{ "uniprot_canonical_ac": "A2APF3-1", "sequence": { "header": "sp|A2APF3-1|CTCFL_MOUSE Isoform 1 of Transcriptional repressor CTCFL OS=Mus musculus OX=10090 GN=Ctcfl PE=1 SV=1 CANONICAL=A2APF3-1", "length": 636, "sequence": "MAAAEVPVPSGYFTQIKEQKLKPGDLEEEKEEDGVQRVEAQEGVVKEVEAENSCLLLEARAPVESDRRILTLQTVHLESQDVHLQGLGWLSVPHSEELSGTVPEAEGILQLPSVLWLDPEPQLSLQHCVTVSIPEELYPPEELQRIHFHLLRENVLMAEENPELTPDLDESTALKKPEEDEKDQLPPQGETDKREERLLLLEMKPKEGKDDEIVLTISHLSLEEQQDPPAANQTSVPGAKAAKPKRRRQTKGKPQSFQCDTCPFTSSKLSTFNRHIKIHSNERPHLCHLCLKAFRTVTLLRNHVNTHTGTRPHKCRDCDMAFVTSGELVRHRRYKHTYEKPFKCSLCKYASVEASKMKRHIRSHTGERPFQCCQCAYASRDSYKLKRHMRTHSGEKPYECPTCHVRFTQSGTMKIHIAQKHGENVPKYECPHCATIIARKSDLRVHLRNLHSQSPEEMKCRYCPAGFHERYALIQHQRTHKNEKKFKCKQCDYACKQERCLKAHMRMHTGEKPFSCLACNKHFRQKQLLTVHLRKYHDPNFVPNLHLCLKCDKRFSRWSNLQRHRKKCDPEHETLAPNKDRRPVTRTQASEGEAGHKEGEPQCPGEQALGHQGEAAGSQSPDHGLTCEIIFNMMDK" }, "uniprot_id": "CTCFL_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "transcriptional repressor CTCFL isoform 2", "CTCF paralog; CTCF-like protein; Transcriptional repressor CTCFL; Brother of the regulator of imprinted sites; BORIS; likely orthologue of H. sapiens CCCTC-binding factor-like protein (CTCFL)" ], "uniprotkb": [ "Transcriptional repressor CTCFL", "CTCF paralog", "CCCTC-binding factor", "Brother of the regulator of imprinted sites", "CTCF-like protein" ] }, "gene": { "refseq": [ "Ctcfl", "Boris" ], "uniprotkb": [ "Ctcfl", "Boris" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APF3", "id": "A2APF3", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Transcriptional repressor CTCFL; CTCF paralog; CCCTC-binding factor; Brother of the regulator of imprinted sites; CTCF-like protein." }, "publication": [ { "title": "Testis-specific transcriptional regulators selectively occupy BORIS-bound CTCF target regions in mouse male germ cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28145452", "journal": "Scientific reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "id": "NP_001074856.1", "database": "RefSeq" } ], "authors": "Rivero-Hinojosa S, Kang S, Lobanenkov VV, Zentner GE", "date": "2017", "pmid": "28145452" }, { "title": "Expression of the CTCFL Gene during Mouse Embryogenesis Causes Growth Retardation, Postnatal Lethality, and Dysregulation of the Transforming Growth Factor beta Pathway.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26169830", "journal": "Molecular and cellular biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "id": "NP_001074856.1", "database": "RefSeq" } ], "authors": "Sati L, Zeiss C, Yekkala K, Demir R, McGrath J", "date": "2015", "pmid": "26169830" }, { "title": "A cell cycle role for the epigenetic factor CTCF-L/BORIS.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22724006", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "id": "NP_001074856.1", "database": "RefSeq" } ], "authors": "Rosa-Garrido M, Ceballos L, Alonso-Lecue P, Abraira C, Delgado MD, Gandarillas A", "date": "2012", "pmid": "22724006" }, { "title": "Integrating role of T antigen, Rb2/p130, CTCF and BORIS in mediating non-canonical endoplasmic reticulum-dependent death pathways triggered by chronic ER stress in mouse medulloblastoma.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22544282", "journal": "Cell cycle (Georgetown, Tex.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "id": "NP_001074856.1", "database": "RefSeq" } ], "authors": "Macaluso M, Caracciolo V, Rizzo V, Sun A, Montanari M, Russo G, Bellipanni G, Khalili K, Giordano A", "date": "2012", "pmid": "22544282" }, { "title": "DNA damage-induced upregulation of miR-709 in the germline downregulates BORIS to counteract aberrant DNA hypomethylation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19029807", "journal": "Cell cycle (Georgetown, Tex.