{
    "uniprot_canonical_ac": "A0A096MK47-1", 
    "sequence": {
        "header": "sp|A0A096MK47-1|MLIP_RAT Isoform 1 of Muscular LMNA-interacting protein  OS=Rattus norvegicus OX=10116 GN=Mlip PE=1 SV=1 CANONICAL=A0A096MK47-1", 
        "length": 807, 
        "sequence": "MEFEKHEQGNALKKNEKLEERVTFEYSDHMTFSCESKEERDQRILDYPSEVSGKNSQRKEFNTKEPQGMQKGDLFKAEYVFIVDSDGEDEATCRQGEQGPPGATGNIATRPKSLAISSSLASDVVRPKVRGVDVKVSSHPEIPHGIAPQQKHGQLTSPTTSEQLAHKPPAFSFVSPTNQKTPPVPAKVSGTTVLEEFHIRRLDVHGASEEETATYFHTTAHDSPLPAWKGASTLVFSPSAQLPGSSLCGSNVADHTRGLAPEAQKKVSTSSALNPREDVRTSPSPASGASLRSPSASYIPVRIVMHSLSPSPKPLTSSSHGSLSTVCSQTSSSGNLSKSGLKSPVPSRLSLLTAILKSNPSHQRPLSPASCPTFSLNSLASSTLTLDQKIKQTPSTPKKSLSSCSLTTGSTEQEQASAESHQPCHLSFFSKTTPLSQAQPPSPPALASSSYAATDTEKIPGSTLRSSTTPPQSQTDLFSLADVPSVTPGLSPLSSSKGRKDGDLRAPEKNRNICTRPSTLSFIPPINESTALSSSGKCFHPSPALSDLIDRSKRTCSQRHSDQRPNPSALPTPPVSRAGSASHPHLGYSILPPESSLTQALQRSPSALHPSCGSATCPSRTGMPDSTASNRSSRVSTPSLPVSLTRTKELISPCALSMSAGPENKKPKQYKTKSSYKAFAAIPTNTLLLEQKALDEPARTESNSKASVSDLPVEHSSDSPSRPSQTMLGSETIKTPTTHPRAAGRETKYANLSSSSSTTSESQLTKPGVIRPVPIKSKLFLKKEEEVYEPNPFSKYLEDSSGLFSEQ"
    }, 
    "uniprot_id": "MLIP_RAT", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [], 
            "uniprotkb": [
                "Muscular LMNA-interacting protein", 
                "Cardiac Isl1-interacting protein", 
                "CIP"
            ]
        }, 
        "gene": {
            "refseq": [], 
            "uniprotkb": [
                "Mlip", 
                "Cip"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A096MK47", 
                    "id": "A0A096MK47", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "Muscular LMNA-interacting protein; Cardiac Isl1-interacting protein; CIP."
    }, 
    "publication": [
        {
            "title": "Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/26436652", 
            "journal": "J. Clin. Invest.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A096MK47/publications", 
                    "id": "A0A096MK47", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Chen J., Ding J., Hu X., Liu J., Kataoka M., Seidman C.E., Seidman J.G., Lin Z., Wu G., Ma L., Zeng C., Pu W.T., Zhou B., Deng Z.L., Huang Z.P., Kyselovic J., Nie M., Wakimoto H., Wang D.Z.", 
            "date": "2015", 
            "pmid": "26436652"
        }, 
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", 
            "journal": "Nat. Commun.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A096MK47/publications", 
                    "id": "A0A096MK47", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", 
            "date": "2012", 
            "pmid": "22673903"
        }, 
        {
            "title": "CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/22343712", 
            "journal": "Circ. Res.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A096MK47/publications", 
                    "id": "A0A096MK47", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Chen J., Pu W.T., Chen J.F., Zhou B., Tao Y., Huang Z.P., Wang D.Z., Young Seok H.", 
            "date": "2012", 
            "pmid": "22343712"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A096MK47#A0A096MK47-1", 
            "isoform_ac": "A0A096MK47-1", 
            "locus": {
                "end_pos": 84434784, 
                "start_pos": 84632719, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000076942", 
                        "id": "ENSRNOT00000076942", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000068377", 
                        "id": "ENSRNOP00000068377", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A0A096MK47-1|MLIP_RAT Isoform 1 of Muscular LMNA-interacting protein  OS=Rattus norvegicus OX=10116 GN=Mlip PE=1 SV=1 CANONICAL=A0A096MK47-1", 
                "length": 807, 
                "sequence": "MEFEKHEQGNALKKNEKLEERVTFEYSDHMTFSCESKEERDQRILDYPSEVSGKNSQRKEFNTKEPQGMQKGDLFKAEYVFIVDSDGEDEATCRQGEQGPPGATGNIATRPKSLAISSSLASDVVRPKVRGVDVKVSSHPEIPHGIAPQQKHGQLTSPTTSEQLAHKPPAFSFVSPTNQKTPPVPAKVSGTTVLEEFHIRRLDVHGASEEETATYFHTTAHDSPLPAWKGASTLVFSPSAQLPGSSLCGSNVADHTRGLAPEAQKKVSTSSALNPREDVRTSPSPASGASLRSPSASYIPVRIVMHSLSPSPKPLTSSSHGSLSTVCSQTSSSGNLSKSGLKSPVPSRLSLLTAILKSNPSHQRPLSPASCPTFSLNSLASSTLTLDQKIKQTPSTPKKSLSSCSLTTGSTEQEQASAESHQPCHLSFFSKTTPLSQAQPPSPPALASSSYAATDTEKIPGSTLRSSTTPPQSQTDLFSLADVPSVTPGLSPLSSSKGRKDGDLRAPEKNRNICTRPSTLSFIPPINESTALSSSGKCFHPSPALSDLIDRSKRTCSQRHSDQRPNPSALPTPPVSRAGSASHPHLGYSILPPESSLTQALQRSPSALHPSCGSATCPSRTGMPDSTASNRSSRVSTPSLPVSLTRTKELISPCALSMSAGPENKKPKQYKTKSSYKAFAAIPTNTLLLEQKALDEPARTESNSKASVSDLPVEHSSDSPSRPSQTMLGSETIKTPTTHPRAAGRETKYANLSSSSSTTSESQLTKPGVIRPVPIKSKLFLKKEEEVYEPNPFSKYLEDSSGLFSEQ"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A096MK47#A0A096MJS3-1", 
