{
    "uniprot_canonical_ac": "A2RUS2-1", 
    "sequence": {
        "header": "sp|A2RUS2-1|DEND3_HUMAN Isoform 1 of DENN domain-containing protein 3  OS=Homo sapiens OX=9606 GN=DENND3 PE=1 SV=2 CANONICAL=A2RUS2-1", 
        "length": 1198, 
        "sequence": "MRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQLHHELHAAHLLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHLNYEHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKARLNRRMDAFAQMDLDTQSEEDRINGMLLSPRRPTVEKRASRKSSHLHVTHRRMVVSMPNLQDIAMPELAPRNSSLRLTDTAGCRGSSAVLNVTPKSPYTFKIPEIHFPLESKCVQAYHAHFVSMLSEAMCFLAPDNSLLLARYLYLRGLVYLMQGQLLNALLDFQNLYKTDIRIFPTDLVKRTVESMSAPEWEGAEQAPELMRLISEILDKPHEASKLDDHVKKFKLPKKHMQLGDFMKRVQESGIVKDASIIHRLFEALTVGQEKQIDPETFKDFYNCWKETEAEAQEVSLPWLVMEHLDKNECVCKLSSSVKTNLGVGKIAMTQKRLFLLTEGRPGYLEISTFRNIEEVRRTTTTFLLRRIPTLKIRVASKKEVFEANLKTECDLWHLMVKEMWAGKKLADDHKDPHYVQQALTNVLLMDAVVGTLQSPGAIYAASKLSYFDKMSNEMPMTLPETTLETLKHKINPSAGEAFPQAVDVLLYTPGHLDPAEKVEDAHPKLWCALSEGKVTVFNASSWTIHQHSFKVGTAKVNCMVMADQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIVQDGQEAPSNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLHGGRLWCCTGNSIMVMKMNGSLHQELKIEENFKDTSTSFLAFQLLPEEEQLWAACAGRSEVYIWSLKDLAQPPQRVPLEDCSEINCMIRVKKQVWVGSRGLGQGTPKGKIYVIDAERKTVEKELVAHMDTVRTLCSAEDRYVLSGSGREEGKVAIWKGE"
    }, 
    "uniprot_id": "DEND3_HUMAN", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "DENN domain-containing protein 3 isoform 2", 
                "DENN domain-containing protein 3; DENN/MADD domain containing 3"
            ], 
            "uniprotkb": [
                "DENN domain-containing protein 3"
            ]
        }, 
        "gene": {
            "refseq": [], 
            "uniprotkb": [
                "DENND3", 
                "KIAA0870"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RUS2", 
                    "id": "A2RUS2", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "DENN domain-containing protein 3."
    }, 
    "publication": [
        {
            "title": "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/20937701", 
            "journal": "J. Cell Biol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RUS2/publications", 
                    "id": "A2RUS2", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Barr F.A., Yoshimura S., Gerondopoulos A., Linford A., Rigden D.J.", 
            "date": "2010", 
            "pmid": "20937701"
        }
    ], 
    "glycosylation": [], 
    "mutation": [
        {
            "start_pos": 211, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUS2", 
                    "id": "A2RUS2", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "L", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "M", 
            "subjects_tested": "50", 
            "end_pos": 211, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 830, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUS2", 
                    "id": "A2RUS2", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs1164686761.", 
            "sequence_org": "A", 
            "disease": {
                "doid": "10534", 
                "url": "http://disease-ontology.org/term/DOID:10534", 
                "icd10": "", 
                "name": "Stomach cancer"
            }, 
            "sequence_mut": "V", 
            "subjects_tested": "1044", 
            "end_pos": 830, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 217, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUS2", 
                    "id": "A2RUS2", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.6", 
            "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs571831372.", 
            "sequence_org": "V", 
            "disease": {
                "doid": "2174", 
                "url": "http://disease-ontology.org/term/DOID:2174", 
                "icd10": "", 
                "name": "Ocular cancer"
            }, 
            "sequence_mut": "I", 
            "subjects_tested": "160", 
            "end_pos": 217, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 1022, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUS2", 
                    "id": "A2RUS2", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "Q", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "R", 
