{ "uniprot_canonical_ac": "A0A096MJE3-1", "sequence": { "header": "tr|A0A096MJE3-1|A0A096MJE3_RAT Isoform 1 of G1 to S phase transition 2 OS=Rattus norvegicus OX=10116 GN=Gspt2 PE=4 SV=1 CANONICAL=A0A096MJE3-1", "length": 632, "sequence": "MDLGSSSDSAPDCWDQVDMEAPGSAPSGDEIAPAATAAAEAAEAEAQRRHLSLAFSSQLNINAKPFVPSVSAAEFVPSFLPGSAQLPAPTASSCDETCIGGAAEPQGKRMEWGAPVEPSKDGPLVSWEGSNSAVTMELSEPVVENGEVEMALEESWELKEVSEAAPEGSLGDVGPPEESGKEVMEEKEEIRKSKSVVRPSGAPKKEHVNVVFIGHVDAGKSTIGGQIMFLTGMVDRRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKYLIVLINKMDDPTVDWSSERYEECKEKLVPFLKKVGFSPKKDIHFMPCSGLTGANIKEQSDFCPWYTGLPFIPYLDSLPNFNRSIDGPIRLPIVDKYKDMGTVVLGKLESGSIFKGQQLVMMPNKHSVEVLGIVSDDAETDFVAPGENLKIRLKGIEEEEILPGFILCEPNNLCHSGRTFDVQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALISLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD" }, "uniprot_id": "A0A096MJE3_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "eukaryotic peptide chain release factor GTP-binding subunit ERF3B" ], "uniprotkb": [ "G1 to S phase transition 2", "RCG36424" ] }, "gene": { "refseq": [ "Gspt2", "RGD1563213" ], "uniprotkb": [ "Gspt2", "rCG_36424", "RGD1563213" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJE3", "id": "A0A096MJE3", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "G1 to S phase transition 2; RCG36424." }, "publication": [ { "title": "Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22658674", "journal": "Cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102789.1", "id": "NP_001102789.1", "database": "RefSeq" } ], "authors": "Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW", "date": "2012", "pmid": "22658674" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJE3#A0A096MJE3-1", "isoform_ac": "A0A096MJE3-1", "locus": { "end_pos": 63959537, "start_pos": 63961432, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000071762", "id": "ENSRNOT00000071762", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068098", "id": "ENSRNOP00000068098", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MJE3-1|A0A096MJE3_RAT Isoform 1 of G1 to S phase transition 2 OS=Rattus norvegicus OX=10116 GN=Gspt2 PE=4 SV=1 CANONICAL=A0A096MJE3-1", "length": 632, "sequence": "MDLGSSSDSAPDCWDQVDMEAPGSAPSGDEIAPAATAAAEAAEAEAQRRHLSLAFSSQLNINAKPFVPSVSAAEFVPSFLPGSAQLPAPTASSCDETCIGGAAEPQGKRMEWGAPVEPSKDGPLVSWEGSNSAVTMELSEPVVENGEVEMALEESWELKEVSEAAPEGSLGDVGPPEESGKEVMEEKEEIRKSKSVVRPSGAPKKEHVNVVFIGHVDAGKSTIGGQIMFLTGMVDRRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKYLIVLINKMDDPTVDWSSERYEECKEKLVPFLKKVGFSPKKDIHFMPCSGLTGANIKEQSDFCPWYTGLPFIPYLDSLPNFNRSIDGPIRLPIVDKYKDMGTVVLGKLESGSIFKGQQLVMMPNKHSVEVLGIVSDDAETDFVAPGENLKIRLKGIEEEEILPGFILCEPNNLCHSGRTFDVQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALISLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJE3#A0A096MKF6-1", "isoform_ac": "A0A096MKF6-1", "locus": { "end_pos": 63959370, "start_pos": 63961432, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076205", "id": "ENSRNOT00000076205", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068496", "id": "ENSRNOP00000068496", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MKF6-1|A0A096MJE3_RAT Computationally mapped isoform of G1 to S phase transition 2 OS=Rattus norvegicus OX=10116 GN=Gspt2 PE=4 SV=1 CANONICAL=A0A096MJE3-1", "length": 129, "sequence": "MDLGSSSDSAPDCWDQVDMEAPGSAPSGDEIAPAATAAAEAAEAEAQRRHLSLAFSSQLNINAKPFVPSVSAAEFVPSFLPGSAQLPAPTASSCDETCIGGAAEPQEKFHSENPRFVSFLMLRSQSCHS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:501582", "resource": "KEGG Pathway", "id": "rno:501582", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975956", "resource": "Reactome", "id": "R-RNO-975956", "name": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975957", "resource": "Reactome", "id": "R-RNO-975957", "name": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-72764", "resource": "Reactome", "id": "R-RNO-72764", "name": "Eukaryotic Translation Termination" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q149F3-1", "protein_name": "Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Eukaryotic peptide chain release factor subunit 3b; eRF3b; G1 to S phase transition protein 2 homolog.", "sequence": { "length": 632, "sequence": "MDLGSSSDSAPDCWDQVDMEAPGSAPSGDGIAPAAMAAAEAAEAEAQRKHLSLAFSSQLNIHAKPFVPSVSAAEFVPSFLPGSAQPPAPTASSCDETCIGGAGEPEGKRMEWGAPVEPSKDGPLVSWEGSSSVVTMELSEPVVENGEVEMALEESWELKEVSEAKPEASLGDAGPPEESVKEVMEEKEEVRKSKSVSIPSGAPKKEHVNVVFIGHVDAGKSTIGGQIMFLTGMVDRRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKYLIVLINKMDDPTVDWSSERYEECKEKLVPFLKKVGFSPKKDIHFMPCSGLTGANIKEQSDFCPWYTGLPFIPYLDSLPNFNRSIDGPIRLPIVDKYKDMGTVVLGKLESGSIFKGQQLVMMPNKHSVEVLGIVSDDAETDFVAPGENLKIRLKGIEEEEILPGFILCEPSNLCHSGRTFDVQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALISLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/99786", "id": "99786", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A096MJE3/", "id": "A0A096MJE3", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q8IYD1-1", "protein_name": "Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Eukaryotic