{ "uniprot_canonical_ac": "A2ASZ8-1", "sequence": { "header": "sp|A2ASZ8-1|SCMC2_MOUSE Isoform 1 of Calcium-binding mitochondrial carrier protein SCaMC-2 OS=Mus musculus OX=10090 GN=Slc25a25 PE=1 SV=1 CANONICAL=A2ASZ8-1", "length": 469, "sequence": "MLCLCLYVPIAGAAQTEFQYFESKGLPAELKSIFKLSVFIPSQEFSTYRQWKQKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMCIVGGFTQMIREGGAKSLWRGNGINVLKIAPESAIKFMAYEQMKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAKEGVAAFYKGYIPNMLGIIPYAGIDLAVYETLKNTWLQRYAVNSADPGVFVLLACGTISSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKQILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR" }, "uniprot_id": "SCMC2_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "calcium-binding mitochondrial carrier protein SCaMC-2 isoform 2", "mitochondrial Ca2+-dependent solute carrier; calcium-binding mitochondrial carrier protein SCaMC-2; solute carrier family 25 member 25; small calcium-binding mitochondrial carrier protein 2" ], "uniprotkb": [ "Calcium-binding mitochondrial carrier protein SCaMC-2", "Small calcium-binding mitochondrial carrier protein 2", "Solute carrier family 25 member 25" ] }, "gene": { "refseq": [ "Slc25a25", "1110030N17Rik", " MCSC", " mKIAA1896" ], "uniprotkb": [ "Slc25a25", "Kiaa1896", "Slc25a25", "Scamc2", "1110030N17Rik", " MCSC", " mKIAA1896" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASZ8", "id": "A2ASZ8", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Calcium-binding mitochondrial carrier protein SCaMC-2; Small calcium-binding mitochondrial carrier protein 2; Solute carrier family 25 member 25." }, "publication": [ { "title": "Ketogenic diet induces expression of the muscle circadian gene Slc25a25 via neural pathway that might be involved in muscle thermogenesis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28588221", "journal": "Scientific reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157829.1", "id": "NP_001157829.1", "database": "RefSeq" } ], "authors": "Nakao R, Shimba S, Oishi K", "date": "2017", "pmid": "28588221" }, { "title": "Glucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+ activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23344948", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157829.1", "id": "NP_001157829.1", "database": "RefSeq" } ], "authors": "Amigo I, Traba J, Gonzalez-Barroso MM, Rueda CB, Fernandez M, Rial E, Sanchez A, Satrustegui J, Del Arco A", "date": "2013", "pmid": "23344948" }, { "title": "Inactivation of the mitochondrial carrier SLC25A25 (ATP-Mg2+/Pi transporter) reduces physical endurance and metabolic efficiency in mice.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21296886", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157829.1", "id": "NP_001157829.1", "database": "RefSeq" } ], "authors": "Anunciado-Koza RP, Zhang J, Ukropec J, Bajpeyi S, Koza RA, Rogers RC, Cefalu WT, Mynatt RL, Kozak LP", "date": "2011", "pmid": "21296886" }, { "title": "Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12819125", "journal": "Genome research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157829.1", "id": "NP_001157829.1", "database": "RefSeq" } ], "authors": "Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T, Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA, Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts P, Muramatsu M, Okazaki Y, Kawai J, Hayashizaki Y", "date": "2003", "pmid": "12819125" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2ASZ8#A2ASZ8-1", "isoform_ac": "A2ASZ8-1", "locus": { "end_pos": 32416141, "start_pos": 32423952, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000113307", "id": "ENSMUST00000113307", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000108932", "id": "ENSMUSP00000108932", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2ASZ8-1|SCMC2_MOUSE Isoform 1 of Calcium-binding mitochondrial carrier protein SCaMC-2 OS=Mus musculus OX=10090 GN=Slc25a25 PE=1 SV=1 CANONICAL=A2ASZ8-1", "length": 469, "sequence": "MLCLCLYVPIAGAAQTEFQYFESKGLPAELKSIFKLSVFIPSQEFSTYRQWKQKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMCIVGGFTQMIREGGAKSLWRGNGINVLKIAPESAIKFMAYEQMKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAKEGVAAFYKGYIPNMLGIIPYAGIDLAVYETLKNTWLQRYAVNSADPGVFVLLACGTISSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKQILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR" } }, { "url": "https://www.uniprot.org/uniprot/A2ASZ8#Z4YLR9-1", "isoform_ac": "Z4YLR9-1", "locus": { "end_pos": 32417418, "start_pos": 