{ "uniprot_canonical_ac": "A0A0G2JT20-1", "sequence": { "header": "tr|A0A0G2JT20-1|A0A0G2JT20_RAT Isoform 1 of MIER family member 2 OS=Rattus norvegicus OX=10116 GN=Mier2 PE=4 SV=1 CANONICAL=A0A0G2JT20-1", "length": 509, "sequence": "MGSADHQFHLTELLTQNYSLQEGCAEALQGPDRPEEELDKDFIDQSSDMPLDELLALYGYESSEPISEQESEGGDTAPPLPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFHNQSGSRFLSGDNGPGSSASSDTEEDALPANKCKKEIMVGPQFQADLNILHLNRHCDKIYENEDQLLWSPTVLPEREVEEFLYRAVKRRWQEMAGPQIPEGEVVKDSEQALYELVKCNFNVEEALRRLRFNVKVIRDGLCAWSEEECRNFEHGFRVHGKNFHLIQANKVRTRSVGECVEYYYLWKKSERYDYFAQQTRLGRRKFVSSGTTDTEQDLDGLDPDGHARLQSETRVPVEPLSADIEAGGLDQPGVDSDDLPSSEPGPSPFQQLDEPPAVPSLQQPTSLATSAELPLTELPPAAAAPEPATSPRLAVDLALPEELPLVSSPVALNGDPAEPMAPAQVALSVTEFGLIGIGDVNPFLTGHPACPASTLHAEPLSQCNVMTC" }, "uniprot_id": "A0A0G2JT20_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "mesoderm induction early response protein 2 isoform X6" ], "uniprotkb": [ "MIER family member 2" ] }, "gene": { "refseq": [ "Mier2", "RGD1307278" ], "uniprotkb": [ "Mier2", "RGD1307278" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JT20", "id": "A0A0G2JT20", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "MIER family member 2." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JT20#A0A0G2JT20-1", "isoform_ac": "A0A0G2JT20-1", "locus": { "end_pos": 13045216, "start_pos": 13054756, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000090048", "id": "ENSRNOT00000090048", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068538", "id": "ENSRNOP00000068538", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JT20-1|A0A0G2JT20_RAT Isoform 1 of MIER family member 2 OS=Rattus norvegicus OX=10116 GN=Mier2 PE=4 SV=1 CANONICAL=A0A0G2JT20-1", "length": 509, "sequence": "MGSADHQFHLTELLTQNYSLQEGCAEALQGPDRPEEELDKDFIDQSSDMPLDELLALYGYESSEPISEQESEGGDTAPPLPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFHNQSGSRFLSGDNGPGSSASSDTEEDALPANKCKKEIMVGPQFQADLNILHLNRHCDKIYENEDQLLWSPTVLPEREVEEFLYRAVKRRWQEMAGPQIPEGEVVKDSEQALYELVKCNFNVEEALRRLRFNVKVIRDGLCAWSEEECRNFEHGFRVHGKNFHLIQANKVRTRSVGECVEYYYLWKKSERYDYFAQQTRLGRRKFVSSGTTDTEQDLDGLDPDGHARLQSETRVPVEPLSADIEAGGLDQPGVDSDDLPSSEPGPSPFQQLDEPPAVPSLQQPTSLATSAELPLTELPPAAAAPEPATSPRLAVDLALPEELPLVSSPVALNGDPAEPMAPAQVALSVTEFGLIGIGDVNPFLTGHPACPASTLHAEPLSQCNVMTC" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JT20#D3ZR39-1", "isoform_ac": "D3ZR39-1", "locus": { "end_pos": 13039800, "start_pos": 13053566, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000067771", "id": "ENSRNOT00000067771", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000060254", "id": "ENSRNOP00000060254", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZR39-1|A0A0G2JT20_RAT Computationally mapped isoform of MIER family member 2 OS=Rattus norvegicus OX=10116 GN=Mier2 PE=4 SV=1 CANONICAL=A0A0G2JT20-1", "length": 398, "sequence": "MAEASSLERQSPRVASCLVHSLCPREPSLQTTAVVSMGSADHQFHLTELLTQNYSLQEGCAEALQGPDRPEEELDKDFIDQSSDMPLDELLALYGYESSEPISEQESEGGDTAPPLPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFHNQSGSRFLSGDNGPGSSASSDTEEDALPANKCKKEIMVGPQFQADLNILHLNRHCDKIYENEDQLLWSPTVLPEREVEEFLYRAVKRRWQEMAGPQIPEGEVVKDSEQALYELVKCNFNVEEALRRLRFNVKVIRDGLCAWSEEECRNFEHGFRVHGKNFHLIQANKVRTRSVGECVEYYYLWKKSERYDYFAQQTRLGRRKFVSSGTTDTEQDLDGLDPDGHARLQSETRVPVGEST" } } ], "pathway": [], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q8N344-1", "protein_name": "Mesoderm induction early response protein 2; Mi-er2.", "sequence": { "length": 545, "sequence": "MAEASSLGRQSPRVVSCLEHSLCPGEPGLQTTAVVSMGSGDHQFNLAEILSQNYSVRGECEEASRCPDKPKEELEKDFISQSNDMPFDELLALYGYEASDPISDRESEGGDVAPNLPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPNRSGSRFLADEDREPGSSASSDTEEDSLPANKCKKEIMVGPQFQADLSNLHLNRHCEKIYENEDQLLWDPSVLPEREVEEFLYRAVKRRWHEMAGPQLPEGEAVKDSEQALYELVKCNFNVEEALRRLRFNVKVIRDGLCAWSEEECRNFEHGFRVHGKNFHLIQANKVRTRSVGECVEYYYLWKKSERYDYFAQQTRLGRRKYVPSGTTDADQDLDGSDPDGPGRPRPEQDTLTGMRTDPLSVDGTAGGLDEPGVASDGLPSSEPGPCSFQQLDESPAVPLSHRPPALADPASYQPAVTAPEPDASPRLAVDFALPKELPLISSHVDLSGDPEETVAPAQVALSVTEFGLIGIGDVNPFLAAHPTCPAPGLHSEPLSHCNVMTC" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/18941", "id": "18941", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q3U3N0-1", "protein_name": "Mesoderm induction early response