            "subjects_tested": "50", 
            "end_pos": 1022, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 670, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUS2", 
                    "id": "A2RUS2", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.5", 
            "annotation": "Filters passed (1/5): patient freq. (1.5%).", 
            "sequence_org": "H", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "L", 
            "subjects_tested": "66", 
            "end_pos": 670, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 217, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUS2", 
                    "id": "A2RUS2", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.2", 
            "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs571831372.", 
            "sequence_org": "V", 
            "disease": {
                "doid": "363", 
                "url": "http://disease-ontology.org/term/DOID:363", 
                "icd10": "", 
                "name": "Uterine cancer"
            }, 
            "sequence_mut": "I", 
            "subjects_tested": "558", 
            "end_pos": 217, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 38, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUS2", 
                    "id": "A2RUS2", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.5", 
            "annotation": "Filters passed (1/5): patient freq. (1.5%).", 
            "sequence_org": "D", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "A", 
            "subjects_tested": "66", 
            "end_pos": 38, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 830, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUS2", 
                    "id": "A2RUS2", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs1164686761.", 
            "sequence_org": "A", 
            "disease": {
                "doid": "11934", 
                "url": "http://disease-ontology.org/term/DOID:11934", 
                "icd10": "", 
                "name": "Head and neck cancer"
            }, 
            "sequence_mut": "V", 
            "subjects_tested": "980", 
            "end_pos": 830, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 719, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUS2", 
                    "id": "A2RUS2", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.5", 
            "annotation": "Filters passed (1/5): patient freq. (1.5%).", 
            "sequence_org": "N", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "K", 
            "subjects_tested": "66", 
            "end_pos": 719, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 217, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUS2", 
                    "id": "A2RUS2", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs571831372.", 
            "sequence_org": "V", 
            "disease": {
                "doid": "10534", 
                "url": "http://disease-ontology.org/term/DOID:10534", 
                "icd10": "", 
                "name": "Stomach cancer"
            }, 
            "sequence_mut": "I", 
            "subjects_tested": "1044", 
            "end_pos": 217, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 2, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUS2", 
                    "id": "A2RUS2", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.3", 
            "annotation": "Filters passed (1/5): patient freq. (1.3%).", 
            "sequence_org": "R", 
            "disease": {
                "doid": "1319", 
                "url": "http://disease-ontology.org/term/DOID:1319", 
                "icd10": "", 
                "name": "Brain cancer"
            }, 
            "sequence_mut": "H", 
            "subjects_tested": "78", 
            "end_pos": 2, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 830, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUS2", 
                    "id": "A2RUS2", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.4", 
            "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs1164686761.", 
            "sequence_org": "A", 
            "disease": {
                "doid": "9256", 
                "url": "http://disease-ontology.org/term/DOID:9256", 
