{ "uniprot_canonical_ac": "A0A0G2JDV3-1", "sequence": { "header": "tr|A0A0G2JDV3-1|A0A0G2JDV3_MOUSE Isoform 1 of Guanylate-binding protein 6 OS=Mus musculus OX=10090 GN=Gbp6 PE=1 SV=1 CANONICAL=A0A0G2JDV3-1", "length": 611, "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFIYNSMITINHQALEQLHYVTELTELIRAKSSPNPAGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDDYLENALKLIPGDKPRMQASNSCRECIRLFFPNRKCFVFDRPTHDKELLQKLDSITEDQLDPKFQEVTKAFVSYIFTYAKIKTLKEGIKVTGNRLGILVTTYVNAINSGAVPCLDDAVTTLAQRENSVAVQKAADHYSEQMAQRLRLPTETLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELIGENKELFLSKNEEASNKYCQEELDRLSKDFMENISTFFVPCGHKLYMDKREKIEHDYWQVPRKGVKASEVFQSFLQSQAFIESSILQADTALTAGEKAIAEERAQKVAAEKEQELLRQKQKEQQEYMEAQEKSHKENLEQLRRKLEQEREQDIKDHDMMLKKLMKDQKAFLEEGFKKKAEEMNKEIQQLRDVIKDKKRNTDRIKEALLNGFSTVLFHYLVRYLKHL" }, "uniprot_id": "A0A0G2JDV3_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "guanylate binding protein 6", "macrophage activation 2 like" ], "uniprotkb": [ "Guanylate-binding protein 6" ] }, "gene": { "refseq": [ "Gbp6", "AI595338", "Mpa2l" ], "uniprotkb": [ "Gbp6", "AI595338", "Mpa2l" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3", "id": "A0A0G2JDV3", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Guanylate-binding protein 6." }, "publication": [ { "title": "Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27480124", "journal": "BMC immunology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919317.2", "id": "NP_919317.2", "database": "RefSeq" } ], "authors": "Liu X, Jiao Y, Cao Y, Deng N, Ma Y, Hasty KA, Kang A, Chen H, Stuart JM, Gu W", "date": "2016", "pmid": "27480124" }, { "title": "Impact of lactobacilli on orally acquired listeriosis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23012479", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919317.2", "id": "NP_919317.2", "database": "RefSeq" } ], "authors": "Archambaud C, Nahori MA, Soubigou G, Becavin C, Laval L, Lechat P, Smokvina T, Langella P, Lecuit M, Cossart P", "date": "2012", "pmid": "23012479" }, { "title": "A family of IFN-gamma-inducible 65-kD GTPases protects against bacterial infection.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21551061", "journal": "Science (New York, N.Y.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919317.2", "id": "NP_919317.2", "database": "RefSeq" } ], "authors": "Kim BH, Shenoy AR, Kumar P, Das R, Tiwari S, MacMicking JD", "date": "2011", "pmid": "21551061" }, { "title": "An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19158679", "journal": "Nature immunology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919317.2", "id": "NP_919317.2", "database": "RefSeq" } ], "authors": "Burckstummer T, Baumann C, Bluml S, Dixit E, Durnberger G, Jahn H, Planyavsky M, Bilban M, Colinge J, Bennett KL, Superti-Furga G", "date": "2009", "pmid": "19158679" }, { "title": "Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18025219", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919317.2", "id": "NP_919317.2", "database": "RefSeq" } ], "authors": "Degrandi D, Konermann C, Beuter-Gunia C, Kresse A, Wurthner J, Kurig S, Beer S, Pfeffer K", "date": "2007", "pmid": "18025219" }, { "title": "Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12466305", "journal": "Genome research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919317.2", "id": "NP_919317.2", "database": "RefSeq" } ], "authors": "VanBuren V, Piao Y, Dudekula DB, Qian Y, Carter MG, Martin PR, Stagg CA, Bassey UC, Aiba K, Hamatani T, Kargul GJ, Luo AG, Kelso J, Hide W, Ko MS", "date": "2002", "pmid": "12466305" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3#A0A0G2JDV3-1", "isoform_ac": "A0A0G2JDV3-1", "locus": { "end_pos": 105273105, "start_pos": 105291020, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000196520", "id": "ENSMUST00000196520", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000142518", "id": "ENSMUSP00000142518", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JDV3-1|A0A0G2JDV3_MOUSE Isoform 1 of Guanylate-binding protein 6 OS=Mus musculus OX=10090 GN=Gbp6 PE=1 SV=1 CANONICAL=A0A0G2JDV3-1", "length": 611, "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFIYNSMITINHQALEQLHYVTELTELIRAKSSPNPAGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDDYLENALKLIPGDKPRMQASNSCRECIRLFFPNRKCFVFDRPTHDKELLQKLDSITEDQLDPKFQEVTKAFVSYIFTYAKIKTLKEGIKVTGNRLGILVTTYVNAINSGAVPCLDDAVTTLAQRENSVAVQKAADHYSEQMAQRLRLPTETLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELIGENKELFLSKNEEASNKYCQEELDRLSKDFMENISTFFVPCGHKLYMDKREKIEHDYWQVPRKGVKASEVFQSFLQSQAFIESSILQADTALTAGEKAIAEERAQKVAAEKEQELLRQKQKEQQEYMEAQEKSHKENLEQLRRKLEQEREQDIKDHDMMLKKLMKDQKAFLEEGFKKKAEEMNKEIQQLRDVIKDKKRNTDRIKEALLNGFSTVLFHYLVRYLKHL" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3#A0A0G2JF24-1", "isoform_ac": "A0A0G2JF24-1", "locus": { "end_pos": 