{
    "uniprot_canonical_ac": "A2ACT7-1", 
    "sequence": {
        "header": "tr|A2ACT7-1|A2ACT7_MOUSE Isoform 1 of Collagen, type IX, alpha 3  OS=Mus musculus OX=10090 GN=Col9a3 PE=1 SV=1 CANONICAL=A2ACT7-1", 
        "length": 680, 
        "sequence": "MTGAPALALLLLGQLLTATSAQKVGPRGPPGPQGPPGKPGKDGIDGEAGPPGLPGLPGPKGTSGKPGKPGEAGLPGLPGVDGLTGRDGPAGPKGAPGERGSLGPPGPPGLGGKGLPGPPGEAGVSGLPGGIGLRGPPGPSGLPGLPGLPGPPGPPGNPGVLPEGATDLQCPAICPPGPPGPPGMPGFKGPTGYKGEQGEVGKDGEKGSPGPPGPPGIPGTVGLQGPRGLRGLPGPLGPPGDRGPIGFRGPPGTPGAPGKVGDRGERGPEGFRGPKGDLGRPGPKGIPGMAGPGGEPGMPGKDGKDGVPGLDGEKGEAGRNGGQGEKGPNGLPGLPGRAGSKGEKGEPGRTGELGEAGPSGEPGIPGDVGVPGERGEAGHRGSVGALGPQGPPGAPGIRGFQGQKGSTGDPGLPGPQGLRGDVGDRGPGGATGPKGDQGIAGSDGLPGDKGELGPNGPVGQKGESGSRGELGPKGIQGPNGTSGVQGVPGPPGPLGLQGVQGVPGITGKPGVPGKEASEQRIRELCGGMISEQIAQLAAHLRKPLAPGSIGRPGPAGPPGPPGPPGSIGHPGARGPPGYRGPTGELGDPGPRGSQGDRGDKGATGAGLDGPAGDQGYQGPQGVPGISKDGRDGAHGEPGLPGDPGLPGAAGAQGTPGICDTSACQGAVLGGGGEKSGPRSS"
    }, 
    "uniprot_id": "A2ACT7_MOUSE", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "collagen alpha-3(IX) chain precursor", 
                "procollagen, type IX, alpha 3"
            ], 
            "uniprotkb": [
                "Collagen, type IX, alpha 3", 
                "Procollagen, type IX, alpha 3"
            ]
        }, 
        "gene": {
            "refseq": [
                "Col9a3", 
                "AV006866"
            ], 
            "uniprotkb": [
                "Col9a3", 
                "mCG_140084", 
                "AV006866"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2ACT7", 
                    "id": "A2ACT7", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "recommendedname": {
        "full": "Collagen, type IX, alpha 3; Procollagen, type IX, alpha 3."
    }, 
    "publication": [
        {
            "title": "Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/28705898", 
            "journal": "Development (Cambridge, England)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034066.2", 
                    "id": "NP_034066.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Rutledge EA, Benazet JD, McMahon AP", 
            "date": "2017", 
            "pmid": "28705898"
        }, 
        {
            "title": "Early changes in morphology, bone mineral density and matrix composition of vertebrae lead to disc degeneration in aged collagen IX -/- mice.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/26429145", 
            "journal": "Matrix biology : journal of the International Society for Matrix Biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034066.2", 
                    "id": "NP_034066.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Kamper M, Hamann N, Prein C, Clausen-Schaumann H, Farkas Z, Aszodi A, Niehoff A, Paulsson M, Zaucke F", 
            "date": "2016", 
            "pmid": "26429145"
        }, 
        {
            "title": "Comparative proteomic analysis of normal and collagen IX null mouse cartilage reveals altered extracellular matrix composition and novel components of the collagen IX interactome.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/23530037", 
            "journal": "The Journal of biological chemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034066.2", 
                    "id": "NP_034066.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Brachvogel B, Zaucke F, Dave K, Norris EL, Stermann J, Dayakli M, Koch M, Gorman JJ, Bateman JF, Wilson R", 
            "date": "2013", 
            "pmid": "23530037"
        }, 
        {
            "title": "BRK/Sik expression in the gastrointestinal tract and in colon tumors.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/10430081", 
            "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034066.2", 
                    "id": "NP_034066.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Llor X, Serfas MS, Bie W, Vasioukhin V, Polonskaia M, Derry J, Abbott CM, Tyner AL", 
            "date": "1999", 
            "pmid": "10430081"
        }, 
        {
            "title": "Developmental regulation of mRNA species for types II, IX and XI collagens during mouse embryogenesis.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/9164858", 
            "journal": "The Biochemical journal", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034066.2", 
                    "id": "NP_034066.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Perala M, Savontaus M, Metsaranta M, Vuorio E", 
            "date": "1997", 
            "pmid": "9164858"
        }, 
        {
            "title": "The complete primary structure of the long form of mouse alpha 1(IX) collagen chain and its expression during limb development.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/8305476", 
            "journal": "Biochimica et biophysica acta", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034066.2", 
                    "id": "NP_034066.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Abe N, Yoshioka H, Inoue H, Ninomiya Y", 
