{ "uniprot_canonical_ac": "A0A096MK92-1", "sequence": { "header": "tr|A0A096MK92-1|A0A096MK92_RAT Isoform 1 of Intraflagellar transport 88 OS=Rattus norvegicus OX=10116 GN=Ift88 PE=4 SV=1 CANONICAL=A0A096MK92-1", "length": 825, "sequence": "MMENVHLAPETDEDDLYSGFNDYNPAYDTEELENDTGFQQAVRTSHGRRPPVTAKIPSTAVSRPIATGYGSKTSLTSSMGRPMTGTIQDGVARPMTAVRAAGFSKAALRGSAFDPLGQSRGPAPPLEAKNEDSPEEKIRQLEKKVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQREQVTSPENINLDLTYSVLFNLASQYSANEMYAEALNTYQVIVKNKMFSNAGRLKVNMGNIYLKQRNYSKAIKFYRMALDQIPSVHKEMRIKIMQNIGITFIKTGQYSDAINSFEHIMSMAPSLKAGFNLILSCFAIGDREKMKKAFQKLIAVPLEIDEDDKYISPSDDPHTNLLIEAIKNDHLRQMERERKAMAEKYIMTAAKLIAPVIEASFAVGYNWCVEVVKASQYVELANDLEINKAITYLRQKDFNQAVDTLKMFEKKDSRVKSAAATNLSFLYYLENEFAQASSYADLAVSSDRYNPSALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYKKLNRLDEALDSFLKLHAILRNSAQVLCQIANVYELMEDPNQAIEWLMQLISVVPTDSQALSKLGELYDSEGDKSQAFQYYYESYRYFPSNIEVIEWLGAYYIDTQFCEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKEIHRKFPENVECLRFLVRLCTDIGLKEVQEYATKLKRLEKMKEMREQRIKSGRDSGGGSRSKREGSAGSDSGQNSSASSKSERLSAKLRALPGTDEPYESSGNKEIDASYVDPLGPQIERPKTAARKRIDEDDFADEELGDDLLPE" }, "uniprot_id": "A0A096MK92_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "intraflagellar transport protein 88 homolog isoform X1" ], "uniprotkb": [ "Intraflagellar transport 88" ] }, "gene": { "refseq": [ "Ift88", "Ttc10" ], "uniprotkb": [ "Ift88", "Ttc10" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MK92", "id": "A0A096MK92", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Intraflagellar transport 88." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A096MK92#A0A096MJ06-1", "isoform_ac": "A0A096MJ06-1", "locus": { "end_pos": 37714808, "start_pos": 37744061, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076839", "id": "ENSRNOT00000076839", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000067945", "id": "ENSRNOP00000067945", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MJ06-1|A0A096MK92_RAT Computationally mapped isoform of Intraflagellar transport 88 OS=Rattus norvegicus OX=10116 GN=Ift88 PE=4 SV=1 CANONICAL=A0A096MK92-1", "length": 175, "sequence": "XFSNAGRLKVNMGNIYLKQRNYSKAIKFYRMALDQIPSVHKEMRIKIMQNIGITFIKTGQYSDAINSFEHIMSMAPSLKAGFNLILSCFAIGDREKMKKAFQKLIAVPLEIDEDDKYISPSDDPHTNLLIEAIKNDHLRQMERERKAMAEKYIMTAAKLIAPVIEASFAVGYNWL" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MK92#A0A096MJE9-1", "isoform_ac": "A0A096MJE9-1", "locus": { "end_pos": 37697756, "start_pos": 37708777, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076741", "id": "ENSRNOT00000076741", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068104", "id": "ENSRNOP00000068104", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MJE9-1|A0A096MK92_RAT Computationally mapped isoform of Intraflagellar transport 88 OS=Rattus norvegicus OX=10116 GN=Ift88 PE=4 SV=1 CANONICAL=A0A096MK92-1", "length": 110, "sequence": "MMENVHLAPETDEDDLYSGFNDYNPAYDTEELENDTGFQQAVRTSHGRRPPSKTSLTSSMGRPMTGTIQDGVARPMTAVRAAGFSKAALRGSAFDPLGQSRGPAPPLEAK" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MK92#A0A096MK92-1", "isoform_ac": "A0A096MK92-1", "locus": { "end_pos": 37697756, "start_pos": 37784404, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076608", "id": "ENSRNOT00000076608", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068425", "id": "ENSRNOP00000068425", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MK92-1|A0A096MK92_RAT Isoform 1 of Intraflagellar transport 88 OS=Rattus norvegicus OX=10116 GN=Ift88 PE=4 SV=1 CANONICAL=A0A096MK92-1", "length": 825, "sequence": "MMENVHLAPETDEDDLYSGFNDYNPAYDTEELENDTGFQQAVRTSHGRRPPVTAKIPSTAVSRPIATGYGSKTSLTSSMGRPMTGTIQDGVARPMTAVRAAGFSKAALRGSAFDPLGQSRGPAPPLEAKNEDSPEEKIRQLEKKVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQREQVTSPENINLDLTYSVLFNLASQYSANEMYAEALNTYQVIVKNKMFSNAGRLKVNMGNIYLKQRNYSKAIKFYRMALDQIPSVHKEMRIKIMQNIGITFIKTGQYSDAINSFEHIMSMAPSLKAGFNLILSCFAIGDREKMKKAFQKLIAVPLEIDEDDKYISPSDDPHTNLLIEAIKNDHLRQMERERKAMAEKYIMTAAKLIAPVIEASFAVGYNWCVEVVKASQYVELANDLEINKAITYLRQKDFNQAVDTLKMFEKKDSRVKSAAATNLSFLYYLENEFAQASSYADLAVSSDRYNPSALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYKKLNRLDEALDSFLKLHAILRNSAQVLCQIANVYELMEDPNQAIEWLMQLISVVPTDSQALSKLGELYDSEGDKSQAFQYYYESYRYFPSNIEVIEWLGAYYIDTQFCEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKEIHRKFPENVECLRFLVRLCTDIGLKEVQEYATKLKRLEKMKEMREQRIKSGRDSGGGSRSKREGSAGSDSGQNSSASSKSERLSAKLRALPGTDEPYESSGNKEIDASYVDPLGPQIERPKTAARKRIDEDDFADEELGDDLLPE" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MK92#D4ACI9-1", "isoform_ac": "D4ACI9-1", "locus": { "end_pos": 