{
    "uniprot_canonical_ac": "A0A087WTH5-1", 
    "sequence": {
        "header": "sp|A0A087WTH5-1|KCE1B_HUMAN Isoform 1 of Potassium voltage-gated channel subfamily E member 1B  OS=Homo sapiens OX=9606 GN=KCNE1B PE=3 SV=2 CANONICAL=A0A087WTH5-1", 
        "length": 132, 
        "sequence": "MPRMILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSGDGKLEALYVLMVLGFFGFFTLGIMLSYIRSKKLEHSNDPFNVYIESNAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNTHLPETKPSP"
    }, 
    "uniprot_id": "KCE1B_HUMAN", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "potassium voltage-gated channel subfamily E member 1B", 
                "potassium channel, voltage gated subfamily E regulatory beta subunit 1B"
            ], 
            "uniprotkb": [
                "Potassium voltage-gated channel subfamily E member 1B"
            ]
        }, 
        "gene": {
            "refseq": [
                "KCNE1B"
            ], 
            "uniprotkb": [
                "KCNE1B"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A087WTH5", 
                    "id": "A0A087WTH5", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Potassium voltage-gated channel subfamily E member 1B."
    }, 
    "publication": [], 
    "glycosylation": [
        {
            "residue": "Asn", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A087WTH5", 
                    "id": "A0A087WTH5", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/", 
                    "id": "", 
                    "database": "PubMed"
                }
            ], 
            "relation": "attached", 
            "position": 29, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }, 
        {
            "residue": "Asn", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A087WTH5", 
                    "id": "A0A087WTH5", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/", 
                    "id": "", 
                    "database": "PubMed"
                }
            ], 
            "relation": "attached", 
            "position": 8, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }
    ], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A087WTH5#A0A087WTH5-1", 
            "isoform_ac": "A0A087WTH5-1", 
            "locus": {
                "end_pos": 7819236, 
                "start_pos": 7819631, 
                "chromosome": "21", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000618699", 
                        "id": "ENST00000618699", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000477875", 
                        "id": "ENSP00000477875", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A0A087WTH5-1|KCE1B_HUMAN Isoform 1 of Potassium voltage-gated channel subfamily E member 1B  OS=Homo sapiens OX=9606 GN=KCNE1B PE=3 SV=2 CANONICAL=A0A087WTH5-1", 
                "length": 132, 
                "sequence": "MPRMILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSGDGKLEALYVLMVLGFFGFFTLGIMLSYIRSKKLEHSNDPFNVYIESNAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNTHLPETKPSP"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A087WTH5#A0A087WU88-1", 
            "isoform_ac": "A0A087WU88-1", 
            "locus": {
                "end_pos": 7819236, 
                "start_pos": 7819622, 
                "chromosome": "21", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000622690", 
                        "id": "ENST00000622690", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000478461", 
                        "id": "ENSP00000478461", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A087WU88-1|KCE1B_HUMAN Computationally mapped isoform of Potassium voltage-gated channel subfamily E member 1B  OS=Homo sapiens OX=9606 GN=KCNE1B PE=3 SV=1 CANONICAL=A0A087WTH5-1", 
                "length": 129, 
                "sequence": "MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSGDGKLEALYVLMVLGFFGFFTLGIMLSYIRSKKLEHSNDPFNVYIESNAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNTHLPETKPSP"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A087WTH5#A0A087WWU3-1", 
            "isoform_ac": "A0A087WWU3-1", 
            "locus": {
                "end_pos": 7819362, 
                "start_pos": 7819631, 
                "chromosome": "21", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000617668", 
                        "id": "ENST00000617668", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000480511", 
                        "id": "ENSP00000480511", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A087WWU3-1|KCE1B_HUMAN Computationally mapped isoform of Potassium voltage-gated channel subfamily E member 1B  OS=Homo sapiens OX=9606 GN=KCNE1B PE=3 SV=1 CANONICAL=A0A087WTH5-1", 
                "length": 90, 
                "sequence": "MPRMILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSGDGKLEALYVLMVLGFFGFFTLGIMLSYIRSKKLEHSNDPFNVYIESNAW"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:102723475", 
            "resource": "KEGG Pathway", 
            "id": "hsa:102723475", 
            "name": ""
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "P15383-1", 
            "protein_name": "Potassium voltage-gated channel subfamily E member 1; Minimal potassium channel; Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink.", 
            "sequence": {
                "length": 130, 
                "sequence": "MALSNSTTVLPFLASLWQETDEPGGNMSADLARRSQLRDDSKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNVYIESDAWQEKGKALFQARVLESFRACYVIENQAAVEQPATHLPELKPLS"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/185", 
                    "id": "185", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "P23299-1", 
            "protein_name": "Potassium voltage-gated channel subfamily E member 1; Delayed rectifier potassium channel subunit IsK; mISK; Minimal potassium channel; IKs producing slow voltage-gated potassium channel subunit beta Mink.", 
            "sequence": {
                "length": 129, 
