{
    "uniprot_canonical_ac": "A0A0G2JSL0-1", 
    "sequence": {
        "header": "tr|A0A0G2JSL0-1|A0A0G2JSL0_RAT Isoform 1 of Proteasome subunit beta  OS=Rattus norvegicus OX=10116 GN=LOC100360846 PE=3 SV=1 CANONICAL=A0A0G2JSL0-1", 
        "length": 238, 
        "sequence": "MAAALAVRGAISAPAFGPEALTPDWENREVSTGTTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDHIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKDECLQFTANALALAMERDGSSGGVIRLAAIQQSGVERQVLLGDQIPKVTISTLPPP"
    }, 
    "uniprot_id": "A0A0G2JSL0_RAT", 
    "enzyme_annotation": [
        {
            "ec": "3.4.25.1", 
            "activity": "Cleavage of peptide bonds with very broad specificity."
        }, 
        {
            "ec": "3.4.25.1", 
            "activity": ""
        }
    ], 
    "synonyms": {
        "protein": {
            "refseq": [
                "uncharacterized protein LOC100360846", 
                "proteasome subunit beta type-6"
            ], 
            "uniprotkb": [
                "Proteasome subunit beta", 
                "3.4.25.1"
            ]
        }, 
        "gene": {
            "refseq": [], 
            "uniprotkb": [
                "LOC100360846", 
                "rCG_63409"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JSL0", 
                    "id": "A0A0G2JSL0", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "Proteasome subunit beta; 3.4.25.1."
    }, 
    "publication": [], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JSL0#A0A0G2JSL0-1", 
            "isoform_ac": "A0A0G2JSL0-1", 
            "locus": {
                "end_pos": 96032004, 
                "start_pos": 96032717, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000015746", 
                        "id": "ENSRNOT00000015746", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000015747", 
                        "id": "ENSRNOP00000015747", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0G2JSL0-1|A0A0G2JSL0_RAT Isoform 1 of Proteasome subunit beta  OS=Rattus norvegicus OX=10116 GN=LOC100360846 PE=3 SV=1 CANONICAL=A0A0G2JSL0-1", 
                "length": 238, 
                "sequence": "MAAALAVRGAISAPAFGPEALTPDWENREVSTGTTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDHIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKDECLQFTANALALAMERDGSSGGVIRLAAIQQSGVERQVLLGDQIPKVTISTLPPP"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:100360846", 
            "resource": "KEGG Pathway", 
            "id": "rno:100360846", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169091", 
            "resource": "Reactome", 
            "id": "R-RNO-1169091", 
            "name": "Activation of NF-kappaB in B cells"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1234176", 
            "resource": "Reactome", 
            "id": "R-RNO-1234176", 
            "name": "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1236978", 
            "resource": "Reactome", 
            "id": "R-RNO-1236978", 
            "name": "Cross-presentation of soluble exogenous antigens (endosomes)"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4641258", 
            "resource": "Reactome", 
            "id": "R-RNO-4641258", 
            "name": "Degradation of DVL"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-195253", 
            "resource": "Reactome", 
            "id": "R-RNO-195253", 
            "name": "Degradation of beta-catenin by the destruction complex"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9020702", 
            "resource": "Reactome", 
            "id": "R-RNO-9020702", 
            "name": "Interleukin-1 signaling"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-349425", 
            "resource": "Reactome", 
            "id": "R-RNO-349425", 
            "name": "Autodegradation of the E3 ubiquitin ligase COP1"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-350562", 
            "resource": "Reactome", 
            "id": "R-RNO-350562", 
            "name": "Regulation of ornithine decarboxylase (ODC)"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-450408", 
            "resource": "Reactome", 
            "id": "R-RNO-450408", 
            "name": "AUF1 (hnRNP D0) binds and destabilizes mRNA"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4608870", 
            "resource": "Reactome", 
            "id": "R-RNO-4608870", 
            "name": "Asymmetric localization of PCP proteins"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-202424", 
            "resource": "Reactome", 
            "id": "R-RNO-202424", 
            "name": "Downstream TCR signaling"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2871837", 
            "resource": "Reactome", 
            "id": "R-RNO-2871837", 
            "name": "FCERI mediated NF-kB activation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5358346", 
            "resource": "Reactome", 
            "id": "R-RNO-5358346", 
            "name": "Hedgehog ligand biogenesis"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5607761", 
            "resource": "Reactome", 
            "id": "R-RNO-5607761", 
            "name": "Dectin-1 mediated noncanonical NF-kB signaling"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5607764", 
            "resource": "Reactome", 
            "id": "R-RNO-5607764", 
            "name": "CLEC7A (Dectin-1) signaling"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5610780", 