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "id": "NP_001074856.1", "database": "RefSeq" } ], "authors": "Tamminga J, Kathiria P, Koturbash I, Kovalchuk O", "date": "2008", "pmid": "19029807" }, { "title": "BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18765639", "journal": "Molecular and cellular biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "id": "NP_001074856.1", "database": "RefSeq" } ], "authors": "Nguyen P, Bar-Sela G, Sun L, Bisht KS, Cui H, Kohn E, Feinberg AP, Gius D", "date": "2008", "pmid": "18765639" }, { "title": "CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18632606", "journal": "Cancer research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "id": "NP_001074856.1", "database": "RefSeq" } ], "authors": "Nguyen P, Cui H, Bisht KS, Sun L, Patel K, Lee RS, Kugoh H, Oshimura M, Feinberg AP, Gius D", "date": "2008", "pmid": "18632606" }, { "title": "The testis-specific factor CTCFL cooperates with the protein methyltransferase PRMT7 in H19 imprinting control region methylation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17048991", "journal": "PLoS biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "id": "NP_001074856.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2APF3/publications", "id": "A2APF3", "database": "UniProtKB" } ], "authors": "Jelinic P, Stehle JC, Shaw P", "date": "2006", "pmid": "17048991" }, { "title": "BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12011441", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APF3/publications", "id": "A2APF3", "database": "UniProtKB" } ], "authors": "Rasko J.E.J., Zhuang Z., Feinberg A.P., Pugacheva E., Quitschke W.W., Vostrov A.A., Cui H., Morse H.C. III, Larsson E., Pack S.D., Renkawitz R., Breen J.J., Chernukhin I., Docquier F.M., Kanduri C., Kistler M., Klenova E.M., Lobanenkov V.V., Loukinov D.I., Mannan P., Moon H., Niemitz E.L., Ohlsson R., Vatolin S.", "date": "2002", "pmid": "12011441" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2APF3#A2APF3-1", "isoform_ac": "A2APF3-1", "locus": { "end_pos": 173094670, "start_pos": 173118788, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000094287", "id": "ENSMUST00000094287", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000091845", "id": "ENSMUSP00000091845", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2APF3-1|CTCFL_MOUSE Isoform 1 of Transcriptional repressor CTCFL OS=Mus musculus OX=10090 GN=Ctcfl PE=1 SV=1 CANONICAL=A2APF3-1", "length": 636, "sequence": "MAAAEVPVPSGYFTQIKEQKLKPGDLEEEKEEDGVQRVEAQEGVVKEVEAENSCLLLEARAPVESDRRILTLQTVHLESQDVHLQGLGWLSVPHSEELSGTVPEAEGILQLPSVLWLDPEPQLSLQHCVTVSIPEELYPPEELQRIHFHLLRENVLMAEENPELTPDLDESTALKKPEEDEKDQLPPQGETDKREERLLLLEMKPKEGKDDEIVLTISHLSLEEQQDPPAANQTSVPGAKAAKPKRRRQTKGKPQSFQCDTCPFTSSKLSTFNRHIKIHSNERPHLCHLCLKAFRTVTLLRNHVNTHTGTRPHKCRDCDMAFVTSGELVRHRRYKHTYEKPFKCSLCKYASVEASKMKRHIRSHTGERPFQCCQCAYASRDSYKLKRHMRTHSGEKPYECPTCHVRFTQSGTMKIHIAQKHGENVPKYECPHCATIIARKSDLRVHLRNLHSQSPEEMKCRYCPAGFHERYALIQHQRTHKNEKKFKCKQCDYACKQERCLKAHMRMHTGEKPFSCLACNKHFRQKQLLTVHLRKYHDPNFVPNLHLCLKCDKRFSRWSNLQRHRKKCDPEHETLAPNKDRRPVTRTQASEGEAGHKEGEPQCPGEQALGHQGEAAGSQSPDHGLTCEIIFNMMDK" } }, { "url": "https://www.uniprot.org/uniprot/A2APF3#A2APF3-2", "isoform_ac": "A2APF3-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A2APF3-2|CTCFL_MOUSE Isoform 2 of Transcriptional repressor CTCFL OS=Mus musculus OX=10090 GN=Ctcfl PE=1 SV=1 CANONICAL=A2APF3-1", "length": 646, "sequence": "MAAAEVPVPSGYFTQIKEQKLKPGDLEEEKEEDGVQRVEAQEGVVKEVEAENSCLLLEARAPVESDRRILTLQTVHLESQDVHLQGLGWLSVPHSEELSGTVPEAEGILQLPSVLWLDPEPQLSLQHCVTVSIPEELYPPEELQRIHFHLLRENVLMAEENPELTPDLDESTALKKPEEDEKDQLPPQGETDKREERLLLLEMKPKEGKDDEIVLTISHLSLEEQQDPPAANQTSVPGAKAAKPKRRRQTKGKPQSFQCDTCPFTSSKLSTFNRHIKIHSNERPHLCHLCLKAFRTVTLLRNHVNTHTGTRPHKCRDCDMAFVTSGELVRHRRYKHTYEKPFKCSLCKYASVEASKMKRHIRSHTGERPFQCCQCAYASRDSYKLKRHMRTHSGEKPYECPTCHVRFTQSGTMKIHIAQKHGENVPKYECPHCATIIARKSDLRVHLRNLHSQSPEEMKCRYCPAGFHERYALIQHQRTHKNEKKFKCKQCDYACKQERCLKAHMRMHTGEKPFSCLACNKHFRQKQLLTVHLRKYHDPNFVPNLHLCLKCDKRFSRWSNLQRHRKKCDPEHETLAPNKDRRPVTRTQASEGEAGHKEDVATQESATSGEPQCPGEQALGHQGEAAGSQSPDHGLTCEIIFNMMDK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:664799", "resource": "KEGG Pathway", "id": "mmu:664799", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2APF3#function", "annotation": "Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APF3#function", "id": "A2APF3", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "annotation": "CTCF and BORIS cooperate with additional Testis-specific transcriptional regulators to regulate gene expression in developing male gametes. Erratum:[Sci Rep. 2017 Aug 04;7:46891. PMID: 28776597] Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "id": "NP_001074856.