15d14
< "Q8K2W3-1","NP_598866.1","thioredoxin domain-containing protein 11 isoform 2","324",""
17c16
< "P04768-1","NP_036084.2","prolactin family 2, subfamily c, member 4 precursor","224",""
---
> "Q6PG16-1","NP_766093.1","Holliday junction recognition protein","591",""
20a20
> "Q7TNE6-1","NP_001171009.1","double homeobox B-like","350",""
47c47
< "Q3TIX6-1","NP_001277477.1","far upstream element-binding protein 3 isoform b","569",""
---
> "Q3TIX6-1","NP_001028561.2","far upstream element-binding protein 3 isoform a","575",""
51c51
< "Q8JZK6-1","NP_694750.3","putative tripartite motif-containing protein 61","461",""
---
> "Q8JZK6-1","NP_001171022.1","putative tripartite motif-containing protein 61","461",""
58d57
< "Q8C2Y5-1","NP_056608.1","F-box and WD-40 domain protein 14 isoform 1","466",""
61d59
< "Q9ER67-1","NP_109625.1","melanoma-associated antigen D2","616",""
63d60
< "A2ANF5-1","NP_001158156.1","protein FAM104B isoform a","204",""
73a71
> "Q6DIC6-1","NP_001002272.1","trophinin isoform 1","2087",""
79a78
> "Q9ER67-1","NP_001186175.1","melanoma-associated antigen D2","616",""
81d79
< "Q6DIC6-1","NP_001277699.1","trophinin isoform 1","2087",""
90a89
> "Q8JZX6-1","NP_001191170.1","dendritic cell inhibitory receptor 3","237",""
100d98
< "Q8JZX6-1","NP_694877.2","dendritic cell inhibitory receptor 3","237",""
103a102
> "A2ANF5-1","NP_001158155.1","protein FAM104B isoform a","204",""
105d103
< "Q9D4Y3-1","NP_083479.1","reproductive homeobox 2A isoform 1","191",""
109a108
> "D2XZ31-1","NP_001242995.1","androgen-binding protein precursor","93",""
110a110
> "A2AFK4-1","NP_001076797.1","mitochondrial ribosome-associated GTPase 2","405",""
117d116
< "D3YZG3-1","NP_001160621.1","vomeronasal 1 receptor Vmn1r140","307",""
123d121
< "A2BEI6-1","NP_001171049.1","uncharacterized protein LOC667780","360","This gene belongs to a family of related genes tandemly arranged in two clusters on chromosome 4. This family, which appears to be mouse-specific and composed of multiple highly similar members, is supported by limited transcript data. Members of the family maintain an intact open reading frame although the encoded protein has no known function. This gene is supported by alignment of transcripts. [provided by RefSeq, Mar 2013]. "
134a133
> "D3YTY1-1","NP_001160225.1","vomeronasal 1 receptor 155","307",""
135a135
> "Q8BS54-1","NP_001272816.1","zinc finger MYM-type protein 6 isoform b","1157",""
146a147
> "Q9D4D2-1","NP_001186925.1","melanoma-associated antigen 11-like","429",""
156d156
< "Q8BGF0-1","NP_848852.1","BCSC-1","804",""
162a163
> "F6VWU8-1","NP_001318126.1","zinc finger protein 946 isoform b","523",""
176a178
> "Q6P8K3-1","NP_001257386.1","uncharacterized protein LOC666203","481",""
182d183
< "A6X8J1-1","NP_001160118.1","uncharacterized protein LOC100040867","155",""
198a200
> "Q3KNP5-1","NP_997501.2","vomeronasal 1 receptor, D18","305",""
216a219
> "Q7TSV0-1","NP_001297549.1","zinc finger protein 606 isoform 3","736",""
218a222
> "Q9DCP4-1","NP_001153110.1","uncharacterized protein LOC74088 isoform 2","199",""
225d228
< "O09048-1","NP_034802.1","keratin associated protein 6-1","78",""
228d230
< "E9Q8L6-1","NP_001160220.1","vomeronasal 1 receptor 139","297",""
231a234
> "Q9D4Y3-1","NP_001297432.1","reproductive homeobox 2A isoform 2","183",""
242a246
> "E9PZY4-1","NP_001160110.1","uncharacterized protein LOC100043231","289",""
258a263
> "Q9D7L5-1","NP_081380.2","uncharacterized protein LOC71886 isoform 2","200",""
260a266
> "Q9DA59-1","NP_001156955.1","uncharacterized protein C20orf141 homolog","131",""
277a284
> "E9Q8L6-1","NP_001116154.1","vomeronasal 1 receptor 132","297",""
281a289
> "Q9EPS5-1","NP_001160316.1","vomeronasal 1 receptor 100","307",""
286d293
< "Q8C8K6-1","NP_780392.1","ataxin-7-like protein 2 isoform 2","696",""
290d296
< "A2AWL1-1","NP_899143.2","pramel3 family member","463",""
301d306
< "Q8BNV8-1","NP_848911.2","triggering receptor expressed in myeloid cells 4 isoform a precursor","229",""
306d310
< "Q8CD73-1","NP_001230094.1","interferon zeta-like precursor","182",""
315d318
< "A2A8V7-1","NP_001230068.1","uncharacterized protein LOC100041433","445",""
353d355
< "O70616-1","NP_951015.1","uncharacterized protein LOC236546","171",""
364d365
< "B1AYI3-1","NP_001155082.1","interferon zeta-like precursor","182",""
366d366
< "Q9DAR2-1","NP_083935.3","serine/threonine/tyrosine-interacting-like protein 1 isoform a","321",""
373d372
< "Q3UL33-1","NP_001161265.1","uncharacterized protein LOC100041354 isoform 1","481",""
385c384
< "A2BED8-1","NP_084312.1","uncharacterized protein LOC78092","237",""
---
> "Q3U4L8-1","NP_001295252.1","zinc finger protein 51","781",""
396d394
< "Q8BS54-1","NP_803413.1","zinc finger MYM-type protein 6 isoform a","1249",""
403c401
< "Q9D1F0-1","NP_077132.1","mammalian retrotransposon derived 8b","113",""
---
> "O09048-1","NP_001257416.1","predicted gene 10228","78",""
404a403
> "Q9D3U4-1","NP_001279986.1","predicted gene, 21379","565",""
417d415
< "K7N6B8-1","NP_997430.2","vomeronasal 1 receptor 93","321",""
424c422,423
< "Q9CRB4-1","NP_079861.1","uncharacterized protein LOC66479 isoform 2","147",""
---
> "Q3UT86-1","NP_001030076.1","serine/threonine kinase-like","313",""
> "Q62012-1","NP_001116206.1","ovary testis transcribed","449",""
426d424
< "Q8C9M8-1","NP_780767.1","zinc finger protein 446 isoform 1","523",""
434a433
> "G3X9H3-1","NP_001106202.1","uncharacterized protein LOC112415","648",""
436a436
> "A2BEI6-1","NP_001091447.2","uncharacterized protein LOC545637","360","This gene belongs to a family of related genes tandemly arranged in two clusters on chromosome 4. This family, which appears to be mouse-specific and composed of multiple highly similar members, is supported by limited transcript data. Members of the family maintain an intact open reading frame although the encoded protein has no known function. This gene is supported by transcript alignments. [provided by RefSeq, May 2013]. "
451a452
> "Q3UT53-1","NP_001171035.1","eukaryotic translation initiation factor 1A-like 1","144",""
457a459,460
> "A2CGC2-1","NP_001093113.1","germ cell-less homolog 1 family member","496",""
> "Q8CD73-1","NP_001230095.1","interferon zeta-like precursor","182",""
460a464
> "Q810Y7-1","NP_001156830.1","developmental pluripotency associated 1 precursor","116",""
462a467
> "A2ASP7-1","NP_663532.2","uncharacterized protein C1orf159 homolog precursor","199",""
468a474
> "S4R2V3-1","NP_001268452.1","secretoglobin, family 2B, member 15 precursor","82",""
478a485,486
> "Q9DAR2-1","NP_001276486.1","serine/threonine/tyrosine-interacting-like protein 1 isoform b","217",""
> "Q8C9M8-1","NP_001162034.1","zinc finger protein 446 isoform 3","256",""
483a492
> "D3YTY2-1","NP_001160218.1","vomeronasal 1 receptor 111","306",""
514d522
< "Q810Y7-1","NP_839978.1","developmental pluripotency associated 1 precursor","116",""
519a528
> "Q3UTA8-1","NP_001032325.1","serine/threonine kinase-like","301",""
524a534
> "A2A8C4-1","NP_001107207.1","pramel family member","496",""
541a552
> "Q3V0S8-1","NP_001155900.1","uncharacterized protein LOC69324 isoform 1","276",""
543d553
< "J3QK78-1","NP_001230867.1","uncharacterized protein LOC100041102","481",""
548d557
< "Q62012-1","NP_035152.1","ovary testis transcribed","449",""
550d558
< "Q3KNP5-1","NP_997502.2","vomeronasal 1 receptor, D19","305",""
552d559
< "Q3UT53-1","NP_001171044.1","eukaryotic translation initiation factor 1A-like 3","144",""
570c577
< "A2BH01-1","NP_001156667.1","uncharacterized protein LOC666842","229",""
---
> "Q8K0U8-1","NP_001297557.1","pregnancy specific glycoprotein 16 isoform 1","395",""
574d580
< "Q14AF1-1","NP_001156374.1","transmembrane protein 217","189",""
586d591
< "P83882-1","NP_079865.1","60S ribosomal protein L36a-like","106",""
599c604
< "Q91Z40-1","NP_663520.2","guanylate binding protein 7","638",""
---
> "Q8BNV8-1","NP_001107028.1","triggering receptor expressed in myeloid cells 4 isoform b precursor","160",""
604a610
> "Q8BM11-1","NP_001276676.1","protein-glutamine gamma-glutamyltransferase 6 isoform 2","483",""
608a615
> "D3Z3L3-1","NP_001139479.1","tripartite motif-containing 12C","497",""
612a620
> "A8DUK4-1","NP_001188320.1","hemoglobin, beta adult s chain","147","This gene encodes a beta polypeptide chain found in adult hemoglobin, which consists of a tetramer of two alpha chains and two beta chains, and which functions in the transport of oxygen to various peripheral tissues. This gene is one of a cluster of beta-hemoglobin genes that are distally regulated by a locus control region, and which are organized along the chromosome in the order of their developmental expression. In mouse, two major strain-specific haplotypes of the beta-globin gene cluster are found - a 'single' haplotype found in C57BL/-type strains, which includes two highly similar adult beta-globin genes, beta s and beta t, and a 'diffuse' haplotype found in strains such as BALB/c and 129Sv, which includes two somewhat diverse adult beta-globin genes, beta-major and beta-minor. This gene represents the beta s adult gene found in the 'single' haplotype. Primary chromosome 7 of the mouse reference genome assembly, which is derived from C57BL/6 strain mice, represents the 'single' haplotype, while the 'diffuse' haplotype is represented in the reference genome collection by the BALB/c strain alternate contig, NT_095534.1. [provided by RefSeq, May 2013]. "
630d637
< "Q9EPS5-1","NP_109661.1","vomeronasal 1 receptor, D14","307",""
632a640
> "Q4TU90-1","NP_001171898.1","reproductive homeobox 3E","215",""
651d658
< "Q3UTA8-1","NP_001257423.1","serine/threonine kinase-like","301",""
659a667
> "K9J7G0-1","NP_001160219.1","vomeronasal 1 receptor 135","307",""
662d669
< "Q3V0S8-1","NP_081314.1","uncharacterized protein LOC69324 isoform 2","263",""
664c671
< "Q8C898-1","NP_780428.1","SP140 nuclear body protein family member isoform 1","291",""
---
> "J3QP37-1","NP_001240725.1","small integral membrane protein 22 isoform 1","91",""
675a683
> "A2A7V0-1","NP_001171016.1","zinc finger protein 600","737",""
699d706
< "Q3UH45-1","NP_001276439.1","tectonin beta-propeller repeat-containing protein 2 isoform 1","1423",""
739a747
> "Q8C898-1","NP_001032998.2","SP140 nuclear body protein family member isoform 2","263",""
748d755
< "D3Z3L3-1","NP_783608.3","tripartite motif-containing 12C","497",""
758a766
> "J3QK78-1","NP_001230866.1","uncharacterized protein LOC100041102","481",""
760d767
< "K9J7G0-1","NP_001160227.1","vomeronasal 1 receptor 163","307",""
777d783
< "D3YTY2-1","NP_001160641.1","vomeronasal 1 receptor Vmn1r138","306",""
784a791
> "A0A140LJ87-1","NP_001311480.1","serine/threonine-protein kinase MARK2-like","301",""
785a793
> "Q8BGS5-1","NP_001001447.1","zinc finger and SCAN domain-containing protein 22 isoform a","496",""
789d796
< "F6VWU8-1","NP_932120.1","zinc finger protein 946 isoform b","523",""
792d798
< "K9J724-1","NP_001257542.1","alpha-defensin 5-like precursor","93",""
801d806
< "Q3U4L8-1","NP_033584.3","zinc finger protein 51","781",""
805a811
> "Q8R2C0-1","NP_001161039.1","vomeronasal 1 receptor Vmn1r186","300",""
816d821
< "Q52KH6-1","NP_001020555.2","uncharacterized protein LOC574405","695",""
822a828
> "B2RWR6-1","NP_001257439.1","predicted gene 10256","380",""
824d829
< "E9Q492-1","NP_001156392.1","piggyBac transposable element-derived protein 1 isoform a","415",""
830a836
> "Q8BGF0-1","NP_001186485.1","BCSC-1","804",""
843c849
< "K7N6B7-1","NP_001160633.1","vomeronasal 1 receptor Vmn1r102","321",""
---
> "Q52KH6-1","NP_001020554.1","uncharacterized protein LOC574404","695",""
849d854
< "Q62478-1","NP_033555.1","Xlr-related, meiosis regulated","212",""
855a861
> "Q3UH45-1","NP_001074526.1","tectonin beta-propeller repeat-containing protein 2 isoform 1","1423",""
863d868
< "A2A7V0-1","NP_001171017.1","zinc finger protein 600","737",""
870c875
< "A9Z055-1","NP_001171040.1","histone variant H2al2-like","111",""
---
> "K7N6B7-1","NP_001160632.1","vomeronasal 1 receptor Vmn1r150","321",""
875a881
> "E9PUW9-1","NP_001160222.1","vomeronasal 1 receptor 143","307",""
886d891
< "J3QP37-1","NP_001240731.1","small integral membrane protein 22 isoform 1","91",""
904c909
< "Q8K0U8-1","NP_031702.3","pregnancy specific glycoprotein 16 isoform 2","386",""
---
> "Q14AF1-1","NP_001156373.1","transmembrane protein 217","189",""
907a913
> "Q8BX39-1","NP_001257435.1","predicted gene 2104","182",""
918d923
< "Q9D7L5-1","NP_082257.1","uncharacterized protein LOC71886 isoform 1","217",""
923c928
< "Q9DA59-1","NP_083651.1","uncharacterized protein C20orf141 homolog","131",""
---
> "Q9CRB4-1","NP_001074246.1","uncharacterized protein LOC66479 isoform 1","151",""
944d948
< "A2ASP7-1","NP_796179.1","uncharacterized protein C1orf159 homolog precursor","199",""
948c952
< "Q8R2C0-1","NP_109666.2","vomeronasal 1 receptor, D2","300",""
---
> "O70616-1","NP_001297556.1","uncharacterized protein LOC236546","171",""
952,954d955
< "Q9EPT1-1","NP_109667.1","vomeronasal 1 receptor 63","300",""
< "D3YTY1-1","NP_001160322.1","vomeronasal 1 receptor 165","307",""
< "A2A8C4-1","NP_001107208.1","pramel family member","496",""
962d962
< "A2ART0-1","NP_001158161.1","KRAB box and zinc finger, C2H2 type domain containing protein","554",""
966d965
< "G3X9H3-1","NP_940809.2","uncharacterized protein LOC112415","648",""
976d974
< "E9PUW9-1","NP_001161010.1","vomeronasal 1 receptor, 95","307",""
1014d1011
< "E9PZY4-1","NP_001160113.1","uncharacterized protein LOC100043239","289",""
1020d1016
< "Q8BM11-1","NP_808394.1","protein-glutamine gamma-glutamyltransferase 6 isoform 1","706",""
1021a1018
> "Q810R8-1","NP_001153615.1","predicted gene, 20823","227",""
1028a1026
> "Q8C8K6-1","NP_001276474.1","ataxin-7-like protein 2 isoform 1","754",""
1032d1029
< "Q9D3H4-1","NP_082076.1","keratin associated protein 2-4","131",""
1043a1041
> "A2AWL1-1","NP_001229866.1","pramel3 family member","463",""
1064a1063
> "Q8C2Y5-1","NP_001298088.1","F-box and WD-40 domain protein 14 isoform 2","413",""
1076a1076
> "E9Q492-1","NP_001156391.1","piggyBac transposable element-derived protein 1 isoform a","415",""
1081a1082
> "Q8BJX2-1","NP_001276667.1","uncharacterized protein C20orf96 homolog isoform 1","355",""
1089,1090d1089
< "Q9D4D2-1","NP_001186926.1","melanoma-associated antigen 11-like","429",""
< "Q8BJX2-1","NP_808324.1","uncharacterized protein C20orf96 homolog isoform 2","354",""
1097d1095
< "A2CGC2-1","NP_001229930.1","germ cell-less homolog 1 family member","496",""
1113a1112
> "A2A8V7-1","NP_001230067.1","uncharacterized protein LOC100041433","445",""
1118d1116
< "Q8BGS5-1","NP_001277367.1","zinc finger and SCAN domain-containing protein 22 isoform a","496",""
1121c1119
< "Q9DCP4-1","NP_083023.1","uncharacterized protein LOC74088 isoform 1","223",""
---
> "Q9EPT1-1","NP_001161040.1","vomeronasal 1 receptor Vmn1r187","300",""
1139d1136
< "Q4TU90-1","NP_918952.2","reproductive homeobox 3A","215",""
1149d1145
< "A2AFK4-1","NP_852089.2","mitochondrial ribosome-associated GTPase 2","405",""
1152d1147
< "Q7TSV0-1","NP_080388.2","zinc finger protein 606 isoform 1","794",""
1618d1612
< "Q5I0W6-1","NP_955771.2","methyltransferase like 7A2","244",""
1632d1625
< "O35199-1","NP_033513.1","vomeronasal 2, receptor 89 isoform 2 precursor","507",""
1695a1689
> "Q3UTQ6-1","NP_001039018.1","Kruppel-like zinc finger protein","422",""
1729d1722
< "Q3UTQ6-1","NP_766342.2","Kruppel-like zinc finger protein","422",""
1749a1743
> "Q9DC47-1","NP_001035054.1","zinc finger protein 869","529",""
1867d1860
< "Q9Z116-1","NP_038872.1","zinc finger protein 68 isoform a","606",""
1919a1913
> "Q80ZX2-1","NP_001139352.1","zinc finger protein 790","779",""
1920a1915,1916
> "Q8VI97-1","NP_001153406.1","2'-5' oligoadenylate synthetase 1H isoform 2","239",""
> "A2BH01-1","NP_001119789.1","synaptonemal complex protein 3-like","229",""
1925d1920
< "Q80ZX2-1","NP_666297.2","zinc finger protein 790","779",""
1932a1928
> "Q8BY68-1","NP_001116067.1","purinergic receptor P2Y G-protein coupled 10-like","352",""
1938a1935
> "Q3UWK8-1","NP_001070258.1","serine (or cysteine) peptidase inhibitor, clade B, member 6d","375","This gene is a member of the large Serpin gene family. Many members of this family act as protease inhibitors, and have a conserved structure including a reactive center loop (RCL) that can act as a bait for protease targets. Unlike some members of this large gene family, the protein encoded by this gene is an intracellular protein, and lacks an N-terminal signal peptide sequence. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 13. [provided by RefSeq, Jul 2014]. "
1941d1937
< "Q8BY68-1","NP_780651.1","purinergic receptor P2Y G-protein coupled 10-like","352",""
1950d1945
< "Q8VI97-1","NP_660263.1","2'-5' oligoadenylate synthetase 1H isoform 1","369",""
1977a1973
> "Q3TDV8-1","NP_001139496.1","zinc finger protein 444","331",""
1981a1978
> "A9Z055-1","NP_001106866.1","histone variant H2al2-like","111",""
1998d1994
< "Q3TDV8-1","NP_082592.2","zinc finger protein 444","331",""
2003d1998
< "B2RT54-1","NP_083695.2","apolipoprotein L 7a","418",""
2011,2012d2005
< "Q8C7I4-1","NP_776104.1","apolipoprotein L 9b","310",""
< "J3QMK2-1","NP_001182277.1","BBSome-interacting protein 1","67",""
2041a2035
> "E9Q2I4-1","NP_001156973.1","ELM2 and SANT domain-containing protein 1","1089",""
2051d2044
< "Q8VDU3-1","NP_776147.1","apolipoprotein L 9a","310",""
2063a2057
> "Q8C7I4-1","NP_001162131.1","apolipoprotein L 9b","310",""
2069d2062
< "E9Q2I4-1","NP_001156974.1","ELM2 and SANT domain-containing protein 1","1089",""
2073a2067
> "Q9D5W6-1","NP_001157705.1","solute carrier organic anion transporter family, member 6d1 isoform 2","650",""
2074a2069
> "A6X8J1-1","NP_001160073.1","predicted gene 16430","155",""
2156a2152
> "B2RT54-1","NP_001158112.1","apolipoprotein L 7a","418",""
2162a2159
> "E9Q3R6-1","NP_001158047.1","zinc finger protein 169 isoform a","731",""
2177c2174
< "Q9D5W6-1","NP_081860.1","solute carrier organic anion transporter family, member 6d1 isoform 1","683",""
---
> "G3UW50-1","NP_001165575.1","zinc finger and BTB domain-containing protein 25","439",""
2230a2228
> "Q9QUS9-1","NP_038921.2","regenerating islet-derived 3 delta isoform 1 precursor","175",""
2234d2231
< "Q810R8-1","NP_997045.1","Ssty1 family member","227",""
2238d2234
< "E9Q3R6-1","NP_080726.3","zinc finger protein 169 isoform a","731",""
2272a2269
> "Q3UWL8-1","NP_001103622.1","prefoldin subunit 4 isoform 1","134",""
2280a2278
> "Q9Z116-1","NP_001157269.1","zinc finger protein 68 isoform a","606",""
2288d2285
< "A2ATW2-1","NP_666377.2","olfactory receptor 1506","309","Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. "
2294d2290
< "Q3UT86-1","NP_001188293.1","serine/threonine kinase-like","313",""
2297a2294
> "K9J724-1","NP_001170993.1","alpha-defensin 5-like precursor","93",""
2300d2296
< "G3UW50-1","NP_082632.2","zinc finger and BTB domain-containing protein 25","439",""
2315d2310
< "Q9D3U4-1","NP_083246.1","RNA binding motif 31, Y-linked","565",""
2320d2314
< "Q9QUS9-1","NP_001155213.1","regenerating islet-derived 3 delta isoform 2 precursor","129",""
2333a2328
> "J3QMK2-1","NP_001182267.1","BBSome-interacting protein 1","67",""
2340d2334
< "Q3UWL8-1","NP_001186831.1","prefoldin subunit 4 isoform 3","130",""
2342a2337
> "Q91ZD5-1","NP_081182.2","cathepsin 3 precursor","332",""
2357d2351
< "Q61635-1","NP_032356.1","interferon gamma inducible protein 47","420",""
2364d2357
< "Q3SXD1-1","NP_001092796.1","ferritin, heavy polypeptide-like 17-like 3","176",""
2370d2362
< "Q7TQX8-1","NP_666374.2","olfactory receptor 1290","312","Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. "
2387a2380
> "Q91Z40-1","NP_001076781.1","guanylate binding protein 7","638",""
2445d2437
< "D2XZ31-1","NP_001257471.1","androgen-binding protein-like precursor","93",""
2449d2440
< "A2BE20-1","NP_001229873.1","KRAB box and zinc finger, C2H2 type domain containing protein-like","318",""
2456a2448
> "O35199-1","NP_033512.1","vomeronasal 2, receptor 89 isoform 1 precursor","432",""
2458a2451
> "Q61635-1","NP_001258605.1","interferon gamma inducible protein 47","420",""
2470a2464
> "Q6NZI9-1","NP_001038951.1","zinc finger protein 180 isoform a","655",""
2491d2484
< "Q6NZI9-1","NP_001276570.1","zinc finger protein 180 isoform d","595",""
2492a2486
> "B1AYI3-1","NP_001155080.1","interferon zeta-like precursor","182",""
2502d2495
< "B2RWR6-1","NP_001257440.1","predicted gene 10352","380",""
2515a2509
> "Q7TQX8-1","NP_001265716.1","olfactory receptor 1290","312","Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. "
2529d2522
< "Q91ZD5-1","NP_473433.2","cathepsin 3 precursor","332",""
2536a2530
> "Q9D1U5-1","NP_001294953.1","cutA divalent cation tolerance homolog-like isoform 2","111",""
2538d2531
< "Q3UXL1-1","NP_081858.2","aldo-keto reductase family 1, member C-like isoform 1","322",""
2539a2533
> "Q9JJQ7-1","NP_001280605.1","X-linked lymphocyte-regulated 4B","215",""
2542,2543d2535
< "Q9D1U5-1","NP_084297.1","cutA divalent cation tolerance homolog-like isoform 1","156",""
< "Q920S1-1","NP_694692.1","granzyme N isoform 2 precursor","248",""
2544a2537
> "Q3UXL1-1","NP_001297546.1","aldo-keto reductase family 1, member C-like isoform 2","291",""
2546,2547d2538
< "Q3UWK8-1","NP_001287821.1","serine (or cysteine) peptidase inhibitor, clade B, member 6d","375","This gene is a member of the large Serpin gene family. Many members of this family act as protease inhibitors, and have a conserved structure including a reactive center loop (RCL) that can act as a bait for protease targets. Unlike some members of this large gene family, the protein encoded by this gene is an intracellular protein, and lacks an N-terminal signal peptide sequence. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 13. [provided by RefSeq, Jul 2014]. "
< "Q9JJQ7-1","NP_067340.2","X-linked lymphocyte-regulated 4B","215",""
2561d2551
< "A0A140LJ87-1","NP_001311481.1","predicted gene 4565","301",""
2570d2559
< "Q9DC47-1","NP_851791.1","zinc finger protein 869","529",""
2585a2575
> "Q62478-1","NP_001092817.1","uncharacterized protein LOC100042175","212",""
2626a2617
> "Q8K5B9-1","NP_001136222.1","TGFB-induced factor homeobox 2-like, X-linked 2","231",""
2629c2620,2621
< "C0LLJ0-1","NP_001334460.1","importin subunit alpha-8 isoform 1","520",""
---
> "Q8VDV3-1","NP_001334358.1","guanine nucleotide exchange factor for Rab-3A isoform 2","314",""
> "Q3U6N9-1","NP_001334469.1","UPF0488 protein C8orf33 homolog isoform 1","222",""
2636c2628,2629
< "Q8BIZ1-1","NP_852063.1","ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform 2","426",""
---
> "Q8BFU3-1","NP_001297768.1","RING finger protein 214 isoform 2","513",""
> "Q9D7P9-1","NP_001186142.1","serpin B12","423",""
2644d2636
< "Q5U5Q9-1","NP_035437.1","BRCA1-A complex subunit RAP80 isoform 1","727",""
2646c2638
< "Q9D7P9-1","NP_082247.1","serpin B12","423",""
---
> "Q9CZI9-1","NP_001156411.1","apoptosis-enhancing nuclease isoform 2","298",""
2655d2646
< "Q922J9-1","NP_081655.2","fatty acyl-CoA reductase 1 isoform 1","515",""
2657a2649
> "Q922J9-1","NP_001272760.1","fatty acyl-CoA reductase 1 isoform 2","515",""
2660d2651
< "B7ZMP1-1","NP_796284.1","xaa-Pro aminopeptidase 3 isoform 1","386",""
2662a2654
> "Q0P5X1-1","NP_001157031.1","leucine-rich repeat and IQ domain-containing protein 1 isoform 1","1673",""
2663a2656
> "Q8BIZ1-1","NP_001170868.1","ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform 4","404",""
2675c2668
< "Q8BFQ2-1","NP_848860.1","transmembrane protein 229B","167",""
---
> "Q8BFQ2-1","NP_001163872.1","transmembrane protein 229B","167",""
2687a2681
> "Q791T5-1","NP_001334264.1","mitochondrial carrier homolog 1 isoform 2","372",""
2691d2684
< "Q791T5-1","NP_063933.1","mitochondrial carrier homolog 1 isoform 1","389",""
2693a2687
> "Q2TA57-1","NP_001034734.1","aspartate beta-hydroxylase domain-containing protein 1 isoform 2","109",""
2695d2688
< "Q80WJ1-1","NP_874355.1","gametogenetin isoform 3","137",""
2699d2691
< "Q2TA57-1","NP_001334586.1","aspartate beta-hydroxylase domain-containing protein 1 isoform 1","360",""
2709d2700
< "Q8BKP2-1","NP_663522.2","zinc finger protein 189","608",""
2714d2704
< "Q8BX39-1","NP_780551.1","cytoplasmic polyadenylated homeobox 1","182",""
2720,2721d2709
< "Q80Y32-1","NP_821136.1","HMG domain-containing protein 4 isoform 1","594",""
< "Q3UL53-1","NP_001192203.1","Crx opposite strand transcript 1 isoform c","120",""
2723a2712
> "Q8BKP2-1","NP_001276830.1","zinc finger protein 189","608",""
2736a2726
> "Q3UL53-1","NP_001028810.1","Crx opposite strand transcript 1 isoform a","246",""
2745a2736
> "Q80Y32-1","NP_001303682.1","HMG domain-containing protein 4 isoform 2","485",""
2761d2751
< "Q6P8K3-1","NP_941069.1","uncharacterized protein LOC381724","481",""
2767a2758
> "Q5FWC3-1","NP_001334364.1","membrane-spanning 4-domains subfamily A member 13 isoform 2","174",""
2772c2763
< "Q8BHA3-1","NP_083821.1","D-aminoacyl-tRNA deacylase 2 isoform 2","168",""
---
> "Q8BHA3-1","NP_001334333.1","D-aminoacyl-tRNA deacylase 2 isoform 1","166",""
2779a2771
> "Q8BR26-1","NP_001334470.1","interferon-induced transmembrane protein 10 isoform 1","201",""
2781c2773
< "Q8VE42-1","NP_062657.2","ankyrin repeat domain-containing protein 49","238",""
---
> "Q9D300-1","NP_001334391.1","ras-GEF domain-containing family member 1C isoform 1","469",""
2783a2776,2780
> "Q9CRA9-1","NP_001334442.1","FGFR1 oncogene partner 2 homolog isoform 2","215",""
> "Q8C5P5-1","NP_001334392.1","5'-nucleotidase domain-containing protein 1 isoform 2","242",""
> "Q6PFX7-1","NP_001334434.1","neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform 2","832",""
> "Q8R035-1","NP_001334574.1","peptidyl-tRNA hydrolase ICT1, mitochondrial isoform 2 precursor","206",""
> "Q8BN58-1","NP_001334339.1","rho GTPase-activating protein 28 isoform 2","678",""
2785a2783
> "Q3UGR5-1","NP_001034290.1","haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform 1","259",""
2787d2784
< "Q8CIN6-1","NP_766022.1","CUGBP Elav-like family member 3 isoform 2","465",""
2792d2788
< "Q9CQV4-1","NP_083209.1","reticulophagy regulator 3 isoform 2","285",""
2794d2789
< "Q9D5K4-1","NP_083312.1","S100P-binding protein isoform 1","396",""
2799a2795
> "Q3V0J1-1","NP_001028621.1","transmembrane protein 237 isoform 1","413",""
2805d2800
< "Q6P8Y7-1","NP_079988.3","sorting nexin-31 isoform 1","438",""
2809a2805
> "Q0GGX2-1","NP_001092747.1","zinc finger protein 541 isoform 2","1363",""
2818a2815
> "Q9CZJ0-1","NP_001137155.1","metallophosphoesterase MPPED2 isoform a","294",""
2820d2816
< "Q3V0J1-1","NP_001032901.1","transmembrane protein 237 isoform 2","403",""
2822d2817
< "Q9D176-1","NP_082616.1","sushi domain-containing protein 3 isoform 2","257",""
2827a2823
> "Q9CQ80-1","NP_001271340.1","vacuolar protein-sorting-associated protein 25 isoform 1","184",""
2828a2825
> "Q8BUJ9-1","NP_001333965.1","low-density lipoprotein receptor-related protein 12 isoform 2 precursor","839",""
2830d2826
< "Q9CPV7-1","NP_080159.3","palmitoyltransferase ZDHHC6 isoform 1","413",""
2841a2838
> "Q9CPV7-1","NP_001028745.1","palmitoyltransferase ZDHHC6 isoform 1","413",""
2852d2848
< "Q9D131-1","NP_075972.2","UPF0686 protein C11orf1 homolog isoform 1","166",""
2854d2849
< "Q9CQ80-1","NP_081052.2","vacuolar protein-sorting-associated protein 25 isoform 2","176",""
2858a2854
> "Q9DAK8-1","NP_001156446.1","leucine-rich repeat-containing protein 51 isoform 2","146",""
2862d2857
< "Q8BHR8-1","NP_780332.1","UPF0705 protein C11orf49 homolog isoform 2","331",""
2873c2868
< "Q6PFX7-1","NP_780730.2","neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform 1","833",""
---
> "Q8CIN6-1","NP_001276542.1","CUGBP Elav-like family member 3 isoform 1","494",""
2875c2870
< "Q8BUL6-1","NP_598703.1","pleckstrin homology domain-containing family A member 1 isoform 1","356",""
---
> "Q7TSC3-1","NP_001334247.1","serine/threonine-protein kinase Nek5 isoform 2","627",""
2877,2878c2872
< "Q7TSC3-1","NP_808566.2","serine/threonine-protein kinase Nek5 isoform 1","614",""
< "P60954-1","NP_950189.2","nucleolar protein 4 isoform 2","483",""
---
> "Q6P8Y7-1","NP_001333951.1","sorting nexin-31 isoform 2","439",""
2887a2882
> "Q9D131-1","NP_001298002.1","UPF0686 protein C11orf1 homolog isoform 2","182",""
2889d2883
< "Q8R035-1","NP_081005.1","peptidyl-tRNA hydrolase ICT1, mitochondrial isoform 1","177",""
2896d2889
< "Q8BGF9-1","NP_001268724.1","solute carrier family 25 member 44 isoform b","314",""
2900a2894
> "Q9D176-1","NP_079767.2","sushi domain-containing protein 3 isoform 1","269",""
2905d2898
< "Q8R2Y8-1","NP_778169.1","peptidyl-tRNA hydrolase 2, mitochondrial isoform a","182",""
2913a2907
> "Q8R2Y8-1","NP_001092280.1","peptidyl-tRNA hydrolase 2, mitochondrial isoform b","181",""
2927c2921
< "Q8BGL3-1","NP_780459.1","sulfotransferase-like protein 1","282",""
---
> "Q8BGL3-1","NP_001186235.1","sulfotransferase-like protein 1","282",""
2929d2922
< "Q63ZW6-1","NP_031762.2","collagen alpha-5(IV) chain precursor","1691",""
2933c2926
< "Q7TNE6-1","NP_899245.1","double homeobox B-like 1","350",""
---
> "Q63ZW6-1","NP_001156627.1","collagen alpha-5(IV) chain precursor","1691",""
2935d2927
< "Q8C6G0-1","NP_919044.1","interferon, alpha-inducible protein 27 like 1 isoform 4","205",""
2936a2929
> "Q8C6G0-1","NP_919042.2","interferon, alpha-inducible protein 27 like 1 isoform 2","250",""
2939d2931
< "Q9JJG5-1","NP_067347.2","SERTA domain-containing protein 2 isoform 1","309",""
2943a2936
> "Q8VDU3-1","NP_001156355.1","apolipoprotein L 9a","310",""
2944a2938
> "D2J0Y4-1","NP_001074800.1","(E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 2","644",""
2947c2941
< "Q3UHC1-1","NP_001034175.1","rap guanine nucleotide exchange factor 1 isoform 2","1218",""
---
> "Q3UHC1-1","NP_001034176.1","rap guanine nucleotide exchange factor 1 isoform 1","1224",""
2957c2951
< "Q8VE28-1","NP_082462.3","protein naked cuticle homolog 2 isoform a","461",""
---
> "Q8VE28-1","NP_001334464.1","protein naked cuticle homolog 2 isoform b","449",""
2959a2954
> "Q8R1E9-1","NP_001093934.1","secretoglobin, family 2B, member 27 isoform 1 precursor","112",""
2965d2959
< "Q8R1E9-1","NP_001263404.1","secretoglobin, family 2B, member 27 isoform 2 precursor","82",""
2968c2962
< "E9Q732-1","NP_001156533.1","uncharacterized protein LOC71640","603",""
---
> "E9Q732-1","NP_001136415.1","uncharacterized protein LOC71640","603",""
2971d2964
< "Q6GQT0-1","NP_001167024.1","dual specificity protein phosphatase CDC14A isoform 2","554",""
2973,2974d2965
< "Q9DB40-1","NP_083891.1","mediator of RNA polymerase II transcription subunit 27 isoform b","208",""
< "Q5BL07-1","NP_082053.1","peroxisome biogenesis factor 1 isoform 2","1244",""
2976a2968
> "Q3V0L5-1","NP_001028633.1","leucine-rich repeat-containing protein 43 isoform 1","667",""
2978d2969
< "Q3UPY5-1","NP_722498.1","beta-galactosidase-1-like protein 2 isoform 1","652",""
2980a2972,2974
> "Q8VEL0-1","NP_001277443.1","motile sperm domain-containing protein 1 isoform 2","213",""
> "Q8C581-1","NP_001277426.1","transmembrane protein 91 isoform 2","141",""
> "Q8R0W1-1","NP_001276359.1","CLOCK-interacting pacemaker isoform a","411",""
2982,2983c2976,2982
< "Q8VEL0-1","NP_081685.1","motile sperm domain-containing protein 1 isoform 1","214",""
< "A2BFE8-1","NP_081598.1","transmembrane gamma-carboxyglutamic acid protein 1","218",""
---
> "Q3UV66-1","NP_001289488.1","schlafen 4","602","The protein encoded by this gene belongs to the Schlafen family. All members of this family contain a Schlafen box domain that lies near an AAA domain. This protein belongs to the group 2 subset of Schlafen proteins, which are defined by a molecular weight between 58 kDa and 68 kDa and by the presence of a SWADL domain that contains the sequence Ser-Trp-Ala-Asp-Leu. In malignant melanoma cells, gene expression is up-regulated in response to interferon alpha. In bone marrow-derived macrophages, expression of this gene is induced during activation by Toll-like receptor agonists and repressed during macrophage colony-stimulating factor-mediated differentiation. Myelopoiesis is disrupted by constitutive overexpression in myeloid-lineage cells. A pseudogene of this gene is found on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
> "Q9D410-1","NP_001136162.1","DMRT-like family C1c2 isoform 1","238",""
> "Q3UPY5-1","NP_001297697.1","beta-galactosidase-1-like protein 2 isoform 2 precursor","636",""
> "Q9D818-1","NP_001074554.1","suppressor APC domain-containing protein 2 isoform a","425",""
> "Q9DB40-1","NP_001277419.1","mediator of RNA polymerase II transcription subunit 27 isoform d","93",""
> "Q6TXD4-1","NP_001293017.1","dynamin-binding protein isoform 2","823","This gene encodes a member of the DBL family of guanine nucleotide exchange factors. The encoded protein has been proposed to regulate the actin cytoskeleton by specifically activating the Rho-family GTPase Cdc42. An interaction between the encoded protein and a Listeria protein has been shown to mediate Listeria infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
> "Q6DIA2-1","NP_001276416.1","exocyst complex component 3-like protein 4","721",""
2985,2991c2984,2985
< "Q8VHN8-1","NP_080115.1","tudor-interacting repair regulator protein isoform 1","211",""
< "Q3V0L5-1","NP_001276751.1","leucine-rich repeat-containing protein 43 isoform 3","657",""
< "Q8BQY8-1","NP_032342.1","checkpoint protein HUS1 isoform 1","281","This gene encodes a component of a cell cycle checkpoint complex that causes cell cycle arrest in response to bulky DNA lesions and DNA replication blockage. Together with the proteins Rad9 and Rad1, the encoded protein forms a heterotrimeric complex known as the 9-1-1 complex. Mice lacking the encoded protein develop spontaneous chromosomal abnormalities resulting in embryonic lethality. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]. "
< "Q9D289-1","NP_084333.1","trafficking protein particle complex subunit 6B isoform 1","158",""
< "Q6DIA2-1","NP_083083.3","exocyst complex component 3-like protein 4","721",""
< "Q3UV66-1","NP_035540.2","schlafen 4","602","The protein encoded by this gene belongs to the Schlafen family. All members of this family contain a Schlafen box domain that lies near an AAA domain. This protein belongs to the group 2 subset of Schlafen proteins, which are defined by a molecular weight between 58 kDa and 68 kDa and by the presence of a SWADL domain that contains the sequence Ser-Trp-Ala-Asp-Leu. In malignant melanoma cells, gene expression is up-regulated in response to interferon alpha. In bone marrow-derived macrophages, expression of this gene is induced during activation by Toll-like receptor agonists and repressed during macrophage colony-stimulating factor-mediated differentiation. Myelopoiesis is disrupted by constitutive overexpression in myeloid-lineage cells. A pseudogene of this gene is found on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
< "Q8C581-1","NP_796076.1","transmembrane protein 91 isoform 1","172",""
---
> "A2BFE8-1","NP_001157747.1","transmembrane gamma-carboxyglutamic acid protein 1","218",""
> "Q8BQY8-1","NP_001290461.1","checkpoint protein HUS1 isoform 2","280","This gene encodes a component of a cell cycle checkpoint complex that causes cell cycle arrest in response to bulky DNA lesions and DNA replication blockage. Together with the proteins Rad9 and Rad1, the encoded protein forms a heterotrimeric complex known as the 9-1-1 complex. Mice lacking the encoded protein develop spontaneous chromosomal abnormalities resulting in embryonic lethality. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]. "
2994d2987
< "Q8R0Z2-1","NP_666063.1","ecto-NOX disulfide-thiol exchanger 2 isoform a","598",""
2995a2989
> "Q8R0Z2-1","NP_001258376.1","ecto-NOX disulfide-thiol exchanger 2 isoform a","598",""
3004a2999
> "Q9D1F0-1","NP_001018073.1","retrotransposon Gag like 8B","113",""
3025d3019
< "Q75N62-1","NP_997651.1","GTPase IMAP family member 8 isoform 1","688","This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein is larger than the other gene family members and includes three AIG1 domains (corresponding to the AIG1 protein from Arabidopsis thaliana) whereas other family members have one AIG1 domain. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]. "
3026a3021
> "Q6GQW0-1","NP_001017525.1","ankyrin repeat and BTB/POZ domain-containing protein BTBD11 isoform 2","640",""
3035a3031
> "Q7TSD4-1","NP_001017407.1","protein TBATA isoform 5","197","This gene encodes a putative transcription factor that is highly expressed in thymic cortical stromal cells, and may be involved in T-cell development. Its expression is developmentally regulated in the testis, where it is restricted to the haploid round spermatids during spermatogenesis, and thus this gene may also have a role in the control of male germ cell development. Alternative splicing of this gene results in two sets of transcript variants: the variants containing 5 additional exons at the 3' end encode long isoforms that are highly expressed in the testis, while the variants lacking the 3' end exons encode short isoforms that are highly expressed in the thymus. Most of the transcripts encoding the short isoforms have been shown to initiate translation from non-AUG (CUG) start sites. [provided by RefSeq, Jul 2008]. "
3038a3035
> "Q8BH55-1","NP_001001297.1","threonine synthase-like 1 isoform b","226",""
3053,3054d3049
< "O55040-1","NP_034471.1","neuromedin-U receptor 1 isoform 2","405",""
< "Q3URJ8-1","NP_766575.2","sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 isoform 2 precursor","166",""
3067d3061
< "Q9D2W0-1","NP_387468.1","FXYD domain-containing ion transport regulator 4 precursor","88","This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. [provided by RefSeq, Jul 2008]. "
3079,3080d3072
< "Q9DAI4-1","NP_082223.2","zinc finger and BTB domain-containing protein 43 isoform a","504",""
< "Q8BH55-1","NP_808256.1","threonine synthase-like 1 isoform a","747",""
3096d3087
< "Q6PFX2-1","NP_796209.2","BEN domain-containing protein 6 isoform 1","281",""
3104d3094
< "Q7TSD4-1","NP_075551.3","protein TBATA isoform 3","231","This gene encodes a putative transcription factor that is highly expressed in thymic cortical stromal cells, and may be involved in T-cell development. Its expression is developmentally regulated in the testis, where it is restricted to the haploid round spermatids during spermatogenesis, and thus this gene may also have a role in the control of male germ cell development. Alternative splicing of this gene results in two sets of transcript variants: the variants containing 5 additional exons at the 3' end encode long isoforms that are highly expressed in the testis, while the variants lacking the 3' end exons encode short isoforms that are highly expressed in the thymus. Most of the transcripts encoding the short isoforms have been shown to initiate translation from non-AUG (CUG) start sites. [provided by RefSeq, Jul 2008]. "
3148a3139
> "Q8WUR0-1","NP_001078854.1","protein C19orf12 homolog","141",""
3157a3149,3150
> "C0LLJ0-1","NP_001013796.2","importin subunit alpha-8 isoform 2","499",""
> "Q9CXR4-1","NP_001034134.1","phosphatidylinositol N-acetylglucosaminyltransferase subunit C","297",""
3167a3161
> "Q5NCI0-1","NP_001071129.1","up-regulator of cell proliferation isoform 2","883",""
3175d3168
< "Q9CXR4-1","NP_080354.1","phosphatidylinositol N-acetylglucosaminyltransferase subunit C","297",""
3177a3171
> "Q9ET38-1","NP_001033679.1","claudin-19 isoform 1","224","This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. siRNA knockdown of this gene in mice develops the FHHNC (familial hypomagnesemia with hypercalciuria and nephrocalcinosis) symptoms of chronic renal wasting of magnesium and calcium together with defective renal salt handling. The protein encoded by this gene interacts with another family member, Claudin 16, and their interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium. This protein is a constituent of tight junctions in the Schwann cells of peripheral myelinated nerves and the gene deficiency affects the nerve conduction of peripheral myelinated fibers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]. "
3178a3173
> "Q75N62-1","NP_001070878.1","GTPase IMAP family member 8 isoform 1","688","This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein is larger than the other gene family members and includes three AIG1 domains (corresponding to the AIG1 protein from Arabidopsis thaliana) whereas other family members have one AIG1 domain. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]. "
3182d3176
< "A6H6A4-1","NP_080944.2","leucine-rich repeat and IQ domain-containing protein 4 isoform 1","596",""
3187d3180
< "A7TZF0-1","NP_808246.1","selection and upkeep of intraepithelial T-cells protein 3 isoform b precursor","386",""
3201a3195
> "Q8BSM7-1","NP_001077278.1","large neutral amino acids transporter small subunit 3 isoform 3","590",""
3203d3196
< "Q3ULW6-1","NP_083488.1","coiled-coil domain-containing protein 33 isoform 2","731",""
3208d3200
< "Q8K1L0-1","NP_766316.1","cyclic AMP-responsive element-binding protein 5 isoform 2","357",""
3213d3204
< "Q5SWZ9-1","NP_898962.2","mitochondrial cardiolipin hydrolase isoform b","147",""
3217,3218d3207
< "Q8CFI5-1","NP_758476.2","probable proline--tRNA ligase, mitochondrial isoform 1","475",""
< "Q5SS91-1","NP_808244.1","SUN domain-containing protein 3 isoform b","260",""
3234a3224
> "A2A7S8-1","NP_001028361.1","uncharacterized protein KIAA1522 isoform a","1070",""
3239d3228
< "Q9D3D0-1","NP_859423.2","alpha-tocopherol transfer protein-like isoform 1","343",""
3242d3230
< "Q5FWC3-1","NP_937867.2","membrane-spanning 4-domains subfamily A member 13 isoform 1","203",""
3243a3232
> "Q9QXC1-1","NP_001077373.1","fetuin-B isoform 2","308",""
3244a3234
> "P70225-1","NP_001092818.1","interleukin 11 receptor, alpha chain 2-like precursor","432",""
3255d3244
< "Q9D300-1","NP_083280.1","ras-GEF domain-containing family member 1C isoform 2","466",""
3259c3248,3249
< "A2APC3-1","NP_083340.2","probable tubulin polyglutamylase TTLL9 isoform 2","464",""
---
> "Q8BZW4-1","NP_075755.4","zinc finger protein 120 isoform 2 precursor","130",""
> "A0A0B4J1F4-1","NP_001036057.1","arrestin domain-containing protein 4 isoform 1","415",""
3274d3263
< "A0A0B4J1F4-1","NP_079825.2","arrestin domain-containing protein 4 isoform 2","296",""
3276a3266
> "Q921N7-1","NP_080668.1","transmembrane protein 70, mitochondrial isoform 2","254",""
3285a3276
> "A2AIW0-1","NP_001078876.1","endosome-associated-trafficking regulator 1 isoform 3","382",""
3289d3279
< "Q8WUR0-1","NP_082442.1","protein C19orf12 homolog","141",""
3295a3286
> "Q3TIR1-1","NP_001087228.1","trafficking protein particle complex subunit 13 isoform 2","417",""
3297,3298d3287
< "Q8CDD9-1","NP_082357.2","ligand-dependent nuclear receptor-interacting factor 1 isoform 2","237",""
< "Q3TIR1-1","NP_080155.3","trafficking protein particle complex subunit 13 isoform 1","418",""
3301d3289
< "Q99NF2-1","NP_064672.2","NMDA receptor synaptonuclear signaling and neuronal migration factor isoform C","509",""
3302a3291,3292
> "P14576-1","NP_001093579.1","signal recognition particle 54 kDa protein","504",""
> "A1Y9I9-1","NP_001075148.1","transmembrane O-methyltransferase homolog","258",""
3305d3294
< "Q8R0J4-1","NP_080165.1","transmembrane protein 134 isoform b","180",""
3313d3301
< "Q8BZW4-1","NP_851783.2","zinc finger protein 120 isoform 1 precursor","436",""
3327d3314
< "Q921N7-1","NP_081691.2","transmembrane protein 70, mitochondrial isoform 1","253",""
3328a3316
> "Q8BWR4-1","NP_001028463.1","ubiquitin carboxyl-terminal hydrolase 40 isoform 2","1146",""
3336d3323
< "Q505G8-1","NP_839998.2","zinc finger protein 827 isoform 1","1078",""
3337a3325
> "Q9JJG5-1","NP_001033714.1","SERTA domain-containing protein 2 isoform 1","309",""
3345d3332
< "Q8R070-1","NP_694702.1","glucose-6-phosphate exchanger SLC37A1","531",""
3350d3336
< "Q8R3I2-1","NP_080313.2","lysophospholipid acyltransferase 2 isoform a","519",""
3351a3338
> "Q3UZA1-1","NP_001033935.1","capZ-interacting protein isoform b","382",""
3354,3355d3340
< "Q8CFF0-1","NP_852067.1","protein mono-ADP-ribosyltransferase PARP11 isoform 1","331",""
< "Q8BFT6-1","NP_848774.1","2-oxoglutarate and iron-dependent oxygenase JMJD4 isoform 1","427",""
3356a3342,3343
> "Q8CFF0-1","NP_001333441.1","protein mono-ADP-ribosyltransferase PARP11 isoform 2","248",""
> "Q8BFT6-1","NP_001191997.1","2-oxoglutarate and iron-dependent oxygenase JMJD4 isoform 2","415",""
3358a3346
> "Q8R087-1","NP_001298066.1","beta-1,4-galactosyltransferase 7 isoform 2","292",""
3366d3353
< "Q8C7V8-1","NP_766016.2","coiled-coil domain-containing protein 134 isoform 1 precursor","229",""
3376d3362
< "Q91W53-1","NP_065610.2","golgin subfamily A member 7","137",""
3380a3367
> "Q9D4V3-1","NP_083532.1","coiled-coil domain-containing protein 83 isoform 2","305",""
3388d3374
< "Q99L20-1","NP_598755.1","glutathione S-transferase theta-3 isoform 1","241",""
3389a3376
> "Q91W53-1","NP_001035949.1","golgin subfamily A member 7","137",""
3408d3394
< "Q5PR68-1","NP_663721.2","centrosomal protein of 112 kDa isoform 3","173",""
3421a3408,3409
> "Q5K6N0-1","NP_001008973.2","transmembrane protein 232 isoform a","675",""
> "Q5M8Q2-1","NP_001104507.1","histone H2A-like 1","105",""
3423a3412,3413
> "Q8R3I2-1","NP_001076810.1","lysophospholipid acyltransferase 2 isoform b","487",""
> "Q5D525-1","NP_001041610.1","synaptonemal complex central element protein 1-like isoform 1","247",""
3430a3421
> "Q3TBN1-1","NP_001074863.1","transmembrane protein 248","314",""
3433d3423
< "Q9DCM7-1","NP_080771.3","nucleus accumbens-associated protein 2 isoform 1","586",""
3438c3428
< "Q3UGR5-1","NP_084102.1","haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform 1","259",""
---
> "A2AAX3-1","NP_001034148.1","kelch-like protein 15 isoform c","237",""
3444a3435
> "Q9D7G9-1","NP_001038948.1","MAPK-interacting and spindle-stabilizing protein","263",""
3449,3450d3439
< "Q5SPX1-1","NP_808284.2","coiled-coil domain-containing protein 157 isoform 2","616",""
< "A2AAX3-1","NP_694805.1","kelch-like protein 15 isoform c","237",""
3464d3452
< "Q8BKT8-1","NP_996987.1","HAUS augmin-like complex subunit 7 isoform 2","248",""
3472d3459
< "Q505H4-1","NP_796138.2","von Willebrand factor C domain-containing protein 2-like isoform 1 precursor","222",""
3495a3483
> "Q2MH31-1","NP_001041470.1","spermatid-specific manchette-related protein 1 isoform 1","260",""
3515d3502
< "Q921R8-1","NP_082144.2","solute carrier family 41 member 3 isoform 1","488",""
3516a3504
> "Q9DCM7-1","NP_001032175.1","nucleus accumbens-associated protein 2 isoform 2","586",""
3522d3509
< "Q4PJX1-1","NP_663486.2","protein odr-4 homolog isoform 1","447",""
3530a3518
> "C0HKC8-1","NP_001034978.1","sperm motility kinase 3B","504",""
3540d3527
< "Q8BIL2-1","NP_997160.1","myb/SANT-like DNA-binding domain-containing protein 1 isoform 1","278",""
3546a3534
> "A2APC3-1","NP_001077087.1","probable tubulin polyglutamylase TTLL9 isoform 1","461",""
3551d3538
< "Q9Z1L2-1","NP_067457.2","synaptogyrin-4 isoform 1","233",""
3553d3539
< "Q2MH31-1","NP_082900.1","spermatid-specific manchette-related protein 1 isoform 2","126",""
3559c3545
< "Q8BVN7-1","NP_780542.1","solute carrier family 25 member 41 isoform 1","312",""
---
> "Q80WJ1-1","NP_874353.2","gametogenetin isoform 1","709",""
3570d3555
< "Q9D7G9-1","NP_081391.1","MAPK-interacting and spindle-stabilizing protein","263",""
3572a3558
> "Q5PR68-1","NP_083862.1","centrosomal protein of 112 kDa isoform 1","102",""
3576d3561
< "Q5D525-1","NP_083415.1","synaptonemal complex central element protein 1-like isoform 2","242",""
3579,3580d3563
< "Q9Z223-2","NP_038854.2","molybdopterin synthase sulfur carrier subunit isoform Mocs2A","88","Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. Based on experiments with the human molybdopterin synthase ortholog, they are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008]. "
< "Q6TCG5-1","NP_940802.1","membrane progestin receptor delta isoform 1","343",""
3584d3566
< "Q6Q783-1","NP_666289.2","histone-lysine N-methyltransferase KMT5C","468",""
3586a3569
> "P11985-1","NP_001116839.1","t-complex-associated testis expressed 3-like isoform 1","191","This gene is one of three genes with a very high degree of similarity to each other within a 77 kb genomic span on Chromosome 17 A2. This gene lies between the other two gene copies. [provided by RefSeq, Jul 2008]. "
3590a3574
> "Q8BKT8-1","NP_082909.1","HAUS augmin-like complex subunit 7 isoform 1","364",""
3592d3575
< "Q9ET38-1","NP_694745.1","claudin-19 isoform 2","211","This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. siRNA knockdown of this gene in mice develops the FHHNC (familial hypomagnesemia with hypercalciuria and nephrocalcinosis) symptoms of chronic renal wasting of magnesium and calcium together with defective renal salt handling. The protein encoded by this gene interacts with another family member, Claudin 16, and their interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium. This protein is a constituent of tight junctions in the Schwann cells of peripheral myelinated nerves and the gene deficiency affects the nerve conduction of peripheral myelinated fibers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]. "
3595d3577
< "Q9Z1L3-1","NP_035745.3","death effector domain-containing protein","318",""
3597,3598d3578
< "Q8C4V1-1","NP_666273.1","rho GTPase-activating protein 24 isoform 2","654",""
< "Q3TTY0-1","NP_084348.1","phospholipase B1, membrane-associated isoform 2","834",""
3600d3579
< "Q3U213-1","NP_796285.2","protein SERAC1 isoform 2","624",""
3611d3589
< "Q8BGN2-1","NP_082943.2","UPF0462 protein C4orf33 homolog isoform a","192",""
3616a3595
> "Q5DTI6-1","NP_001116210.1","KAT8 regulatory NSL complex subunit 1-like protein isoform 1","956",""
3620a3600
> "Q3ULM6-1","NP_001013396.2","SUMO-specific isopeptidase USPL1 isoform C","517",""
3622d3601
< "Q3UJC8-1","NP_080403.4","uncharacterized protein C5orf34 homolog","639",""
3624a3604
> "Q6Q783-1","NP_001108490.1","histone-lysine N-methyltransferase KMT5C","468",""
3628c3608
< "Q62394-1","NP_033575.3","zinc finger protein 185 isoform a","486",""
---
> "Q6P1Z5-1","NP_001108013.1","PC-esterase domain-containing protein 1A","449",""
3632c3612,3613
< "Q5DTI6-1","NP_808313.3","KAT8 regulatory NSL complex subunit 1-like protein isoform 2","947",""
---
> "Q6PDG5-1","NP_001107568.1","SWI/SNF complex subunit SMARCC2 isoform 2","1130",""
> "O54972-1","NP_001103343.1","protein CBFA2T3 isoform 2","585",""
3642,3644c3623
< "Q6P1Z5-1","NP_848877.2","PC-esterase domain-containing protein 1A","449",""
< "Q8BXJ8-1","NP_848838.2","zinc finger protein 385B isoform 1","482",""
< "Q6P560-1","NP_001104546.1","zinc finger protein 182","627",""
---