32431105, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000136361", "id": "ENSMUST00000136361", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000115617", "id": "ENSMUSP00000115617", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Z4YLR9-1|SCMC2_MOUSE Computationally mapped isoform of Calcium-binding mitochondrial carrier protein SCaMC-2 OS=Mus musculus OX=10090 GN=Slc25a25 PE=1 SV=1 CANONICAL=A2ASZ8-1", "length": 263, "sequence": "MTGSPKLFPSPGKVYLDIIFALQKEQKRSQVFDLPPAEKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMCIVGGFTQMIREGGAKSLWRGNGINVLKIAPESAIKFMAYEQMKRLVGSDQETL" } }, { "url": "https://www.uniprot.org/uniprot/A2ASZ8#A2ASZ8-2", "isoform_ac": "A2ASZ8-2", "locus": { "end_pos": 32416141, "start_pos": 32451324, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000113310", "id": "ENSMUST00000113310", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000108936", "id": "ENSMUSP00000108936", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2ASZ8-2|SCMC2_MOUSE Isoform 2 of Calcium-binding mitochondrial carrier protein SCaMC-2 OS=Mus musculus OX=10090 GN=Slc25a25 PE=1 SV=1 CANONICAL=A2ASZ8-1", "length": 502, "sequence": "MVSSVLCRCVASPPPDAAATASSSASSPASVGDPCGGAVCGGPDHQLRLWSLFQTLDVNRDGGLCVNDLAVGLRRLGLHRTEGELRKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMCIVGGFTQMIREGGAKSLWRGNGINVLKIAPESAIKFMAYEQMKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAKEGVAAFYKGYIPNMLGIIPYAGIDLAVYETLKNTWLQRYAVNSADPGVFVLLACGTISSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKQILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR" } }, { "url": "https://www.uniprot.org/uniprot/A2ASZ8#A0A0A6YWC1-1", "isoform_ac": "A0A0A6YWC1-1", "locus": { "end_pos": 32419048, "start_pos": 32421367, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000153886", "id": "ENSMUST00000153886", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000141486", "id": "ENSMUSP00000141486", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0A6YWC1-1|SCMC2_MOUSE Computationally mapped isoform of Calcium-binding mitochondrial carrier protein SCaMC-2 OS=Mus musculus OX=10090 GN=Slc25a25 PE=1 SV=1 CANONICAL=A2ASZ8-1", "length": 112, "sequence": "MQSLRDLGVKISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQ" } }, { "url": "https://www.uniprot.org/uniprot/A2ASZ8#A2ASZ8-3", "isoform_ac": "A2ASZ8-3", "locus": { "end_pos": 32416141, "start_pos": 32451324, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000028160", "id": "ENSMUST00000028160", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000028160", "id": "ENSMUSP00000028160", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2ASZ8-3|SCMC2_MOUSE Isoform 3 of Calcium-binding mitochondrial carrier protein SCaMC-2 OS=Mus musculus OX=10090 GN=Slc25a25 PE=1 SV=1 CANONICAL=A2ASZ8-1", "length": 514, "sequence": "MVSSVLCRCVASPPPDAAATASSSASSPASVGDPCGGAVCGGPDHQLRLWSLFQTLDVNRDGGLCVNDLAVGLRRLGLHRTEGELRKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAEKILKRIRTGHFWGPVTYMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMCIVGGFTQMIREGGAKSLWRGNGINVLKIAPESAIKFMAYEQMKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAKEGVAAFYKGYIPNMLGIIPYAGIDLAVYETLKNTWLQRYAVNSADPGVFVLLACGTISSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKQILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR" } }, { "url": "https://www.uniprot.org/uniprot/A2ASZ8#F6RC04-1", "isoform_ac": "F6RC04-1", "locus": { "end_pos": 32419131, "start_pos": 32431104, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000127961", "id": "ENSMUST00000127961", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000121932", "id": "ENSMUSP00000121932", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6RC04-1|SCMC2_MOUSE Computationally mapped isoform of Calcium-binding mitochondrial carrier protein SCaMC-2 OS=Mus musculus OX=10090 GN=Slc25a25 PE=1 SV=1 CANONICAL=A2ASZ8-1", "length": 184, "sequence": "XTGSPKLFPSPGKVYLDIIFALQKEQKRSQVFDLPPAEKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAEKILKRIRTGHFWGPVTYMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWW" } }, { "url": "https://www.uniprot.org/uniprot/A2ASZ8#A2ASZ8-4", "isoform_ac": "A2ASZ8-4", "locus": { "end_pos": 32416141, "start_pos": 32430747, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000113308", "id": "ENSMUST00000113308", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000108933", "id": "ENSMUSP00000108933", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2ASZ8-4|SCMC2_MOUSE Isoform 4 of Calcium-binding