{ "uniprot_canonical_ac": "A0A0G2JTC9-1", "sequence": { "header": "tr|A0A0G2JTC9-1|A0A0G2JTC9_RAT Isoform 1 of F-box and leucine-rich repeat protein 5 OS=Rattus norvegicus OX=10116 GN=Fbxl5 PE=4 SV=1 CANONICAL=A0A0G2JTC9-1", "length": 690, "sequence": "MAPFPDEVDVFTAPHWRMKQLVGRYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNECEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNQAEERQKVFKYSVDEKSDAEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSTKWSQLAKTGSLWKHLYPVHWARGDWYSGPATELDTEPDEEWVRSRKDESRAFQEWDEDADIDESEESAEESVAISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDMALEKISRALGVLTSHQSGVLKSAGKTTSTPWTNKDITMPSTTQYACLHNLTNKGVGEEIDSEHTWTEPVSSESFTPPYVWMLDAEDLADIEDAVEWRHRNVESLCVMETASNFGCSSSGCYSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSALPAASAVCRKALRTTLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTVTGAGLQDLVSACPSLNDEYFYYCDNINGPHADTASGCQNLQCGFRACCRSGE" }, "uniprot_id": "A0A0G2JTC9_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "F-box/LRR-repeat protein 5 isoform X1" ], "uniprotkb": [ "F-box and leucine-rich repeat protein 5" ] }, "gene": { "refseq": [ "Fbxl5" ], "uniprotkb": [ "Fbxl5" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTC9", "id": "A0A0G2JTC9", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "F-box and leucine-rich repeat protein 5." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTC9#A0A0G2JTC9-1", "isoform_ac": "A0A0G2JTC9-1", "locus": { "end_pos": 71852716, "start_pos": 71890433, "chromosome": "14", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000078326", "id": "ENSRNOT00000078326", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068659", "id": "ENSRNOP00000068659", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JTC9-1|A0A0G2JTC9_RAT Isoform 1 of F-box and leucine-rich repeat protein 5 OS=Rattus norvegicus OX=10116 GN=Fbxl5 PE=4 SV=1 CANONICAL=A0A0G2JTC9-1", "length": 690, "sequence": "MAPFPDEVDVFTAPHWRMKQLVGRYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNECEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNQAEERQKVFKYSVDEKSDAEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSTKWSQLAKTGSLWKHLYPVHWARGDWYSGPATELDTEPDEEWVRSRKDESRAFQEWDEDADIDESEESAEESVAISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDMALEKISRALGVLTSHQSGVLKSAGKTTSTPWTNKDITMPSTTQYACLHNLTNKGVGEEIDSEHTWTEPVSSESFTPPYVWMLDAEDLADIEDAVEWRHRNVESLCVMETASNFGCSSSGCYSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSALPAASAVCRKALRTTLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTVTGAGLQDLVSACPSLNDEYFYYCDNINGPHADTASGCQNLQCGFRACCRSGE" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JTC9#D3ZA08-1", "isoform_ac": "D3ZA08-1", "locus": { "end_pos": 71852767, "start_pos": 71890433, "chromosome": "14", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000064636", "id": "ENSRNOT00000064636", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000062042", "id": "ENSRNOP00000062042", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZA08-1|A0A0G2JTC9_RAT Computationally mapped isoform of F-box and leucine-rich repeat protein 5 OS=Rattus norvegicus OX=10116 GN=Fbxl5 PE=4 SV=1 CANONICAL=A0A0G2JTC9-1", "length": 637, "sequence": "MKQLVGRYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNECEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNQAEERQKVFKYSVDEKSDAEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSTKWSQLAKTGSLWKHLYPVHWARGDWYSGPATELDTEPDEEWVRSRKDESRAFQEWDEDADIDESEESAEESVAISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMSLRHLDLSGCEKITDMALEKISRALGVLTSHQSGVLKSAGKTTSTPWTNKDITMPSTTQYACLHNLTNKGVGEEIDSEHTWTEPVSSESFTPPYVWMLDAEDLADIEDAVEWRHRNVESLCVMETASNFGCSSSGCYSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSALPAASAVCRKALRTTLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTVTGAGLQDLVSACPSLNDEYFYYCDNINGPHADTASGCQNLQCGFRACCRSGE" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8951664", "resource": "Reactome", "id": "R-RNO-8951664", "name": "Neddylation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "resource": "Reactome", "id": "R-RNO-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-917937", "resource": "Reactome", "id": "R-RNO-917937", "name": "Iron uptake and transport" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q9UKA1-1", "protein_name": "F-box/LRR-repeat protein 5; FBL5; p45SKP2-like protein; F-box and leucine-rich repeat protein 5.", "sequence": { "length": 