{
    "uniprot_canonical_ac": "A0A0G2JMH6-1", 
    "sequence": {
        "header": "tr|A0A0G2JMH6-1|A0A0G2JMH6_HUMAN Isoform 1 of HLA-DRA  OS=Homo sapiens OX=9606 GN=HLA-DRA PE=1 SV=1 CANONICAL=A0A0G2JMH6-1", 
        "length": 254, 
        "sequence": "MAISGVPVLGFFIIAVLMSAQESWAIKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDAPSPLPETTENVVCALGLTVGLVGIIIGTIFIIKGLRKSNAAERRGPL"
    }, 
    "uniprot_id": "A0A0G2JMH6_HUMAN", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "HLA class II histocompatibility antigen, DR alpha chain precursor", 
                "HLA class II histocompatibility antigen, DR alpha chain; histocompatibility antigen HLA-DR alpha; MHC class II antigen DRA"
            ], 
            "uniprotkb": [
                "HLA-DRA"
            ]
        }, 
        "gene": {
            "refseq": [
                "HLA-DRA", 
                "HLA-DRA1"
            ], 
            "uniprotkb": [
                "HLA-DRA", 
                "HLA-DRA1"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JMH6", 
                    "id": "A0A0G2JMH6", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "HLA-DRA."
    }, 
    "publication": [
        {
            "title": "Microglia in the dorsal raphe nucleus plays a potential role in both suicide facilitation and prevention in affective disorders.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/28229240", 
            "journal": "European archives of psychiatry and clinical neuroscience", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984.2", 
                    "id": "NP_061984.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Brisch R, Steiner J, Mawrin C, Krzyzanowska M, Jankowski Z, Gos T", 
            "date": "2017", 
            "pmid": "28229240"
        }, 
        {
            "title": "HLA-DRA/HLA-DRB5 polymorphism affects risk of sporadic ALS and survival in a southwest Chinese cohort.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/28131168", 
            "journal": "Journal of the neurological sciences", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984.2", 
                    "id": "NP_061984.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Yang X, Zheng J, Tian S, Chen Y, An R, Zhao Q, Xu Y", 
            "date": "2017", 
            "pmid": "28131168"
        }, 
        {
            "title": "Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNFalpha response: A diagnostic tool for immunosuppression?", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/28771573", 
            "journal": "PloS one", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984.2", 
                    "id": "NP_061984.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Winkler MS, Rissiek A, Priefler M, Schwedhelm E, Robbe L, Bauer A, Zahrte C, Zoellner C, Kluge S, Nierhaus A", 
            "date": "2017", 
            "pmid": "28771573"
        }, 
        {
            "title": "Quantitative Real-Time Polymerase Chain Reaction Measurement of HLA-DRA Gene Expression in Whole Blood Is Highly Reproducible and Shows Changes That Reflect Dynamic Shifts in Monocyte Surface HLA-DR Expression during the Course of Sepsis.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/27144640", 
            "journal": "PloS one", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984.2", 
                    "id": "NP_061984.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Cajander S, Tina E, Backman A, Magnuson A, Stralin K, Soderquist B, Kallman J", 
            "date": "2016", 
            "pmid": "27144640"
        }, 
        {
            "title": "Major Histocompatibility Complex Class II HLA-DRalpha Is Downregulated by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Lytic Transactivator RTA and MARCH8.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/27356905", 
            "journal": "Journal of virology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984.2", 
                    "id": "NP_061984.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Sun Z, Jha HC, Pei YG, Robertson ES", 
            "date": "2016", 
            "pmid": "27356905"
        }, 
        {
            "title": "HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/1448172", 
            "journal": "Nature", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984.2", 
                    "id": "NP_061984.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Riberdy JM, Newcomb JR, Surman MJ, Barbosa JA, Cresswell P", 
            "date": "1992", 
            "pmid": "1448172"
        }, 
        {
            "title": "The HIV core protein p24 inhibits interferon-gamma-induced increase of HLA-DR and cytochrome b heavy chain mRNA levels in the human monocyte-like cell line THP1.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/1905983", 
            "journal": "Cellular immunology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984.2", 
                    "id": "NP_061984.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Nong Y, Kandil O, Tobin EH, Rose RM, Remold HG", 
            "date": "1991", 
            "pmid": "1905983"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JMH6#A0A0G2JMH6-1", 
            "isoform_ac": "A0A0G2JMH6-1", 
            "locus": {
                "end_pos": 32447024, 
                "start_pos": 32450980, 
                "chromosome": "6", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000613328", 
                        "id": "ENST00000613328", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000479287", 
                        "id": "ENSP00000479287", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0G2JMH6-1|A0A0G2JMH6_HUMAN Isoform 1 of HLA-DRA  OS=Homo sapiens OX=9606 GN=HLA-DRA PE=1 SV=1 CANONICAL=A0A0G2JMH6-1", 
                "length": 254, 
                "sequence": "MAISGVPVLGFFIIAVLMSAQESWAIKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDAPSPLPETTENVVCALGLTVGLVGIIIGTIFIIKGLRKSNAAERRGPL"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:3122", 
            "resource": "KEGG Pathway", 
            "id": "hsa:3122", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984.2", 
