{
    "uniprot_canonical_ac": "A0A0A0MS04-1", 
    "sequence": {
        "header": "tr|A0A0A0MS04-1|A0A0A0MS04_HUMAN Isoform 1 of T cell receptor beta variable 6-7 (non-functional)  OS=Homo sapiens OX=9606 GN=TRBV6-7 PE=4 SV=6 CANONICAL=A0A0A0MS04-1", 
        "length": 114, 
        "sequence": "MSLGLLCCVAFSLLWAGPMNAGVTQTPKFHVLKTGQSMTLLCAQDMNHEYMYRYRQDPGKGLRLIYYSVAAALTDKGEVPNGYNVSRSNTEDFPLKLESAAPSQTSVYFCASSY"
    }, 
    "uniprot_id": "A0A0A0MS04_HUMAN", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [], 
            "uniprotkb": [
                "T cell receptor beta variable 6-7 (non-functional)"
            ]
        }, 
        "gene": {
            "refseq": [], 
            "uniprotkb": [
                "TRBV6-7"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "T cell receptor beta variable 6-7 (non-functional)."
    }, 
    "publication": [], 
    "glycosylation": [], 
    "mutation": [
        {
            "start_pos": 102, 
            "subjects_positive": "16", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.1", 
            "annotation": "Filters passed (2/5): patient freq. (1.1%); patient count (16/1514).", 
            "sequence_org": "P", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "H", 
            "subjects_tested": "1514", 
            "end_pos": 102, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 30, 
            "subjects_positive": "4", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.0", 
            "annotation": "Filters passed (2/5): patient freq. (1.0%); num. of cancers (6).", 
            "sequence_org": "H", 
            "disease": {
                "doid": "1793", 
                "url": "http://disease-ontology.org/term/DOID:1793", 
                "icd10": "", 
                "name": "Pancreatic cancer"
            }, 
            "sequence_mut": "Q", 
            "subjects_tested": "399", 
            "end_pos": 30, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 30, 
            "subjects_positive": "3", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.4", 
            "annotation": "Filters passed (1/5): num. of cancers (7).", 
            "sequence_org": "H", 
            "disease": {
                "doid": "4159", 
                "url": "http://disease-ontology.org/term/DOID:4159", 
                "icd10": "", 
                "name": "Skin cancer"
            }, 
            "sequence_mut": "R", 
            "subjects_tested": "820", 
            "end_pos": 30, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 58, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.5", 
            "annotation": "Filters passed (1/5): patient freq. (1.5%).", 
            "sequence_org": "P", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "T", 
            "subjects_tested": "66", 
            "end_pos": 58, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 30, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (7).", 
            "sequence_org": "H", 
            "disease": {
                "doid": "11934", 
                "url": "http://disease-ontology.org/term/DOID:11934", 
                "icd10": "", 
                "name": "Head and neck cancer"
            }, 
            "sequence_mut": "R", 
            "subjects_tested": "980", 
            "end_pos": 30, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 30, 
            "subjects_positive": "3", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.3", 
            "annotation": "Filters passed (1/5): num. of cancers (6).", 
            "sequence_org": "H", 
            "disease": {
                "doid": "10534", 
                "url": "http://disease-ontology.org/term/DOID:10534", 
                "icd10": "", 
                "name": "Stomach cancer"
            }, 
            "sequence_mut": "Q", 
            "subjects_tested": "1044", 
            "end_pos": 30, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 30, 
            "subjects_positive": "3", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.4", 
            "annotation": "Filters passed (1/5): num. of cancers (6).", 
            "sequence_org": "H", 
            "disease": {
                "doid": "4159", 
                "url": "http://disease-ontology.org/term/DOID:4159", 
                "icd10": "", 
                "name": "Skin cancer"
            }, 
            "sequence_mut": "Q", 
            "subjects_tested": "820", 
            "end_pos": 30, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 55, 
            "subjects_positive": "3", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.5", 
            "annotation": "Filters passed (1/5): num. of cancers (3).", 
            "sequence_org": "R", 
            "disease": {
                "doid": "363", 
                "url": "http://disease-ontology.org/term/DOID:363", 
                "icd10": "", 
                "name": "Uterine cancer"
            }, 
            "sequence_mut": "*", 
            "subjects_tested": "558", 
            "end_pos": 55, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 85, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.1", 
            "annotation": "Filters passed (1/5): patient freq. (1.1%).", 
            "sequence_org": "V", 
            "disease": {
                "doid": "9256", 
                "url": "http://disease-ontology.org/term/DOID:9256", 
                "icd10": "", 
                "name": "Colorectal cancer"
            }, 
            "sequence_mut": "A", 
            "subjects_tested": "94", 
            "end_pos": 85, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 30, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.8", 
            "annotation": "Filters passed (1/5): num. of cancers (7).", 
            "sequence_org": "H", 
            "disease": {
                "doid": "2531", 
                "url": "http://disease-ontology.org/term/DOID:2531", 
                "icd10": "", 
                "name": "Hematologic cancer"
            }, 
            "sequence_mut": "R", 
            "subjects_tested": "125", 
            "end_pos": 30, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 55, 
            "subjects_positive": "4", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.5", 
            "annotation": "Filters passed (1/5): num. of cancers (3).", 
            "sequence_org": "R", 
            "disease": {
                "doid": "4159", 
                "url": "http://disease-ontology.org/term/DOID:4159", 
                "icd10": "", 
                "name": "Skin cancer"
            }, 
            "sequence_mut": "*", 
            "subjects_tested": "820", 
            "end_pos": 55, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 58, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.5", 