37697756, "start_pos": 37784370, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000012988", "id": "ENSRNOT00000012988", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000012988", "id": "ENSRNOP00000012988", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D4ACI9-1|A0A096MK92_RAT Computationally mapped isoform of Intraflagellar transport 88 OS=Rattus norvegicus OX=10116 GN=Ift88 PE=4 SV=1 CANONICAL=A0A096MK92-1", "length": 815, "sequence": "MMENVHLAPETDEDDLYSGFNDYNPAYDTEELENDTGFQQAVRTSHGRRPPVTAKIPSTAVSRPIATGYGSKTSLTSSMGRPMTGTIQDGVARPMTAVRAAGFSKAALRGSAFDPLGQSRGPAPPLEAKNEDSPEEKIRQLEKKVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQREQVTSPENINLDLTYSVLFNLASQYSANEMYAEALNTYQVIVKNKMFSNAGRLKVNMGNIYLKQRNYSKAIKFYRMALDQIPSVHKEMRIKIMQNIGITFIKTGQYSDAINSFEHIMSMAPSLKAGFNLILSCFAIGDREKMKKAFQKLIAVPLEIDEDDKYISPSDDPHTNLLIEAIKNDHLRQMERERKAMAEKYIMTAAKLIAPVIEASFAVGYNWCVEVVKASQYVELANDLEINKAITYLRQKDFNQAVDTLKMFEKKDSRVKSAAATNLSFLYYLENEFAQASSYADLAVSSDRYNPSALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYKKLNRLDEALDSFLKLHAILRNSAQVLCQIANVYELMEDPNQAIEWLMQLISVVPTDSQALSKLGELYDSEGDKSQAFQYYYESYRYFPSNIEVIEWLGAYYIDTQFCEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKEIHRKFPENVECLRFLVRLCTDIGLKEVQEYATKLKRLEKMKEMREQRIKSGRDSGGGSRSKREGSAGSDSGQNSSASSKSERLSAKLRALPGTDEPYESSGNKEIGKCLLCGSTGPSDRKTKNCSQKENRRGRFC" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9613829", "resource": "Reactome", "id": "R-RNO-9613829", "name": "Chaperone Mediated Autophagy" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9615710", "resource": "Reactome", "id": "R-RNO-9615710", "name": "Microautophagy" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5610787", "resource": "Reactome", "id": "R-RNO-5610787", "name": "Hedgehog 'off' state" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5620924", "resource": "Reactome", "id": "R-RNO-5620924", "name": "Intraflagellar transport" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q13099-1", "protein_name": "Intraflagellar transport protein 88 homolog; Tetratricopeptide repeat protein 10; TPR repeat protein 10; Recessive polycystic kidney disease protein Tg737 homolog.", "sequence": { "length": 833, "sequence": "MKFTNTKVQMMQNVHLAPETDEDDLYSGYNDYNPIYDIEELENDAAFQQAVRTSHGRRPPITAKISSTAVTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGSAFDPLSQSRGPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQREQVTTPENINLDLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEINKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMKEIREQRIKSGRDGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPGTNEPYESSSNKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/4761", "id": "4761", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A096MK92/", "id": "A0A096MK92", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q61371-1", "protein_name": "Intraflagellar transport protein 88 homolog; Tetratricopeptide repeat protein 10; TPR repeat protein 10; Recessive polycystic kidney disease protein Tg737; TgN(Imorpk)737Rpw.", "sequence": { "length": 824, "sequence": "MENVHLAPETDEDDLYSGFNDYNPAYDTEELENDTGFQQAVRTSHGRRPPVTAKIPSTAVSRPIATGYGSKTSLTSSMGRPMTGTIQDGVARPMTAVRAAGFSKAALRGSAFDPLGQSRGPAPPLEAKNEDSPEEKIRQLEKKVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQREQVTSPENINLDLTYSVLFNLASQYSANEMYAEALNTYQVIVKNKMFSNAGRLKVNMGNIYLKQRNYSKAIKFYRMALDQIPSVHKEMRIKIMQNIGITFIKTGQYSDAINSFEHIMSMAPSLKAGFNLILSCFAIGDREKMKKAFQKLIAVPLEIDEDDKYISPSDDPHTNLLIEAIKNDHLRQMERERKAMAEKYIMTAAKLIAPVIEASFAVGYNWCVEVVKASQYVELANDLEINKAITYLRQKDFNQAVDTLKMFEKKDSRVKSAAATNLSFLYYLENEFAQASSYADLAVNSDRYNPSALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYKKLNRLDEALDSFLKLHAILRNSAQVLCQIANIYELMEDPNQAIEWLMQLISVVPTDSQALSKLGELYDSEGDKSQAFQYYYESYRYFPSNIEVIEWLGAYYIDTQFCEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKEIHRKFPENVECLRFLVRLCTDIGLKEVQEYATKLKRLEKMKEMREQRIKSGRDSSGGSRSKREGSAGSDSGQNNSASSKSERLSAKLRALPGTDEPYESSGNKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/4761", "id": "4761", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006252128.1", "ac": "XP_006252128.1", "name": "intraflagellar