                "sequence": "MSLPNSTTVLPFLARLWQETAEQGGNVSGLARKSQLRDDSKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNVYIESDAWQEKGKAVFQARVLESFRACYVIENQAAVEQPATHLPELKPLS"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/185", 
                    "id": "185", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001316994.1", 
        "ac": "NP_001316994.1", 
        "name": "potassium voltage-gated channel subfamily E member 1B; potassium channel, voltage gated subfamily E regulatory beta subunit 1B.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015459", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A087WTH5", 
                                "id": "A0A087WTH5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "potassium channel regulator activity", 
                        "id": "GO:0015459"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A087WTH5", 
                                "id": "A0A087WTH5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ion channel binding", 
                        "id": "GO:0044325"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005249", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A087WTH5", 
                                "id": "A0A087WTH5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "voltage-gated potassium channel activity", 
                        "id": "GO:0005249"
                    }
                ], 
                "total": 3, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A087WTH5", 
                                "id": "A0A087WTH5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086011", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A087WTH5", 
                                "id": "A0A087WTH5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "membrane repolarization during action potential", 
                        "id": "GO:0086011"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086091", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A087WTH5", 
                                "id": "A0A087WTH5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of heart rate by cardiac conduction", 
                        "id": "GO:0086091"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060307", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A087WTH5", 
                                "id": "A0A087WTH5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of ventricular cardiac muscle cell membrane repolarization", 
                        "id": "GO:0060307"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086005", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A087WTH5", 
                                "id": "A0A087WTH5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ventricular cardiac muscle cell action potential", 
                        "id": "GO:0086005"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902260", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A087WTH5", 
                                "id": "A0A087WTH5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of delayed rectifier potassium channel activity", 
                        "id": "GO:1902260"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097623", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A087WTH5", 
                                "id": "A0A087WTH5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "potassium ion export across plasma membrane", 
                        "id": "GO:0097623"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098915", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A087WTH5", 
                                "id": "A0A087WTH5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "membrane repolarization during ventricular cardiac muscle cell action potential", 
                        "id": "GO:0098915"
                    }
                ], 
                "total": 7, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 10, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 8
        }, 
        {
            "end_pos": 31, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 29
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001316994.1", 
            "id": "NP_001316994.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=52280", 
            "id": "52280", 
            "database": "HGNC"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A0A087WTH5", 
            "id": "A0A087WTH5", 
            "database": "PHAROS"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A0A087WTH5", 
            "id": "NX_A0A087WTH5", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=KCNE1B", 
            "id": "KCNE1B", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:102723475", 
            "id": "hsa:102723475", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000276289", 
            "id": "ENSG00000276289", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/YIESDIW/", 
            "id": "YIESDIW", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000369", 
            "id": "IPR000369", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR005424", 
            "id": "IPR005424", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF02060", 
            "id": "PF02060", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15282", 
            "id": "PTHR15282", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0A087WTH5", 
            "id": "PR_A0A087WTH5", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/102723475", 
            "id": "102723475", 
            "database": "GeneID"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0A087WTH5", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 15028.0, 
        "chemical_mass": 15028.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A087WTH5", 
            "name": "KCNE1B.", 
            "locus": {
                "end_pos": 7816675, 
                "start_pos": 7829926, 
                "chromosome": "21", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000276289", 
                        "id": "ENSG00000276289", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}