                "icd10": "", 
                "name": "Colorectal cancer"
            }, 
            "sequence_mut": "V", 
            "subjects_tested": "254", 
            "end_pos": 830, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 551, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUS2", 
                    "id": "A2RUS2", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "D", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "N", 
            "subjects_tested": "50", 
            "end_pos": 551, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RUS2#A2RUS2-2", 
            "isoform_ac": "A2RUS2-2", 
            "locus": {
                "end_pos": 141136647, 
                "start_pos": 141194230, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000424248", 
                        "id": "ENST00000424248", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000410594", 
                        "id": "ENSP00000410594", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2RUS2-2|DEND3_HUMAN Isoform 2 of DENN domain-containing protein 3  OS=Homo sapiens OX=9606 GN=DENND3 PE=1 SV=2 CANONICAL=A2RUS2-1", 
                "length": 1146, 
                "sequence": "MRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRDVKNHLNYEHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKARLNRRMDAFAQMDLDTQSEEDRINGMLLSPRRPTVEKRASRKSSHLHVTHRRMVVSMPNLQDIAMPELAPRNSSLRLTDTAGCRGSSAVLNVTPKSPYTFKIPEIHFPLESKCVQAYHAHFVSMLSEAMCFLAPDNSLLLARYLYLRGLVYLMQGQLLNALLDFQNLYKTDIRIFPTDLVKRTVESMSAPEWEGAEQAPELMRLISEILDKPHEASKLDDHVKKFKLPKKHMQLGDFMKRVQESGIVKDASIIHRLFEALTVGQEKQIDPETFKDFYNCWKETEAEAQEVSLPWLVMEHLDKNECVCKLSSSVKTNLGVGKIAMTQKRLFLLTEGRPGYLEISTFRNIEEVRRTTTTFLLRRIPTLKIRVASKKEVFEANLKTECDLWHLMVKEMWAGKKLADDHKDPHYVQQALTNVLLMDAVVGTLQSPGAIYAASKLSYFDKMSNEMPMTLPETTLETLKHKINPSAGEAFPQAVDVLLYTPGHLDPAEKVEDAHPKLWCALSEGKVTVFNASSWTIHQHSFKVGTAKVNCMVMADQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIVQDGQEAPSNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLHGGRLWCCTGNSIMVMKMNGSLHQELKIEENFKDTSTSFLAFQLLPEEEQLWAACAGRSEVYIWSLKDLAQPPQRVPLEDCSEINCMIRVKKQVWVGSRGLGQGTPKGKIYVIDAERKTVEKELVAHMDTVRTLCSAEDRYVLSGSGREEGKVAIWKGE"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RUS2#E5RI43-1", 
            "isoform_ac": "E5RI43-1", 
            "locus": {
                "end_pos": 141128708, 
                "start_pos": 141150908, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000523058", 
                        "id": "ENST00000523058", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000430786", 
                        "id": "ENSP00000430786", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|E5RI43-1|DEND3_HUMAN Computationally mapped isoform of DENN domain-containing protein 3  OS=Homo sapiens OX=9606 GN=DENND3 PE=1 SV=1 CANONICAL=A2RUS2-1", 
                "length": 291, 
                "sequence": "MAEAASPHLSLPSGLLELCALLGAPRDSLRSLEQVAYKKGVKHLSALLDPEVLSIFVPPFISKEDSQMAGANCGTLGKTRMRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLVQPCLSSHSVNTEFELKCDFKVFNMKSLQIVLPARADPESPILDLD"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RUS2#A2RUS2-3", 
            "isoform_ac": "A2RUS2-3", 
            "locus": {
                "end_pos": 0, 
                "start_pos": 0, 
                "chromosome": "", 
                "evidence": []
            }, 
            "sequence": {
                "header": "sp|A2RUS2-3|DEND3_HUMAN Isoform 3 of DENN domain-containing protein 3  OS=Homo sapiens OX=9606 GN=DENND3 PE=1 SV=2 CANONICAL=A2RUS2-1", 
                "length": 266, 
                "sequence": "MVMADQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIVQDGQEAPSNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLHGGRLWCCTGNSIMVMKMNGSLHQELKIEENFKDTSTSFLAFQLLPEEEQLWAACAGRSEVYIWSLKDLAQPPQRVPLEDCSEINCMIRVKKQVGWRARHPQHPRQVSLALAASPCSREPAARPRALLPSPLRVPLLTGTCRVGANGPTGHHVLVSWCGPSTPQRIPPNWMASNDRT"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RUS2#E5RHH2-1", 
            "isoform_ac": "E5RHH2-1", 
            "locus": {
                "end_pos": 141128708, 
                "start_pos": 141151837, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000520986", 
                        "id": "ENST00000520986", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000429780", 