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "annotation": "The TGFB pathway as most affected by embryonic Ctcfl expression.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "id": "NP_001074856.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "annotation": "Rb2 coimmunolocalizes with the chromatin insulator CCCTC-binding factor (CTCF) and BORIS in T-antigen-positive but not in T-antigen-negative cells.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "id": "NP_001074856.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "annotation": "Down-regulation of endogenous BORIS by specific shRNAs inhibited both RNA transcription and cell cycle progression. The results altogether suggest a role for BORIS in coordinating S phase events with mitosis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "id": "NP_001074856.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "annotation": "DNA damage-induced and ATR/Rfx1-mediated increase of miR-709 expression in exposed testes may be a protective mechanism that effectively decreases a cellular level of BORIS to prevent massive aberrant erasure of DNA methylation after radiation exposure.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "id": "NP_001074856.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "annotation": "CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "id": "NP_001074856.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "annotation": "CTCFL and PRMT7 may play a role in male germline imprinted gene methylation.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "id": "NP_001074856.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q8NI51-1", "protein_name": "Transcriptional repressor CTCFL; testis antigen 27; CT27; CTCF paralog; CCCTC-binding factor; Brother of the regulator of imprinted sites; CTCF-like protein; Zinc finger protein CTCF-T.", "sequence": { "length": 663, "sequence": "MAATEISVLSEQFTKIKELELMPEKGLKEEEKDGVCREKDHRSPSELEAERTSGAFQDSVLEEEVELVLAPSEESEKYILTLQTVHFTSEAVELQDMSLLSIQQQEGVQVVVQQPGPGLLWLEEGPRQSLQQCVAISIQQELYSPQEMEVLQFHALEENVMVASEDSKLAVSLAETTGLIKLEEEQEKNQLLAERTKEQLFFVETMSGDERSDEIVLTVSNSNVEEQEDQPTAGQADAEKAKSTKNQRKTKGAKGTFHCDVCMFTSSRMSSFNRHMKTHTSEKPHLCHLCLKTFRTVTLLRNHVNTHTGTRPYKCNDCNMAFVTSGELVRHRRYKHTHEKPFKCSMCKYASVEASKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHSGEKPYECHICHTRFTQSGTMKIHILQKHGENVPKYQCPHCATIIARKSDLRVHMRNLHAYSAAELKCRYCSAVFHERYALIQHQKTHKNEKRFKCKHCSYACKQERHMTAHIRTHTGEKPFTCLSCNKCFRQKQLLNAHFRKYHDANFIPTVYKCSKCGKGFSRWINLHRHSEKCGSGEAKSAASGKGRRTRKRKQTILKEATKGQKEAAKGWKEAANGDEAAAEEASTTKGEQFPGEMFPVACRETTARVKEEVDEGVTCEMLLNTMDK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/46476", "id": "46476", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "D3ZQ48-1", "protein_name": "CCCTC-binding factor-like.", "sequence": { "length": 635, "sequence": "MAAAEVPVASGHFTQIKEQKLKPGDLEEEKEEGGVQRGEAQEGAVEEAEAEPQELPSRAPVESDRRILTLQTLHLTSQDVHLQGLGWLSVPHSEELSMTVPQAESILQLPSVLWLDPEPPLSLQHCVTVSIPEELYPPEMLELRHFHLLRENVPEDDEENQESTSNLEESTAPKKPEEDEKDQLLPQGGTDKKEERFLFVEMKPREGKDEIVLTISHLSLEEQQDPPAAKHTSAPGAKAAKPKPQRQTKGRPRTFQCDTCPFTSSKLSTFNRHIKIHSDERPHLCHLCLKSFRTVTLLRNHVNTHTGTRPYKCGDCDMAFVTSGELVRHRRYKHTHEKPFKCSLCKYASVEASKLKRHIRSHTGERPFQCSQCAYASKDTYKLKRHMRTHSGEKPYECPTCHARFTQSGTMKIHIAQKHGENVPKHECPHCATIIARKSDLRVHLRNLHGHSPEEIKCRYCPAAFHERYALLQHQRTHKNEKKFKCKQCDYACKQERCLTAHMRTHTGERPFSCLTCNKHFRQKQLLTVHLRKYHDPSFVPSVHLCLKCGKGFSRWSNLQRHRKKCDPEHEKSAPSRNGRPVTRAQASEEGAEHDKGEPRPPEEQALGHQGESAAGSPSPDQGLTCEMIFNMMDK" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2APF3/", "id": "A2APF3", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "ac": "NP_001074856.1", "name": "transcriptional repressor CTCFL isoform 2; CTCF paralog; CTCF-like protein; Transcriptional repressor CTCFL; Brother of the regulator of imprinted sites; BORIS; likely orthologue of H. sapiens CCCTC-binding factor-like protein (CTCFL).", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APF3", "id": "A2APF3", "database": "UniProtKB" } ], "name": "histone