL=A0A0G2JTK4-1", "length": 886, "sequence": "MDFLGVDSNQRNRIGGVGITIGFPKGAMFWKFDLHTSSHLDTLLEKEDLSLPELLDEEDVLQECKVVNQKLLDFLLQPSHLQAMVAWVTQEPSASGEERLRYKYPSVACEILTSDVPQINDALGADESLLNRLYGFLQSGDSLNPLLASFFSKVMGILINRKTDQLVSFLRKKDDFVDLLLRHIGTSAIMDLLLRLLTCVERPQLRQDVFNWLNEEKIVQRLIEQIHPSKDDNQHSNASQSLCDIIRLSREQMIQGQDSSEPDQLLATLEKQETIEQLLSNMFEGEQCQSVIVSGIQVLLTLLEPRRPRSDSVTMNNFFSSVDGQLELLAQGALDNALSSMGALHALRPRLDRFHQLLLEPPKLEPLQMTWGSLAPPLGNTRLHVVKLLASALSTNAAALTQELLVLDVPNTLLDLFFHYVFNNFLHAQVEVCVSAMLSSGPPPDSSPETPVPNPIVKHLLQHCRLVERILASWEENDRVQSGGGPRKGYMGHLTRVANAVVQNAEQGPNAEQLGQLLKELPEEQQQRWEAFVSGPLAETNKKNTVDLVNTHHLHSSSDDEDDRLKEFNFPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTANITFSLNADDENPNANLLEICYKDRIQQFDDEEEDEEEGHGSAESDGEYGAWQGSQPVRASQASQPPGVRSGGSTDSEEEEEEEEEEDEDEGADQAACGRTSPSSFPSPGPQPSGPSWTATFDPVPMDAPTGPPVSKEADISSIQILSSPPAHDSPQLRSQDPTHPSAPQEVTDSSKVAEPLAPCQALVSVADVQATLHGMRSAPSYLDSATRDPSTSVPDFKAHQSPQTMEGKKSPEHLGLPQNQSAQALEMPNGSTPGGPITSGSQ" }, "uniprot_id": "A0A0G2JTK4_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X2" ], "uniprotkb": [ "Protein phosphatase 6, regulatory subunit 1" ] }, "gene": { "refseq": [ "Ppp6r1", "RGD1311409", "Saps1" ], "uniprotkb": [ "Ppp6r1", "RGD1311409", "Saps1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTK4", "id": "A0A0G2JTK4", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Protein phosphatase 6, regulatory subunit 1." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTK4/publications", "id": "A0A0G2JTK4", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" }, { "title": "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16641100", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTK4/publications", "id": "A0A0G2JTK4", "database": "UniProtKB" } ], "authors": "Wang G., Shen R.F., Knepper M.A., Shen R.-F., Hoffert J.D., Pisitkun T.", "date": "2006", "pmid": "16641100" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTK4#A0A0G2JTK4-1", "isoform_ac": "A0A0G2JTK4-1", "locus": { "end_pos": 72757487, "start_pos": 72783247, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000082423", "id": "ENSRNOT00000082423", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068745", "id": "ENSRNOP00000068745", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JTK4-1|A0A0G2JTK4_RAT Isoform 1 of Protein phosphatase 6, regulatory subunit 1 OS=Rattus norvegicus OX=10116 GN=Ppp6r1 PE=1 SV=1 CANONICAL=A0A0G2JTK4-1", "length": 886, "sequence": "MDFLGVDSNQRNRIGGVGITIGFPKGAMFWKFDLHTSSHLDTLLEKEDLSLPELLDEEDVLQECKVVNQKLLDFLLQPSHLQAMVAWVTQEPSASGEERLRYKYPSVACEILTSDVPQINDALGADESLLNRLYGFLQSGDSLNPLLASFFSKVMGILINRKTDQLVSFLRKKDDFVDLLLRHIGTSAIMDLLLRLLTCVERPQLRQDVFNWLNEEKIVQRLIEQIHPSKDDNQHSNASQSLCDIIRLSREQMIQGQDSSEPDQLLATLEKQETIEQLLSNMFEGEQCQSVIVSGIQVLLTLLEPRRPRSDSVTMNNFFSSVDGQLELLAQGALDNALSSMGALHALRPRLDRFHQLLLEPPKLEPLQMTWGSLAPPLGNTRLHVVKLLASALSTNAAALTQELLVLDVPNTLLDLFFHYVFNNFLHAQVEVCVSAMLSSGPPPDSSPETPVPNPIVKHLLQHCRLVERILASWEENDRVQSGGGPRKGYMGHLTRVANAVVQNAEQGPNAEQLGQLLKELPEEQQQRWEAFVSGPLAETNKKNTVDLVNTHHLHSSSDDEDDRLKEFNFPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTANITFSLNADDENPNANLLEICYKDRIQQFDDEEEDEEEGHGSAESDGEYGAWQGSQPVRASQASQPPGVRSGGSTDSEEEEEEEEEEDEDEGADQAACGRTSPSSFPSPGPQPSGPSWTATFDPVPMDAPTGPPVSKEADISSIQILSSPPAHDSPQLRSQDPTHPSAPQEVTDSSKVAEPLAPCQALVSVADVQATLHGMRSAPSYLDSATRDPSTSVPDFKAHQSPQTMEGKKSPEHLGLPQNQSAQALEMPNGSTPGGPITSGSQ" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JTK4#D3ZG37-1", "isoform_ac": "D3ZG37-1", "locus": { "end_pos": 