                        "id": "ENSP00000429780", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|E5RHH2-1|DEND3_HUMAN Computationally mapped isoform of DENN domain-containing protein 3  OS=Homo sapiens OX=9606 GN=DENND3 PE=1 SV=1 CANONICAL=A2RUS2-1", 
                "length": 280, 
                "sequence": "MAEAASPHLSLPSGLLELCALLGAPRDSLRSLEQVAYKKGVKHLSALLDPEVLSIFVPPFISKEDSQMAGANCGTLGKTRMRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSK"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RUS2#A2RUS2-4", 
            "isoform_ac": "A2RUS2-4", 
            "locus": {
                "end_pos": 0, 
                "start_pos": 0, 
                "chromosome": "", 
                "evidence": []
            }, 
            "sequence": {
                "header": "sp|A2RUS2-4|DEND3_HUMAN Isoform 4 of DENN domain-containing protein 3  OS=Homo sapiens OX=9606 GN=DENND3 PE=1 SV=2 CANONICAL=A2RUS2-1", 
                "length": 128, 
                "sequence": "MRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSW"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RUS2#E5RIR7-1", 
            "isoform_ac": "E5RIR7-1", 
            "locus": {
                "end_pos": 141128708, 
                "start_pos": 141141325, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000518347", 
                        "id": "ENST00000518347", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000430695", 
                        "id": "ENSP00000430695", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|E5RIR7-1|DEND3_HUMAN Computationally mapped isoform of DENN domain-containing protein 3  OS=Homo sapiens OX=9606 GN=DENND3 PE=1 SV=1 CANONICAL=A2RUS2-1", 
                "length": 208, 
                "sequence": "MAEAASPHLSLPSGLLELCALLGAPRDSLRSLEQVAYKKGVKHLSALLDPEVLSIFVPPFISKEDSQMAGANCGTLGKTRMRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSW"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RUS2#A2RUS2-1", 
            "isoform_ac": "A2RUS2-1", 
            "locus": {
                "end_pos": 141136647, 
                "start_pos": 141194230, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000262585", 
                        "id": "ENST00000262585", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000262585", 
                        "id": "ENSP00000262585", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2RUS2-1|DEND3_HUMAN Isoform 1 of DENN domain-containing protein 3  OS=Homo sapiens OX=9606 GN=DENND3 PE=1 SV=2 CANONICAL=A2RUS2-1", 
                "length": 1198, 
                "sequence": "MRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQLHHELHAAHLLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHLNYEHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKARLNRRMDAFAQMDLDTQSEEDRINGMLLSPRRPTVEKRASRKSSHLHVTHRRMVVSMPNLQDIAMPELAPRNSSLRLTDTAGCRGSSAVLNVTPKSPYTFKIPEIHFPLESKCVQAYHAHFVSMLSEAMCFLAPDNSLLLARYLYLRGLVYLMQGQLLNALLDFQNLYKTDIRIFPTDLVKRTVESMSAPEWEGAEQAPELMRLISEILDKPHEASKLDDHVKKFKLPKKHMQLGDFMKRVQESGIVKDASIIHRLFEALTVGQEKQIDPETFKDFYNCWKETEAEAQEVSLPWLVMEHLDKNECVCKLSSSVKTNLGVGKIAMTQKRLFLLTEGRPGYLEISTFRNIEEVRRTTTTFLLRRIPTLKIRVASKKEVFEANLKTECDLWHLMVKEMWAGKKLADDHKDPHYVQQALTNVLLMDAVVGTLQSPGAIYAASKLSYFDKMSNEMPMTLPETTLETLKHKINPSAGEAFPQAVDVLLYTPGHLDPAEKVEDAHPKLWCALSEGKVTVFNASSWTIHQHSFKVGTAKVNCMVMADQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIVQDGQEAPSNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLHGGRLWCCTGNSIMVMKMNGSLHQELKIEENFKDTSTSFLAFQLLPEEEQLWAACAGRSEVYIWSLKDLAQPPQRVPLEDCSEINCMIRVKKQVWVGSRGLGQGTPKGKIYVIDAERKTVEKELVAHMDTVRTLCSAEDRYVLSGSGREEGKVAIWKGE"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RUS2#H0YAW2-1", 
            "isoform_ac": "H0YAW2-1", 
            "locus": {
                "end_pos": 141141203, 
                "start_pos": 141142483, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000518249", 
                        "id": "ENST00000518249", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000428155", 
                        "id": "ENSP00000428155", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|H0YAW2-1|DEND3_HUMAN Computationally mapped isoform of DENN domain-containing protein 3  OS=Homo sapiens OX=9606 GN=DENND3 PE=1 SV=1 CANONICAL=A2RUS2-1", 
