{
    "uniprot_canonical_ac": "A0A096MJ56-1", 
    "sequence": {
        "header": "tr|A0A096MJ56-1|A0A096MJ56_RAT Isoform 1 of Ectodysplasin-A  OS=Rattus norvegicus OX=10116 GN=Eda PE=3 SV=1 CANONICAL=A0A096MJ56-1", 
        "length": 378, 
        "sequence": "MGYPEVERREPLPAAAPRERGSQGCGCRGAPARAGEGNSCRLFLGFFGLSLALHLLTLCCYLELRSELRRERGTESRLGGPGAPGTSGTLSSPGSLDPVGPITRHLGQPSFQQQPLEPGEDPLPPDSQDRHQMALLNFFFPDEKPYSEEESRRVRRNKRSKSGEGADGKKAGPPGPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKTGTRENQPAVVHLQGQGSAIQVKNGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGTYFIYSQVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVKMVHADISINMSKHTTFFGAIRLGEAPAS"
    }, 
    "uniprot_id": "A0A096MJ56_RAT", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [], 
            "uniprotkb": [
                "Ectodysplasin-A"
            ]
        }, 
        "gene": {
            "refseq": [], 
            "uniprotkb": [
                "Eda"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
                    "id": "A0A096MJ56", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "Ectodysplasin-A."
    }, 
    "publication": [], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A096MJ56#A0A096MIW0-1", 
            "isoform_ac": "A0A096MIW0-1", 
            "locus": {
                "end_pos": 69730417, 
                "start_pos": 70219124, 
                "chromosome": "X", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000076425", 
                        "id": "ENSRNOT00000076425", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000067898", 
                        "id": "ENSRNOP00000067898", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A096MIW0-1|A0A096MJ56_RAT Computationally mapped isoform of Ectodysplasin-A  OS=Rattus norvegicus OX=10116 GN=Eda PE=3 SV=1 CANONICAL=A0A096MJ56-1", 
                "length": 377, 
                "sequence": "MGYPEVERREPLPAAAPRERGSQGCGCRGAPARAGEGNSCRLFLGFFGLSLALHLLTLCCYLELRSELRRERGTESRLGGPGAPGTSGTLSSPGSLDPVGPITRHLGQPSFQQQPLEPGEDPLPPDSQDRHQMALLNFFFPDEKPYSEEESRRVRRNKRSKSGEGADGPVKNKKKGKKAGPPGPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKTGTRENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVKMVHADISINMSKHTTFFGAIRLGEAPAS"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A096MJ56#A0A096MJ56-1", 
            "isoform_ac": "A0A096MJ56-1", 
            "locus": {
                "end_pos": 69730417, 
                "start_pos": 70219124, 
                "chromosome": "X", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000075980", 
                        "id": "ENSRNOT00000075980", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000067997", 
                        "id": "ENSRNOP00000067997", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A096MJ56-1|A0A096MJ56_RAT Isoform 1 of Ectodysplasin-A  OS=Rattus norvegicus OX=10116 GN=Eda PE=3 SV=1 CANONICAL=A0A096MJ56-1", 
                "length": 378, 
                "sequence": "MGYPEVERREPLPAAAPRERGSQGCGCRGAPARAGEGNSCRLFLGFFGLSLALHLLTLCCYLELRSELRRERGTESRLGGPGAPGTSGTLSSPGSLDPVGPITRHLGQPSFQQQPLEPGEDPLPPDSQDRHQMALLNFFFPDEKPYSEEESRRVRRNKRSKSGEGADGKKAGPPGPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKTGTRENQPAVVHLQGQGSAIQVKNGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGTYFIYSQVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVKMVHADISINMSKHTTFFGAIRLGEAPAS"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5669034", 
            "resource": "Reactome", 
            "id": "R-RNO-5669034", 
            "name": "TNFs bind their physiological receptors"
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q92838-1", 
            "protein_name": "Ectodysplasin-A; Ectodermal dysplasia protein; EDA protein.", 
            "sequence": {
                "length": 391, 
                "sequence": "MGYPEVERRELLPAAAPRERGSQGCGCGGAPARAGEGNSCLLFLGFFGLSLALHLLTLCCYLELRSELRRERGAESRLGGSGTPGTSGTLSSLGGLDPDSPITSHLGQPSPKQQPLEPGEAALHSDSQDGHQMALLNFFFPDEKPYSEEESRRVRRNKRSKSNEGADGPVKNKKKGKKAGPPGPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKAGTRENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGTYFIYSQVEVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVKMVHADISINMSKHTTFFGAIRLGEAPAS"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0A096MJ56/", 
                    "id": "A0A096MJ56", 
                    "database": "OMA"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "refseq": {
        "url": "", 
        "ac": "", 
        "name": "", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005164", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
                                "id": "A0A096MJ56", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "tumor necrosis factor receptor binding", 
                        "id": "GO:0005164"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
                                "id": "A0A096MJ56", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "lipid droplet", 
                        "id": "GO:0005811"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005887", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
                                "id": "A0A096MJ56", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of plasma membrane", 
                        "id": "GO:0005887"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
                                "id": "A0A096MJ56", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "apical part of cell", 
