{ "uniprot_canonical_ac": "A0A096MJM7-1", "sequence": { "header": "tr|A0A096MJM7-1|A0A096MJM7_RAT Isoform 1 of Neuralized-like (Drosophila) (Predicted), isoform CRA_b OS=Rattus norvegicus OX=10116 GN=Neurl1 PE=4 SV=1 CANONICAL=A0A096MJM7-1", "length": 574, "sequence": "MGNNFSSVSSLQRGNPSRASRGHPQNLKDSIGSSFPVPSHRCHHKQKHCPPALSGGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFYRINESAAMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLRCEADEARLSVSLCDLNVPGADGEDGAPPAGCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVARLEHGRDERALVFTSRPVRVAETIFIKVTRSGGARPGALSFGVTTCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAPAGMQLCVDASQPLWMLFSLHGAITQVRILGSTIMAERGGPSLPCSPASTPTSPSALGSRLSDPLLSTCGSGPLGGSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGHMCLCYSCGLRLKKALHACCPICRRPIKDIIKTYRSS" }, "uniprot_id": "A0A096MJM7_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "E3 ubiquitin-protein ligase NEURL1 isoform X1" ], "uniprotkb": [ "Neuralized-like (Drosophila) (Predicted), isoform CRA_b", "Neuralized E3 ubiquitin protein ligase 1" ] }, "gene": { "refseq": [ "Neurl1", "Neurl", "Neurl1a" ], "uniprotkb": [ "Neurl1", "Neurl_predicted", "rCG_57691", "Neurl", "Neurl1a" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Neuralized-like (Drosophila) (Predicted), isoform CRA_b; Neuralized E3 ubiquitin protein ligase 1." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7#A0A096MJM7-1", "isoform_ac": "A0A096MJM7-1", "locus": { "end_pos": 266953209, "start_pos": 267037133, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076452", "id": "ENSRNOT00000076452", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068189", "id": "ENSRNOP00000068189", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MJM7-1|A0A096MJM7_RAT Isoform 1 of Neuralized-like (Drosophila) (Predicted), isoform CRA_b OS=Rattus norvegicus OX=10116 GN=Neurl1 PE=4 SV=1 CANONICAL=A0A096MJM7-1", "length": 574, "sequence": "MGNNFSSVSSLQRGNPSRASRGHPQNLKDSIGSSFPVPSHRCHHKQKHCPPALSGGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFYRINESAAMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLRCEADEARLSVSLCDLNVPGADGEDGAPPAGCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVARLEHGRDERALVFTSRPVRVAETIFIKVTRSGGARPGALSFGVTTCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAPAGMQLCVDASQPLWMLFSLHGAITQVRILGSTIMAERGGPSLPCSPASTPTSPSALGSRLSDPLLSTCGSGPLGGSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGHMCLCYSCGLRLKKALHACCPICRRPIKDIIKTYRSS" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJM7#D3ZZE6-1", "isoform_ac": "D3ZZE6-1", "locus": { "end_pos": 266953209, "start_pos": 267020443, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000054696", "id": "ENSRNOT00000054696", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000051580", "id": "ENSRNOP00000051580", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZZE6-1|A0A096MJM7_RAT Computationally mapped isoform of Neuralized-like (Drosophila) (Predicted), isoform CRA_b OS=Rattus norvegicus OX=10116 GN=Neurl1 PE=4 SV=1 CANONICAL=A0A096MJM7-1", "length": 240, "sequence": "MGNNFSSVSSLQRGNPSRASRGHPQNLKDSIGSSFPVPSHRCHHKQKHCPPALSGGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFYRINESAAMLFFSGVRTADPLWALVDVYGLTRGVQLLGTQTLHTGRASSSLSFLIWKMGHG" } } ], "pathway": [], "function": [], "orthologs": [ { "uniprot_canonical_ac": "O76050-1", "protein_name": "E3 ubiquitin-protein ligase NEURL1; 2.3.2.27; Neuralized-like protein 1A; h-neu; h-neuralized 1; RING-type E3 ubiquitin transferase NEURL1; RING finger protein 67.", "sequence": { "length": 574, "sequence": "MGNNFSSIPSLPRGNPSRAPRGHPQNLKDSIGGPFPVTSHRCHHKQKHCPAVLPSGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFHRINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLRREADDARLSVSLCDLNVPGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVARVEHGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVTTCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAAGMQLCVDASQPLWMLFGLHGTITQIRILGSTILAERGIPSLPCSPASTPTSPSALGSRLSDPLLSTCSSGPLGSSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGHMCLCYACGLRLKKALHACCPICRRPIKDIIKTYRSS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/32503", "id": "32503", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A096MJM7/", "id": "A0A096MJM7", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q923S6-1", "protein_name": "E3 ubiquitin-protein ligase NEURL1; 2.3.2.27; Neuralized-like protein 1A; m-neu1; m-neuralized 1; RING-type E3 ubiquitin transferase NEURL1; Neuralized1.", "sequence": { "length": 574, "sequence": "MGNNFSSVSSLQRGNPSRASRGHPQNLKDSIGGSFPVPSHRCHHKQKHCPPTLSGGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFYRINESAAMLFFSGVRTVDPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLRCEADEARLSVSLCDLNVPGADGDDGAPPAGCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVARLEHGRDERALVFTSRPVRVAETIFIKVTRSGGGRAGALSFGVTTCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAAGMQLCVDASQPLWMLFSLHGAITQVRILGSTIMTERGGPSLPCSPASTPTSPSALGIRLSDPLLSTCGSGPLGGSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGHMCLCYSCGLRLKKALHACCPICRRPIKDIIKTYRSS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/32503", "id": "32503", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A096MJM7/", "id": "A0A096MJM7", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006231572.1", "ac": "XP_006231572.1", "name": "E3 