{ "uniprot_canonical_ac": "A2AWR3-1", "sequence": { "header": "tr|A2AWR3-1|A2AWR3_MOUSE Isoform 1 of MCG127722, isoform CRA_b OS=Mus musculus OX=10090 GN=Gpr155 PE=1 SV=1 CANONICAL=A2AWR3-1", "length": 868, "sequence": "MDSYFSAKNSTLAGDMNATWPASHGFNATGDPPSMSITRLFPALLECFGIVLCGYIAGRANIITSTQAKGLGNFVSRFALPALLFKNMVVLNFSNVDWAFLYSVLIGKASVFFIVCVLTLLVASPESRFSKAGLFPIFATQSNDFALGYPIVEALYQSTYPEYLQYIYLVAPISLMMLNPIGFIFCEIQKSKDTQNASQNKAKIVGLGFLRVLQNPIVFMVFVGIAFNFILDKKIPVYMENFLDGLANSFSGSALFYLGLTMVGKIRRLKKSAFVVLTLLITAKLLVLPLLCREMVELLDKGDSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDAKPLAYAIQNVSFDISIISLVSLIWSLSILLLSKKYKQLPHMLTANLLIAQTIVCAGMMIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAVSLFLLKKRESVQLPVGIIIISGWGIPALLVGVLLITGKHNGDSIDSAFFYGKEQMITTAVTLFCSILIAGVSLMCMNRTTQAGHYEGFGQSQNHKPVEPGSTAFEENPAPTNEPELFPSSIPETSCCSCSLGNGELRCPSIEPVTNSSASGPMPSSFEKTDHCVSRCDSQSCILAQEEEQYLQSGDPQLTRHVLLCLLLIIGLFANLSSCLWWLFNHETGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILPFKRRLEFLWNNKEAAADRESPVSEEIKMTCQQFVHYHRDLCIRNIVRERRCGAKTSAGTFCGCDLVNWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQKSPEQSPPARTLRDHQEESYKEIGHSSPPSVSPKT" }, "uniprot_id": "A2AWR3_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "integral membrane protein GPR155 isoform 1", "GPR155 variant 3; GPR155 variant 6" ], "uniprotkb": [ "MCG127722, isoform CRA_b", "G protein-coupled receptor 155", "GPR155 variant 1" ] }, "gene": { "refseq": [ "Gpr155", "1110017O10Rik", " DEPDC3", " F730029F15Rik", " PGR22" ], "uniprotkb": [ "Gpr155", "mCG_127722", "1110017O10Rik", " DEPDC3", " F730029F15Rik", " PGR22" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWR3", "id": "A2AWR3", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "MCG127722, isoform CRA_b; G protein-coupled receptor 155; GPR155 variant 1." }, "publication": [ { "title": "Searching for genomic region of high-fat diet-induced type 2 diabetes in mouse chromosome 2 by analysis of congenic strains.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24789282", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177226.1", "id": "NP_001177226.1", "database": "RefSeq" } ], "authors": "Kobayashi M, Ohno T, Ihara K, Murai A, Kumazawa M, Hoshino H, Iwanaga K, Iwai H, Hamana Y, Ito M, Ohno K, Horio F", "date": "2014", "pmid": "24789282" }, { "title": "GPR155: Gene organization, multiple mRNA splice variants and expression in mouse central nervous system.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20537985", "journal": "Biochemical and biophysical research communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177226.1", "id": "NP_001177226.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AWR3/publications", "id": "A2AWR3", "database": "UniProtKB" } ], "authors": "Trifonov S, Houtani T, Shimizu J, Hamada S, Kase M, Maruyama M, Sugimoto T", "date": "2010", "pmid": "20537985" }, { "title": "The G protein-coupled receptor repertoires of human and mouse.