105280563, "start_pos": 105291020, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000200045", "id": "ENSMUST00000200045", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000142994", "id": "ENSMUSP00000142994", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JF24-1|A0A0G2JDV3_MOUSE Computationally mapped isoform of Guanylate-binding protein 6 OS=Mus musculus OX=10090 GN=Gbp6 PE=1 SV=1 CANONICAL=A0A0G2JDV3-1", "length": 62, "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHG" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:100702", "resource": "KEGG Pathway", "id": "mmu:100702", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919317.2", "annotation": "Findings show that at least 4 IFN-gamma-inducible Gbps--Gbp1, Gbp6, Gbp7, and Gbp10--conferred cell-autonomous immunity to listerial or mycobacterial infection within macrophages and gene-deficient animals", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919317.2", "id": "NP_919317.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q000W5-1", "protein_name": "Guanylate-binding protein 10.", "sequence": { "length": 611, "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGWSRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFIYNSMITINHQALEQLHYVTELTELIRAKSSPNPAGIKNSTEFVSFFPDFVWIVRDFMLELKLNGEDITSDDYLENALKLIPGDKPRMQASNSCRECIRLFFPNRKCFVFDRPTHDKELLQKLDSITEDQLDPKFQEVTKAFVSYIFTYAKIKTLKEGIKVTGNKLGILVTTYVDAINSGAVPCLDDAVTTLAQRENSVAVQKAADHYSEQMAQRLRLPTETLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELIGENKELFLSKNEEASNKYCQEELDRLSKDFMENISTFFVPCGHKLYMDKREKIEHDYWQVPRKGVKASEVFQSFLQSQAFIESSILQADTALTAGKKAIAEERAQKVAAEKEQDLLRQKQKEQQEYMEAQEKSHKENIEQLRRKLMQEREQLIKDHNMMLKKQLKDQKAFLEEGFKKKAEEMNKEIQQLRDVIKDKKRNTDRIKDALLNGFSTVLFHYLVRYLKHL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/128731", "id": "128731", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "A4UUI3-1", "protein_name": "Guanylate-binding protein 4; Guanylate binding protein 4.1.", "sequence": { "length": 631, "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGWSHTGKSYLMNCLAGQNHVSGTLPTSQRFPSGLHRAVSDQGHLDVVHAPPHQARALVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFVYNSMNTINHQALEQLHYVTELTELIRAKSSPNPHGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDEYLENALKLIPGNNPRIQASNSARECIRRFFPNRKCFVFEWPTHDIELIKQLETISEDQLDPTFKESAMAFASYIFTYAKIKTLREGIKVTGNGLGTLVTTYVDAINSGAVPCLDDAVTTLAQRENSVAVQKAASHYSEQMAQRLSLPTDTIQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELLREKNGLFLLKNEEASDKYCQEELDRLSKDLMDNISTFSVPGGHRLYMDMREKIEHDYWQVPRKGVKASEVFQNFLQSQAIIESSILQADTALTAGQKAIAEKHTKKEAAEKEQDLLRQKQKEHQEYMEAQEKRNKENLEQLRRKLEQEREQLIKDHNMMLEKLTKEQKTFREEGYKTQAEELRREIHQLGHNIKEMKQNGDSLVESILRSWFSFISPPSESEKAISSVLSLLRKKDRL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/128731", "id": "128731", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q6ZN66-1", "protein_name": "Guanylate-binding protein 6; GTP-binding protein 6; GBP-6; Guanine nucleotide-binding protein 6.", "sequence": { "length": 633, "sequence": "MESGPKMLAPVCLVENNNEQLLVNQQAIQILEKISQPVVVVAIVGLYRTGKSYLMNHLAGQNHGFPLGSTVQSETKGIWMWCVPHPSKPNHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLCSTFVYNSMSTINHQALEQLHYVTELTELIKAKSSPRPDGVEDSTEFVSFFPDFLWTVRDFTLELKLNGHPITEDEYLENALKLIQGNNPRVQTSNFPRECIRRFFPKRKCFVFDRPTNDKDLLANIEKVSEKQLDPKFQEQTNIFCSYIFTHARTKTLREGITVTGNRLGTLAVTYVEAINSGAVPCLENAVITLAQRENSAAVQRAADYYSQQMAQRVKLPTDTLQELLDMHAACEREAIAIFMEHSFKDENQEFQKKFMETTMNKKGDFLLQNEESSVQYCQAKLNELSKGLMESISAGSFSVPGGHKLYMETKERIEQDYWQVPRKGVKAKEVFQRFLESQMVIEESILQSDKALTDREKAVAVDRAKKEAAEKEQELLKQKLQEQQQQMEAQDKSRKENIAQLKEKLQMEREHLLREQIMMLEHTQKVQNDWLHEGFKKKYEEMNAEISQFKRMIDTTKNDDTPWIARTLDNLADELTAILSAPAKLIGHGVKGVSSLFKKHKLPF" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/128731", "id": "128731", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q8BTS3-1", "protein_name": "Guanylate-binding protein 9; MCG142489, isoform CRA_a.", "sequence": { "length": 619, "sequence": "MTQPQMAPICLVENHNEQLLVNQEAIEILEKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKSNPKNDSWIFALSVLLSSTFVYNSMSTINHQALEQLHYVTELTELIRSKSSRNPHGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDEYLENALKLIPGYNPRVQASNSARECIRCFFPNRKCFVFDRPTHDRELLQKLETISEDQLDLKFREGTKAFVSYVFTYAKIKTLREGIKVTGNRLGTLVTTYVDAINSGAVPCLDDAMTSVARRENSVAVQKAADHYSEQMAQRLRLPTDTLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVEIISEKIAFFWLKNEEASNKYCQEELDRLSKDFMDNISTFSVPGGHRIYTDMRKKIERDYWQVPRKGVKACEVFQNFLQSQYIIESSILQADRALTAGEKAIAEERAQKEVAEKEQELLRQKQKEQQEYMEAQEKRNKENLEQLRRKLMQEREQDIKDHDMMLEKQLKDQKAFLEEGFTNKAEEINAEIERLEHNIKDKKENIGPILELIEKAFCAGVFSSLIMVALLTHNPSLLRK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/128731", "id": "128731", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919317.2", "ac": "NP_919317.2", "name": "guanylate binding protein 6; macrophage activation 2 like.