{ "uniprot_canonical_ac": "A0A096MJE4-1", "sequence": { "header": "tr|A0A096MJE4-1|A0A096MJE4_RAT Isoform 1 of Cytotoxic T-lymphocyte-associated protein 4, isoform CRA_a OS=Rattus norvegicus OX=10116 GN=Ctla4 PE=4 SV=1 CANONICAL=A0A096MJE4-1", "length": 223, "sequence": "MARLGVQRYKTHLQLPSRTWPFGVLLSLLFIPIFSEAIQVTQPSVVLASSHGVASFPCEYASSHNTDEVRVTVLRQTNDQVTEVCATTFTVKNTLGFLDDPFCSGTFNESRVNLTIQGLRAADTGLYFCKVELMYPPPYFVGMGNGTQIYVIDPEPCPDSDFLLWILAAVSSGLFFYSFLVTAVSLNRTLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN" }, "uniprot_id": "A0A096MJE4_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [], "uniprotkb": [ "Cytotoxic T-lymphocyte-associated protein 4, isoform CRA_a", "Cytotoxic T-lymphocyte-associated protein 4" ] }, "gene": { "refseq": [], "uniprotkb": [ "Ctla4", "rCG_22161" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJE4", "id": "A0A096MJE4", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Cytotoxic T-lymphocyte-associated protein 4, isoform CRA_a; Cytotoxic T-lymphocyte-associated protein 4." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJE4#A0A096MJE4-1", "isoform_ac": "A0A096MJE4-1", "locus": { "end_pos": 67699515, "start_pos": 67704987, "chromosome": "9", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000091237", "id": "ENSRNOT00000091237", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000073071", "id": "ENSRNOP00000073071", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MJE4-1|A0A096MJE4_RAT Isoform 1 of Cytotoxic T-lymphocyte-associated protein 4, isoform CRA_a OS=Rattus norvegicus OX=10116 GN=Ctla4 PE=4 SV=1 CANONICAL=A0A096MJE4-1", "length": 223, "sequence": "MARLGVQRYKTHLQLPSRTWPFGVLLSLLFIPIFSEAIQVTQPSVVLASSHGVASFPCEYASSHNTDEVRVTVLRQTNDQVTEVCATTFTVKNTLGFLDDPFCSGTFNESRVNLTIQGLRAADTGLYFCKVELMYPPPYFVGMGNGTQIYVIDPEPCPDSDFLLWILAAVSSGLFFYSFLVTAVSLNRTLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJE4#G3V7D2-1", "isoform_ac": "G3V7D2-1", "locus": { "end_pos": 67699515, "start_pos": 67704950, "chromosome": "9", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000088183", "id": "ENSRNOT00000088183", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000069885", "id": "ENSRNOP00000069885", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|G3V7D2-1|A0A096MJE4_RAT Computationally mapped isoform of Cytotoxic T-lymphocyte-associated protein 4, isoform CRA_a OS=Rattus norvegicus OX=10116 GN=Ctla4 PE=4 SV=2 CANONICAL=A0A096MJE4-1", "length": 174, "sequence": "MARLGVQRYKTHLQLPSRTWPFGVLLSLLFIPIFSEAIQVTQPSVVLASSHGVASFPCEYASSHNTDEVRVTVLRQTNDQVTEVCATTFTVKNTLGFLDDPFCSGTFNESRVNLTIQGLRAADTGLYFCKVELMYPPPYFVGMGNGTQIYVIAKEKKSSYNRGLCENAPNRARM" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-389513", "resource": "Reactome", "id": "R-RNO-389513", "name": "CTLA4 inhibitory signaling" } ], "function": [], "orthologs": [], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJE4", "id": "A0A096MJE4", "database": "UniProtKB" } ], "name": "signaling receptor activity", "id": "GO:0038023" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJE4", "id": "A0A096MJE4", "database": "UniProtKB" } ], "name": "external side of 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"id": "GO:0006955" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJE4", "id": "A0A096MJE4", "database": "UniProtKB" } ], "name": "positive regulation of apoptotic process", "id": "GO:0043065" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJE4", "id": "A0A096MJE4", "database": "UniProtKB" } ], "name": "cellular response to DNA damage stimulus", "id": "GO:0006974" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030889", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJE4", "id": "A0A096MJE4", "database": "UniProtKB" } ], "name": "negative regulation of B cell proliferation", "id": "GO:0030889" } ], "total": 10, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 110, "annotation": "n_glycosylation_sequon", "start_pos": 108 }, { "end_pos": 115, "annotation": "n_glycosylation_sequon", "start_pos": 113 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