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12679517", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177226.1", "id": "NP_001177226.1", "database": "RefSeq" } ], "authors": "Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA", "date": "2003", "pmid": "12679517" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AWR3#A2AWR3-1", "isoform_ac": "A2AWR3-1", "locus": { "end_pos": 73343460, "start_pos": 73382277, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000112043", "id": "ENSMUST00000112043", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000107674", "id": "ENSMUSP00000107674", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AWR3-1|A2AWR3_MOUSE Isoform 1 of MCG127722, isoform CRA_b OS=Mus musculus OX=10090 GN=Gpr155 PE=1 SV=1 CANONICAL=A2AWR3-1", "length": 868, "sequence": "MDSYFSAKNSTLAGDMNATWPASHGFNATGDPPSMSITRLFPALLECFGIVLCGYIAGRANIITSTQAKGLGNFVSRFALPALLFKNMVVLNFSNVDWAFLYSVLIGKASVFFIVCVLTLLVASPESRFSKAGLFPIFATQSNDFALGYPIVEALYQSTYPEYLQYIYLVAPISLMMLNPIGFIFCEIQKSKDTQNASQNKAKIVGLGFLRVLQNPIVFMVFVGIAFNFILDKKIPVYMENFLDGLANSFSGSALFYLGLTMVGKIRRLKKSAFVVLTLLITAKLLVLPLLCREMVELLDKGDSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDAKPLAYAIQNVSFDISIISLVSLIWSLSILLLSKKYKQLPHMLTANLLIAQTIVCAGMMIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAVSLFLLKKRESVQLPVGIIIISGWGIPALLVGVLLITGKHNGDSIDSAFFYGKEQMITTAVTLFCSILIAGVSLMCMNRTTQAGHYEGFGQSQNHKPVEPGSTAFEENPAPTNEPELFPSSIPETSCCSCSLGNGELRCPSIEPVTNSSASGPMPSSFEKTDHCVSRCDSQSCILAQEEEQYLQSGDPQLTRHVLLCLLLIIGLFANLSSCLWWLFNHETGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILPFKRRLEFLWNNKEAAADRESPVSEEIKMTCQQFVHYHRDLCIRNIVRERRCGAKTSAGTFCGCDLVNWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQKSPEQSPPARTLRDHQEESYKEIGHSSPPSVSPKT" } }, { "url": "https://www.uniprot.org/uniprot/A2AWR3#F6Z6G4-1", "isoform_ac": "F6Z6G4-1", "locus": { "end_pos": 73347734, "start_pos": 73362511, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000131430", "id": "ENSMUST00000131430", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000114294", "id": "ENSMUSP00000114294", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6Z6G4-1|A2AWR3_MOUSE Computationally mapped isoform of MCG127722, isoform CRA_b OS=Mus musculus OX=10090 GN=Gpr155 PE=1 SV=1 CANONICAL=A2AWR3-1", "length": 218, "sequence": "XVEPGSTAFEENPAPTNEPELFPSSIPETSCCSCSLGNGELRCPSIEPVTNSSASGPMPSSFEKTDHCVSRCDSQSCILAQEEEQYLQSGDPQLTRHVLLCLLLIIGLFANLSSCLWWLFNHETGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILPFKRRLEFLWNNKEAAADRESPVSEEIKMTCQQFVHYHRDLCIRNIVRERRYRICCSKK" } }, { "url": "https://www.uniprot.org/uniprot/A2AWR3#A2AWR2-1", "isoform_ac": "A2AWR2-1", "locus": { "end_pos": 73343460, "start_pos": 73382277, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000112044", "id": "ENSMUST00000112044", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000107675", "id": "ENSMUSP00000107675", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AWR2-1|A2AWR3_MOUSE Computationally mapped isoform of MCG127722, isoform CRA_b OS=Mus musculus OX=10090 GN=Gpr155 PE=1 SV=1 CANONICAL=A2AWR3-1", "length": 840, "sequence": "MDSYFSAKNSTLAGDMNATWPASHGFNATGDPPSMSITRLFPALLECFGIVLCGYIAGRANIITSTQAKGLGNFVSRFALPALLFKNMVVLNFSNVDWAFLYSVLIGKASVFFIVCVLTLLVASPESRFSKAGLFPIFATQSNDFALGYPIVEALYQSTYPEYLQYIYLVAPISLMMLNPIGFIFCEIQKSKDTQNASQNKAKIVGLGFLRVLQNPIVFMVFVGIAFNFILDKKIPVYMENFLDGLANSFSGSALFYLGLTMVGKIRRLKKSAFVVLTLLITAKLLVLPLLCREMVELLDKGDSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDAKPLAYAIQNVSFDISIISLVSLTIVCAGMMIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAVSLFLLKKRESVQLPVGIIIISGWGIPALLVGVLLITGKHNGDSIDSAFFYGKEQMITTAVTLFCSILIAGVSLMCMNRTTQAGHYEGFGQSQNHKPVEPGSTAFEENPAPTNEPELFPSSIPETSCCSCSLGNGELRCPSIEPVTNSSASGPMPSSFEKTDHCVSRCDSQSCILAQEEEQYLQSGDPQLTRHVLLCLLLIIGLFANLSSCLWWLFNHETGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILPFKRRLEFLWNNKEAAADRESPVSEEIKMTCQQFVHYHRDLCIRNIVRERRCGAKTSAGTFCGCDLVNWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQKSPEQSPPARTLRDHQEESYKEIGHSSPPSVSPKT" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:68526", "resource": "KEGG