            "annotation": "Filters passed (1/5): patient freq. (1.5%).", 
            "sequence_org": "P", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "Q", 
            "subjects_tested": "66", 
            "end_pos": 58, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 30, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.8", 
            "annotation": "Filters passed (1/5): num. of cancers (6).", 
            "sequence_org": "H", 
            "disease": {
                "doid": "2531", 
                "url": "http://disease-ontology.org/term/DOID:2531", 
                "icd10": "", 
                "name": "Hematologic cancer"
            }, 
            "sequence_mut": "Q", 
            "subjects_tested": "125", 
            "end_pos": 30, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 30, 
            "subjects_positive": "2", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.2", 
            "annotation": "Filters passed (1/5): num. of cancers (7).", 
            "sequence_org": "H", 
            "disease": {
                "doid": "10534", 
                "url": "http://disease-ontology.org/term/DOID:10534", 
                "icd10": "", 
                "name": "Stomach cancer"
            }, 
            "sequence_mut": "R", 
            "subjects_tested": "1044", 
            "end_pos": 30, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 30, 
            "subjects_positive": "3", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.3", 
            "annotation": "Filters passed (1/5): num. of cancers (7).", 
            "sequence_org": "H", 
            "disease": {
                "doid": "10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "Prostate cancer"
            }, 
            "sequence_mut": "R", 
            "subjects_tested": "1118", 
            "end_pos": 30, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 30, 
            "subjects_positive": "2", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (7).", 
            "sequence_org": "H", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "R", 
            "subjects_tested": "1514", 
            "end_pos": 30, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 55, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (3).", 
            "sequence_org": "R", 
            "disease": {
                "doid": "263", 
                "url": "http://disease-ontology.org/term/DOID:263", 
                "icd10": "", 
                "name": "Kidney cancer"
            }, 
            "sequence_mut": "*", 
            "subjects_tested": "756", 
            "end_pos": 55, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 30, 
            "subjects_positive": "3", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.3", 
            "annotation": "Filters passed (1/5): num. of cancers (6).", 
            "sequence_org": "H", 
            "disease": {
                "doid": "10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "Prostate cancer"
            }, 
            "sequence_mut": "Q", 
            "subjects_tested": "1118", 
            "end_pos": 30, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 30, 
            "subjects_positive": "2", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.5", 
            "annotation": "Filters passed (1/5): num. of cancers (7).", 
            "sequence_org": "H", 
            "disease": {
                "doid": "1793", 
                "url": "http://disease-ontology.org/term/DOID:1793", 
                "icd10": "", 
                "name": "Pancreatic cancer"
            }, 
            "sequence_mut": "R", 
            "subjects_tested": "399", 
            "end_pos": 30, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 30, 
            "subjects_positive": "2", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS04", 
                    "id": "A0A0A0MS04", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (6).", 
            "sequence_org": "H", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "Q", 
            "subjects_tested": "1514", 
            "end_pos": 30, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0A0MS04#A0A0A0MS04-1", 
            "isoform_ac": "A0A0A0MS04-1", 
            "locus": {
                "end_pos": 142509579, 
                "start_pos": 142510009, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000631511", 
                        "id": "ENST00000631511", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000488335", 
                        "id": "ENSP00000488335", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0A0MS04-1|A0A0A0MS04_HUMAN Isoform 1 of T cell receptor beta variable 6-7 (non-functional)  OS=Homo sapiens OX=9606 GN=TRBV6-7 PE=4 SV=6 CANONICAL=A0A0A0MS04-1", 
                "length": 114, 
                "sequence": "MSLGLLCCVAFSLLWAGPMNAGVTQTPKFHVLKTGQSMTLLCAQDMNHEYMYRYRQDPGKGLRLIYYSVAAALTDKGEVPNGYNVSRSNTEDFPLKLESAAPSQTSVYFCASSY"
            }
        }
    ], 
    "pathway": [], 
    "function": [], 
    "orthologs": [], 
    "refseq": {
        "url": "", 
        "ac": "", 
        "name": "", 
        "summary": ""
    }, 
    "go_annotation": {}, 
    "site_annotation": [
        {
            "end_pos": 86, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 84
        }
    ], 
    "crossref": [
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=12232", 
            "id": "12232", 
            "database": "HGNC"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=TRBV6-7", 
            "id": "TRBV6-7", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000253188", 
            "id": "ENSG00000253188", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/KMEGEAP/", 
            "id": "KMEGEAP", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", 
            "id": "IPR013783", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", 
            "id": "IPR036179", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", 
            "id": "IPR013106", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF07686", 
            "id": "PF07686", 
            "database": "Pfam"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0A0A0MS04", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 12588.0, 
        "chemical_mass": 12588.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0A0MS04", 
            "name": "TRBV6-7.", 
            "locus": {
                "end_pos": 142488295, 
                "start_pos": 142487863, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000253188", 
                        "id": "ENSG00000253188", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}