> "Q9QVY8-1","NP_001096837.1","retinoic acid-induced protein 2","529",""
3655a3635
> "Q7TND5-1","NP_081608.1","ribosome production factor 1 isoform 1","212",""
3658c3638
< "Q8BVN3-1","NP_808534.1","cation channel sperm-associated protein 4 isoform 1","442",""
---
> "Q6PFY9-1","NP_001116461.1","dual specificity protein phosphatase CDC14B isoform 2","448",""
3660d3639
< "Q8BX07-1","NP_666124.1","carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 isoform b","119",""
3666,3667d3644
< "Q9D9T6-1","NP_082923.1","spermatogenesis-associated protein 3 isoform 3","192",""
< "Q6PFY9-1","NP_766175.3","dual specificity protein phosphatase CDC14B isoform 1","485",""
3672a3650
> "Q6P926-1","NP_082009.3","spermatogenesis-associated protein 24 isoform 1","185",""
3676a3655,3656
> "Q6P560-1","NP_001013405.2","zinc finger protein 182","627",""
> "Q9D9T6-1","NP_001116204.1","spermatogenesis-associated protein 3 isoform 3","192",""
3683d3662
< "Q9D9W1-1","NP_083880.2","protein pitchfork isoform b","207",""
3686a3666
> "Q66JV7-1","NP_001004155.2","uncharacterized protein C8orf58 homolog isoform 1","366",""
3720,3722d3699
< "A2ASZ8-1","NP_666230.2","calcium-binding mitochondrial carrier protein SCaMC-2 isoform 1","514",""
< "Q99ME6-1","NP_598451.1","protein ATP1B4 isoform 1","356",""
< "Q9R164-1","NP_064324.2","zinc finger protein 111 isoform 1","700",""
3724,3726c3701,3703
< "Q9QZR0-1","NP_067288.2","E3 ubiquitin-protein ligase RNF25 isoform 1","456",""
< "Q9CWV1-1","NP_079952.2","DNA helicase MCM8 isoform b","805",""
< "Q8VHM5-1","NP_083147.1","heterogeneous nuclear ribonucleoprotein R isoform a","632",""
---
> "Q9QZR0-1","NP_001292159.1","E3 ubiquitin-protein ligase RNF25 isoform 2","455",""
> "Q99ME6-1","NP_001277318.1","protein ATP1B4 isoform 2","352",""
> "Q8BRG8-1","NP_001298022.1","transmembrane protein 209 isoform 2","560",""
3728a3706,3707
> "Q8K1H1-1","NP_001277404.1","tudor domain-containing protein 7 isoform 1","1119",""
> "Q8BWB1-1","NP_001297361.1","synaptopodin 2-like protein isoform 3","749",""
3730a3710
> "Q9R164-1","NP_001297599.1","zinc finger protein 111 isoform 2","701",""
3731a3712,3713
> "Q8VHM5-1","NP_001264050.1","heterogeneous nuclear ribonucleoprotein R isoform a","632",""
> "A2ASZ8-1","NP_001157829.1","calcium-binding mitochondrial carrier protein SCaMC-2 isoform 2","502",""
3738,3739c3720
< "Q64329-1","NP_034781.2","killer cell lectin-like receptor subfamily A, member 9","266",""
< "Q3U108-1","NP_666108.2","AT-rich interactive domain-containing protein 5A isoform 3","532",""
---
> "Q2TJJ8-1","NP_034781.2","killer cell lectin-like receptor subfamily A, member 9","266",""
3753d3733
< "Q3ZN08-1","NP_598464.3","protein FAM220A","260",""
3755a3736
> "E9PWI7-1","NP_001157756.1","uncharacterized protein LOC381654","475",""
3756a3738
> "Q3ZN08-1","NP_080326.2","protein FAM220A","260",""
3779,3780c3761
< "Q8BLQ9-1","NP_848836.2","cell adhesion molecule 2 isoform 1 precursor","404",""
< "Q8BKE5-1","NP_001243074.1","DNA repair and recombination protein RAD54B isoform 2","98",""
---
> "Q8BLQ9-1","NP_001139449.1","cell adhesion molecule 2 isoform 2 precursor","395",""
3867d3847
< "P48301-1","NP_035695.1","transcriptional enhancer factor TEF-4 isoform a","445",""
3874a3855
> "P48301-1","NP_001272427.1","transcriptional enhancer factor TEF-4 isoform a","445",""
3880a3862
> "Q64GA5-1","NP_001004762.1","cytosolic phospholipase A2 gamma isoform 2","597",""
3882,3883d3863
< "Q64GA5-1","NP_001161976.1","cytosolic phospholipase A2 gamma isoform 1","607",""
< "Q99MQ4-1","NP_079987.2","asporin preproprotein","373","This gene encodes a member of the small leucine-rich proteoglycan family. The encoded protein is an extracellular matrix protein that modulates the transforming growth factor-beta signaling pathway, regulating cartilage matrix gene expression and cartilage formation. The protein plays a role in the pathology of osteoarthritis. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]. "
3886a3867
> "Q99MQ4-1","NP_001165952.1","asporin preproprotein","373","This gene encodes a member of the small leucine-rich proteoglycan family. The encoded protein is an extracellular matrix protein that modulates the transforming growth factor-beta signaling pathway, regulating cartilage matrix gene expression and cartilage formation. The protein plays a role in the pathology of osteoarthritis. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]. "
3927a3909
> "Q9D3H4-1","NP_001092816.1","Krtap2-4-like","131",""
3946d3927
< "Q5U4C1-1","NP_080357.4","G-protein coupled receptor-associated sorting protein 1","1347",""
4018d3998
< "Q6PAL8-1","NP_067469.1","DENN domain-containing protein 5A isoform 1","1287",""
4074d4053
< "Q6PKN7-1","NP_998894.1","protein INCA1 isoform 1","231",""
4075a4055
> "Q5U4C1-1","NP_001004359.1","G-protein coupled receptor-associated sorting protein 1","1347",""
4082d4061
< "Q8BK03-1","NP_780601.1","mitoguardin 2","593",""
4150d4128
< "Q6P3Z3-1","NP_080196.3","THAP domain-containing protein 4 isoform 1","569",""
4162d4139
< "Q8BIX3-1","NP_776111.1","ARL14 effector protein","276",""
4174a4152
> "Q99NF2-1","NP_001034475.1","NMDA receptor synaptonuclear signaling and neuronal migration factor isoform A","532",""
4195d4172
< "Q3UZA1-1","NP_848708.2","capZ-interacting protein isoform a","412",""
4199d4175
< "Q9ERL7-1","NP_071307.1","glia maturation factor gamma isoform a","142",""
4200a4177,4178
> "Q8QZY2-1","NP_001034675.1","glycerate kinase","523",""
> "Q9JKK7-1","NP_001033799.1","tropomodulin-2","351",""
4208a4187
> "Q9DAI4-1","NP_001020765.1","zinc finger and BTB domain-containing protein 43 isoform b","467",""
4215a4195
> "Q8R3I9-1","NP_001031817.1","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8","389",""
4217d4196
< "Q8R3I9-1","NP_666296.1","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8","389",""
4221d4199
< "Q8R361-1","NP_803417.3","rab11 family-interacting protein 5 isoform 2","645",""
4223c4201,4202
< "Q61114-1","NP_700467.2","BPI fold-containing family B member 1 isoform 2 precursor","474",""
---
> "Q8R2U0-1","NP_001034177.1","nucleoporin SEH1 isoform a","360",""
> "Q922T2-1","NP_663401.2","microfibril-associated glycoprotein 3 precursor","349",""
4244d4222
< "Q9JKK7-1","NP_057920.2","tropomodulin-2","351",""
4246a4225
> "Q3U381-1","NP_001035776.1","zinc finger protein 692","531",""
4253d4231
< "Q8QZY2-1","NP_777271.3","glycerate kinase","523",""
4259a4238
> "Q8R361-1","NP_001003955.1","rab11 family-interacting protein 5 isoform 1","1318",""
4265a4245
> "Q9ERL7-1","NP_001034281.1","glia maturation factor gamma isoform a","142",""
4278,4279d4257
< "Q8BPM6-1","NP_848895.2","protein RIC-3 isoform b precursor","228",""
< "Q3U381-1","NP_892041.2","zinc finger protein 692","531",""
4282a4261
> "Q8BPM6-1","NP_001033713.1","protein RIC-3 isoform a precursor","367",""
4286d4264
< "Q8BZJ7-1","NP_001036116.1","DCN1-like protein 2 isoform b","207",""
4293a4272
> "Q61114-1","NP_001012392.1","BPI fold-containing family B member 1 isoform 1 precursor","474",""
4302d4280
< "Q922T2-1","NP_850930.1","microfibril-associated glycoprotein 3 precursor","349",""
4311,4312d4288
< "Q8BYK4-1","NP_084293.1","retinol dehydrogenase 12 isoform 1 precursor","316","The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in the human gene are associated with Leber congenital amaurosis type 13, and Retinitis Pigmentosa 53. [provided by RefSeq, Sep 2015]. "
< "Q8BKW4-1","NP_084461.1","rRNA N6-adenosine-methyltransferase ZCCHC4 isoform 1","512",""
4315c4291,4292
< "Q5DTW7-1","NP_080330.1","retroelement silencing factor 1","1521",""
---
> "Q8BKW4-1","NP_001295073.1","rRNA N6-adenosine-methyltransferase ZCCHC4 isoform 2","489",""
> "Q5DTW7-1","NP_001276590.1","retroelement silencing factor 1","1521",""
4318a4296
> "Q8BYK4-1","NP_001300900.1","retinol dehydrogenase 12 isoform 2 precursor","304","The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in the human gene are associated with Leber congenital amaurosis type 13, and Retinitis Pigmentosa 53. [provided by RefSeq, Sep 2015]. "
4321d4298
< "A2ABV5-1","NP_036135.3","mediator of RNA polymerase II transcription subunit 14 isoform b","1437",""
4329d4305
< "Q7TQC5-1","NP_079821.3","aprataxin isoform a","342",""
4331d4306
< "Q9CQ60-1","NP_079672.1","6-phosphogluconolactonase isoform 1","257",""
4340a4316
> "Q3TTY0-1","NP_001074876.1","phospholipase B1, membrane-associated isoform 1 precursor","1478",""
4357,4358d4332
< "Q9D7S0-1","NP_081615.2","ly6/PLAUR domain-containing protein 8 preproprotein","255","This gene encodes a member of the Ly6/PLAUR family of cysteine-rich proteins that plays an important role in the protection of colonic epithelium from flagellated microbiota. The encoded protein undergoes proteolytic processing to generate a mature, glycosylphosphatidylinositol-anchored protein that is localized to the apical surface of the colonic epithelial cells. Mice lacking the encoded protein are sensitive to chemically induced intestinal inflammation. [provided by RefSeq, Aug 2016]. "
< "Q9DCS1-1","NP_079602.4","transmembrane protein 176A","244",""
4366d4339
< "Q4U4S6-1","NP_001077388.1","xin actin-binding repeat-containing protein 2 isoform 2","3283",""
4367a4341
> "Q9DAY5-1","NP_001077349.1","UPF0669 protein C6orf120 homolog precursor","185",""
4372a4347
> "Q8C398-1","NP_001071104.1","phosphatidylinositol-glycan biosynthesis class W protein","503",""
4374d4348
< "Q6NS82-1","NP_739561.2","reticulophagy regulator 2 isoform 1","541",""
4378d4351
< "Q924W5-1","NP_079971.2","structural maintenance of chromosomes protein 6 isoform 1","1097",""
4379a4353
> "Q80UX8-1","NP_001074588.1","protein ABHD13","337",""
4380a4355
> "Q8R4X3-1","NP_083673.3","RNA-binding protein 12","992","This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 2 H2. Two alternatively spliced transcript variants have been identified for this gene. Both variants encode the same protein. [provided by RefSeq, Jul 2008]. "
4386d4360
< "Q8BSM7-1","NP_078773.1","large neutral amino acids transporter small subunit 3 isoform 2","564",""
4389a4364
> "A2ABV5-1","NP_001041673.1","mediator of RNA polymerase II transcription subunit 14 isoform a","1459",""
4413a4389
> "Q9CRD4-1","NP_001041692.1","dysbindin domain-containing protein 2","158",""
4430a4407
> "Q8R0J4-1","NP_001072117.1","transmembrane protein 134 isoform a","195",""
4433,4435d4409
< "Q5NCI0-1","NP_848738.2","up-regulator of cell proliferation isoform 1","926",""
< "Q8C398-1","NP_081664.2","phosphatidylinositol-glycan biosynthesis class W protein","503",""
< "Q9ESG4-1","NP_065651.1","collectrin isoform 1 precursor","222",""
4437d4410
< "Q9D2L9-1","NP_080916.1","protein FAM111A isoform 1","613",""
4442d4414
< "A4QPC6-1","NP_787952.2","butyrophilin subfamily 2 member A2 isoform 1 precursor","514",""
4447d4418
< "Q3TEW6-1","NP_001077366.1","myelin protein zero-like protein 1 isoform a precursor","270",""
4455,4456c4426
< "A2A9F4-1","NP_598468.2","keratinocyte differentiation factor 1","397",""
< "Q8VCE9-1","NP_666142.1","pleckstrin homology domain-containing family H member 3 isoform 1 precursor","796",""
---
> "P97292-1","NP_001010973.1","histamine H2 receptor","397",""
4460d4429
< "Q8VEK6-1","NP_076115.3","inhibitor of growth protein 3 isoform 1","421",""
4462d4430
< "Q8VDM1-1","NP_659143.1","zinc finger CCCH-type with G patch domain-containing protein","511",""
4466a4435
> "Q9DCS1-1","NP_001091741.1","transmembrane protein 176A","244",""
4469d4437
< "Q9D638-1","NP_079996.2","keratin-associated protein 3-2","99",""
4477d4444
< "Q9CQ35-1","NP_080499.1","GLIPR1-like protein 2 isoform 1","332",""
4480d4446
< "A2AIW0-1","NP_080839.2","endosome-associated-trafficking regulator 1 isoform 1","432",""
4484d4449
< "Q9D8N6-1","NP_083653.1","protein lin-37 homolog isoform 1","246",""
4488d4452
< "Q8BUM9-1","NP_776115.2","ubiquitin carboxyl-terminal hydrolase 43 isoform 1","1132",""
4491d4454
< "Q5U4E2-1","NP_780308.2","replication initiator 1 isoform e","545",""
4498a4462
> "Q8VDM1-1","NP_001041613.1","zinc finger CCCH-type with G patch domain-containing protein","511",""
4504d4467
< "Q9CRD4-1","NP_081073.1","dysbindin domain-containing protein 2","158",""
4509c4472
< "Q9DAY5-1","NP_080727.2","UPF0669 protein C6orf120 homolog precursor","185",""
---
> "B2RRE7-1","NP_001074633.1","OTU domain-containing protein 4 isoform 2","1106",""
4511a4475
> "Q3UV70-1","NP_001028625.1","[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform c","538",""
4517d4480
< "Q8R4X3-1","NP_733486.2","RNA-binding protein 12","992","This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 2 H2. Two alternatively spliced transcript variants have been identified for this gene. Both variants encode the same protein. [provided by RefSeq, Jul 2008]. "
4519d4481
< "Q3UHE1-1","NP_001075110.1","membrane-associated phosphatidylinositol transfer protein 3 isoform 2","958",""
4522a4485
> "Q9D638-1","NP_079800.1","keratin-associated protein 3-3","99",""
4524a4488
> "Q3UHE1-1","NP_001020098.1","membrane-associated phosphatidylinositol transfer protein 3 isoform 1","974",""
4527d4490
< "Q9CRA9-1","NP_080494.1","FGFR1 oncogene partner 2 homolog isoform 1","253",""
4530a4494
> "Q3TEW6-1","NP_001001880.1","myelin protein zero-like protein 1 isoform b precursor","209",""
4532d4495
< "Q9DBU2-1","NP_083366.1","N-alpha-acetyltransferase 60 isoform 1","242",""
4550d4512
< "Q3UNN8-1","NP_795890.2","inactive phospholipase D5 isoform 1","536",""
4554d4515
< "Q8CCS2-1","NP_775622.1","transmembrane protein FAM155A isoform 1","467",""
4557a4519
> "Q9D7S0-1","NP_001077353.1","ly6/PLAUR domain-containing protein 8 preproprotein","255","This gene encodes a member of the Ly6/PLAUR family of cysteine-rich proteins that plays an important role in the protection of colonic epithelium from flagellated microbiota. The encoded protein undergoes proteolytic processing to generate a mature, glycosylphosphatidylinositol-anchored protein that is localized to the apical surface of the colonic epithelial cells. Mice lacking the encoded protein are sensitive to chemically induced intestinal inflammation. [provided by RefSeq, Aug 2016]. "
4559c4521
< "Q8BJI1-1","NP_758475.1","sodium-dependent neutral amino acid transporter SLC6A17 isoform2","724",""
---
> "A2A9F4-1","NP_001077385.1","keratinocyte differentiation factor 1","397",""
4561c4523,4525
< "Q69ZS8-1","NP_653114.3","kazrin isoform 1","779",""
---
> "Q8VHF2-1","NP_001107794.1","cadherin-related family member 5 isoform 1 precursor","831",""
> "Q6PDC8-1","NP_001108134.1","major facilitator superfamily domain-containing protein 4A isoform b","510",""
> "Q8BJ83-1","NP_081071.1","TM2 domain-containing protein 3 isoform 1","230",""
4564d4527
< "A7XV04-1","NP_808486.2","selection and upkeep of intraepithelial T-cells protein 7 isoform 2 precursor","252",""
4570c4533
< "Q6P926-1","NP_083761.1","spermatogenesis-associated protein 24 isoform 2","205",""
---
> "Q9Z1L3-1","NP_001122081.1","death effector domain-containing protein","318",""
4572a4536
> "P60060-1","NP_001103441.1","protein transport protein Sec61 subunit gamma isoform 2","68",""
4580d4543
< "A2AJL3-1","NP_083623.1","FGGY carbohydrate kinase domain-containing protein isoform b","387",""
4581a4545,4547
> "Q62394-1","NP_001102513.1","zinc finger protein 185 isoform b","485",""
> "Q8BX07-1","NP_001106941.1","carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 isoform a","270",""
> "Q8BGN2-1","NP_001093255.1","UPF0462 protein C4orf33 homolog isoform a","192",""
4589a4556
> "Q3TVI4-1","NP_001123987.1","protein HEXIM2","313",""
4591d4557
< "Q8VI33-1","NP_081415.1","transcription initiation factor TFIID subunit 9","264",""
4596c4562
< "Q7TND5-1","NP_081647.2","ribosome production factor 1 isoform 2","349",""
---
> "Q9Z223-2","NP_001106845.1","molybdopterin synthase sulfur carrier subunit isoform Mocs2B","189","Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. Based on experiments with the human molybdopterin synthase ortholog, they are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008]. "
4600,4601d4565
< "Q6PDG5-1","NP_937803.1","SWI/SNF complex subunit SMARCC2 isoform 3","1099",""
< "Q6PDC8-1","NP_766098.2","major facilitator superfamily domain-containing protein 4A isoform a","512",""
4604a4569
> "Q8BGR2-1","NP_001116240.1","volume-regulated anion channel subunit LRRC8D","859",""
4607d4571
< "O55142-1","NP_067313.2","60S ribosomal protein L35a","110",""
4610d4573
< "Q8K2V1-1","NP_666193.2","serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform a","951",""
4611a4575
> "Q9CR27-1","NP_001116432.1","WASH complex subunit 3 isoform 2","193",""
4614a4579
> "P39061-3","NP_001103461.1","collagen alpha-1(XVIII) chain isoform 1 precursor","1527",""
4617d4581
< "P60060-1","NP_035473.2","protein transport protein Sec61 subunit gamma isoform 1","100",""
4622d4585
< "Q9CWZ3-1","NP_080151.2","RNA-binding protein 8A isoform b","173",""
4627a4591
> "Q8K2V1-1","NP_001107603.1","serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform b","934",""
4642,4644c4606
< "Q9JL16-1","NP_065608.2","interferon-stimulated gene 20 kDa protein isoform b","181",""
< "Q9Z0E2-1","NP_034023.1","chordin isoform 1 precursor","948",""
< "Q3ULM0-1","NP_666290.2","coiled-coil domain-containing protein 106 isoform b","279",""
---
> "A2AJL3-1","NP_001106883.1","FGGY carbohydrate kinase domain-containing protein isoform a","552",""
4649d4610
< "Q8K2P6-1","NP_849247.3","Rieske domain-containing protein","157",""
4652d4612
< "Q8R2R9-1","NP_083781.2","AP-3 complex subunit mu-2","418",""
4653a4614
> "Q3TYX8-1","NP_001029232.2","RUN and FYVE domain-containing protein 4 isoform 2","479",""
4661d4621
< "Q6GQW0-1","NP_082985.2","ankyrin repeat and BTB/POZ domain-containing protein BTBD11 isoform 1","1109",""
4662a4623
> "Q8BVN3-1","NP_001123502.1","cation channel sperm-associated protein 4 isoform 2","369",""
4670c4631
< "Q5DU00-1","NP_808245.2","doublecortin domain-containing protein 2 isoform 1","475","This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Sep 2010]. "
---
> "Q571G4-1","NP_001108482.1","protein lin-54 homolog isoform 1","749",""
4672d4632
< "Q05A62-1","NP_083097.2","dynein light chain 1, axonemal isoform 1","190",""
4674d4633
< "Q3TVI4-1","NP_081934.1","protein HEXIM2","313",""
4690c4649
< "Q66JV7-1","NP_001106206.1","uncharacterized protein C8orf58 homolog isoform 2","365",""
---
> "B1AXP6-1","NP_001093145.1","mitochondrial import receptor subunit TOM5 homolog isoform 1","51",""
4692a4652
> "Q9DBY0-1","NP_001104294.1","forkhead box protein P4 isoform 1","685",""
4698d4657
< "Q715T0-1","NP_853622.2","thioredoxin domain-containing protein 3 isoform 1","586",""
4701d4659
< "Q810S1-1","NP_080055.2","calcium uniporter regulatory subunit MCUb, mitochondrial isoform1","345",""
4705a4664
> "Q8VI33-1","NP_001015889.1","transcription initiation factor TFIID subunit 9","264",""
4710d4668
< "Q9CYH2-1","NP_081740.2","peroxiredoxin-like 2A isoform c","218",""
4713c4671
< "Q4VA55-1","NP_780750.2","PWWP domain-containing DNA repair factor 3B","681",""
---
> "Q4VA55-1","NP_001158102.1","PWWP domain-containing DNA repair factor 3B","681",""
4719c4677,4678
< "Q8C779-1","NP_780535.1","RPA-related protein RADX isoform 1","850",""
---
> "Q8C779-1","NP_001333451.1","RPA-related protein RADX isoform 2","849",""
> "Q3UY90-1","NP_001186856.1","Golgi-associated kinase 1A isoform 2 precursor","527",""
4724d4682
< "Q3UY90-1","NP_808411.1","Golgi-associated kinase 1A isoform 1 precursor","546",""
4737d4694
< "Q9CZB6-1","NP_079702.3","mediator of RNA polymerase II transcription subunit 7","233",""
4741c4698,4699
< "Q91Z49-1","NP_081502.2","UAP56-interacting factor isoform 1","317",""
---
> "Q9CWZ3-1","NP_001095877.1","RNA-binding protein 8A isoform a","174",""
> "A2AVJ5-1","NP_001077279.1","proline-rich protein 5-like","370",""
4743c4701
< "Q3TDE8-1","NP_898963.2","zinc finger protein 691","283",""
---
> "P12400-1","NP_001139273.1","protein CTLA-2-beta isoform b","112",""
4744a4703
> "A2AWT3-1","NP_001092306.1","ataxin-7-like protein 3 isoform a","354",""
4748a4708
> "Q61211-1","NP_001129542.1","eukaryotic translation initiation factor 2D isoform 1","570",""
4751a4712
> "Q8BP99-1","NP_001013777.2","UPF0500 protein C1orf216 homolog","230",""
4752a4714
> "Q8VDB2-1","NP_001135829.1","dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform 1","486",""
4759d4720
< "Q80VP5-1","NP_082586.1","probable peptide chain release factor C12orf65 homolog, mitochondrial isoform b","128",""
4762d4722
< "Q3U4H6-1","NP_001139545.1","hexosaminidase D isoform 1","559",""
4766,4768c4726
< "Q9ERQ8-1","NP_444300.1","carbonic anhydrase 7 isoform a.","264",""
< "Q9Z2G9-1","NP_001139525.1","oxidoreductase HTATIP2 isoform b","242",""
< "Q499E0-1","NP_705767.3","BMP/retinoic acid-inducible neural-specific protein 3 isoform 1 precursor","766",""
---
> "Q91YK0-1","NP_001139518.1","leucine-rich repeat-containing protein 49 isoform 1","686",""
4771d4728
< "Q8BJ83-1","NP_835157.1","TM2 domain-containing protein 3 isoform 2 precursor","261",""
4774,4776c4731,4732
< "Q8BTC1-1","NP_001129041.1","uncharacterized protein C12orf73 homolog precursor","67",""
< "Q9D428-1","NP_081970.1","golgin subfamily A member 7B","167",""
< "A2AWT3-1","NP_001092307.1","ataxin-7-like protein 3 isoform b","347",""
---
> "Q8C5R2-1","NP_001153129.1","proline and serine-rich protein 2","471",""
> "Q69ZS8-1","NP_001103154.1","kazrin isoform 2","425",""
4778,4782c4734,4736
< "Q9JJN6-1","NP_075954.1","beta-catenin-interacting protein 1","81",""
< "Q8VCT3-1","NP_663392.2","aminopeptidase B isoform 1","650",""
< "B1AXP6-1","NP_001128118.1","mitochondrial import receptor subunit TOM5 homolog isoform 2","61",""
< "Q91X58-1","NP_081122.2","AN1-type zinc finger protein 2B","257",""
< "P39061-3","NP_034059.2","collagen alpha-1(XVIII) chain isoform 2 precursor","1315",""
---
> "Q08ED0-1","NP_001136431.1","bcl-2-like protein 15 isoform 1","167",""
> "Q9CXP9-1","NP_001153515.1","exonuclease V","373",""
> "Q8C6K9-1","NP_001096077.1","collagen alpha-6(VI) chain isoform 1 precursor","2265",""
4784c4738,4739
< "Q61211-1","NP_034839.2","eukaryotic translation initiation factor 2D isoform 2","552",""
---
> "Q9DAE8-1","NP_001153831.1","UPF0739 protein C1orf74 homolog","263",""
> "Q3TBD2-1","NP_001136173.1","rho GTPase-activating protein 45 isoform 1","1116",""
4787d4741
< "Q8BJ64-1","NP_780552.1","choline dehydrogenase, mitochondrial","596",""
4800d4753
< "Q9JK30-1","NP_056639.3","origin recognition complex subunit 3 isoform 1","715",""
4803a4757
> "Q8CCF0-1","NP_001153186.1","U4/U6 small nuclear ribonucleoprotein Prp31 isoform 2","493",""
4805d4758
< "Q8BQN5-1","NP_780670.2","protein FAM78B","261",""
4809c4762
< "Q8BN58-1","NP_766552.3","rho GTPase-activating protein 28 isoform 1","729",""
---
> "Q99KC8-1","NP_001139429.1","von Willebrand factor A domain-containing protein 5A","793",""
4813d4765
< "Q24JP3-1","NP_958753.2","protein FAM178B isoform C","379",""
4816,4819d4767
< "Q6AXF6-1","NP_932151.2","SID1 transmembrane family member 1 isoform 2 precursor","827",""
< "Q497K7-1","NP_084380.1","transmembrane protein 247 isoform 1","211",""
< "Q6SKR2-1","NP_080642.1","methyltransferase N6AMT1 isoform 1","214",""
< "Q8C729-1","NP_766101.3","protein FAM126B isoform b","530",""
4825a4774
> "O88834-1","NP_001152995.1","SH2 domain-containing adapter protein D isoform 1","344",""
4827d4775
< "Q9DAE8-1","NP_851391.1","UPF0739 protein C1orf74 homolog","263",""
4830a4779
> "Q8CDN9-1","NP_001136200.1","leucine-rich repeat-containing protein 9 isoform 1","1456",""
4833d4781
< "Q9CWU9-1","NP_082610.1","nucleoporin Nup37","326",""
4836c4784,4786
< "Q8BGY6-1","NP_473393.2","lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase","376",""
---
> "Q8K2J9-1","NP_001139372.1","BTB/POZ domain-containing protein 6 isoform 2","488",""
> "Q8K2P6-1","NP_001124540.1","Rieske domain-containing protein","157",""
> "Q9D9K8-1","NP_001140173.1","IQ domain-containing protein F1 isoform 2","147",""
4845c4795
< "Q91YK0-1","NP_663591.3","leucine-rich repeat-containing protein 49 isoform 2","752",""
---
> "Q3UJC8-1","NP_001107022.1","uncharacterized protein C5orf34 homolog","639",""
4847d4796
< "Q3UQI9-1","NP_808551.2","probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform 2","600",""
4849d4797
< "Q8C6K9-1","NP_766515.2","collagen alpha-6(VI) chain isoform 2 precursor","1182",""
4851c4799,4800
< "Q8BLY1-1","NP_071711.2","SPARC-related modular calcium-binding protein 1 isoform 2 precursor","452",""
---
> "Q3TDE8-1","NP_001139407.1","zinc finger protein 691","283",""
> "Q3UQI9-1","NP_001136253.1","probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform 1","744",""
4853a4803
> "Q8BLY1-1","NP_001139689.1","SPARC-related modular calcium-binding protein 1 isoform 1 precursor","463",""
4854a4805
> "P58058-1","NP_001153109.1","NAD kinase isoform 1","439",""
4858d4808
< "Q99LI5-1","NP_808311.1","zinc finger protein 281","893",""
4860d4809
< "Q8VE95-1","NP_789798.2","UPF0598 protein C8orf82 homolog isoform 2","77",""
4862a4812
> "Q99LI5-1","NP_001153723.1","zinc finger protein 281","893",""
4864c4814,4815
< "Q8R3C1-1","NP_666282.3","uncharacterized protein C2orf42 homolog isoform 1","574",""
---
> "Q8R1U2-1","NP_001153621.1","cell growth regulator with EF hand domain protein 1 isoform 2 precursor","280",""
> "Q4PNJ2-1","NP_001013429.2","sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 long isoform","208",""
4866d4816
< "Q9CQ07-1","NP_080529.1","leucine-rich repeat-containing protein 18 isoform 1","262",""
4867a4818
> "Q91W67-1","NP_001116345.1","ubiquitin-like protein 7","380",""
4881d4831
< "Q99KC8-1","NP_766355.3","von Willebrand factor A domain-containing protein 5A","793",""
4884d4833
< "O54803-1","NP_035158.2","P2X purinoceptor 6 isoform 1","389",""
4890a4840,4841
> "Q8BTC1-1","NP_001129039.1","uncharacterized protein C12orf73 homolog precursor","67",""
> "Q80ZU4-1","NP_001012685.2","small integral membrane protein 19 isoform 1","112",""
4891a4843
> "Q8VCT3-1","NP_001153096.1","aminopeptidase B isoform 2","611",""
4892a4845
> "Q9CQ07-1","NP_001139493.1","leucine-rich repeat-containing protein 18 isoform 2","255",""
4895c4848,4849
< "Q9D856-1","NP_082368.1","zinc transporter ZIP5 precursor","535",""
---
> "Q9D428-1","NP_001135455.1","golgin subfamily A member 7B","167",""
> "Q5FW56-1","NP_001137143.1","transmembrane protein 255B isoform 1","328",""
4898a4853
> "Q8BP47-1","NP_001136422.1","asparagine--tRNA ligase, cytoplasmic isoform 1","559",""
4902c4857
< "Q8BG47-1","NP_848894.1","E3 ubiquitin-protein ligase RNF152","203",""
---
> "Q9D856-1","NP_001129709.1","zinc transporter ZIP5 precursor","535",""
4904c4859
< "Q9DBY0-1","NP_083043.2","forkhead box protein P4 isoform 3","672",""
---
> "Q9CZB6-1","NP_001098000.1","mediator of RNA polymerase II transcription subunit 7","233",""
4909d4863
< "Q921U8-1","NP_038898.2","smoothelin isoform b","921",""
4913a4868
> "Q8VE95-1","NP_663447.1","UPF0598 protein C8orf82 homolog isoform 1","218",""
4915d4869
< "Q8BJ42-1","NP_766498.2","disks large-associated protein 2 isoform 1","1059",""
4918c4872
< "Q8VDB2-1","NP_663452.1","dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform 2","385",""
---
> "Q9D0I6-1","NP_001153108.1","WD repeat, SAM and U-box domain-containing protein 1 isoform 2","423",""
4926a4881
> "Q8BJ42-1","NP_001139437.1","disks large-associated protein 2 isoform 2","1060",""
4930c4885
< "Q8R218-1","NP_808555.1","modulator of macroautophagy TMEM150B isoform 2","123",""
---
> "Q9JL16-1","NP_001106999.1","interferon-stimulated gene 20 kDa protein isoform b","181",""
4934a4890
> "Q499E0-1","NP_001139279.1","BMP/retinoic acid-inducible neural-specific protein 3 isoform 1 precursor","766",""
4938,4940d4893
< "Q8R1U2-1","NP_081046.1","cell growth regulator with EF hand domain protein 1 isoform 1","325",""
< "Q3UMM4-1","NP_919428.1","cyclin-dependent kinase 10 isoform 1","360","The protein encoded by this gene belongs to the CDK (cyclin-dependent kinase) subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. The human ortholog has been shown to play a role in cellular proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 1. [provided by RefSeq, Jan 2010]. "
< "Q571G4-1","NP_766302.2","protein lin-54 homolog isoform 1","749",""
4948a4902
> "Q8BJ64-1","NP_001129712.1","choline dehydrogenase, mitochondrial","596",""
4949a4904
> "Q9CQ56-1","NP_001139252.1","vesicle transport protein USE1 isoform 3","284",""
4952c4907
< "Q8CCF0-1","NP_081604.3","U4/U6 small nuclear ribonucleoprotein Prp31 isoform 1","499",""
---
> "Q8R2R9-1","NP_001116292.1","AP-3 complex subunit mu-2","418",""
4956c4911
< "Q9CR27-1","NP_081763.1","WASH complex subunit 3 isoform 3","179",""
---
> "Q3V3Z3-1","NP_001028640.2","adhesion G-protein coupled receptor G5 isoform 2 precursor","523",""
4963d4917
< "Q5FW56-1","NP_001137144.1","transmembrane protein 255B isoform 2","307",""
4966a4921
> "Q8CIB6-1","NP_001135443.1","transmembrane protein 230","120",""
4969,4970d4923
< "Q8VHF2-1","NP_082345.1","cadherin-related family member 5 isoform 2 precursor","669",""
< "Q9CQA9-1","NP_079912.1","cancer-related nucleoside-triphosphatase homolog isoform 1","190",""
4971a4925,4926
> "Q62293-1","NP_001138636.1","T-cell-specific guanine nucleotide triphosphate-binding protein 2","415",""
> "Q9CY28-1","NP_001152801.1","GTP-binding protein 8 isoform 2","218",""
4973d4927
< "Q8BP99-1","NP_001139422.1","UPF0500 protein C1orf216 homolog","230",""
4978,4979d4931
< "Q8K2J9-1","NP_964008.2","BTB/POZ domain-containing protein 6 isoform 1","539",""
< "Q91VA3-1","NP_570960.2","calpain-8 isoform 1","703",""
4981d4932
< "Q8BWY2-1","NP_780735.2","C-type lectin domain family 1 member A isoform 1","269",""
4983c4934
< "Q8BGR2-1","NP_848816.3","volume-regulated anion channel subunit LRRC8D","859",""
---
> "Q14BP6-1","NP_001138907.1","leucine-rich repeat-containing protein 74B isoform 2","359",""
4984a4936
> "O55142-1","NP_001123956.1","60S ribosomal protein L35a","110",""
4987d4938
< "Q08ED0-1","NP_001136432.1","bcl-2-like protein 15 isoform 2","165",""
4990d4940
< "Q8BUE7-1","NP_666183.2","mucin-20 isoform b precursor","656",""
4992,4995d4941
< "Q80ZU4-1","NP_001139589.1","small integral membrane protein 19 isoform 2","107",""
< "A2AVJ5-1","NP_780390.3","proline-rich protein 5-like","370",""
< "Q9D9K8-1","NP_083119.1","IQ domain-containing protein F1 isoform 1","182",""
< "Q8CDN9-1","NP_084346.2","leucine-rich repeat-containing protein 9 isoform 2","1155",""
4997a4944
> "Q80VQ1-1","NP_001139520.1","leucine-rich repeat-containing protein 1 isoform 1","524",""
5001c4948
< "Q8CIB6-1","NP_081754.2","transmembrane protein 230","120",""
---
> "Q8R218-1","NP_001136264.1","modulator of macroautophagy TMEM150B isoform 1","238",""
5004d4950
< "Q9CY28-1","NP_079608.1","GTP-binding protein 8 isoform 1","285",""
5007,5008d4952
< "Q80VQ1-1","NP_766116.3","leucine-rich repeat-containing protein 1 isoform 2","479",""
< "Q8VD62-2","NP_598910.2","UPF0696 protein C11orf68 homolog isoform a","298",""
5013d4956
< "Q91W67-1","NP_081362.2","ubiquitin-like protein 7","380",""
5014a4958
> "Q5XJY6-1","NP_001139553.1","Fanconi anemia group B protein homolog isoform 1","853",""
5016d4959
< "Q14BP6-1","NP_083329.2","leucine-rich repeat-containing protein 74B isoform 1","391",""
5020d4962
< "Q8VHQ3-1","NP_694729.1","protein phosphatase 1 regulatory inhibitor subunit 16B","568",""
5024,5025d4965
< "O54972-1","NP_796263.1","protein CBFA2T3 isoform 3","559",""
< "Q3V3Z3-1","NP_001139444.1","adhesion G-protein coupled receptor G5 isoform 1 precursor","524",""
5027d4966
< "Q9Z0Y1-1","NP_058586.3","dynactin subunit 3 isoform A","186",""
5035c4974,4975
< "Q3TBD2-1","NP_081797.1","rho GTPase-activating protein 45 isoform 2","1000",""
---
> "Q3U213-1","NP_001104487.1","protein SERAC1 isoform 3","654",""
> "Q66JT5-1","NP_001004361.2","tubulin polyglutamylase complex subunit 2 isoform a","296",""
5038d4977
< "Q91WU4-1","NP_084133.1","transmembrane and coiled-coil domain-containing protein 4","631",""
5041a4981
> "Q921U8-1","NP_001152756.1","smoothelin isoform b","921",""
5045a4986
> "A7XV04-1","NP_001136247.1","selection and upkeep of intraepithelial T-cells protein 7 isoform 1 precursor","395",""
5054a4996,4997
> "Q9D061-1","NP_001139253.1","acyl-CoA-binding domain-containing protein 6 isoform 2","139",""
> "Q9WUP7-1","NP_001153338.1","ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2","328",""
5056d4998
< "Q3UPC7-1","NP_001139148.1","uncharacterized protein KIAA0825 homolog isoform 1","1272",""
5062a5005
> "Q8BUE7-1","NP_001139346.1","mucin-20 isoform a precursor","688",""
5070a5014
> "Q6AXF6-1","NP_001152891.1","SID1 transmembrane family member 1 isoform 1 precursor","832",""
5077a5022,5023
> "Q8BGY6-1","NP_001152879.1","lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase","376",""
> "Q9Z2G9-1","NP_001139521.1","oxidoreductase HTATIP2 isoform b","242",""
5080a5027
> "Q9CWU9-1","NP_081467.2","nucleoporin Nup37","326",""
5082a5030
> "Q9JK30-1","NP_001153035.1","origin recognition complex subunit 3 isoform 2","714",""
5088a5037
> "Q8BQN5-1","NP_001153733.1","protein FAM78B","261",""
5091d5039
< "Q9D061-1","NP_082526.2","acyl-CoA-binding domain-containing protein 6 isoform 1","282",""
5096d5043
< "Q9D0I6-1","NP_082394.1","WD repeat, SAM and U-box domain-containing protein 1 isoform 1","474",""
5098,5099d5044
< "Q8C5R2-1","NP_659132.2","proline and serine-rich protein 2","471",""
< "Q7M6U3-1","NP_113563.2","inactive serine/threonine-protein kinase TEX14 isoform b","1450",""
5100a5046
> "Q9Z0Y1-1","NP_001153037.1","dynactin subunit 3 isoform B","159",""
5102a5049
> "Q8CI96-1","NP_084455.2","CAP-Gly domain-containing linker protein 4 isoform 1","704",""
5108d5054
< "Q9CQ56-1","NP_080193.1","vesicle transport protein USE1 isoform 1","270",""
5112c5058
< "Q8VEA6-1","NP_598470.3","chordin-like protein 2 isoform 2 precursor","426",""
---
> "Q9JJN6-1","NP_001135402.1","beta-catenin-interacting protein 1","81",""
5120c5066,5068
< "Q9CXP9-1","NP_082733.1","exonuclease V","373",""
---
> "A4Q9E5-1","NP_001136204.1","tubulin monoglycylase TTLL3 isoform 2","287",""
> "Q8BG47-1","NP_001153840.1","E3 ubiquitin-protein ligase RNF152","203",""
> "Q8VHQ3-1","NP_001153134.1","protein phosphatase 1 regulatory inhibitor subunit 16B","568",""
5122d5069
< "Q66JT5-1","NP_001136170.1","tubulin polyglutamylase complex subunit 2 isoform c","241",""
5124c5071
< "P12400-1","NP_031823.1","protein CTLA-2-beta isoform a","113",""
---
> "O54803-1","NP_001153033.1","P2X purinoceptor 6 isoform 2","362",""
5128c5075,5076
< "Q9CZJ0-1","NP_084113.1","metallophosphoesterase MPPED2 isoform a","294",""
---
> "Q8K2Q2-1","NP_080895.2","glutathione S-transferase omega-2","248",""
> "Q91X58-1","NP_001153377.1","AN1-type zinc finger protein 2B","257",""
5132a5081
> "Q6SKR2-1","NP_001152803.1","methyltransferase N6AMT1 isoform 2","138",""
5145a5095
> "Q91Z49-1","NP_001152821.1","UAP56-interacting factor isoform 2","283",""
5147c5097
< "Q9WUP7-1","NP_062508.2","ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 1","329",""
---
> "Q3UMM4-1","NP_919426.2","cyclin-dependent kinase 10 isoform 2","289","The protein encoded by this gene belongs to the CDK (cyclin-dependent kinase) subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. The human ortholog has been shown to play a role in cellular proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 1. [provided by RefSeq, Jan 2010]. "
5149a5100
> "Q91VA3-1","NP_001139278.1","calpain-8 isoform 2","381",""
5153a5105
> "Q9CQX0-1","NP_001171312.1","ubiquitin thioesterase OTUB2 isoform 1","323",""
5155d5106
< "Q9CQ20-1","NP_080800.1","mid1-interacting protein 1","182",""
5157,5158d5107
< "Q8CIG0-1","NP_083799.2","DEP domain-containing protein 1A isoform 2","804",""
< "Q14DQ1-1","NP_780482.1","protein FAM219B isoform 2","128",""
5165d5113
< "Q3TYU2-1","NP_783581.2","probable cation-transporting ATPase 13A5 isoform 1","1216",""
5171a5120
> "Q715T0-1","NP_001161381.1","thioredoxin domain-containing protein 3 isoform 2","470",""
5175a5125
> "Q99LJ7-1","NP_001164165.1","RCC1 and BTB domain-containing protein 2","551",""
5176a5127
> "Q9D9R7-1","NP_001033705.2","doublesex- and mab-3-related transcription factor C1 isoform c","182",""
5177a5129
> "Q8VDI1-1","NP_083771.1","epithelial-stromal interaction protein 1 isoform a","314",""
5181c5133,5134
< "Q80W69-1","NP_082785.1","uncharacterized protein C12orf71 homolog isoform 1","301",""
---
> "Q9CWD3-1","NP_001156397.1","nucleoside diphosphate-linked moiety X motif 17 isoform 2","313",""
> "Q8BSV3-1","NP_001177329.1","BEN domain-containing protein 7 isoform 2","433",""
5183a5137
> "Q8C790-1","NP_001165687.1","protein FAM221A isoform 2","258",""
5197a5152
> "Q9QZN4-1","NP_001157176.1","F-box only protein 6","295",""
5199a5155
> "Q99KN1-1","NP_001155957.1","arrestin domain-containing protein 1 isoform a","434",""
5202a5159
> "Q99N64-1","NP_001161809.1","germ cell-less protein-like 2","498",""
5204c5161
< "Q3UUV5-1","NP_001171370.1","src kinase-associated phosphoprotein 1 isoform 3","339",""
---
> "Q9DB94-1","NP_001172091.1","WD repeat-containing protein 53","358",""
5206,5210d5162
< "Q3URE9-1","NP_780725.2","leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor","606",""
< "Q6IQX7-1","NP_001001566.1","chondroitin sulfate synthase 2 isoform a","774",""
< "Q8BTE5-1","NP_001170874.1","protein CEBPZOS","80",""
< "Q9CPZ3-1","NP_080567.1","uncharacterized protein C1orf185 homolog isoform 1","230",""
< "Q9CXX9-1","NP_077154.2","CUE domain-containing protein 2 isoform a","284",""
5213,5217c5165,5167
< "Q6PD29-1","NP_780520.3","zinc finger protein 513 isoform 1","541",""
< "Q8BHD4-1","NP_766457.1","FERM domain-containing protein 3 isoform 1","595",""
< "Q8BYN5-1","NP_795940.1","FSD1-like protein isoform 2","131",""
< "B7ZNG4-1","NP_084435.1","tastin","668",""
< "Q8K375-1","NP_722472.1","leucine-rich repeat-containing protein 56 isoform a","552",""
---
> "Q8K0V2-1","NP_001157175.1","DCN1-like protein 3","304",""
> "Q8BW88-1","NP_001157735.1","pleckstrin homology domain-containing family S member 1 isoform 2","474",""
> "Q6PGN3-1","NP_001182425.1","serine/threonine-protein kinase DCLK2 isoform 1","771","This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. This gene and the DCX gene, another family member, share function in the establishment of hippocampal organization and their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]. "
5218a5169,5171
> "P86793-1","NP_001180595.1","predicted gene 13304 precursor","133",""
> "Q9CPX9-1","NP_001033319.1","anaphase-promoting complex subunit 11","84",""
> "Q80ST9-1","NP_081724.1","lebercilin isoform b","704",""
5219a5173
> "Q9DAS9-1","NP_001171027.1","guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12","72",""
5221c5175,5177
< "Q8BYK5-1","NP_083082.1","phosphatase and actin regulator 3 isoform 1","558",""
---
> "Q811B5-1","NP_001159364.1","proline-rich protein 3 isoform b","88",""
> "Q8BWU8-1","NP_001157059.1","ethanolamine-phosphate phospho-lyase","499",""
> "Q6DIA7-1","NP_001157224.1","uncharacterized protein C19orf57 homolog isoform 2","565",""
5223d5178
< "Q9DCQ7-1","NP_080963.2","alpha-1-antitrypsin 1-6 isoform 1 precursor","411",""
5225c5180,5181
< "Q3TC33-1","NP_077163.1","coiled-coil domain-containing protein 127 isoform 1","260",""
---
> "Q8BGX3-1","NP_001165678.1","leucine-rich repeat and transmembrane domain-containing protein 2 precursor","370",""
> "Q8K2D6-1","NP_001154987.1","deoxycytidylate deaminase","184",""
5226a5183
> "Q2KHK6-1","NP_001161746.1","gasdermin-C2","480",""
5228c5185
< "Q8BUE4-1","NP_835159.1","apoptosis-inducing factor 2 isoform 2","373",""
---
> "Q3KNM2-1","NP_001157808.1","E3 ubiquitin-protein ligase MARCH5 isoform 2","244",""
5232c5189,5190
< "Q921Z5-1","NP_598892.2","tumor necrosis factor alpha-induced protein 8 isoform 1","212",""
---
> "Q3URE9-1","NP_001159471.1","leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor","606",""
> "Q3UTY6-1","NP_001035516.2","thrombospondin type-1 domain-containing protein 4 isoform a precursor","1018",""
5238,5239d5195
< "Q8BYZ1-1","NP_079935.1","ABI gene family member 3 isoform 1","367",""
< "Q9D306-1","NP_080519.2","alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C","478",""
5241,5243d5196
< "Q9D5Q8-1","NP_081888.1","uncharacterized protein C1orf141 homolog isoform 1","446",""
< "Q8BGX3-1","NP_766080.1","leucine-rich repeat and transmembrane domain-containing protein 2 precursor","370",""
< "Q6P5D3-1","NP_945180.2","putative ATP-dependent RNA helicase DHX57 isoform 2","1335",""
5245,5247c5198
< "Q6NXY1-1","NP_001161151.1","TBC1 domain family member 31 isoform 2","845",""
< "Q49B93-1","NP_001171095.1","sodium-coupled monocarboxylate transporter 2 isoform 2","619",""
< "Q5I012-1","NP_077211.4","putative sodium-coupled neutral amino acid transporter 10 isoform 1","1090",""
---
> "Q3TNH5-1","NP_001156892.1","cotranscriptional regulator FAM172A isoform 3","307",""
5249d5199
< "G3XA57-1","NP_001157839.1","rab11 family-interacting protein 2 isoform 2","370",""
5251d5200
< "Q6PG16-1","NP_941054.2","Holliday junction recognition protein","667",""
5253,5254d5201
< "Q9D820-1","NP_080741.1","prolyl-tRNA synthetase associated domain-containing protein 1 isoform 2","169",""
< "Q9ET43-1","NP_075028.1","claudin-12","244","This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene, along with several other family members, is expressed in the inner ear. The protein encoded by this gene and another family member, claudin 2, are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found. [provided by RefSeq, Oct 2011]. "
5258d5204
< "Q6PGN3-1","NP_081815.3","serine/threonine-protein kinase DCLK2 isoform 2","756","This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. This gene and the DCX gene, another family member, share function in the establishment of hippocampal organization and their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]. "
5260d5205
< "P0DN90-1","NP_080955.1","transmembrane protein 254 isoform 1","123",""
5264d5208
< "Q810A5-1","NP_083164.1","uncharacterized protein KIAA0895-like","467",""
5266,5267c5210,5211
< "Q8BGT8-1","NP_848736.2","phytanoyl-CoA hydroxylase-interacting protein-like isoform 1","375",""
< "Q8BW88-1","NP_766229.2","pleckstrin homology domain-containing family S member 1 isoform 1","474",""
---
> "Q9CRW3-1","NP_001165545.1","UPF0538 protein C2orf76 homolog isoform 2","121",""
> "Q8BYZ1-1","NP_001156936.1","ABI gene family member 3 isoform 2","314",""
5268a5213
> "Q99KZ6-1","NP_001155290.1","zinc finger protein 639","485",""
5271a5217
> "Q8BZM1-1","NP_001155210.1","glomulin isoform a","596",""
5274,5275c5220
< "P0C8K7-1","NP_001157194.1","small integral membrane protein 1","78",""
< "Q9QZ09-1","NP_038657.2","putative homeodomain transcription factor 1 isoform a","761",""
---
> "Q99JS0-1","NP_001161970.1","noncompact myelin-associated protein isoform 1","100",""
5280d5224
< "Q9D541-1","NP_083337.1","coiled-coil domain-containing protein 7 isoform 1","371",""
5283c5227
< "A7XUY5-1","NP_001161350.1","selection and upkeep of intraepithelial T-cells protein 5 isoform 2 precursor","1440",""
---
> "Q91WJ7-1","NP_001158038.1","SPATS2-like protein isoform 2","557",""
5284a5229
> "Q6IQX7-1","NP_001001565.1","chondroitin sulfate synthase 2 isoform b","612",""
5285a5231
> "Q9D3X9-1","NP_001171352.1","microfibrillar-associated protein 3-like isoform a precursor","409",""
5290a5237
> "Q9D5Q8-1","NP_001156966.1","uncharacterized protein C1orf141 homolog isoform 2","345",""
5293c5240
< "Q91WL6-1","NP_083241.1","sorting nexin-11","271",""
---
> "Q99K28-1","NP_001159496.1","ADP-ribosylation factor GTPase-activating protein 2 isoform 1","534","This gene encodes a zinc-finger-containing GTPase-activating protein for ADP ribosylation factor 1 (ARF1), a small GTPase that plays a role in coatomer-mediated vesicular trafficking. This gene product stimulates the hydrolysis of ARF1-bound GTP, which may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. It may regulate the retrograde transport from the Golgi complex to the endoplasmic reticulum. Expression of this gene has been shown to be controlled by inhibitor of DNA binding 1 (Id1). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 6. [provided by RefSeq, Oct 2009]. "
5296a5244,5246
> "Q9D478-1","NP_001156010.1","protein BCAP isoform 1","642",""
> "Q3UQ84-1","NP_001157089.1","threonine--tRNA ligase, mitochondrial isoform 2","697",""
> "Q8VHL0-1","NP_001164481.1","urea transporter 1 isoform a","440",""
5303,5304d5252
< "Q9DCG9-1","NP_080582.3","multifunctional methyltransferase subunit TRM112-like protein","125",""
< "Q9CXT7-1","NP_082703.1","transmembrane protein 192 isoform 1","266",""
5307a5256,5258
> "Q9D6X5-1","NP_001158291.1","solute carrier family 52, riboflavin transporter, member 3 isoform 1 precursor","460",""
> "Q80W69-1","NP_001157708.1","uncharacterized protein C12orf71 homolog isoform 2","300",""
> "Q9JJA4-1","NP_001185989.1","ribosome biogenesis protein WDR12","423",""
5309a5261
> "B2B9E1-1","NP_001165272.1","triple QxxK/R motif-containing protein","86",""
5316d5267
< "Q3UQ84-1","NP_082207.2","threonine--tRNA ligase, mitochondrial isoform 1","723",""
5321d5271
< "Q3TBN1-1","NP_082130.1","transmembrane protein 248","314",""
5329,5330c5279,5281
< "Q5M6W3-1","NP_082780.1","clathrin heavy chain linker domain-containing protein 1 isoform 1","596",""
< "Q7TPB0-1","NP_859009.2","phospholipid phosphatase-related protein type 3 isoform 1","716",""
---
> "Q8BXT9-1","NP_001158034.1","vesicle-trafficking protein SEC22c","303",""
> "Q3U1T9-1","NP_001159973.1","DENN domain-containing protein 1B isoform 1","766",""
> "Q9CPV1-1","NP_001157827.1","spindle and kinetochore-associated protein 1","254",""
5332c5283
< "Q5FW57-1","NP_001161379.1","glycine N-acyltransferase-like protein","296",""
---
> "B7ZNG4-1","NP_001155978.1","tastin","668",""
5335,5336d5285
< "Q6P1E8-1","NP_084222.4","EF-hand calcium-binding domain-containing protein 6 isoform 1","1516",""
< "Q9CZY2-1","NP_079979.2","transcription elongation factor A protein-like 8","117",""
5338,5341c5287
< "Q9QZ15-1","NP_036129.1","C-type lectin domain family 4 member A isoform b","238",""
< "Q9DAS9-1","NP_079554.1","guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12","72",""
< "Q6NZE7-1","NP_084443.1","protein FAM122B isoform 2","256",""
< "Q68FL6-1","NP_001165053.1","methionine--tRNA ligase, cytoplasmic isoform 1","910","The encoded protein belongs to the class I family of tRNA synthetases, a class of enzymes that charge tRNAs with their cognate amino acids. The related human gene product is essential for the translation initiation of mRNAs. This gene has an overlapping 3' UTR tail-to-tail arrangement with an adjacent gene on the opposite strand that encodes an inhibitor of the CCAAT/enhancer-binding protein's DNA binding activity. This arrangement, conserved in human and mouse, may be involved in mRNA stability and possible functional and regulatory interaction of these adjacent overlapping genes. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]. "
---
> "Q9QZ09-1","NP_001156939.1","putative homeodomain transcription factor 1 isoform a","761",""
5343d5288
< "Q5RJI5-1","NP_001162044.1","serine/threonine-protein kinase BRSK1 isoform 2","343",""
5344a5290
> "Q3U1D0-1","NP_001177930.1","protein Lines homolog 1 isoform 2","759",""
5346a5293
> "Q9DCQ7-1","NP_001158214.1","alpha-1-antitrypsin 1-6 isoform 2 precursor","356",""
5348d5294
< "Q9D823-1","NP_080345.1","60S ribosomal protein L37","97",""
5351,5353c5297
< "Q8BW41-1","NP_705768.4","protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 precursor","580",""
< "Q3UBZ5-1","NP_081438.4","MIF4G domain-containing protein isoform 1","222",""
< "P59055-1","NP_848749.2","cysteine/serine-rich nuclear protein 3 isoform a","597",""
---
> "Q8K1C0-1","NP_001185949.1","protein angel homolog 2 isoform 2","522",""
5356d5299
< "Q91X77-1","NP_598905.2","cytochrome P450 2C50 isoform 1 precursor","490",""
5358d5300
< "Q8JZV4-1","NP_705814.1","RNA-binding protein 41 isoform 2","413",""
5361d5302
< "Q6ZWU9-1","NP_081291.1","40S ribosomal protein S27","84",""
5364d5304
< "Q8BQJ6-1","NP_766128.2","tRNA (uracil(54)-C(5))-methyltransferase homolog isoform a","493",""
5365a5306
> "P84444-1","NP_001180596.1","predicted gene 1987 precursor","133",""
5367c5308
< "Q80ST9-1","NP_083710.2","lebercilin isoform a","419",""
---
> "Q5M6W3-1","NP_001156993.1","clathrin heavy chain linker domain-containing protein 1 isoform 2","585",""
5370a5312,5313
> "Q3U1V8-1","NP_001167578.1","mitogen-activated protein kinase kinase kinase 9 isoform 1","1077",""
> "A7DTG3-1","NP_001171265.1","SERTA domain-containing protein 4","377",""
5372,5373d5314
< "Q99JS0-1","NP_851390.1","noncompact myelin-associated protein isoform 1","100",""
< "Q8BLD6-1","NP_084174.2","ankyrin repeat domain-containing protein 55 isoform 1","626",""
5378,5380c5319
< "Q99KX1-1","NP_663360.1","myeloid leukemia factor 2","247",""
< "Q9ES64-1","NP_710143.2","harmonin isoform b3","910",""
< "Q8BSV3-1","NP_848778.1","BEN domain-containing protein 7 isoform 1","434",""
---
> "G3XA57-1","NP_001028344.2","rab11 family-interacting protein 2 isoform 1","529",""
5382d5320
< "Q8R574-1","NP_659055.1","phosphoribosyl pyrophosphate synthase-associated protein 2 isoform a","369",""
5384a5323
> "Q8R3A2-1","NP_001158097.1","cysteine-rich DPF motif domain-containing protein 1","119",""
5385a5325
> "Q8BWL5-1","NP_001165592.1","RNA-binding motif, single-stranded-interacting protein 3 isoform 4","463",""
5388c5328
< "Q8BMZ5-1","NP_077130.1","tRNA-splicing endonuclease subunit Sen34 isoform a","316",""
---
> "Q6P5D3-1","NP_001157231.1","putative ATP-dependent RNA helicase DHX57 isoform 1","1388",""
5390,5391d5329
< "Q8VHL0-1","NP_082398.1","urea transporter 1 isoform b","384",""
< "Q9DB94-1","NP_081174.1","WD repeat-containing protein 53","358",""
5393d5330
< "Q80UX8-1","NP_081144.1","protein ABHD13","337",""
5396d5332
< "Q9D1H0-1","NP_598669.1","RBPJ-interacting and tubulin-associated protein 1","253",""
5400d5335
< "Q91WD1-1","NP_080221.3","DNA-directed RNA polymerase III subunit RPC4","398",""
5412a5348,5351
> "Q5SPX1-1","NP_001158092.1","coiled-coil domain-containing protein 157 isoform 1","718",""
> "Q8BYK5-1","NP_001007155.1","phosphatase and actin regulator 3 isoform 2","518",""
> "Q8R0P4-1","NP_001171416.1","mth938 domain-containing protein isoform 1","150",""
> "Q9D920-1","NP_001163950.1","BLOC-1-related complex subunit 5 isoform 1","196",""
5414c5353,5354
< "Q99KZ6-1","NP_653102.1","zinc finger protein 639","485",""
---
> "Q8BHD4-1","NP_001157204.1","FERM domain-containing protein 3 isoform 2","554",""
> "Q9D9N8-1","NP_001156899.1","protease-associated domain-containing protein 1 isoform b precursor","188",""
5419d5358
< "Q8K0V2-1","NP_775584.1","DCN1-like protein 3","304",""
5420a5360
> "Q8BL65-1","NP_001171168.1","actin-binding LIM protein 2 isoform 2","617",""