mitochondrial carrier protein SCaMC-2 OS=Mus musculus OX=10090 GN=Slc25a25 PE=1 SV=1 CANONICAL=A2ASZ8-1", "length": 489, "sequence": "MLQTLWHFLSSFLPRAECQDSREGIDHGVRGTQAPARGDQMSTFLGKQNGRAEATEKRPTILLVVGPAEQFPKKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMCIVGGFTQMIREGGAKSLWRGNGINVLKIAPESAIKFMAYEQMKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAKEGVAAFYKGYIPNMLGIIPYAGIDLAVYETLKNTWLQRYAVNSADPGVFVLLACGTISSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKQILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR" } }, { "url": "https://www.uniprot.org/uniprot/A2ASZ8#A2ASZ8-5", "isoform_ac": "A2ASZ8-5", "locus": { "end_pos": 32416141, "start_pos": 32430747, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000052119", "id": "ENSMUST00000052119", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000060581", "id": "ENSMUSP00000060581", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2ASZ8-5|SCMC2_MOUSE Isoform 5 of Calcium-binding mitochondrial carrier protein SCaMC-2 OS=Mus musculus OX=10090 GN=Slc25a25 PE=1 SV=1 CANONICAL=A2ASZ8-1", "length": 501, "sequence": "MLQTLWHFLSSFLPRAECQDSREGIDHGVRGTQAPARGDQMSTFLGKQNGRAEATEKRPTILLVVGPAEQFPKKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAEKILKRIRTGHFWGPVTYMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMCIVGGFTQMIREGGAKSLWRGNGINVLKIAPESAIKFMAYEQMKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAKEGVAAFYKGYIPNMLGIIPYAGIDLAVYETLKNTWLQRYAVNSADPGVFVLLACGTISSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKQILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:227731", "resource": "KEGG Pathway", "id": "mmu:227731", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2ASZ8#function", "annotation": "Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASZ8#function", "id": "A2ASZ8", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157829.1", "annotation": "These findings suggest that KD feeding induces expression of the muscle circadian gene Slc25a25 via neural pathways, and that SLC25A25 might be involved in muscle thermogenesis under KD-induced hypothermia in mammals. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157829.1", "id": "NP_001157829.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157829.1", "annotation": "Induction of Slc25a25 in mice with an intact gene may contribute to an alternative thermogenic pathway for the maintenance of body temperature during cold stress.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157829.1", "id": "NP_001157829.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q6KCM7-1", "protein_name": "Calcium-binding mitochondrial carrier protein SCaMC-2; Mitochondrial Ca(2+)-dependent solute carrier protein 3; Small calcium-binding mitochondrial carrier protein 2; Pi carrier protein 3; Solute carrier family 25 member 25.", "sequence": { "length": 469, "sequence": "MLCLCLYVPVIGEAQTEFQYFESKGLPAELKSIFKLSVFIPSQEFSTYRQWKQKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/62165", "id": "62165", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2ASZ8/", "id": "A2ASZ8", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q8K3P6-1", "protein_name": "Calcium-binding mitochondrial carrier protein SCaMC-2; Pi carrier protein; Small calcium-binding mitochondrial carrier protein 2; Peroxisomal Ca(2+)-dependent solute carrier-like protein; Solute carrier family 25 member 25.", "sequence": { "length": 469, "sequence": "MLCLCLYVPIAGEAQTEFQYFESKGLPTELKSIFKLSVFIPSQEFSTYRQWKQKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMCIIGGFTQMIREGGAKSLWRGNGINVLKIAPESAIKFMAYEQMKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCAKRILAKEGVAAFYKGYIPNMLGIIPYAGIDLAVYETLKNTWLQRYAVNSADPGVFVLLACGTISSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKQILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/62165", "id": "62165", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2ASZ8/", "id": "A2ASZ8", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157829.1", "ac": "NP_001157829.1", "name": "calcium-binding mitochondrial carrier protein SCaMC-2 isoform 2; mitochondrial Ca2+-dependent solute carrier; calcium-binding mitochondrial carrier protein SCaMC-2; solute carrier family 25 member 25; small calcium-binding mitochondrial carrier protein 2.