{ "uniprot_canonical_ac": "A0A096MJZ2-1", "sequence": { "header": "tr|A0A096MJZ2-1|A0A096MJZ2_RAT Isoform 1 of Transducin (beta)-like 2 OS=Rattus norvegicus OX=10116 GN=Tbl2 PE=1 SV=1 CANONICAL=A0A096MJZ2-1", "length": 442, "sequence": "MELPQMPELMGLSLLVGLLALVATAAVARGWLRAEEKPSQPICQKENESKKSVSKKQKQNQRIRKEKPQQHNFTHPLLAAALKSHSGNISCMDFSSNGKYLATCADDRTVRIWSTKDFLQREHRSMRANVELDHATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGFTFTATPEDFPKKHKAPIINIGIADTGKFIMTASSDTTVLIWNLKGQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVCFGKKGEFQEVLRAFELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKQQDPYLLRTGRFEEASTMPCRLALSPDTHVLALATGTSIHLFNTRRGEKEEYFECVHGECIADLTFDITGRFLASCGDRAVRLFHNTPGHRAVVEEMQGLLKRASSESTRQRLQQQLTQAQEALKSLGALKK" }, "uniprot_id": "A0A096MJZ2_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "transducin beta-like protein 2" ], "uniprotkb": [ "Transducin (beta)-like 2", "RCG21429, isoform CRA_b" ] }, "gene": { "refseq": [ "Tbl2" ], "uniprotkb": [ "Tbl2", "rCG_21429" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJZ2", "id": "A0A096MJZ2", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Transducin (beta)-like 2; RCG21429, isoform CRA_b." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJZ2#A0A096MJZ2-1", "isoform_ac": "A0A096MJZ2-1", "locus": { "end_pos": 24568738, "start_pos": 24578734, "chromosome": "12", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076209", "id": "ENSRNOT00000076209", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068316", "id": "ENSRNOP00000068316", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MJZ2-1|A0A096MJZ2_RAT Isoform 1 of Transducin (beta)-like 2 OS=Rattus norvegicus OX=10116 GN=Tbl2 PE=1 SV=1 CANONICAL=A0A096MJZ2-1", "length": 442, "sequence": "MELPQMPELMGLSLLVGLLALVATAAVARGWLRAEEKPSQPICQKENESKKSVSKKQKQNQRIRKEKPQQHNFTHPLLAAALKSHSGNISCMDFSSNGKYLATCADDRTVRIWSTKDFLQREHRSMRANVELDHATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGFTFTATPEDFPKKHKAPIINIGIADTGKFIMTASSDTTVLIWNLKGQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVCFGKKGEFQEVLRAFELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKQQDPYLLRTGRFEEASTMPCRLALSPDTHVLALATGTSIHLFNTRRGEKEEYFECVHGECIADLTFDITGRFLASCGDRAVRLFHNTPGHRAVVEEMQGLLKRASSESTRQRLQQQLTQAQEALKSLGALKK" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJZ2#M0RCS2-1", "isoform_ac": "M0RCS2-1", "locus": { "end_pos": 24571578, "start_pos": 24578734, "chromosome": "12", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000075138", "id": "ENSRNOT00000075138", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000067401", "id": "ENSRNOP00000067401", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|M0RCS2-1|A0A096MJZ2_RAT Computationally mapped isoform of Transducin (beta)-like 2 OS=Rattus norvegicus OX=10116 GN=Tbl2 PE=1 SV=2 CANONICAL=A0A096MJZ2-1", "length": 153, "sequence": "MELPQMPELMGLSLLVGLLALVATAAVARGWLRAEEKPSQPICQKENESKKSVSKKQKQNQRIRKEKPQQHNFTHPLLAAALKSHSGNISCMDFSSNGKYLATCADDRTVRIWSTKDFLQREHRSMRANVELDHATLVRFSPDCREIHHDCLQ" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:686610", "resource": "KEGG Pathway", "id": "rno:686610", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q9Y4P3-1", "protein_name": "Transducin beta-like protein 2; WS beta-transducin repeats protein; WS-betaTRP; Williams-Beuren syndrome chromosomal region 13 protein.", "sequence": { "length": 447, "sequence": "MELSQMSELMGLSVLLGLLALMATAAVARGWLRAGEERSGRPACQKANGFPPDKSSGSKKQKQYQRIRKEKPQQHNFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMTASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALASGSSIHLYNTRRGEKEECFERVHGECIANLSFDITGRFLASCGDRAVRLFHNTPGHRAMVEEMQGHLKRASNESTRQRLQQQLTQAQETLKSLGALKK" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A096MJZ2/", "id": "A0A096MJZ2", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/8260", "id": "8260", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q9R099-1", "protein_name": "Transducin beta-like protein 2.", "sequence": { "length": 442, "sequence": "MELPQMPELMGLSLLVGLLALVATAAVARGWLRAEEKPSQPVCQKENEPKKSGSKKQKQNQRVRKEKPQQHSFTHPLLAAALKSHSGNISCMDFSSNGKYLATCADDRTVRIWSTKDFLQREHRSMRANVELDHATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGFTFTATPEDFPKKHKAPIINIGIADTGKFIMTASSDTTVLIWNLKGQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVCFGKKGEFQEVLRAFELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKQQDPYLLRTGRFEEASTMPCRLALSPDTHVLALATGTNIHLFNTRRGEKEEYFECVHGECIADLTFDITGRFLASCGDRAVRLFHNTPGHRAVVEEMQSLLKRASSESTRQRLQQQLTQAQEALKSLGALKK" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A096MJZ2/", "id": "A0A096MJZ2", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/8260", "id": "8260", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001071365.1", "ac": "XP_001071365.1", "name": "transducin beta-like protein 2.