5421a5362
> "Q6PGG6-1","NP_001162071.1","guanine nucleotide-binding protein-like 3-like protein","577",""
5423a5365
> "Q6NSU3-1","NP_001159402.1","glycosyltransferase 8 domain-containing protein 1","371","This gene encodes a member of the glycosyltransferase family. The encoded protein is a type II transmembrane protein containing a glycosyltransferase 8 domain in the lumenal (C-terminal) portion. The specific function of this protein has not been determined. Two alternatively spliced variants encoding the same isoform have been described. [provided by RefSeq, Sep 2009]. "
5425,5427c5367
< "Q9D3W1-1","NP_082006.1","radial spoke head 14 homolog isoform 2","373",""
< "Q9CPV1-1","NP_079857.3","spindle and kinetochore-associated protein 1","254",""
< "P58404-1","NP_598550.2","striatin-4 isoform 1","760",""
---
> "Q8CGA3-1","NP_001186212.1","large neutral amino acids transporter small subunit 4","568",""
5429c5369
< "Q3U1T9-1","NP_851992.1","DENN domain-containing protein 1B isoform 2","691",""
---
> "Q80WR5-1","NP_001156491.1","UPF0688 protein C1orf174 homolog isoform 2","192",""
5438a5379
> "Q8BTV2-1","NP_001157744.1","cleavage and polyadenylation specificity factor subunit 7 isoform 2","462",""
5443d5383
< "Q7TQG0-1","NP_775575.2","zinc finger and BTB domain-containing protein 5","670",""
5447,5448c5387
< "Q3TYX8-1","NP_001164112.1","RUN and FYVE domain-containing protein 4 isoform 1","563",""
< "Q8BMD5-1","NP_082262.1","cytidine and dCMP deaminase domain-containing protein 1 isoform 2","523",""
---
> "Q8BKD6-1","NP_001164114.1","E3 ubiquitin-protein ligase RNF144B","301",""
5450,5451d5388
< "Q9DBX3-1","NP_082166.3","sushi domain-containing protein 2 isoform 1 precursor","820",""
< "Q9CQX0-1","NP_080856.1","ubiquitin thioesterase OTUB2 isoform 2","234",""
5456d5392
< "Q99LI2-1","NP_663518.1","chloride channel CLIC-like protein 1 isoform 2 precursor","539",""
5460d5395
< "Q80Y50-1","NP_835217.1","calmodulin-binding transcription activator 2 isoform 1","1208",""
5462,5463c5397,5398
< "Q3KNM2-1","NP_081590.3","E3 ubiquitin-protein ligase MARCH5 isoform 1","278",""
< "Q3UW55-1","NP_001171319.1","WAP four-disulfide core domain protein 6A isoform 1 precursor","146",""
---
> "Q8CHP6-1","NP_001159426.1","polyhomeotic-like protein 3 isoform 1","993",""
> "Q6PD29-1","NP_001171372.1","zinc finger protein 513 isoform 2","539",""
5467d5401
< "Q8C963-1","NP_080253.2","coiled-coil domain-containing protein 159 isoform 2","403",""
5469a5404
> "Q3TC33-1","NP_001162129.1","coiled-coil domain-containing protein 127 isoform 2","163",""
5471d5405
< "Q8BX46-1","NP_766034.2","SKI family transcriptional corepressor 1 isoform 1","964",""
5475a5410
> "Q9CXY1-1","NP_001157004.1","endosomal/lysosomal potassium channel TMEM175 isoform 1","499",""
5476a5412
> "Q80WG7-1","NP_001164326.1","E3 ubiquitin-protein ligase Trim36 isoform 2","717",""
5478d5413
< "P61922-1","NP_766549.2","4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor","500","The encoded gene product is responsible for catabolism of gamma-aminobutyric acid (GABA), a mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. Deficiency of this encoded protein includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]. "
5481,5483d5415
< "Q8QZZ7-1","NP_789812.1","EKC/KEOPS complex subunit Tprkb isoform a","175",""
< "Q9JJA4-1","NP_067287.1","ribosome biogenesis protein WDR12","423",""
< "Q505B8-1","NP_082230.2","synaptonemal complex central element protein 2 isoform 2","171",""
5484a5417
> "Q8C0M0-1","NP_001164213.1","GATOR complex protein WDR59 isoform 3","974",""
5491a5425
> "Q3UFJ6-1","NP_001155020.1","transmembrane protein 184A isoform 1","449",""
5494,5495c5428,5432
< "Q8C0M0-1","NP_795897.2","GATOR complex protein WDR59 isoform 2","991",""
< "Q922G2-1","NP_663528.1","protein FAM76A isoform A","307",""
---
> "Q5FW57-1","NP_001013784.2","glycine N-acyltransferase-like protein","296",""
> "Q8JZV4-1","NP_001165618.1","RNA-binding protein 41 isoform 1","425",""
> "Q8BH61-1","NP_001159863.1","coagulation factor XIII A chain precursor","732","This gene encodes subunit A of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway. The encoded protein associates with subunit B to form a heterotetrameric proenzyme that undergoes thrombin-mediated proteolysis to generate active factor XIIIa. The transglutaminase activity of factor XIIIa is required for the calcium-dependent crosslinking of fibrin, leading to the formation of a clot. Mice lacking the encoded protein display impaired reproduction and reduced survival due to bleeding episodes, hematothorax, hematoperitoneum and subcutaneous hemorrhage. Additionally, mice lacking the encoded protein exhibit impaired wound healing and inadequate healing of myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. "
> "P70303-1","NP_001162040.1","CTP synthase 2 isoform a","586",""
> "Q14DQ1-1","NP_001159836.1","protein FAM219B isoform 1","197",""
5498c5435,5436
< "Q9DCT6-1","NP_665701.1","chromatin complexes subunit BAP18 isoform 2","171",""
---
> "Q49B93-1","NP_001003915.1","sodium-coupled monocarboxylate transporter 2 isoform 1","623",""
> "Q9CXP4-1","NP_001158099.1","rho GTPase-activating protein 8","425",""
5501,5505c5439
< "Q9D2Q8-1","NP_079669.2","protein S100-A14 isoform a","104",""
< "Q6NSU3-1","NP_083902.2","glycosyltransferase 8 domain-containing protein 1","371","This gene encodes a member of the glycosyltransferase family. The encoded protein is a type II transmembrane protein containing a glycosyltransferase 8 domain in the lumenal (C-terminal) portion. The specific function of this protein has not been determined. Two alternatively spliced variants encoding the same isoform have been described. [provided by RefSeq, Sep 2009]. "
< "Q3V1L4-1","NP_084086.3","cytosolic purine 5'-nucleotidase isoform 3","560",""
< "Q6GU68-1","NP_036173.1","immunoglobulin superfamily containing leucine-rich repeat protein precursor","428",""
< "Q8BMD7-1","NP_083689.2","MORC family CW-type zinc finger protein 4 isoform B","883",""
---
> "Q8K441-1","NP_001160028.1","ATP-binding cassette sub-family A member 6 isoform 2","388",""
5512a5447,5448
> "Q810I0-1","NP_001186606.1","vacuolar protein sorting-associated protein 37D isoform 1","261",""
> "Q91WL6-1","NP_001156861.1","sorting nexin-11","271",""
5521d5456
< "Q5HZI2-1","NP_941016.2","C2 calcium-dependent domain-containing protein 4C","419",""
5524d5458
< "Q99LJ7-1","NP_598844.3","RCC1 and BTB domain-containing protein 2","551",""
5525a5460
> "Q8C3X2-1","NP_001156390.1","coiled-coil domain-containing protein 90B, mitochondrial isoform 2","222",""
5526a5462
> "A7XUY5-1","NP_001161348.1","selection and upkeep of intraepithelial T-cells protein 5 isoform 1 precursor","1461",""
5527a5464,5466
> "P59999-1","NP_001163956.1","actin-related protein 2/3 complex subunit 4 isoform 2","91",""
> "Q9ET43-1","NP_001180588.1","claudin-12","244","This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene, along with several other family members, is expressed in the inner ear. The protein encoded by this gene and another family member, claudin 2, are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found. [provided by RefSeq, Oct 2011]. "
> "Q3UW55-1","NP_001028412.1","WAP four-disulfide core domain protein 6A isoform 2 precursor","136",""
5529d5467
< "Q8C790-1","NP_766315.1","protein FAM221A isoform 1","301",""
5531d5468
< "Q8K441-1","NP_671751.2","ATP-binding cassette sub-family A member 6 isoform 1","1624",""
5533a5471
> "Q921Z5-1","NP_001171231.1","tumor necrosis factor alpha-induced protein 8 isoform 3","136",""
5534a5473
> "Q7M6U3-1","NP_001186222.1","inactive serine/threonine-protein kinase TEX14 isoform a","1462",""
5538c5477
< "Q5HZH2-1","NP_080952.2","ribosome biogenesis protein TSR3 homolog isoform 1","323",""
---
> "Q5RJI5-1","NP_001003920.2","serine/threonine-protein kinase BRSK1 isoform 1","778",""
5540,5541d5478
< "G3X9G7-1","NP_766351.3","zinc finger protein 809 isoform 1","402",""
< "Q9R0Q4-1","NP_062742.4","mortality factor 4-like protein 2","288",""
5543,5544d5479
< "Q9D478-1","NP_079990.2","protein BCAP isoform 2","589",""
< "Q8CHP6-1","NP_700470.2","polyhomeotic-like protein 3 isoform 2","981",""
5547c5482
< "Q6X786-1","NP_081337.2","zona pellucida-binding protein 2 isoform 1 precursor","326",""
---
> "Q9D820-1","NP_001156926.1","prolyl-tRNA synthetase associated domain-containing protein 1 isoform 1","62",""
5548a5484
> "Q8R574-1","NP_001157714.1","phosphoribosyl pyrophosphate synthase-associated protein 2 isoform a","369",""
5550c5486
< "Q6DIA7-1","NP_083321.2","uncharacterized protein C19orf57 homolog isoform 1","600",""
---
> "P60670-1","NP_001181952.1","nuclear protein localization protein 4 homolog isoform A","608",""
5551a5488
> "Q91V76-1","NP_001186413.1","ester hydrolase C11orf54 homolog isoform 1","315",""
5552a5490
> "Q9CPZ3-1","NP_001186019.1","uncharacterized protein C1orf185 homolog isoform 2","226",""
5555d5492
< "Q8BH61-1","NP_083060.2","coagulation factor XIII A chain precursor","732","This gene encodes subunit A of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway. The encoded protein associates with subunit B to form a heterotetrameric proenzyme that undergoes thrombin-mediated proteolysis to generate active factor XIIIa. The transglutaminase activity of factor XIIIa is required for the calcium-dependent crosslinking of fibrin, leading to the formation of a clot. Mice lacking the encoded protein display impaired reproduction and reduced survival due to bleeding episodes, hematothorax, hematoperitoneum and subcutaneous hemorrhage. Additionally, mice lacking the encoded protein exhibit impaired wound healing and inadequate healing of myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. "
5557a5495
> "Q7TQG0-1","NP_001156755.1","zinc finger and BTB domain-containing protein 5","670",""
5562d5499
< "Q9D920-1","NP_080647.2","BLOC-1-related complex subunit 5 isoform 2","195",""
5564a5502,5503
> "Q505B8-1","NP_001161716.1","synaptonemal complex central element protein 2 isoform 3","88",""
> "Q3TNA1-1","NP_001028381.1","xylulose kinase isoform 1","551",""
5566d5504
< "Q9D9N8-1","NP_082781.1","protease-associated domain-containing protein 1 isoform a precursor","132",""
5567a5506
> "Q8K375-1","NP_001165535.1","leucine-rich repeat-containing protein 56 isoform a","552",""
5570c5509
< "Q9QZN4-1","NP_056612.1","F-box only protein 6","295",""
---
> "Q8C0P5-1","NP_001158276.1","coronin-2A isoform 2","524",""
5572d5510
< "Q9D9R7-1","NP_083654.1","doublesex- and mab-3-related transcription factor C1 isoform b","156",""
5573a5512
> "Q3UUV5-1","NP_001028358.1","src kinase-associated phosphoprotein 1 isoform 1","355",""
5578d5516
< "Q8CBW4-1","NP_848854.3","DDB1- and CUL4-associated factor 12-like protein 1","501",""
5581,5582c5519,5520
< "Q9D5I4-1","NP_080376.1","tctex1 domain-containing protein 1 isoform 1","173",""
< "Q3UFJ6-1","NP_659163.3","transmembrane protein 184A isoform 2","425",""
---
> "Q91X77-1","NP_001161347.1","cytochrome P450 2C50 isoform 2 precursor","431",""
> "Q6PFY8-1","NP_001159424.1","tripartite motif-containing protein 45 isoform b","580",""
5586c5524,5525
< "Q9CXY1-1","NP_082499.3","endosomal/lysosomal potassium channel TMEM175 isoform 1","499",""
---
> "Q6ZWU9-1","NP_001177187.1","ribosomal protein S27-like","84",""
> "O09046-1","NP_001164495.1","L-amino-acid oxidase precursor","638","This locus represents naturally-occurring readthrough transcription between Nup62 (nucleoporin 62) and Il4i1 (interleukin 4 induced 1). It encodes a protein sharing similarity with the protein encoded by Il4i1, but with a longer and distinct N-terminus. [provided by RefSeq, Aug 2015]. "
5593,5594c5532,5533
< "Q6PGG6-1","NP_932778.1","guanine nucleotide-binding protein-like 3-like protein","577",""
< "A0A0R4J1Z0-1","NP_001166059.1","MAS-related GPR, member A2A","331",""
---
> "Q91WW4-1","NP_001166059.1","MAS-related GPR, member A2A","331",""
> "P61922-1","NP_001164449.1","4-aminobutyrate aminotransferase, mitochondrial isoform 2 precursor","444","The encoded gene product is responsible for catabolism of gamma-aminobutyric acid (GABA), a mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. Deficiency of this encoded protein includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]. "
5599,5600c5538
< "Q811B5-1","NP_663462.2","proline-rich protein 3 isoform a","190",""
< "Q3UTY6-1","NP_766032.1","thrombospondin type-1 domain-containing protein 4 isoform b precursor","658",""
---
> "Q8C963-1","NP_001158086.1","coiled-coil domain-containing protein 159 isoform 1","411",""
5601a5540
> "Q68FL6-1","NP_001003913.1","methionine--tRNA ligase, cytoplasmic isoform 2","902","The encoded protein belongs to the class I family of tRNA synthetases, a class of enzymes that charge tRNAs with their cognate amino acids. The related human gene product is essential for the translation initiation of mRNAs. This gene has an overlapping 3' UTR tail-to-tail arrangement with an adjacent gene on the opposite strand that encodes an inhibitor of the CCAAT/enhancer-binding protein's DNA binding activity. This arrangement, conserved in human and mouse, may be involved in mRNA stability and possible functional and regulatory interaction of these adjacent overlapping genes. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]. "
5606d5544
< "Q9D4G9-1","NP_083180.3","recQ-mediated genome instability protein 1","616",""
5608a5547
> "P62313-1","NP_001177933.1","U6 snRNA-associated Sm-like protein LSm6","80",""
5613d5551
< "Q8K1C0-1","NP_067396.3","protein angel homolog 2 isoform 1","544",""
5621d5558
< "Q8JZM6-1","NP_666088.1","TRAF-interacting protein with FHA domain-containing protein B","147",""
5622a5560
> "P58404-1","NP_001034967.1","striatin-4 isoform 2","753",""
5625,5627c5563,5564
< "Q99N08-1","NP_082871.2","membrane-spanning 4-domains subfamily A member 6C isoform 1","217",""
< "Q8CGM1-1","NP_775094.2","adhesion G protein-coupled receptor B2 isoform 1 precursor","1549",""
< "Q8BWU8-1","NP_082183.2","ethanolamine-phosphate phospho-lyase","499",""
---
> "Q9DCG9-1","NP_001159842.1","multifunctional methyltransferase subunit TRM112-like protein","125",""
> "Q3UNN8-1","NP_001182745.1","inactive phospholipase D5 isoform 2 precursor","474",""
5632a5570
> "Q922G2-1","NP_001157264.1","protein FAM76A isoform B","278",""
5634c5572,5573
< "A7DTG3-1","NP_937890.2","SERTA domain-containing protein 4","377",""
---
> "C0HK80-1","NP_083817.1","adipocyte-related X-chromosome expressed sequence 1","180",""
> "Q8QZZ7-1","NP_001163959.1","EKC/KEOPS complex subunit Tprkb isoform a","175",""
5637c5576
< "Q3U0L2-1","NP_081772.1","ankyrin repeat domain-containing protein 33B isoform 2","477",""
---
> "Q91VC9-1","NP_001186051.1","growth hormone-inducible transmembrane protein","346",""
5645a5585
> "Q9D2W0-1","NP_001166843.1","FXYD domain-containing ion transport regulator 4 precursor","88","This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. [provided by RefSeq, Jul 2008]. "
5648,5651c5588
< "Q9D6X5-1","NP_081448.2","solute carrier family 52, riboflavin transporter, member 3 isoform 1 precursor","460",""
< "Q6PHN7-1","NP_808260.2","transmembrane protein 164 isoform a","296",""
< "Q9CPX9-1","NP_079665.1","anaphase-promoting complex subunit 11","84",""
< "A2AED3-1","NP_796065.2","fibronectin type III domain-containing protein 7 isoform 1 precursor","737",""
---
> "Q80Y50-1","NP_001177305.1","calmodulin-binding transcription activator 2 isoform 2","1203",""
5655c5592
< "Q9CR22-1","NP_079615.1","transmembrane protein 42 isoform 1","157",""
---
> "Q9CXT7-1","NP_001157219.1","transmembrane protein 192 isoform 2","221",""
5660d5596
< "Q3U1V8-1","NP_796369.2","mitogen-activated protein kinase kinase kinase 9 isoform 2","608",""
5663a5600
> "Q5HZI2-1","NP_001162095.1","C2 calcium-dependent domain-containing protein 4C","419",""
5668a5606
> "Q8CIG0-1","NP_001165563.1","DEP domain-containing protein 1A isoform 1","806",""
5670a5609
> "Q9ES64-1","NP_001157205.1","harmonin isoform b4","891",""
5672a5612
> "Q9CPV0-1","NP_080114.1","transmembrane protein 107 isoform 1","140",""
5674d5613
< "Q6PFY8-1","NP_919324.2","tripartite motif-containing protein 45 isoform b","580",""
5677,5678c5616
< "Q9D883-1","NP_077149.2","splicing factor U2AF 35 kDa subunit isoform 1","239",""
< "Q8BWR4-1","NP_001185502.1","ubiquitin carboxyl-terminal hydrolase 40 isoform 1","1235",""
---
> "Q7TPB0-1","NP_001164406.1","phospholipid phosphatase-related protein type 3 isoform 2","454",""
5689d5626
< "Q8BGC1-1","NP_084274.1","UPF0489 protein C5orf22 homolog isoform b","442",""
5691,5693c5628
< "Q6PE87-1","NP_081317.4","cilia- and flagella-associated protein 206 isoform 2","504",""
< "Q91V16-1","NP_598449.1","electron transfer flavoprotein regulatory factor 1","86",""
< "Q9D9J2-1","NP_082798.1","testis-expressed protein 33 isoform 1","266",""
---
> "Q3V0M2-1","NP_001028543.1","leucine-rich repeat-containing protein 36 isoform 3","634",""
5696d5630
< "P70303-1","NP_061207.1","CTP synthase 2 isoform a","586",""
5698a5633,5636
> "Q9CXX9-1","NP_001157762.1","CUE domain-containing protein 2 isoform a","284",""
> "Q3U108-1","NP_001165676.1","AT-rich interactive domain-containing protein 5A isoform 1","590",""
> "Q91WD1-1","NP_001157554.1","DNA-directed RNA polymerase III subunit RPC4","398",""
> "Q8CBW4-1","NP_001177647.1","DDB1- and CUL4-associated factor 12-like protein 1","501",""
5700d5637
< "P60670-1","NP_955763.1","nuclear protein localization protein 4 homolog isoform B","576",""
5701a5639,5640
> "P51807-1","NP_001160099.1","dynein light chain Tctex-type 1F isoform 1","113",""
> "Q6GU68-1","NP_001182360.1","immunoglobulin superfamily containing leucine-rich repeat protein precursor","428",""
5709d5647
< "Q8QZV4-1","NP_067277.2","serine/threonine-protein kinase 32C isoform 1","488",""
5710a5649
> "Q6P1E8-1","NP_001155100.1","EF-hand calcium-binding domain-containing protein 6 isoform 2","828",""
5714c5653,5654
< "Q80W71-1","NP_001157833.1","pleckstrin homology domain-containing family A member 8 isoform 1","519",""
---
> "Q8BX46-1","NP_001157227.1","SKI family transcriptional corepressor 1 isoform 2","936",""
> "Q5DU00-1","NP_001182546.1","doublecortin domain-containing protein 2 isoform 2","368","This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Sep 2010]. "
5716c5656
< "Q8R0P4-1","NP_899074.2","mth938 domain-containing protein isoform 2","122",""
---
> "A2AED3-1","NP_001159437.1","fibronectin type III domain-containing protein 7 isoform 2 precursor","651",""
5718a5659
> "Q8BMZ5-1","NP_001157676.1","tRNA-splicing endonuclease subunit Sen34 isoform a","316",""
5720c5661,5662
< "Q3U1D0-1","NP_690028.2","protein Lines homolog 1 isoform 1","764",""
---
> "Q91V61-1","NP_001171483.1","sideroflexin-3 isoform 2","288",""
> "Q4FJU9-1","NP_001161728.1","transmembrane protein 40 isoform a","225",""
5722d5663
< "Q8BL65-1","NP_808346.3","actin-binding LIM protein 2 isoform 3","612",""
5724c5665,5666
< "Q99K28-1","NP_076343.2","ADP-ribosylation factor GTPase-activating protein 2 isoform 2","520","This gene encodes a zinc-finger-containing GTPase-activating protein for ADP ribosylation factor 1 (ARF1), a small GTPase that plays a role in coatomer-mediated vesicular trafficking. This gene product stimulates the hydrolysis of ARF1-bound GTP, which may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. It may regulate the retrograde transport from the Golgi complex to the endoplasmic reticulum. Expression of this gene has been shown to be controlled by inhibitor of DNA binding 1 (Id1). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 6. [provided by RefSeq, Oct 2009]. "
---
> "Q8BLF2-1","NP_001160125.1","cyclin-dependent kinase-like 3 isoform 1","610",""
> "Q91V16-1","NP_001157100.1","electron transfer flavoprotein regulatory factor 1","86",""
5728,5730d5669
< "Q8QZR7-1","NP_666268.1","serine/threonine-protein kinase PDIK1L","341",""
< "Q9D4V3-1","NP_899116.1","coiled-coil domain-containing protein 83 isoform 1","408",""
< "Q3V0M2-1","NP_001164260.1","leucine-rich repeat-containing protein 36 isoform 2","636",""
5731a5671
> "Q8BGT8-1","NP_001156318.1","phytanoyl-CoA hydroxylase-interacting protein-like isoform 2","330",""
5733c5673
< "Q8VE88-1","NP_080618.1","protein FAM114A2 isoform 2","490",""
---
> "Q8BGC1-1","NP_001159832.1","UPF0489 protein C5orf22 homolog isoform a","126",""
5738a5679
> "Q8BK48-1","NP_001157228.1","pyrethroid hydrolase Ces2e precursor","559",""
5740c5681
< "O35698-1","NP_035383.2","RNA-binding motif protein, Y chromosome, family 1 member A1","380",""
---
> "P28310-1","NP_001161262.1","alpha-defensin 17 preproprotein","93",""
5743c5684
< "Q8C3X2-1","NP_079791.2","coiled-coil domain-containing protein 90B, mitochondrial isoform 1","256",""
---
> "Q8BUE4-1","NP_001034283.1","apoptosis-inducing factor 2 isoform 2","373",""
5745,5746d5685
< "Q8CI32-1","NP_081680.1","BAG family molecular chaperone regulator 5","447",""
< "P62313-1","NP_084421.1","U6 snRNA-associated Sm-like protein LSm6","80",""
5748,5749d5686
< "C0HK80-1","NP_084099.1","adipocyte-related X-chromosome expressed sequence 2","180",""
< "Q8K2Q2-1","NP_084327.1","glutathione S-transferase omega-2","248",""
5756d5692
< "Q8K2Z8-1","NP_850931.2","ubiquitin-conjugating enzyme E2 Q2 isoform 1","378",""
5758,5759c5694,5695
< "Q9CQL1-1","NP_079840.2","protein mago nashi homolog 2 isoform 1","148",""
< "Q9D1H7-1","NP_080545.2","Golgi to ER traffic protein 4 homolog isoform 1","327",""
---
> "Q9D2X5-1","NP_001161411.1","MAU2 chromatid cohesion factor homolog isoform 1","650",""
> "Q8BPY9-1","NP_001156831.1","fidgetin-like protein 1","683",""
5763d5698
< "Q91V76-1","NP_598493.1","ester hydrolase C11orf54 homolog isoform 1","315",""
5766c5701
< "Q8QZX5-1","NP_620046.1","U7 snRNA-associated Sm-like protein LSm10","122",""
---
> "Q8CGM1-1","NP_001186625.1","adhesion G protein-coupled receptor B2 isoform 2 precursor","1506",""
5768c5703
< "Q2KHK6-1","NP_808580.2","gasdermin-C2","480",""
---
> "Q80W71-1","NP_001001335.1","pleckstrin homology domain-containing family A member 8 isoform 2","474",""
5771d5705
< "Q8BKD6-1","NP_666154.3","E3 ubiquitin-protein ligase RNF144B","301",""
5774d5707
< "Q8R3A2-1","NP_932115.2","cysteine-rich DPF motif domain-containing protein 1","119",""
5776a5710
> "Q8BYN5-1","NP_001182213.1","FSD1-like protein isoform 1","497",""
5778d5711
< "Q8BK48-1","NP_766347.1","pyrethroid hydrolase Ces2e precursor","559",""
5781d5713
< "Q9DAK8-1","NP_081329.1","leucine-rich repeat-containing protein 51 isoform 1","192",""
5783,5784c5715
< "Q0P5X1-1","NP_083410.1","leucine-rich repeat and IQ domain-containing protein 1 isoform 2","814",""
< "C0HKC8-1","NP_001162073.1","sperm motility kinase 3A","504",""
---
> "Q9D1H0-1","NP_083372.1","RBPJ-interacting and tubulin-associated protein 1","253",""
5789,5790d5719
< "Q8BPY9-1","NP_068691.2","fidgetin-like protein 1","683",""
< "Q9DBA6-1","NP_082188.1","peroxisomal leader peptide-processing protease isoform a","568","This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]. "
5793c5722,5723
< "Q8BTV2-1","NP_758506.3","cleavage and polyadenylation specificity factor subunit 7 isoform 1","471",""
---
> "Q9D0L8-1","NP_001164424.1","mRNA cap guanine-N7 methyltransferase isoform 2","410",""
> "Q6PHN7-1","NP_001186289.1","transmembrane protein 164 isoform a","296",""
5798a5729
> "Q8BTE5-1","NP_001170873.1","protein CEBPZOS","80",""
5802,5803d5732
< "A7E1Z1-1","NP_796149.2","transmembrane protein 215","235",""
< "Q8C0R0-1","NP_795946.2","ubiquitin carboxyl-terminal hydrolase 37 isoform 1","979",""
5805c5734
< "Q9CQW0-1","NP_079594.1","ER membrane protein complex subunit 6","110",""
---
> "Q9CQ20-1","NP_001160107.1","mid1-interacting protein 1","182",""
5806a5736
> "Q9QZ15-1","NP_001163803.1","C-type lectin domain family 4 member A isoform b","238",""
5809,5812c5739
< "Q8BWL5-1","NP_848775.2","RNA-binding motif, single-stranded-interacting protein 3 isoform 3","414",""
< "Q8CGA3-1","NP_775564.1","large neutral amino acids transporter small subunit 4","568",""
< "Q9CQJ5-1","NP_079661.1","proline-rich protein 13","137",""
< "Q8BZM1-1","NP_573511.2","glomulin isoform a","596",""
---
> "Q3U0L2-1","NP_001157913.1","ankyrin repeat domain-containing protein 33B isoform 3","486",""
5817,5818c5744,5745
< "Q3UDK1-1","NP_758479.2","TRAF-type zinc finger domain-containing protein 1 isoform 2","576",""
< "Q9CPV0-1","NP_082612.2","transmembrane protein 107 isoform 2","143",""
---
> "P0C8K7-1","NP_001157193.1","small integral membrane protein 1","78",""
> "Q3UDK1-1","NP_001156942.1","TRAF-type zinc finger domain-containing protein 1 isoform 1","580",""
5822a5750
> "Q8BGF6-1","NP_001164162.1","ELMO domain-containing protein 2","293",""
5829a5758,5759
> "Q99KX1-1","NP_001163812.1","myeloid leukemia factor 2","247",""
> "Q9DCT6-1","NP_001171072.1","chromatin complexes subunit BAP18 isoform 1","191",""
5830a5761
> "Q9DAA3-1","NP_001157022.1","uncharacterized protein C4orf36 homolog","117",""
5832,5835c5763,5765
< "Q7TNE3-1","NP_766149.2","sperm-associated antigen 7 isoform 1","227",""
< "P59999-1","NP_080828.1","actin-related protein 2/3 complex subunit 4 isoform 1","168",""
< "Q91V61-1","NP_444427.1","sideroflexin-3 isoform 1","321",""
< "Q8BXT9-1","NP_848792.2","vesicle-trafficking protein SEC22c","303",""
---
> "Q8VE88-1","NP_001162138.1","protein FAM114A2 isoform 2","490",""
> "A7E1Z1-1","NP_001159481.1","transmembrane protein 215","235",""
> "Q9D956-1","NP_082860.2","MARVEL domain-containing protein 3 isoform a","376",""
5837c5767,5768
< "Q9Z2Q2-1","NP_075686.2","lysine-rich nucleolar protein 1 isoform 1","532",""
---
> "Q9D883-1","NP_001157241.1","splicing factor U2AF 35 kDa subunit isoform 2","239",""
> "Q8BQJ6-1","NP_001161466.1","tRNA (uracil(54)-C(5))-methyltransferase homolog isoform a","493",""
5840a5772,5773
> "Q3UN58-1","NP_001177374.1","Fanconi anemia core complex-associated protein 20 isoform a","186",""
> "Q99N08-1","NP_001159848.1","membrane-spanning 4-domains subfamily A member 6C isoform 2","120",""
5842a5776
> "O35698-1","NP_001159856.1","RNA-binding motif protein, Y chromosome, family 1 member A1","380",""
5844a5779
> "Q9CQJ5-1","NP_001164382.1","proline-rich protein 13","137",""
5850c5785
< "Q3TNH5-1","NP_612185.1","cotranscriptional regulator FAM172A isoform 1 precursor","417",""
---
> "Q6X786-1","NP_001159966.1","zona pellucida-binding protein 2 isoform 3","272",""
5851a5787
> "Q9R0Q4-1","NP_001161697.1","mortality factor 4-like protein 2","288",""
5853d5788
< "Q9CWD3-1","NP_084370.1","nucleoside diphosphate-linked moiety X motif 17 isoform 1","296",""
5856c5791
< "Q9D0U1-1","NP_081130.1","DTW domain-containing protein 2 isoform 1","298",""
---
> "Q8JZM6-1","NP_001162086.1","TRAF-interacting protein with FHA domain-containing protein B","147",""
5857a5793
> "Q8R079-1","NP_001171023.1","bifunctional apoptosis regulator isoform 2","325",""
5859d5794
< "Q810I0-1","NP_808242.1","vacuolar protein sorting-associated protein 37D isoform 2","176",""
5862d5796
< "Q80WG7-1","NP_849203.2","E3 ubiquitin-protein ligase Trim36 isoform 1","729",""
5863a5798
> "Q45VN2-1","NP_001170992.1","predicted gene 15308 precursor","95",""
5865,5866c5800
< "Q9D0L8-1","NP_080716.1","mRNA cap guanine-N7 methyltransferase isoform 1","465",""
< "Q3TNA1-1","NP_001186497.1","xylulose kinase isoform 2","318",""
---
> "Q8QZR7-1","NP_001157266.1","serine/threonine-protein kinase PDIK1L","341",""
5867a5802
> "Q9D2Q8-1","NP_001156997.1","protein S100-A14 isoform a","104",""
5868a5804
> "Q9CQN3-1","NP_001158201.1","mitochondrial import receptor subunit TOM6 homolog","74",""
5873,5874c5809,5811
< "Q8BGF6-1","NP_848851.3","ELMO domain-containing protein 2","293",""
< "Q99KN1-1","NP_848495.2","arrestin domain-containing protein 1 isoform b","433",""
---
> "Q5HZH2-1","NP_001157190.1","ribosome biogenesis protein TSR3 homolog isoform 2","316",""
> "Q9QYK9-1","NP_001186280.1","calcium/calmodulin-dependent protein kinase type 1B","343",""
> "Q9CZY2-1","NP_001162050.1","transcription elongation factor A protein-like 8","117",""
5878d5814
< "Q8K2D6-1","NP_848903.2","deoxycytidylate deaminase","184",""
5881d5816
< "Q5G866-1","NP_031874.2","alpha-defensin-related sequence 7 precursor","93",""
5884d5818
< "B2B9E1-1","NP_776107.2","triple QxxK/R motif-containing protein","86",""
5885a5820,5821
> "Q6NXY1-1","NP_001074865.2","TBC1 domain family member 31 isoform 1","996",""
> "Q9D5I4-1","NP_001157239.1","tctex1 domain-containing protein 1 isoform 1","173",""
5887a5824
> "Q9DBX3-1","NP_001156385.1","sushi domain-containing protein 2 isoform 2 precursor","700",""
5889,5890c5826,5828
< "Q8BT14-1","NP_058573.3","CCR4-NOT transcription complex subunit 4 isoform 2","575",""
< "Q9CRW3-1","NP_082715.1","UPF0538 protein C2orf76 homolog isoform 1","126",""
---
> "Q8BT14-1","NP_001157883.1","CCR4-NOT transcription complex subunit 4 isoform 3","572",""
> "Q9D0U1-1","NP_001164431.1","DTW domain-containing protein 2 isoform 2","202",""
> "Q810A5-1","NP_001159866.1","uncharacterized protein KIAA0895-like","467",""
5891a5830
> "Q9D541-1","NP_001183970.1","coiled-coil domain-containing protein 7 isoform 2","160",""
5893a5833
> "Q60936-1","NP_001156762.1","atypical kinase COQ8A, mitochondrial isoform 1","645",""
5897c5837
< "Q9D2X5-1","NP_083269.4","MAU2 chromatid cohesion factor homolog isoform 2","618",""
---
> "Q3V1L4-1","NP_001157835.1","cytosolic purine 5'-nucleotidase isoform 1","586",""
5901,5902c5841
< "Q8BLF2-1","NP_722480.3","cyclin-dependent kinase-like 3 isoform 2","595",""
< "Q80WR5-1","NP_780496.2","UPF0688 protein C1orf174 homolog isoform 1","230",""
---
> "Q8QZX5-1","NP_001156738.1","U7 snRNA-associated Sm-like protein LSm10","122",""
5904a5844
> "Q80ZQ5-1","NP_001161749.1","juxtaposed with another zinc finger protein 1 isoform 2","179",""
5908c5848
< "Q80ZQ5-1","NP_775582.2","juxtaposed with another zinc finger protein 1 isoform 1","243",""
---
> "Q9D4G9-1","NP_001161720.1","recQ-mediated genome instability protein 1","616",""
5913d5852
< "Q60936-1","NP_075830.2","atypical kinase COQ8A, mitochondrial isoform 1","645",""
5916d5854
< "Q8R079-1","NP_080252.1","bifunctional apoptosis regulator isoform 1","450",""
5918d5855
< "Q9CQN3-1","NP_079641.1","mitochondrial import receptor subunit TOM6 homolog","74",""
5922c5859,5860
< "Q9D956-1","NP_997612.2","MARVEL domain-containing protein 3 isoform b","385",""
---
> "Q9CQW0-1","NP_001161942.1","ER membrane protein complex subunit 6","110",""
> "Q6GQT0-1","NP_001074287.1","dual specificity protein phosphatase CDC14A isoform 1","603",""
5925c5863,5865
< "Q9QYK9-1","NP_036170.1","calcium/calmodulin-dependent protein kinase type 1B","343",""
---
> "Q8BLD6-1","NP_001161875.1","ankyrin repeat domain-containing protein 55 isoform 2","598",""
> "Q6NZE7-1","NP_001159837.2","protein FAM122B isoform 1","255",""
> "Q9D1H7-1","NP_001156788.1","Golgi to ER traffic protein 4 homolog isoform 2","274",""
5927c5867,5868
< "Q9DAA3-1","NP_083100.1","uncharacterized protein C4orf36 homolog","117",""
---
> "Q9D306-1","NP_001155840.1","alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C","478",""
> "Q8BMD7-1","NP_001180238.1","MORC family CW-type zinc finger protein 4 isoform A","928",""
5928a5870
> "Q8BMD5-1","NP_001162007.1","cytidine and dCMP deaminase domain-containing protein 1 isoform 1","525",""
5931c5873
< "Q8BR26-1","NP_796239.1","interferon-induced transmembrane protein 10 isoform 2","162",""
---
> "Q9CQK8-1","NP_001158259.1","small proline-rich protein 2A2","83",""
5934c5876
< "Q9DCD5-1","NP_083027.1","tight junction-associated protein 1","539",""
---
> "Q08EC4-1","NP_001074289.1","cas scaffolding protein family member 4 isoform 2","804",""
5937d5878
< "Q8R5K2-1","NP_573510.2","ubiquitin carboxyl-terminal hydrolase 33 isoform 1","909",""
5939d5879
< "D2J0Y4-1","NP_001186870.1","(E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 1","691",""
5948,5949d5887
< "Q9CR30-1","NP_079644.1","josephin-2 isoform a","188",""
< "Q8BSP2-1","NP_001258530.1","condensin-2 complex subunit H2 isoform c","608","This gene encodes a component of the condensin-2 complex. The encoded protein may regulate the structure of mitotic chromosomes. Loss of function of this gene disrupts T-cell development. There are two pseudogenes for this gene on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]. "
5951a5890
> "Q8K1N2-1","NP_001239371.1","pleckstrin homology-like domain family B member 2 isoform 1","1302",""
5956a5896
> "Q3UUJ4-1","NP_001239377.1","STE20-related kinase adapter protein alpha isoform 1","431",""
5958c5898
< "Q8R2Q4-1","NP_796240.3","ribosome-releasing factor 2, mitochondrial isoform 1","779",""
---
> "Q8BK03-1","NP_001229336.1","mitoguardin 2","593",""
5970c5910
< "Q14AT5-1","NP_996914.1","anoctamin-7 isoform 1","859","This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to have little anion conductance activity. In humans, this protein is primarily found in prostate tissues and may serve as a target for prostate cancer immunotherapy. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Dec 2012]. "
---
> "Q8R4V1-1","NP_001258340.1","NFAT activation molecule 1 isoform a precursor","264",""
5974d5913
< "Q3UUJ4-1","NP_082402.1","STE20-related kinase adapter protein alpha isoform 2","394",""
5981d5919
< "Q3TVA9-1","NP_663549.3","coiled-coil domain-containing protein 136 isoform 1","1002",""
5983a5922
> "Q8BSL4-1","NP_001074677.1","heparan sulfate glucosamine 3-O-sulfotransferase 5","346",""
5988c5927,5928
< "Q99LH4-1","NP_848876.2","zinc finger protein 672","468",""
---
> "A2AHC3-1","NP_001263288.1","calmodulin-regulated spectrin-associated protein 1 isoform 1","1582",""
> "Q8C3R1-1","NP_001263216.1","BRCA1-associated ATM activator 1 isoform 3","867","A similar gene in human encodes a Breast Cancer 1 (BRCA1) interacting protein that is involved in cell cycle checkpoint signaling. The similar human protein is localized to DNA double strand breaks caused by ionizing radiation, and regulates cellular DNA damage response through interactions with Ataxia Telangiectasia Mutated (ATM) and DNA-dependent Protein Kinase. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
5990,5991d5929
< "Q5XKN4-1","NP_080641.1","protein jagunal homolog 1 isoform 1","183",""
< "Q8K1J6-1","NP_081572.1","CCA tRNA nucleotidyltransferase 1, mitochondrial isoform a","434",""
5994c5932
< "Q3TYS2-1","NP_659081.1","cytochrome b-245 chaperone 1 isoform 1","187",""
---
> "Q08AU7-1","NP_001191749.1","myeloid-associated differentiation marker-like protein 2 isoform 2","153",""
5999a5938,5939
> "Q8CJ19-1","NP_001257404.1","[F-actin]-monooxygenase MICAL3 isoform 1","1993",""
> "O35453-1","NP_001103722.1","serine protease hepsin isoform 1 precursor","436","This gene encodes a type II transmembrane serine protease that may function in diverse processes, including regulation of cell growth. Deficiency in this gene results in hearing loss. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]. "
6004d5943
< "Q8BSL4-1","NP_001240285.1","heparan sulfate glucosamine 3-O-sulfotransferase 5","346",""
6006a5946
> "Q3UBZ5-1","NP_001230513.1","MIF4G domain-containing protein isoform 1","222",""
6008a5949
> "Q8BG16-1","NP_001239259.1","sodium-dependent neutral amino acid transporter B(0)AT2","729",""
6011d5951
< "Q8BWG4-1","NP_808325.2","uncharacterized protein KIAA1755 homolog isoform 1","1187",""
6022d5961
< "Q8C3R1-1","NP_851411.1","BRCA1-associated ATM activator 1 isoform 2","822","A similar gene in human encodes a Breast Cancer 1 (BRCA1) interacting protein that is involved in cell cycle checkpoint signaling. The similar human protein is localized to DNA double strand breaks caused by ionizing radiation, and regulates cellular DNA damage response through interactions with Ataxia Telangiectasia Mutated (ATM) and DNA-dependent Protein Kinase. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
6024d5962
< "Q149M0-1","NP_081985.1","C-type lectin domain family 12 member B","275",""
6027a5966,5967
> "Q9D9J2-1","NP_001157084.1","testis-expressed protein 33 isoform 1","266",""
> "Q99LP8-1","NP_001192086.1","protein YIPF2","312",""
6035a5976
> "Q9JJT2-1","NP_001129535.1","GDNF family receptor alpha-4 isoform 1 precursor","293","This gene encodes a transmembrane protein that functions as the receptor for persephin, a member of the glial cell line derived neurotrophic factors. The encoded protein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-anchored cell surface coreceptor that forms a complex with the receptor tyrosine kinase Ret. A complete lack of the encoded protein impairs production of thyroid calcitonin and increases the rate of bone formation in young mice. [provided by RefSeq, Jul 2016]. "
6038,6039c5979
< "Q8BVF4-1","NP_083562.1","coiled-coil domain-containing protein 30 isoform a","654",""
< "Q91VJ5-1","NP_062351.2","polyglutamine-binding protein 1 isoform 1","263",""
---
> "Q3KNK3-1","NP_001192156.1","NADH-cytochrome b5 reductase 2 isoform 1","292",""
6042d5981
< "Q8C0P5-1","NP_849224.2","coronin-2A isoform 1","543",""
6043a5983
> "Q3TZM9-1","NP_001230090.1","GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase isoform 1","492",""
6044a5985,5986
> "Q9D0K0-1","NP_001239568.1","TBC1 domain family member 7 isoform 1","293",""
> "Q9D787-1","NP_001239373.1","RING-type E3 ubiquitin-protein ligase PPIL2 isoform 1","521",""
6048c5990,5991
< "Q9JIY8-1","NP_001188318.1","camello-like 3-like","226",""
---
> "Q8VCD6-1","NP_001191843.1","receptor expression-enhancing protein 2 isoform 2","252",""
> "Q9JM62-1","NP_001191860.1","receptor expression-enhancing protein 6 isoform 2","174",""
6056d5998
< "Q9CYI4-1","NP_082466.2","putative RNA-binding protein Luc7-like 1 isoform 2","371",""
6061d6002
< "Q4V9Z5-1","NP_659175.1","seizure 6-like protein 2 isoform 1 precursor","923",""
6063,6064d6003
< "A2AHC3-1","NP_001263290.1","calmodulin-regulated spectrin-associated protein 1 isoform 3","1602",""
< "Q9JM62-1","NP_647453.1","receptor expression-enhancing protein 6 isoform 1","201",""
6066d6004
< "Q8VI16-1","NP_849210.1","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 precursor","399",""
6067a6006
> "Q9D823-1","NP_001258519.1","60S ribosomal protein L37","97",""
6069a6009
> "Q8BKV0-1","NP_001239549.1","testican-3 isoform 1 precursor","436",""
6074d6013
< "Q9CWE0-1","NP_084035.1","mitochondrial fission regulator 1-like","289",""
6076a6016
> "Q91VV4-1","NP_001087223.1","DENN domain-containing protein 2D isoform 2","466",""
6079a6020
> "Q5U4E2-1","NP_001073370.2","replication initiator 1 isoform a","598",""
6081a6023
> "Q99KP6-1","NP_001240772.1","pre-mRNA-processing factor 19 isoform 1","523",""
6086d6027
< "Q8R4V1-1","NP_083004.1","NFAT activation molecule 1 isoform d","224",""
6090d6030
< "B2RRE7-1","NP_001242962.1","OTU domain-containing protein 4 isoform 1","1107",""
6094c6034
< "Q8K1N2-1","NP_700461.2","pleckstrin homology-like domain family B member 2 isoform 2","1249",""
---
> "Q8K4P7-1","NP_001240631.1","suppressor of tumorigenicity 7 protein-like isoform 2","527",""
6097,6098c6037
< "Q9D7G4-1","NP_080243.3","protein EURL homolog","290",""
< "Q91XE8-1","NP_848692.2","transmembrane protein 205 isoform 2","189",""
---
> "Q6PKN7-1","NP_001239411.1","protein INCA1 isoform 1","231",""
6100c6039,6040
< "Q8BKV0-1","NP_076178.1","testican-3 isoform 1 precursor","436",""
---
> "Q9CR30-1","NP_001191999.1","josephin-2 isoform a","188",""
> "Q6PE15-1","NP_001258999.1","mycophenolic acid acyl-glucuronide esterase, mitochondrial isoform 2 precursor","292","This gene encodes a mitochondrially-localized enzyme that acts as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There are two pseudogenes for this gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
6105a6046
> "Q8VI16-1","NP_001258844.1","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 precursor","399",""
6111a6053
> "Q9D7G4-1","NP_001239367.1","protein EURL homolog","290",""
6124d6065
< "Q8BH79-1","NP_598740.1","anoctamin-10 isoform 1","659","This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to inhibit anion conductance. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Dec 2012]. "
6127a6069
> "Q91VJ5-1","NP_001239457.1","polyglutamine-binding protein 1 isoform 1","263",""
6136a6079
> "Q80ZM3-1","NP_001239023.1","electron transfer flavoprotein beta subunit lysine methyltransferase isoform a","255",""
6140d6082
< "Q3TVP5-1","NP_938043.1","inactive ubiquitin thioesterase OTULINL isoform 3","303",""
6142a6085
> "Q14AT5-1","NP_001258813.1","anoctamin-7 isoform 2","843","This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to have little anion conductance activity. In humans, this protein is primarily found in prostate tissues and may serve as a target for prostate cancer immunotherapy. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Dec 2012]. "
6144d6086
< "Q8K0H7-1","NP_666089.1","solute carrier family 45 member 3","553",""
6147,6148d6088
< "Q99LP8-1","NP_612176.1","protein YIPF2","312",""
< "Q9D3S3-1","NP_083240.2","sorting nexin-29 isoform a","818",""
6150a6091
> "Q9CYI4-1","NP_080157.1","putative RNA-binding protein Luc7-like 1 isoform 1","325",""
6152a6094
> "Q8R2V2-1","NP_001192102.1","intermediate filament family orphan 2 isoform 1","512",""
6156c6098
< "Q3U285-1","NP_835278.2","ligand-dependent nuclear receptor corepressor-like protein isoform 3","315",""
---
> "Q3TYS2-1","NP_001239477.1","cytochrome b-245 chaperone 1 isoform 1","187",""
6159a6102,6103
> "Q8K0H7-1","NP_001171099.1","solute carrier family 45 member 3","553",""
> "Q9CZ00-1","NP_001164446.2","dysbindin domain-containing protein 1 isoform 2","147",""
6163a6108
> "Q8R2Q4-1","NP_001139515.1","ribosome-releasing factor 2, mitochondrial isoform 2","741",""
6166a6112
> "Q8BSP2-1","NP_001108604.1","condensin-2 complex subunit H2 isoform a","607","This gene encodes a component of the condensin-2 complex. The encoded protein may regulate the structure of mitotic chromosomes. Loss of function of this gene disrupts T-cell development. There are two pseudogenes for this gene on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]. "
6170d6115
< "Q9JJC8-1","NP_076136.2","magnesium transporter NIPA2 isoform 1","359",""
6171a6117
> "Q9DCD5-1","NP_001239402.1","tight junction-associated protein 1","539",""
6174a6121
> "Q9D411-1","NP_001240818.1","testis-specific serine/threonine-protein kinase 4 isoform 4","292",""
6178c6125
< "Q8VDS7-3","NP_001230004.1","centrosomal protein CEP57L1 isoform 4","379",""
---
> "Q91XE8-1","NP_001240797.1","transmembrane protein 205 isoform 2","189",""
6182a6130
> "Q3U2E2-1","NP_001240681.1","zinc finger MYM-type protein 5","627",""
6184a6133,6136
> "Q9D9W1-1","NP_001186957.1","protein pitchfork isoform a","246",""
> "Q149M0-1","NP_001191152.1","C-type lectin domain family 12 member B","275",""
> "Q18PI6-1","NP_001239401.1","SLAM family member 5 isoform 2 precursor","140",""
> "P97435-1","NP_032967.1","enteropeptidase isoform 1 precursor","1069","This gene encodes an enzyme that proteolytically activates the pancreatic proenzyme trypsinogen, converting it into trypsin. The encoded protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]. "
6188d6139
< "Q80ZM3-1","NP_796075.2","electron transfer flavoprotein beta subunit lysine methyltransferase isoform a","255",""
6189a6141
> "Q8BWG4-1","NP_001124493.1","uncharacterized protein KIAA1755 homolog isoform 2","1106",""
6192d6143
< "Q3KNK3-1","NP_796190.1","NADH-cytochrome b5 reductase 2 isoform 2","276",""
6195d6145
< "Q9D787-1","NP_659203.1","RING-type E3 ubiquitin-protein ligase PPIL2 isoform 1","521",""
6197d6146
< "Q9CXP4-1","NP_082731.2","rho GTPase-activating protein 8","425",""
6201c6150
< "Q8BG16-1","NP_780537.1","sodium-dependent neutral amino acid transporter B(0)AT2","729",""
---
> "Q61121-1","NP_001161166.1","probable G-protein coupled receptor 19 isoform a","415",""
6203d6151
< "Q8VCD6-1","NP_659114.2","receptor expression-enhancing protein 2 isoform 1","254",""
6206d6153
< "Q8VCX2-1","NP_659142.1","solute carrier family 35 member C2 isoform 1","364",""
6209d6155
< "Q6PE15-1","NP_766099.3","mycophenolic acid acyl-glucuronide esterase, mitochondrial isoform 1 precursor","297","This gene encodes a mitochondrially-localized enzyme that acts as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There are two pseudogenes for this gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
6211a6158
> "Q8BG21-1","NP_001230168.1","calcium channel flower homolog isoform 2","128",""
6215c6162
< "Q3U2I3-1","NP_950174.1","FTS and Hook-interacting protein isoform a","975",""
---
> "Q9DB32-1","NP_001258362.1","hydroxyacylglutathione hydrolase-like protein isoform a","283",""
6217c6164,6166
< "Q9Z1K8-1","NP_035535.2","Y+L amino acid transporter 1","510",""
---
> "Q3U2I3-1","NP_001229292.1","FTS and Hook-interacting protein isoform a","975",""
> "Q80VP8-1","NP_001239082.1","transmembrane protein 106C","260",""
> "Q91YP6-1","NP_001240621.1","ELMO domain-containing protein 3","381",""
6220d6168
< "Q62252-1","NP_035579.1","sperm surface protein Sp17","149",""
6234d6181
< "Q9D0K0-1","NP_080211.1","TBC1 domain family member 7 isoform 1","293",""
6235a6183
> "Q8K114-1","NP_001240660.1","integrator complex subunit 9 isoform 2","634",""
6241a6190
> "Q3TVA9-1","NP_001188307.1","coiled-coil domain-containing protein 136 isoform 2","908",""
6245c6194
< "Q8CJ19-1","NP_700445.2","[F-actin]-monooxygenase MICAL3 isoform 2","864",""
---
> "Q8R5K2-1","NP_001239415.1","ubiquitin carboxyl-terminal hydrolase 33 isoform 3","901",""
6250d6198
< "Q8K4P7-1","NP_694731.1","suppressor of tumorigenicity 7 protein-like isoform 1","559",""
6254a6203
> "Q8K1J6-1","NP_001229287.1","CCA tRNA nucleotidyltransferase 1, mitochondrial isoform a","434",""
6256a6206,6207
> "Q9CZD5-1","NP_001243029.1","translation initiation factor IF-3, mitochondrial","276",""
> "Q9JJC8-1","NP_001243059.1","magnesium transporter NIPA2 isoform 1","359",""
6260c6211
< "Q91YP6-1","NP_659166.1","ELMO domain-containing protein 3","381",""
---
> "Q8VDQ1-1","NP_001239554.1","prostaglandin reductase 2 isoform 1","351",""
6263d6213
< "Q99KP6-1","NP_598890.1","pre-mRNA-processing factor 19 isoform 2","504",""
6265a6216
> "Q9DBA6-1","NP_001259019.1","peroxisomal leader peptide-processing protease isoform b","521","This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]. "
6267a6219
> "Q9Z1K8-1","NP_001240608.1","Y+L amino acid transporter 1","510",""
6271d6222
< "Q9CZ00-1","NP_082422.3","dysbindin domain-containing protein 1 isoform 1","194",""
6272a6224
> "Q8BKE5-1","NP_001243071.1","fibrinogen silencer-binding protein","299",""
6274a6227
> "Q8VCX2-1","NP_001239502.1","solute carrier family 35 member C2 isoform 1","364",""
6284d6236
< "Q9DB32-1","NP_081173.1","hydroxyacylglutathione hydrolase-like protein isoform a","283",""
6289a6242
> "Q8R070-1","NP_001229356.1","glucose-6-phosphate exchanger SLC37A1","531",""
6291d6243
< "Q61121-1","NP_032183.2","probable G-protein coupled receptor 19 isoform b","409",""
6292a6245
> "Q5XKN4-1","NP_001230668.1","protein jagunal homolog 1 isoform 3","67",""
6294a6248
> "Q4V9Z5-1","NP_001239495.1","seizure 6-like protein 2 isoform 2 precursor","910",""
6300a6255
> "Q8BI36-1","NP_001191996.1","JNK1/MAPK8-associated membrane protein isoform 2","305",""
6306c6261
< "Q3TLP5-1","NP_081004.2","enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform 1 precursor","296",""
---
> "Q3TLP5-1","NP_001241683.1","enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform 2","191",""
6312d6266
< "Q8BG21-1","NP_084138.1","calcium channel flower homolog isoform 1","171",""
6314d6267
< "Q8VDQ1-1","NP_084156.2","prostaglandin reductase 2 isoform 1","351",""
6318d6270
< "Q3TZM9-1","NP_898965.1","GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase isoform 2","450",""
6320d6271
< "Q80VP8-1","NP_958747.1","transmembrane protein 106C","260",""
6322c6273
< "Q08EC4-1","NP_001263352.1","cas scaffolding protein family member 4 isoform 4","778",""
---
> "Q8VDS7-3","NP_001230003.1","centrosomal protein CEP57L1 isoform 3","426",""
6324d6274
< "Q6P1F6-1","NP_082308.1","serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 1","447",""
6331d6280
< "P97435-1","NP_849186.2","enteropeptidase isoform 2 precursor","1054","This gene encodes an enzyme that proteolytically activates the pancreatic proenzyme trypsinogen, converting it into trypsin. The encoded protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]. "
6337a6287,6288
> "Q8K2W3-1","NP_083858.1","thioredoxin domain-containing protein 11 isoform 1","948",""
> "Q8BM14-1","NP_001192278.1","lipase member K isoform 1 precursor","403",""
6339c6290,6291
< "Q8R2V2-1","NP_898971.1","intermediate filament family orphan 2 isoform 2","287",""
---
> "Q2TUM3-1","NP_001034194.1","potassium channel regulatory protein isoform 1","264",""
> "Q8R3C1-1","NP_001230670.1","uncharacterized protein C2orf42 homolog isoform 2","564",""
6341d6292
< "Q9CZD5-1","NP_083857.1","translation initiation factor IF-3, mitochondrial","276",""
6344a6296,6298
> "P59096-1","NP_001276577.1","stAR-related lipid transfer protein 6","233",""
> "Q9JIB0-1","NP_001272370.1","ran guanine nucleotide release factor isoform 1","193",""
> "Q9Z2L7-1","NP_001264035.1","cytokine receptor-like factor 3 isoform 2","344","This gene encodes a cytokine receptor-like factor that contains a fibronectin type 3 domain. The encoded protein may act as a negative regulator of the cell cycle. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. "
6348,6352c6302,6305
< "Q80ZJ6-1","NP_848809.2","protein zer-1 homolog isoform a","779",""
< "Q3U3F9-1","NP_082241.1","probable G-protein coupled receptor 160","336",""
< "Q7TT52-1","NP_082380.1","protein phosphatase 1 regulatory subunit 14D isoform b","146",""
< "A7XUX6-1","NP_001272894.1","selection and upkeep of intraepithelial T-cells protein 2 isoform b precursor","390",""
< "Q9DD02-1","NP_080580.1","protein Hikeshi isoform a","197",""
---
> "Q9DBZ5-1","NP_001272871.1","eukaryotic translation initiation factor 3 subunit K isoform 2","185",""
> "Q9D2L6-1","NP_001276428.1","adhesion G protein-coupled receptor F4 precursor","698",""
> "Q80ZJ6-1","NP_001277432.1","protein zer-1 homolog isoform b","766",""
> "Q8BW96-1","NP_001277303.1","calcium/calmodulin-dependent protein kinase type 1D isoform b","337",""
6354,6357c6307,6313
< "Q9ESC7-1","NP_075738.1","protein yippee-like 1 isoform 2","118",""
< "Q9DB26-1","NP_758471.1","phytanoyl-CoA dioxygenase domain-containing protein 1 isoform 1","311",""
< "Q8BP07-1","NP_796366.1","transmembrane protein 220 isoform 1 precursor","191",""
< "Q9D7I0-1","NP_080657.1","protein shisa-5 isoform 2","132",""
---
> "Q4FZC9-1","NP_001036164.1","nesprin-3 isoform alpha","975",""
> "A4QPC6-1","NP_001276544.1","butyrophilin subfamily 2 member A2 isoform 1 precursor","514",""
> "A2AR95-1","NP_001277713.1","low-density lipoprotein receptor class A domain-containing protein 3 isoform b precursor","344",""
