{ "uniprot_canonical_ac": "A0A096MJY4-1", "sequence": { "header": "sp|A0A096MJY4-1|MEF2C_RAT Isoform 1 of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 473, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" }, "uniprot_id": "MEF2C_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "myocyte-specific enhancer factor 2C isoform X1" ], "uniprotkb": [ "Myocyte-specific enhancer factor 2C", "Myocyte enhancer factor 2C" ] }, "gene": { "refseq": [ "Mef2c" ], "uniprotkb": [ "Mef2c" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Myocyte-specific enhancer factor 2C; Myocyte enhancer factor 2C." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4/publications", "id": "A0A096MJY4", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" }, { "title": "MEF2C DNA-binding activity is inhibited through its interaction with the regulatory protein Ki-1/57.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15862299", "journal": "FEBS Lett.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4/publications", "id": "A0A096MJY4", "database": "UniProtKB" } ], "authors": "Kobarg J., Crosara-Alberto D.P., Franchini K.G., Kobarg C.B., Theizen T.H.", "date": "2005", "pmid": "15862299" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#A0A096MJY4-1", "isoform_ac": "A0A096MJY4-1", "locus": { "end_pos": 11730033, "start_pos": 11818305, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076710", "id": "ENSRNOT00000076710", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068307", "id": "ENSRNOP00000068307", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0A096MJY4-1|MEF2C_RAT Isoform 1 of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 473, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#A0A096MJ09-1", "isoform_ac": "A0A096MJ09-1", "locus": { "end_pos": 11730033, "start_pos": 11818305, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076992", "id": "ENSRNOT00000076992", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000067948", "id": "ENSRNOP00000067948", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MJ09-1|MEF2C_RAT Computationally mapped isoform of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 431, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEALNKKENKGSESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIPAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#A0A096MJ23-1", "isoform_ac": "A0A096MJ23-1", "locus": { "end_pos": 11730033, "start_pos": 11818305, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076481", "id": "ENSRNOT00000076481", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000067963", "id": "ENSRNOP00000067963", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MJ23-1|MEF2C_RAT Computationally mapped isoform of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 441, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#A0A096MJD9-1", "isoform_ac": "A0A096MJD9-1", "locus": { "end_pos": 11730033, "start_pos": 11818305, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000075931", "id": "ENSRNOT00000075931", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000067970", "id": "ENSRNOP00000067970", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MJD9-1|MEF2C_RAT Computationally mapped isoform of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 471, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEALNKKENKGSESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIPAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#A0A096MJZ6-1", "isoform_ac": "A0A096MJZ6-1", "locus": { "end_pos": 11730033, "start_pos": 11818305, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076416", "id": "ENSRNOT00000076416", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068323", "id": "ENSRNOP00000068323", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MJZ6-1|MEF2C_RAT Computationally mapped isoform of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 393, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#A0A096MK01-1", "isoform_ac": "A0A096MK01-1", "locus": { "end_pos": 11730033, "start_pos": 11818305, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076408", "id": "ENSRNOT00000076408", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068328", "id": "ENSRNOP00000068328", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MK01-1|MEF2C_RAT Computationally mapped isoform of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 417, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#A0A096MK43-1", "isoform_ac": "A0A096MK43-1", "locus": { "end_pos": 11730033, "start_pos": 11818305, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076239", "id": "ENSRNOT00000076239", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068373", "id": "ENSRNOP00000068373", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MK43-1|MEF2C_RAT Computationally mapped isoform of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 463, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEALNKKENKGSESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIPAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#A0A096MK88-1", "isoform_ac": "A0A096MK88-1", "locus": { "end_pos": 11730033, "start_pos": 11818305, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076084", "id": "ENSRNOT00000076084", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068421", "id": "ENSRNOP00000068421", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MK88-1|MEF2C_RAT Computationally mapped isoform of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 465, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#A0A096MKI4-1", "isoform_ac": "A0A096MKI4-1", "locus": { "end_pos": 11730033, "start_pos": 11818305, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076230", "id": "ENSRNOT00000076230", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068527", "id": "ENSRNOP00000068527", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MKI4-1|MEF2C_RAT Computationally mapped isoform of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 433, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:499497", "resource": "KEGG Pathway", "id": "rno:499497", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-525793", "resource": "Reactome", "id": "R-RNO-525793", "name": "Myogenesis" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#function", "annotation": "Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes (PubMed:15862299). Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#function", "id": "A0A096MJY4", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q8CFN5-1", "protein_name": "Myocyte-specific enhancer factor 2C; Myocyte enhancer factor 2C.", "sequence": { "length": 474, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPSFEMPVTIPVSSHNSLVYSNPVSTLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLSIKSEPVSPPRDRTTTPSRYPQHTTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A096MJY4/", "id": "A0A096MJY4", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/31087", "id": "31087", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q06413-1", "protein_name": "Myocyte-specific enhancer factor 2C; Myocyte enhancer factor 2C.", "sequence": { "length": 473, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/31087", "id": "31087", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006224017.1", "ac": "XP_006224017.1", "name": "myocyte-specific enhancer factor 2C isoform X1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "DNA binding", "id": "GO:0003677" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "histone deacetylase binding", "id": "GO:0042826" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008134", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "transcription factor binding", "id": "GO:0008134" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "RNA polymerase II proximal promoter sequence-specific DNA binding", "id": "GO:0000978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "sequence-specific DNA binding", "id": "GO:0043565" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "protein dimerization activity", "id": "GO:0046983" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "RNA polymerase II regulatory region sequence-specific DNA binding", "id": "GO:0000977" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044212", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "transcription regulatory region DNA binding", "id": "GO:0044212" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228" } ], "total": 10, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000790", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": 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