            "isoform_ac": "A0A096MJS3-1", 
            "locus": {
                "end_pos": 84434784, 
                "start_pos": 84522550, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000076213", 
                        "id": "ENSRNOT00000076213", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000068241", 
                        "id": "ENSRNOP00000068241", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A096MJS3-1|MLIP_RAT Computationally mapped isoform of Muscular LMNA-interacting protein  OS=Rattus norvegicus OX=10116 GN=Mlip PE=1 SV=1 CANONICAL=A0A096MK47-1", 
                "length": 774, 
                "sequence": "MTSCVLAGSIETTPKFEYSDHMTFSCESKEERDQRILDYPSEVSGKNSQRKEFNTKEPQGMQKGDLFKAEYVFIVDSDGEDEATCRQGEQGPPGATGNIATRPKSLAISSSLASDVVRPKVRGVDVKVSSHPEIPHGIAPQQKHGQKTPPVPAKVSGTTVLEEFHIRRLDVHGASEEETATYFHTTAHDSPLPAWKGASTLVFSPSAQLPGSSLCGSNVADHTRGLAPEAQKKVSTSSALNPREDVRTSPSPASGASLRSPSASYIPVRIVMHSLSPSPKPLTSSSHGSLSTVCSQTSSSGNLSKSGLKSPVPSRLSLLTAILKSNPSHQRPLSPASCPTFSLNSLASSTLTLDQKIKQTPSTPKKSLSSCSLTTGSTEQEQASAESHQPCHLSFFSKTTPLSQAQPPSPPALASSSYAATDTEKIPGSTLRSSTTPPQSQTDLFSLADVPSVTPGLSPLSSSKGRKDGDLRAPEKNRNICTRPSTLSFIPPINESTALSSSGKCFHPSPALSDLIDRSKRTCSQRHSDQRPNPSALPTPPVSRAGSASHPHLGYSILPPESSLTQALQRSPSALHPSCGSATCPSRTGMPDSTASNRSSRVSTPSLPVSLTRTKELISPCALSMSAGPENKKPKQYKTKSSYKAFAAIPTNTLLLEQKALDEPARTESNSKASVSDLPVEHSSDSPSRPSQTMLGSETIKTPTTHPRAAGRETKYANLSSSSSTTSESQLTKPGVIRPVPIKSKLFLKKEEEVYEPNPFSKYLEDSSGLFSEQ"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A096MK47#A0A096MK47-2", 
            "isoform_ac": "A0A096MK47-2", 
            "locus": {
                "end_pos": 0, 
                "start_pos": 0, 
                "chromosome": "", 
                "evidence": []
            }, 
            "sequence": {
                "header": "sp|A0A096MK47-2|MLIP_RAT Isoform 2 of Muscular LMNA-interacting protein  OS=Rattus norvegicus OX=10116 GN=Mlip PE=1 SV=1 CANONICAL=A0A096MK47-1", 
                "length": 782, 
                "sequence": "MEFEKHEQGNALKKNEKLEERVTFEYSDHMTFSCESKEERDQRILDYPSEVSGKNSQRKEFNTKEPQGMQKGDLFKAEYVFIVDSDGEDEATCRQGEQGPPGATGNIATRPKSLAISSSLASDVVRPKVRGVDVKVSSHPEIPHGIAPQQKHGQKTPPVPAKVSGTTVLEEFHIRRLDVHGASEEETATYFHTTAHDSPLPAWKGASTLVFSPSAQLPGSSLCGSNVADHTRGLAPEAQKKVSTSSALNPREDVRTSPSPASGASLRSPSASYIPVRIVMHSLSPSPKPLTSSSHGSLSTVCSQTSSSGNLSKSGLKSPVPSRLSLLTAILKSNPSHQRPLSPASCPTFSLNSLASSTLTLDQKIKQTPSTPKKSLSSCSLTTGSTEQEQASAESHQPCHLSFFSKTTPLSQAQPPSPPALASSSYAATDTEKIPGSTLRSSTTPPQSQTDLFSLADVPSVTPGLSPLSSSKGRKDGDLRAPEKNRNICTRPSTLSFIPPINESTALSSSGKCFHPSPALSDLIDRSKRTCSQRHSDQRPNPSALPTPPVSRAGSASHPHLGYSILPPESSLTQALQRSPSALHPSCGSATCPSRTGMPDSTASNRSSRVSTPSLPVSLTRTKELISPCALSMSAGPENKKPKQYKTKSSYKAFAAIPTNTLLLEQKALDEPARTESNSKASVSDLPVEHSSDSPSRPSQTMLGSETIKTPTTHPRAAGRETKYANLSSSSSTTSESQLTKPGVIRPVPIKSKLFLKKEEEVYEPNPFSKYLEDSSGLFSEQ"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A096MK47#A0A096MK47-3", 
            "isoform_ac": "A0A096MK47-3", 
            "locus": {
                "end_pos": 0, 
                "start_pos": 0, 
                "chromosome": "", 
                "evidence": []
            }, 
            "sequence": {
                "header": "sp|A0A096MK47-3|MLIP_RAT Isoform 3 of Muscular LMNA-interacting protein  OS=Rattus norvegicus OX=10116 GN=Mlip PE=1 SV=1 CANONICAL=A0A096MK47-1", 
                "length": 269, 
                "sequence": "MEFEKHEQGNALKKNEKLEERVTFEYSDHMTFSCESKEERDQRILDYPSEVSGKNSQRKEFNTKEPQGMQKGDLFKAEYVFIVDSDGEDEATCRQGEQGPPGATGNIATRPKSLAISSSLASDVVRPKVRGVDVKVSSHPEIPHGIAPQQKHGQALDEPARTESNSKASVSDLPVEHSSDSPSRPSQTMLGSETIKTPTTHPRAAGRETKYANLSSSSSTTSESQLTKPGVIRPVPIKSKLFLKKEEEVYEPNPFSKYLEDSSGLFSEQ"
            }
        }
    ], 
    "pathway": [], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A096MK47#function", 
            "annotation": "Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy (PubMed:22343712, PubMed:26436652). Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A096MK47#function", 