> "Q8BW41-1","NP_001276487.1","protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 precursor","580",""
> "Q9EPR2-1","NP_075685.2","group XIIA secretory phospholipase A2 isoform 1 precursor","192",""
> "Q8BUM9-1","NP_001277978.1","ubiquitin carboxyl-terminal hydrolase 43 isoform 2","1127",""
> "Q8VEA6-1","NP_001278249.1","chordin-like protein 2 isoform 1","433",""
6360,6374c6316,6329
< "Q8BHA9-1","NP_700469.1","2-phosphoxylose phosphatase 1","480",""
< "Q5F2L2-1","NP_598922.1","alpha-(1,3)-fucosyltransferase 10 isoform b","436",""
< "Q99KC7-1","NP_778157.2","small cell adhesion glycoprotein isoform 1","97",""
< "Q3UQ22-1","NP_001276622.1","netrin-5 isoform c","383",""
< "Q8R5F3-1","NP_997102.2","ADP-ribose glycohydrolase OARD1","152",""
< "Q8BQC8-1","NP_067301.1","RB-associated KRAB zinc finger protein","711",""
< "Q8VDG7-1","NP_598641.2","platelet-activating factor acetylhydrolase 2, cytoplasmic isoform b","390",""
< "Q6PGA0-1","NP_659063.3","REST corepressor 3 isoform a","451",""
< "Q9R1R2-1","NP_061368.1","tripartite motif-containing protein 3 isoform a","744",""
< "Q8BN82-1","NP_766361.1","sialin isoform a","495",""
< "Q9CWP6-1","NP_084006.2","motile sperm domain-containing protein 2 isoform 1","518",""
< "Q8VC34-1","NP_659160.2","putative RNA polymerase II subunit B1 CTD phosphatase Rpap2 isoform A","614",""
< "P59096-1","NP_083295.1","stAR-related lipid transfer protein 6","233",""
< "Q9CZ44-1","NP_938085.1","NSFL1 cofactor p47 isoform a","372",""
< "Q6NZQ6-1","NP_001276624.1","zinc finger protein 740 isoform 4","180",""
---
> "Q91YT2-1","NP_001277401.1","E3 ubiquitin-protein ligase RNF185 isoform 2","192",""
> "Q3ULM0-1","NP_001277358.1","coiled-coil domain-containing protein 106 isoform a","341",""
> "A2AHG0-1","NP_001277956.1","leucine zipper putative tumor suppressor 3 isoform b","679",""
> "Q8R2T8-1","NP_001277413.1","general transcription factor 3C polypeptide 5 isoform a","520",""
> "Q3U1J1-1","NP_001277310.1","TCF3 fusion partner homolog isoform 1","259",""
> "Q99MS3-1","NP_001276491.1","mpv17-like protein isoform 3","96",""
> "Q9Z2H5-1","NP_001006665.1","band 4.1-like protein 1 isoform a","879",""
> "P59055-1","NP_001277594.1","cysteine/serine-rich nuclear protein 3 isoform b","585",""
> "Q8BKK4-1","NP_001277672.1","protein phosphatase 1 regulatory subunit 1C isoform b","91",""
> "Q8CDP0-1","NP_001276585.1","cytosolic carboxypeptidase 3 isoform 1","1006",""
> "Q8C4P0-1","NP_001015681.1","uncharacterized protein KIAA1958 homolog isoform 2","716",""
> "Q3UQV5-1","NP_001008785.2","kelch repeat and BTB domain-containing protein 8 isoform a","599",""
> "Q9D0Z3-1","NP_001272741.1","transmembrane protein 53 isoform a","283",""
> "Q6PGD0-1","NP_082131.2","all-trans retinoic acid-induced differentiation factor isoform 1 precursor","223",""
6376,6377c6331
< "Q9D6N5-1","NP_077138.1","dr1-associated corepressor isoform 2","205",""
< "Q6P1H1-1","NP_958739.1","cytochrome b ascorbate-dependent protein 3 isoform 1","242",""
---
> "Q8BG34-1","NP_001272857.1","UBX domain-containing protein 10","277",""
6379c6333,6334
< "Q9D818-1","NP_001277336.1","suppressor APC domain-containing protein 2 isoform b","391",""
---
> "Q99LW0-1","NP_001268903.1","ankyrin repeat domain-containing protein 10 isoform 3","232",""
> "Q8BG15-1","NP_001277920.1","CTD small phosphatase-like protein 2 isoform b","464",""
6381a6337
> "Q99N11-1","NP_001033044.1","dual specificity protein phosphatase 22 isoform a","205",""
6383c6339
< "Q9CQ89-1","NP_081224.1","protein CutA isoform 2 precursor","154",""
---
> "Q80VP5-1","NP_001128189.1","probable peptide chain release factor C12orf65 homolog, mitochondrial isoform a","184",""
6385c6341,6342
< "Q91ZJ5-1","NP_647458.1","UTP--glucose-1-phosphate uridylyltransferase isoform 1","508",""
---
> "Q8C033-1","NP_001032825.1","rho guanine nucleotide exchange factor 10 isoform b","1306",""
> "Q6R3M4-1","NP_001129562.1","DNA polymerase iota isoform 1","674",""
6386a6344,6345
> "Q6PE13-1","NP_001276629.1","proline-rich transmembrane protein 3 isoform a precursor","972",""
> "Q8C1M2-1","NP_001277390.1","zinc finger protein 428 isoform a","189",""
6388,6392c6347,6356
< "Q8BZ89-1","NP_766174.1","zinc finger protein 322","410",""
< "Q8C3M9-1","NP_780502.1","uncharacterized protein C2orf80 homolog isoform 1","231",""
< "Q8R2T8-1","NP_683730.1","general transcription factor 3C polypeptide 5 isoform b","514",""
< "Q91YT2-1","NP_663330.2","E3 ubiquitin-protein ligase RNF185 isoform 1","228",""
< "Q6NY15-1","NP_997111.1","testis-specific gene 10 protein isoform 1","697",""
---
> "Q8BXX9-1","NP_001277067.1","coiled-coil domain-containing protein 169 isoform b","132",""
> "Q925E8-1","NP_001157682.1","serine palmitoyltransferase small subunit B isoform a","76",""
> "Q9D3S3-1","NP_001277077.1","sorting nexin-29 isoform b","476",""
> "Q810L3-1","NP_001276506.1","E3 ubiquitin-protein ligase CHFR isoform 1","664",""
> "Q80YF9-1","NP_001276599.1","rho GTPase-activating protein 33 isoform b","1281",""
> "Q9D7W5-1","NP_001277617.1","mediator of RNA polymerase II transcription subunit 8 isoform 3","179",""
> "Q8BZ94-1","NP_001264168.1","zinc finger matrin-type protein 4 isoform 2","160",""
> "Q9D1R9-1","NP_001005859.1","60S ribosomal protein L34","117",""
> "Q8BSN5-1","NP_001278054.1","PHD finger protein 23 isoform b","334",""
> "A7XUX6-1","NP_001272892.1","selection and upkeep of intraepithelial T-cells protein 2 isoform a precursor","400",""
6394,6399c6358,6365
< "Q8CFQ3-1","NP_033832.2","RNA helicase aquarius isoform a","1481",""
< "Q8BP97-1","NP_796344.1","rhomboid domain-containing protein 3 isoform a","385",""
< "Q8C460-1","NP_536717.2","ERI1 exoribonuclease 3 isoform a","337",""
< "Q3TEA8-1","NP_034600.2","heterochromatin protein 1-binding protein 3 isoform 1","554",""
< "Q7TQ07-1","NP_862905.1","DNA polymerase nu isoform 1","866",""
< "Q6SJ95-1","NP_951014.1","TATA box-binding protein-like protein 2 isoform 1","350",""
---
> "Q3TEA8-1","NP_001116368.1","heterochromatin protein 1-binding protein 3 isoform 2","516",""
> "Q78YZ6-1","NP_001034226.1","short coiled-coil protein isoform a","125",""
> "Q91ZJ5-1","NP_001277563.1","UTP--glucose-1-phosphate uridylyltransferase isoform 2","497",""
> "Q8BHA9-1","NP_001276574.1","2-phosphoxylose phosphatase 1","480",""
> "Q8C4V1-1","NP_001273397.1","rho GTPase-activating protein 24 isoform 2","654",""
> "Q9CQ37-1","NP_001265044.1","ubiquitin-conjugating enzyme E2 T","204",""
> "Q3TJD7-1","NP_001107560.1","PDZ and LIM domain protein 7 isoform a","457",""
> "Q8VE91-4","NP_001030023.1","reticulophagy regulator 1 isoform 1","480",""
6401,6404c6367,6368
< "Q8BGP6-1","NP_848881.2","solute carrier family 25 member 40 isoform a","337",""
< "Q8BHN1-1","NP_849266.1","gamma-taxilin isoform 1","524",""
< "Q80X44-1","NP_700447.2","zinc finger and BTB domain-containing protein 24 isoform 1","710","This gene encodes a protein containing eight C2H2-type zinc fingers and a BTB domain. Expression of this gene is induced by bone morphogenetic protein-2 signaling. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies syndrome-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. "
< "Q8K2T1-1","NP_080669.1","nmrA-like family domain-containing protein 1 isoform 1","309",""
---
> "P10518-1","NP_001263375.1","delta-aminolevulinic acid dehydratase","330",""
> "Q5F2L2-1","NP_001012535.1","alpha-(1,3)-fucosyltransferase 10 isoform a","481",""
6406,6408c6370
< "Q91VM3-1","NP_758960.1","WD repeat domain phosphoinositide-interacting protein 4 isoform a","360",""
< "Q8CDV6-1","NP_899130.1","coiled-coil domain-containing protein 63 isoform 2","582",""
< "Q8C033-1","NP_766339.2","rho guanine nucleotide exchange factor 10 isoform a","1345",""
---
> "Q6P1H1-1","NP_001268993.1","cytochrome b ascorbate-dependent protein 3 isoform 1","242",""
6410,6413c6372,6377
< "Q9D1R9-1","NP_081000.1","60S ribosomal protein L34","117",""
< "Q80YF9-1","NP_839983.1","rho GTPase-activating protein 33 isoform a","1305",""
< "Q9CQ37-1","NP_080300.1","ubiquitin-conjugating enzyme E2 T","204",""
< "Q5SX79-1","NP_082193.2","protein Shroom1 isoform 1","823",""
---
> "Q8BP07-1","NP_001277971.1","transmembrane protein 220 isoform 2","167",""
> "Q8C1F5-1","NP_001277493.1","tetratricopeptide repeat protein 16 isoform c","767",""
> "Q8N9S3-1","NP_001277583.1","activator of 90 kDa heat shock protein ATPase homolog 2 isoform 2","283",""
> "Q8CDV6-1","NP_001276738.1","coiled-coil domain-containing protein 63 isoform 1","583",""
> "Q9CR89-1","NP_001273489.1","endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform 3","294",""
> "Q8CGA4-1","NP_001276669.1","maturin isoform a","131",""
6415,6418c6379,6380
< "Q6PD05-1","NP_083744.2","zinc finger protein 821 isoform a","413",""
< "Q8VD37-1","NP_659155.1","SH3-containing GRB2-like protein 3-interacting protein 1 isoform b","806",""
< "Q8C6Z1-1","NP_766567.1","mucin-15 isoform a precursor","331",""
< "Q3TJD7-1","NP_080407.3","PDZ and LIM domain protein 7 isoform c","188",""
---
> "Q9QY39-1","NP_001025039.1","PDZ domain-containing protein 4 isoform 1","772",""
> "Q9Z1L2-1","NP_001277993.1","synaptogyrin-4 isoform 2","136",""
6421,6425c6383,6385
< "Q8BZ94-1","NP_796060.1","zinc finger matrin-type protein 4 isoform 1","229",""
< "Q9Z2L7-1","NP_061246.1","cytokine receptor-like factor 3 isoform 1","442","This gene encodes a cytokine receptor-like factor that contains a fibronectin type 3 domain. The encoded protein may act as a negative regulator of the cell cycle. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. "
< "Q8K1H1-1","NP_666254.1","tudor domain-containing protein 7 isoform 2","1086",""
< "Q8BG34-1","NP_848786.1","UBX domain-containing protein 10","277",""
< "Q9D7W5-1","NP_776067.1","mediator of RNA polymerase II transcription subunit 8 isoform 2","234",""
---
> "Q7TT52-1","NP_001277725.1","protein phosphatase 1 regulatory subunit 14D isoform a","175",""
> "Q9D710-1","NP_001277680.1","thioredoxin-related transmembrane protein 2 isoform b","257",""
> "Q9D6N5-1","NP_001278009.1","dr1-associated corepressor isoform 1","212",""
6427a6388,6391
> "Q3TQB2-1","NP_001278377.1","FAD-dependent oxidoreductase domain-containing protein 1 isoform 2","487",""
> "Q3TV70-1","NP_001020757.1","nuclear receptor 2C2-associated protein isoform 1","140",""
> "Q9ERF3-1","NP_001020546.1","WD repeat-containing protein 61 isoform a","305",""
> "Q8BQC8-1","NP_001038947.1","RB-associated KRAB zinc finger protein","711",""
6429,6432c6393,6397
< "Q69Z89-1","NP_848817.2","ras-associating and dilute domain-containing protein isoform 2","1070",""
< "Q32M26-1","NP_849237.2","uncharacterized protein C11orf87 homolog precursor","199",""
< "Q3TQB2-1","NP_758495.1","FAD-dependent oxidoreductase domain-containing protein 1 isoform 1","493",""
< "Q9CQB7-1","NP_083886.1","LYR motif-containing protein 1","122",""
---
> "A6H6A4-1","NP_001277439.1","leucine-rich repeat and IQ domain-containing protein 4 isoform 2","581",""
> "Q8VC26-1","NP_001278085.1","TLC domain-containing protein 2 isoform 2","188",""
> "Q9D8N6-1","NP_001277498.1","protein lin-37 homolog isoform 2","234",""
> "Q8K2Q5-1","NP_001177251.1","coiled-coil-helix-coiled-coil-helix domain-containing protein 7","85",""
> "Q6NZP1-1","NP_001272874.1","DNA annealing helicase and endonuclease ZRANB3 isoform 2","1073",""
6434,6447c6399,6409
< "Q8C1M2-1","NP_780351.1","zinc finger protein 428 isoform a","189",""
< "Q8CGA4-1","NP_001276670.1","maturin isoform b","148",""
< "Q9DBZ5-1","NP_082935.1","eukaryotic translation initiation factor 3 subunit K isoform 1","218",""
< "Q8VD53-1","NP_647467.1","alkaline ceramidase 2 isoform 1","275",""
< "Q8BI99-1","NP_775563.1","zinc finger protein 879 isoform 1","563",""
< "Q4FZC9-1","NP_766088.2","nesprin-3 isoform beta","888",""
< "Q9D0I8-1","NP_076025.1","mRNA turnover protein 4 homolog isoform 2","238",""
< "Q3ULM6-1","NP_001273754.1","SUMO-specific isopeptidase USPL1 isoform B","890",""
< "Q8N9S3-1","NP_765979.3","activator of 90 kDa heat shock protein ATPase homolog 2 isoform 1","331",""
< "Q9D2L6-1","NP_084343.1","adhesion G protein-coupled receptor F4 precursor","698",""
< "Q91VV4-1","NP_001265870.1","DENN domain-containing protein 2D isoform 3","289",""
< "O08641-1","NP_038737.1","SH3 domain-containing YSC84-like protein 1 isoform 1","340",""
< "Q91WG3-1","NP_663495.3","mitochondrial mRNA pseudouridine synthase Trub2 isoform a","331",""
< "Q9CQJ2-1","NP_083682.1","PIH1 domain-containing protein 1","290",""
---
> "Q8BP97-1","NP_001277420.1","rhomboid domain-containing protein 3 isoform b","375",""
> "Q99KC7-1","NP_001029044.1","small cell adhesion glycoprotein isoform 1","97",""
> "Q8BHW5-1","NP_001276656.1","transmembrane protein 255A isoform 2","331",""
> "Q8BZ89-1","NP_001104577.1","zinc finger protein 322","410",""
> "Q8CFI5-1","NP_001272713.1","probable proline--tRNA ligase, mitochondrial isoform 1","475",""
> "Q8R3B7-1","NP_001276535.1","bromodomain-containing protein 8 isoform 2","878",""
> "Q3U2S4-1","NP_001277466.1","OTU domain-containing protein 5 isoform 3","523",""
> "Q61142-1","NP_001269957.1","spindlin-1 isoform 2","262",""
> "Q3TYU2-1","NP_001271304.1","probable cation-transporting ATPase 13A5 isoform 2","1171",""
> "Q8BGF9-1","NP_001139348.1","solute carrier family 25 member 44 isoform b","314",""
> "Q80SY6-1","NP_001277740.1","adenosine deaminase-like protein isoform b","293",""
6449,6452c6411
< "Q8JZK9-1","NP_666054.2","hydroxymethylglutaryl-CoA synthase, cytoplasmic","520",""
< "Q9D3S9-1","NP_082025.1","probable serine carboxypeptidase CPVL isoform 1 precursor","478","This gene encodes a member of the serine carboxypeptidase family of proteases that cleave amino acids from the C-terminus of a protein substrate. The human ortholog of this gene, where it was first characterized, was found to be upregulated during the maturation of monocytes to macrophages. The encoded protein may be involved in antigen processing, digestion of phagocytosed proteins in the lysosome and lamellipodium formation. Disruption of this gene in mice was found to cause embryonic lethality. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]. "
< "Q6NZP1-1","NP_081954.1","DNA annealing helicase and endonuclease ZRANB3 isoform 1","1069",""
< "Q640L3-1","NP_082457.3","cell cycle progression protein 1 isoform 2","638",""
---
> "Q9JMF7-1","NP_001277437.1","dolichyldiphosphatase 1 isoform b","140",""
6454c6413
< "Q3TY60-1","NP_083804.3","protein FAM131B isoform a","360",""
---
> "Q497K7-1","NP_001264909.1","transmembrane protein 247 isoform 2","212",""
6456c6415
< "Q3U1J1-1","NP_076013.1","TCF3 fusion partner homolog isoform 2","249",""
---
> "Q640L3-1","NP_001107800.1","cell cycle progression protein 1 isoform 1","753",""
6457a6417
> "Q6NZQ6-1","NP_001276620.1","zinc finger protein 740 isoform 2","168",""
6458a6419
> "Q80W22-1","NP_001029101.1","threonine synthase-like 2","483",""
6460,6462c6421,6423
< "Q9QY39-1","NP_001277469.1","PDZ domain-containing protein 4 isoform 2","657",""
< "A2AR95-1","NP_849217.2","low-density lipoprotein receptor class A domain-containing protein 3 isoform a precursor","345",""
< "A2A7S8-1","NP_001272796.1","uncharacterized protein KIAA1522 isoform d","900",""
---
> "Q9CQJ2-1","NP_001265136.1","PIH1 domain-containing protein 1","290",""
> "Q5U901-1","NP_001276426.1","carboxypeptidase A6 isoform 2","262","This gene encodes a protein that belongs to the metallocarboxypeptidase family of proteins that catalyze the release of a C-terminal amino acid from the target protein. The encoded preproprotein undergoes proteolytic cleavage to yield the mature form which is thought to play a role in cell migration. In humans, this protein regulates neuropeptides in the brain and mutations in this gene are associated with a recessive familial form of febrile seizures and with temporal lobe epilepsy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]. "
> "Q8VC34-1","NP_001156933.1","putative RNA polymerase II subunit B1 CTD phosphatase Rpap2 isoform B","568",""
6463a6425,6428
> "Q9CWP6-1","NP_001277452.1","motile sperm domain-containing protein 2 isoform 2","486",""
> "Q8C3M9-1","NP_001272810.1","uncharacterized protein C2orf80 homolog isoform 2","225",""
> "A2A8U2-1","NP_001271199.1","transmembrane protein 201 isoform c","664",""
> "Q7TQ62-1","NP_001272885.1","podocan precursor","611",""
6465,6467c6430,6433
< "Q3UV70-1","NP_001277320.1","[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform b","563",""
< "Q7TQ62-1","NP_766462.2","podocan precursor","611",""
< "Q8VE91-4","NP_079735.2","reticulophagy regulator 1 isoform 2","356",""
---
> "A2AIG8-1","NP_001277711.1","1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform a","502",""
> "Q8CBR1-1","NP_001272717.1","immunoglobulin-like domain-containing receptor 1 isoform 1 precursor","537",""
> "Q6PD05-1","NP_001161418.1","zinc finger protein 821 isoform a","413",""
> "Q8BHL7-1","NP_001033797.1","CDC42 small effector protein 1","80",""
6469,6471d6434
< "A2AIG8-1","NP_899043.1","1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform b","479",""
< "O35448-1","NP_062314.1","lysosomal thioesterase PPT2 precursor","302",""
< "Q9CQE0-1","NP_997506.1","E3 ubiquitin-protein ligase RNF138 isoform 1","245",""
6472a6436,6441
> "Q8K2A7-1","NP_001280720.1","integrator complex subunit 10 isoform 1","736",""
> "Q8BJQ2-1","NP_001288343.1","ubiquitin carboxyl-terminal hydrolase 1 isoform 1","784","This gene encodes a member of the ubiquitin-specific peptidase family. The encoded protein acts as a catalytic subunit in a heterodimeric deubiquitinating enzyme complex that deubiquitinates Fanconi anemia, complementation group D2, and plays a role in homologous recombination-mediated DNA repair. Disruption of this gene is associated with a Fanconi anemia-like phenotype and genomic instability. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 3, 12, and 15. [provided by RefSeq, Aug 2014]. "
> "Q8C878-1","NP_001104576.1","NEDD8-activating enzyme E1 catalytic subunit isoform 2","448","The protein encoded by this gene is the catalytic subunit of the enzyme that activates NEDD8, a ubiquitin-like molecule that binds to its target proteins through an enzymatic reaction analagous to ubiquitylation. Embryonic mice deficient for this protein die prior to implantation and display apoptosis of the inner cell mass. Trophoblastic cells cannot enter S phase, demonstrating that this gene is required for cell cycle progression during embryogenesis. Two pseudogenes have been found for this gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]. "
> "Q9DAX2-1","NP_001289318.1","phospholipid phosphatase 2 isoform 2","220","The protein encoded by this gene is a lipid phosphate phosphohydrolase. It is an integral membrane protein that catalyzes the conversion of phosphatidic acid to diacylglycerol and inorganic phosphate. The transcript is expressed at high levels in lung, liver, and kidney and at low levels in brain and heart. Null mutant mice are viable and fertile and display no overt phenotypic defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
> "Q8CG48-1","NP_001288341.1","structural maintenance of chromosomes protein 2","1191","The protein encoded by this gene is a component of both condensin I and condensin II complexes, and forms a heterodimer with structural maintenance of chromosome 4 (Smc4). This heterodimer is the catalytic subunit for both condensin complexes, and is involved in several processes, including chromosome condensation during mitosis and meiosis, cohesin removal during mitosis and meiosis, and single-strand break (SSB) repair. Reduced expression of this gene results in chromosome segregation defects during mitosis and meiosis, with a more severe defect observed in embryonic stem cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. "
> "Q810A1-1","NP_001289303.1","zinc finger protein 18 isoform 1","556",""
6473a6443
> "Q562E2-1","NP_001288102.1","BTB/POZ domain-containing protein KCTD19 isoform 2","927",""
6474a6445
> "Q9CQU5-1","NP_001280612.1","ZW10 interactor","252",""
6476,6477c6447,6449
< "A2A8U2-1","NP_808340.2","transmembrane protein 201 isoform b","392",""
< "Q9JMF7-1","NP_065062.1","dolichyldiphosphatase 1 isoform a","238",""
---
> "Q5SXI5-1","NP_001124001.1","zinc finger protein 496 isoform 2","565",""
> "Q3U3F9-1","NP_001127857.1","probable G-protein coupled receptor 160","336",""
> "Q5SWZ9-1","NP_001277212.1","mitochondrial cardiolipin hydrolase isoform a","221",""
6481,6484c6453,6457
< "Q8VDS8-1","NP_081235.2","syntaxin-18 isoform 1","334",""
< "Q8BXL9-1","NP_848902.4","intermediate filament family orphan 1 isoform b","559",""
< "Q8C255-1","NP_795887.2","dipeptidase 2 isoform 3","578",""
< "Q3TFK5-1","NP_079939.3","G patch domain-containing protein 4","415",""
---
> "Q6NXN1-1","NP_001020779.1","SUZ domain-containing protein 1 isoform 1","152",""
> "Q3TFK5-1","NP_001104279.1","G patch domain-containing protein 4","415",""
> "Q9D516-1","NP_001281210.1","coiled-coil domain-containing protein 130 isoform 2","198",""
> "Q9CQB7-1","NP_001272888.1","LYR motif-containing protein 1","122",""
> "Q8K5B2-1","NP_647456.1","multiple coagulation factor deficiency protein 2 homolog precursor","145",""
6486,6487c6459
< "Q9EPR2-1","NP_904359.1","group XIIA secretory phospholipase A2 isoform 2","153",""
< "Q62082-1","NP_001289950.1","myosin regulatory light chain 10 isoform 2","131",""
---
> "Q8R5F3-1","NP_001276419.1","ADP-ribose glycohydrolase OARD1","152",""
6488a6461
> "Q921R8-1","NP_001032570.1","solute carrier family 41 member 3 isoform 2","462",""
6490,6491d6462
< "Q80W22-1","NP_848500.3","threonine synthase-like 2","483",""
< "P51954-1","NP_780298.2","serine/threonine-protein kinase Nek1 isoform 3","1203",""
6493,6494d6463
< "Q91XE4-1","NP_001289411.1","N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform 2","189","This gene encodes a member of the aminoacylase family of enzymes. This enzyme specifically deacetylates N-acetyl aromatic amino acids and mercapturic acids. Action of this enzyme on metabolites of the environmental contaminant trichloroethylene leads to the generation of toxic products that may lead to kidney failure. This protein has been found to bind to the hepatitis C virus core protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
< "A1Y9I9-1","NP_001269017.1","transmembrane O-methyltransferase homolog","258",""
6496,6498d6464
< "Q9DAX2-1","NP_056632.2","phospholipid phosphatase 2 isoform 1","276","The protein encoded by this gene is a lipid phosphate phosphohydrolase. It is an integral membrane protein that catalyzes the conversion of phosphatidic acid to diacylglycerol and inorganic phosphate. The transcript is expressed at high levels in lung, liver, and kidney and at low levels in brain and heart. Null mutant mice are viable and fertile and display no overt phenotypic defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
< "Q80ZN9-1","NP_899665.1","cytochrome c oxidase subunit 6B2 isoform 1","88",""
< "Q8R3B7-1","NP_084423.2","bromodomain-containing protein 8 isoform 1","951",""
6500d6465
< "Q8BKK4-1","NP_766008.2","protein phosphatase 1 regulatory subunit 1C isoform a","108",""
6503,6509c6468,6473
< "Q8K2A7-1","NP_081866.1","integrator complex subunit 10 isoform 3","710",""
< "Q925E8-1","NP_598436.1","serine palmitoyltransferase small subunit B isoform a","76",""
< "Q3UQV5-1","NP_001096140.1","kelch repeat and BTB domain-containing protein 8 isoform b","522",""
< "Q78T54-1","NP_001277710.1","vacuolar ATPase assembly integral membrane protein Vma21 isoform 3","120",""
< "Q3UZD7-1","NP_997141.2","protein FAM71F1 isoform 3","341",""
< "Q9D516-1","NP_080626.1","coiled-coil domain-containing protein 130 isoform 1","385",""
< "Q80ZE4-1","NP_082271.1","membrane progestin receptor alpha","345",""
---
> "Q9DB26-1","NP_001239497.1","phytanoyl-CoA dioxygenase domain-containing protein 1 isoform 2","288",""
> "Q9CQ60-1","NP_001281198.1","6-phosphogluconolactonase isoform 2","174",""
> "Q66X03-1","NP_001041684.1","NACHT, LRR and PYD domains-containing protein 9A isoform 1","1004",""
> "Q9D3S9-1","NP_001276642.1","probable serine carboxypeptidase CPVL isoform 1 precursor","478","This gene encodes a member of the serine carboxypeptidase family of proteases that cleave amino acids from the C-terminus of a protein substrate. The human ortholog of this gene, where it was first characterized, was found to be upregulated during the maturation of monocytes to macrophages. The encoded protein may be involved in antigen processing, digestion of phagocytosed proteins in the lysosome and lamellipodium formation. Disruption of this gene in mice was found to cause embryonic lethality. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]. "
> "Q91WG3-1","NP_001277425.1","mitochondrial mRNA pseudouridine synthase Trub2 isoform c","194",""
> "Q8BP86-1","NP_001277348.1","snRNA-activating protein complex subunit 4 isoform b","1235",""
6511,6513c6475
< "Q8BJQ2-1","NP_666256.2","ubiquitin carboxyl-terminal hydrolase 1 isoform 1","784","This gene encodes a member of the ubiquitin-specific peptidase family. The encoded protein acts as a catalytic subunit in a heterodimeric deubiquitinating enzyme complex that deubiquitinates Fanconi anemia, complementation group D2, and plays a role in homologous recombination-mediated DNA repair. Disruption of this gene is associated with a Fanconi anemia-like phenotype and genomic instability. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 3, 12, and 15. [provided by RefSeq, Aug 2014]. "
< "Q9D710-1","NP_080144.1","thioredoxin-related transmembrane protein 2 isoform a precursor","295",""
< "Q9D0Z3-1","NP_083865.1","transmembrane protein 53 isoform c","261",""
---
> "Q9D0I8-1","NP_001277739.1","mRNA turnover protein 4 homolog isoform 1","239",""
6515c6477
< "Q5SXI5-1","NP_766529.3","zinc finger protein 496 isoform 1","585",""
---
> "O08641-1","NP_001276409.1","SH3 domain-containing YSC84-like protein 1 isoform 2","302",""
6517,6520c6479,6485
< "Q8R242-1","NP_083112.1","di-N-acetylchitobiase isoform 2 precursor","312",""
< "P10518-1","NP_032551.3","delta-aminolevulinic acid dehydratase","330",""
< "Q8C4W3-1","NP_778189.1","neuritin-like protein isoform 1 precursor","162",""
< "Q6NXN1-1","NP_001264124.1","SUZ domain-containing protein 1 isoform 3","151",""
---
> "Q3UW26-1","NP_001028590.1","binder of sperm protein homolog 1 isoform 1 precursor","133","This gene encodes a member of the binder of sperm family. The encoded protein may be involved in sperm capacitation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. "
> "P02664-1","NP_001288263.1","alpha-S2-casein-like B isoform 2 precursor","138","This gene is a member of the alpha-s2-like casein gene family, and this gene product is a calcium-sensitive casein. Members of this gene family are organized as a gene cluster that is conserved in its order, but with greater conservation amongst orthologs than paralogs. The protein encoded by this gene interacts with other casein proteins to form a micelle structure, and is a major source of protein in milk. This structure is important for the transport of calcium, phosphate, and protein. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Aug 2014]. "
> "Q8VDG7-1","NP_001272803.1","platelet-activating factor acetylhydrolase 2, cytoplasmic isoform b","390",""
> "Q99L43-1","NP_001277968.1","phosphatidate cytidylyltransferase 2 isoform b","427",""
> "Q8BHN1-1","NP_001277705.1","gamma-taxilin isoform 2","475",""
> "Q8BXL9-1","NP_001034758.1","intermediate filament family orphan 1 isoform a","562",""
> "Q8BJI1-1","NP_001280618.1","sodium-dependent neutral amino acid transporter SLC6A17 isoform 1","727",""
6522c6487,6489
< "Q810L3-1","NP_766305.2","E3 ubiquitin-protein ligase CHFR isoform 2","663",""
---
> "Q5GH66-1","NP_001106821.1","XK-related protein 5 isoform a","676",""
> "Q8R184-1","NP_001276079.1","protein FAM110A","296",""
> "Q9ESC7-1","NP_001277976.1","protein yippee-like 1 isoform 1","193",""
6524,6528c6491,6499
< "Q99LW0-1","NP_598732.2","ankyrin repeat domain-containing protein 10 isoform 1","415",""
< "Q9D6G5-1","NP_082687.1","transmembrane protein 138 isoform 1","162",""
< "Q8BGS7-1","NP_598630.2","choline/ethanolaminephosphotransferase 1 isoform 1","416",""
< "Q8CG48-1","NP_032043.3","structural maintenance of chromosomes protein 2","1191","The protein encoded by this gene is a component of both condensin I and condensin II complexes, and forms a heterodimer with structural maintenance of chromosome 4 (Smc4). This heterodimer is the catalytic subunit for both condensin complexes, and is involved in several processes, including chromosome condensation during mitosis and meiosis, cohesin removal during mitosis and meiosis, and single-strand break (SSB) repair. Reduced expression of this gene results in chromosome segregation defects during mitosis and meiosis, with a more severe defect observed in embryonic stem cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. "
< "Q8CBR1-1","NP_598870.1","immunoglobulin-like domain-containing receptor 1 isoform 2 precursor","516",""
---
> "Q6SJ95-1","NP_001276618.1","TATA box-binding protein-like protein 2 isoform 2","349",""
> "Q8BGP6-1","NP_001276524.1","solute carrier family 25 member 40 isoform a","337",""
> "Q9DD02-1","NP_001278215.1","protein Hikeshi isoform b","177",""
> "Q8VCA6-1","NP_001280726.1","transmembrane protein 161A isoform 2 precursor","328",""
> "A2ALU4-1","NP_001277613.1","protein Shroom2 isoform 2","1481",""
> "Q80ZE4-1","NP_001272774.1","membrane progestin receptor alpha","345",""
> "Q9D7I0-1","NP_001271261.1","protein shisa-5 isoform 3 precursor","236",""
> "P58749-1","NP_001278211.1","transmembrane 6 superfamily member 1 isoform 2","279",""
> "Q810S1-1","NP_001280573.1","calcium uniporter regulatory subunit MCUb, mitochondrial isoform 2","252",""
6530,6531c6501
< "Q6PE13-1","NP_766075.2","proline-rich transmembrane protein 3 isoform b precursor","971",""
< "A2ALU4-1","NP_766029.2","protein Shroom2 isoform 1","1487",""
---
> "Q5SX79-1","NP_001277718.1","protein Shroom1 isoform 2","760",""
6533d6502
< "Q80TF4-1","NP_080443.1","kelch-like protein 13 isoform 1","638",""
6534a6504,6505
> "Q61908-1","NP_001281206.1","cx9C motif-containing protein 4","68",""
> "Q8K2T1-1","NP_001277690.1","nmrA-like family domain-containing protein 1 isoform 2","299",""
6536,6547c6507,6514
< "Q8BXX9-1","NP_796177.2","coiled-coil domain-containing protein 169 isoform a","214",""
< "Q99L43-1","NP_619592.1","phosphatidate cytidylyltransferase 2 isoform a","444",""
< "Q80SY6-1","NP_083751.1","adenosine deaminase-like protein isoform a","360",""
< "Q9ERF3-1","NP_075680.1","WD repeat-containing protein 61 isoform a","305",""
< "Q810A1-1","NP_080383.2","zinc finger protein 18 isoform 1","556",""
< "Q8BG15-1","NP_997615.1","CTD small phosphatase-like protein 2 isoform a","465",""
< "Q8BSN5-1","NP_084340.2","PHD finger protein 23 isoform a","401",""
< "Q6NZK8-1","NP_997115.1","protein tyrosine phosphatase domain-containing protein 1 isoform 2","747","The protein encoded by this gene is a centrosomal mitotic phosphatase. This protein has been implicated in centrosomal duplication and cytokinesis. In addition, knockdown of expression levels in non-cycling cells results in extra long cilia, suggesting that this protein may function in regulating cilia length independent of a function in cell cycle control. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]. "
< "Q562E2-1","NP_808459.1","BTB/POZ domain-containing protein KCTD19 isoform 1","950",""
< "Q8R184-1","NP_666239.1","protein FAM110A","296",""
< "Q8C1F5-1","NP_001277496.1","tetratricopeptide repeat protein 16 isoform c","767",""
< "Q8CDP0-1","NP_848745.2","cytosolic carboxypeptidase 3 isoform 2","1001",""
---
> "O35448-1","NP_001289322.1","lysosomal thioesterase PPT2 precursor","302",""
> "Q05A80-1","NP_001288280.1","caprin-2 isoform 2","811","This gene encodes a member of the caprin family. The encoded protein may function as an RNA-binding protein that induces the formation of RNA granules and plays an important role in brain function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. "
> "Q8BGS7-1","NP_001280623.1","choline/ethanolaminephosphotransferase 1 isoform 2","416",""
> "Q3UQ22-1","NP_001028528.2","netrin-5 isoform a precursor","452",""
> "Q8JZK9-1","NP_001278368.1","hydroxymethylglutaryl-CoA synthase, cytoplasmic","520",""
> "Q8BGD0-1","NP_001271312.1","uncharacterized protein C3orf14 homolog isoform 2","127",""
> "Q8BN82-1","NP_001263381.1","sialin isoform b","469",""
> "Q9JKD3-1","NP_001288563.1","secretory carrier-associated membrane protein 5 isoform 1","235","This gene encodes a member of the Scamp (secretory carrier membrane protein) family. The encoded protein may be involved in neuronal vesicle trafficking. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. "
6549c6516
< "Q6R3M4-1","NP_001276445.1","DNA polymerase iota isoform 4","651",""
---
> "Q8BSI6-1","NP_001139484.2","R3H and coiled-coil domain-containing protein 1 isoform b","488",""
6551,6562c6518,6526
< "P56983-1","NP_083674.2","transmembrane protein 14A isoform 2","99",""
< "Q5GH66-1","NP_795925.1","XK-related protein 5 isoform b","510",""
< "Q7TNJ0-1","NP_083698.1","dendritic cell-specific transmembrane protein isoform 1","470",""
< "Q3UTA9-1","NP_001273109.1","eukaryotic translation initiation factor 4E type 1B isoform 5","188",""
< "Q8K5B2-1","NP_789778.1","multiple coagulation factor deficiency protein 2 homolog precursor","145",""
< "Q8K2Q5-1","NP_852056.1","coiled-coil-helix-coiled-coil-helix domain-containing protein 7","85",""
< "Q9D3X9-1","NP_082032.1","microfibrillar-associated protein 3-like isoform a precursor","409",""
< "O54834-1","NP_848869.1","rho GTPase-activating protein 6 isoform b","805",""
< "Q05A80-1","NP_853519.2","caprin-2 isoform 1","1031","This gene encodes a member of the caprin family. The encoded protein may function as an RNA-binding protein that induces the formation of RNA granules and plays an important role in brain function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. "
< "Q3UW26-1","NP_001288611.1","binder of sperm protein homolog 1 isoform 2 precursor","123","This gene encodes a member of the binder of sperm family. The encoded protein may be involved in sperm capacitation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. "
< "Q61142-1","NP_666155.1","spindlin-1 isoform 2","262",""
< "Q8BSI6-1","NP_001288581.1","R3H and coiled-coil domain-containing protein 1 isoform b","488",""
---
> "Q9R1R2-1","NP_001272799.1","tripartite motif-containing protein 3 isoform a","744",""
> "Q5U5Q9-1","NP_001280589.1","BRCA1-A complex subunit RAP80 isoform 2","446",""
> "Q9CQE0-1","NP_001289934.1","E3 ubiquitin-protein ligase RNF138 isoform 3","131",""
> "Q3URJ8-1","NP_001277339.1","sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 isoform 1 precursor","181",""
> "Q505G8-1","NP_001281208.1","zinc finger protein 827 isoform 2","1074",""
> "Q32M26-1","NP_001273570.1","uncharacterized protein C11orf87 homolog precursor","199",""
> "Q9CQ89-1","NP_080583.3","protein CutA isoform 1 precursor","177",""
> "Q8CFQ3-1","NP_001277717.1","RNA helicase aquarius isoform b","1400",""
> "Q9CWV1-1","NP_001277983.1","DNA helicase MCM8 isoform a","833",""
6564,6565d6527
< "Q9JIB0-1","NP_067304.1","ran guanine nucleotide release factor isoform 2","185",""
< "Q45VN2-1","NP_899091.2","alpha-defensin 20 precursor","95",""
6568,6570c6530,6534
< "Q9CQU5-1","NP_079911.1","ZW10 interactor","252",""
< "Q14AW5-1","NP_081878.1","putative methyltransferase NSUN7 isoform 3","700","This gene encodes a member of the NOL1/NOP2/sun domain RNA methyltransferase family. Mice with a mutation in this gene exhibit male sterility due to impaired sperm motility. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]. "
< "Q8C4P0-1","NP_694798.1","uncharacterized protein KIAA1958 homolog isoform 1","737",""
---
> "Q9CR48-1","NP_001273915.1","DNA damage-regulated autophagy modulator protein 2 isoform 2","267",""
> "Q9D6G5-1","NP_001289147.1","transmembrane protein 138 isoform 2","101",""
> "Q8R242-1","NP_001280601.1","di-N-acetylchitobiase isoform 1 precursor","366",""
> "Q9ERQ8-1","NP_001288093.1","carbonic anhydrase 7 isoform b","208",""
> "P56983-1","NP_001277608.1","transmembrane protein 14A isoform 1","145",""
6571a6536
> "Q3TY60-1","NP_001106798.1","protein FAM131B isoform b","348",""
6573,6577c6538,6543
< "P02664-1","NP_034103.2","alpha-S2-casein-like B isoform 1 precursor","143","This gene is a member of the alpha-s2-like casein gene family, and this gene product is a calcium-sensitive casein. Members of this gene family are organized as a gene cluster that is conserved in its order, but with greater conservation amongst orthologs than paralogs. The protein encoded by this gene interacts with other casein proteins to form a micelle structure, and is a major source of protein in milk. This structure is important for the transport of calcium, phosphate, and protein. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Aug 2014]. "
< "Q99N11-1","NP_598829.1","dual specificity protein phosphatase 22 isoform b","184",""
< "Q5U901-1","NP_808502.2","carboxypeptidase A6 isoform 1 preproprotein","438","This gene encodes a protein that belongs to the metallocarboxypeptidase family of proteins that catalyze the release of a C-terminal amino acid from the target protein. The encoded preproprotein undergoes proteolytic cleavage to yield the mature form which is thought to play a role in cell migration. In humans, this protein regulates neuropeptides in the brain and mutations in this gene are associated with a recessive familial form of febrile seizures and with temporal lobe epilepsy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]. "
< "Q66X03-1","NP_001041685.1","NACHT, LRR and PYD domains-containing protein 9A isoform 2","949",""
< "Q6PAQ9-1","NP_001289957.1","transmembrane gamma-carboxyglutamic acid protein 3 precursor","231","This gene encodes proline-rich gamma-carboxyglutamic acid protein 3, a member of vitamin K-dependent membrane proteins containing gamma-carboxyglutamic acid residues. The encoded precursor protein contains an N-terminal propeptide that is required for the carboxylation of glutamate residues in the mature protein. Alternate splicing of this gene results in multiple transcript variants that encode the same protein. [provided by RefSeq, Dec 2014]. "
---
> "Q8C255-1","NP_001288133.1","dipeptidase 2 isoform 1 precursor","478",""
> "Q78T54-1","NP_001074825.1","vacuolar ATPase assembly integral membrane protein Vma21 isoform 2","101",""
> "Q3UTA9-1","NP_001028441.1","eukaryotic translation initiation factor 4E type 1B isoform 1","244",""
> "Q8VDS8-1","NP_001276464.1","syntaxin-18 isoform 2","308",""
> "Q8C460-1","NP_001272828.1","ERI1 exoribonuclease 3 isoform b","296",""
> "Q91VM3-1","NP_001277721.1","WD repeat domain phosphoinositide-interacting protein 4 isoform a","360",""
6579,6581c6545,6548
< "Q8BHL7-1","NP_765983.1","CDC42 small effector protein 1","80",""
< "Q8VC26-1","NP_081525.1","TLC domain-containing protein 2 isoform 1","310",""
< "Q8BHW5-1","NP_766518.3","transmembrane protein 255A isoform 1","351",""
---
> "Q5SS91-1","NP_001277448.1","SUN domain-containing protein 3 isoform a","320",""
> "Q8C4W3-1","NP_001288103.1","neuritin-like protein isoform 2 precursor","161",""
> "Q8C6Z1-1","NP_001277715.1","mucin-15 isoform b precursor","284",""
> "Q6NY15-1","NP_001277649.1","testis-specific gene 10 protein isoform 2","620",""
6583c6550,6551
< "Q8C878-1","NP_035796.2","NEDD8-activating enzyme E1 catalytic subunit isoform 1","462","The protein encoded by this gene is the catalytic subunit of the enzyme that activates NEDD8, a ubiquitin-like molecule that binds to its target proteins through an enzymatic reaction analagous to ubiquitylation. Embryonic mice deficient for this protein die prior to implantation and display apoptosis of the inner cell mass. Trophoblastic cells cannot enter S phase, demonstrating that this gene is required for cell cycle progression during embryogenesis. Two pseudogenes have been found for this gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]. "
---
> "Q8VD53-1","NP_001277470.1","alkaline ceramidase 2 isoform 2","229",""
> "Q6PAQ9-1","NP_001074604.1","transmembrane gamma-carboxyglutamic acid protein 3 precursor","231","This gene encodes proline-rich gamma-carboxyglutamic acid protein 3, a member of vitamin K-dependent membrane proteins containing gamma-carboxyglutamic acid residues. The encoded precursor protein contains an N-terminal propeptide that is required for the carboxylation of glutamate residues in the mature protein. Alternate splicing of this gene results in multiple transcript variants that encode the same protein. [provided by RefSeq, Dec 2014]. "
6585,6586c6553,6554
< "Q8BW96-1","NP_796317.2","calcium/calmodulin-dependent protein kinase type 1D isoform a","385",""
< "Q8BGD0-1","NP_835277.1","uncharacterized protein C3orf14 homolog isoform 2","127",""
---
> "Q9CZ44-1","NP_001278003.1","NSFL1 cofactor p47 isoform b","370",""
> "Q7TQ07-1","NP_001276732.1","DNA polymerase nu isoform 2","848",""
6587a6556,6557
> "Q62082-1","NP_001078856.1","myosin regulatory light chain 10 isoform 2","131",""
> "Q3UZD7-1","NP_001276592.1","protein FAM71F1 isoform 1","344",""
6588a6559
> "P51954-1","NP_001280566.1","serine/threonine-protein kinase Nek1 isoform 1","1275",""
6590,6591c6561,6563
< "Q8BQR4-1","NP_598475.2","KAT8 regulatory NSL complex subunit 2 isoform a","486",""
< "Q6PGD0-1","NP_997635.1","all-trans retinoic acid-induced differentiation factor isoform 2","162",""
---
> "Q91XE4-1","NP_001289408.1","N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform 1","318","This gene encodes a member of the aminoacylase family of enzymes. This enzyme specifically deacetylates N-acetyl aromatic amino acids and mercapturic acids. Action of this enzyme on metabolites of the environmental contaminant trichloroethylene leads to the generation of toxic products that may lead to kidney failure. This protein has been found to bind to the hepatitis C virus core protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
> "Q80ZN9-1","NP_001276777.1","cytochrome c oxidase subunit 6B2 isoform 1","88",""
> "Q6PGA0-1","NP_001277207.1","REST corepressor 3 isoform b","434",""
6593,6602c6565,6571
< "Q3U2S4-1","NP_613070.2","OTU domain-containing protein 5 isoform 2","566",""
< "Q3TV70-1","NP_001020758.1","nuclear receptor 2C2-associated protein isoform 2","116",""
< "Q9CQG1-1","NP_080803.1","putative glutathione-specific gamma-glutamylcyclotransferase 2 isoform 1","178",""
< "Q9JKD3-1","NP_064666.1","secretory carrier-associated membrane protein 5 isoform 1","235","This gene encodes a member of the Scamp (secretory carrier membrane protein) family. The encoded protein may be involved in neuronal vesicle trafficking. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. "
< "Q8VCA6-1","NP_663572.1","transmembrane protein 161A isoform 1 precursor","480",""
< "P58749-1","NP_663350.2","transmembrane 6 superfamily member 1 isoform 1","370",""
< "A8VU90-1","NP_766344.2","ankyrin repeat and LEM domain-containing protein 1 isoform 1","534",""
< "E9Q6J5-1","NP_001297530.1","biorientation of chromosomes in cell division protein 1-like 1 isoform 2","2985",""
< "Q91VH1-1","NP_082596.2","adiponectin receptor protein 1","375","This gene encodes a receptor for the fat-derived hormone adiponectin. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. Homozygous knockout mice for this gene exhibit elevated plasma glucose and insulin levels as well as impaired glucose tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
< "Q9ESM6-1","NP_076097.1","glycerophosphoinositol inositolphosphodiesterase GDPD2","539","This gene encodes a member of the glycerophosphodiester phosphodiesterase enzyme family. The encoded protein hydrolyzes glycerophosphoinositol to produce inositol 1-phosphate and glycerol. Overexpression of this gene is associated with activity-dependent actin cytoskeleton disorganization. The encoded protein may negatively regulate growth rate and induce differentiation of osteoblasts. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
---
> "Q8BI99-1","NP_001277708.1","zinc finger protein 879 isoform 2","490",""
> "O54834-1","NP_001274459.1","rho GTPase-activating protein 6 isoform c","795",""
> "Q9CQG1-1","NP_001277596.1","putative glutathione-specific gamma-glutamylcyclotransferase 2 isoform 2","166",""
> "Q8VD37-1","NP_001272788.1","SH3-containing GRB2-like protein 3-interacting protein 1 isoform c","659",""
> "Q14AW5-1","NP_001289762.1","putative methyltransferase NSUN7 isoform 1","705","This gene encodes a member of the NOL1/NOP2/sun domain RNA methyltransferase family. Mice with a mutation in this gene exhibit male sterility due to impaired sperm motility. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]. "
> "Q640P7-1","NP_001074837.1","TBCC domain-containing protein 1","552",""
> "E9Q6J5-1","NP_001074891.1","biorientation of chromosomes in cell division protein 1-like 1 isoform 1","3032",""
6604,6606c6573,6575
< "Q9DA32-1","NP_083875.1","SUN domain-containing protein 5 isoform 2","348",""
< "Q8BRF7-1","NP_084101.1","sec1 family domain-containing protein 1 isoform 1","639",""
< "A2AG50-1","NP_001300682.1","MAP7 domain-containing protein 2 isoform 3","597",""
---
> "Q8BVN0-1","NP_001297577.1","coiled-coil domain-containing protein 122 isoform 2","214",""
> "Q91WU4-1","NP_001292352.1","transmembrane and coiled-coil domain-containing protein 4","631",""
> "Q8C7V8-1","NP_001313517.1","coiled-coil domain-containing protein 134 isoform 2","192",""
6609,6610c6578,6579
< "Q3V0Q6-1","NP_001277391.1","sperm-associated antigen 8 isoform 1","470",""
< "Q8BMD6-1","NP_766188.3","transmembrane protein 260 isoform 1","703",""
---
> "Q3UQA7-1","NP_001028338.1","selenoprotein H","116","This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]. "
> "Q924W5-1","NP_001311405.1","structural maintenance of chromosomes protein 6 isoform 2","899",""
6611a6581
> "Q3ULW6-1","NP_001298014.1","coiled-coil domain-containing protein 33 isoform 3","730",""
6613c6583
< "Q8BNL5-1","NP_082058.1","BTB/POZ domain-containing protein KCTD6","237",""
---
> "Q8BIS8-1","NP_001298041.1","coiled-coil domain-containing protein 126 isoform 2 precursor","103",""
6615d6584
< "Q9D2X0-1","NP_080517.1","ankyrin repeat domain-containing protein 39 isoform 1","183",""
6617c6586,6587
< "Q3TFQ1-1","NP_079973.1","SPRY domain-containing protein 7 isoform 1","196",""
---
> "Q3UA16-1","NP_001186052.1","kinetochore protein Spc25 isoform 1","226","This gene encodes a component of the kinetochore-associated NDC80 protein complex, which is required for the mitotic spindle checkpoint and for microtubule-kinetochore attachment. During meiosis in mouse, the protein localizes to the germinal vesicle and then is associated with the chromosomes following germinal vesicle breakdown. Knockdown of this gene in oocytes results in precocious polar body extrusion, chromosome misalignment and aberrant spindle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
> "Q6PAL8-1","NP_001298068.1","DENN domain-containing protein 5A isoform 2","1263",""
6620a6591,6592
> "O88495-1","NP_001295430.1","melatonin-related receptor isoform 2","243","This gene encodes a multipass membrane protein that is thought to act as a G protein-coupled receptor. Activity of this protein may be important in neurotransmitter and glucocorticoid signalling. Mutation of this gene causes a decreased ability to maintain a constant body temperature, resulting in torpor, as well as an increased metabolic rate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]. "
> "Q6P5F7-1","NP_001294969.1","protein tweety homolog 3 isoform 3","479",""
6622c6594
< "Q3UQA7-1","NP_001032356.1","selenoprotein H","116","This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]. "
---
> "Q99LH9-1","NP_001154810.1","SH3 domain-binding protein 5-like isoform 1","392",""
6624a6597
> "Q6PDX6-1","NP_001297658.1","E3 ubiquitin-protein ligase Rnf220 isoform 2","353",""
6626a6600,6601
> "Q3TY65-1","NP_001303623.1","islet cell autoantigen 1-like protein isoform a","431",""
> "A2AG50-1","NP_001074593.1","MAP7 domain-containing protein 2 isoform 1","781",""
6629,6630c6604,6606
< "Q6AW69-1","NP_080875.3","cingulin-like protein 1","1297","This gene encodes a protein localized to the tight junctions and adherens junctions in vertebrate epithelial cells. The encoded protein regulates the activity of Rho family GTPases during junction assembly and at confluence. At the adherens junctions, the encoded protein is part of a protein complex that links E-cadherin to the microtubule cytoskeleton. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]. "
< "Q8CI85-1","NP_848483.3","carbonic anhydrase 12 isoform 1 precursor","354","This gene encodes a membrane-bound member of the alpha carbonic anhydrase family of enzymes that catalyze the reversible hydration of carbon dioxide to bicarbonate. These proteins participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
---
> "Q8BZ36-1","NP_001297396.1","RAD50-interacting protein 1 isoform 2","734",""
> "Q8C9J3-1","NP_001291971.1","sperm flagellar protein 2 isoform 1","1798",""
> "Q6NS82-1","NP_001292160.1","reticulophagy regulator 2 isoform 2","504",""
6632d6607
< "Q99LH9-1","NP_077800.3","SH3 domain-binding protein 5-like isoform 1","392",""
6635,6636c6610,6614
< "Q9CQM6-1","NP_080008.1","ankyrin repeat domain-containing protein 61 isoform 1","421",""
< "Q91YN5-1","NP_598567.2","UDP-N-acetylhexosamine pyrophosphorylase isoform 2","521",""
---
> "Q8BJ52-1","NP_001292380.1","phospholipid phosphatase-related protein type 5 isoform 1","321",""
> "Q9CQA9-1","NP_001297617.1","cancer-related nucleoside-triphosphatase homolog isoform 2","121",""
> "Q8BRM2-1","NP_001300667.1","RAB6-interacting golgin isoform 2","213",""
> "Q6P3Z3-1","NP_001297690.1","THAP domain-containing protein 4 isoform 2","165",""
> "Q8K1L0-1","NP_001314750.1","cyclic AMP-responsive element-binding protein 5 isoform 1","501",""
6638c6616
< "Q8BJ52-1","NP_083701.2","phospholipid phosphatase-related protein type 5 isoform 2","316",""
---
> "Q8VEA8-1","NP_001298025.1","ras-related protein Rab-7b isoform 2","157",""
6640c6618
< "P59481-1","NP_001297446.1","VIP36-like protein isoform 1 precursor","358",""
---
> "Q641P0-1","NP_001004365.1","actin-related protein 3B isoform 1","418",""
6642d6619
< "Q8C9J3-1","NP_796097.2","sperm flagellar protein 2 isoform 2","875",""
6644,6646c6621
< "Q8BIS8-1","NP_780307.1","coiled-coil domain-containing protein 126 isoform 1 precursor","140",""
< "Q3TY65-1","NP_081683.3","islet cell autoantigen 1-like protein isoform a","431",""
< "Q711T7-1","NP_084497.1","glutamine-dependent NAD(+) synthetase isoform 1","725",""