691, "sequence": "MAPFPEEVDVFTAPHWRMKQLVGLYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKITSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINGPHADTASGCQNLQCGFRACCRSGE" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/8129", "id": "8129", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2JTC9/", "id": "A0A0G2JTC9", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q8C2S5-1", "protein_name": "F-box/LRR-repeat protein 5; F-box and leucine-rich repeat protein 5.", "sequence": { "length": 690, "sequence": "MAPFPDEVDVFTAPHWRMKQLVGRYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNQAEERQKVLKYSVDEKADTEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSTKWSQLAKTGSLWKHLYPVHWARGDWYSGPATELDTEPDEEWVRNRKDESRAFQEWDEDADIDESEESAEESVAISIAQMEKRVLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDMALEKISRALGVLTSHQSGFLKSAGKAASTPWTSKDITMPSTTQYACLHNLTDKGIGEEIDNEHSWTEPVSSESLTSPYVWMLDAEDLADIEDAVEWRHRNVESLCVMETASNFGCSSSGCYSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMTTLPATSAMCRKALRTTLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRALTLGGGLPYLEHLNLSGCLTVTGAGLQDLVSACPSLNDEYFYYCDNINGPHADTASGCQNLQCGFRACCRSGE" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/8129", "id": "8129", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006251138.1", "ac": "XP_006251138.1", "name": "F-box/LRR-repeat protein 5 isoform X1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTC9", "id": "A0A0G2JTC9", "database": "UniProtKB" } ], "name": "iron ion binding", "id": "GO:0005506" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTC9", "id": "A0A0G2JTC9", "database": "UniProtKB" } ], "name": "SCF ubiquitin ligase complex", "id": "GO:0019005" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTC9", "id": "A0A0G2JTC9", "database": "UniProtKB" } ], "name": "perinuclear region of cytoplasm", "id": "GO:0048471" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTC9", "id": "A0A0G2JTC9", "database": "UniProtKB" } ], "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055072", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTC9", "id": "A0A0G2JTC9", "database": "UniProtKB" } ], "name": "iron ion homeostasis", "id": "GO:0055072" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTC9", "id": "A0A0G2JTC9", "database": "UniProtKB" } ], "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTC9", "id": "A0A0G2JTC9", "database": "UniProtKB" } ], "name": "protein ubiquitination", "id": "GO:0016567" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903364", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTC9", "id": "A0A0G2JTC9", "database": "UniProtKB" } ], "name": "positive regulation of cellular protein catabolic process", "id": "GO:1903364" } ], "total": 5, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 35, "annotation": "n_glycosylation_sequon", "start_pos": 33 }, { "end_pos": 450, "annotation": "n_glycosylation_sequon", "start_pos": 448 }, { "end_pos": 633, "annotation": "n_glycosylation_sequon", "start_pos": 631 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006251138.1", "id": "XP_006251138.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8951664", "id": "R-RNO-8951664", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "id": "R-RNO-983168", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-917937", "id": "R-RNO-917937", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000005261", "id": "ENSRNOG00000005261", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/GRAYQEW/", "id": "GRAYQEW", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR012312", "id": "IPR012312", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "id": "IPR001611", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "id": "IPR032675", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006553", "id": "IPR006553", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "id": "IPR036047", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "id": "IPR001810", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF01814", "id": "PF01814", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF13516", "id": "PF13516", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF12937", "id": "PF12937", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/305424", "id": "305424", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1306887", "id": "1306887", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2JTC9", "disease": [], "mass": { "monoisotopic_mass": 77818.0, "chemical_mass": 77818.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTC9", "name": "Fbxl5.", "locus": { "end_pos": 71891143, "start_pos": 71852682, "chromosome": "14", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000005261", "id": "ENSRNOG00000005261", "database": "Ensembl Gene" } ] } } ] }