                    "id": "A0A096MK47", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "refseq": {
        "url": "", 
        "ac": "", 
        "name": "", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MK47", 
                                "id": "A0A096MK47", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "transcription corepressor activity", 
                        "id": "GO:0003714"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005521", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MK47", 
                                "id": "A0A096MK47", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "lamin binding", 
                        "id": "GO:0005521"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MK47", 
                                "id": "A0A096MK47", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nuclear envelope", 
                        "id": "GO:0005635"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MK47", 
                                "id": "A0A096MK47", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "sarcolemma", 
                        "id": "GO:0042383"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016605", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MK47", 
                                "id": "A0A096MK47", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "PML body", 
                        "id": "GO:0016605"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MK47", 
                                "id": "A0A096MK47", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }
                ], 
                "total": 4, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MK47", 
                                "id": "A0A096MK47", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of transcription by RNA polymerase II", 
                        "id": "GO:0000122"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MK47", 
                                "id": "A0A096MK47", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of transcription by RNA polymerase II", 
                        "id": "GO:0045944"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010614", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MK47", 
                                "id": "A0A096MK47", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of cardiac muscle hypertrophy", 
                        "id": "GO:0010614"
                    }
                ], 
                "total": 3, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 337, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 335
        }, 
        {
            "end_pos": 529, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 527
        }, 
        {
            "end_pos": 632, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 630
        }, 
        {
            "end_pos": 753, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 751
        }
    ], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000005934", 
            "id": "ENSRNOG00000005934", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/FQMTSCI/", 
            "id": "FQMTSCI", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029331", 
            "id": "IPR029331", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF15274", 
            "id": "PF15274", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31514", 
            "id": "PTHR31514", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0A096MK47", 
            "id": "PR_A0A096MK47", 
            "database": "PRO"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1590513", 
            "id": "1590513", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0A096MK47", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 86186.0, 
        "chemical_mass": 86186.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A096MK47", 
            "name": "Mlip; Cip.", 
            "locus": {
                "end_pos": 84434784, 
                "start_pos": 84632817, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000005934", 
                        "id": "ENSRNOG00000005934", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}