---
> "Q8CI32-1","NP_001311409.1","BAG family molecular chaperone regulator 5","447",""
6648a6624,6625
> "Q9D2K4-1","NP_001298027.1","IQ domain-containing protein H isoform 1","1071",""
> "Q6PFX2-1","NP_001297413.1","BEN domain-containing protein 6 isoform 2","219",""
6650,6654c6627,6629
< "Q8BWB1-1","NP_780341.1","synaptopodin 2-like protein isoform 2","975",""
< "Q8K4Z0-1","NP_659194.1","leucine-rich repeat LGI family member 2 isoform 1 precursor","550",""
< "Q8BGI5-1","NP_083006.1","peroxisome assembly protein 26 isoform 1","305","This gene is a member of the peroxin-26 family. The encoded protein is probably required for protein import into peroxisomes. It may anchor Pex1 and Pex6 to peroxisome membranes. Defects in a similar gene in human are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2015]. "
< "Q6P5F7-1","NP_780483.2","protein tweety homolog 3 isoform 2","524",""
< "Q6P2L6-1","NP_001295411.1","histone-lysine N-methyltransferase NSD3 isoform 3","621","This gene encodes a member of the SET domain family of histone lysine N-methyltransferase proteins. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. It acts in opposition to the histone demethylase Jmjd1c. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2015]. "
---
> "Q9ESG4-1","NP_001300648.1","collectrin isoform 2","105",""
> "Q8C1A3-1","NP_001295404.1","methionine synthase reductase","696","Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Mutations in a similar gene in human have been associated with cblE complementation type homocystinuria-megaloblastic anemia and susceptibility to folate-sensitive neural tube defects. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2015]. "
> "Q8BHE1-1","NP_001297651.1","gem-associated protein 8 isoform 1","238",""
6657d6631
< "Q61476-1","NP_031853.2","complement decay-accelerating factor transmembrane isoform isoform 1 precursor","400","This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. This gene is located adjacent to a closely related gene on chromosome 1 and preferentially expressed in the spleen and testis. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2015]. "
6659,6660c6633,6635
< "P63042-1","NP_062649.1","stathmin-4 isoform 2","189",""
< "Q8VEA8-1","NP_663484.1","ras-related protein Rab-7b isoform 1","199",""
---
> "Q4VAB4-1","NP_001297440.1","protein canopy homolog 1","94",""
> "Q8BGI5-1","NP_001291702.1","peroxisome assembly protein 26 isoform 2","304","This gene is a member of the peroxin-26 family. The encoded protein is probably required for protein import into peroxisomes. It may anchor Pex1 and Pex6 to peroxisome membranes. Defects in a similar gene in human are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2015]. "
> "Q711T7-1","NP_001295024.1","glutamine-dependent NAD(+) synthetase isoform 3","479",""
6661a6637
> "Q3UR78-1","NP_001028630.2","neuropeptide-like protein C4orf48 homolog isoform 1","137",""
6663d6638
< "Q6P9N1-1","NP_444320.2","hyccin isoform 1","521",""
6664a6640,6642
> "Q8BMD6-1","NP_001297513.1","transmembrane protein 260 isoform 2","551",""
> "Q3UQU0-1","NP_001019679.2","bromodomain-containing protein 9 isoform 1","597",""
> "Q6TCG5-1","NP_001297526.1","membrane progestin receptor delta isoform 2","233",""
6665a6644
> "Q8C1Q6-1","NP_001295020.1","small integral membrane protein 4 isoform 2","80",""
6667c6646,6651
< "Q8K1K4-1","NP_666036.1","centromere protein I","746","This gene encodes a protein that may be constitutively associated with centromeres and might be involved in recruiting centromere protein A to the centromere for kinetochore assembly. A similar gene in human is involved in the response of gonadal tissues to follicle-stimulating hormone. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]. "
---
> "Q9CQP2-1","NP_001300651.1","trafficking protein particle complex subunit 2 isoform 2","72",""
> "Q6P2L6-1","NP_001001735.1","histone-lysine N-methyltransferase NSD3 isoform 1","655","This gene encodes a member of the SET domain family of histone lysine N-methyltransferase proteins. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. It acts in opposition to the histone demethylase Jmjd1c. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2015]. "
> "Q9D2G9-1","NP_001294981.1","HHIP-like protein 2 isoform 2","497",""
> "Q62252-1","NP_001311474.1","sperm surface protein Sp17","149",""
> "Q8C729-1","NP_001297527.1","protein FAM126B isoform a","586",""
> "Q9D2X0-1","NP_001297462.1","ankyrin repeat domain-containing protein 39 isoform 2","167",""
6670d6653
< "Q8BVN0-1","NP_780578.1","coiled-coil domain-containing protein 122 isoform 1","290",""
6672d6654
< "Q9CQP2-1","NP_079708.2","trafficking protein particle complex subunit 2 isoform 1","140",""
6674,6675c6656,6657
< "Q8VCB2-1","NP_083641.1","mediator of RNA polymerase II transcription subunit 25 isoform 1","745",""
< "Q3UR78-1","NP_001297476.1","neuropeptide-like protein C4orf48 homolog isoform 2 precursor","90",""
---
> "Q9CY62-1","NP_001318096.1","E3 ubiquitin-protein ligase RNF181 isoform 2","118",""
> "Q9D5K4-1","NP_001334132.1","S100P-binding protein isoform 2","277",""
6676a6659
> "Q8BIL2-1","NP_001297479.1","myb/SANT-like DNA-binding domain-containing protein 1 isoform 2","186",""
6678,6679c6661
< "Q8C1A3-1","NP_766068.1","methionine synthase reductase","696","Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Mutations in a similar gene in human have been associated with cblE complementation type homocystinuria-megaloblastic anemia and susceptibility to folate-sensitive neural tube defects. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2015]. "
< "Q9D1C8-1","NP_080118.1","vacuolar protein sorting-associated protein 28 homolog isoform 1","221","This gene encodes a protein which is thought to be a subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]. "
---
> "Q8BSN9-1","NP_001317352.1","FAST kinase domain-containing protein 3, mitochondrial","661",""
6681,6683d6662
< "O35609-1","NP_036016.2","secretory carrier-associated membrane protein 3 isoform 2","349",""
< "Q3UEG6-1","NP_001297665.1","alanine--glyoxylate aminotransferase 2, mitochondrial isoform 2","512",""
< "Q8BXJ2-1","NP_766210.1","transcriptional-regulating factor 1 isoform 2","1205",""
6684a6664,6665
> "Q8BXJ2-1","NP_001091092.1","transcriptional-regulating factor 1 isoform 1","1225",""
> "Q8VEK6-1","NP_001297990.1","inhibitor of growth protein 3 isoform 2","410",""
6685a6667,6668
> "B1AS42-1","NP_001333481.1","NADH-cytochrome b5 reductase-like isoform 1","316",""
> "Q8CH20-1","NP_001297390.1","cysteine-rich perinuclear theca protein 1 isoform 2","168",""
6687c6670
< "P58659-1","NP_081903.1","protein eva-1 homolog C isoform 2","392",""
---
> "P59481-1","NP_001013392.1","VIP36-like protein isoform 2 precursor","347",""
6688a6672
> "Q6P9N1-1","NP_001297400.1","hyccin isoform 2","370",""
6691,6694c6675
< "B1AS42-1","NP_780680.1","NADH-cytochrome b5 reductase-like isoform 2","256",""
< "Q8C5P5-1","NP_795942.2","5'-nucleotidase domain-containing protein 1 isoform 1","467",""
< "Q80W14-1","NP_061256.1","pre-mRNA-processing factor 40 homolog B isoform 2","873",""
< "Q9JM90-1","NP_064376.1","signal-transducing adaptor protein 1 isoform 1","297",""
---
> "Q91VH1-1","NP_001292998.1","adiponectin receptor protein 1","375","This gene encodes a receptor for the fat-derived hormone adiponectin. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. Homozygous knockout mice for this gene exhibit elevated plasma glucose and insulin levels as well as impaired glucose tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
6695a6677
> "Q505H4-1","NP_001297587.1","von Willebrand factor C domain-containing protein 2-like isoform 2 precursor","139",""
6697,6698c6679,6680
< "Q8BHE1-1","NP_666350.2","gem-associated protein 8 isoform 1","238",""
< "Q5DU31-1","NP_001334154.1","interactor protein for cytohesin exchange factors 1 isoform 5","410",""
---
> "Q8BWY2-1","NP_001334404.1","C-type lectin domain family 1 member A isoform 2","206",""
> "Q5RJ54-1","NP_001013808.2","zinc finger and SCAN domain-containing protein 26 isoform b","340",""
6699a6682
> "Q9R1S0-1","NP_001317709.1","B9 domain-containing protein 1 isoform 2 precursor","125",""
6700a6684
> "Q80V23-1","NP_001333576.1","zinc finger protein 32 isoform 1","286",""
6704d6687
< "Q99KR8-1","NP_080075.2","plasma alpha-L-fucosidase precursor","461",""
6706,6708c6689,6690
< "Q8BZ36-1","NP_796297.2","RAD50-interacting protein 1 isoform 1","792",""
< "Q5BU09-1","NP_079732.1","E2F-associated phosphoprotein isoform 1","281",""
< "Q3U2E2-1","NP_659091.3","zinc finger MYM-type protein 5","627",""
---
> "Q8C3X4-1","NP_001297560.1","translation factor Guf1, mitochondrial isoform 2","563",""
> "B7ZMP1-1","NP_001334004.1","xaa-Pro aminopeptidase 3 isoform 2","506",""
6710,6711c6692,6693
< "Q8C1Q6-1","NP_001295395.1","small integral membrane protein 4 isoform 3","86",""
< "Q8CH20-1","NP_080014.2","cysteine-rich perinuclear theca protein 1 isoform 1","173",""
---
> "Q99KR8-1","NP_001317127.1","plasma alpha-L-fucosidase precursor","461",""
> "Q3TFQ1-1","NP_001297532.1","SPRY domain-containing protein 7 isoform 2","163",""
6712a6695,6697
> "Q8K1K4-1","NP_001292560.1","centromere protein I","746","This gene encodes a protein that may be constitutively associated with centromeres and might be involved in recruiting centromere protein A to the centromere for kinetochore assembly. A similar gene in human is involved in the response of gonadal tissues to follicle-stimulating hormone. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]. "
> "Q8VCB2-1","NP_001318135.1","mediator of RNA polymerase II transcription subunit 25 isoform 2","778",""
> "Q6AW69-1","NP_001291291.1","cingulin-like protein 1","1297","This gene encodes a protein localized to the tight junctions and adherens junctions in vertebrate epithelial cells. The encoded protein regulates the activity of Rho family GTPases during junction assembly and at confluence. At the adherens junctions, the encoded protein is part of a protein complex that links E-cadherin to the microtubule cytoskeleton. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]. "
6713a6699
> "Q8R2Y0-1","NP_001317993.1","monoacylglycerol lipase ABHD6 isoform 1","336",""
6715,6717d6700
< "Q9D2G9-1","NP_084451.2","HHIP-like protein 2 isoform 1 precursor","717",""
< "Q3UMU9-1","NP_032259.1","hepatoma-derived growth factor-related protein 2 isoform 2","669",""
< "Q8BRM2-1","NP_849214.2","RAB6-interacting golgin isoform 1","368",""
6719,6721d6701
< "Q4FZD7-1","NP_898975.2","inactive serine/threonine-protein kinase PLK5 isoform 1","599",""
< "Q8R087-1","NP_666157.1","beta-1,4-galactosyltransferase 7 isoform 1","327",""
< "Q9CY62-1","NP_079883.3","E3 ubiquitin-protein ligase RNF181 isoform 1","165",""
6722a6703
> "Q9CQL1-1","NP_001314789.1","protein mago nashi homolog 2 isoform 2","102",""
6724,6725c6705,6708
< "Q641P0-1","NP_001297433.1","actin-related protein 3B isoform 2","330",""
< "Q8BSN9-1","NP_081399.3","FAST kinase domain-containing protein 3, mitochondrial","661",""
---
> "Q9D3D0-1","NP_001292732.1","alpha-tocopherol transfer protein-like isoform 2","337",""
> "Q91YN5-1","NP_001291974.1","UDP-N-acetylhexosamine pyrophosphorylase isoform 1","522",""
> "Q8CJG1-1","NP_001304102.1","protein argonaute-1 isoform 1x","895","This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]. "
> "Q9CQM6-1","NP_001297701.1","ankyrin repeat domain-containing protein 61 isoform 2","379",""
6728,6733c6711,6717
< "Q5RJ54-1","NP_001334420.1","zinc finger and SCAN domain-containing protein 26 isoform a","466",""
< "Q7TNC4-1","NP_619621.2","putative RNA-binding protein Luc7-like 2 isoform 1","392",""
< "O88495-1","NP_034470.1","melatonin-related receptor isoform 1","591","This gene encodes a multipass membrane protein that is thought to act as a G protein-coupled receptor. Activity of this protein may be important in neurotransmitter and glucocorticoid signalling. Mutation of this gene causes a decreased ability to maintain a constant body temperature, resulting in torpor, as well as an increased metabolic rate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]. "
< "Q6PDX6-1","NP_080015.3","E3 ubiquitin-protein ligase Rnf220 isoform 1","566",""
< "Q9R1S0-1","NP_038745.1","B9 domain-containing protein 1 isoform 1 precursor","204",""
< "Q7TNB4-1","NP_082017.2","protein maestro isoform 2","245",""
---
> "Q05A62-1","NP_001333457.1","dynein light chain 1, axonemal isoform 2","151",""
> "Q6PE87-1","NP_001333991.1","cilia- and flagella-associated protein 206 isoform 1","622",""
> "Q80TF4-1","NP_001277405.1","kelch-like protein 13 isoform 2","648",""
> "Q8BHR8-1","NP_001298073.1","UPF0705 protein C11orf49 homolog isoform 1","326",""
> "Q3V0Q6-1","NP_001007464.1","sperm-associated antigen 8 isoform 2","411",""
> "Q4FZD7-1","NP_001334053.1","inactive serine/threonine-protein kinase PLK5 isoform 2","595",""
> "Q3UEG6-1","NP_001297664.1","alanine--glyoxylate aminotransferase 2, mitochondrial isoform 1","513",""
6735c6719,6721
< "Q9D2K4-1","NP_084344.1","IQ domain-containing protein H isoform 2","1042",""
---
> "Q9CQQ0-1","NP_001317684.1","small integral membrane protein 8","97",""
> "Q9ESM6-1","NP_001292870.1","glycerophosphoinositol inositolphosphodiesterase GDPD2","539","This gene encodes a member of the glycerophosphodiester phosphodiesterase enzyme family. The encoded protein hydrolyzes glycerophosphoinositol to produce inositol 1-phosphate and glycerol. Overexpression of this gene is associated with activity-dependent actin cytoskeleton disorganization. The encoded protein may negatively regulate growth rate and induce differentiation of osteoblasts. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
> "Q7TNB4-1","NP_001292811.1","protein maestro isoform 1","246",""
6736a6723,6724
> "Q9CQ35-1","NP_001334086.1","GLIPR1-like protein 2 isoform 2","226",""
> "Q8CI85-1","NP_001293077.1","carbonic anhydrase 12 isoform 2 precursor","344","This gene encodes a membrane-bound member of the alpha carbonic anhydrase family of enzymes that catalyze the reversible hydration of carbon dioxide to bicarbonate. These proteins participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
6741,6742c6729
< "Q32NY4-1","NP_444416.2","metal transporter CNNM3 isoform 1 precursor","713",""
< "Q80V23-1","NP_808352.1","zinc finger protein 32 isoform 2","272",""
---
> "A8VU90-1","NP_001297431.1","ankyrin repeat and LEM domain-containing protein 1 isoform 2","514",""
6743a6731
> "O35609-1","NP_001296838.1","secretory carrier-associated membrane protein 3 isoform 1","350",""
6745,6748c6733,6745
< "Q6TXD4-1","NP_082305.1","dynamin-binding protein isoform 1","1580","This gene encodes a member of the DBL family of guanine nucleotide exchange factors. The encoded protein has been proposed to regulate the actin cytoskeleton by specifically activating the Rho-family GTPase Cdc42. An interaction between the encoded protein and a Listeria protein has been shown to mediate Listeria infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
< "Q3UN58-1","NP_001334191.1","Fanconi anemia core complex-associated protein 20 isoform b","173",""
< "A2RTL5-1","NP_079714.1","arginine/serine-rich coiled-coil protein 2 isoform 2","376",""
< "Q8BZI6-1","NP_780342.1","protein GUCD1 isoform 1","239",""
---
> "Q9JM90-1","NP_001297568.1","signal-transducing adaptor protein 1 isoform 2","259",""
> "Q8BVN7-1","NP_001333456.1","solute carrier family 25 member 41 isoform 2","298",""
> "A7TZF0-1","NP_001095944.1","selection and upkeep of intraepithelial T-cells protein 3 isoform a precursor","458",""
> "P10853-1","NP_001300807.1","histone cluster 1 H2br isoform 2","126","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Sep 2015]. "
> "Q69Z89-1","NP_001297681.1","ras-associating and dilute domain-containing protein isoform 3","1099",""
> "Q7TNC4-1","NP_001164320.1","putative RNA-binding protein Luc7-like 2 isoform 3","325",""
> "Q9DAU9-1","NP_001334174.1","zinc finger protein 654","1112",""
> "P58659-1","NP_001186139.1","protein eva-1 homolog C isoform 1 precursor","440",""
> "Q9D2L9-1","NP_001333474.1","protein FAM111A isoform 2","569",""
> "Q61476-1","NP_001304290.1","complement decay-accelerating factor transmembrane isoform isoform 2 precursor","287","This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. This gene is located adjacent to a closely related gene on chromosome 1 and preferentially expressed in the spleen and testis. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2015]. "
> "Q8BG81-1","NP_001334011.1","polymerase delta-interacting protein 3 isoform 2","391",""
> "Q8BZI6-1","NP_001334130.1","protein GUCD1 isoform 2","200",""
> "P63042-1","NP_001297451.1","stathmin-4 isoform 1","216",""
6750d6746
< "Q3UA16-1","NP_079841.1","kinetochore protein Spc25 isoform 2","178","This gene encodes a component of the kinetochore-associated NDC80 protein complex, which is required for the mitotic spindle checkpoint and for microtubule-kinetochore attachment. During meiosis in mouse, the protein localizes to the germinal vesicle and then is associated with the chromosomes following germinal vesicle breakdown. Knockdown of this gene in oocytes results in precocious polar body extrusion, chromosome misalignment and aberrant spindle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
6752c6748,6751
< "Q4VAB4-1","NP_001297441.1","protein canopy homolog 1","94",""
---
> "Q9DA32-1","NP_001291977.1","SUN domain-containing protein 5 isoform 1","373",""
> "Q8K2Z8-1","NP_001333587.1","ubiquitin-conjugating enzyme E2 Q2 isoform 3","255",""
> "Q32NY4-1","NP_001034640.1","metal transporter CNNM3 isoform 2 precursor","708",""
> "Q8VCE9-1","NP_001333698.1","pleckstrin homology domain-containing family H member 3 isoform 2 precursor","793",""
6755,6756c6754
< "Q8C3X4-1","NP_766299.1","translation factor Guf1, mitochondrial isoform 1","651",""
< "Q9CQQ0-1","NP_079747.1","small integral membrane protein 8","97",""
---
> "Q8BNL5-1","NP_001292865.1","BTB/POZ domain-containing protein KCTD6","237",""
6765a6764
> "Q924Z6-1","NP_001298072.1","exportin-6 isoform 1","1125",""
6766a6766
> "O54965-1","NP_001106884.1","E3 ubiquitin-protein ligase RNF13 isoform a precursor","381","This gene encodes a member of the PA-TM-RING family of proteins that contain a protease associated (PA) domain and a RING finger domain separated by a transmembrane (TM) domain. The encoded protein is an E3 ubiquitin ligase localized to the endosomal-lysosomal vesicles and inner nuclear membrane. Mice lacking the encoded protein have impaired learning abilities associated with a decreased synaptic vesicle density and dysregulated SNARE complex assembly. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on the X chromosome. [provided by RefSeq, Jan 2015]. "
6768a6769
> "Q9CQV4-1","NP_080777.1","reticulophagy regulator 3 isoform 1","466",""
6775,6776d6775
< "Q99KG3-1","NP_663602.1","RNA-binding protein 10 isoform 1","930",""
< "Q6PI62-1","NP_081819.2","probable G-protein coupled receptor 173","373",""
6785d6783
< "Q9D832-1","NP_081563.2","dnaJ homolog subfamily B member 4 isoform 1","337",""
6788d6785
< "Q9D7S7-1","NP_080793.1","60S ribosomal protein L22-like 1 isoform 1","122",""
6790d6786
< "O54965-1","NP_036013.1","E3 ubiquitin-protein ligase RNF13 isoform b precursor","268","This gene encodes a member of the PA-TM-RING family of proteins that contain a protease associated (PA) domain and a RING finger domain separated by a transmembrane (TM) domain. The encoded protein is an E3 ubiquitin ligase localized to the endosomal-lysosomal vesicles and inner nuclear membrane. Mice lacking the encoded protein have impaired learning abilities associated with a decreased synaptic vesicle density and dysregulated SNARE complex assembly. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on the X chromosome. [provided by RefSeq, Jan 2015]. "
6797d6792
< "Q768S4-1","NP_083824.1","rab effector Noc2 isoform 1","302",""
6806c6801
< "Q99MB2-1","NP_080458.1","mitochondrial fission regulator 1","328",""
---
> "Q6PI62-1","NP_001300677.1","probable G-protein coupled receptor 173","373",""
6824a6820
> "Q8VD24-1","NP_001030586.1","zinc finger CCHC domain-containing protein 18","393",""
6829a6826
> "Q99NC0-1","NP_001300692.1","transcription cofactor vestigial-like protein 1","307",""
6832c6829
< "Q8BFU3-1","NP_848824.1","RING finger protein 214 isoform 1","668",""
---
> "Q768S4-1","NP_001278088.1","rab effector Noc2 isoform 2","141",""
6841d6837
< "Q99NC0-1","NP_573514.1","transcription cofactor vestigial-like protein 1","307",""
6843d6838
< "Q8BFR6-1","NP_079788.2","AN1-type zinc finger protein 1 isoform 1","268",""
6847a6843
> "Q99KG3-1","NP_001161247.1","RNA-binding protein 10 isoform 2","929",""
6858d6853
< "Q922U1-1","NP_081817.2","U4/U6 small nuclear ribonucleoprotein Prp3","683",""
6861a6857
> "Q8BZ98-1","NP_001033708.1","dynamin-3 isoform 1","863",""
6868a6865
> "Q9D832-1","NP_080202.1","dnaJ homolog subfamily B member 4 isoform 1","337",""
6870a6868
> "Q80ZU9-1","NP_001170831.1","integral membrane protein GPR137 isoform 2","304",""
6871a6870
> "Q922U1-1","NP_001303680.1","U4/U6 small nuclear ribonucleoprotein Prp3","683",""
6873d6871
< "Q8BZ98-1","NP_766234.1","dynamin-3 isoform 2","859",""
6874a6873
> "Q99LI2-1","NP_001171242.1","chloride channel CLIC-like protein 1 isoform 2 precursor","539",""
6877a6877
> "Q99MB2-1","NP_001240319.1","mitochondrial fission regulator 1","328",""
6879a6880
> "Q9D7S7-1","NP_001334155.1","60S ribosomal protein L22-like 1 isoform 2","121",""
6883,6884d6883
< "Q924Z6-1","NP_083092.2","exportin-6 isoform 2","1124",""
< "P58058-1","NP_619612.2","NAD kinase isoform 1","439",""
6888d6886
< "Q8VDV3-1","NP_653121.1","guanine nucleotide exchange factor for Rab-3A isoform 1","383",""
6895d6892
< "Q8BG81-1","NP_848742.1","polymerase delta-interacting protein 3 isoform 1","420",""
6897d6893
< "Q91WJ7-1","NP_659131.2","SPATS2-like protein isoform 1","578",""
6907a6904
> "Q8CHB8-1","NP_001074892.2","tubulin polyglutamylase TTLL5 isoform 1","1328",""
6909d6905
< "Q80WC3-1","NP_839973.1","trinucleotide repeat-containing gene 18 protein isoform B","1755",""
6911d6906
< "Q3UFY7-1","NP_080837.3","7-methylguanosine phosphate-specific 5'-nucleotidase isoform 2","261",""
6912a6908
> "Q80WC3-1","NP_001116202.2","trinucleotide repeat-containing gene 18 protein isoform A","2855",""
6934d6929
< "Q8CHB8-1","NP_001334324.1","tubulin polyglutamylase TTLL5 isoform 2","1295",""
6943a6939
> "Q3UFY7-1","NP_001096120.1","7-methylguanosine phosphate-specific 5'-nucleotidase isoform 1","300",""
6953d6948
< "Q80ZU9-1","NP_997103.1","integral membrane protein GPR137 isoform 1","396",""
6967d6961
< "Q9Z2H5-1","NP_038538.1","band 4.1-like protein 1 isoform a","879",""
6977d6970
< "Q8BR63-1","NP_082803.1","protein FAM177A1","207",""
6994a6988
> "Q80Y83-1","NP_001297998.1","dixin isoform 2","710",""
6996a6991,6992
> "Q400C8-1","NP_001239122.1","archaemetzincin-2","363",""
> "Q6PCP5-1","NP_001297624.1","mitochondrial fission factor isoform 2","239",""
6998d6993
< "Q400C8-1","NP_079551.3","archaemetzincin-2","363",""
7000d6994
< "Q80Y83-1","NP_835219.1","dixin isoform 1","711",""
7002d6995
< "Q811C2-1","NP_778194.3","cysteine protease ATG4C","458",""
7003a6997,6998
> "Q811C2-1","NP_001139439.1","cysteine protease ATG4C","458",""
> "Q791V5-1","NP_001304170.1","mitochondrial carrier homolog 2 isoform 1x","314","This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]. "
7005d6999
< "Q8BHG2-1","NP_083030.1","CXXC motif containing zinc binding protein isoform 1","196",""
7006a7001
> "Q8CEZ4-1","NP_001153412.1","protein mab-21-like 4","452",""
7008c7003
< "Q8CEZ4-1","NP_765999.3","protein mab-21-like 4","452",""
---
> "Q8BHG2-1","NP_001334089.1","CXXC motif containing zinc binding protein isoform 2","160",""
7022d7016
< "Q9D4J7-1","NP_081918.1","PHD finger protein 6 isoform 1","364",""
7026a7021
> "Q9D4J7-1","NP_001277475.1","PHD finger protein 6 isoform 2","284",""
7034a7030
> "O88689-1","NP_001167625.1","protocadherin alpha 4-gamma precursor","919",""
7037c7033
< "A2AIP0-1","NP_796351.2","protein FAM166B isoform 1","379",""
---
> "A2AIP0-1","NP_001155853.1","protein FAM166B isoform 2","245",""
7042a7039
> "P59862-1","NP_001278118.1","cadherin-like protein 26 isoform b precursor","744",""
7045d7041
< "P59862-1","NP_941058.1","cadherin-like protein 26 isoform a precursor","763",""
7050a7047
> "Q8K595-1","NP_001005846.1","mucolipin-2 isoform 2","538",""
7084d7080
< "Q8K595-1","NP_080932.2","mucolipin-2 isoform 1","566",""
7100a7097
> "P17182-1","NP_001020559.1","enolase 1B, retrotransposed","434","This gene may represent an evolving pseudogene of the alpha-enolase (enolase 1, alpha non-neuron) gene, which has multiple pseudogenes. This gene has an intact open reading frame as well as strong transcriptional support. The length of encoded protein is conserved, compared to the original enolase 1 protein. The exact function of this gene is unknown. [provided by RefSeq, Jul 2008]. "
7109a7107
> "Q5FWD4-1","NP_001153614.1","uncharacterized protein LOC100041256","227",""
7112,7114c7110,7111
< "Q5FWD4-1","NP_001153616.1","uncharacterized protein LOC100039810","227",""
< "A6PWY4-1","NP_084510.2","WD repeat-containing protein 76 isoform a","524",""
< "Q8BGW0-1","NP_848781.1","protein THEMIS isoform 1","636","This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]. "
---
> "A6PWY4-1","NP_001277915.1","WD repeat-containing protein 76 isoform a","524",""
> "Q8BGW0-1","NP_001292592.1","protein THEMIS isoform 2","512","This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]. "
7117d7113
< "Q91WD0-1","NP_084360.2","protein GPR108 isoform 1 precursor","569",""
7121d7116
< "Q8BT07-1","NP_083036.2","centrosomal protein of 55 kDa isoform 2","461",""
7129d7123
< "Q9D6Z0-1","NP_081648.1","alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial isoform 2","163",""
7131c7125
< "O35309-1","NP_062274.1","N-myc-interactor","314",""
---
> "Q9D6Z0-1","NP_079814.1","alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial isoform 1 precursor","221",""
7134d7127
< "Q8BJA3-1","NP_796312.2","homeobox-containing protein 1 isoform 2","419",""
7135a7129
> "O35309-1","NP_001135420.1","N-myc-interactor","314",""
7138c7132
< "O70514-1","NP_032035.2","fibroblast growth factor-binding protein 1 precursor","251",""
---
> "O70514-1","NP_001258545.1","fibroblast growth factor-binding protein 1 precursor","251",""
7145,7146d7138
< "Q8CJ00-1","NP_757341.3","NADPH oxidase activator 1 isoform 1","444",""
< "Q8K2F3-1","NP_666092.1","protein DEPP1","205",""
7147a7140,7141
> "Q9Z2H6-1","NP_001156633.1","C-type lectin domain family 4 member D isoform 2","218",""
> "Q923X4-1","NP_001033681.1","glutaredoxin-2, mitochondrial isoform a","156",""
7148a7143
> "Q8K2F3-1","NP_001160052.1","protein DEPP1","205",""
7151d7145
< "Q923X4-1","NP_075994.2","glutaredoxin-2, mitochondrial isoform b","123",""
7154d7147
< "Q9Z2H6-1","NP_034949.3","C-type lectin domain family 4 member D isoform 1","219",""
7158c7151,7152
< "Q9D658-1","NP_033001.2","protein tyrosine phosphatase type IVA 3 isoform 1","173",""
---
> "Q8CJ00-1","NP_001157098.1","NADPH oxidase activator 1 isoform 2","436",""
> "Q9D658-1","NP_001159860.1","protein tyrosine phosphatase type IVA 3 isoform 1","173",""
7167,7168c7161
< "Q6NZQ8-1","NP_780397.2","E3 ubiquitin-protein ligase MARCH1 isoform 3","285",""
< "Q8BZT2-1","NP_766554.2","E3 ubiquitin-protein ligase SH3RF2 isoform 2","703",""
---
> "Q6NZQ8-1","NP_001159844.1","E3 ubiquitin-protein ligase MARCH1 isoform 1","285",""
7172c7165,7166
< "Q5M8Q2-1","NP_001229883.1","histone cluster 2 family member","105",""
---
> "Q8BZT2-1","NP_001139771.1","E3 ubiquitin-protein ligase SH3RF2 isoform 1","735",""
> "Q65CL1-1","NP_001157848.1","catenin alpha-3 isoform 1","895",""
7174d7167
< "Q8BHI4-1","NP_081238.2","kelch repeat and BTB domain-containing protein 3","607",""
7176d7168
< "Q65CL1-1","NP_808280.2","catenin alpha-3 isoform 1","895",""
7179,7180c7171,7173
< "Q8BXQ6-1","NP_001276855.1","aminopeptidase O","823",""
< "Q499E4-1","NP_082534.2","zinc finger protein DZIP1L isoform 1","774",""
---
> "Q3ULW8-1","NP_001298079.1","protein mono-ADP-ribosyltransferase PARP3 isoform 1","533",""
> "Q8BXQ6-1","NP_001276853.1","aminopeptidase O","823",""
> "Q499E4-1","NP_001298071.1","zinc finger protein DZIP1L isoform 2","773",""
7182d7174
< "Q7TPG7-1","NP_877959.2","chemokine-like protein TAFA-2 isoform 1","135","This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]. "
7192d7183
< "Q3ULW8-1","NP_663594.2","protein mono-ADP-ribosyltransferase PARP3 isoform 2","528",""
7205a7197
> "Q8BZL1-2","NP_001297698.1","sialidase-4 isoform 1","501",""
7208a7201
> "Q91WT8-1","NP_001120854.1","RNA-binding protein 47 isoform a","590",""
7211d7203
< "Q91WT8-1","NP_848541.2","RNA-binding protein 47 isoform a","590",""
7214d7205
< "Q8R331-1","NP_081594.1","zinc finger HIT domain-containing protein 1 isoform 1","153",""
7216d7206
< "Q8BZL1-2","NP_776133.1","sialidase-4 isoform 2","478",""
7227a7218
> "Q9CXF0-1","NP_001276522.1","kynureninase isoform 2","428",""
7231,7232c7222
< "Q9D1G2-1","NP_081624.1","phosphomevalonate kinase isoform 2","171",""
< "Q9CXF0-1","NP_081828.1","kynureninase isoform 1","465",""
---
> "Q0VBL6-1","NP_001156422.1","hypoxia-inducible factor 3-alpha isoform 1","664",""
7235d7224
< "Q0VBL6-1","NP_058564.2","hypoxia-inducible factor 3-alpha isoform 2","662",""
7237a7227
> "Q9D1G2-1","NP_001297569.1","phosphomevalonate kinase isoform 3","117",""
7242c7232
< "P57787-1","NP_109621.1","monocarboxylate transporter 4","470",""
---
> "P57787-1","NP_001033742.1","monocarboxylate transporter 4","470",""
7249a7240,7241
> "Q8C0Y1-1","NP_001278053.1","homeobox protein TGIF2 isoform b","198",""
> "Q09M02-1","NP_001041657.1","cytosolic carboxypeptidase-like protein 5 isoform 3","846",""
7252a7245
> "Q8QZR3-1","NP_001177259.1","pyrethroid hydrolase Ces2a isoform 2 precursor","525",""
7258c7251
< "Q8QZR3-1","NP_598721.1","pyrethroid hydrolase Ces2a isoform 1 precursor","558",""
---
> "Q6IR34-1","NP_001186075.1","G-protein-signaling modulator 1 isoform 2","613",""
7260c7253
< "Q09M02-1","NP_777274.1","cytosolic carboxypeptidase-like protein 5 isoform 5","719",""
---
> "Q07139-1","NP_001171096.1","protein ECT2 isoform 2","882",""
7263,7264d7255
< "Q6IR34-1","NP_700459.2","G-protein-signaling modulator 1 isoform 1","673",""
< "Q07139-1","NP_031926.2","protein ECT2 isoform 1","913",""
7266c7257
< "Q8C0Y1-1","NP_775572.1","homeobox protein TGIF2 isoform a","237",""
---
> "Q8BIX3-1","NP_001020273.1","ARL14 effector protein","276",""
7268d7258
< "Q9QXC1-1","NP_067539.1","fetuin-B isoform 1 precursor","388",""
7275a7266
> "Q9ESJ7-1","NP_001161712.1","interleukin-1 receptor-associated kinase 1-binding protein 1 isoform 2","237",""
7279d7269
< "Q640P7-1","NP_001303675.1","TBCC domain-containing protein 1","552",""
7285,7286d7274
< "Q8CHZ9-1","NP_742147.1","transcription termination factor 1a, mitochondrial precursor","379",""
< "Q8BP86-1","NP_758842.1","snRNA-activating protein complex subunit 4 isoform a","1325",""
7294d7281
< "Q80W88-1","NP_898997.2","homeobox and leucine zipper protein Homez","518",""
7295a7283
> "Q8CHZ9-1","NP_001013041.2","transcription termination factor 1a, mitochondrial precursor","379",""
7297d7284
< "Q9ESJ7-1","NP_075362.3","interleukin-1 receptor-associated kinase 1-binding protein 1 isoform 1","259",""
7305a7293,7295
> "Q80ZD9-1","NP_001158035.1","amphoterin-induced protein 2 precursor","519",""
> "Q02395-1","NP_001240806.1","metal-response element-binding transcription factor 2 isoform 2","491",""
> "Q91X97-1","NP_001164337.1","neurocalcin-delta","193",""
7308d7297
< "Q91X97-1","NP_598855.2","neurocalcin-delta","193",""
7313d7301
< "Q80ZD9-1","NP_835215.1","amphoterin-induced protein 2 precursor","519",""
7317d7304
< "Q02395-1","NP_038855.2","metal-response element-binding transcription factor 2 isoform 1","593",""
7325c7312,7313
< "Q61161-1","NP_033032.1","mitogen-activated protein kinase kinase kinase kinase 2 isoform 1","821",""
---
> "Q61161-1","NP_001278716.1","mitogen-activated protein kinase kinase kinase kinase 2 isoform 2","732",""
> "Q8BUY8-1","NP_001156487.1","G-protein coupled receptor-associated sorting protein 2","826",""
7329d7316
< "Q8BNI4-1","NP_291040.1","derlin-2 isoform a","239",""
7332d7318
< "Q68FL4-1","NP_067389.5","putative adenosylhomocysteinase 3 isoform 1","613",""
7335,7336d7320
< "Q8R4D1-1","NP_683731.1","sodium/hydrogen exchanger 8 isoform a","576","This gene encodes a member of the Na+/H+ exchanger (NHE) family of integral membrane transporter proteins. The encoded protein is expressed on the apical membrane of the intestinal epithelial cells and plays an important role in mucosal protection. Loss of the encoded protein in mice results in a decrease in the number of goblet and mucin-positive cells, disorganization of the mucin layer, and a decrease in mucosal pH in the colon. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]. "
< "Q8BUY8-1","NP_001156489.1","G-protein coupled receptor-associated sorting protein 2","826",""
7339a7324,7325
> "Q8R4D1-1","NP_001291469.1","sodium/hydrogen exchanger 8 isoform c","482","This gene encodes a member of the Na+/H+ exchanger (NHE) family of integral membrane transporter proteins. The encoded protein is expressed on the apical membrane of the intestinal epithelial cells and plays an important role in mucosal protection. Loss of the encoded protein in mice results in a decrease in the number of goblet and mucin-positive cells, disorganization of the mucin layer, and a decrease in mucosal pH in the colon. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]. "
> "Q8BNI4-1","NP_001278075.1","derlin-2 isoform b","165",""
7348a7335
> "Q68FL4-1","NP_001164471.2","putative adenosylhomocysteinase 3 isoform 2","612",""
7362c7349
< "Q9D5R4-1","NP_081893.1","spermatogenesis-associated protein 1 isoform 1","444",""
---
> "Q9D5R4-1","NP_001303685.1","spermatogenesis-associated protein 1 isoform 1","444",""
7364a7352
> "B5KM66-1","NP_001156352.1","synaptonemal complex central element protein 3","88",""
7366d7353
< "O35714-1","NP_068820.1","tumor necrosis factor receptor superfamily member 18 isoform 2 precursor","132",""
7368d7354
< "Q61907-1","NP_032845.2","phosphatidylethanolamine N-methyltransferase isoform b","199",""
7370a7357
> "O35714-1","NP_033426.1","tumor necrosis factor receptor superfamily member 18 isoform 1 precursor","228",""
7373d7359
< "Q9Z206-1","NP_062645.2","neuroepithelial cell-transforming gene 1 protein isoform 1","595",""
7376d7361
< "B5KM66-1","NP_001156354.1","synaptonemal complex central element protein 3","88",""
7378a7364
> "Q9Z206-1","NP_001040624.1","neuroepithelial cell-transforming gene 1 protein isoform 2","541",""
7383a7370
> "Q61907-1","NP_001276940.1","phosphatidylethanolamine N-methyltransferase isoform a","236",""
7386,7388c7373
< "Q3TYD4-1","NP_082986.3","arylsulfatase G isoform 1 precursor","525",""
< "Q8BHN3-1","NP_032086.1","neutral alpha-glucosidase AB isoform 1","966",""
< "O35969-1","NP_034385.1","guanidinoacetate N-methyltransferase isoform 1","236",""
---
> "Q3TYD4-1","NP_001159649.1","arylsulfatase G isoform 2","202",""
7390d7374
< "Q148V7-1","NP_775279.2","RAB11-binding protein RELCH isoform 1","1216",""
7391a7376,7378
> "O35969-1","NP_001334048.1","guanidinoacetate N-methyltransferase isoform 2","252",""
> "Q148V7-1","NP_083625.1","RAB11-binding protein RELCH isoform 2","1192",""
> "Q99PU8-1","NP_001239611.1","ATP-dependent RNA helicase DHX30 isoform 1","1194",""
7393d7379
< "Q99PU8-1","NP_579925.1","ATP-dependent RNA helicase DHX30 isoform 2","1217",""
7397a7384,7385
> "P42567-1","NP_001153436.1","epidermal growth factor receptor substrate 15 isoform B","583",""
> "Q08509-1","NP_001258516.1","epidermal growth factor receptor kinase substrate 8 isoform 2","847",""
7401a7390,7391
> "Q9WTS2-1","NP_001239543.1","alpha-(1,6)-fucosyltransferase isoform 1","575",""
> "P59672-1","NP_001272970.1","ankyrin repeat and SAM domain-containing protein 1A isoform 2","1168",""
7403c7393,7394
< "Q6P549-1","NP_034697.2","phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2","1257",""
---
> "Q6P549-1","NP_001116211.1","phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2","1257",""
> "Q9JLI2-1","NP_001304317.1","collagen alpha-3(V) chain isoform 2 precursor","1738",""
7411,7412d7401
< "Q91Y82-1","NP_035307.2","kallikrein-6 precursor","253",""
< "Q08509-1","NP_031971.2","epidermal growth factor receptor kinase substrate 8 isoform 1","821",""
7414,7415d7402
< "Q9JLI2-1","NP_058615.1","collagen alpha-3(V) chain isoform 1 precursor","1739",""
< "P42567-1","NP_031969.1","epidermal growth factor receptor substrate 15 isoform A","897",""
7419,7420c7406
< "Q75N73-1","NP_659057.2","zinc transporter ZIP14 isoform b precursor","489",""
< "Q8CII9-1","NP_057924.3","cytokine receptor-like factor 2 isoform 2 precursor","359",""
---
> "Q91Y82-1","NP_001158168.1","kallikrein-6 precursor","253",""
7424a7411,7412
> "Q8CII9-1","NP_001158207.1","cytokine receptor-like factor 2 isoform 1 precursor","370",""
> "Q9Z0R4-1","NP_001103745.1","intersectin-1 isoform 2","1213",""
7426,7427c7414
< "Q3UMW7-1","NP_849238.1","MAP kinase-activated protein kinase 3 isoform 1","384",""
< "Q9Z0R4-1","NP_034717.2","intersectin-1 isoform 1","1714",""
---
> "Q75N73-1","NP_001128623.1","zinc transporter ZIP14 isoform a precursor","489",""
7430a7418
> "Q64700-1","NP_001268929.1","retinoblastoma-like protein 2 isoform 2","1092",""
7433d7420
< "P59672-1","NP_852078.1","ankyrin repeat and SAM domain-containing protein 1A isoform 3","1150",""
7435,7437c7422,7423
< "Q9WTS2-1","NP_058589.2","alpha-(1,6)-fucosyltransferase isoform 1","575",""
< "Q60875-1","NP_032513.3","rho guanine nucleotide exchange factor 2 isoform 1","985",""
< "Q64700-1","NP_035380.3","retinoblastoma-like protein 2 isoform 1","1135",""
---
> "Q60875-1","NP_001185840.1","rho guanine nucleotide exchange factor 2 isoform 2","968",""
> "Q3UMW7-1","NP_001303620.1","MAP kinase-activated protein kinase 3 isoform 2","266",""
7439,7440c7425,7426
< "Q920A9-1","NP_660123.1","Fc receptor-like A isoform 2 precursor","352",""
< "Q91X45-1","NP_598520.1","zinc finger and BTB domain-containing protein 3","518",""
---
> "Q920A9-1","NP_001153687.1","Fc receptor-like A isoform 1 precursor","353",""
> "Q91X45-1","NP_001091707.1","zinc finger and BTB domain-containing protein 3","518",""
7443d7428
< "Q2M2N2-1","NP_084049.2","speckle-type POZ protein-like isoform a","392",""
7447a7433
> "Q2M2N2-1","NP_001159469.1","speckle-type POZ protein-like isoform b","317",""
7450a7437
> "Q5DTT2-1","NP_001334383.1","PH and SEC7 domain-containing protein 1 isoform 2","1025",""
7454c7441
< "Q61335-1","NP_036190.2","B-cell receptor-associated protein 31","245",""
---
> "Q9D8T0-1","NP_001300654.1","protein FAM3A precursor","230",""
7465,7466c7452,7456
< "Q80U72-1","NP_598850.1","protein scribble homolog isoform 1","1665",""
< "Q9D8T0-1","NP_079749.1","protein FAM3A precursor","230",""
---
> "P51908-1","NP_001127863.1","C->U-editing enzyme APOBEC-1","229",""
> "Q80XN0-1","NP_001116155.1","D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor","343",""
> "Q61335-1","NP_001300627.1","B-cell receptor-associated protein 31","245",""
> "Q80U72-1","NP_001297471.1","protein scribble homolog isoform 2","1637",""
> "Q5XJV7-1","NP_082661.1","histone-lysine N-methyltransferase SETD5 isoform 1","1441",""
7468,7469d7457
< "Q80XN0-1","NP_780386.3","D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor","343",""
< "P51908-1","NP_112436.1","C->U-editing enzyme APOBEC-1","229",""
7471d7458
< "Q5DTT2-1","NP_082903.2","PH and SEC7 domain-containing protein 1 isoform 1","1024",""
7478c7465
< "Q78KK3-1","NP_032793.2","solute carrier family 22 member 18","410",""
---
> "Q78KK3-1","NP_001036225.1","solute carrier family 22 member 18","410",""
7483a7471
> "A1A5B6-1","NP_001159909.1","TBC1 domain family member 25 isoform 2","723",""
7486c7474
< "Q9EPQ1-1","NP_109607.1","toll-like receptor 1 precursor","795",""
---
> "Q9EPQ1-1","NP_001263374.1","toll-like receptor 1 precursor","795",""
7487a7476
> "Q6Y685-1","NP_796063.3","transforming acidic coiled-coil-containing protein 1 long isoform","776",""
7489d7477
< "Q6Y685-1","NP_955355.1","transforming acidic coiled-coil-containing protein 1 short isoform","368",""
7491a7480
> "A2ATW2-1","NP_001257352.1","olfactory receptor 1506-like","309","Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2012]. "
7496d7484
< "Q9CQ94-1","NP_079765.3","dnaJ homolog subfamily C member 5B","199",""
7503d7490
< "Q3TB92-1","NP_001258304.1","allergin-1 isoform d","208",""
7508a7496
> "Q9CQ94-1","NP_001157008.1","dnaJ homolog subfamily C member 5B","199",""
7517a7506
> "Q3TB92-1","NP_001028607.1","allergin-1 isoform a precursor","246",""
7520d7508
< "Q9WV76-1","NP_080469.2","AP-4 complex subunit beta-1 isoform a","738",""
7523a7512,7513
> "Q80V86-1","NP_001153067.1","integrator complex subunit 8","995",""
> "Q9DBV3-1","NP_001272860.1","probable ATP-dependent RNA helicase DHX34","1145",""
7526d7515
< "Q80V86-1","NP_835213.3","integrator complex subunit 8","995",""
7527a7517
> "Q6ZPK0-10","NP_001103161.1","PHD finger protein 21A isoform 3","604",""
7530a7521
> "Q8BVD5-1","NP_001074756.2","MAGUK p55 subfamily member 7 isoform 1","576",""
7533a7525
> "Q62172-1","NP_001185878.1","ralA-binding protein 1","648",""
7540a7533
> "Q8BFY9-1","NP_001041732.1","transportin-1 isoform 2","890",""
7543,7544d7535
< "Q8BK06-1","NP_076094.2","F-box only protein 9 isoform 1","436",""
< "Q922M3-1","NP_080421.2","BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 2","315",""
7555c7546
< "Q9DBV3-1","NP_082159.3","probable ATP-dependent RNA helicase DHX34","1145",""
---
> "Q9QZ85-1","NP_001139747.1","interferon-inducible GTPase 1","413",""
7560d7550
< "Q9DAJ2-1","NP_035699.2","tektin-1","418",""
7564,7565d7553
< "Q8C8U0-1","NP_080497.1","liprin-beta-1 isoform 2","969",""
< "Q7TSJ2-1","NP_034967.2","microtubule-associated protein 6 isoform 1","906",""
7566a7555
> "Q4LDD4-1","NP_001035200.1","arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform 3","1441",""
7568a7558
> "Q922M3-1","NP_001153413.1","BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 1","316",""
7572d7561
< "Q9QXS1-1","NP_958796.2","plectin isoform 1a","4543","Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as 'hemidesmosomal protein 1' or 'plectin 1, intermediate filament binding 500kDa'. These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). It has been shown that the short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (human variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. [provided by RefSeq, Aug 2011]. "
7575c7564
< "Q9CQC4-1","NP_081074.1","transmembrane protein 216 isoform 2","87","This gene encodes a transmembrane protein which is involved in regulation of signaling and trafficking of associated proteins. In humans, mutations in this gene are associated with ciliopathies including Joubert, Meckel and related syndromes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]. "
---
> "P32067-1","NP_001103615.1","lupus La protein homolog isoform a","415",""
7577,7578c7566
< "Q8K4G1-1","NP_783572.2","latent-transforming growth factor beta-binding protein 4 isoform a precursor","1666",""
< "Q3LRV9-1","NP_766211.2","trem-like transcript 4 protein isoform 2 precursor","263",""
---
> "P70347-1","NP_001157544.1","TRAF family member-associated NF-kappa-B activator isoform 2","413",""
7581c7569
< "Q9DBR3-1","NP_083044.2","armadillo repeat-containing protein 8 isoform 1","673",""
---
> "Q99J47-1","NP_001165583.1","dehydrogenase/reductase SDR family member 7B isoform 1","314",""
7583c7571
< "Q9CY27-1","NP_598879.1","very-long-chain enoyl-CoA reductase isoform 1","308",""
---
> "P40336-1","NP_001106826.1","vacuolar protein sorting-associated protein 26A isoform b","359",""
7587a7576,7577
> "Q8C726-1","NP_081336.1","BTB/POZ domain-containing protein 9","612",""
> "Q9JL26-1","NP_001071166.1","formin-like protein 1 isoform 2","1094",""
7589d7578
< "P59325-1","NP_829887.1","eukaryotic translation initiation factor 5","429",""
7592c7581,7582
< "S4R2V3-1","NP_001268453.1","secretoglobin, family 2B, member 17 precursor","82",""
---
> "Q8VDK3-1","NP_001139285.1","ETS-related transcription factor Elf-5","253",""
> "Q9DAJ2-1","NP_001268935.1","tektin-1","418",""
7595d7584
< "Q80TZ3-1","NP_940804.1","putative tyrosine-protein phosphatase auxilin isoform c","900",""
7597a7587,7588
> "Q3ULZ2-1","NP_001028473.2","FH2 domain-containing protein 1","1149",""
> "Q8BGQ1-1","NP_001136052.1","spermatogenesis-defective protein 39 homolog isoform a","491",""
7599,7600d7589
< "Q8C726-1","NP_766206.1","BTB/POZ domain-containing protein 9","612",""
< "Q8BGS1-1","NP_663481.2","band 4.1-like protein 5 isoform 1","731",""
7602a7592
> "Q9QXS1-1","NP_001157012.1","plectin isoform 12alpha","4691","Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as 'hemidesmosomal protein 1' or 'plectin 1, intermediate filament binding 500kDa'. These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). It has been shown that the short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (human variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. [provided by RefSeq, Aug 2011]. "
7605d7594
< "Q9ESL4-1","NP_835185.2","mitogen-activated protein kinase kinase kinase 20 isoform 2","289",""
7607a7597
> "Q9D8U8-1","NP_001186117.1","sorting nexin-5","404",""
7609,7610c7599
< "Q5PT53-1","NP_084012.1","sodium/bile acid cotransporter 7 isoform a","340",""
< "P97391-1","NP_035240.3","calcium-dependent phospholipase A2 precursor","137",""
---
> "Q8K3J1-1","NP_001258372.1","NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial","212",""
7612a7602,7605
> "Q3LRV9-1","NP_001029094.1","trem-like transcript 4 protein isoform 1 precursor","259",""
> "Q5DQR4-1","NP_001108083.1","syntaxin-binding protein 5-like isoform s","1104",""
> "Q9EP71-1","NP_001159880.1","ankycorbin isoform 1","979",""
> "P63242-1","NP_001160061.1","eukaryotic translation initiation factor 5A-1","154","This gene encodes an elongation initiation factor, which participates in protein synthesis. The encoded protein also plays roles in mRNA metabolism, cell proliferation, and cell cycle control. This protein contains a modified lysine residue called hypusine, which appears to be necessary for its function. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2, 5, and 19. [provided by RefSeq, Oct 2009]. "
7614,7615c7607,7608
< "Q9D8U8-1","NP_077187.1","sorting nexin-5","404",""
< "Q91X78-1","NP_663477.3","erlin-1","348",""
---
> "Q8C8U0-1","NP_001163904.1","liprin-beta-1 isoform 1","980",""
> "Q8BGS1-1","NP_001106887.1","band 4.1-like protein 5 isoform 2","504",""
7619d7611
< "Q6ZPK0-10","NP_620094.2","PHD finger protein 21A isoform 1","556",""
7621c7613
< "Q8BIE6-1","NP_766063.3","FERM domain-containing protein 4A isoform 1","1042",""
---
> "Q8K4G1-1","NP_001107021.1","latent-transforming growth factor beta-binding protein 4 isoform b precursor","1600",""
7622a7615
> "Q5SUQ9-1","NP_001013274.2","CST complex subunit CTC1 isoform a","1212",""
7625a7619
> "Q9CY27-1","NP_081455.1","very-long-chain enoyl-CoA reductase isoform 2","293",""
7627,7630d7620
< "Q5DQR4-1","NP_766028.2","syntaxin-binding protein 5-like isoform xb","1185",""
< "Q9D0F3-1","NP_081676.1","protein ERGIC-53 precursor","517",""
< "Q8BGQ1-1","NP_598805.2","spermatogenesis-defective protein 39 homolog isoform b","472",""
< "Q99J47-1","NP_663403.1","dehydrogenase/reductase SDR family member 7B isoform 2","323",""
7632a7623
> "Q8BXB6-1","NP_001239459.1","solute carrier organic anion transporter family member 2B1 isoform 1","693",""
7633a7625,7627
> "Q8CI71-1","NP_001161222.1","syndetin isoform 2","929",""
> "Q9WV76-1","NP_001157024.1","AP-4 complex subunit beta-1 isoform a","738",""
> "Q3UMY5-1","NP_001107834.1","echinoderm microtubule-associated protein-like 4 isoform 2","919",""
7636d7629
< "Q8BFY9-1","NP_848831.2","transportin-1 isoform 1","898",""
7638a7632
> "Q6P2L7-1","NP_001192298.1","protein CASC4 isoform 3","435",""
7640,7641d7633
< "Q9JL26-1","NP_062653.2","formin-like protein 1 isoform 1","1090",""
< "P14576-1","NP_036029.2","signal recognition particle 54 kDa protein","504",""
7645c7637,7638
< "Q3TWN3-1","NP_291047.2","metal transporter CNNM2 isoform a","875",""
---
> "Q3TWN3-1","NP_001095941.1","metal transporter CNNM2 isoform b","853",""
> "Q91YH5-1","NP_001156977.1","atlastin-3 isoform 1","536",""
7648a7642
> "P97391-1","NP_001116426.1","calcium-dependent phospholipase A2 precursor","137",""
7651d7644
< "P32067-1","NP_033304.1","lupus La protein homolog isoform a","415",""
7654d7646
< "Q8K3J1-1","NP_659119.2","NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial","212",""
7658d7649
< "Q8BXB6-1","NP_780525.1","solute carrier organic anion transporter family member 2B1 isoform 2","683",""
7659a7651
> "Q7TSJ2-1","NP_001036820.2","microtubule-associated protein 6 isoform 3","306",""
7662d7653
< "Q9Z261-1","NP_058583.1","claudin-7 precursor","211","This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed constitutively in the mammary epithelium throughout development, and might be involved in vesicle trafficking to the basolateral membrane. It is essential for NaCl homeostasis in distal nephrons. The knockout mice lacking this gene showed severe salt wasting, chronic dehydration, and growth retardation, and died within 12 days after birth. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]. "
7665c7656
< "Q3ULZ2-1","NP_001192284.1","FH2 domain-containing protein 1","1149",""
---
> "Q80TZ3-1","NP_001158055.1","putative tyrosine-protein phosphatase auxilin isoform a","968",""
7667c7658
< "Q8VDK3-1","NP_034255.2","ETS-related transcription factor Elf-5","253",""
---
> "Q9ESL4-1","NP_001158263.1","mitogen-activated protein kinase kinase kinase 20 isoform 3","454",""
7670,7671c7661
< "Q9QYX7-1","NP_036125.4","protein piccolo isoform 1","5068",""
< "Q64008-1","NP_258436.2","ras-related protein Rab-34","259",""
---
> "Q5DTL9-1","NP_001229309.1","sodium-driven chloride bicarbonate exchanger isoform 4","1118",""
7675c7665
< "P63242-1","NP_853613.1","eukaryotic translation initiation factor 5A-1","154","This gene encodes an elongation initiation factor, which participates in protein synthesis. The encoded protein also plays roles in mRNA metabolism, cell proliferation, and cell cycle control. This protein contains a modified lysine residue called hypusine, which appears to be necessary for its function. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2, 5, and 19. [provided by RefSeq, Oct 2009]. "
---
> "Q9DBR3-1","NP_001159610.1","armadillo repeat-containing protein 8 isoform 2","399",""
7676a7667,7668
> "Q8R054-1","NP_001077364.2","sushi repeat-containing protein SRPX2 precursor","468",""