            "date": "1994", 
            "pmid": "8305476"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ACT7#A2ACT7-1", 
            "isoform_ac": "A2ACT7-1", 
            "locus": {
                "end_pos": 180598260, 
                "start_pos": 180621417, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000132527", 
                        "id": "ENSMUST00000132527", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000128718", 
                        "id": "ENSMUSP00000128718", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A2ACT7-1|A2ACT7_MOUSE Isoform 1 of Collagen, type IX, alpha 3  OS=Mus musculus OX=10090 GN=Col9a3 PE=1 SV=1 CANONICAL=A2ACT7-1", 
                "length": 680, 
                "sequence": "MTGAPALALLLLGQLLTATSAQKVGPRGPPGPQGPPGKPGKDGIDGEAGPPGLPGLPGPKGTSGKPGKPGEAGLPGLPGVDGLTGRDGPAGPKGAPGERGSLGPPGPPGLGGKGLPGPPGEAGVSGLPGGIGLRGPPGPSGLPGLPGLPGPPGPPGNPGVLPEGATDLQCPAICPPGPPGPPGMPGFKGPTGYKGEQGEVGKDGEKGSPGPPGPPGIPGTVGLQGPRGLRGLPGPLGPPGDRGPIGFRGPPGTPGAPGKVGDRGERGPEGFRGPKGDLGRPGPKGIPGMAGPGGEPGMPGKDGKDGVPGLDGEKGEAGRNGGQGEKGPNGLPGLPGRAGSKGEKGEPGRTGELGEAGPSGEPGIPGDVGVPGERGEAGHRGSVGALGPQGPPGAPGIRGFQGQKGSTGDPGLPGPQGLRGDVGDRGPGGATGPKGDQGIAGSDGLPGDKGELGPNGPVGQKGESGSRGELGPKGIQGPNGTSGVQGVPGPPGPLGLQGVQGVPGITGKPGVPGKEASEQRIRELCGGMISEQIAQLAAHLRKPLAPGSIGRPGPAGPPGPPGPPGSIGHPGARGPPGYRGPTGELGDPGPRGSQGDRGDKGATGAGLDGPAGDQGYQGPQGVPGISKDGRDGAHGEPGLPGDPGLPGAAGAQGTPGICDTSACQGAVLGGGGEKSGPRSS"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:12841", 
            "resource": "KEGG Pathway", 
            "id": "mmu:12841", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2022090", 
            "resource": "Reactome", 
            "id": "R-MMU-2022090", 
            "name": "Assembly of collagen fibrils and other multimeric structures"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8948216", 
            "resource": "Reactome", 
            "id": "R-MMU-8948216", 
            "name": "Collagen chain trimerization"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1650814", 
            "resource": "Reactome", 
            "id": "R-MMU-1650814", 
            "name": "Collagen biosynthesis and modifying enzymes"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-216083", 
            "resource": "Reactome", 
            "id": "R-MMU-216083", 
            "name": "Integrin cell surface interactions"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3000178", 
            "resource": "Reactome", 
            "id": "R-MMU-3000178", 
            "name": "ECM proteoglycans"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-419037", 
            "resource": "Reactome", 
            "id": "R-MMU-419037", 
            "name": "NCAM1 interactions"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-186797", 
            "resource": "Reactome", 
            "id": "R-MMU-186797", 
            "name": "Signaling by PDGF"
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034066.2", 
            "annotation": "Results show that absence of Col IX induces early developmental, structural and biomechanical alterations in both vertebral body and intervertebral disc which eventually cause severe degenerative changes in the aging spine.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034066.2", 
                    "id": "NP_034066.2", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZX71-1", 
            "protein_name": "Collagen type IX alpha 3 chain.", 
            "sequence": {
                "length": 680, 
                "sequence": "MTGAPALALLLLGQLLTATSAQKVGPRGPPGPQGPPGKPGKDGIDGEAGPPGLPGPPGPKGTSGKPGKPGEAGLPGLPGVDGLTGRDGPAGPKGAPGERGSLGPPGPPGLGGKGLPGPPGEAGVSGLPGGIGLRGPPGPSGLPGLPGPPGPPGPPGNPGVLPEGATDLQCPAICPPGPPGPPGMPGFKGPTGYKGEQGEVGKDGEKGNPGPPGPPGIPGTVGLQGPRGLQGLPGPLGPPGDRGPIGFRGPPGIPGAPGKAGDRGDRGPEGFRGPKGDLGRPGPKGIPGVAGPGGEPGMPGKDGKDGVPGLDGEKGEAGRTGAPGEKGPNGLPGLPGRAGSKGEKGEVGRTGELGEAGPSGEPGIPGDVGVPGERGEAGHRGSVGALGPQGPPGAPGIRGFQGQKGSIGDPGLPGPQGLRGDVGDRGPGGATGPKGDQGIAGSDGLPGDKGELGPNGPVGQKGESGSRGELGPKGIQGPNGTSGVQGVPGPPGPLGFQGVQGVPGITGKPGVPGKEASEQRIRELCGGMISEQIAQLAAHLRKPLAPGSIGRPGPAGPPGPPGPPGSIGHPGARGPPGYRGPTGELGDPGPRGSQGDRGDKGAIGVGLDGPAGDQGYRGPQGVPGISKDGRDGAHGEPGLPGDPGLPGAAGAQGTPGICDTSACQGAVLGGGGEKSGPRSS"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/20438", 
                    "id": "20438", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q14050-1", 
            "protein_name": "Collagen alpha-3(IX) chain.", 
            "sequence": {
                "length": 684, 
                "sequence": "MAGPRACAPLLLLLLLGELLAAAGAQRVGLPGPPGPPGPPGKPGQDGIDGEAGPPGLPGPPGPKGAPGKPGKPGEAGLPGLPGVDGLTGRDGPPGPKGAPGERGSLGPPGPPGLGGKGLPGPPGEAGVSGPPGGIGLRGPPGPSGLPGLPGPPGPPGPPGHPGVLPEGATDLQCPSICPPGPPGPPGMPGFKGPTGYKGEQGEVGKDGEKGDPGPPGPAGLPGSVGLQGPRGLRGLPGPLGPPGDRGPIGFRGPPGIPGAPGKAGDRGERGPEGFRGPKGDLGRPGPKGTPGVAGPSGEPGMPGKDGQNGVPGLDGQKGEAGRNGAPGEKGPNGLPGLPGRAGSKGEKGERGRAGELGEAGPSGEPGVPGDAGMPGERGEAGHRGSAGALGPQGPPGAPGVRGFQGQKGSMGDPGLPGPQGLRGDVGDRGPGGAAGPKGDQGIAGSDGLPGDKGELGPSGLVGPKGESGSRGELGPKGTQGPNGTSGVQGVPGPPGPLGLQGVPGVPGITGKPGVPGKEASEQRIRELCGGMISEQIAQLAAHLRKPLAPGSIGRPGPAGPPGPPGPPGSIGHPGARGPPGYRGPTGELGDPGPRGNQGDRGDKGAAGAGLDGPEGDQGPQGPQGVPGTSKDGQDGAPGEPGPPGDPGLPGAIGAQGTPGICDTSACQGAVLGGVGEKSGSRSS"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/20438", 