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005347", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASZ8", "id": "A2ASZ8", "database": "UniProtKB" } ], "name": "ATP transmembrane transporter activity", "id": "GO:0005347" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASZ8", "id": "A2ASZ8", "database": "UniProtKB" } ], "name": "calcium ion binding", "id": "GO:0005509" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASZ8", "id": "A2ASZ8", "database": "UniProtKB" } ], "name": "mitochondrion", "id": "GO:0005739" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASZ8", "id": "A2ASZ8", "database": "UniProtKB" } ], "name": "mitochondrial inner membrane", "id": "GO:0005743" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASZ8", "id": "A2ASZ8", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060612", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASZ8", "id": "A2ASZ8", "database": "UniProtKB" } ], "name": "adipose tissue development", "id": "GO:0060612" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032094", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASZ8", "id": "A2ASZ8", "database": "UniProtKB" } ], "name": "response to food", "id": "GO:0032094" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035264", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASZ8", "id": "A2ASZ8", "database": "UniProtKB" } ], "name": "multicellular organism growth", "id": "GO:0035264" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014823", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASZ8", "id": "A2ASZ8", "database": "UniProtKB" } ], "name": "response to activity", "id": "GO:0014823" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070588", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASZ8", "id": "A2ASZ8", "database": "UniProtKB" } ], "name": "calcium ion transmembrane transport", "id": "GO:0070588" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASZ8", "id": "A2ASZ8", "database": "UniProtKB" } ], "name": "response to dietary excess", "id": "GO:0002021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046034", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASZ8", "id": "A2ASZ8", "database": "UniProtKB" } ], "name": "ATP metabolic process", "id": "GO:0046034" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043010", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASZ8", "id": "A2ASZ8", "database": "UniProtKB" } ], "name": "camera-type eye development", "id": "GO:0043010" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045333", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASZ8", "id": "A2ASZ8", "database": "UniProtKB" } ], "name": "cellular respiration", "id": "GO:0045333" } ], "total": 9, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 131, "annotation": "n_glycosylation_sequon", "start_pos": 129 }, { "end_pos": 171, "annotation": "n_glycosylation_sequon", "start_pos": 169 } ], "crossref": [ { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2ASZ8*", "id": "A2ASZ8", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002067", "id": "IPR002067", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018108", "id": "IPR018108", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR023395", "id": "IPR023395", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "id": "IPR002048", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "id": "IPR011992", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002167", "id": "IPR002167", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00153", "id": "PF00153", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF13499", "id": "PF13499", "database": "Pfam" }, { "url": "http://www.informatics.jax.org/marker/MGI:1915913", "id": "1915913", "database": "MGI" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157829.1", "id": "NP_001157829.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:227731", "id": "mmu:227731", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000026819", "id": "ENSMUSG00000026819", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/FWRHSTM/", "id": "FWRHSTM", "database": "OMA" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2ASZ8", "id": "PR_A2ASZ8", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/227731", "id": "227731", "database": "GeneID" } ], "expression_disease": [], "uniprot_ac": "A2ASZ8", "disease": [], "mass": { "monoisotopic_mass": 52621.0, "chemical_mass": 52621.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2ASZ8", "name": "Slc25a25; Kiaa1896; Slc25a25; Scamc2; 1110030N17Rik; MCSC; mKIAA1896.", "locus": { "end_pos": 32414487, "start_pos": 32451445, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000026819", "id": "ENSMUSG00000026819", "database": "Ensembl Gene" } ] } } ] }