peptide chain release factor subunit 3b; eRF3b; G1 to S phase transition protein 2 homolog.", "sequence": { "length": 628, "sequence": "MDSGSSSSDSAPDCWDQVDMESPGSAPSGDGVSSAVAEAQREPLSSAFSRKLNVNAKPFVPNVHAAEFVPSFLRGPTQPPTLPAGSGSNDETCTGAGYPQGKRMGRGAPVEPSREEPLVSLEGSNSAVTMELSEPVVENGEVEMALEESWEHSKEVSEAEPGGGSSGDSGPPEESGQEMMEEKEEIRKSKSVIVPSGAPKKEHVNVVFIGHVDAGKSTIGGQIMFLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETERKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSIERYEECKEKLVPFLKKVGFSPKKDIHFMPCSGLTGANIKEQSDFCPWYTGLPFIPYLDNLPNFNRSIDGPIRLPIVDKYKDMGTVVLGKLESGSIFKGQQLVMMPNKHNVEVLGILSDDTETDFVAPGENLKIRLKGIEEEEILPGFILCDPSNLCHSGRTFDVQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALISLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/99786", "id": "99786", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A096MJE3/", "id": "A0A096MJE3", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102789.1", "ac": "NP_001102789.1", "name": "eukaryotic peptide chain release factor GTP-binding subunit ERF3B.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJE3", "id": "A0A096MJE3", "database": "UniProtKB" } ], "name": "GTPase activity", "id": "GO:0003924" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003747", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJE3", "id": "A0A096MJE3", "database": "UniProtKB" } ], "name": "translation release factor activity", "id": "GO:0003747" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJE3", "id": "A0A096MJE3", "database": "UniProtKB" } ], "name": "GTP binding", "id": "GO:0005525" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018444", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJE3", "id": "A0A096MJE3", "database": "UniProtKB" } ], "name": "translation release factor complex", "id": "GO:0018444" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJE3", "id": "A0A096MJE3", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002184", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJE3", "id": "A0A096MJE3", "database": "UniProtKB" } ], "name": "cytoplasmic translational termination", "id": "GO:0002184" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJE3", "id": "A0A096MJE3", "database": "UniProtKB" } ], "name": "translation", "id": "GO:0006412" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 430, "annotation": "n_glycosylation_sequon", "start_pos": 428 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102789.1", "id": "NP_001102789.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975956", "id": "R-RNO-975956", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975957", "id": "R-RNO-975957", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-72764", "id": "R-RNO-72764", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:501582", "id": "rno:501582", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000048817", "id": "ENSRNOG00000048817", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/RTDIRWH/", "id": "RTDIRWH", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "id": "IPR027417", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009000", "id": "IPR009000", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009818", "id": "IPR009818", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000795", "id": "IPR000795", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR031157", "id": "IPR031157", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR004160", "id": "IPR004160", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR004161", "id": "IPR004161", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009001", "id": "IPR009001", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF07145", "id": "PF07145", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00009", "id": "PF00009", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF03143", "id": "PF03143", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF03144", "id": "PF03144", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/501582", "id": "501582", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1563213", "id": "1563213", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A096MJE3", "disease": [], "mass": { "monoisotopic_mass": 69233.0, "chemical_mass": 69233.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJE3", "name": "Gspt2; rCG_36424; RGD1563213.", "locus": { "end_pos": 63954727, "start_pos": 63961613, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000048817", "id": "ENSRNOG00000048817", "database": "Ensembl Gene" } ] } } ] }