                "length": 102, 
                "sequence": "DEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSWPRRKQLTTVPFCVIMLENEPRQIAELVLFLLLAKHSHLRPSALTRGTSPMESEQEPYCSNQ"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RUS2#H0YBK9-1", 
            "isoform_ac": "H0YBK9-1", 
            "locus": {
                "end_pos": 141192331, 
                "start_pos": 141192916, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000520725", 
                        "id": "ENST00000520725", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000429725", 
                        "id": "ENSP00000429725", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|H0YBK9-1|DEND3_HUMAN Computationally mapped isoform of DENN domain-containing protein 3  OS=Homo sapiens OX=9606 GN=DENND3 PE=1 SV=1 CANONICAL=A2RUS2-1", 
                "length": 170, 
                "sequence": "XTGNSIMVMKMNGSLHQELKIEENFKDTSTSFLAFQLLPEEEQLWAACAGRSEVYIWSLKDLAQPPQRVPLEDCSEINCMIRVKKQVGWRARHPQHPRQVSLALAASPCSREPAARPRALLPSPLRVPLLTGTCRVGANGPTGHHVLVSWCGPSTPQRIPPNWMASNDRT"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RUS2#H0YAY3-1", 
            "isoform_ac": "H0YAY3-1", 
            "locus": {
                "end_pos": 141128779, 
                "start_pos": 141194232, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000518668", 
                        "id": "ENST00000518668", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000428276", 
                        "id": "ENSP00000428276", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|H0YAY3-1|DEND3_HUMAN Computationally mapped isoform of DENN domain-containing protein 3  OS=Homo sapiens OX=9606 GN=DENND3 PE=1 SV=1 CANONICAL=A2RUS2-1", 
                "length": 1203, 
                "sequence": "XPRDSLRSLEQVAYKKGVKHLSALLDPEVLSIFVPPFISKEDSQMAGANCGTLGKTRMRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRDVKNHLNYEHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKARLNRRMDAFAQMDLDTQSEEDRINGMLLSPRRPTVEKRASRKSSHLHVTHRRMVVSMPNLQDIAMPELAPRNSSLRLTDTAGCRGSSAVLNVTPKSPYTFKIPEIHFPLESKCVQAYHAHFVSMLSEAMCFLAPDNSLLLARYLYLRGLVYLMQGQLLNALLDFQNLYKTDIRIFPTDLVKRTVESMSAPEWEGAEQAPELMRLISEILDKPHEASKLDDHVKKFKLPKKHMQLGDFMKRVQESGIVKDASIIHRLFEALTVGQEKQIDPETFKDFYNCWKETEAEAQEVSLPWLVMEHLDKNECVCKLSSSVKTNLGVGKIAMTQKRLFLLTEGRPGYLEISTFRNIEEVRRTTTTFLLRRIPTLKIRVASKKEVFEANLKTECDLWHLMVKEMWAGKKLADDHKDPHYVQQALTNVLLMDAVVGTLQSPGAIYAASKLSYFDKMSNEMPMTLPETTLETLKHKINPSAGEAFPQAVDVLLYTPGHLDPAEKVEDAHPKLWCALSEGKVTVFNASSWTIHQHSFKVGTAKVNCMVMADQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIVQDGQEAPSNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLHGGRLWCCTGNSIMVMKMNGSLHQELKIEENFKDTSTSFLAFQLLPEEEQLWAACAGRSEVYIWSLKDLAQPPQRVPLEDCSEINCMIRVKKQVWVGSRGLGQGTPKGKIYVIDAERKTVEKELVAHMDTVRTLCSAEDRYVLSGSGREEGKVAIWKGE"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RUS2#E5RJ42-1", 
            "isoform_ac": "E5RJ42-1", 
            "locus": {
                "end_pos": 141136608, 
                "start_pos": 141141274, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000519291", 
                        "id": "ENST00000519291", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000430625", 
                        "id": "ENSP00000430625", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|E5RJ42-1|DEND3_HUMAN Computationally mapped isoform of DENN domain-containing protein 3  OS=Homo sapiens OX=9606 GN=DENND3 PE=1 SV=8 CANONICAL=A2RUS2-1", 
                "length": 124, 
                "sequence": "MAGANCGTLGKTRMRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVC"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RUS2#E5RH95-1", 
            "isoform_ac": "E5RH95-1", 
            "locus": {
                "end_pos": 141128708, 
                "start_pos": 141136656, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000518198", 
                        "id": "ENST00000518198", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000428641", 
                        "id": "ENSP00000428641", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|E5RH95-1|DEND3_HUMAN Computationally mapped isoform of DENN domain-containing protein 3  OS=Homo sapiens OX=9606 GN=DENND3 PE=1 SV=1 CANONICAL=A2RUS2-1", 
                "length": 67, 