Pathway", "id": "mmu:68526", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177226.1", "annotation": "Exome sequencing analysis between SM/J and A/J mice identified 4 genes (Itga6, Zak, Gpr155, and Mtx2) with nonsynonymous coding SNPs. These four genes might be candidate genes for type 2 diabetes caused by gene-gene interactions. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177226.1", "id": "NP_001177226.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177226.1", "annotation": "This study reports the structural organization of mouse GPR155 gene and the generation of five variants (Variants 1-5) of GPR155 mRNA, including so far unknown four variants.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177226.1", "id": "NP_001177226.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZWM3-1", "protein_name": "G protein-coupled receptor 155; G protein-coupled receptor 155 (Predicted), isoform CRA_a.", "sequence": { "length": 868, "sequence": "MDSYFPAKNSTLAVNMNETLSASHGFNSTSDPPPMSITRLFPALLECFGIVLCGYIAGRANVITSTQAKGLGNFVSRFALPALLFKNMVVLNFANVDWAFLYSILIGKASVFFVVCVLTLLVASPESRFSKAGLFPIFATQSNDFALGYPIVEALYQTTYPEYLQYIYLVAPISLMMLNPIGFIFCEIQKSKDTRNASQNKAKIVGLGFLRVLQNPIVFMVFVGIAFNFILDKKIPVYMENFLDGLANSFSGSALFYLGLTMVGKIRRLKKSAFVALIVLITAKLLVLPLLCREMVEVLDKGNSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDAKPLAYAIQNVSFDISIISLVSLIWSLSVLLLSKKYKQLPHMLTANLLIAQTIVCAGMVIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAVSLFLLKKRESVQIPVGLIIISGWGIPALLVGVLLITGKHNGDSVDSAFFYGKEQMITTAVTLFCSILIAGVSLMCMNRTTQAGHYEGFGQSQSHKPVEPGSTAFEESPAPTSEPELFPSSIPETGCCSCSLGNGELRCPSIQPGTNSSASRPRPSSFEKTDQCVSRCDSQSCILAQEEEQYLQSGDPQLTRHVLLCLLLIIGLFANLSSCLWWLFNHETGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILPFKRRLEFLWNNKETAEDRESPVSEEIKMTCQQFVHYHRDLCIRNIVRERRCGAKTSAGTFCGCDLVNWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQKSPERSPPAGTVSNPPEESYKEIGHASPPSLSPKT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/16584", "id": "16584", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q7Z3F1-1", "protein_name": "Integral membrane protein GPR155; G-protein coupled receptor PGR22.", "sequence": { "length": 870, "sequence": "MNSNLPAENLTIAVNMTKTLPTAVTHGFNSTNDPPSMSITRLFPALLECFGIVLCGYIAGRANVITSTQAKGLGNFVSRFALPALLFKNMVVLNFSNVDWSFLYSILIAKASVFFIVCVLTLLVASPDSRFSKAGLFPIFATQSNDFALGYPIVEALYQTTYPEYLQYIYLVAPISLMMLNPIGFIFCEIQKWKDTQNASQNKIKIVGLGLLRVLQNPIVFMVFIGIAFNFILDRKVPVYVENFLDGLGNSFSGSALFYLGLTMVGKIKRLKKSAFVVLILLITAKLLVLPLLCREMVELLDKGDSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDPKPLAYAIQNVSFDISIVSLISLIWSLAILLLSKKYKQLPHMLTTNLLIAQSIVCAGMMIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAISLFLLKKRERVQIPVGIIIISGWGIPALLVGVLLITGKHNGDSIDSAFFYGKEQMITTAVTLFCSILIAGISLMCMNQTAQAGSYEGFDQSQSHKVVEPGNTAFEESPAPVNEPELFTSSIPETSCCSCSMGNGELHCPSIEPIANTSTSEPVIPSFEKNNHCVSRCNSQSCILAQEEEQYLQSGDQQLTRHVLLCLLLIIGLFANLSSCLWWLFNQEPGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILPFKRRLEFLWNNKDTAENRDSPVSEEIKMTCQQFIHYHRDLCIRNIVKERRCGAKTSAGTFCGCDLVSWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQKSPEQSPPAINANTLQQERYKEIEHSSPPSHSPKT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/16584", "id": "16584", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177226.1", "ac": "NP_001177226.1", "name": "integral membrane protein GPR155 isoform 1; GPR155 variant 3; GPR155 variant 6.