ubiquitin-protein ligase NEURL1 isoform X1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "ubiquitin protein ligase activity", "id": "GO:0061630" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045183", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "translation factor activity, non-nucleic acid binding", "id": "GO:0045183" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "postsynaptic density", "id": "GO:0014069" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043197", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "dendritic spine", "id": "GO:0043197" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043204", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "perikaryon", "id": "GO:0043204" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097440", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "apical dendrite", "id": "GO:0097440" } ], "total": 6, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "nervous system development", "id": "GO:0007399" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "brain development", "id": "GO:0007420" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045746", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "negative regulation of Notch signaling pathway", "id": "GO:0045746" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007519", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "skeletal muscle tissue development", "id": "GO:0007519" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "negative regulation of cell population proliferation", "id": "GO:0008285" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "positive regulation of apoptotic process", "id": "GO:0043065" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045741", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "positive regulation of epidermal growth factor-activated receptor activity", "id": "GO:0045741" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007595", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "lactation", "id": "GO:0007595" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090129", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "positive regulation of synapse maturation", "id": "GO:0090129" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051491", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "positive regulation of filopodium assembly", "id": "GO:0051491" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060999", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "positive regulation of dendritic spine development", "id": "GO:0060999" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071230", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "cellular response to amino acid stimulus", "id": "GO:0071230" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048170", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "positive regulation of long-term neuronal synaptic plasticity", "id": "GO:0048170" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007288", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "sperm axoneme assembly", "id": "GO:0007288" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006513", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "id": "A0A096MJM7", "database": "UniProtKB" } ], "name": "protein monoubiquitination", "id": "GO:0006513" } ], "total": 15, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 6, "annotation": "n_glycosylation_sequon", "start_pos": 4 }, { "end_pos": 185, "annotation": "n_glycosylation_sequon", "start_pos": 183 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006231572.1", "id": "XP_006231572.1", "database": "RefSeq" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020339", "id": "ENSRNOG00000020339", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/ANGSRMI/", "id": "ANGSRMI", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "id": "IPR001841", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "id": "IPR013083", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037962", "id": "IPR037962", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006573", "id": "IPR006573", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF07177", "id": "PF07177", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12429", "id": "PTHR12429", "database": "PANTHER" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/309459", "id": "309459", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307021", "id": "1307021", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A096MJM7", "disease": [], "mass": { "monoisotopic_mass": 61774.0, "chemical_mass": 61774.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJM7", "name": "Neurl1; Neurl_predicted; rCG_57691; Neurl; Neurl1a.", "locus": { "end_pos": 267038883, "start_pos": 266952561, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000020339", "id": "ENSRNOG00000020339", "database": "Ensembl Gene" } ] } } ] }