            "resource": "Reactome", 
            "id": "R-RNO-5610780", 
            "name": "Degradation of GLI1 by the proteasome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5610785", 
            "resource": "Reactome", 
            "id": "R-RNO-5610785", 
            "name": "GLI3 is processed to GLI3R by the proteasome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5676590", 
            "resource": "Reactome", 
            "id": "R-RNO-5676590", 
            "name": "NIK-->noncanonical NF-kB signaling"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5632684", 
            "resource": "Reactome", 
            "id": "R-RNO-5632684", 
            "name": "Hedgehog 'on' state"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5658442", 
            "resource": "Reactome", 
            "id": "R-RNO-5658442", 
            "name": "Regulation of RAS by GAPs"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5668541", 
            "resource": "Reactome", 
            "id": "R-RNO-5668541", 
            "name": "TNFR2 non-canonical NF-kB pathway"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5687128", 
            "resource": "Reactome", 
            "id": "R-RNO-5687128", 
            "name": "MAPK6/MAPK4 signaling"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689603", 
            "resource": "Reactome", 
            "id": "R-RNO-5689603", 
            "name": "UCH proteinases"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689880", 
            "resource": "Reactome", 
            "id": "R-RNO-5689880", 
            "name": "Ub-specific processing proteases"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-68827", 
            "resource": "Reactome", 
            "id": "R-RNO-68827", 
            "name": "CDT1 association with the CDC6:ORC:origin complex"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-68949", 
            "resource": "Reactome", 
            "id": "R-RNO-68949", 
            "name": "Orc1 removal from chromatin"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-69017", 
            "resource": "Reactome", 
            "id": "R-RNO-69017", 
            "name": "CDK-mediated phosphorylation and removal of Cdc6"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-69601", 
            "resource": "Reactome", 
            "id": "R-RNO-69601", 
            "name": "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-382556", 
            "resource": "Reactome", 
            "id": "R-RNO-382556", 
            "name": "ABC-family proteins mediated transport"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-69481", 
            "resource": "Reactome", 
            "id": "R-RNO-69481", 
            "name": "G2/M Checkpoints"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8852276", 
            "resource": "Reactome", 
            "id": "R-RNO-8852276", 
            "name": "The role of GTSE1 in G2/M progression after G2 checkpoint"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8854050", 
            "resource": "Reactome", 
            "id": "R-RNO-8854050", 
            "name": "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8939902", 
            "resource": "Reactome", 
            "id": "R-RNO-8939902", 
            "name": "Regulation of RUNX2 expression and activity"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8948751", 
            "resource": "Reactome", 
            "id": "R-RNO-8948751", 
            "name": "Regulation of PTEN stability and activity"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8939236", 
            "resource": "Reactome", 
            "id": "R-RNO-8939236", 
            "name": "RUNX1 regulates transcription of genes involved in differentiation of HSCs"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8941858", 
            "resource": "Reactome", 
            "id": "R-RNO-8941858", 
            "name": "Regulation of RUNX3 expression and activity"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8951664", 
            "resource": "Reactome", 
            "id": "R-RNO-8951664", 
            "name": "Neddylation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", 
            "resource": "Reactome", 
            "id": "R-RNO-983168", 
            "name": "Antigen processing: Ubiquitination & Proteasome degradation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-174084", 
            "resource": "Reactome", 
            "id": "R-RNO-174084", 
            "name": "Autodegradation of Cdh1 by Cdh1:APC/C"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-174178", 
            "resource": "Reactome", 
            "id": "R-RNO-174178", 
            "name": "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-174154", 
            "resource": "Reactome", 
            "id": "R-RNO-174154", 
            "name": "APC/C:Cdc20 mediated degradation of Securin"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2467813", 
            "resource": "Reactome", 
            "id": "R-RNO-2467813", 
            "name": "Separation of Sister Chromatids"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-174184", 
            "resource": "Reactome", 
            "id": "R-RNO-174184", 
            "name": "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-187577", 
            "resource": "Reactome", 
            "id": "R-RNO-187577", 
