{
    "uniprot_canonical_ac": "A0A075B5X4-1", 
    "sequence": {
        "header": "tr|A0A075B5X4-1|A0A075B5X4_MOUSE Isoform 1 of Immunoglobulin heavy variable V8-11  OS=Mus musculus OX=10090 GN=Ighv8-11 PE=4 SV=2 CANONICAL=A0A075B5X4-1", 
        "length": 119, 
        "sequence": "MGRLTSSFLLLIVPAYVLSQITQKESGPGILQPSQTLSLTCSFSGFSLSTSGMGVGWIHQPSGNGLEWLAHIWWNDNKYYNTALKSRLTISKDTSNNQVFLKIASVDTADTATYYCARI"
    }, 
    "uniprot_id": "A0A075B5X4_MOUSE", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [], 
            "uniprotkb": [
                "Immunoglobulin heavy variable V8-11"
            ]
        }, 
        "gene": {
            "refseq": [], 
            "uniprotkb": [
                "Ighv8-11"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A075B5X4", 
                    "id": "A0A075B5X4", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "recommendedname": {
        "full": "Immunoglobulin heavy variable V8-11."
    }, 
    "publication": [], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A075B5X4#A0A075B5X4-1", 
            "isoform_ac": "A0A075B5X4-1", 
            "locus": {
                "end_pos": 115567150, 
                "start_pos": 115567591, 
                "chromosome": "12", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000103536", 
                        "id": "ENSMUST00000103536", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000100317", 
                        "id": "ENSMUSP00000100317", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A075B5X4-1|A0A075B5X4_MOUSE Isoform 1 of Immunoglobulin heavy variable V8-11  OS=Mus musculus OX=10090 GN=Ighv8-11 PE=4 SV=2 CANONICAL=A0A075B5X4-1", 
                "length": 119, 
                "sequence": "MGRLTSSFLLLIVPAYVLSQITQKESGPGILQPSQTLSLTCSFSGFSLSTSGMGVGWIHQPSGNGLEWLAHIWWNDNKYYNTALKSRLTISKDTSNNQVFLKIASVDTADTATYYCARI"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-173623", 
            "resource": "Reactome", 
            "id": "R-MMU-173623", 
            "name": "Classical antibody-mediated complement activation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-198933", 
            "resource": "Reactome", 
            "id": "R-MMU-198933", 
            "name": "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2029481", 
            "resource": "Reactome", 
            "id": "R-MMU-2029481", 
            "name": "FCGR activation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2168880", 
            "resource": "Reactome", 
            "id": "R-MMU-2168880", 
            "name": "Scavenging of heme from plasma"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-202733", 
            "resource": "Reactome", 
            "id": "R-MMU-202733", 
            "name": "Cell surface interactions at the vascular wall"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2454202", 
            "resource": "Reactome", 
            "id": "R-MMU-2454202", 
            "name": "Fc epsilon receptor (FCERI) signaling"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-977606", 
            "resource": "Reactome", 
            "id": "R-MMU-977606", 
            "name": "Regulation of Complement cascade"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983695", 
            "resource": "Reactome", 
            "id": "R-MMU-983695", 
            "name": "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2029485", 
            "resource": "Reactome", 
            "id": "R-MMU-2029485", 
            "name": "Role of phospholipids in phagocytosis"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2029482", 
            "resource": "Reactome", 
            "id": "R-MMU-2029482", 
            "name": "Regulation of actin dynamics for phagocytic cup formation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2871796", 
            "resource": "Reactome", 
            "id": "R-MMU-2871796", 
            "name": "FCERI mediated MAPK activation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2871809", 
            "resource": "Reactome", 
            "id": "R-MMU-2871809", 
            "name": "FCERI mediated Ca+2 mobilization"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5690714", 
            "resource": "Reactome", 
            "id": "R-MMU-5690714", 
            "name": "CD22 mediated BCR regulation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-166663", 
            "resource": "Reactome", 
            "id": "R-MMU-166663", 
            "name": "Initial triggering of complement"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2871837", 
            "resource": "Reactome", 
            "id": "R-MMU-2871837", 
            "name": "FCERI mediated NF-kB activation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2730905", 
            "resource": "Reactome", 
            "id": "R-MMU-2730905", 
            "name": "Role of LAT2/NTAL/LAB on calcium mobilization"
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "F1LWD1-1", 
            "protein_name": "Ig-like domain-containing protein.", 
            "sequence": {
                "length": 126, 
                "sequence": "QVSLKESGPGILQPFQTLSLTCSFSGFSLGTSNMGVGWIRQTSGKGLEYLATIWWDDDKYFNPSLNSRLTVSKDTSNNQAFLKITSVDTADTGTYYCTQRPHWCCLTFWLYNISGWFSAQFLPILS"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0A075B5X4/", 
                    "id": "A0A075B5X4", 
                    "database": "OMA"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }
    ], 
    "refseq": {
        "url": "", 
        "ac": "", 
        "name": "", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034987", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B5X4", 
                                "id": "A0A075B5X4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "immunoglobulin receptor binding", 