binding", "id": "GO:0042393" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APF3", "id": "A2APF3", "database": "UniProtKB" } ], "name": "sequence-specific DNA binding", "id": "GO:0043565" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APF3", "id": "A2APF3", "database": "UniProtKB" } ], "name": "DNA binding", "id": "GO:0003677" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APF3", "id": "A2APF3", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APF3", "id": "A2APF3", "database": "UniProtKB" } ], "name": "RNA polymerase II proximal promoter sequence-specific DNA binding", "id": "GO:0000978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044212", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APF3", "id": "A2APF3", "database": "UniProtKB" } ], "name": "transcription regulatory region DNA binding", "id": "GO:0044212" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APF3", "id": "A2APF3", "database": "UniProtKB" } ], "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228" } ], "total": 7, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APF3", "id": "A2APF3", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APF3", "id": "A2APF3", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016571", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APF3", "id": "A2APF3", "database": "UniProtKB" } ], "name": "histone methylation", "id": "GO:0016571" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006349", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APF3", "id": "A2APF3", "database": "UniProtKB" } ], "name": "regulation of gene expression by genetic imprinting", "id": "GO:0006349" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043046", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APF3", "id": "A2APF3", "database": "UniProtKB" } ], "name": "DNA methylation involved in gamete generation", "id": "GO:0043046" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APF3", "id": "A2APF3", "database": "UniProtKB" } ], "name": "positive regulation of gene expression", "id": "GO:0010628" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APF3", "id": "A2APF3", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APF3", "id": "A2APF3", "database": "UniProtKB" } ], "name": "positive regulation of transcription, DNA-templated", "id": "GO:0045893" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051569", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APF3", "id": "A2APF3", "database": "UniProtKB" } ], "name": "regulation of histone H3-K4 methylation", "id": "GO:0051569" } ], "total": 7, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 234, "annotation": "n_glycosylation_sequon", "start_pos": 232 } ], "crossref": [ { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2APF3*", "id": "A2APF3", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "id": "IPR013087", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "id": "IPR036236", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00096", "id": "PF00096", "database": "Pfam" }, { "url": "http://www.informatics.jax.org/marker/MGI:3652571", "id": "3652571", "database": "MGI" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856.1", "id": "NP_001074856.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:664799", "id": "mmu:664799", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000070495", "id": "ENSMUSG00000070495", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/MKCRYCP/", "id": "MKCRYCP", "database": "OMA" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2APF3", "id": "PR_A2APF3", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/664799", "id": "664799", "database": "GeneID" } ], "expression_disease": [], "uniprot_ac": "A2APF3", "disease": [], "mass": { "monoisotopic_mass": 73108.0, "chemical_mass": 73108.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2APF3", "name": "Ctcfl; Boris.", "locus": { "end_pos": 173093609, "start_pos": 173119525, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000070495", "id": "ENSMUSG00000070495", "database": "Ensembl Gene" } ] } } ] }