                "sequence": "MAEAASPHLSLPSGLLELCALLGAPRDSLRSLEQRSCPFSCLLLSVKRTVKWPVPTAALSVKPGCAP"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RUS2#H0YBH5-1", 
            "isoform_ac": "H0YBH5-1", 
            "locus": {
                "end_pos": 141178121, 
                "start_pos": 141185320, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000517985", 
                        "id": "ENST00000517985", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000429533", 
                        "id": "ENSP00000429533", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|H0YBH5-1|DEND3_HUMAN Computationally mapped isoform of DENN domain-containing protein 3  OS=Homo sapiens OX=9606 GN=DENND3 PE=1 SV=1 CANONICAL=A2RUS2-1", 
                "length": 122, 
                "sequence": "VGTLQSPGAIYAASKLSYFDKMSNEMPMTLPETTLETLKHKINPSAGEAFPQAVDVLLYTPGHLDPAEKVEDAHPKLWCALSEGKVTVFNASSWTIHQHSFKVGTAKVVSTRSVRKEASEFT"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RUS2#E9PF32-1", 
            "isoform_ac": "E9PF32-1", 
            "locus": {
                "end_pos": 141128708, 
                "start_pos": 141194230, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000519811", 
                        "id": "ENST00000519811", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000428714", 
                        "id": "ENSP00000428714", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|E9PF32-1|DEND3_HUMAN Computationally mapped isoform of DENN domain-containing protein 3  OS=Homo sapiens OX=9606 GN=DENND3 PE=1 SV=1 CANONICAL=A2RUS2-1", 
                "length": 1278, 
                "sequence": "MAEAASPHLSLPSGLLELCALLGAPRDSLRSLEQVAYKKGVKHLSALLDPEVLSIFVPPFISKEDSQMAGANCGTLGKTRMRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQLHHELHAAHLLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHLNYEHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKARLNRRMDAFAQMDLDTQSEEDRINGMLLSPRRPTVEKRASRKSSHLHVTHRRMVVSMPNLQDIAMPELAPRNSSLRLTDTAGCRGSSAVLNVTPKSPYTFKIPEIHFPLESKCVQAYHAHFVSMLSEAMCFLAPDNSLLLARYLYLRGLVYLMQGQLLNALLDFQNLYKTDIRIFPTDLVKRTVESMSAPEWEGAEQAPELMRLISEILDKPHEASKLDDHVKKFKLPKKHMQLGDFMKRVQESGIVKDASIIHRLFEALTVGQEKQIDPETFKDFYNCWKETEAEAQEVSLPWLVMEHLDKNECVCKLSSSVKTNLGVGKIAMTQKRLFLLTEGRPGYLEISTFRNIEEVRRTTTTFLLRRIPTLKIRVASKKEVFEANLKTECDLWHLMVKEMWAGKKLADDHKDPHYVQQALTNVLLMDAVVGTLQSPGAIYAASKLSYFDKMSNEMPMTLPETTLETLKHKINPSAGEAFPQAVDVLLYTPGHLDPAEKVEDAHPKLWCALSEGKVTVFNASSWTIHQHSFKVGTAKVNCMVMADQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIVQDGQEAPSNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLHGGRLWCCTGNSIMVMKMNGSLHQELKIEENFKDTSTSFLAFQLLPEEEQLWAACAGRSEVYIWSLKDLAQPPQRVPLEDCSEINCMIRVKKQVWVGSRGLGQGTPKGKIYVIDAERKTVEKELVAHMDTVRTLCSAEDRYVLSGSGREEGKVAIWKGE"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RUS2#B3KRG7-1", 
            "isoform_ac": "B3KRG7-1", 
            "locus": {
                "end_pos": 141188992, 
                "start_pos": 141194230, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000523308", 
                        "id": "ENST00000523308", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000430912", 
                        "id": "ENSP00000430912", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|B3KRG7-1|DEND3_HUMAN Computationally mapped isoform of DENN domain-containing protein 3  OS=Homo sapiens OX=9606 GN=DENND3 PE=1 SV=1 CANONICAL=A2RUS2-1", 
                "length": 248, 
                "sequence": "MVMADQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIVQDGQEAPSNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLHGGRLWCCTGNSIMVMKMNGSLHQELKIEENFKDTSTSFLAFQLLPEEEQLWAACAGRSEVYIWSLKDLAQPPQRVPLEDCSEINCMIRVKKQVWVGSRGLGQGTPKGKIYVIDAERKTVEKELVAHMDTVRTLCSAEDRYVLSGSGREEGKVAIWKGE"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:22898", 
            "resource": "KEGG Pathway", 
            "id": "hsa:22898", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198", 
            "resource": "Reactome", 
            "id": "R-HSA-8876198", 
            "name": "RAB GEFs exchange GTP for GDP on RABs"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RUS2#function", 
            "annotation": "Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RUS2#function", 
                    "id": "A2RUS2", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "A2RT67-1", 