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWR3", "id": "A2AWR3", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWR3", "id": "A2AWR3", "database": "UniProtKB" } ], "name": "intracellular signal transduction", "id": "GO:0035556" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050890", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWR3", "id": "A2AWR3", "database": "UniProtKB" } ], "name": "cognition", "id": "GO:0050890" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWR3", "id": "A2AWR3", "database": "UniProtKB" } ], "name": "transmembrane transport", "id": "GO:0055085" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 11, "annotation": "n_glycosylation_sequon", "start_pos": 9 }, { "end_pos": 19, "annotation": "n_glycosylation_sequon", "start_pos": 17 }, { "end_pos": 29, "annotation": "n_glycosylation_sequon", "start_pos": 27 }, { "end_pos": 94, "annotation": "n_glycosylation_sequon", "start_pos": 92 }, { "end_pos": 198, "annotation": "n_glycosylation_sequon", "start_pos": 196 }, { "end_pos": 309, "annotation": "n_glycosylation_sequon", "start_pos": 307 }, { "end_pos": 381, "annotation": "n_glycosylation_sequon", "start_pos": 379 }, { "end_pos": 543, "annotation": "n_glycosylation_sequon", "start_pos": 541 }, { "end_pos": 612, "annotation": "n_glycosylation_sequon", "start_pos": 610 }, { "end_pos": 672, "annotation": "n_glycosylation_sequon", "start_pos": 670 } ], "crossref": [ { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "id": "IPR036388", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "id": "IPR036390", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR004776", "id": "IPR004776", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000591", "id": "IPR000591", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037368", "id": "IPR037368", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF03547", "id": "PF03547", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00610", "id": "PF00610", "database": "Pfam" }, { "url": "http://www.informatics.jax.org/marker/MGI:1915776", "id": "1915776", "database": "MGI" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177226.1", "id": "NP_001177226.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:68526", "id": "mmu:68526", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000041762", "id": "ENSMUSG00000041762", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/PHGLPEM/", "id": "PHGLPEM", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04443", "id": "cd04443", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/68526", "id": "68526", "database": "GeneID" } ], "expression_disease": [], "uniprot_ac": "A2AWR3", "disease": [], "mass": { "monoisotopic_mass": 96347.0, "chemical_mass": 96347.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AWR3", "name": "Gpr155; mCG_127722; 1110017O10Rik; DEPDC3; F730029F15Rik; PGR22.", "locus": { "end_pos": 73341506, "start_pos": 73386572, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000041762", "id": "ENSMUSG00000041762", "database": "Ensembl Gene" } ] } } ] }