            "annotation": "Low HLA-DRA expression is associated with sepsis. Publication Status: Online-Only", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984.2", 
                    "id": "NP_061984.2", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984.2", 
            "annotation": "This study demonstrated that only the non-suicidal depressed subgroup revealed significantly lower microglial reaction, i.e., a decreased density of HLA-DR positive microglia versus both depressed suicide victims and controls.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984.2", 
                    "id": "NP_061984.2", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984.2", 
            "annotation": "Case-control study in Han Chinese from the southwest of the country suggests that risk of ALS is increased by the AA genotype at rs9268856 in the HLA-DRA/HLA-DRB5 gene, but not by the SNPs rs9268877 in HLA-DRA/HLA-DRB5, rs1980493 in BTNL2 or rs302668 in RAB38/CTSC", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984.2", 
                    "id": "NP_061984.2", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984.2", 
            "annotation": "Kaposi's sarcoma-associated herpesvirus RTA not only downregulated HLA-DRalpha at the protein level through direct binding and degradation through the proteasome pathway but also indirectly downregulated the protein level of HLA-DRalpha by enhancing the expression of MARCH8, a member of the membrane-associated RING-CH (MARCH) proteins. Publication Status: Online-Only", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984.2", 
                    "id": "NP_061984.2", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984.2", 
            "annotation": "In this prospective study we evaluated dynamic changes in monocyte HLA-DR expression during sepsis in relation to changes in HLA-DRA gene expression and Class II transactivator (CIITA), measured by quantitative Real-Time Polymerase Chain Reaction (qRT-PCR). Publication Status: Online-Only", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984.2", 
                    "id": "NP_061984.2", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q6MG98-1", 
            "protein_name": "RCG60548; RT1 class II, D alpha; RT1-Da; RT1 class II, locus Da; Histocompatibility 2, class II antigen E alpha.", 
            "sequence": {
                "length": 255, 
                "sequence": "MATLGDLVIRFFFMAVLMSPQKSWAIREEHTIIQAEFYLSPDQNGEFMFDFDGDEIFHVDIKKSETIWRLEEFAQFASFEAQGALANIAVDKANLDIMIKRSNNTPDANVIPEVTVLPKSPVNLGEPNILICFIDKFSPPAVNVTWLRNGQPVTKGVSETVFLPREDHLFRKFHYLTFLPSTEDYYDCEVDHWGLEEPLRKHWEFEEKTLLPETKENVLCVLGLFVGLVGIVVGIVLIIKGLRKRNAVERRQGAL"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/7751", 
                    "id": "7751", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984.2", 
        "ac": "NP_061984.2", 
        "name": "HLA class II histocompatibility antigen, DR alpha chain precursor; HLA class II histocompatibility antigen, DR alpha chain; histocompatibility antigen HLA-DR alpha; MHC class II antigen DRA.", 
        "summary": "HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]."
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JMH6", 
                                "id": "A0A0G2JMH6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042613", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JMH6", 
                                "id": "A0A0G2JMH6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "MHC class II protein complex", 
                        "id": "GO:0042613"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JMH6", 
                                "id": "A0A0G2JMH6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "adaptive immune response", 
                        "id": "GO:0002250"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002504", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JMH6", 
                                "id": "A0A0G2JMH6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", 
                        "id": "GO:0002504"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 105, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 103
        }, 
        {
            "end_pos": 145, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 143
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984.2", 
            "id": "NP_061984.2", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:3122", 
            "id": "hsa:3122", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/TLICFID/", 
            "id": "TLICFID", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", 
            "id": "IPR007110", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", 
            "id": "IPR013783", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", 
            "id": "IPR036179", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR014745", 
            "id": "IPR014745", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003006", 
            "id": "IPR003006", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003597", 
            "id": "IPR003597", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011162", 
            "id": "IPR011162", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001003", 
            "id": "IPR001003", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF07654", 
            "id": "PF07654", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00993", 
            "id": "PF00993", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/3122", 
            "id": "3122", 
            "database": "GeneID"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0A0G2JMH6", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 28621.0, 
        "chemical_mass": 28621.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JMH6", 
            "name": "HLA-DRA; HLA-DRA1.", 
            "locus": {
                "end_pos": 32445046, 
                "start_pos": 32439842, 
                "chromosome": "6", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000204287", 
                        "id": "ENSG00000204287", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}