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3", "id": "A0A0G2JDV3", "database": "UniProtKB" } ], "name": "GTPase activity", "id": "GO:0003924" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3", "id": "A0A0G2JDV3", "database": "UniProtKB" } ], "name": "GTP binding", "id": "GO:0005525" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3", "id": "A0A0G2JDV3", "database": "UniProtKB" } ], "name": "cytoplasmic vesicle", "id": "GO:0031410" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3", "id": "A0A0G2JDV3", "database": "UniProtKB" } ], "name": "cytoplasmic vesicle", "id": "GO:0031410" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020005", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3", "id": "A0A0G2JDV3", "database": "UniProtKB" } ], "name": "symbiont-containing vacuole membrane", "id": "GO:0020005" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044406", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3", "id": "A0A0G2JDV3", "database": "UniProtKB" } ], "name": "adhesion of symbiont to host", "id": "GO:0044406" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050830", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3", "id": "A0A0G2JDV3", "database": "UniProtKB" } ], "name": "defense response to Gram-positive bacterium", "id": "GO:0050830" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009617", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3", "id": "A0A0G2JDV3", "database": "UniProtKB" } ], "name": "response to bacterium", "id": "GO:0009617" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071222", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3", "id": "A0A0G2JDV3", "database": "UniProtKB" } ], "name": "cellular response to lipopolysaccharide", "id": "GO:0071222" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071346", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3", "id": "A0A0G2JDV3", "database": "UniProtKB" } ], "name": "cellular response to interferon-gamma", "id": "GO:0071346" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035458", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3", "id": "A0A0G2JDV3", "database": "UniProtKB" } ], "name": "cellular response to interferon-beta", "id": "GO:0035458" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042832", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3", "id": "A0A0G2JDV3", "database": "UniProtKB" } ], "name": "defense response to protozoan", "id": "GO:0042832" } ], "total": 7, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 165, "annotation": "n_glycosylation_sequon", "start_pos": 163 }, { "end_pos": 420, "annotation": "n_glycosylation_sequon", "start_pos": 418 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919317.2", "id": "NP_919317.2", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:100702", "id": "mmu:100702", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/THARIKT/", "id": "THARIKT", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16269", "id": "cd16269", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "id": "IPR027417", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003191", "id": "IPR003191", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015894", "id": "IPR015894", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR030386", "id": "IPR030386", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036543", "id": "IPR036543", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037684", "id": "IPR037684", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF02263", "id": "PF02263", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF02841", "id": "PF02841", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/100702", "id": "100702", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:2140937", "id": "2140937", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A0A0G2JDV3", "disease": [], "mass": { "monoisotopic_mass": 70452.0, "chemical_mass": 70452.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3", "name": "Gbp6; AI595338; Mpa2l.", "locus": { "end_pos": 105270702, "start_pos": 105293698, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000104713", "id": "ENSMUSG00000104713", "database": "Ensembl Gene" } ] } } ] }