72767489, "start_pos": 72783247, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000024400", "id": "ENSRNOT00000024400", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000024400", "id": "ENSRNOP00000024400", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZG37-1|A0A0G2JTK4_RAT Computationally mapped isoform of Protein phosphatase 6, regulatory subunit 1 OS=Rattus norvegicus OX=10116 GN=Ppp6r1 PE=1 SV=1 CANONICAL=A0A0G2JTK4-1", "length": 859, "sequence": "MFWKFDLHTSSHLDTLLEKEDLSLPELLDEEDVLQECKVVNQKLLDFLLQPSHLQAMVAWVTQEPSASGEERLRYKYPSVACEILTSDVPQINDALGADESLLNRLYGFLQSGDSLNPLLASFFSKVMGILINRKTDQLVSFLRKKDDFVDLLLRHIGTSAIMDLLLRLLTCVERPQLRQDVFNWLNEEKIVQRLIEQIHPSKDDNQHSNASQSLCDIIRLSREQMIQGQDSSEPDQLLATLEKQETIEQLLSNMFEGEQCQSVIVSGIQVLLTLLEPRRPRSDSVTMNNFFSSVDGQLELLAQGALDNALSSMGALHALRPRLDRFHQLLLEPPKLEPLQMTWGSLAPPLGNTRLHVVKLLASALSTNAAALTQELLVLDVPNTLLDLFFHYVFNNFLHAQVEVCVSAMLSSGPPPDSSPETPVPNPIVKHLLQHCRLVERILASWEENDRVQSGGGPRKGYMGHLTRVANAVVQNAEQGPNAEQLGQLLKELPEEQQQRWEAFVSGPLAETNKKNTVDLVNTHHLHSSSDDEDDRLKEFNFPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTANITFSLNADDENPNANLLEICYKDRIQQFDDEEEDEEEGHGSAESDGEYGAWQGSQPVRASQASQPPGVRSGGSTDSEEEEEEEEEEDEDEGADQAACGRTSPSSFPSPGPQPSGPSWTATFDPVPMDAPTGPPVSKEADISSIQILSSPPAHDSPQLRSQDPTHPSAPQEVTDSSKVAEPLAPCQALVSVADVQATLHGMRSAPSYLDSATRDPSTSVPDFKAHQSPQTMEGKKSPEHLGLPQNQSAQALEMPNGSTPGGPITSGSQ" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-204005", "resource": "Reactome", "id": "R-RNO-204005", "name": "COPII-mediated vesicle transport" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q7TSI3-1", "protein_name": "Serine/threonine-protein phosphatase 6 regulatory subunit 1; SAPS domain family member 1.", "sequence": { "length": 856, "sequence": "MFWKFDLHTSSHLDTLLEKEDLSLPELLDEEDVLQECKVVNRKLLDFLLQPSHLQAMVAWVTQEPPASGEERLRYKYPSVACEILTSDVPQINDALGADESLLNRLYGFLQSGDSLNPLLASFFSKVMGILINRKTDQLVSFLRKKDDFVDLLLRHIGTSAIMDLLLRLLTCVERPQLRQDVFNWLNEEKIVQRLIEQIHPSKDDNQHSNASQSLCDIIRLSREQMIQGQDSPEPDQLLATLEKQETIEQLLSNMFEGEQCQSVIVSGIQVLLTLLEPRRPRSDSVTMNNFFSSVDGQLELLAQGALDDALSSMGALHALRPRLDRFHQLLLEPPKLEPLQMTWGSLAPPLGNTRLHVVKLLASALSANAAALTQELLVLDVPNTLLDLFFHYVFNNFLHAQVEVCVSAMLSSGPPPDSSSETPVPNPIVKHLLQHCRLVERILASWEENDRVQSGGGPRKGYMGHLTRVANAVVQNAEQGPNAEQLGQLLKELPEEQQQRWEAFVSGPLAETNKKNTVDLVNTHHLHSSSDDEDDRLKEFNFPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTANITFSLNADDENPNANLLEICYKDRIQQFDDEEEEEEEGQGSAESDGEYGAWQGSQPVRASQASQPPGVRSGGSTDSEEEDEEEDEEEDEGAEQAACGRTSPSSFPSPSTQPPGPSWTATFDTVPMDAPTGPPVSKEADMSSIQIPSSPPAHGSPQLRSQDPTHPSAPQEVTDSSKVAEPLAPCQALVSVADVQATLHGMRSAPSSLDSATRDPSTSVPDFKAHQSPQTMEGKRSPEHLGLPQSQSALEMPNGSTPGGPISSGSQ" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2JTK4/", "id": "A0A0G2JTK4", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/86982", "id": "86982", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q9UPN7-1", "protein_name": "Serine/threonine-protein phosphatase 6 regulatory subunit 1; SAPS domain family member 1.", "sequence": { "length": 