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJZ2", "id": "A0A096MJZ2", "database": "UniProtKB" } ], "name": "protein kinase binding", "id": "GO:0019901" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051219", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJZ2", "id": "A0A096MJZ2", "database": "UniProtKB" } ], "name": "phosphoprotein binding", "id": "GO:0051219" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031369", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJZ2", "id": "A0A096MJZ2", "database": "UniProtKB" } ], "name": "translation initiation factor binding", "id": "GO:0031369" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJZ2", "id": "A0A096MJZ2", "database": "UniProtKB" } ], "name": "endoplasmic reticulum", "id": "GO:0005783" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071456", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJZ2", "id": "A0A096MJZ2", "database": "UniProtKB" } ], "name": "cellular response to hypoxia", "id": "GO:0071456" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042149", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJZ2", "id": "A0A096MJZ2", "database": "UniProtKB" } ], "name": "cellular response to glucose starvation", "id": "GO:0042149" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030968", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJZ2", "id": "A0A096MJZ2", "database": "UniProtKB" } ], "name": "endoplasmic reticulum unfolded protein response", "id": "GO:0030968" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 49, "annotation": "n_glycosylation_sequon", "start_pos": 47 }, { "end_pos": 74, "annotation": "n_glycosylation_sequon", "start_pos": 72 }, { "end_pos": 90, "annotation": "n_glycosylation_sequon", "start_pos": 88 }, { "end_pos": 229, "annotation": "n_glycosylation_sequon", "start_pos": 227 }, { "end_pos": 287, "annotation": "n_glycosylation_sequon", "start_pos": 285 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001071365.1", "id": "XP_001071365.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:686610", "id": "rno:686610", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000046252", "id": "ENSRNOG00000046252", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/DREHKCL/", "id": "DREHKCL", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "id": "IPR001680", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "id": "IPR015943", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017986", "id": "IPR017986", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "id": "IPR019775", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "id": "IPR020472", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "id": "IPR036322", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR042410", "id": "IPR042410", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00400", "id": "PF00400", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44321", "id": "PTHR44321", "database": "PANTHER" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/686610", "id": "686610", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1595038", "id": "1595038", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A096MJZ2", "disease": [], "mass": { "monoisotopic_mass": 49614.0, "chemical_mass": 49614.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJZ2", "name": "Tbl2; rCG_21429.", "locus": { "end_pos": 24565849, "start_pos": 24578786, "chromosome": "12", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000046252", "id": "ENSRNOG00000046252", "database": "Ensembl Gene" } ] } } ] }