> "Q91X78-1","NP_001157831.1","erlin-1","348",""
7679,7680c7671,7673
< "P49446-1","NP_035342.3","receptor-type tyrosine-protein phosphatase epsilon isoform b precursor","699",""
< "Q5DTL9-1","NP_001229312.1","sodium-driven chloride bicarbonate exchanger isoform 7","1105",""
---
> "Q64008-1","NP_001152954.1","ras-related protein Rab-34","259",""
> "Q9QZV9-1","NP_001103629.1","NTF2-related export protein 1","140",""
> "O88576-1","NP_001035782.1","sodium-dependent neutral amino acid transporter B(0)AT3 isoform 1","615",""
7683,7684d7675
< "Q9EP71-1","NP_109615.1","ankycorbin isoform 1","979",""
< "Q6P2L7-1","NP_950239.2","protein CASC4 isoform 2","346",""
7685a7677
> "Q8BXL7-1","NP_001159463.1","ADP-ribosylation factor-related protein 1 isoform 1","201","The gene encodes a membrane-associated GTPase that is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. It plays an essential role in Golgi function controlling recruitment of GRIP domain proteins and ARL1 to the trans-Golgi and trans-Golgi to plasma membrane trafficking of cell surface proteins such as E-cadherin. Deletion of this gene in mice leads to embryonic lethality during early gastrulation, which is at least partly caused by the disruption of E-cadherin trafficking to the cell surface and therefore lack of sufficient cell-cell adhesion in the embryo. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]. "
7688a7681
> "Q9CQC4-1","NP_001264789.1","transmembrane protein 216 isoform 1","141","This gene encodes a transmembrane protein which is involved in regulation of signaling and trafficking of associated proteins. In humans, mutations in this gene are associated with ciliopathies including Joubert, Meckel and related syndromes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]. "
7691d7683
< "Q4LDD4-1","NP_932764.1","arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform 2","727",""
7695d7686
< "Q8BXL7-1","NP_083978.3","ADP-ribosylation factor-related protein 1 isoform 1","201","The gene encodes a membrane-associated GTPase that is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. It plays an essential role in Golgi function controlling recruitment of GRIP domain proteins and ARL1 to the trans-Golgi and trans-Golgi to plasma membrane trafficking of cell surface proteins such as E-cadherin. Deletion of this gene in mice leads to embryonic lethality during early gastrulation, which is at least partly caused by the disruption of E-cadherin trafficking to the cell surface and therefore lack of sufficient cell-cell adhesion in the embryo. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]. "
7702a7694
> "Q8BND3-1","NP_001152999.1","WD repeat-containing protein 35 isoform 2","1170",""
7708d7699
< "Q5FWH2-3","NP_083065.1","putative E3 ubiquitin-protein ligase UNKL isoform 2","239",""
7710,7711c7701
< "Q9JLJ5-1","NP_062295.1","elongation of very long chain fatty acids protein 1 isoform 1","279",""
< "Q62189-1","NP_056597.3","U1 small nuclear ribonucleoprotein A","287",""
---
> "Q9D0F3-1","NP_001165533.1","protein ERGIC-53 precursor","517",""
7714c7704
< "Q8R001-1","NP_694698.3","microtubule-associated protein RP/EB family member 2 isoform 1","326",""
---
> "Q8R3Y5-1","NP_001116239.1","uncharacterized protein C19orf47 homolog isoform 2","371",""
7716d7705
< "Q80YT7-1","NP_835181.2","myomegalin isoform 2","1118",""
7717a7707
> "Q5PT53-1","NP_001009981.1","sodium/bile acid cotransporter 7 isoform c","312",""
7720,7721c7710
< "Q9QYR7-1","NP_599007.1","acyl-coenzyme A thioesterase 3 isoform 1","432",""
< "P70347-1","NP_035659.1","TRAF family member-associated NF-kappa-B activator isoform 3","448",""
---
> "Q8BIE6-1","NP_001171314.1","FERM domain-containing protein 4A isoform 2","1020",""
7724a7714
> "Q80YT7-1","NP_001034465.2","myomegalin isoform 1","2446",""
7726,7727c7716
< "Q3UMY5-1","NP_955760.3","echinoderm microtubule-associated protein-like 4 isoform 3","876",""
< "Q91YH5-1","NP_666203.3","atlastin-3 isoform 2","541",""
---
> "Q9JLJ5-1","NP_001034264.1","elongation of very long chain fatty acids protein 1 isoform 2","202",""
7736a7726
> "P59325-1","NP_775539.1","eukaryotic translation initiation factor 5","429",""
7738a7729
> "Q9Z261-1","NP_001180548.1","claudin-7 precursor","211","This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed constitutively in the mammary epithelium throughout development, and might be involved in vesicle trafficking to the basolateral membrane. It is essential for NaCl homeostasis in distal nephrons. The knockout mice lacking this gene showed severe salt wasting, chronic dehydration, and growth retardation, and died within 12 days after birth. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]. "
7740d7730
< "P40336-1","NP_598433.1","vacuolar protein sorting-associated protein 26A isoform a","327",""
7745c7735
< "Q8R054-1","NP_081114.2","sushi repeat-containing protein SRPX2 precursor","468",""
---
> "Q62189-1","NP_001040102.1","U1 small nuclear ribonucleoprotein A","287",""
7751,7752d7740
< "Q9QZV9-1","NP_062735.4","NTF2-related export protein 1","140",""
< "Q5SUQ9-1","NP_001268394.1","CST complex subunit CTC1 isoform b","966",""
7755a7744
> "Q8R001-1","NP_001156413.1","microtubule-associated protein RP/EB family member 2 isoform 2","317",""
7758d7746
< "Q8CI71-1","NP_077222.4","syndetin isoform 1","964",""
7760c7748
< "Q62172-1","NP_033093.2","ralA-binding protein 1","648",""
---
> "Q5FWH2-3","NP_001183953.1","putative E3 ubiquitin-protein ligase UNKL isoform 1","727",""
7765d7752
< "Q5SW75-1","NP_808378.2","protein phosphatase Slingshot homolog 2 isoform 1","1423",""
7766a7754,7755
> "Q91VU7-1","NP_001276709.1","pseudouridylate synthase 7 homolog isoform 1","666",""
> "Q09324-1","NP_001129956.3","beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase","428",""
7771,7772c7760,7761
< "Q6ZPF4-1","NP_035841.1","formin-like protein 3 isoform 1","1028",""
< "Q6Y7W8-1","NP_666224.3","GRB10-interacting GYF protein 2 isoform a","1291",""
---
> "Q8BVE3-1","NP_001297371.1","V-type proton ATPase subunit H isoform 2","465",""
> "Q9QYR7-1","NP_001333630.1","acyl-coenzyme A thioesterase 3 isoform 2","421",""
7776c7765,7766
< "Q7TNG5-1","NP_082429.1","echinoderm microtubule-associated protein-like 2 isoform 1","668",""
---
> "B2RQC6-1","NP_001276451.1","CAD protein isoform 2","2154",""
> "Q0VGM9-1","NP_001001882.3","regulator of telomere elongation helicase 1 isoform 1","1209",""
7781,7782d7770
< "Q8BKC8-1","NP_780565.2","phosphatidylinositol 4-kinase beta isoform 2","801",""
< "Q9EPU4-1","NP_444423.1","cleavage and polyadenylation specificity factor subunit 1 isoform 2","1441",""
7784,7785c7772
< "Q80WT5-1","NP_852076.1","aftiphilin isoform 1","904",""
< "Q8QZY6-1","NP_666040.1","tetraspanin-14","270",""
---
> "Q0P5X5-1","NP_001297458.1","zinc finger B-box domain-containing protein 1 isoform 2","711",""
7786a7774
> "Q9CPU9-1","NP_001277447.1","probable low affinity copper uptake protein 2 isoform 2","141",""
7788,7789d7775
< "Q8BVE3-1","NP_598587.2","V-type proton ATPase subunit H isoform 1","483",""
< "Q0P5X5-1","NP_766103.2","zinc finger B-box domain-containing protein 1 isoform 1","716",""
7792,7794c7778
< "Q6P2B1-1","NP_796270.2","transportin-3 isoform 1","923",""
< "Q0VGM9-1","NP_001160140.1","regulator of telomere elongation helicase 1 isoform 5","1128",""
< "Q3TX08-1","NP_932137.2","tRNA (guanine(26)-N(2))-dimethyltransferase isoform 1","663",""
---
> "Q9QYX7-1","NP_001104266.1","protein piccolo isoform 2","4863",""
7797a7782
> "A6H684-1","NP_001138772.1","alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E isoform 1","439",""
7799d7783
< "Q91VU7-1","NP_848490.2","pseudouridylate synthase 7 homolog isoform 2","660",""
7803d7786
< "Q9CPU9-1","NP_079562.1","probable low affinity copper uptake protein 2 isoform 1","143",""
7806c7789
< "Q09324-1","NP_775618.3","beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase","428",""
---
> "P56384-1","NP_001288650.1","ATP synthase F(0) complex subunit C3, mitochondrial isoform a precursor","141","The protein encoded by this gene is a subunit of mitochondrial membrane ATP synthase, the enzyme that catalyzes ATP synthesis during oxidative phosphorylation. This gene encodes subunit 9, which is present in multiple copies in the transmembrane part of the ATP synthase complex. Phenotype and gene expression profiles suggest correlations between this gene and alcoholism- and obesity-related phenotypes. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Sep 2014]. "
7808a7792
> "Q9Z1G4-1","NP_001229979.1","V-type proton ATPase 116 kDa subunit a isoform 1 isoform 3","832",""
7809a7794
> "Q64152-1","NP_001164011.1","transcription factor BTF3 isoform 2","162",""
7812a7798,7799
> "Q8BGR5-1","NP_001334559.1","protein FAM53B isoform b","392",""
> "Q8R3V5-4","NP_001276638.1","endophilin-B2 isoform 1","400",""
7815d7801
< "A6H684-1","NP_001277944.1","alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E isoform 2","357",""
7819c7805
< "Q9CX30-1","NP_084163.2","protein YIF1B isoform 1","311",""
---
> "Q6ZPF4-1","NP_001297551.1","formin-like protein 3 isoform 2","1027",""
7824c7810,7811
< "Q60854-1","NP_033280.1","serpin B6 isoform b","378",""
---
> "Q8BKC8-1","NP_001280644.1","phosphatidylinositol 4-kinase beta isoform 1","816",""
> "Q60854-1","NP_001157590.1","serpin B6 isoform b","378",""
7826c7813
< "Q9DCG2-1","NP_079698.2","CD302 antigen isoform b precursor","219",""
---
> "Q9DCG2-1","NP_001277589.1","CD302 antigen isoform a precursor","228",""
7828c7815
< "P56384-1","NP_778180.1","ATP synthase F(0) complex subunit C3, mitochondrial isoform a precursor","141","The protein encoded by this gene is a subunit of mitochondrial membrane ATP synthase, the enzyme that catalyzes ATP synthesis during oxidative phosphorylation. This gene encodes subunit 9, which is present in multiple copies in the transmembrane part of the ATP synthase complex. Phenotype and gene expression profiles suggest correlations between this gene and alcoholism- and obesity-related phenotypes. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Sep 2014]. "
---
> "P05064-1","NP_001170779.1","fructose-bisphosphate aldolase A isoform 2","364",""
7830a7818
> "Q6P2B1-1","NP_001334008.1","transportin-3 isoform 2","929",""
7836c7824
< "Q9QZ85-1","NP_068564.4","interferon-inducible GTPase 1","413",""
---
> "Q7TNG5-1","NP_001156468.1","echinoderm microtubule-associated protein-like 2 isoform 2","649",""
7838a7827,7828
> "Q8BMY7-1","NP_001276697.1","serine protease inhibitor Kazal-type 2 isoform 4 precursor","56",""
> "Q3TX08-1","NP_001158031.1","tRNA (guanine(26)-N(2))-dimethyltransferase isoform 1","663",""
7843c7833
< "Q8R3V5-4","NP_647463.1","endophilin-B2 isoform 2","395",""
---
> "Q9CX30-1","NP_001103671.1","protein YIF1B isoform 2","308",""
7846a7837
> "Q5SW75-1","NP_001278119.1","protein phosphatase Slingshot homolog 2 isoform 2","1429",""
7848a7840
> "P49446-1","NP_001303607.1","receptor-type tyrosine-protein phosphatase epsilon isoform a","719",""
7849a7842
> "Q6Y7W8-1","NP_001103682.1","GRB10-interacting GYF protein 2 isoform b","1285",""
7851c7844
< "B2RQC6-1","NP_076014.1","CAD protein isoform 1","2225",""
---
> "Q80WT5-1","NP_001239432.1","aftiphilin isoform 2","822",""
7854d7846
< "Q64152-1","NP_663430.2","transcription factor BTF3 isoform 1","204",""
7858a7851,7853
> "Q8QZY6-1","NP_001303677.1","tetraspanin-14","270",""
> "Q80YA9-1","NP_001297648.1","connector enhancer of kinase suppressor of ras 2 isoform 2","983",""
> "Q8BK06-1","NP_001074959.1","F-box only protein 9 isoform 2","437",""
7860d7854
< "Q8BGR5-1","NP_997638.1","protein FAM53B isoform a","422",""
7862d7855
< "P05064-1","NP_031464.1","fructose-bisphosphate aldolase A isoform 2","364",""
7863a7857
> "Q0VG62-2","NP_001093144.1","ribosomal biogenesis factor isoform 2","97",""
7877c7871
< "Q0VG62-2","NP_001334135.1","ribosomal biogenesis factor isoform 1 precursor","139",""
---
> "Q3TT38-1","NP_001028451.2","protein ILRUN isoform 1","291",""
7891d7884
< "Q8R5H1-1","NP_081880.2","ubiquitin carboxyl-terminal hydrolase 15 isoform 1","981","The protein encoded by this gene is a member of the large ubiquitin specific protease (Usp) family of proteins. These proteins are known to cleave ubiquitin, and contain a conserved cysteine residue (Cys box) and two conserved histidine residues (His box) that are thought to form part of the active site of the protease. This protein has been shown to cleave both the ubiquitin-proline and the ubiquitin-methionine bonds in vitro. This protein is thought to regulate many cellular processes through its deubiquitination activity, including the transforming growth factor beta (TGF-beta) pathway. Cardiac-specific overexpression of the human ortholog of this gene in mice causes enlargement of the heart that is more pronounced in the atrium than in the ventricle. This gene has two pseudogenes on chromosome 14. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms.[provided by RefSeq, Aug 2014]. "
7896,7898c7889,7892
< "Q9QXV3-1","NP_036049.2","inhibitor of growth protein 1 isoform 1","279",""
< "Q8C7R7-1","NP_796280.1","DNA-binding protein RFX6 isoform 2","663",""
< "Q8K0U4-1","NP_780408.1","heat shock 70 kDa protein 12A isoform 2","675",""
---
> "Q5SQX6-1","NP_001239388.1","cytoplasmic FMR1-interacting protein 2","1253",""
> "Q01231-1","NP_001258557.1","gap junction alpha-5 protein","358",""
> "Q5U4H9-1","NP_001029160.1","nuclear receptor coactivator 4 isoform a","625",""
> "Q8C7R7-1","NP_001152861.1","DNA-binding protein RFX6 isoform 1","927",""
7900,7902c7894
< "Q5SQX6-1","NP_598530.2","cytoplasmic FMR1-interacting protein 2","1253",""
< "Q5U4H9-1","NP_062718.2","nuclear receptor coactivator 4 isoform a","625",""
< "Q01231-1","NP_032147.1","gap junction alpha-5 protein","358",""
---
> "Q8K0U4-1","NP_001314927.1","heat shock 70 kDa protein 12A isoform 1","693",""
7904a7897
> "Q9QXV3-1","NP_001289386.1","inhibitor of growth protein 1 isoform 3","185",""
7908,7909c7901,7902
< "A2AJB9-1","NP_808508.2","epididymal-specific lipocalin-6 isoform 2 precursor","181",""
< "A2AJB7-1","NP_031973.2","epididymal-specific lipocalin-5 isoform a precursor","192","This gene encodes a small secreted protein that is expressed in the epididymis and binds retinoic acid. The precursor protein is processed into both a longer major form and a shorter minor form. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]. "
---
> "A2AJB9-1","NP_001263377.1","epididymal-specific lipocalin-6 isoform 1 precursor","245",""
> "A2AJB7-1","NP_001036095.1","epididymal-specific lipocalin-5 isoform b precursor","180","This gene encodes a small secreted protein that is expressed in the epididymis and binds retinoic acid. The precursor protein is processed into both a longer major form and a shorter minor form. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]. "
7914c7907
< "Q6HA09-1","NP_766127.1","astacin-like metalloendopeptidase isoform b","414",""
---
> "Q6HA09-1","NP_001277932.1","astacin-like metalloendopeptidase isoform a precursor","435",""
7917d7909
< "G5E8A8-1","NP_001277930.1","tektin-5","557",""
7922d7913
< "Q811P8-1","NP_796353.3","rho GTPase-activating protein 32 isoform 2","1740",""
7924a7916
> "Q811P8-1","NP_001182561.1","rho GTPase-activating protein 32 isoform 1","2089",""
7926c7918
< "Q8R2K1-1","NP_081204.2","fucose mutarotase isoform 1","153",""
---
> "Q8R2K1-1","NP_001273146.1","fucose mutarotase isoform 2","161",""
7946a7939
> "Q91WG1-1","NP_001258460.1","insulin-induced gene 2 protein isoform 1","225",""
7949d7941
< "Q91WG1-1","NP_835183.1","insulin-induced gene 2 protein isoform 1","225",""
7952d7943
< "Q9R0L1-1","NP_036069.1","heat shock factor protein 4 isoform 2","462",""
7959,7961c7950,7951
< "Q5NBU8-1","NP_001278082.1","XIAP-associated factor 1 isoform 2","178",""
< "Q9CR67-1","NP_084384.1","transmembrane protein 33 isoform 2","246",""
< "B1AZP2-1","NP_666240.4","disks large-associated protein 4 isoform a","992","This gene encodes a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. The encoded protein may play a role in synapse organization and neuronal signalling. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Mar 2013]. "
---
> "Q9R0L1-1","NP_001242971.1","heat shock factor protein 4 isoform 1","492",""
> "P39054-1","NP_001240822.1","dynamin-2 isoform 1","870",""
7968c7958
< "Q5QNS5-1","NP_599009.2","hepatitis A virus cellular receptor 1 homolog isoform a precursor","305",""
---
> "B1AZP2-1","NP_001035952.1","disks large-associated protein 4 isoform b","453","This gene encodes a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. The encoded protein may play a role in synapse organization and neuronal signalling. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Mar 2013]. "
7970d7959
< "Q99MK9-1","NP_062687.1","ras association domain-containing protein 1 isoform 2","270",""
7975a7965
> "Q5NBU8-1","NP_001032802.2","XIAP-associated factor 1 isoform 1","273",""
7980d7969
< "P39054-1","NP_031897.2","dynamin-2 isoform 3","866",""
7981a7971,7972
> "Q5QNS5-1","NP_001160103.1","hepatitis A virus cellular receptor 1 homolog isoform b precursor","282",""
> "Q99MK9-1","NP_001230677.1","ras association domain-containing protein 1 isoform 1","340",""
7983a7975
> "Q9CR67-1","NP_001272381.1","transmembrane protein 33 isoform 1","247",""
7985,7986c7977,7978
< "Q7TQ48-1","NP_780556.2","sarcalumenin isoform 1 precursor","910",""
< "A2AP18-1","NP_780765.2","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform a","1238",""
---
> "Q7TQ48-1","NP_001334091.1","sarcalumenin isoform 2 precursor","472",""
> "A2AP18-1","NP_001106831.1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform b","1501",""
7990d7981
< "Q3V209-1","NP_082352.1","transmembrane and ubiquitin-like domain-containing protein 2 isoform 1","319","This gene encodes a predicted multi-pass membrane protein that features a C-terminal ubiquitin-related domain. This gene may be expressed in cone photoreceptors in the retina. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. "
7992c7983
< "A4Q9E5-1","NP_598684.4","tubulin monoglycylase TTLL3 isoform 1","927",""
---
> "Q3V209-1","NP_001289434.1","transmembrane and ubiquitin-like domain-containing protein 2 isoform 1","319","This gene encodes a predicted multi-pass membrane protein that features a C-terminal ubiquitin-related domain. This gene may be expressed in cone photoreceptors in the retina. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. "
8001c7992,7993
< "Q8VI23-1","NP_599012.2","solute carrier family 12 member 8 isoform 1","705",""
---
> "Q2EG98-1","NP_001034789.2","polycystic kidney disease protein 1-like 3 isoform a precursor","2201",""
> "Q8VI23-1","NP_001077371.1","solute carrier family 12 member 8 isoform 2","625",""
8005d7996
< "Q8BMY7-1","NP_899107.1","serine protease inhibitor Kazal-type 2 isoform 2 precursor","86",""
8010a8002
> "Q4KWH5-1","NP_001171203.1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 3","1003",""
8013d8004
< "Q4KWH5-1","NP_899014.2","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 1","1682",""
8039,8040c8030,8031
< "Q8R1G6-1","NP_666090.1","PDZ and LIM domain protein 2","349",""
< "Q3UUG6-1","NP_775278.3","TBC1 domain family member 24 isoform b","555",""
---
> "Q3UUG6-1","NP_001157319.1","TBC1 domain family member 24 isoform a","561",""
> "Q8R1G6-1","NP_001240665.1","PDZ and LIM domain protein 2","349",""
8042a8034
> "Q8CHD8-1","NP_001156340.1","rab11 family-interacting protein 3 isoform b","1047",""
8046d8037
< "Q8CHD8-1","NP_694780.1","rab11 family-interacting protein 3 isoform c","444",""
8052c8043
< "Q8C7Q4-1","NP_033058.2","RNA-binding protein 4 isoform a","361",""
---
> "Q8C7Q4-1","NP_001277051.1","RNA-binding protein 4 isoform a","361",""
8065,8066c8056,8057
< "Q60682-1","NP_034780.1","killer cell lectin-like receptor 8 isoform 2","263",""
< "P58735-1","NP_777359.3","sulfate anion transporter 1 isoform 2","704",""
---
> "P58735-1","NP_001297621.1","sulfate anion transporter 1 isoform 2","704",""
> "Q60682-1","NP_001095090.1","killer cell lectin-like receptor 8 isoform 1","266",""
8069d8059
< "Q925P2-1","NP_031569.1","carcinoembryonic antigen-related cell adhesion molecule 2 isoform c precursor","272",""
8072d8061
< "Q76LL6-1","NP_780485.2","FH1/FH2 domain-containing protein 3 isoform 1","1578",""
8076c8065
< "Q9EST8-1","NP_085115.1","NF-kappa-B inhibitor zeta isoform a","728",""
---
> "Q9EST8-1","NP_001152866.1","NF-kappa-B inhibitor zeta isoform a","728",""
8081c8070
< "Q6NZH9-1","NP_997129.1","ras guanyl-releasing protein 3","691",""
---
> "O88623-1","NP_058088.2","ubiquitin carboxyl-terminal hydrolase 2 isoform Usp2-69","619",""
8083,8084c8072,8073
< "Q9Z204-1","NP_058580.1","heterogeneous nuclear ribonucleoproteins C1/C2 isoform 1","313",""
< "Q9QZH6-1","NP_036159.1","evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor","435",""
---
> "Q9QZH6-1","NP_001240826.1","evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor","435",""
> "Q6NZH9-1","NP_001159965.1","ras guanyl-releasing protein 3","691",""
8086,8087c8075,8076
< "Q9JL60-1","NP_064669.2","glucocorticoid modulatory element-binding protein 1","562",""
< "Q80Y17-1","NP_032528.1","lethal(2) giant larvae protein homolog 1 isoform 2","1034",""
---
> "Q61990-1","NP_001096635.1","poly(rC)-binding protein 2 isoform 1","362",""
> "Q80Y17-1","NP_001152876.1","lethal(2) giant larvae protein homolog 1 isoform 3","1036",""
8089,8090c8078
< "O88623-1","NP_932760.2","ubiquitin carboxyl-terminal hydrolase 2 isoform Usp2-69","619",""
< "Q61990-1","NP_035172.2","poly(rC)-binding protein 2 isoform 2","349",""
---
> "Q9JL60-1","NP_001116464.1","glucocorticoid modulatory element-binding protein 1","562",""
8092d8079
< "Q9WVS8-1","NP_035971.1","mitogen-activated protein kinase 7 isoform a","806",""
8094,8096c8081,8083
< "Q9WVJ5-1","NP_076184.1","beta-crystallin B1","250","This gene encodes a member of the crystallin family of proteins that contribute to the transparency and refractive properties of the ocular lens. The encoded protein associates with other beta crystallin proteins to form dimers, tetramers and other higher-order complexes. This gene is located adjacent to a related crystallin gene on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. "
< "Q8BJQ9-1","NP_766341.4","chondroitin sulfate N-acetylgalactosaminyltransferase 1","530",""
< "O54826-1","NP_034934.2","protein AF-10 isoform 1","1068",""
---
> "Q8BJQ9-1","NP_001239552.1","chondroitin sulfate N-acetylgalactosaminyltransferase 1","530",""
> "Q9WVJ5-1","NP_001299822.1","beta-crystallin B1","250","This gene encodes a member of the crystallin family of proteins that contribute to the transparency and refractive properties of the ocular lens. The encoded protein associates with other beta crystallin proteins to form dimers, tetramers and other higher-order complexes. This gene is located adjacent to a related crystallin gene on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. "
> "O54826-1","NP_001239489.1","protein AF-10 isoform 1","1068",""
8098a8086
> "Q9WVS8-1","NP_001277962.1","mitogen-activated protein kinase 7 isoform b","737",""
8101d8088
< "Q9WUU8-1","NP_001258384.1","TNFAIP3-interacting protein 1 isoform 2","594",""
8103c8090,8091
< "O89084-1","NP_899668.1","cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 5","844",""
---
> "O55242-1","NP_001273467.1","sigma non-opioid intracellular receptor 1 isoform 2","218","This gene encodes a transmembrane protein located in the endoplasmic reticulum. The encoded protein is a receptor that binds several endogenous ligands, including N,N-dimethyltryptamine, progesterone and pregnenolone and a variety of of non-opiate compounds. The encoded protein plays a role in regulating the activity of ion channels, acting as a chaperone and protecting cells from oxidative stress. In humans, this receptor has been associated with Alzheimer's and Parkinson's diseases, stroke and numerous disease conditions such as depression, pain and addiction. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2013]. "
> "Q9Z2I8-1","NP_001313487.1","succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 2","384",""
8106a8095
> "Q62448-1","NP_001035221.1","eukaryotic translation initiation factor 4 gamma 2 isoform 2","868","Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G, that contains the binding sites for eIF4A and eIF3; eIF4G in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. Transgene expression of the apolipoprotein B mRNA-editing enzyme (APOBEC-1) causes extensive editing of this mRNA, which could contribute to the potent oncogenesis induced by overexpression of APOBEC-1. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse. Two alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. "
8109,8110d8097
< "O55242-1","NP_035144.1","sigma non-opioid intracellular receptor 1 isoform 1","223","This gene encodes a transmembrane protein located in the endoplasmic reticulum. The encoded protein is a receptor that binds several endogenous ligands, including N,N-dimethyltryptamine, progesterone and pregnenolone and a variety of of non-opiate compounds. The encoded protein plays a role in regulating the activity of ion channels, acting as a chaperone and protecting cells from oxidative stress. In humans, this receptor has been associated with Alzheimer's and Parkinson's diseases, stroke and numerous disease conditions such as depression, pain and addiction. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2013]. "
< "Q62447-1","NP_058026.2","cyclin-C isoform 1","283",""
8113a8101
> "Q9Z210-1","NP_001155859.1","peroxisomal membrane protein 11B isoform 1","259",""
8119,8120d8106
< "P62996-1","NP_033212.1","transformer-2 protein homolog beta isoform 1","288",""
< "Q9Z2I8-1","NP_035637.2","succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 1 precursor","433",""
8124d8109
< "Q9D0P7-1","NP_064360.1","proline/serine-rich coiled-coil protein 1","329",""
8125a8111
> "P62996-1","NP_001317483.1","transformer-2 protein homolog beta isoform 2","287",""
8132d8117
< "Q9Z210-1","NP_035199.3","peroxisomal membrane protein 11B isoform 1","259",""
8133a8119,8121
> "O89084-1","NP_062772.3","cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 1","610",""
> "Q9EPK2-1","NP_001277572.1","protein XRP2 isoform a","347",""
> "Q9WUU8-1","NP_001186205.1","TNFAIP3-interacting protein 1 isoform 2","594",""
8135a8124
> "Q9D0P7-1","NP_001177090.1","proline/serine-rich coiled-coil protein 1","329",""
8138a8128
> "Q9CS84-1","NP_001333891.1","neurexin-1 isoform 8","139","This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. Alternative splicing and promoter usage result in multiple transcript variants. [provided by RefSeq, Nov 2016]. "
8142d8131
< "Q62448-1","NP_038535.2","eukaryotic translation initiation factor 4 gamma 2 isoform 1","906","Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G, that contains the binding sites for eIF4A and eIF3; eIF4G in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. Transgene expression of the apolipoprotein B mRNA-editing enzyme (APOBEC-1) causes extensive editing of this mRNA, which could contribute to the potent oncogenesis induced by overexpression of APOBEC-1. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse. Two alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. "
8144d8132
< "P38532-1","NP_032322.1","heat shock factor protein 1 isoform beta","503",""
8145a8134
> "Q9QXD1-1","NP_001155139.1","peroxisomal acyl-coenzyme A oxidase 2","681",""
8146a8136,8137
> "Q7TSA3-1","NP_001032808.2","B- and T-lymphocyte attenuator isoform 1 precursor","306",""
> "O54804-1","NP_001258425.1","choline kinase alpha isoform 3","453",""
8149,8150c8140
< "Q05685-1","NP_032061.1","folate receptor beta precursor","251","This gene encodes a receptor protein located on the plasma membrane that mediates folate uptake by cells. Mice lacking the product of this gene show no defects in embryonic development and grow normally into fertile adults. However, such mice were found to be highly susceptible to the teratogenic effects of arsenic. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]. "
< "Q8BRH0-1","NP_001103483.1","protein O-mannosyl-transferase TMTC3 isoform 1","920",""
---
> "P70704-1","NP_001034088.1","phospholipid-transporting ATPase IA isoform a","1164",""
8153a8144,8145
> "Q8C7X2-1","NP_001034289.1","ER membrane protein complex subunit 1 isoform 2 precursor","994",""
> "Q6ZWY8-1","NP_001034481.1","thymosin beta-10","44",""
8157c8149,8150
< "Q8K135-1","NP_598647.1","dyslexia-associated protein KIAA0319-like protein isoform 2","1048",""
---
> "Q2Q5T5-1","NP_001170939.1","protein myomixer isoform 1","84",""
> "Q8BRH0-1","NP_001028504.1","protein O-mannosyl-transferase TMTC3 isoform 2","658",""
8159a8153
> "Q8CI51-1","NP_001177781.1","PDZ and LIM domain protein 5 isoform ENH1e","614",""
8161d8154
< "Q8C7X2-1","NP_666269.2","ER membrane protein complex subunit 1 isoform 1 precursor","997",""
8163c8156
< "Q925H0-1","NP_031410.1","acid-sensing ion channel 2 isoform MDEG2","563",""
---
> "Q925H0-1","NP_001029185.1","acid-sensing ion channel 2 isoform MDEG1","512",""
8167d8159
< "Q8C167-1","NP_666096.3","prolyl endopeptidase-like isoform b","638",""
8170,8171c8162
< "Q2Q5T5-1","NP_001170941.1","protein myomixer isoform 2","108",""
< "Q7TQA1-1","NP_899179.1","immunoglobulin superfamily member 1 isoform 4 precursor","775",""
---
> "Q63ZW7-1","NP_001005784.1","inaD-like protein isoform 2","975","This gene encodes a multivalent PDZ domain protein, which is expressed exclusively in brain and kidney. This protein selectively interacts with inward rectifier K+ (Kir) family members, N-methyl-D-aspartate receptor subunits, neurexins and neuroligins, as well as cell surface molecules enriched in synaptic membranes. Thus, this protein may serve as a scaffold that brings structurally diverse but functionally connected proteins into close proximity at the synapse. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. "
8174c8165,8166
< "Q4FJU9-1","NP_659054.2","transmembrane protein 40 isoform a","225",""
---
> "Q80XR2-1","NP_001240760.1","calcium-transporting ATPase type 2C member 1 isoform 1","952",""
> "Q03141-1","NP_067491.2","MAP/microtubule affinity-regulating kinase 3 isoform 1","744",""
8175a8168,8169
> "Q8K4N2-1","NP_001034652.2","sperm associated antigen 11B isoform c precursor","113",""
> "Q9CR23-1","NP_001153617.1","transmembrane protein 9 precursor","183",""
8179c8173
< "O35083-1","NP_061350.3","1-acyl-sn-glycerol-3-phosphate acyltransferase alpha precursor","285",""
---
> "Q64327-1","NP_001264238.1","male-enhanced antigen 1 isoform a","215",""
8182d8175
< "Q9WTZ2-1","NP_062683.3","membrane-bound transcription factor site-1 protease precursor","1052",""
8186c8179
< "Q8BXN9-1","NP_776095.2","transmembrane protein 87A isoform 1","560",""
---
> "Q8K2C7-1","NP_001164497.1","protein OS-9 isoform 1 precursor","672",""
8191d8183
< "Q04646-1","NP_439888.1","sodium/potassium-transporting ATPase subunit gamma isoform b","64","This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Multiple transcript variants have been described for this gene that are expressed in tissue-specific and developmental stage-specific patterns and encode proteins that differ at the N-terminus. [provided by RefSeq, Sep 2009]. "
8193a8186
> "Q80U28-1","NP_001171190.1","MAP kinase-activating death domain protein isoform 10","1577",""
8195a8189,8190
> "Q8BVE8-1","NP_001074571.2","histone-lysine N-methyltransferase NSD2 isoform 1","1366",""
> "Q7TQA1-1","NP_808259.2","immunoglobulin superfamily member 1 isoform long precursor","1317",""
8197d8191
< "Q8K4N2-1","NP_694755.1","sperm-associated antigen 11 precursor","69",""
8200,8202c8194
< "Q9CR23-1","NP_079715.1","transmembrane protein 9 precursor","183",""
< "Q8K2C7-1","NP_808282.2","protein OS-9 isoform 2 precursor","617",""
< "Q8K385-1","NP_033172.2","ferric-chelate reductase 1 precursor","592",""
---
> "O08677-1","NP_001095881.1","kininogen-1 isoform 1 precursor","661",""
8205d8196
< "Q63ZW7-1","NP_766284.2","inaD-like protein isoform 1","1834","This gene encodes a multivalent PDZ domain protein, which is expressed exclusively in brain and kidney. This protein selectively interacts with inward rectifier K+ (Kir) family members, N-methyl-D-aspartate receptor subunits, neurexins and neuroligins, as well as cell surface molecules enriched in synaptic membranes. Thus, this protein may serve as a scaffold that brings structurally diverse but functionally connected proteins into close proximity at the synapse. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. "
8209d8199
< "Q64518-1","NP_058025.2","sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform b","1038",""
8211c8201,8203
< "P70704-1","NP_033857.1","phospholipid-transporting ATPase IA isoform b","1149",""
---
> "O70139-1","NP_001034479.1","cAMP-dependent protein kinase inhibitor gamma isoform 1","76",""
> "Q8K209-1","NP_001185823.1","adhesion G-protein coupled receptor G1 precursor","687",""
> "Q8BXN9-1","NP_001103966.1","transmembrane protein 87A isoform 2","559",""
8214d8205
< "Q03141-1","NP_073712.2","MAP/microtubule affinity-regulating kinase 3 isoform 2","729",""
8217d8207
< "P63280-1","NP_035795.1","SUMO-conjugating enzyme UBC9","158",""
8220d8209
< "O70309-1","NP_034710.2","integrin beta-5 isoform 2 precursor","816",""
8223,8224d8211
< "Q8R183-1","NP_599010.4","T-cell immunoglobulin and mucin domain-containing protein 2 precursor","305",""
< "Q99MS3-1","NP_291042.2","mpv17-like protein isoform 1","194",""
8227c8214
< "Q8R007-1","NP_082169.2","nectin-4 isoform a precursor","508",""
---
> "Q8BHB3-1","NP_001153121.1","lymphocyte transmembrane adapter 1","407",""
8229a8217
> "Q6P902-1","NP_001139474.1","thioredoxin domain-containing protein 2 isoform 1","550",""
8234d8221
< "Q9D659-1","NP_083008.1","V-type immunoglobulin domain-containing suppressor of T-cell activation isoform 1 precursor","309",""
8237d8223
< "Q9CZ42-1","NP_081271.2","ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform 1","365",""
8238a8225
> "P0DN90-1","NP_001257424.1","transmembrane protein 254b isoform 1","123",""
8242d8228
< "Q9CR63-1","NP_079737.1","cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform 1","106",""
8247d8232
< "Q1ERP8-1","NP_082263.2","CMRF35-like molecule 9 isoform 4 precursor","287",""
8248a8234
> "O35083-1","NP_001156851.1","1-acyl-sn-glycerol-3-phosphate acyltransferase alpha precursor","285",""
8252a8239,8240
> "Q9CZ42-1","NP_001177286.1","ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform 2","327",""
> "Q9R0Q1-1","NP_001277646.1","synaptotagmin-like protein 4 isoform 2","502",""
8256c8244
< "O88848-1","NP_062639.3","ADP-ribosylation factor-like protein 6 isoform 1","186",""
---
> "Q9WTZ2-1","NP_001161382.1","membrane-bound transcription factor site-1 protease precursor","1052",""
8258d8245
< "Q60716-1","NP_035161.2","prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor","537",""
8263c8250
< "Q8K209-1","NP_061370.2","adhesion G-protein coupled receptor G1 precursor","687",""
---
> "Q61139-1","NP_001268863.1","proprotein convertase subtilisin/kexin type 7 precursor","770",""
8268,8269c8255
< "Q9JLC3-1","NP_038787.1","methionine-R-sulfoxide reductase B1","116","The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2016]. "
< "P97808-1","NP_032787.1","FXYD domain-containing ion transport regulator 5 isoform a precursor","178","This gene encodes a precursor protein that is member of the FXYD family of transmembrane glycoproteins. Like most members of the FXYD family, the encoded protein is a subunit of the sodium-potassium adenosine triphosphatase pump. FXYD family members have tissue-specific expression and differentially regulate the activity of this pump. The protein encoded by this gene also plays a role in cell adhesion and motility. The orthologous human protein inhibits epithelial cadherin, a calcium-dependent adhesion protein and is associated with cancer (promotes metastasis). Alternative splicing of this mouse gene results in multiple transcript variants. [provided by RefSeq, Dec 2013]. "
---
> "P63280-1","NP_001171080.1","SUMO-conjugating enzyme UBC9","158",""
8272c8258
< "Q3U1F9-1","NP_444412.2","phosphoprotein associated with glycosphingolipid-enriched microdomains 1","429",""
---
> "Q9QZ23-1","NP_001164062.1","NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform 1 precursor","256",""
8274a8261
> "Q9R0N6-1","NP_001272786.1","synaptotagmin-8 isoform b","389",""
8276,8277c8263,8264
< "Q9DBM0-1","NP_080456.1","ATP-binding cassette sub-family G member 8 isoform 1","673",""
< "Q64327-1","NP_034917.1","male-enhanced antigen 1 isoform b","174",""
---
> "O08915-1","NP_001263213.1","AH receptor-interacting protein","330","This gene encodes an Hsp90-associated protein that is localized to the cytoplasm. The encoded protein interacts with the aryl hydrocarbon receptor (AhR) and the tyrosine kinase receptor RET, inhibits AhR ubiquitination, and regulates the intracellular localization of AhR. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
> "Q9CR63-1","NP_001296737.1","cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform 2","79",""
8280d8266
< "Q8R3S2-1","NP_666285.1","tetraspanin-33 isoform 1","283","This gene encodes a member of the tetraspanin family which typically have four transmembrane domains. The encoded protein may be involved in the regulation of erythropoiesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. "
8281a8268
> "O35405-1","NP_001304284.1","phospholipase D3","488",""
8282a8270,8271
> "Q8CIA9-1","NP_001077370.1","hippocampus abundant transcript-like protein 1","507",""
> "Q05685-1","NP_001290160.1","folate receptor beta precursor","251","This gene encodes a receptor protein located on the plasma membrane that mediates folate uptake by cells. Mice lacking the product of this gene show no defects in embryonic development and grow normally into fertile adults. However, such mice were found to be highly susceptible to the teratogenic effects of arsenic. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]. "
8286,8287c8275,8276
< "Q61139-1","NP_032820.2","proprotein convertase subtilisin/kexin type 7 precursor","770",""
< "Q9Z188-1","NP_034222.1","dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p65","589",""
---
> "Q5SSL4-1","NP_001278115.1","active breakpoint cluster region-related protein isoform 4","641",""
> "Q80Z24-1","NP_001034183.1","neuronal growth regulator 1 isoform a precursor","348",""
8288a8278
> "Q04646-1","NP_031529.2","sodium/potassium-transporting ATPase subunit gamma isoform a","70","This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Multiple transcript variants have been described for this gene that are expressed in tissue-specific and developmental stage-specific patterns and encode proteins that differ at the N-terminus. [provided by RefSeq, Sep 2009]. "
8292d8281
< "Q9R0N6-1","NP_061272.2","synaptotagmin-8 isoform a","395",""
8294a8284
> "Q9CPV2-1","NP_001334380.1","anaphase-promoting complex subunit 16 isoform 2","129",""
8299d8288
< "O35405-1","NP_035246.1","phospholipase D3","488",""
8302d8290
< "Q9QXD1-1","NP_444345.2","peroxisomal acyl-coenzyme A oxidase 2","681",""
8306a8295
> "Q8K135-1","NP_001030602.1","dyslexia-associated protein KIAA0319-like protein isoform 1","1085",""
8307a8297
> "Q61112-1","NP_001289396.1","45 kDa calcium-binding protein isoform 1 precursor","361","This gene encodes a member of the CREC family. The encoded protein contains multiple calcium-binding EF-hand motifs. This protein localizes to the Golgi lumen and may be involved in regulating calcium dependent cellular activities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
8309c8299
< "Q9QXT8-1","NP_062763.2","calsenilin isoform a","256",""
---
> "Q921T2-1","NP_001153490.1","torsin-1A-interacting protein 1 isoform 1","576",""
8311a8302
> "Q571E4-1","NP_001180574.1","N-acetylgalactosamine-6-sulfatase isoform 2 precursor","440",""
8312a8304
> "Q8C2B3-1","NP_001191204.1","histone deacetylase 7 isoform 1","953",""
8314c8306
< "Q6NXH3-1","NP_082763.3","vasculin isoform 2","493",""
---
> "Q8R3S2-1","NP_001288336.1","tetraspanin-33 isoform 2","282","This gene encodes a member of the tetraspanin family which typically have four transmembrane domains. The encoded protein may be involved in the regulation of erythropoiesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. "
8316,8317d8307
< "Q8BSY0-1","NP_075553.2","aspartyl/asparaginyl beta-hydroxylase isoform 1","741",""
< "Q60597-1","NP_035086.2","2-oxoglutarate dehydrogenase, mitochondrial isoform 3 precursor","1023",""
8318a8309
> "Q8BMQ8-1","NP_001041608.1","vacuolar fusion protein MON1 homolog B","553",""
8320c8311,8312
< "Q7TSA3-1","NP_808252.1","B- and T-lymphocyte attenuator isoform 2 precursor","305",""
---
> "Q8R007-1","NP_001116152.1","nectin-4 isoform b precursor","483",""
> "Q61481-4","NP_001009978.1","calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 7","456",""
8321a8314
> "Q60597-1","NP_001239211.1","2-oxoglutarate dehydrogenase, mitochondrial isoform 1","1038",""
8323,8324c8316
< "O08677-1","NP_075614.1","kininogen-1 isoform 2 precursor","432",""
< "Q64514-1","NP_033444.1","tripeptidyl-peptidase 2 isoform 1","1262",""
---
> "Q80YV4-1","NP_001292733.1","pantothenate kinase 4 isoform 1","820",""
8327d8318
< "Q8BVE8-1","NP_780440.2","histone-lysine N-methyltransferase NSD2 isoform 2","1365",""
8328a8320
> "Q9EQG7-1","NP_001162091.1","ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 1 precursor","477",""
8339d8330
< "Q9CPV2-1","NP_079790.1","anaphase-promoting complex subunit 16 isoform 1","110",""
8342c8333,8335
< "Q9CS84-1","NP_796258.2","neurexin-1 isoform 2 precursor","1495","This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. Alternative splicing and promoter usage result in multiple transcript variants. [provided by RefSeq, Nov 2016]. "
---
> "Q4KMM3-1","NP_001123635.1","oxidation resistance protein 1 isoform B","751",""
> "Q9Z188-1","NP_001033046.1","dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p69","629",""
> "Q69ZR9-1","NP_001108351.1","protein TASOR isoform 1","1640",""
8344c8337
< "Q6ZWY8-1","NP_079560.1","thymosin beta-10","44",""
---
> "O70309-1","NP_001139356.1","integrin beta-5 isoform 1 precursor","799",""
8346d8338
< "O70139-1","NP_035236.1","cAMP-dependent protein kinase inhibitor gamma isoform 1","76",""
8348d8339
< "Q8BHC7-1","NP_084053.3","rhomboid-related protein 4","315",""
8349a8341
> "O35136-1","NP_001106679.1","neural cell adhesion molecule 2 isoform a precursor","837",""
8355a8348
> "Q9JII5-1","NP_001116076.1","DAZ-associated protein 1 isoform b","406",""
8359,8360c8352
< "Q571E4-1","NP_057931.3","N-acetylgalactosamine-6-sulfatase isoform 1 precursor","520",""
< "Q80YV4-1","NP_766578.2","pantothenate kinase 4 isoform 2","773",""
---
> "O88848-1","NP_001334173.1","ADP-ribosylation factor-like protein 6 isoform 2","193",""
8362,8364c8354
< "Q8BH26-1","NP_796114.1","transmembrane protein 251 isoform 1","163",""
< "O35136-1","NP_035084.1","neural cell adhesion molecule 2 isoform b precursor","727",""
< "Q61112-1","NP_035471.1","45 kDa calcium-binding protein isoform 1 precursor","361","This gene encodes a member of the CREC family. The encoded protein contains multiple calcium-binding EF-hand motifs. This protein localizes to the Golgi lumen and may be involved in regulating calcium dependent cellular activities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
---
> "Q6NXH3-1","NP_001116435.1","vasculin isoform 1","473",""
8366a8357
> "Q8K385-1","NP_001106950.1","ferric-chelate reductase 1 precursor","592",""
8368d8358
< "Q921T2-1","NP_659040.2","torsin-1A-interacting protein 1 isoform 2","520",""
8370d8359
< "Q80XR2-1","NP_778190.3","calcium-transporting ATPase type 2C member 1 isoform 2","918",""
8373a8363
> "Q8C167-1","NP_001157094.1","prolyl endopeptidase-like isoform a","725",""
8377d8366
< "P48453-1","NP_032940.1","serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform 1","525",""
8379d8367
< "Q8BMQ8-1","NP_766603.1","vacuolar fusion protein MON1 homolog B","553",""
8383d8370
< "Q9EQG7-1","NP_114392.1","ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 1 precursor","477",""
8386a8374
> "Q3UHK6-1","NP_001297689.1","teneurin-4 isoform 1","2833",""
8389c8377,8378
< "Q8C2B3-1","NP_062518.2","histone deacetylase 7 isoform 4","938",""
---
> "Q60716-1","NP_001129548.1","prolyl 4-hydroxylase subunit alpha-2 isoform 1 precursor","535",""
> "P97808-1","NP_001104543.1","FXYD domain-containing ion transport regulator 5 isoform a precursor","178","This gene encodes a precursor protein that is member of the FXYD family of transmembrane glycoproteins. Like most members of the FXYD family, the encoded protein is a subunit of the sodium-potassium adenosine triphosphatase pump. FXYD family members have tissue-specific expression and differentially regulate the activity of this pump. The protein encoded by this gene also plays a role in cell adhesion and motility. The orthologous human protein inhibits epithelial cadherin, a calcium-dependent adhesion protein and is associated with cancer (promotes metastasis). Alternative splicing of this mouse gene results in multiple transcript variants. [provided by RefSeq, Dec 2013]. "
8393d8381
< "Q9R0Q1-1","NP_038785.1","synaptotagmin-like protein 4 isoform 1","673",""
8395c8383,8385
< "Q8CIA9-1","NP_598441.3","hippocampus abundant transcript-like protein 1","507",""
---
> "Q9D659-1","NP_001153044.1","V-type immunoglobulin domain-containing suppressor of T-cell activation isoform 2 precursor","308",""
> "Q9DBM0-1","NP_001272934.1","ATP-binding cassette sub-family G member 8 isoform 2","546",""
> "Q8BSY0-1","NP_001171321.1","aspartyl/asparaginyl beta-hydroxylase isoform 4","310",""
8397a8388
> "Q64518-1","NP_001156809.1","sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform c","1026",""
8399a8391
> "Q1ERP8-1","NP_001154183.1","CMRF35-like molecule 9 isoform 1 precursor","415",""
8402d8393
< "Q9JLL3-1","NP_038897.4","tumor necrosis factor receptor superfamily member 19 precursor","416",""
8409d8399
< "Q9QZ23-1","NP_064429.2","NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform 2 precursor","255",""
8418d8407
< "O08915-1","NP_057875.1","AH receptor-interacting protein","330","This gene encodes an Hsp90-associated protein that is localized to the cytoplasm. The encoded protein interacts with the aryl hydrocarbon receptor (AhR) and the tyrosine kinase receptor RET, inhibits AhR ubiquitination, and regulates the intracellular localization of AhR. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
8431,8432c8420,8421
< "Q80Z24-1","NP_796248.1","neuronal growth regulator 1 isoform b precursor","329",""
< "Q8BHB3-1","NP_766430.3","lymphocyte transmembrane adapter 1","407",""
---
> "Q3U1F9-1","NP_001181960.1","phosphoprotein associated with glycosphingolipid-enriched microdomains 1","429",""
> "Q8BHC7-1","NP_001116157.1","rhomboid-related protein 4","315",""
8436d8424
< "Q8CI51-1","NP_062782.2","PDZ and LIM domain protein 5 isoform ENH1","591",""
8439d8426
< "Q9JII5-1","NP_573451.2","DAZ-associated protein 1 isoform a","405",""
8440a8428,8429
> "O70589-1","NP_001271432.1","peripheral plasma membrane protein CASK isoform 1","926",""
> "Q8R183-1","NP_001154827.1","T-cell immunoglobulin and mucin domain-containing protein 2 precursor","305",""
8442,8443d8430
< "Q9QYE3-1","NP_057916.1","B-cell lymphoma/leukemia 11A isoform 1","773",""
< "Q3UHK6-1","NP_035988.2","teneurin-4 isoform 2","2796",""
8444a8432
> "P48453-1","NP_001297355.1","serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform 2","524",""
8447d8434
< "Q80U28-1","NP_663502.3","MAP kinase-activating death domain protein isoform 9","1558",""
8451c8438,8439
< "Q8C650-1","NP_001020082.1","septin-10 isoform 2","427",""
---
> "Q3UN02-1","NP_001074540.1","lysocardiolipin acyltransferase 1","376",""
> "Q9R1T4-1","NP_001170794.1","septin-6 isoform 3","428",""
8454c8442
< "Q8C1B7-1","NP_001297600.1","septin-11 isoform 2","425",""
---
> "Q8VD66-1","NP_001192110.1","(Lyso)-N-acylphosphatidylethanolamine lipase isoform 2","318",""
8455a8444
> "Q80VA0-1","NP_001161453.1","N-acetylgalactosaminyltransferase 7 isoform 2","657",""
8458,8459d8446
< "Q3UN02-1","NP_001171439.1","lysocardiolipin acyltransferase 1","376",""
< "Q80VA0-1","NP_653332.3","N-acetylgalactosaminyltransferase 7 isoform 1","657",""
8460a8448
> "Q8C1B7-1","NP_001009818.1","septin-11 isoform 3","429",""
8462d8449
< "Q9R1T4-1","NP_064326.2","septin-6 isoform 2","429",""
8464d8450
< "Q99JT6-1","NP_080984.1","TLC domain-containing protein 1 isoform a precursor","247",""
8465a8452
> "Q99JT6-1","NP_001278165.1","TLC domain-containing protein 1 isoform c","230",""
8467d8453
< "Q7TSH6-1","NP_849254.2","SR-related and CTD-associated factor 4 isoform 1","1209",""
8474d8459
< "Q8BX10-1","NP_082549.2","serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 2","287",""
8477,8478c8462
< "Q4KMM3-1","NP_570955.1","oxidation resistance protein 1 isoform A","778",""
< "Q9CQ92-1","NP_079838.1","mitochondrial fission 1 protein isoform 1","152",""
---
> "Q9CQ92-1","NP_001156715.1","mitochondrial fission 1 protein isoform 2","145",""
8480a8465
> "Q8BX10-1","NP_001157010.1","serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 1","288",""
8482c8467
< "P06240-1","NP_034823.1","proto-oncogene tyrosine-protein kinase LCK isoform b","509",""
---
> "Q9QYE3-1","NP_001152761.1","B-cell lymphoma/leukemia 11A isoform 2","243",""
8484a8470
> "Q07646-1","NP_001239221.1","mesoderm-specific transcript protein isoform 1","342",""
8488,8489d8473
< "Q9CY57-1","NP_075704.2","chromatin target of PRMT1 protein isoform 3","224",""
< "O89032-1","NP_032044.2","SH3 and PX domain-containing protein 2A isoform 1","1124",""
8493a8478
> "Q8R092-3","NP_001274016.1","uncharacterized protein C1orf43 homolog isoform 1","253",""
8495,8497c8480
< "Q8K299-1","NP_083179.2","scavenger receptor class A member 5 isoform 1","491",""
< "Q9D486-1","NP_083217.1","C-Maf-inducing protein isoform 2","685",""
< "Q9JJ57-1","NP_081674.2","Kv channel-interacting protein 1 isoform B","216",""
---
> "P70257-3","NP_001075451.1","nuclear factor 1 X-type isoform 1","441",""
8500d8482
< "P24527-1","NP_032543.2","leukotriene A-4 hydrolase isoform 1","611","The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
8502,8506c8484
< "Q9WU78-1","NP_035182.2","programmed cell death 6-interacting protein isoform 3","869",""
< "Q4VA53-1","NP_780519.3","sister chromatid cohesion protein PDS5 homolog B isoform 1","1446",""
< "Q9Z2X2-1","NP_058579.2","26S proteasome non-ATPase regulatory subunit 10 isoform 1","231",""