            "protein_name": "DENN domain-containing protein 3.", 
            "sequence": {
                "length": 1274, 
                "sequence": "MAEPAARHLSLPSGLLELCALLGASQDSLRGLEQIAQKRGVKSASSLVPEVLSVFVPPFTTKEDGQVPGASCALGKGRRRSFRKKREKPRMEPWKSHPGDSKGPDSEDVTIPGGVDLLALPQLCFPGCVCVASEPKEDYIHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKSHWEPSVISARCFVPFAVCVVSRFPYYNSLKDCLSCLLTHLKLCKDFEVDNHIKDFAARLSLIPSPPPGPLHLIFNMKPLQVVFPSRADPESPIVDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVPILSGQMLDFVMAPTSFLMGCHLDHFEEVRKEADGLVLIDIDHGSVTCSKSSDDNIDIPDVPLLLAQTFIQRVQSLQLHPDLHLAHLSASTDLNEGRARRRAWQQTLNCKIQHITLQLLVGIFREVKNHLNYEHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKARLNGRMDAFARMDLDTQSEEDRIDRMLISPRRPTVEKMASRKASPLHITHRRMVVSMPNLQDISLPELPPRNSSLRIMDTSNCRSSSPVLKVTPKSTYMFKIPDIHFPLESQCVQAYYTDFVTLLSKAMALLGPGDSLLLARYFYLRGLLHLMQGQLLSALLDFQNLYKTDIGIFPADLVKRTVESMSASERAQAERTPELRRLITEVFDKHGEAPKADDAVKNFELPKKHMQLNDFVKRVQESGIVKDAVIIHRLFDALTFGHEKQIDPETFRDFYTCWKETEAEAQEVSLPALLMEHLDKNECVYKLSSSVKTNRGVGKIAMTQKRLFLLTEGRPGYVEIATFRNIEEVKNSTVAFLLLRIPTLKIKTVAKKEVFEANLKSECDLWHLMVKEMWAGKQLADDHKDPQYVQQALTNVLLMDAVVGTLQSPSAIHAASKLAYFDNMKKKSPMAVPKTTSETLKHKINPSAGETAPQAIEVLLYTPGRLDPAEKVEDAHPKLWCALNEGKVVVFDASSWTVHQHCFKVGSSKVNCMVMAEHNQVWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVHNGKKPSEIYSCSLDGTVIAWNVSTLRVISRFQLSYGDLLSISLHNDRIWCCTVHKILVVTPQGFVRQELKHPKDASFLAFQLLPEEQQLWAASTGVSELYMWSLKDLDQPPQKTYLQDCSEVTCMIRVKRQIWVGGRGLSQGKTRGKIYVMDVEKVTVEKELVAHLDTVRTLCSAEDRYVLSGAGQEEGKIAIWKVE"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/28254", 
                    "id": "28254", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "D4A2H4-1", 
            "protein_name": "DENN domain-containing 3.", 
            "sequence": {
                "length": 1278, 
                "sequence": "MAEPSARHLSLPSGLLELCALLGASQDSLRGLEQIAQKRGVNGASSLVPEVLSVFVPPFTTKEDGQVVGASCTLSKGRRRSFRKKREKPRMESWKSHPGDSKGPDSEDVTIPGGVDLLALPQLCFPGGVCVASEPKEDYIHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKSHWEPSMSSARRFVPFAVCVVSRFPYYNSLKDCLSCLLTHLKLCKDFEVDNHIKDFAARLSLIPSPPPGPLHLIFNMKPLQVVFPSRADPESPIIDLDLHLPLLCFRPEKVLQILTCILTEQRMVFFSSDWALLTLMAECFVAYVHPLQWQHTFVPILSGQMLDFVMAPTSFLMGCHLDHFEEVRKEADGLVLIDIDLGSVTCSKSSDEDVDIPDVPLLLAQAFIQRVQSLQLHPDLHLAHLSASTDLNEGRARRRAWQQALNCKIQHITLQLLVGIFREVKNHLNYEHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKARLNGRMDAFARMDLDTQSEEDRIDRMLISPRRPTVEKMASRKASPLNIAHRRMVVSMPNLQDISLPELPPRNSSLRIMDTSSCKSSSPVLKVTPKSTYTFKIPEIHFPLVSQCVQAYFTDLVTLLSKAMALLGPGDSLLLARYFYLRGLIHLMQGQLLNALLDFQSLYKTDIRIFPADLVKGMVDSMSASERAQAERTPELRRLITEVFDKQGEAPKVDDAVKNFELPKKHMQLNDFVKRVQESGIVKDTTIIHRLFDALTVGHEKQIDPETFRDFYTCWKETEAEAQEVSLPALLVDHLDRNECVYKLSSSVKTNRGVGKIAMTQKRLFLLPEGRPSYVEIATFRNIEEVKSTTVAFLLLKIPTLKIKTVAKKEVFEANLKSECDLWHLMVKEMWAGKKLADDHKDPQYVQQALTNVLLMDAVVGTLQSSGAIYAASKLAYFDKMKNELPMAVPKTTSETLKHKINPSAGETAPQAIEVLLYTPGRLDPAEKVEDAHPKLWCALNEGKVVVFDASSWTIHQHCFKVGSSKVNCMVMAEHSQVWVGSEDSVIYIINVHSMSCNKQLTDHRSAVTGLAVPSGKKPSAVYSCSLDGTVLAWNVSTLRVISRFQLQHGDLMSISLHNDRVFCCTARSILVVTLQGFVRQELRIQPSEEPSASFLAIQLLPEEQQLWVACTGVSELYIWSLKDLGQPPQKTHLQDCTEVTCMIRVKRQIWVGGRGLSQGKTRGKIYVMDVEKVTLEKELVAHSDTVRTLCSAEDRYVLSGAGGEEGKIAIWKVE"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/28254", 
                    "id": "28254", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }
    ], 
    "refseq": {
        "url": "", 
        "ac": "", 
        "name": "DENN domain-containing protein 3 isoform 2; DENN domain-containing protein 3; DENN/MADD domain containing 3.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017112", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RUS2", 
                                "id": "A2RUS2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "Rab guanyl-nucleotide exchange factor activity", 
                        "id": "GO:0017112"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RUS2", 
                                "id": "A2RUS2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytosol", 
                        "id": "GO:0005829"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008333", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RUS2", 
                                "id": "A2RUS2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endosome to lysosome transport", 