                        "id": "GO:0045177"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
                                "id": "A0A096MJ56", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum membrane", 
                        "id": "GO:0005789"
                    }
                ], 
                "total": 4, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
                                "id": "A0A096MJ56", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "immune response", 
                        "id": "GO:0006955"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
                                "id": "A0A096MJ56", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of gene expression", 
                        "id": "GO:0010628"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051092", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
                                "id": "A0A096MJ56", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of NF-kappaB transcription factor activity", 
                        "id": "GO:0051092"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901224", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
                                "id": "A0A096MJ56", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of NIK/NF-kappaB signaling", 
                        "id": "GO:1901224"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
                                "id": "A0A096MJ56", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cell-matrix adhesion", 
                        "id": "GO:0007160"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
                                "id": "A0A096MJ56", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of I-kappaB kinase/NF-kappaB signaling", 
                        "id": "GO:0043123"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042475", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
                                "id": "A0A096MJ56", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "odontogenesis of dentin-containing tooth", 
                        "id": "GO:0042475"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060789", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
                                "id": "A0A096MJ56", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "hair follicle placode formation", 
                        "id": "GO:0060789"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
                                "id": "A0A096MJ56", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of canonical Wnt signaling pathway", 
                        "id": "GO:0090263"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043473", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
                                "id": "A0A096MJ56", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "pigmentation", 
                        "id": "GO:0043473"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010467", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
                                "id": "A0A096MJ56", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "gene expression", 
                        "id": "GO:0010467"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060662", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
                                "id": "A0A096MJ56", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "salivary gland cavitation", 
                        "id": "GO:0060662"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061153", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
                                "id": "A0A096MJ56", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "trachea gland development", 
                        "id": "GO:0061153"
                    }
                ], 
                "total": 13, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 302, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 300
        }, 
        {
            "end_pos": 361, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 359
        }
    ], 
    "crossref": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5669034", 
            "id": "R-RNO-5669034", 
            "database": "Reactome"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000032208", 
            "id": "ENSRNOG00000032208", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/SIHHRVF/", 
            "id": "SIHHRVF", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00184", 
            "id": "cd00184", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008983", 
            "id": "IPR008983", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006052", 
            "id": "IPR006052", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00229", 
            "id": "PF00229", 
            "database": "Pfam"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1563178", 
            "id": "1563178", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0A096MJ56", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 40206.0, 
        "chemical_mass": 40206.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A096MJ56", 
            "name": "Eda.", 
            "locus": {
                "end_pos": 70220329, 
                "start_pos": 69730242, 
                "chromosome": "X", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000032208", 
                        "id": "ENSRNOG00000032208", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}