881, "sequence": "MFWKFDLHTSSHLDTLLEREDLSLPELLDEEDVLQECKVVNRKLLDFLLQPPHLQAMVAWVTQEPPDSGEERLRYKYPSVACEILTSDVPQINDALGADESLLNRLYGFLQSTGSLNPLLASFFSKVMGILINRKTDQLVSFLRKKDDFVDLLLQHIGTSAIMDLLLRLLTCVERPQLRQDVVNWLNEEKIVQRLIEQIHPSKDENQHSNASQSLCDIIRLSREQMIQVQDSPEPDQLLATLEKQETIEQLLSNMFEGEQSQSVIVSGIQVLLTLLEPRRPRSESVTVNSFFSSVDGQLELLAQGALESTVSSVGALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLLASALSANDAALTHELLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLSLGPPPDSSPETPIQNPVVKHLLQQCRLVERILTSWEENDRVQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELPSEQQEQWEAFVSGPLAETNKKNMVDLVNTHHLHSSSDDEDDRLKEFNFPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTANITFSLNADDENPNANLLEICYKDRIQQFDDDEEEEDEEEAQGSGESDGEDGAWQGSQLARGARLGQPPGVRSGGSTDSEDEEEEDEEEEEDEEGIGCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQATFHGIRSAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSAPEGPASPGSQ" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2JTK4/", "id": "A0A0G2JTK4", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/86982", "id": "86982", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006228337.1", "ac": "XP_006228337.1", "name": "serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X2.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017048", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTK4", "id": "A0A0G2JTK4", "database": "UniProtKB" } ], "name": "Rho GTPase binding", "id": "GO:0017048" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019903", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTK4", "id": "A0A0G2JTK4", "database": "UniProtKB" } ], "name": "protein phosphatase binding", "id": "GO:0019903" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTK4", "id": "A0A0G2JTK4", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043666", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTK4", "id": "A0A0G2JTK4", "database": "UniProtKB" } ], "name": "regulation of phosphoprotein phosphatase activity", "id": "GO:0043666" } ], "total": 1, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 239, "annotation": "n_glycosylation_sequon", "start_pos": 237 }, { "end_pos": 621, "annotation": "n_glycosylation_sequon", "start_pos": 619 }, { "end_pos": 865, "annotation": "n_glycosylation_sequon", "start_pos": 863 }, { "end_pos": 875, "annotation": "n_glycosylation_sequon", "start_pos": 873 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006228337.1", "id": "XP_006228337.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-204005", "id": "R-RNO-204005", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000018090", "id": "ENSRNOG00000018090", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/MTWGSLA/", "id": "MTWGSLA", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "id": "IPR016024", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007587", "id": "IPR007587", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF04499", "id": "PF04499", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12634", "id": "PTHR12634", "database": "PANTHER" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/361502", "id": "361502", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311409", "id": "1311409", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2JTK4", "disease": [], "mass": { "monoisotopic_mass": 97741.0, "chemical_mass": 97741.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTK4", "name": "Ppp6r1; RGD1311409; Saps1.", "locus": { "end_pos": 72784482, "start_pos": 72756809, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000018090", "id": "ENSRNOG00000018090", "database": "Ensembl Gene" } ] } } ] }