                    "id": "20438", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034066.2", 
        "ac": "NP_034066.2", 
        "name": "collagen alpha-3(IX) chain precursor; procollagen, type IX, alpha 3.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005201", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ACT7", 
                                "id": "A2ACT7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular matrix structural constituent", 
                        "id": "GO:0005201"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ACT7", 
                                "id": "A2ACT7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular space", 
                        "id": "GO:0005615"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ACT7", 
                                "id": "A2ACT7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular matrix", 
                        "id": "GO:0031012"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062023", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ACT7", 
                                "id": "A2ACT7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "collagen-containing extracellular matrix", 
                        "id": "GO:0062023"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005594", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ACT7", 
                                "id": "A2ACT7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "collagen type IX trimer", 
                        "id": "GO:0005594"
                    }
                ], 
                "total": 4, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ACT7", 
                                "id": "A2ACT7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular matrix organization", 
                        "id": "GO:0030198"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008584", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ACT7", 
                                "id": "A2ACT7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "male gonad development", 
                        "id": "GO:0008584"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008585", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ACT7", 
                                "id": "A2ACT7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "female gonad development", 
                        "id": "GO:0008585"
                    }
                ], 
                "total": 3, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 481, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 479
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", 
            "id": "IPR008160", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF01391", 
            "id": "PF01391", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:894686", 
            "id": "894686", 
            "database": "MGI"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034066.2", 
            "id": "NP_034066.2", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2022090", 
            "id": "R-MMU-2022090", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8948216", 
            "id": "R-MMU-8948216", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1650814", 
            "id": "R-MMU-1650814", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-216083", 
            "id": "R-MMU-216083", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3000178", 
            "id": "R-MMU-3000178", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-419037", 
            "id": "R-MMU-419037", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-186797", 
            "id": "R-MMU-186797", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:12841", 
            "id": "mmu:12841", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000027570", 
            "id": "ENSMUSG00000027570", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/FKGPTGY/", 
            "id": "FKGPTGY", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/12841", 
            "id": "12841", 
            "database": "GeneID"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A2ACT7", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 63475.0, 
        "chemical_mass": 63475.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ACT7", 
            "name": "Col9a3; mCG_140084; AV006866.", 
            "locus": {
                "end_pos": 180622189, 
                "start_pos": 180597790, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000027570", 
                        "id": "ENSMUSG00000027570", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}