protein 2; Mi-er2.", "sequence": { "length": 541, "sequence": "MAEASSLERQSPRVASCLVHSLCPREPSLQTTAVVSMGSADHQFNLAELLTQNYNLQEGCAEAPQCPDKPEEELDKDFIDQSSDMPLDELLALYGYESSDPISEQESEGGDTAPALPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFHNQSGSRFLAGDNGPGSSASSDTEEDALPANKCKKEIMVGPQFQADLNILHLNRHCDKIYENEDQLLWSPSVLPEREVEEFLYRAVKRRWQEMAGPQIPEGEVVKDSEQALYELVKCNFNVEEALRRLRFNVKVIRDGLCAWSEEECRNFEHGFRVHGKNFHLIQANKVRTRSVGECVEYYYLWKKSERYDYFAQQTRLGRRKFVSSGTTDTEQDLDGLDPDGHARLHSEAGVPVEPLNVDIEAGGLDQPGVGSDDLPSSEPGPRPFQQLDEPPAVPSLQQPTSLAASAELPPAAAAAPEPGTSPRLPVDLALPEELPLVSSPVALSEDTAEPMAPAQVALSVTEFGLIGIGDVNPFLTGHPACPTSTLHSEPLSQCNVMTC" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/18941", "id": "18941", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017450404.1", "ac": "XP_017450404.1", "name": "mesoderm induction early response protein 2 isoform X6.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JT20", "id": "A0A0G2JT20", "database": "UniProtKB" } ], "name": "transcription corepressor activity", "id": "GO:0003714" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JT20", "id": "A0A0G2JT20", "database": "UniProtKB" } ], "name": "histone deacetylase binding", "id": "GO:0042826" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001103", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JT20", "id": "A0A0G2JT20", "database": "UniProtKB" } ], "name": "RNA polymerase II repressing transcription factor binding", "id": "GO:0001103" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JT20", "id": "A0A0G2JT20", "database": "UniProtKB" } ], "name": "DNA binding", "id": "GO:0003677" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004407", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JT20", "id": "A0A0G2JT20", "database": "UniProtKB" } ], "name": "histone deacetylase activity", "id": "GO:0004407" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JT20", "id": "A0A0G2JT20", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JT20", "id": "A0A0G2JT20", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JT20", "id": "A0A0G2JT20", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JT20", "id": "A0A0G2JT20", "database": "UniProtKB" } ], "name": "protein-containing complex", "id": "GO:0032991" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JT20", "id": "A0A0G2JT20", "database": "UniProtKB" } ], "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016575", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JT20", "id": "A0A0G2JT20", "database": "UniProtKB" } ], "name": "histone deacetylation", "id": "GO:0016575" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 19, "annotation": "n_glycosylation_sequon", "start_pos": 17 }, { "end_pos": 127, "annotation": "n_glycosylation_sequon", "start_pos": 125 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017450404.1", "id": "XP_017450404.1", "database": "RefSeq" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000000175", "id": "ENSRNOG00000000175", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "id": "IPR009057", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001005", "id": "IPR001005", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR040138", "id": "IPR040138", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000949", "id": "IPR000949", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017884", "id": "IPR017884", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF01448", "id": "PF01448", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00249", "id": "PF00249", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10865", "id": "PTHR10865", "database": "PANTHER" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/362841", "id": "362841", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307278", "id": "1307278", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2JT20", "disease": [], "mass": { "monoisotopic_mass": 55998.0, "chemical_mass": 55998.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JT20", "name": "Mier2; RGD1307278.", "locus": { "end_pos": 13055632, "start_pos": 13039781, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000000175", "id": "ENSRNOG00000000175", "database": "Ensembl Gene" } ] } } ] }