                        "id": "GO:0008333"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044257", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RUS2", 
                                "id": "A2RUS2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular protein catabolic process", 
                        "id": "GO:0044257"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 75, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 73
        }, 
        {
            "end_pos": 490, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 488
        }, 
        {
            "end_pos": 509, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 507
        }, 
        {
            "end_pos": 932, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 930
        }, 
        {
            "end_pos": 1019, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 1017
        }, 
        {
            "end_pos": 1060, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 1058
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A2RUS2*", 
            "id": "A2RUS2", 
            "database": "IntAct"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037516", 
            "id": "IPR037516", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", 
            "id": "IPR001680", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", 
            "id": "IPR015943", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017986", 
            "id": "IPR017986", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", 
            "id": "IPR019775", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", 
            "id": "IPR036322", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001194", 
            "id": "IPR001194", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR005112", 
            "id": "IPR005112", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF02141", 
            "id": "PF02141", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055772.2", 
            "id": "NP_055772.2", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198", 
            "id": "R-HSA-8876198", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:22898", 
            "id": "hsa:22898", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000105339", 
            "id": "ENSG00000105339", 
            "database": "Bgee"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2RUS2", 
            "id": "PR_A2RUS2", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/22898", 
            "id": "22898", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=29134", 
            "id": "29134", 
            "database": "HGNC"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A2RUS2", 
            "id": "NX_A2RUS2", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=DENND3", 
            "id": "DENND3", 
            "database": "GeneCards"
        }
    ], 
    "expression_disease": [
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            "trend": "Down", 
            "disease": {
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                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "DOID:10283 / Prostate cancer [PCa]"
            }, 
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            "evidence": [
                {
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                "url": "http://disease-ontology.org/term/DOID:5041", 
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            "evidence": [
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            "evidence": [
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                "url": "http://disease-ontology.org/term/DOID:3907", 
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            "evidence": [
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                "name": "DOID:1781 / Thyroid cancer [Thyca]"
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            "evidence": [
                {
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            "evidence": [
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        "chemical_mass": 135890.0
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        }
    ]
}