            "name": "SCF(Skp2)-mediated degradation of p27/p21"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4641257", 
            "resource": "Reactome", 
            "id": "R-RNO-4641257", 
            "name": "Degradation of AXIN"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75815", 
            "resource": "Reactome", 
            "id": "R-RNO-75815", 
            "name": "Ubiquitin-dependent degradation of Cyclin D"
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q60692-1", 
            "protein_name": "Proteasome subunit beta type-6; 3.4.25.1; Proteasome delta chain; Macropain delta chain; Low molecular mass protein 19; Proteasome subunit Y; Multicatalytic endopeptidase complex delta chain.", 
            "sequence": {
                "length": 238, 
                "sequence": "MAAALAVRRAGSAPAFGPEALTPDWENREVSTGTTIMAVQFNGGVVLGADSRTTTGSYIANRVTDKLTPIHDHIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKDECLQFTANALALAMERDGSSGGVIRLAAIQESGVERQVLLGDQIPKFTIATLPPP"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0A0G2JSL0/", 
                    "id": "A0A0G2JSL0", 
                    "database": "OMA"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "P28072-1", 
            "protein_name": "Proteasome subunit beta type-6; 3.4.25.1; Proteasome delta chain; Macropain delta chain; Proteasome subunit Y; Multicatalytic endopeptidase complex delta chain.", 
            "sequence": {
                "length": 239, 
                "sequence": "MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0A0G2JSL0/", 
                    "id": "A0A0G2JSL0", 
                    "database": "OMA"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "refseq": {
        "url": "", 
        "ac": "", 
        "name": "uncharacterized protein LOC100360846; proteasome subunit beta type-6.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004175", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSL0", 
                                "id": "A0A0G2JSL0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endopeptidase activity", 
                        "id": "GO:0004175"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004298", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSL0", 
                                "id": "A0A0G2JSL0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "threonine-type endopeptidase activity", 
                        "id": "GO:0004298"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSL0", 
                                "id": "A0A0G2JSL0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSL0", 
                                "id": "A0A0G2JSL0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005839", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSL0", 
                                "id": "A0A0G2JSL0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "proteasome core complex", 
                        "id": "GO:0005839"
                    }
                ], 
                "total": 3, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSL0", 
                                "id": "A0A0G2JSL0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", 
                        "id": "GO:0043161"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010498", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSL0", 
                                "id": "A0A0G2JSL0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "proteasomal protein catabolic process", 
                        "id": "GO:0010498"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010499", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSL0", 
                                "id": "A0A0G2JSL0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "proteasomal ubiquitin-independent protein catabolic process", 
                        "id": "GO:0010499"
                    }
                ], 
                "total": 3, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001316812.1", 
            "id": "NP_001316812.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169091", 
            "id": "R-RNO-1169091", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1234176", 
            "id": "R-RNO-1234176", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1236978", 
            "id": "R-RNO-1236978", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4641258", 
            "id": "R-RNO-4641258", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-195253", 
            "id": "R-RNO-195253", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9020702", 
            "id": "R-RNO-9020702", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-349425", 
            "id": "R-RNO-349425", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-350562", 
            "id": "R-RNO-350562", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-450408", 
            "id": "R-RNO-450408", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4608870", 
            "id": "R-RNO-4608870", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-202424", 
            "id": "R-RNO-202424", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2871837", 
            "id": "R-RNO-2871837", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5358346", 
            "id": "R-RNO-5358346", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5607761", 
            "id": "R-RNO-5607761", 
            "database": "Reactome"
        }, 
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}