< "Q3UIW5-1","NP_057907.2","RING finger protein 10 isoform 2","804","The protein encoding this gene is a member of the really interesting new gene finger protein family. Members of this family contain protein motifs similar to zinc finger domains and are involved in many processes that include transcriptional regulation, DNA repair and signal transduction. Expression of this gene is upregulated during neuronal differentiation of cultured cells, and inhibition of its expression impairs differentiation and cell cycle exit, providing evidence for a function in neuronal differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
< "Q80YV2-1","NP_766323.1","nuclear-interacting partner of ALK isoform 2","481",""
---
> "Q9CY57-1","NP_001280705.1","chromatin target of PRMT1 protein isoform 1","249",""
8509a8488
> "Q9JJ57-1","NP_001177814.1","Kv channel-interacting protein 1 isoform A","227",""
8513a8493,8496
> "Q7TSY6-1","NP_001139764.1","CUGBP Elav-like family member 4 isoform 22","504",""
> "P70662-1","NP_001106879.1","LIM domain-binding protein 1 isoform 1","411",""
> "P06240-1","NP_001155905.1","proto-oncogene tyrosine-protein kinase LCK isoform b","509",""
> "Q9D486-1","NP_001156734.1","C-Maf-inducing protein isoform 1","773",""
8515a8499,8500
> "Q9Z110-1","NP_062672.2","delta-1-pyrroline-5-carboxylate synthase isoform 1","795",""
> "O89032-1","NP_001158189.1","SH3 and PX domain-containing protein 2A isoform 2","1096",""
8517c8502,8503
< "P70662-1","NP_034827.1","LIM domain-binding protein 1 isoform 2","375",""
---
> "Q3UIW5-1","NP_001289377.1","RING finger protein 10 isoform 1","805","The protein encoding this gene is a member of the really interesting new gene finger protein family. Members of this family contain protein motifs similar to zinc finger domains and are involved in many processes that include transcriptional regulation, DNA repair and signal transduction. Expression of this gene is upregulated during neuronal differentiation of cultured cells, and inhibition of its expression impairs differentiation and cell cycle exit, providing evidence for a function in neuronal differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
> "Q9WU78-1","NP_001158149.1","programmed cell death 6-interacting protein isoform 1","874",""
8518a8505,8506
> "P24527-1","NP_001300826.1","leukotriene A-4 hydrolase isoform 2","532","The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
> "Q4VA53-1","NP_001333432.1","sister chromatid cohesion protein PDS5 homolog B isoform 2","1448",""
8521d8508
< "P70257-3","NP_035036.1","nuclear factor 1 X-type isoform 2","400",""
8522a8510,8511
> "Q8K299-1","NP_001161790.1","scavenger receptor class A member 5 isoform 2","387",""
> "Q80YV2-1","NP_001298015.1","nuclear-interacting partner of ALK isoform 1","501",""
8525d8513
< "Q07646-1","NP_032616.1","mesoderm-specific transcript protein isoform 2","335",""
8529,8530c8517
< "Q91VW9-1","NP_076174.3","zinc finger protein with KRAB and SCAN domains 3 isoform a","553",""
< "Q9Z110-1","NP_705782.2","delta-1-pyrroline-5-carboxylate synthase isoform 2","793",""
---
> "Q9Z2X2-1","NP_001157649.1","26S proteasome non-ATPase regulatory subunit 10 isoform 2","151",""
8532,8533c8519
< "Q8R092-3","NP_081776.2","uncharacterized protein C1orf43 homolog isoform 2","189",""
< "Q6P5G3-1","NP_598773.2","MBT domain-containing protein 1 isoform 1","631",""
---
> "Q91VW9-1","NP_001139250.1","zinc finger protein with KRAB and SCAN domains 3 isoform a","553",""
8534a8521
> "Q9JII1-1","NP_001277366.1","phosphatidylinositol polyphosphate 5-phosphatase type IV isoform b","605",""
8536d8522
< "Q9JII1-1","NP_149125.1","phosphatidylinositol polyphosphate 5-phosphatase type IV isoform a","647",""
8541c8527
< "Q8R3G1-1","NP_666266.1","nuclear inhibitor of protein phosphatase 1 isoform 1","351",""
---
> "Q9JIM1-1","NP_001186042.1","equilibrative nucleoside transporter 1 isoform 1","460",""
8543d8528
< "Q9JIM1-1","NP_075018.1","equilibrative nucleoside transporter 1 isoform 2","458",""
8545a8531
> "Q8R3G1-1","NP_001277654.1","nuclear inhibitor of protein phosphatase 1 isoform 2","350",""
8547a8534,8535
> "Q91VU6-1","NP_001185938.1","DDB1- and CUL4-associated factor 11","549",""
> "Q61127-1","NP_001116367.1","NGFI-A-binding protein 2 isoform 2","461",""
8548a8537
> "O54714-1","NP_001159421.1","E3 SUMO-protein ligase PIAS3 isoform 3","628",""
8551c8540
< "Q61127-1","NP_032694.2","NGFI-A-binding protein 2 isoform 1","525",""
---
> "Q80UN1-1","NP_001104498.1","BTB/POZ domain-containing protein KCTD9 isoform a","389",""
8554d8542
< "Q80UN1-1","NP_598834.2","BTB/POZ domain-containing protein KCTD9 isoform b","339",""
8557a8546
> "Q14AX6-1","NP_001103096.1","cyclin-dependent kinase 12 isoform 1","1484",""
8562,8564d8550
< "Q91VU6-1","NP_598495.1","DDB1- and CUL4-associated factor 11","549",""
< "O54714-1","NP_666247.1","E3 SUMO-protein ligase PIAS3 isoform 1","619",""
< "P51141-1","NP_034221.3","segment polarity protein dishevelled homolog DVL-1 isoform 1","695","The protein encoded by this gene is a member of the Dishevelled family of proteins. These proteins have an N-terminal Dishevelled/Axin domain, a Dishevelled, EGL-10, Plextrin domain, a central PDZ domain, and a C-terminal domain of approximately 200 amino acids. They regulate both canonical and non-canonical Wnt signaling as well as planar cell polarity pathways. Mice deficient for this gene are viable and fertile but display reduced social interaction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
8570d8555
< "Q14AX6-1","NP_081228.2","cyclin-dependent kinase 12 isoform 3","1258",""
8573a8559
> "Q9BCZ4-1","NP_001335175.1","selenoprotein S isoform 2","167","This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion (PMID:23614019). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2017]. "
8575,8576c8561
< "Q6P9K9-1","NP_766132.2","neurexin 3 isoform 2","1100","This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. [provided by RefSeq, Dec 2012]. "
< "Q9BCZ4-1","NP_077759.3","selenoprotein S isoform 1","190","This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion (PMID:23614019). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2017]. "
---
> "Q8R1P5-1","NP_001157898.1","potassium channel subfamily K member 13","405",""
8579,8580c8564
< "Q6DFV7-1","NP_766083.3","nuclear receptor coactivator 7 isoform 1","943",""
< "P62984-1","NP_063936.1","ubiquitin-60S ribosomal protein L40 precursor","128",""
---
> "Q6DFV7-1","NP_001104737.1","nuclear receptor coactivator 7 isoform 2","221",""
8582c8566,8567
< "Q8R1P5-1","NP_666149.1","potassium channel subfamily K member 13","405",""
---
> "Q80YA3-1","NP_001034195.2","phospholipase DDHD1 isoform 1","856",""
> "Q69ZN7-1","NP_001093104.1","myoferlin isoform 2","2048","The protein encoded by this gene is a member of the ferlin family of proteins, which have been implicated in fusion events in muscle tissue. Members of this family have a carboxy-terminal single pass transmembrane domain and multiple C2 domains, which bind negatively charged phospholipids in the presence of calcium ions. This gene is expressed at high levels in myoblasts and upregulated in damaged skeletal muscle. Mice deficient in this protein display defects in myoblast fusion, muscle regeneration, and angiogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. "
8585a8571
> "Q6P9K9-1","NP_001185516.2","neurexin 3 isoform 1 precursor","1571","This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. [provided by RefSeq, Dec 2012]. "
8587d8572
< "Q80YA3-1","NP_789815.3","phospholipase DDHD1 isoform 2","884",""
8593a8579,8580
> "Q6ZPR5-1","NP_001158081.1","sphingomyelin phosphodiesterase 4 isoform 4","807",""
> "Q8BVD7-1","NP_001128644.1","complement C1q tumor necrosis factor-related protein 7 isoform a precursor","296",""
8595c8582
< "Q8CGN4-1","NP_778211.2","BCL-6 corepressor isoform d","1707",""
---
> "C0HKD9-1","NP_001075444.1","microfibrillar-associated protein 1B","439",""
8596a8584
> "Q99LE2-1","NP_001033792.1","probable G-protein coupled receptor 146","333",""
8599a8588
> "Q9JKY7-1","NP_001156944.1","cytochrome P450, family 2, subfamily d, polypeptide 22","500",""
8600a8590
> "Q8BFW7-1","NP_001139424.1","lipoma-preferred partner homolog isoform 1","613",""
8602,8603d8591
< "P97300-2","NP_033171.2","neuroplastin isoform 1 precursor","281",""
< "Q8CEE7-1","NP_780581.1","retinol dehydrogenase 13 isoform 1 precursor","334",""
8607c8595,8597
< "Q3UIL6-1","NP_766331.1","pleckstrin homology domain-containing family A member 7 isoform 3","1030",""
---
> "Q8CEE7-1","NP_001277338.1","retinol dehydrogenase 13 isoform 2 precursor","299",""
> "P0DP28-1","NP_031615.1","calmodulin-2 isoform 1","149",""
> "Q8JZL7-1","NP_665838.1","ras-GEF domain-containing family member 1B isoform 1","473",""
8608a8599
> "Q3US41-1","NP_001277312.1","epithelial splicing regulatory protein 1 isoform 2","680",""
8614d8604
< "Q8K262-1","NP_997112.1","placenta-specific protein 9 precursor","108",""
8616d8605
< "C0HKD9-1","NP_080496.1","microfibrillar-associated protein 1A","439",""
8618,8622c8607,8609
< "O54988-1","NP_033315.2","STE20-like serine/threonine-protein kinase isoform 1","1233",""
< "Q8K479-1","NP_663588.2","complement C1q tumor necrosis factor-related protein 5 precursor","243","The protein encoded by this gene is a member of the C1q/tumor necrosis factor superfamily. This family member is a secretory protein that functions in eye development. Mutations in this gene are thought to underlie the pathophysiology of late-onset retinal degeneration (L-ORD) and early-onset long anterior zonules (LAZ). Bicistronic transcripts composed of the coding sequences for this gene (C1qtnf5) and the membrane-type frizzled-related protein gene (Mfrp) have been identified, and the resulting products can interact with each other. Co-transcription of C1qtnf5 and Mfrp has been observed in both human and mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]. "
< "Q8BFW7-1","NP_848780.3","lipoma-preferred partner homolog isoform 1","613",""
< "Q99LE2-1","NP_084534.2","probable G-protein coupled receptor 146","333",""
< "Q9JKY7-1","NP_062797.3","cytochrome P450, family 2, subfamily d, polypeptide 22","500",""
---
> "Q8K480-1","NP_001177242.1","complement C1q tumor necrosis factor-related protein 5 precursor","243","The protein encoded by this gene is a member of the C1q/tumor necrosis factor superfamily. This family member is a secretory protein that functions in eye development. Mutations in this gene are thought to underlie the pathophysiology of late-onset retinal degeneration (L-ORD) and early-onset long anterior zonules (LAZ). Bicistronic transcripts composed of the coding sequences for this gene (C1qtnf5) and the membrane-type frizzled-related protein gene (Mfrp) have been identified, and the resulting products can interact with each other. Co-transcription of C1qtnf5 and Mfrp has been observed in both human and mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]. "
> "O54988-1","NP_001158111.1","STE20-like serine/threonine-protein kinase isoform 2","1202",""
> "Q9QXE2-1","NP_001317435.1","DNA polymerase lambda isoform 1","573",""
8625c8612
< "P58390-1","NP_536713.1","small conductance calcium-activated potassium channel protein 2 isoform SK2-S","574",""
---
> "Q6P1D5-1","NP_001240845.1","seizure 6-like protein isoform 1 precursor","963",""
8627d8613
< "Q8JZL7-1","NP_851835.1","ras-GEF domain-containing family member 1B isoform 2","472",""
8628a8615
> "P41241-1","NP_001291690.1","tyrosine-protein kinase CSK","450",""
8631c8618
< "Q8BN21-1","NP_081536.2","serine/threonine-protein kinase VRK2 isoform 1","503",""
---
> "P58390-1","NP_001299834.1","small conductance calcium-activated potassium channel protein 2 isoform SK2-L","849",""
8633c8620
< "P41241-1","NP_031809.2","tyrosine-protein kinase CSK","450",""
---
> "Q9ERH6-1","NP_001136409.1","modulator of apoptosis 1","352",""
8634a8622
> "Q6SJQ0-1","NP_001334583.1","CMRF35-like molecule 8 isoform 2 precursor","314",""
8642d8629
< "Q6P1D5-1","NP_064366.2","seizure 6-like protein isoform 2 precursor","962",""
8644,8646c8631
< "Q8K558-1","NP_082039.1","trem-like transcript 1 protein isoform 1 precursor","322",""
< "Q6ZPR5-1","NP_084221.2","sphingomyelin phosphodiesterase 4 isoform 1","823",""
< "Q9QXE2-1","NP_064416.1","DNA polymerase lambda isoform 1","573",""
---
> "Q99KG5-1","NP_001157656.1","lipolysis-stimulated lipoprotein receptor isoform 2 precursor","575",""
8650c8635
< "Q8BVD7-1","NP_780634.2","complement C1q tumor necrosis factor-related protein 7 isoform b precursor","289",""
---
> "Q8K479-1","NP_001035721.1","complement C1q tumor necrosis factor-related protein 5 precursor","243","The protein encoded by this gene is a member of the C1q/tumor necrosis factor superfamily. This family member is a secretory protein that functions in eye development. Mutations in this gene are thought to underlie the pathophysiology of late-onset retinal degeneration (L-ORD) and early-onset long anterior zonules (LAZ). Bicistronic transcripts composed of the coding sequences for this gene (C1qtnf5) and the membrane-type frizzled-related protein gene (Mfrp) have been identified, and the resulting products can interact with each other. Co-transcription of C1qtnf5 and Mfrp has been observed in both human and mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]. "
8652a8638,8639
> "Q3UIL6-1","NP_001292114.1","pleckstrin homology domain-containing family A member 7 isoform 1","1266",""
> "Q8BN21-1","NP_001239376.1","serine/threonine-protein kinase VRK2 isoform 2","454",""
8656d8642
< "Q9ERH6-1","NP_071718.1","modulator of apoptosis 1","352",""
8658a8645
> "Q8CGN4-1","NP_001161793.1","BCL-6 corepressor isoform d","1707",""
8661,8664c8648,8649
< "Q6SJQ0-1","NP_739564.1","CMRF35-like molecule 8 isoform 1 precursor","318",""
< "Q99KG5-1","NP_059101.1","lipolysis-stimulated lipoprotein receptor isoform 1 precursor","594",""
< "O70201-1","NP_033819.1","baculoviral IAP repeat-containing protein 5 isoform 1","140","This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008]. "
< "Q8CIF6-1","NP_758461.1","SID1 transmembrane family member 2 isoform 2 precursor","832",""
---
> "Q8VD58-1","NP_001070964.1","protein EVI2B precursor","444",""
> "Q3UDF0-1","NP_001171098.1","solute carrier family 2, facilitated glucose transporter member 6 isoform 2","443",""
8665a8651,8652
> "Q8CIF6-1","NP_001276597.1","SID1 transmembrane family member 2 isoform 1 precursor","853",""
> "O70201-1","NP_001012273.1","baculoviral IAP repeat-containing protein 5 isoform 3","121","This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008]. "
8667,8668c8654
< "Q3UDF0-1","NP_766247.2","solute carrier family 2, facilitated glucose transporter member 6 isoform 1","497",""
< "Q5DU57-1","NP_001297523.1","spermatogenesis-associated protein 13 isoform 2","574",""
---
> "Q5DU57-1","NP_001028444.1","spermatogenesis-associated protein 13 isoform 1","1244",""
8672,8674c8658
< "P13595-1","NP_035005.2","neural cell adhesion molecule 1 isoform 2 precursor","725",""
< "Q8CGS6-1","NP_084253.1","DNA polymerase theta isoform 1","2544",""
< "Q9JKF4-1","NP_064385.1","C-type lectin domain family 6 member A isoform 1","209",""
---
> "Q80U70-1","NP_001156490.1","polycomb protein Suz12 isoform 2","718","This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]. "
8680d8663
< "Q8VH37-1","NP_081658.1","histone deacetylase 8 isoform 1","377",""
8682d8664
< "Q8BN78-1","NP_064652.2","transcriptional regulator Kaiso","671",""
8683a8666
> "Q8CGS6-1","NP_001152841.1","DNA polymerase theta isoform 2","2265",""
8684a8668,8669
> "P13595-1","NP_001074914.1","neural cell adhesion molecule 1 isoform 1 precursor","848",""
> "Q05BC3-1","NP_001036800.1","echinoderm microtubule-associated protein-like 1 isoform 1","814",""
8685a8671
> "Q9JKF4-1","NP_001177250.1","C-type lectin domain family 6 member A isoform 3","175",""
8688c8674
< "Q80U70-1","NP_954666.1","polycomb protein Suz12 isoform 1","741","This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]. "
---
> "Q8BN78-1","NP_001072981.1","transcriptional regulator Kaiso","671",""
8689a8676
> "Q8VH37-1","NP_001300671.1","histone deacetylase 8 isoform 2","253",""
8697d8683
< "Q05BC3-1","NP_001273276.1","echinoderm microtubule-associated protein-like 1 isoform 4","800",""
8698a8685
> "Q810C0-1","NP_001154903.1","SLIT and NTRK-like protein 2 precursor","846",""
8701d8687
< "Q9JIX8-1","NP_075679.2","apoptotic chromatin condensation inducer in the nucleus isoform 2","1338",""
8703a8690
> "C0HKE7-1","NP_001171015.1","histone H2A type 1-O","130","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]. "
8704a8692
> "Q9QWH1-1","NP_001182012.1","polyhomeotic-like protein 2 isoform B","323",""
8705a8694
> "Q8BQ30-1","NP_001140182.1","phostensin","594",""
8709c8698
< "O70583-1","NP_034927.2","E3 ubiquitin-protein ligase Midline-1 isoform 1","680",""
---
> "Q9D6Y4-1","NP_001139024.1","BLOC-1-related complex subunit 8 isoform 1","120",""
8711,8712c8700
< "Q8R121-1","NP_659083.2","protein Z-dependent protease inhibitor isoform 1 precursor","448","The protein encoded by this gene is a member of the large serpin family of proteins, and is also known as serpin PZ-dependent protease inhibitor (ZPI or PZI). This protein is thought to play an important role in the regulation of coagulation. It directly inhibits factor XIa, and also inhibits factor Xa in the presence of calcium, phospholipids, and protein Z (PZ). Deficiencies in this gene lead to an increase in thrombosis. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Aug 2014]. "
< "Q68FG0-1","NP_001276626.1","zinc finger C4H2 domain-containing protein isoform 3","217",""
---
> "O88700-1","NP_001035992.1","Bloom syndrome protein homolog isoform 2","1416",""
8714d8701
< "Q91W18-1","NP_766193.3","tudor domain-containing protein 3 isoform 1","743",""
8717d8703
< "Q8BYH8-1","NP_796198.1","chromodomain-helicase-DNA-binding protein 9 isoform 2","2869",""
8720a8707
> "Q8K262-1","NP_001257432.1","predicted gene 10393 precursor","108",""
8724,8725c8711,8713
< "B2RUR8-1","NP_001020785.1","OTU domain-containing protein 7B","840",""
< "Q9D9Z5-1","NP_079876.1","DET1- and DDB1-associated protein 1 isoform 1","102",""
---
> "Q9QXN3-1","NP_001164378.1","activating signal cointegrator 1 isoform 2","539",""
> "Q9CSU0-1","NP_001278063.1","regulation of nuclear pre-mRNA domain-containing protein 1B isoform a","326",""
> "Q8R121-1","NP_001288333.1","protein Z-dependent protease inhibitor isoform 2 precursor","394","The protein encoded by this gene is a member of the large serpin family of proteins, and is also known as serpin PZ-dependent protease inhibitor (ZPI or PZI). This protein is thought to play an important role in the regulation of coagulation. It directly inhibits factor XIa, and also inhibits factor Xa in the presence of calcium, phospholipids, and protein Z (PZ). Deficiencies in this gene lead to an increase in thrombosis. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Aug 2014]. "
8729,8731c8717
< "Q3UEI1-1","NP_963901.1","cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 2","652",""
< "Q922Q5-1","NP_598821.1","adenosine 3'-phospho 5'-phosphosulfate transporter 2","369",""
< "Q3U3C9-1","NP_941073.2","genetic suppressor element 1 isoform 1","1223",""
---
> "B9EJ86-1","NP_001003717.1","oxysterol-binding protein-related protein 8 isoform b","847","This gene encodes a member of the oxysterol-binding protein (Osbp) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal Osbp-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. "
8736a8723
> "B2RUR8-1","NP_001020784.1","OTU domain-containing protein 7B","840",""
8737a8725
> "O70583-1","NP_001277433.1","E3 ubiquitin-protein ligase Midline-1 isoform 2","667",""
8739c8727
< "P17156-1","NP_032327.2","heat shock-related 70 kDa protein 2","633",""
---
> "Q3TXX3-1","NP_001158003.1","protrudin isoform 2","408",""
8740a8729,8730
> "P17156-1","NP_001002012.1","heat shock-related 70 kDa protein 2","633",""
> "Q8BG39-1","NP_001103223.1","synaptic vesicle glycoprotein 2B","683",""
8742d8731
< "O88700-1","NP_031576.4","Bloom syndrome protein homolog isoform 1","1419",""
8744d8732
< "B9EJ86-1","NP_780698.2","oxysterol-binding protein-related protein 8 isoform a","889","This gene encodes a member of the oxysterol-binding protein (Osbp) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal Osbp-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. "
8745a8734,8735
> "Q9EPU0-1","NP_001116301.1","regulator of nonsense transcripts 1 isoform a","1124",""
> "Q8R2F2-1","NP_001164473.1","sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 isoform 2","286",""
8752a8743
> "Q68FG0-1","NP_001003916.1","zinc finger C4H2 domain-containing protein isoform 1","224",""
8756a8748
> "P54823-1","NP_001104296.1","probable ATP-dependent RNA helicase DDX6","483",""
8760,8761c8752,8753
< "Q8BG39-1","NP_705807.2","synaptic vesicle glycoprotein 2B","683",""
< "Q9D6Y4-1","NP_001296770.1","BLOC-1-related complex subunit 8 isoform 3","113",""
---
> "Q9R0K7-1","NP_001031761.1","plasma membrane calcium-transporting ATPase 2 isoform 1","1198",""
> "Q91W18-1","NP_001240684.1","tudor domain-containing protein 3 isoform 2","716",""
8766,8767d8757
< "Q8BQ30-1","NP_780451.1","phostensin","594",""
< "Q8R2F2-1","NP_081575.2","sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 isoform 1","323",""
8769c8759
< "Q810C0-1","NP_942563.2","SLIT and NTRK-like protein 2 precursor","846",""
---
> "Q922Q5-1","NP_001163901.1","adenosine 3'-phospho 5'-phosphosulfate transporter 2","369",""
8771,8773c8761,8762
< "Q8BXK8-1","NP_835220.1","arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform 1","857",""
< "O88909-1","NP_112471.3","solute carrier family 22 member 8","537",""
< "P54823-1","NP_851841.2","probable ATP-dependent RNA helicase DDX6","483",""
---
> "Q0VGY8-1","NP_001277588.1","protein TANC1 isoform b","1849",""
> "Q3UEI1-1","NP_001297394.1","cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1","686",""
8781a8771
> "Q8BFR2-1","NP_001240648.1","follistatin-related protein 5 precursor","847",""
8785c8775
< "P47867-1","NP_033156.1","secretogranin-3 isoform 1 precursor","471",""
---
> "Q3U3C9-1","NP_001139368.1","genetic suppressor element 1 isoform 2","1213",""
8791c8781,8783
< "Q9CSU0-1","NP_081710.1","regulation of nuclear pre-mRNA domain-containing protein 1B isoform b","325",""
---
> "Q8K4K6-1","NP_001107811.1","pantothenate kinase 1 isoform 1","548",""
> "Q9WU56-1","NP_001020733.1","tRNA pseudouridine synthase A isoform 3","393",""
> "O88909-1","NP_001158106.1","solute carrier family 22 member 8","537",""
8794c8786
< "Q9QXN3-1","NP_062771.2","activating signal cointegrator 1 isoform 1","581",""
---
> "Q80T21-1","NP_001288634.1","ADAMTS-like protein 4 precursor","1036","The protein encoded by this gene is a member of the ADAMTS superfamily of secreted proteins, which contain a metalloprotease domain at the N-terminus and a C-terminal ancillary domain. ADAMTS-like proteins lack protease activity and resemble the ancillary domain of ADAMTS proteins. ADAMTS-like proteins have been implicated in regulation of the extracellular matrix. The encoded protein contains 7 thrombospondin type 1 repeats, a conserved extracellular domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. "
8795a8788
> "P27656-1","NP_001311401.1","hepatic triacylglycerol lipase isoform 1 precursor","510",""
8797d8789
< "Q9WU56-1","NP_062674.2","tRNA pseudouridine synthase A isoform 2","423",""
8798a8791
> "P12849-1","NP_001240819.1","cAMP-dependent protein kinase type I-beta regulatory subunit isoform a","381",""
8802a8796,8797
> "Q9Z205-1","NP_001020760.1","DNA-binding protein RFXANK isoform 2","259",""
> "Q8VBU8-1","NP_001103570.1","protein BANP isoform 1","545",""
8803a8799
> "Q9JIX8-1","NP_001078942.2","apoptotic chromatin condensation inducer in the nucleus isoform 4","1326",""
8809c8805
< "Q9QWH1-1","NP_061244.1","polyhomeotic-like protein 2 isoform A","850",""
---
> "Q8BYH8-1","NP_001297459.1","chromodomain-helicase-DNA-binding protein 9 isoform 1","2885",""
8811,8812d8806
< "Q8VBU8-1","NP_058092.2","protein BANP isoform 2","548",""
< "Q3TZX8-1","NP_083003.2","polynucleotide 5'-hydroxyl-kinase NOL9 isoform 2","671",""
8817,8818d8810
< "Q3TXX3-1","NP_796293.2","protrudin isoform 1","415",""
< "Q8K4K6-1","NP_076281.1","pantothenate kinase 1 isoform 2","373",""
8820,8823c8812,8813
< "P27656-1","NP_032306.2","hepatic triacylglycerol lipase isoform 1 precursor","510",""
< "Q9Z205-1","NP_035396.1","DNA-binding protein RFXANK isoform 1","269",""
< "P03953-1","NP_038487.1","complement factor D isoform 1 preproprotein","259","This gene encodes a serine protease that plays an important role in the alternative pathway of complement activation for pathogen recognition and elimination. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme that in turn cleaves factor B in the complement pathway. This gene is expressed in adipocytes and the mature enzyme is secreted into the bloodstream. Mice lacking the encoded product cannot initiate alternative pathway of complement activation. [provided by RefSeq, Jul 2016]. "
< "Q8BFR2-1","NP_848788.2","follistatin-related protein 5 precursor","847",""
---
> "Q9D9Z5-1","NP_001281187.1","DET1- and DDB1-associated protein 1 isoform 2","100",""
> "Q8BXK8-1","NP_001032213.1","arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform 2","804",""
8825d8814
< "Q80T21-1","NP_659148.2","ADAMTS-like protein 4 precursor","1036","The protein encoded by this gene is a member of the ADAMTS superfamily of secreted proteins, which contain a metalloprotease domain at the N-terminus and a C-terminal ancillary domain. ADAMTS-like proteins lack protease activity and resemble the ancillary domain of ADAMTS proteins. ADAMTS-like proteins have been implicated in regulation of the extracellular matrix. The encoded protein contains 7 thrombospondin type 1 repeats, a conserved extracellular domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. "
8832c8821,8822
< "Q3TRM8-1","NP_001193319.1","hexokinase-3 isoform 1","922",""
---
> "Q3TRM8-1","NP_001028417.1","hexokinase-3 isoform 1","922",""
> "Q68ED3-1","NP_001157969.1","terminal nucleotidyltransferase 4B isoform a","680",""
8834d8823
< "Q68ED3-1","NP_001157971.1","terminal nucleotidyltransferase 4B isoform b","637",""
8837c8826
< "Q8BJS8-1","NP_598853.3","mdm2-binding protein isoform 1","894",""
---
> "Q8K3W0-2","NP_653124.1","BRISC and BRCA1-A complex member 2 isoform V","383",""
8840a8830
> "P58771-1","NP_001157720.1","tropomyosin alpha-1 chain isoform Tpm1.1st","284",""
8842d8831
< "Q562D6-1","NP_083362.1","tRNA (adenine(37)-N6)-methyltransferase isoform 1","488",""
8844a8834
> "Q6P253-1","NP_001159646.1","dermokine isoform d precursor","493",""
8846a8837
> "Q91ZT9-1","NP_001164181.1","ankyrin repeat and SOCS box protein 8","288",""
8850d8840
< "Q99M87-1","NP_076135.3","dnaJ homolog subfamily A member 3, mitochondrial isoform 1","480",""
8852d8841
< "Q63880-1","NP_941074.1","carboxylesterase 3A isoform 1 precursor","571",""
8853a8843
> "Q07076-1","NP_001104264.1","annexin A7","463",""
8855d8844
< "P06801-1","NP_032641.2","NADP-dependent malic enzyme isoform 1","572",""
8860d8848
< "Q3UMR0-1","NP_839994.1","ankyrin repeat domain-containing protein 27 isoform 2","377",""
8870c8858
< "Q8CHI8-1","NP_775089.1","E1A-binding protein p400 isoform 2","2999",""
---
> "Q8CCA0-1","NP_001177662.1","DCN1-like protein 4 isoform C","257",""
8876a8865
> "Q8CIE2-1","NP_001005867.1","zinc finger MIZ domain-containing protein 2 isoform 2","888",""
8880d8868
< "Q8CCA0-1","NP_849227.1","DCN1-like protein 4 isoform B","292",""
8885d8872
< "Q3UF64-1","NP_766586.2","RING finger and transmembrane domain-containing protein 2 isoform 1","446",""
8891d8877
< "Q3UJK4-1","NP_062527.2","GTP-binding protein 2 isoform 1","602",""
8897d8882
< "Q9WU03-1","NP_035594.1","kunitz-type protease inhibitor 2 isoform a precursor","252",""
8901d8885
< "Q8K3W0-2","NP_851799.1","BRISC and BRCA1-A complex member 2 isoform II","245",""
8912c8896,8897
< "Q8R1X6-1","NP_659144.1","spartin isoform a","671",""
---
> "Q63880-1","NP_001158153.1","carboxylesterase 3A isoform 2 precursor","524",""
> "Q99L60-1","NP_001153104.1","V-type proton ATPase subunit C 2 isoform 1","437",""
8920c8905
< "Q91VD9-1","NP_663493.2","NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor","727",""
---
> "Q148W8-1","NP_001028516.2","inactive dual specificity phosphatase 27","1138",""
8922,8923c8907
< "Q69ZB0-1","NP_083191.2","leucine-rich repeat and coiled-coil domain-containing protein 1 isoform 3","993",""
< "Q3UH06-1","NP_081106.1","ras-responsive element-binding protein 1 isoform 1","1291",""
---
> "Q8CHI8-1","NP_083613.2","E1A-binding protein p400 isoform 1","3035",""
8925d8908
< "Q9JMB1-1","NP_954696.1","testicular haploid expressed gene protein isoform 2","351",""
8926a8910
> "Q3UJK4-1","NP_001139451.1","GTP-binding protein 2 isoform 2","514",""
8928a8913
> "Q8BJS8-1","NP_001161722.1","mdm2-binding protein isoform 2","629",""
8933a8919
> "B7ZWI3-1","NP_001030068.1","transmembrane protein 92 isoform 2 precursor","114",""
8936a8923
> "Q810F8-1","NP_001001320.1","T-box transcription factor TBX10 isoform 1","385",""
8941a8929
> "Q9DCZ4-1","NP_001186266.1","MICOS complex subunit Mic26 isoform 2","212",""
8944d8931
< "Q9DCZ4-1","NP_080949.2","MICOS complex subunit Mic26 isoform 1 precursor","198",""
8948d8934
< "Q8R4V2-1","NP_665687.1","dual specificity protein phosphatase 15 isoform 2","105",""
8955a8942
> "Q4VAA2-1","NP_780774.1","protein CDV3 isoform a","236",""
8957d8943
< "Q9JI75-1","NP_064678.1","ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1","231",""
8968d8953
< "P23249-1","NP_032645.2","putative helicase MOV-10 isoform b","1004",""
8969a8955,8956
> "Q8K1E0-1","NP_001161271.1","syntaxin-5","355",""
> "Q9WV98-1","NP_001020024.1","mitochondrial import inner membrane translocase subunit Tim9","89",""
8971d8957
< "Q8BIQ3-1","NP_082417.3","zinc finger protein 2 isoform a","427",""
8978d8963
< "O54946-1","NP_035977.2","dnaJ homolog subfamily B member 6 isoform c","242",""
8980,8981d8964
< "Q91ZT9-1","NP_084397.3","ankyrin repeat and SOCS box protein 8","288",""
< "Q05BQ1-1","NP_291086.2","protein turtle homolog A precursor","1179",""
8987,8988d8969
< "Q99L60-1","NP_598460.1","V-type proton ATPase subunit C 2 isoform 2","427",""
< "P97820-1","NP_032722.2","mitogen-activated protein kinase kinase kinase kinase 4 isoform 2","1234",""
8989a8971
> "Q6PB60-1","NP_001091692.1","protein BHLHb9","539",""
8993c8975
< "Q8K1E0-1","NP_062803.4","syntaxin-5","355",""
---
> "O54946-1","NP_001033029.1","dnaJ homolog subfamily B member 6 isoform a","365",""
8996,8997c8978,8981
< "Q9D902-1","NP_080860.3","general transcription factor IIE subunit 2","292",""
< "A2RSY1-1","NP_766240.1","KAT8 regulatory NSL complex subunit 3 isoform 2","877",""
---
> "Q9WU81-1","NP_001139432.1","glucose-6-phosphate exchanger SLC37A2 isoform 1","506",""
> "Q3UH06-1","NP_001034277.1","ras-responsive element-binding protein 1 isoform 1","1291",""
> "Q9D902-1","NP_001161393.1","general transcription factor IIE subunit 2","292",""
> "Q9Z104-1","NP_001156637.1","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related","317",""
9000d8983
< "Q9JHQ0-1","NP_076117.2","annexin A9","345",""
9006d8988
< "Q9WTT4-1","NP_075668.1","V-type proton ATPase subunit G 2 isoform 1","118",""
9010,9011c8992
< "Q3TUF7-1","NP_001139402.1","YEATS domain-containing protein 2 isoform 1","1407",""
< "Q6P253-1","NP_766487.3","dermokine isoform b precursor","508",""
---
> "Q69ZP3-1","NP_001034598.1","probable hydrolase PNKD isoform 3","385",""
9015d8995
< "Q9DBG3-1","NP_082191.1","AP-2 complex subunit beta isoform b","937",""
9017d8996
< "B7ZWI3-1","NP_001156644.1","transmembrane protein 92 isoform 1 precursor","162",""
9022a9002
> "Q91XA2-1","NP_001030294.1","Golgi membrane protein 1","393",""
9030d9009
< "Q80TC5-1","NP_780379.2","pogo transposable element with KRAB domain isoform 1","614",""
9035c9014
< "Q3UV71-1","NP_945318.2","protein O-mannosyl-transferase TMTC1 isoform 1","942",""
---
> "Q9DAK3-1","NP_001074816.1","rho-related BTB domain-containing protein 1 isoform 1","695",""
9041d9019
< "Q4VAA2-1","NP_787027.1","protein CDV3 isoform b","281",""
9044d9021
< "A2A6Q5-1","NP_663411.2","cell division cycle protein 27 homolog isoform 2","825",""
9046a9024,9025
> "Q61749-1","NP_001120827.1","translation initiation factor eIF-2B subunit delta isoform 1","544",""
> "Q8CJ40-1","NP_001139430.1","rootletin isoform 2","1845",""
9049d9027
< "Q148W8-1","NP_001153521.1","inactive dual specificity phosphatase 27","1138",""
9052c9030
< "Q812A5-1","NP_666173.4","proline-rich protein 5 isoform 1","387",""
---
> "Q9CZ30-1","NP_080218.1","obg-like ATPase 1 isoform a","396",""
9058a9037
> "P06801-1","NP_001185862.1","NADP-dependent malic enzyme isoform 2","552",""
9060,9062c9039
< "Q810F8-1","NP_035663.1","T-box transcription factor TBX10 isoform 2","344",""
< "Q9Z104-1","NP_034570.1","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related","317",""
< "A2ACP1-1","NP_700441.2","tetratricopeptide repeat protein 39A isoform 2","576",""
---
> "Q9WU03-1","NP_001076017.1","kunitz-type protease inhibitor 2 isoform b precursor","195",""
9066c9043
< "P20863-1","NP_032133.2","embryonic growth/differentiation factor 1 precursor","357","This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is translated from a monocistronic mRNA early in development, and from a bicistronic mRNA in later stages that also encodes ceramide synthase 1. [provided by RefSeq, Jul 2016]. "
---
> "Q9D358-1","NP_001103709.1","low molecular weight phosphotyrosine protein phosphatase isoform 1","158",""
9069d9045
< "Q9CZ30-1","NP_084367.1","obg-like ATPase 1 isoform b","270",""
9071a9048
> "Q9DBG3-1","NP_001030931.1","AP-2 complex subunit beta isoform a","951",""
9072a9050,9052
> "Q9JI75-1","NP_001156713.1","ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1","231",""
> "A2ACP1-1","NP_001139420.1","tetratricopeptide repeat protein 39A isoform 1","578",""
> "Q8CI52-1","NP_001165578.1","protein Aster-C isoform 1","457",""
9074d9053
< "Q9WU81-1","NP_064654.3","glucose-6-phosphate exchanger SLC37A2 isoform 2","501",""
9078d9056
< "Q07076-1","NP_033804.2","annexin A7","463",""
9080c9058
< "Q3UYK3-1","NP_082034.1","TBC1 domain family member 9 isoform 2","1031",""
---
> "Q05BQ1-1","NP_001139272.1","protein turtle homolog A precursor","1179",""
9085a9064
> "Q9JHQ0-1","NP_001078852.1","annexin A9","345",""
9087d9065
< "Q8VHI5-1","NP_083089.1","vitrin isoform 1 precursor","650",""
9091a9070
> "Q8BIQ3-1","NP_001104499.1","zinc finger protein 2 isoform a","427",""
9093d9071
< "Q91XA2-1","NP_081583.3","Golgi membrane protein 1","393",""
9096c9074,9078
< "Q9Z2X1-1","NP_598595.1","heterogeneous nuclear ribonucleoprotein F","415",""
---
> "Q9JMB1-1","NP_035713.1","testicular haploid expressed gene protein isoform 1","375",""
> "P23249-1","NP_001156912.1","putative helicase MOV-10 isoform a","1077",""
> "Q3TUF7-1","NP_001028409.2","YEATS domain-containing protein 2 isoform 2","1354",""
> "Q3UMR0-1","NP_663608.3","ankyrin repeat domain-containing protein 27 isoform 1","1048",""
> "Q8C0D0-1","NP_082391.1","probable tRNA pseudouridine synthase 1 isoform 1","338",""
9098d9079
< "Q8CJ40-1","NP_742120.2","rootletin isoform 1","2009",""
9100a9082
> "Q80TC5-1","NP_001136420.1","pogo transposable element with KRAB domain isoform 2","626",""
9103a9086
> "Q9QZ41-1","NP_001177646.1","protein DBF4 homolog A isoform 2","662",""
9105d9087
< "Q7TPM1-1","NP_766249.2","protein PRRC2B isoform 2","1486",""
9107,9108c9089
< "Q9JLK4-1","NP_038906.2","calcium-binding protein 2 isoform 1","221",""
< "Q61983-1","NP_033224.3","sodium-dependent phosphate transport protein 1","465",""
---
> "Q3UF64-1","NP_001103372.1","RING finger and transmembrane domain-containing protein 2 isoform 2","445",""
9111,9112d9091
< "Q9D358-1","NP_067305.2","low molecular weight phosphotyrosine protein phosphatase isoform 2","158",""
< "Q9JMA7-1","NP_059092.2","cytochrome P450 3A41","504",""
9119c9098
< "Q6PGB6-1","NP_082384.1","N-alpha-acetyltransferase 50 isoform 1","168",""
---
> "Q69ZB0-1","NP_001157051.1","leucine-rich repeat and coiled-coil domain-containing protein 1 isoform 1","1026",""
9122,9123d9100
< "Q61749-1","NP_034252.2","translation initiation factor eIF-2B subunit delta isoform 2","524",""
< "Q8CI52-1","NP_705756.1","protein Aster-C isoform 1","457",""
9124a9102,9105
> "Q8R1X6-1","NP_001138459.1","spartin isoform a","671",""
> "Q66JY2-3","NP_001074905.1","INO80 complex subunit D isoform 2","916",""
> "Q9JLK4-1","NP_001153724.1","calcium-binding protein 2 isoform 2","168",""
> "Q8R4V2-1","NP_001152848.1","dual specificity protein phosphatase 15 isoform 1","235",""
9128a9110
> "Q8CC88-1","NP_082182.1","von Willebrand factor A domain-containing protein 8 isoform 1 precursor","1905",""
9141c9123,9124
< "Q9QZ41-1","NP_038754.1","protein DBF4 homolog A isoform 1","663",""
---
> "Q7TPM1-1","NP_001153106.1","protein PRRC2B isoform 1","2230",""
> "Q61983-1","NP_001164109.1","sodium-dependent phosphate transport protein 1","465",""
9146d9128
< "Q64516-3","NP_997609.1","glycerol kinase isoform 2","553",""
9150a9133
> "Q3TKT4-1","NP_001167549.1","transcription activator BRG1 isoform 1","1617",""
9152,9153d9134
< "P51807-1","NP_033368.1","dynein light chain Tctex-type 1","113",""
< "Q8C0D0-1","NP_084115.2","probable tRNA pseudouridine synthase 1 isoform 2","247",""
9155c9136
< "Q9WV98-1","NP_038924.1","mitochondrial import inner membrane translocase subunit Tim9","89",""
---
> "Q99M87-1","NP_001128584.1","dnaJ homolog subfamily A member 3, mitochondrial isoform 2","453",""
9158d9138
< "P70210-1","NP_035696.3","transcriptional enhancer factor TEF-5 isoform 2","439","This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and thought to play a role in placental gene regulation and development. Alternative splicing, and alternate use of an upstream AUG translation initiation codon, and an in-frame downstream non-AUG (AUA) codon, results in 2 isoforms. [provided by RefSeq, Jul 2008]. "
9159a9140
> "Q3UYK3-1","NP_001104774.1","TBC1 domain family member 9 isoform 1","1264",""
9162d9142
< "P58771-1","NP_077745.2","tropomyosin alpha-1 chain isoform Tpm1.6cy","284",""
9165c9145
< "A2AMT1-1","NP_033881.2","filensin isoform b","663",""
---
> "Q2M3X8-1","NP_001005740.1","phosphatase and actin regulator 1 isoform 2","642",""
9167,9169c9147
< "Q6S5C2-1","NP_766117.2","N-acetylglucosamine-1-phosphotransferase subunit gamma isoform 1 precursor","307",""
< "Q69ZP3-1","NP_079856.2","probable hydrolase PNKD isoform 2","142",""
< "Q3TKT4-1","NP_035547.2","transcription activator BRG1 isoform 2","1614",""
---
> "P70210-1","NP_001091696.2","transcriptional enhancer factor TEF-5 isoform 1","465","This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and thought to play a role in placental gene regulation and development. Alternative splicing, and alternate use of an upstream AUG translation initiation codon, and an in-frame downstream non-AUG (AUA) codon, results in 2 isoforms. [provided by RefSeq, Jul 2008]. "
9173,9175d9150
< "Q60651-1","NP_034779.1","killer cell lectin-like receptor 4 isoform 1","260",""
< "Q60772-1","NP_031697.1","cyclin-dependent kinase 4 inhibitor C","168","The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase (cdk) inhibitors, and contains five ankyrin repeats. This protein interacts with both Cdk4 and Cdk6 to inhibit their kinase activities, and prevent their interactions with D-type cyclins, thereby negatively regulating cell division. This gene is differentially expressed in a variety of tissues, and is cell cycle regulated. Deletion of this gene can lead to tumor growth. Maximal expression is observed at the G2/M phase. Alternative splicing and promoter usage results in multiple transript variants. [provided by RefSeq, Aug 2014]. "
< "Q60928-1","NP_032142.1","glutathione hydrolase 1 proenzyme precursor","568","This gene encodes gamma-glutamyl transpeptidase, a plasmamembrane-associated enzyme that cleaves the peptide bond between gamma-glutamyl and cysteinyl glycine moieties of glutathione. The encoded protein is autocatalytically processed to generate an enzymatically active heterodimer comprised of heavy and light chains. Mice lacking the encoded protein grow slowly, develop cataracts and have elevated levels of glutathione in plasma and urine. Transgenic overexpression of the encoded protein in mice enhances osteoclastic bone resorption. The mutant alleles termed 'Dwarf grey' and 'Dwarf grey Bayer' in mice are associated with deletions in this gene. A gamma-glutamyl transpeptidase paralog is located adjacent to this gene. Alternative splicing results in multiple transcript variants. Additional transcripts using alternate promoters and differing in 5' UTRs have been described. [provided by RefSeq, Apr 2015]. "
9178,9179c9153
< "Q6A0A2-1","NP_766173.1","la-related protein 4B isoform 1","741",""
< "Q9JM95-1","NP_058669.1","alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform 1","333",""
---
> "O35457-1","NP_001289305.1","C-C chemokine receptor-like 2","360",""
9181,9182d9154
< "Q00420-1","NP_997552.1","GA-binding protein subunit beta-1 isoform a","382",""
< "P05132-1","NP_032880.1","cAMP-dependent protein kinase catalytic subunit alpha isoform 1","351","This gene encodes a member of the serine/threonine protein kinase family. The holoenzyme, protein kinase A (also known as cyclic-AMP dependent protein kinase), mediates cellular response to changes in cyclic-AMP levels. This gene encodes the alpha catalytic subunit of protein kinase A. Protein kinase A-mediated signaling is transduced via phosphorylation of target proteins, and is important for many cellular functions, including mammalian sperm maturation and motility. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Apr 2013]. "
9186c9158,9159
< "Q9QXA1-1","NP_851293.1","cysteine and histidine-rich protein 1 isoform 2","192",""
---
> "Q9CQC2-1","NP_001303994.1","colipase isoform 2 precursor","72","This gene encodes a member of the colipase family of coenzymes that is required for the optimal activity of pancreatic lipase. The encoded protein undergoes proteolytic processing to generate a mature polypeptide that binds to the lipase and prevents inhibition by bile acids. Over half of the mice lacking the encoded protein die within two weeks of birth while the remaining ones exhibit fat malabsorption and altered body weight regulation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]. "
> "Q8BGG6-1","NP_001241691.1","motile sperm domain-containing protein 3","235",""
9188,9189c9161,9165
< "Q8CIE2-1","NP_082877.2","zinc finger MIZ domain-containing protein 2 isoform 1","920",""
< "Q9D379-1","NP_034275.1","epoxide hydrolase 1 isoform 1 precursor","455",""
---
> "P63037-1","NP_001158143.1","dnaJ homolog subfamily A member 1","397","The protein encoded by this gene is a member of the DnaJ family, whose members act as cochaperones of heat shock protein 70. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. Mice deficient for this gene display reduced levels of activation&#8208;induced deaminase, an enzyme that deaminates deoxycytidine at the immunoglobulin genes during immune responses. In addition, mice lacking this gene exhibit severe defects in spermatogenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. "
> "P29351-1","NP_001071173.1","tyrosine-protein phosphatase non-receptor type 6 isoform b","597",""
> "P20863-1","NP_001156754.1","embryonic growth/differentiation factor 1 precursor","357","This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is translated from a monocistronic mRNA early in development, and from a bicistronic mRNA in later stages that also encodes ceramide synthase 1. [provided by RefSeq, Jul 2016]. "
> "Q0P5W1-1","NP_001272822.1","vacuolar protein sorting-associated protein 8 homolog isoform 1","1427",""
> "Q812A3-1","NP_001297450.1","ankyrin repeat domain-containing protein 23 isoform 2","192",""
9191a9168,9169
> "Q60772-1","NP_001288297.1","cyclin-dependent kinase 4 inhibitor C","168","The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase (cdk) inhibitors, and contains five ankyrin repeats. This protein interacts with both Cdk4 and Cdk6 to inhibit their kinase activities, and prevent their interactions with D-type cyclins, thereby negatively regulating cell division. This gene is differentially expressed in a variety of tissues, and is cell cycle regulated. Deletion of this gene can lead to tumor growth. Maximal expression is observed at the G2/M phase. Alternative splicing and promoter usage results in multiple transript variants. [provided by RefSeq, Aug 2014]. "
> "P38649-1","NP_001277373.1","histo-blood group ABO system transferase isoform b","287",""
9193,9194d9170
< "Q9JKX3-1","NP_056614.3","transferrin receptor protein 2","798",""
< "Q9DAK3-1","NP_001239566.1","rho-related BTB domain-containing protein 1 isoform 1","695",""
9195a9172
> "Q64514-1","NP_001297469.1","tripeptidyl-peptidase 2 isoform 2","1249",""
9196a9174
> "Q60778-1","NP_001293151.1","NF-kappa-B inhibitor beta","359","This gene encodes an inhibitor of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB). The encoded protein prevents NF-kappaB-mediated transcription activation by sequestering it in the cytosol. In response to signals that induce NF-kappaB, such as cytokines and growth factors, the encoded protein undergoes phosphorylation, triggering its rapid ubiquitination and proteasomal degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
9199d9176
< "Q60778-1","NP_035038.2","NF-kappa-B inhibitor beta","359","This gene encodes an inhibitor of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB). The encoded protein prevents NF-kappaB-mediated transcription activation by sequestering it in the cytosol. In response to signals that induce NF-kappaB, such as cytokines and growth factors, the encoded protein undergoes phosphorylation, triggering its rapid ubiquitination and proteasomal degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
9202,9204c9179
< "Q60605-1","NP_034990.1","myosin light polypeptide 6 isoform MLC3sm","151",""
< "Q8K402-1","NP_851836.2","T-box transcription factor TBX22 isoform 2","531",""
< "Q8BIQ5-1","NP_573459.1","cleavage stimulation factor subunit 2 isoform 1","580",""
---
> "P52194-1","NP_001316556.1","calmegin isoform 1 precursor","611","This gene belongs to the calreticulin family, which includes calreticulin, calnexin, and calmegin, and encodes a calcium-binding molecular chaperone specifically expressed in pachytene stage male germ cells. It is required for the proper folding of newly synthesized membrane proteins in the endoplasmic reticulum including those critical for sperm migration from the uterus into the oviduct and sperm adhesion to and penetration of the zona pellucida. This gene plays a key role in spermatogenesis and male infertility. Alternative splice variants exist for this gene. [provided by RefSeq, Jul 2016]. "
9206,9208c9181,9183
< "O08795-1","NP_032951.1","glucosidase 2 subunit beta isoform 2 precursor","521",""
< "Q8VCS0-1","NP_067294.2","N-acetylmuramoyl-L-alanine amidase isoform a precursor","530",""
< "P97450-1","NP_058035.1","ATP synthase-coupling factor 6, mitochondrial precursor","108","The protein encoded by this gene is a component of mitochondrial adenosine triphosphate synthase, which catalyzes the conversion of ATP from ADP. Mitochondrial adenosine triphosphate synthase consists of extrinsic and intrinsic membrane domains that are joined by a stalk. The protein encoded by this gene is a subunit of the stalk domain. A bi-directional promoter that drives expression of this gene has been has been identified. Pseudogenes of this gene are found on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
---
> "P40124-1","NP_001287996.1","adenylyl cyclase-associated protein 1","474","The product of this gene plays a role in regulating actin dynamics by binding actin monomers and promoting the turnover of actin filaments. Reduced expression of this gene causes a reduction in actin filament turnover rates, causing multiple defects, including an increase in cell size, stress-fiber alterations, and defects in endocytosis and cell motility. A pseudogene of this gene is found on chromosome 14. Alternative splicing results in multiple transcript variants, but does not affect the protein. [provided by RefSeq, Jul 2014]. "
> "P35276-1","NP_001311460.1","ras-related protein Rab-3D","219",""
> "Q9QXA1-1","NP_001263251.1","cysteine and histidine-rich protein 1 isoform 2","192",""
9210a9186
> "Q7TQK1-1","NP_001293132.1","integrator complex subunit 7 isoform 2","842",""
9211a9188
> "O35226-1","NP_001268946.1","26S proteasome non-ATPase regulatory subunit 4 isoform 1","379",""
9213c9190
< "Q91YY5-1","NP_570931.1","solute carrier organic anion transporter family member 1A5","670",""
---
> "A6X935-1","NP_001152771.1","inter alpha-trypsin inhibitor, heavy chain 4 isoform 2 precursor","941","This gene encodes a member of the inter-alpha trypsin inhibitor (IaI) family of plasma serine protease inhibitors with diverse functions as anti-apoptotic and matrix stabilizing molecules during development. This gene is predominantly expressed in the liver and the encoded protein was found to be a plasma kallikrein-sensitive glycoprotein. This gene is located in a cluster of related inter alpha trypsin inhibitor genes on chromosome 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]. "
9214a9192,9194
> "Q6PGB6-1","NP_001334168.1","N-alpha-acetyltransferase 50 isoform 2","169",""
> "P97820-1","NP_001239129.1","mitogen-activated protein kinase kinase kinase kinase 4 isoform 1","1288",""
> "E9Q5K9-1","NP_001334304.1","YTH domain-containing protein 1 isoform 2","728",""
9215a9196
> "A2A6Q5-1","NP_001272917.1","cell division cycle protein 27 homolog isoform 1","830",""
9217a9199
> "Q9D7Q1-1","NP_001271453.1","chitotriosidase-1 isoform 2 precursor","396",""
9219c9201
< "Q9CQ31-1","NP_081129.1","ankyrin repeat and SOCS box protein 11 isoform 2","294",""
---
> "Q00420-1","NP_001258396.1","GA-binding protein subunit beta-1 isoform a","382",""
9223,9224d9204
< "Q9CQC2-1","NP_079745.1","colipase isoform 1 preproprotein","113","This gene encodes a member of the colipase family of coenzymes that is required for the optimal activity of pancreatic lipase. The encoded protein undergoes proteolytic processing to generate a mature polypeptide that binds to the lipase and prevents inhibition by bile acids. Over half of the mice lacking the encoded protein die within two weeks of birth while the remaining ones exhibit fat malabsorption and altered body weight regulation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]. "
< "Q91ZT7-1","NP_536692.1","ankyrin repeat and SOCS box protein 10 isoform 1","467",""
9226c9206
< "Q0P5W1-1","NP_001272823.1","vacuolar protein sorting-associated protein 8 homolog isoform 2","1399",""
---