                        "id": "GO:0034987"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003823", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B5X4", 
                                "id": "A0A075B5X4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "antigen binding", 
                        "id": "GO:0003823"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B5X4", 
                                "id": "A0A075B5X4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "external side of plasma membrane", 
                        "id": "GO:0009897"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042571", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B5X4", 
                                "id": "A0A075B5X4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "immunoglobulin complex, circulating", 
                        "id": "GO:0042571"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006911", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B5X4", 
                                "id": "A0A075B5X4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "phagocytosis, engulfment", 
                        "id": "GO:0006911"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B5X4", 
                                "id": "A0A075B5X4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "innate immune response", 
                        "id": "GO:0045087"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050853", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B5X4", 
                                "id": "A0A075B5X4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "B cell receptor signaling pathway", 
                        "id": "GO:0050853"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B5X4", 
                                "id": "A0A075B5X4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "defense response to bacterium", 
                        "id": "GO:0042742"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006910", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B5X4", 
                                "id": "A0A075B5X4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "phagocytosis, recognition", 
                        "id": "GO:0006910"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050871", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B5X4", 
                                "id": "A0A075B5X4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of B cell activation", 
                        "id": "GO:0050871"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006958", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B5X4", 
                                "id": "A0A075B5X4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "complement activation, classical pathway", 
                        "id": "GO:0006958"
                    }
                ], 
                "total": 7, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-173623", 
            "id": "R-MMU-173623", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-198933", 
            "id": "R-MMU-198933", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2029481", 
            "id": "R-MMU-2029481", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2168880", 
            "id": "R-MMU-2168880", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-202733", 
            "id": "R-MMU-202733", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2454202", 
            "id": "R-MMU-2454202", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-977606", 
            "id": "R-MMU-977606", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983695", 
            "id": "R-MMU-983695", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2029485", 
            "id": "R-MMU-2029485", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2029482", 
            "id": "R-MMU-2029482", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2871796", 
            "id": "R-MMU-2871796", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2871809", 
            "id": "R-MMU-2871809", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5690714", 
            "id": "R-MMU-5690714", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-166663", 
            "id": "R-MMU-166663", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2871837", 
            "id": "R-MMU-2871837", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2730905", 
            "id": "R-MMU-2730905", 
            "database": "Reactome"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000095170", 
            "id": "ENSMUSG00000095170", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/HIFWNDE/", 
            "id": "HIFWNDE", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", 
            "id": "IPR007110", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", 
            "id": "IPR013783", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", 
            "id": "IPR036179", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", 
            "id": "IPR013106", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF07686", 
            "id": "PF07686", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:3644925", 
            "id": "3644925", 
            "database": "MGI"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0A075B5X4", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 13082.0, 
        "chemical_mass": 13082.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A075B5X4", 
            "name": "Ighv8-11.", 
            "locus": {
                "end_pos": 115567149, 
                "start_pos": 115567591, 
                "chromosome": "12", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000095170", 
                        "id": "ENSMUSG00000095170", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}