transport protein 88 homolog isoform X1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019894", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MK92", "id": "A0A096MK92", "database": "UniProtKB" } ], "name": "kinesin binding", "id": "GO:0019894" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MK92", "id": "A0A096MK92", "database": "UniProtKB" } ], "name": "centriole", "id": "GO:0005814" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097730", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MK92", "id": "A0A096MK92", "database": "UniProtKB" } ], "name": "non-motile cilium", "id": "GO:0097730" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MK92", "id": "A0A096MK92", "database": "UniProtKB" } ], "name": "ciliary basal body", "id": "GO:0036064" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097546", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MK92", "id": "A0A096MK92", "database": "UniProtKB" } ], "name": "ciliary base", "id": "GO:0097546" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MK92", "id": "A0A096MK92", "database": "UniProtKB" } ], "name": "centrosome", "id": "GO:0005813" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001822", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MK92", "id": "A0A096MK92", "database": "UniProtKB" } ], "name": "kidney development", "id": "GO:0001822" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905515", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MK92", "id": "A0A096MK92", "database": "UniProtKB" } ], "name": "non-motile cilium assembly", "id": "GO:1905515" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042073", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MK92", "id": "A0A096MK92", "database": "UniProtKB" } ], "name": "intraciliary transport", "id": "GO:0042073" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060122", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MK92", "id": "A0A096MK92", "database": "UniProtKB" } ], "name": "inner ear receptor cell stereocilium organization", "id": "GO:0060122" } ], "total": 4, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 36, "annotation": "n_glycosylation_sequon", "start_pos": 34 }, { "end_pos": 250, "annotation": "n_glycosylation_sequon", "start_pos": 248 }, { "end_pos": 458, "annotation": "n_glycosylation_sequon", "start_pos": 456 }, { "end_pos": 516, "annotation": "n_glycosylation_sequon", "start_pos": 514 }, { "end_pos": 755, "annotation": "n_glycosylation_sequon", "start_pos": 753 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006252128.1", "id": "XP_006252128.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9613829", "id": "R-RNO-9613829", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9615710", "id": "R-RNO-9615710", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5610787", "id": "R-RNO-5610787", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5620924", "id": "R-RNO-5620924", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000009278", "id": "ENSRNOG00000009278", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/TKNKMFP/", "id": "TKNKMFP", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "id": "IPR011990", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013026", "id": "IPR013026", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "id": "IPR019734", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF13174", "id": "PF13174", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF13181", "id": "PF13181", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/305918", "id": "305918", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309717", "id": "1309717", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A096MK92", "disease": [], "mass": { "monoisotopic_mass": 93055.0, "chemical_mass": 93055.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A096MK92", "name": "Ift88; Ttc10.", "locus": { "end_pos": 37784924, "start_pos": 37691345, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000009278", "id": "ENSRNOG00000009278", "database": "Ensembl Gene" } ] } } ] }