> "P97450-1","NP_001289142.1","ATP synthase-coupling factor 6, mitochondrial precursor","108","The protein encoded by this gene is a component of mitochondrial adenosine triphosphate synthase, which catalyzes the conversion of ATP from ADP. Mitochondrial adenosine triphosphate synthase consists of extrinsic and intrinsic membrane domains that are joined by a stalk. The protein encoded by this gene is a subunit of the stalk domain. A bi-directional promoter that drives expression of this gene has been has been identified. Pseudogenes of this gene are found on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
9228d9207
< "O35226-1","NP_032977.1","26S proteasome non-ATPase regulatory subunit 4 isoform 2","376",""
9229a9209
> "Q6ZPQ6-1","NP_001276401.1","membrane-associated phosphatidylinositol transfer protein 2 isoform 2","1335",""
9231c9211
< "Q80YR6-1","NP_001239424.1","DNA endonuclease RBBP8","893",""
---
> "Q812A5-1","NP_001333591.1","proline-rich protein 5 isoform 2","378",""
9234d9213
< "Q8CJG1-1","NP_700452.2","protein argonaute-1 isoform 1","857","This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]. "
9235a9215
> "Q8VCS0-1","NP_001258405.1","N-acetylmuramoyl-L-alanine amidase isoform a precursor","530",""
9237,9238c9217,9218
< "P52194-1","NP_034034.2","calmegin isoform 1 precursor","611","This gene belongs to the calreticulin family, which includes calreticulin, calnexin, and calmegin, and encodes a calcium-binding molecular chaperone specifically expressed in pachytene stage male germ cells. It is required for the proper folding of newly synthesized membrane proteins in the endoplasmic reticulum including those critical for sperm migration from the uterus into the oviduct and sperm adhesion to and penetration of the zona pellucida. This gene plays a key role in spermatogenesis and male infertility. Alternative splice variants exist for this gene. [provided by RefSeq, Jul 2016]. "
< "Q8R516-1","NP_660106.2","E3 ubiquitin-protein ligase MIB2 isoform 2","921",""
---
> "Q8R516-1","NP_001243037.2","E3 ubiquitin-protein ligase MIB2 isoform 2","921",""
> "Q91YY5-1","NP_001254636.1","solute carrier organic anion transporter family member 1A5","670",""
9240d9219
< "Q64151-1","NP_001291259.1","semaphorin-4C precursor","834","This gene encodes a member of the semaphorin family of proteins that have diverse functions in neuronal development, heart morphogenesis, vascular growth, tumor progression and immune cell regulation. Lack of the encoded protein in some mice causes exencephaly resulting in neonatal lethality. Mice that bypass exencephaly show no obvious behavioral defects but display distinct pigmentation defects. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]. "
9242c9221
< "P38649-1","NP_109643.3","histo-blood group ABO system transferase isoform a","332",""
---
> "Q91ZT7-1","NP_001297405.1","ankyrin repeat and SOCS box protein 10 isoform 2","452",""
9244c9223
< "P40124-1","NP_031624.2","adenylyl cyclase-associated protein 1","474","The product of this gene plays a role in regulating actin dynamics by binding actin monomers and promoting the turnover of actin filaments. Reduced expression of this gene causes a reduction in actin filament turnover rates, causing multiple defects, including an increase in cell size, stress-fiber alterations, and defects in endocytosis and cell motility. A pseudogene of this gene is found on chromosome 14. Alternative splicing results in multiple transcript variants, but does not affect the protein. [provided by RefSeq, Jul 2014]. "
---
> "Q64516-3","NP_001281069.1","glycerol kinase isoform 4","559",""
9246c9225,9227
< "Q9JL27-1","NP_061364.2","galactoside 2-alpha-L-fucosyltransferase 2","347","This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is involved in the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. Disruption of this gene results in altered glycosylation of gastric mucosa and uterine epithelia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]. "
---
> "Q8BIQ5-1","NP_001277328.1","cleavage stimulation factor subunit 2 isoform 3","510",""
> "A2AMT1-1","NP_001277990.1","filensin isoform a","669",""
> "Q8R0M8-1","NP_001297634.1","monocarboxylate transporter 5 isoform 2","468",""
9249,9252c9230
< "O35457-1","NP_059494.2","C-C chemokine receptor-like 2","360",""
< "A6X935-1","NP_061216.2","inter alpha-trypsin inhibitor, heavy chain 4 isoform 1 precursor","942","This gene encodes a member of the inter-alpha trypsin inhibitor (IaI) family of plasma serine protease inhibitors with diverse functions as anti-apoptotic and matrix stabilizing molecules during development. This gene is predominantly expressed in the liver and the encoded protein was found to be a plasma kallikrein-sensitive glycoprotein. This gene is located in a cluster of related inter alpha trypsin inhibitor genes on chromosome 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]. "
< "P29351-1","NP_038573.2","tyrosine-protein phosphatase non-receptor type 6 isoform a","595",""
< "Q6P9J9-1","NP_780553.2","anoctamin-6 isoform 2","911",""
---
> "Q9WTT4-1","NP_001334280.1","V-type proton ATPase subunit G 2 isoform 2","77",""
9255,9256d9232
< "P35276-1","NP_114080.2","ras-related protein Rab-3D","219",""
< "P63037-1","NP_032324.1","dnaJ homolog subfamily A member 1","397","The protein encoded by this gene is a member of the DnaJ family, whose members act as cochaperones of heat shock protein 70. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. Mice deficient for this gene display reduced levels of activation&#8208;induced deaminase, an enzyme that deaminates deoxycytidine at the immunoglobulin genes during immune responses. In addition, mice lacking this gene exhibit severe defects in spermatogenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. "
9258d9233
< "Q812A3-1","NP_705722.2","ankyrin repeat domain-containing protein 23 isoform 1","306",""
9260,9261c9235,9236
< "Q6ZPQ6-1","NP_035386.1","membrane-associated phosphatidylinositol transfer protein 2 isoform 1","1281",""
< "Q9D7Q1-1","NP_082255.1","chitotriosidase-1 isoform 1 precursor","464",""
---
> "Q3UV71-1","NP_001334447.1","protein O-mannosyl-transferase TMTC1 isoform 2","904",""
> "Q99M04-1","NP_001297541.1","lipoyl synthase, mitochondrial isoform 2","289",""
9263,9264c9238,9239
< "Q9JIL4-1","NP_067492.2","Na(+)/H(+) exchange regulatory cofactor NHE-RF3","519",""
< "Q8BGG6-1","NP_084313.1","motile sperm domain-containing protein 3","235",""
---
> "Q64151-1","NP_001119519.1","semaphorin-4C precursor","834","This gene encodes a member of the semaphorin family of proteins that have diverse functions in neuronal development, heart morphogenesis, vascular growth, tumor progression and immune cell regulation. Lack of the encoded protein in some mice causes exencephaly resulting in neonatal lethality. Mice that bypass exencephaly show no obvious behavioral defects but display distinct pigmentation defects. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]. "
> "Q8C031-1","NP_001276671.1","leucine-rich repeat-containing protein 4C precursor","640",""
9269d9243
< "Q0P5V9-1","NP_001161727.1","solute carrier family 45 member 4 isoform 2","591",""
9271d9244
< "Q99M04-1","NP_077791.1","lipoyl synthase, mitochondrial isoform 1 precursor","373",""
9272a9246
> "Q80YR6-1","NP_001074692.1","DNA endonuclease RBBP8","893",""
9273a9248
> "Q3UHD9-1","NP_001028435.1","arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform 1","1186","The protein encoded by this gene is a member of the centaurin GTPase family. This gene product regulates the activity of multiple kinases, including PI3K. Reduced expression of this gene results in multiple defects, including neural deficiencies, while increased expression of this gene has been observed in some tumors. Alternative splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]. "
9274a9250,9251
> "Q8VI63-1","NP_001334489.1","MOB kinase activator 2 isoform 2","150",""
> "Q9JM95-1","NP_001020481.1","alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform 2","299",""
9276,9277c9253,9259
< "Q9Z2W9-1","NP_058582.3","glutamate receptor 3 isoform a precursor","888","This gene encodes a multi-pass transmembrane protein that forms a homotetramer or heterotetramer in neuronal cells. The encoded protein is a ligand-gated ion channel that responds to the neurotransmitter L-glutamate to promote synaptic transmission. Deficiency of this gene leads to behavioral phenotypes. The transcript is subject to RNA editing at codon 769 (AGA->GGA; R->G). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]. "
< "Q7TQK1-1","NP_848747.4","integrator complex subunit 7 isoform 1","966",""
---
> "Q91XL9-1","NP_001239418.1","oxysterol-binding protein-related protein 1 isoform 2","558",""
> "Q9D4J3-1","NP_001334373.1","discoidin, CUB and LCCL domain-containing protein 1 isoform 2 precursor","432",""
> "Q6A0A2-1","NP_001298046.1","la-related protein 4B isoform 2","657",""
> "Q9CQ31-1","NP_001300666.1","ankyrin repeat and SOCS box protein 11 isoform 1","323",""
> "Q3TPJ7-1","NP_001292727.1","midnolin isoform 2","464","This gene encodes a protein that contains an ubiquitin-like domain. This protein may be involved in the regulation of brain development as inferred by its high expression level in the embryonic midbrain. This protein has been found to negatively regulate glucokinase activity and insulin secretion in pancreatic beta cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
> "Q9JIL4-1","NP_001139473.1","Na(+)/H(+) exchange regulatory cofactor NHE-RF3","519",""
> "Q9Z2W9-1","NP_001268858.1","glutamate receptor 3 isoform a precursor","888","This gene encodes a multi-pass transmembrane protein that forms a homotetramer or heterotetramer in neuronal cells. The encoded protein is a ligand-gated ion channel that responds to the neurotransmitter L-glutamate to promote synaptic transmission. Deficiency of this gene leads to behavioral phenotypes. The transcript is subject to RNA editing at codon 769 (AGA->GGA; R->G). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]. "
9279a9262
> "P05132-1","NP_001264827.1","cAMP-dependent protein kinase catalytic subunit alpha isoform 2","343","This gene encodes a member of the serine/threonine protein kinase family. The holoenzyme, protein kinase A (also known as cyclic-AMP dependent protein kinase), mediates cellular response to changes in cyclic-AMP levels. This gene encodes the alpha catalytic subunit of protein kinase A. Protein kinase A-mediated signaling is transduced via phosphorylation of target proteins, and is important for many cellular functions, including mammalian sperm maturation and motility. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Apr 2013]. "
9281c9264,9265
< "Q80SU7-1","NP_001229969.1","interferon-induced very large GTPase 1","2427",""
---
> "P19228-1","NP_001272944.1","alpha-S1-casein isoform b precursor","305",""
> "Q9JL27-1","NP_001258922.1","galactoside 2-alpha-L-fucosyltransferase 2","347","This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is involved in the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. Disruption of this gene results in altered glycosylation of gastric mucosa and uterine epithelia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]. "
9284d9267
< "Q8C031-1","NP_848840.3","leucine-rich repeat-containing protein 4C precursor","640",""
9286a9270,9271
> "O08795-1","NP_001280579.1","glucosidase 2 subunit beta isoform 1 precursor","528",""
> "Q9D379-1","NP_001299847.1","epoxide hydrolase 1 isoform 2 precursor","441",""
9287a9273,9274
> "Q8BYK6-1","NP_001139391.1","YTH domain-containing family protein 3 isoform 2","585",""
> "Q60651-1","NP_001239506.1","killer cell lectin-like receptor 4 isoform 2","263",""
9292,9293c9279,9281
< "P00688-1","NP_001153624.1","amylase 2a2 precursor","508",""
< "Q2M3X8-1","NP_001289565.1","phosphatase and actin regulator 1 isoform 5","557",""
---
> "Q80SU7-1","NP_001229968.1","interferon-induced very large GTPase 1","2427",""
> "Q9D385-1","NP_077153.1","ADP-ribosylation factor-like protein 2-binding protein isoform 1","163",""
> "A2RSY1-1","NP_001297442.1","KAT8 regulatory NSL complex subunit 3 isoform 1","903",""
9296d9283
< "Q8BYK6-1","NP_766265.3","YTH domain-containing family protein 3 isoform 1","596",""
9298d9284
< "Q3TPJ7-1","NP_067540.1","midnolin isoform 1","508","This gene encodes a protein that contains an ubiquitin-like domain. This protein may be involved in the regulation of brain development as inferred by its high expression level in the embryonic midbrain. This protein has been found to negatively regulate glucokinase activity and insulin secretion in pancreatic beta cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
9300c9286
< "Q9D4J3-1","NP_079981.2","discoidin, CUB and LCCL domain-containing protein 1 isoform 1 precursor","503",""
---
> "Q0P5V9-1","NP_001028391.2","solute carrier family 45 member 4 isoform 1","785",""
9302c9288
< "Q6P1H6-1","NP_082198.1","ankyrin repeat and LEM domain-containing protein 2 isoform 2","963",""
---
> "Q8K402-1","NP_001277676.1","T-box transcription factor TBX22 isoform 3","315",""
9303a9290
> "Q60928-1","NP_001292921.1","glutathione hydrolase 1 proenzyme precursor","568","This gene encodes gamma-glutamyl transpeptidase, a plasmamembrane-associated enzyme that cleaves the peptide bond between gamma-glutamyl and cysteinyl glycine moieties of glutathione. The encoded protein is autocatalytically processed to generate an enzymatically active heterodimer comprised of heavy and light chains. Mice lacking the encoded protein grow slowly, develop cataracts and have elevated levels of glutathione in plasma and urine. Transgenic overexpression of the encoded protein in mice enhances osteoclastic bone resorption. The mutant alleles termed 'Dwarf grey' and 'Dwarf grey Bayer' in mice are associated with deletions in this gene. A gamma-glutamyl transpeptidase paralog is located adjacent to this gene. Alternative splicing results in multiple transcript variants. Additional transcripts using alternate promoters and differing in 5' UTRs have been described. [provided by RefSeq, Apr 2015]. "
9305d9291
< "Q8CBW3-1","NP_031406.2","abl interactor 1 isoform 3","475",""
9307c9293
< "P19228-1","NP_031810.1","alpha-S1-casein isoform a precursor","313",""
---
> "Q562D6-1","NP_001334024.1","tRNA (adenine(37)-N6)-methyltransferase isoform 2","431",""
9309d9294
< "Q91XL9-1","NP_997413.2","oxysterol-binding protein-related protein 1 isoform 1","950",""
9312a9298,9299
> "Q6GSS7-1","NP_038577.1","histone H2A type 2-A","130","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Oct 2015]. "
> "Q8VIK3-1","NP_001333631.1","histone H1oo isoform 2","246","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes and the encoded protein is expressed only in oocytes. [provided by RefSeq, Oct 2015]. "
9333d9319
< "Q8VIK3-1","NP_612184.1","histone H1oo isoform 1","304","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes and the encoded protein is expressed only in oocytes. [provided by RefSeq, Oct 2015]. "
9338d9323
< "Q9QZQ8-1","NP_036145.1","core histone macro-H2A.1 isoform 1","372","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015]. "
9341d9325
< "C0HKE7-1","NP_835496.1","histone H2A type 1-C","130","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. "
9343d9326
< "P10853-1","NP_835508.1","histone H2B type 1-F/J/L","126","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. "
9350d9332
< "Q6GSS7-1","NP_835584.1","histone H2A type 2-A","130","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]. "
9355d9336
< "O08785-1","NP_031741.1","circadian locomoter output cycles protein kaput isoform 1","855","The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with Arntl (Bmal1) that binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Polymorphisms in this gene may be associated with behavioral changes, obesity, and metabolic syndrome. Two transcripts encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]. "
9357a9339
> "Q5SRY7-1","NP_001258276.1","F-box/WD repeat-containing protein 11 isoform b","542",""
9360d9341
< "P05063-1","NP_033787.2","fructose-bisphosphate aldolase C","363","This gene encodes a member of the aldolase family of enzymes that is mainly expressed in neuronal tissues. The encoded protein is an enzyme of the glycolysis pathway, and catalyzes the conversion of fructose-1,6-bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]. "
9364c9345
< "Q60668-1","NP_031542.2","heterogeneous nuclear ribonucleoprotein D0 isoform c","306",""
---
> "Q6PGB8-1","NP_001277637.1","probable global transcription activator SNF2L1 isoform 2","1062",""
9366d9346
< "Q7TSK3-1","NP_067518.2","protocadherin-8 isoform 1 precursor","1070","This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a type I transmembrane protein composed of an extracellular domain including 6 cadherin ectodomains, a single-pass transmembrane domain and a cytoplasmic tail. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons with the first large exon encoding the extracellular and transmembrane region. Although this gene product is capable of homophilic interaction, it appears to affect cell-cell adhesion indirectly by initiating signaling events that regulate classical cadherin-mediated adhesion. Based on studies on this protein and its orthologs, this protocadherin mainly functions in developing embryos and the central nervous system, but can also function as a tumor suppressor. Alternative splicing yielding isoforms with unique cytoplasmic tails has been reported. [provided by RefSeq, Sep 2009]. "
9368d9347
< "P55264-1","NP_598840.1","adenosine kinase isoform 1","361",""
9372d9350
< "O54910-1","NP_032716.2","NF-kappa-B inhibitor epsilon isoform 1","364",""
9374d9351
< "Q8BKH7-1","NP_796319.1","target of rapamycin complex 2 subunit MAPKAP1 isoform a","522",""
9375a9353
> "P05063-1","NP_001290352.1","fructose-bisphosphate aldolase C","363","This gene encodes a member of the aldolase family of enzymes that is mainly expressed in neuronal tissues. The encoded protein is an enzyme of the glycolysis pathway, and catalyzes the conversion of fructose-1,6-bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]. "
9378d9355
< "Q9CZW6-1","NP_080794.2","E3 ubiquitin-protein ligase RNF146","359",""
9384d9360
< "Q8R0M8-1","NP_666248.1","monocarboxylate transporter 5 isoform 1","500",""
9388d9363
< "Q6PGB8-1","NP_444353.3","probable global transcription activator SNF2L1 isoform 1","1046",""
9392d9366
< "Q8K4C2-3","NP_849273.1","interleukin-17 receptor C isoform 1 precursor","698",""
9395c9369
< "E9Q5K9-1","NP_808348.2","YTH domain-containing protein 1 isoform 1","736",""
---
> "Q8BKH7-1","NP_001277554.1","target of rapamycin complex 2 subunit MAPKAP1 isoform a","522",""
9398d9371
< "P19785-1","NP_031982.1","estrogen receptor isoform 1","599","This gene encodes an estrogen receptor, a member of the nuclear hormone family of intracellular receptors. The encoded protein, activated by the sex hormone estrogen, is a transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Similar genes in human have been implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
9409a9383
> "P19785-1","NP_001289460.1","estrogen receptor isoform 1","599","This gene encodes an estrogen receptor, a member of the nuclear hormone family of intracellular receptors. The encoded protein, activated by the sex hormone estrogen, is a transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Similar genes in human have been implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
9414,9416c9388,9392
< "O35566-1","NP_033972.2","CD151 antigen","253",""
< "Q5SRY7-1","NP_598776.1","F-box/WD repeat-containing protein 11 isoform a","563",""
< "Q00731-1","NP_033531.3","vascular endothelial growth factor A isoform 2","368","This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.[provided by RefSeq, Nov 2015]. "
---
> "Q8K4C2-3","NP_598920.3","interleukin-17 receptor C isoform 2 precursor","674",""
> "Q60668-1","NP_001070733.1","heterogeneous nuclear ribonucleoprotein D0 isoform a","355",""
> "Q684R7-1","NP_001185740.1","FRAS1-related extracellular matrix protein 1 isoform 2 precursor","2172",""
> "Q7TSK3-1","NP_001036191.1","protocadherin-8 isoform 2 precursor","973","This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a type I transmembrane protein composed of an extracellular domain including 6 cadherin ectodomains, a single-pass transmembrane domain and a cytoplasmic tail. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons with the first large exon encoding the extracellular and transmembrane region. Although this gene product is capable of homophilic interaction, it appears to affect cell-cell adhesion indirectly by initiating signaling events that regulate classical cadherin-mediated adhesion. Based on studies on this protein and its orthologs, this protocadherin mainly functions in developing embryos and the central nervous system, but can also function as a tumor suppressor. Alternative splicing yielding isoforms with unique cytoplasmic tails has been reported. [provided by RefSeq, Sep 2009]. "
> "Q9CZW6-1","NP_001103666.1","E3 ubiquitin-protein ligase RNF146","359",""
9418d9393
< "B1AT66-1","NP_598799.1","monocarboxylate transporter 7 isoform b","523",""
9422,9423d9396
< "Q684R7-1","NP_808531.2","FRAS1-related extracellular matrix protein 1 isoform 1 precursor","2191",""
< "Q9JIM3-1","NP_075996.2","DNA excision repair protein ERCC-6-like 2 isoform 2","699",""
9424a9398
> "O35566-1","NP_001104519.1","CD151 antigen","253",""
9426d9399
< "Q9ESV0-1","NP_065240.2","ATP-dependent RNA helicase DDX24 isoform 2","857",""
9427a9401
> "O08785-1","NP_001276755.1","circadian locomoter output cycles protein kaput isoform 1","855","The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with Arntl (Bmal1) that binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Polymorphisms in this gene may be associated with behavioral changes, obesity, and metabolic syndrome. Two transcripts encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]. "
9432a9407
> "B1AT66-1","NP_001025013.1","monocarboxylate transporter 7 isoform a","607",""
9594d9568
< "Q7TSY6-1","NP_573458.2","CUGBP Elav-like family member 4 isoform 38","484",""
9597,9598c9571
< "P63137-1","NP_032096.1","gamma-aminobutyric acid receptor subunit beta-2 isoform 2 precursor","474",""
< "Q14AI6-1","NP_001333440.1","mitochondrial mRNA pseudouridine synthase Rpusd3 isoform 2","279",""
---
> "Q14AI6-1","NP_001028376.1","mitochondrial mRNA pseudouridine synthase Rpusd3 isoform 1","344",""
9605d9577
< "Q149I8-1","NP_082220.1","IQ domain-containing protein M","489",""
9609c9581
< "E9Q2S7-1","NP_001128491.1","zinc finger protein 561","604",""
---
> "E9PUQ3-1","NP_001128374.1","uncharacterized protein NKAPD1","292",""
9613a9586
> "E9Q2S7-1","NP_001075954.1","zinc finger protein 561","604",""
9617d9589
< "E9Q137-1","NP_035703.2","testis-expressed protein 264","309",""
9626d9597
< "E9PUQ3-1","NP_997614.2","uncharacterized protein NKAPD1","292",""
9627a9599,9600
> "E9Q137-1","NP_001075123.1","testis-expressed protein 264","309",""
> "Q149I8-1","NP_001157707.1","IQ domain-containing protein M","489",""
9632c9605,9607
< "Q8BJM7-1","NP_849228.1","S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 isoform 2","454",""
---
> "Q80XM9-1","NP_001157892.1","solute carrier family 66 member 2 isoform b","253",""
> "Q9D8B1-1","NP_001334291.1","androgen-induced gene 1 protein isoform 2","238",""
> "Q9Z321-1","NP_001313505.1","DNA topoisomerase 3-beta-1","862",""
9635d9609
< "Q14DH7-1","NP_941038.2","acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 2","497",""
9637a9612,9615
> "Q9CZW4-1","NP_001028778.2","long-chain-fatty-acid--CoA ligase 3 isoform a","720",""
> "Q924Z4-1","NP_001307421.1","ceramide synthase 2","380",""
> "Q3UNX5-1","NP_058566.3","acyl-coenzyme A synthetase ACSM3, mitochondrial","580",""
> "Q9QUJ7-1","NP_001028772.1","long-chain-fatty-acid--CoA ligase 4 isoform 2","670",""
9639,9640d9616
< "Q924Z4-1","NP_084065.1","ceramide synthase 2","380",""
< "Q6E1M8-1","NP_808414.2","acyl-CoA wax alcohol acyltransferase 2 isoform 1","333",""
9644d9619
< "P41216-1","NP_032007.2","long-chain-fatty-acid--CoA ligase 1","699","The protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is expressed in monocytes and macrophages where it appears to have a functionally distinct role in mediating inflammatory and innate immune responses. A pseudogene of this gene is found on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
9646d9620
< "Q9D8B1-1","NP_079722.1","androgen-induced gene 1 protein isoform 1","262",""
9648a9623,9624
> "B1ATX6-1","NP_001156576.1","terminal nucleotidyltransferase 5D","390",""
> "Q14DH7-1","NP_001136276.1","acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 1","682",""
9651,9653c9627,9629
< "Q8CIC2-1","NP_694732.3","nucleoporin NUP42 isoform 1","420",""
< "B1ATX6-1","NP_001257937.1","terminal nucleotidyltransferase 5D","390",""
< "Q8C138-1","NP_780626.1","androgen-dependent TFPI-regulating protein isoform 1","262",""
---
> "Q7TT16-1","NP_001334120.1","inositol polyphosphate multikinase isoform 2","397",""
> "P41216-1","NP_001289092.1","long-chain-fatty-acid--CoA ligase 1","699","The protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is expressed in monocytes and macrophages where it appears to have a functionally distinct role in mediating inflammatory and innate immune responses. A pseudogene of this gene is found on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
> "Q8CIC2-1","NP_001333511.1","nucleoporin NUP42 isoform 2","224",""
9655d9630
< "Q9D142-1","NP_079675.1","uridine diphosphate glucose pyrophosphatase NUDT14 isoform 1","222",""
9658,9660d9632
< "Q9CZW4-1","NP_083093.2","long-chain-fatty-acid--CoA ligase 3 isoform a","720",""
< "Q8K0L3-1","NP_666309.1","acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 3","575",""
< "Q3UNX5-1","NP_997607.2","acyl-coenzyme A synthetase ACSM3, mitochondrial","580",""
9661a9634
> "Q8BJM7-1","NP_001015876.1","S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 isoform 1","721",""
9663d9635
< "Q80XM9-1","NP_080137.2","solute carrier family 66 member 2 isoform a","271",""
9665d9636
< "Q7TT16-1","NP_081460.1","inositol polyphosphate multikinase isoform 1","396",""
9670c9641
< "Q9Z321-1","NP_035754.1","DNA topoisomerase 3-beta-1","862",""
---
> "Q8K0L3-1","NP_001171448.1","acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 1","600",""
9672c9643,9644
< "Q9QUJ7-1","NP_997508.1","long-chain-fatty-acid--CoA ligase 4 isoform 1","711",""
---
> "Q8C138-1","NP_001139347.1","androgen-dependent TFPI-regulating protein isoform 2","230",""
> "Q6E1M8-1","NP_001277324.1","acyl-CoA wax alcohol acyltransferase 2 isoform 2","282",""
9674d9645
< "Q62234-1","NP_034997.2","myomesin-1 isoform 1","1667",""
9679a9651
> "Q62234-1","NP_001077403.1","myomesin-1 isoform 2","1569",""
9686d9657
< "D3YX03-1","NP_001170997.1","predicted gene 7861 precursor","116",""
9693a9665
> "A2BED8-1","NP_001188287.1","uncharacterized protein LOC667256","237",""
9698a9671
> "D3YX03-1","NP_001170989.1","predicted gene, EG665927 precursor","116",""
9700a9674
> "Q8BR63-1","NP_001093586.1","protein FAM177A1","207",""
9703,9705d9676
< "Q9QXS6-1","NP_062787.2","drebrin isoform 3","660",""
< "Q8BJ05-1","NP_083610.2","zinc finger CCCH domain-containing protein 14 isoform a","735",""
< "Q7TSH3-1","NP_898854.1","zinc finger protein 516","1157",""
9707c9678,9679
< "Q7TN75-1","NP_570947.2","retrotransposon-derived protein PEG10 isoform 1","1006","This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation, apoptosis and cancer development. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. [provided by RefSeq, Oct 2014]. "
---
> "Q8CJ12-1","NP_001073317.1","adhesion G-protein coupled receptor G2 isoform 4","982",""
> "Q9QXS6-1","NP_001170842.1","drebrin isoform 1","706",""
9710a9683
> "Q8CHY7-1","NP_001161947.1","tetratricopeptide repeat protein 23 isoform 2","446",""
9712,9713d9684
< "Q8CE90-1","NP_036074.2","dual specificity mitogen-activated protein kinase kinase 7 isoform 2","419",""
< "Q8CHY7-1","NP_080181.2","tetratricopeptide repeat protein 23 isoform 1","488",""
9716d9686
< "Q8CJ12-1","NP_848827.1","adhesion G-protein coupled receptor G2 isoform 1 precursor","1009",""
9717a9688
> "Q8CE90-1","NP_001036022.1","dual specificity mitogen-activated protein kinase kinase 7 isoform 1","468",""
9719a9691
> "P70270-1","NP_001116430.1","DNA repair and recombination protein RAD54-like","747",""
9722c9694,9695
< "Q8CBC7-1","NP_001277359.1","putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform 2","322",""
---
> "O35144-1","NP_001076587.1","telomeric repeat-binding factor 2 isoform 2","470",""
> "Q7TSH3-1","NP_001170935.1","zinc finger protein 516","1157",""
9726c9699,9700
< "Q7TS63-1","NP_941046.1","zinc finger protein ZFAT isoform 2","1219",""
---
> "Q3TDN0-1","NP_001265147.1","protein dispatched homolog 1","1521",""
> "Q3U0X6-1","NP_001028471.1","zinc finger protein 217","1041",""
9727a9702,9703
> "P0DP26-1","NP_001300863.1","calmodulin-1 isoform 1","197","This gene encodes a member of the EF-hand calcium-binding protein family. The encoded protein acts as a calcium sensor and is involved in relaying signals to calcium-sensitive proteins, enzymes and ion channels. The protein-calcium complex binds target proteins to regulate several cellular processes, including smooth muscle contraction, inflammation, apoptosis and the immune response. Mutations in the human gene are associated with catecholaminergic polymorphic ventricular tachycardia and long QT syndrome 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. "
> "P20693-1","NP_001240666.1","low affinity immunoglobulin epsilon Fc receptor isoform B","330",""
9729d9704
< "Q9WUA3-1","NP_062677.1","ATP-dependent 6-phosphofructokinase, platelet type isoform 1","784",""
9730a9706
> "Q9JHF9-1","NP_001153183.1","lymphocyte antigen 96 isoform B precursor","142",""
9739,9741d9714
< "Q80TS3-1","NP_941991.1","adhesion G protein-coupled receptor L3 isoform 1 precursor","1543",""
< "Q3TDN0-1","NP_081142.3","protein dispatched homolog 1","1521",""
< "P20693-1","NP_038545.1","low affinity immunoglobulin epsilon Fc receptor isoform A","331",""
9746d9718
< "Q99KY4-1","NP_705797.1","cyclin-G-associated kinase isoform 1","1305",""
9747a9720,9721
> "Q8CBC7-1","NP_598752.2","putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform 1","324",""
> "Q8BJ05-1","NP_001008506.2","zinc finger CCCH domain-containing protein 14 isoform b","604",""
9749,9751c9723,9725
< "Q8R0X7-1","NP_033189.2","sphingosine-1-phosphate lyase 1","568",""
< "O35144-1","NP_001273129.1","telomeric repeat-binding factor 2 isoform 3","476",""
< "P0DP28-1","NP_033920.1","calmodulin-1 isoform 2","149","This gene encodes a member of the EF-hand calcium-binding protein family. The encoded protein acts as a calcium sensor and is involved in relaying signals to calcium-sensitive proteins, enzymes and ion channels. The protein-calcium complex binds target proteins to regulate several cellular processes, including smooth muscle contraction, inflammation, apoptosis and the immune response. Mutations in the human gene are associated with catecholaminergic polymorphic ventricular tachycardia and long QT syndrome 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. "
---
> "Q99KY4-1","NP_001268980.1","cyclin-G-associated kinase isoform 2","1144",""
> "Q8BG99-1","NP_001025009.1","homeobox protein PKNOX2","474",""
> "Q8R0X7-1","NP_001303602.1","sphingosine-1-phosphate lyase 1","568",""
9752a9727
> "P26043-1","NP_001098086.1","radixin isoform a","583",""
9754,9755c9729
< "Q8BGW5-1","NP_082972.2","SOSS complex subunit B2 isoform a","198",""
< "Q9ERA0-1","NP_258437.1","alpha-globin transcription factor CP2 isoform 1","502",""
---
> "Q7TN75-1","NP_001035701.1","retrotransposon-derived protein PEG10 isoform 2","376","This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation, apoptosis and cancer development. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. [provided by RefSeq, Oct 2014]. "
9757a9732
> "Q9WUA3-1","NP_001278000.1","ATP-dependent 6-phosphofructokinase, platelet type isoform 2","784",""
9762,9763d9736
< "Q8BG99-1","NP_683752.2","homeobox protein PKNOX2","474",""
< "Q3U0X6-1","NP_001153155.1","zinc finger protein 217","1041",""
9770c9743
< "P70270-1","NP_033041.3","DNA repair and recombination protein RAD54-like","747",""
---
> "Q80TS3-1","NP_001334298.1","adhesion G protein-coupled receptor L3 isoform 4 precursor","1528",""
9772d9744
< "P26043-1","NP_033067.2","radixin isoform a","583",""
9775a9748
> "Q8BGW5-1","NP_001297477.1","SOSS complex subunit B2 isoform b","118",""
9777d9749
< "Q9JHF9-1","NP_058619.1","lymphocyte antigen 96 isoform A precursor","160",""
9781d9752
< "O08523-1","NP_033373.2","alpha-tectorin isoform 1 preproprotein","2155",""
9785d9755
< "Q80UW0-1","NP_056634.3","heparan-sulfate 6-O-sulfotransferase 2 isoform 2 precursor","466",""
9791c9761
< "Q8R0S4-3","NP_666235.1","voltage-dependent L-type calcium channel subunit beta-4 isoform b","486",""
---
> "Q8R0S4-3","NP_001032176.1","voltage-dependent L-type calcium channel subunit beta-4 isoform a","519",""
9794d9763
< "P52479-1","NP_033488.1","ubiquitin carboxyl-terminal hydrolase 10 isoform 1","793",""
9795a9765
> "Q80X50-1","NP_001159455.1","ubiquitin-associated protein 2-like isoform 3","1112",""
9797,9798d9766
< "Q9JL15-1","NP_061374.1","galectin-8 isoform 1","316",""
< "Q07475-1","NP_444308.1","neuronal regeneration-related protein","68",""
9801,9804c9769
< "Q99K82-1","NP_663508.1","spermine oxidase isoform b","555",""
< "Q9Z172-1","NP_064313.1","small ubiquitin-related modifier 3 isoform 1 precursor","110","This gene encodes a member of the small ubiquitin-like modifier family. The encoded protein may regulate a variety of proteins in many pathways via a post-translational modification, known as SUMOylation. This activity may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Disruption of some of these processes has been associated with cerebral ischemia, neural dysfunction, and heart disease. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. "
< "Q8BZN6-1","NP_780500.2","dedicator of cytokinesis protein 10 isoform 1","2187",""
< "Q99N50-1","NP_113571.2","synaptotagmin-like protein 2 isoform 3","910",""
---
> "Q99NH8-1","NP_001259007.1","triggering receptor expressed on myeloid cells 2 isoform 2 precursor","249","The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]. "
9805a9771,9774
> "P54763-3","NP_001277682.1","ephrin type-B receptor 2 isoform 1 precursor","987","This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors consist of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. The encoded receptor preferentially binds membrane-bound ephrin-B ligands and is involved in nervous system and vascular development. This gene is used as a marker of intestinal stem cells. Homozygous knockout mice for this gene exhibit impaired axon guidance and vestibular function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. "
> "Q8BHB0-1","NP_001164478.1","nucleotide-binding oligomerization domain-containing protein 1","953",""
> "Q8CEC5-1","NP_001303640.1","NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2","162",""
> "P04925-1","NP_001265185.1","major prion protein precursor","254",""
9808d9776
< "Q8CEC5-1","NP_076015.2","NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1","192",""
9810a9779
> "P39429-1","NP_001277342.1","TNF receptor-associated factor 2 isoform a","508",""
9814a9784,9785
> "Q99N50-1","NP_001035174.1","synaptotagmin-like protein 2 isoform 2","934",""
> "Q08024-1","NP_001154928.1","core-binding factor subunit beta isoform 2","148",""
9816d9786
< "Q9JHL1-1","NP_075938.2","Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform B","226",""
9818a9789
> "Q9ERE3-1","NP_001032848.1","serine/threonine-protein kinase Sgk3","496",""
9819a9791
> "Q76LS9-1","NP_598619.2","ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 2","459",""
9824d9795
< "Q80X50-1","NP_082751.1","ubiquitin-associated protein 2-like isoform 1","1105",""
9825a9797
> "Q920Q8-1","NP_001034600.1","influenza virus NS1A-binding protein homolog isoform 1","221",""
9827a9800,9801
> "Q8BJS4-1","NP_001192274.1","SUN domain-containing protein 2 isoform 1","731",""
> "P49817-1","NP_001229993.1","caveolin-1 isoform 2","147",""
9830d9803
< "Q8VI36-1","NP_598676.2","paxillin isoform beta","591",""
9832a9806
> "Q61036-1","NP_001181977.1","serine/threonine-protein kinase PAK 3 isoform C","559",""
9835,9836d9808
< "P39429-1","NP_033448.2","TNF receptor-associated factor 2 isoform b","501",""
< "Q9ERE3-1","NP_808215.2","serine/threonine-protein kinase Sgk3","496",""
9838d9809
< "Q99NH8-1","NP_112544.1","triggering receptor expressed on myeloid cells 2 isoform 1 precursor","227","The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]. "
9842,9843d9812
< "Q08024-1","NP_071704.3","core-binding factor subunit beta isoform 1","187",""
< "P54763-3","NP_034272.1","ephrin type-B receptor 2 isoform 2 precursor","986","This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors consist of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. The encoded receptor preferentially binds membrane-bound ephrin-B ligands and is involved in nervous system and vascular development. This gene is used as a marker of intestinal stem cells. Homozygous knockout mice for this gene exhibit impaired axon guidance and vestibular function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. "
9844a9814
> "P47757-1","NP_001032850.1","F-actin-capping protein subunit beta isoform a","277","This gene encodes the beta subunit of a highly conserved filamentous actin capping protein that binds the barbed end of filamentous actin to stabilize it and terminate elongation. Interaction of this protein with the barbed end of the actin filament occurs through binding of the amphipathic helix at the C-terminus to the hydrophobic cleft on the actin molecule. This gene is required for a variety of dynamic actin-mediated processes including organization of lamellipodia and filopodia, growth cone morphology and neurite outgrowth in hippocampal neurons, and asymmetric spindle migration and polar body extrusion during oocyte maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. "
9848d9817
< "Q61036-1","NP_032804.2","serine/threonine-protein kinase PAK 3 isoform D","544",""
9851,9852d9819
< "P04925-1","NP_035300.1","major prion protein precursor","254",""
< "Q9EP97-1","NP_109627.3","sentrin-specific protease 3","568",""
9854c9821
< "Q9QWY8-1","NP_034156.2","arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform a","1147",""
---
> "Q9Z172-1","NP_001288600.1","small ubiquitin-related modifier 3 isoform 2","110","This gene encodes a member of the small ubiquitin-like modifier family. The encoded protein may regulate a variety of proteins in many pathways via a post-translational modification, known as SUMOylation. This activity may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Disruption of some of these processes has been associated with cerebral ischemia, neural dysfunction, and heart disease. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. "
9855a9823
> "Q60631-1","NP_001300865.1","growth factor receptor-bound protein 2","217","The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]. "
9857d9824
< "Q8BHB0-1","NP_766317.1","nucleotide-binding oligomerization domain-containing protein 1","953",""
9862,9863c9829
< "Q76LS9-1","NP_955769.1","ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 1","468",""
< "O54709-1","NP_149069.1","NKG2-D type II integral membrane protein isoform a","232",""
---
> "Q9EP97-1","NP_001157043.1","sentrin-specific protease 3","568",""
9868d9833
< "Q60631-1","NP_032189.1","growth factor receptor-bound protein 2","217","The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]. "
9869a9835
> "Q9DBD2-1","NP_001289312.1","E3 ubiquitin-protein ligase MARCH8 isoform 1","286","The protein encoded by this gene is a member of the membrane-associated really interesting new gene-CH family of proteins. These proteins are E3 ubiquitin-protein ligases that modulate antigen presentation by downregulating major histocompatibility complex class II surface expression through endocytosis. The transcript is primarily expressed by dendritic cells and macrophages. Overexpression of this gene in antigen presenting cells results in immune defective phenotypes, including resistance to autoimmune disease onset. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
9873,9874c9839,9841
< "Q8BJS4-1","NP_919323.2","SUN domain-containing protein 2 isoform 3","699",""
< "Q9ES90-1","NP_071715.3","G-protein coupled receptor 35","307",""
---
> "Q8VI36-1","NP_035353.1","paxillin isoform alpha","557",""
> "Q9ES90-1","NP_001097999.1","G-protein coupled receptor 35","307",""
> "Q9WTN0-1","NP_001318048.1","geranylgeranyl pyrophosphate synthase isoform 1","300",""
9877c9844,9847
< "Q920Q8-1","NP_473443.2","influenza virus NS1A-binding protein homolog isoform 2","642",""
---
> "Q99K82-1","NP_001171304.1","spermine oxidase isoform a","585",""
> "P52479-1","NP_001297559.1","ubiquitin carboxyl-terminal hydrolase 10 isoform 2","792",""
> "Q07475-1","NP_001103458.1","neuronal regeneration-related protein","68",""
> "Q9QWY8-1","NP_001263390.1","arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform b","1087",""
9879c9849
< "P47757-1","NP_033928.1","F-actin-capping protein subunit beta isoform b","272","This gene encodes the beta subunit of a highly conserved filamentous actin capping protein that binds the barbed end of filamentous actin to stabilize it and terminate elongation. Interaction of this protein with the barbed end of the actin filament occurs through binding of the amphipathic helix at the C-terminus to the hydrophobic cleft on the actin molecule. This gene is required for a variety of dynamic actin-mediated processes including organization of lamellipodia and filopodia, growth cone morphology and neurite outgrowth in hippocampal neurons, and asymmetric spindle migration and polar body extrusion during oocyte maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. "
---
> "Q9JHL1-1","NP_075542.2","Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform A","337",""
9884,9885c9854
< "Q80YE7-1","NP_598823.1","death-associated protein kinase 1 isoform 1","1430",""
< "Q9DBD2-1","NP_082196.1","E3 ubiquitin-protein ligase MARCH8 isoform 1","286","The protein encoded by this gene is a member of the membrane-associated really interesting new gene-CH family of proteins. These proteins are E3 ubiquitin-protein ligases that modulate antigen presentation by downregulating major histocompatibility complex class II surface expression through endocytosis. The transcript is primarily expressed by dendritic cells and macrophages. Overexpression of this gene in antigen presenting cells results in immune defective phenotypes, including resistance to autoimmune disease onset. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
---
> "Q9JL15-1","NP_001185972.1","galectin-8 isoform 1","316",""
9887a9857,9859
> "Q14AT2-1","NP_001161469.1","testis-expressed protein 11 isoform 2","707",""
> "O54709-1","NP_001076791.1","NKG2-D type II integral membrane protein isoform b","219",""
> "Q8BZN6-1","NP_001272856.1","dedicator of cytokinesis protein 10 isoform 2","2175",""
9889,9890d9860
< "Q8K480-1","NP_667337.1","membrane frizzled-related protein isoform 1","584","The protein encoded by this gene contains a region with similarity to the cysteine-rich domain (CRD) of frizzled, a gene originally found in Drosophila that controls tissue polarity. This protein functions in eye development, where it is necessary for the maintenance of photoreceptor outer segments. Mutations in this gene cause retinal degeneration 6 in mice, which gives rise to a mouse model for human retinitis punctata albescens. Bicistronic transcripts composed of the coding sequences for this gene (Mfrp) and the C1q and tumor necrosis factor related protein 5 gene (C1qtnf5) have been identified, and the resulting products can interact with each other. Co-transcription of C1qtnf5 and Mfrp has been observed in both human and mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]. "
< "P49817-1","NP_031642.1","caveolin-1 isoform 1","178",""
9894d9863
< "Q14AT2-1","NP_113561.2","testis-expressed protein 11 isoform 1","947",""
9896d9864
< "P56473-1","NP_031453.1","agouti-related protein precursor","131","This gene encodes a protein that regulates feeding behavior and plays a key role in the control of body weight. The encoded protein acts as an antagonist of melanocortin receptor signaling. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2012]. "
9897a9866
> "P56473-1","NP_001258735.1","agouti-related protein precursor","131","This gene encodes a protein that regulates feeding behavior and plays a key role in the control of body weight. The encoded protein acts as an antagonist of melanocortin receptor signaling. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2012]. "
9903c9872
< "O88286-1","NP_997603.3","protein Wiz isoform 1","956",""
---
> "O88286-1","NP_035847.2","protein Wiz isoform 2","955",""
9912,9913d9880
< "Q9Z1M7-1","NP_034817.1","LARGE xylosyl- and glucuronyltransferase 1","756",""
< "Q91ZE9-1","NP_612186.2","bcl-2-modifying factor isoform 1","271",""
9917,9918d9883
< "Q6P9S0-1","NP_941027.1","protein MTSS 2 isoform 1","715",""
< "Q61419-1","NP_031743.3","cytidine monophosphate-N-acetylneuraminic acid hydroxylase isoform a","577",""
9921c9886
< "Q8BZZ3-1","NP_796301.2","NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform 1","918",""
---
> "P48381-1","NP_001159886.1","transcription factor RFX3 isoform 1","749",""
9923a9889
> "Q3UJD6-1","NP_001161843.1","ubiquitin carboxyl-terminal hydrolase 19 isoform 2","1324",""
9925d9890
< "Q99PI4-1","NP_075021.1","phosphatidate phosphatase LPIN3","848",""
9927a9893,9894
> "Q99PI4-1","NP_001186047.1","phosphatidate phosphatase LPIN3","848",""
> "Q9ESZ8-1","NP_001074215.1","general transcription factor II-I isoform 1","998",""
9933a9901
> "Q7TNK1-1","NP_001020089.1","transcription factor RFX4 isoform 1","735",""
9935,9936c9903
< "Q99JY9-1","NP_076224.1","actin-related protein 3","418",""
< "Q9ESZ8-1","NP_034495.2","general transcription factor II-I isoform 2","979",""
---
> "Q8R3G9-1","NP_001162150.1","tetraspanin-8","235",""
9940d9906
< "Q812G0-1","NP_776295.1","alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 1","535",""
9947a9914
> "P84075-1","NP_001123891.1","neuron-specific calcium-binding protein hippocalcin","193",""
9950c9917,9918
< "Q3UJD6-1","NP_663382.2","ubiquitin carboxyl-terminal hydrolase 19 isoform 5","1299",""
---
> "Q60989-1","NP_001288568.1","E3 ubiquitin-protein ligase XIAP","496","The protein encoded by this gene is a member of the inhibitor of apoptosis (IAP) family of proteins. While first identified for its role in blocking apoptosis, this protein modulates many other signaling processes including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways and inflammatory responses. This protein blocks apoptosis by binding and inhibiting target caspases after they have been activated. Binding occurs to some, but not all, caspases. This protein has several conserved regions, including baculoviral IAP repeat (BIR) motifs and a RING finger E3 ligase domain. In humans, mutations in this gene are linked to immunodeficiency in X-linked lymphoproliferative syndrome type-2 (XLP-2). A pseudogene of this gene is found on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. "
> "Q62108-1","NP_001103222.1","disks large homolog 4 isoform 2","721",""
9952d9919
< "Q60989-1","NP_033818.2","E3 ubiquitin-protein ligase XIAP","496","The protein encoded by this gene is a member of the inhibitor of apoptosis (IAP) family of proteins. While first identified for its role in blocking apoptosis, this protein modulates many other signaling processes including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways and inflammatory responses. This protein blocks apoptosis by binding and inhibiting target caspases after they have been activated. Binding occurs to some, but not all, caspases. This protein has several conserved regions, including baculoviral IAP repeat (BIR) motifs and a RING finger E3 ligase domain. In humans, mutations in this gene are linked to immunodeficiency in X-linked lymphoproliferative syndrome type-2 (XLP-2). A pseudogene of this gene is found on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. "
9954a9922
> "Q3URY2-1","NP_001013783.1","geminin coiled-coil domain-containing protein 1 isoform 1","339",""
9960,9963c9928
< "Q3U2S8-1","NP_083028.1","voltage-gated hydrogen channel 1","269",""
< "Q62108-1","NP_031890.1","disks large homolog 4 isoform 1","724",""
< "Q9WTK2-1","NP_034011.1","chromodomain Y-like protein isoform 1","593",""
< "P27811-1","NP_034867.3","killer cell lectin-like receptor subfamily B member 1A isoform 1","233",""
---
> "Q9Z1M7-1","NP_001304320.1","LARGE xylosyl- and glucuronyltransferase 1","756",""
9966a9932
> "Q8BZZ3-1","NP_001263221.1","NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform 2","787",""
9969d9934
< "P84075-1","NP_034601.1","neuron-specific calcium-binding protein hippocalcin","193",""
9974,9975c9939,9941
< "Q64692-1","NP_033209.1","CMP-N-acetylneuraminate-poly-alpha-2, 8-sialyltransferase isoform 1 precursor","359",""
< "P50481-1","NP_034841.2","LIM/homeobox protein Lhx3 isoform b","400",""
---
> "Q61419-1","NP_001104580.1","cytidine monophosphate-N-acetylneuraminic acid hydroxylase isoform a","577",""
> "Q9WTK2-1","NP_001116858.1","chromodomain Y-like protein isoform 2","544",""
> "Q6P9S0-1","NP_001297520.1","protein MTSS 2 isoform 2","653",""
9977,9978d9942
< "Q99P72-2","NP_918942.1","reticulon-4 isoform B2","375",""
< "P48381-1","NP_035395.2","transcription factor RFX3 isoform 1","749",""
9980a9945
> "P27811-1","NP_001153374.1","killer cell lectin-like receptor subfamily B member 1A isoform 2","200",""
9983d9947
< "P97325-1","NP_033202.3","CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform a","374",""
9985c9949
< "Q7TNK1-1","NP_081965.2","transcription factor RFX4 isoform 2","641",""
---
> "P50481-1","NP_001034742.1","LIM/homeobox protein Lhx3 isoform a","402",""
9986a9951
> "Q64692-1","NP_001153217.1","CMP-N-acetylneuraminate-poly-alpha-2, 8-sialyltransferase isoform 2 precursor","266",""
9988a9954,9955
> "P97325-1","NP_001155246.1","CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform a","374",""
> "Q99JY9-1","NP_001192314.1","actin-related protein 3","418",""
9992d9958
< "Q8R3G9-1","NP_666122.1","tetraspanin-8","235",""
9995a9962
> "Q99P72-2","NP_077188.1","reticulon-4 isoform C","199",""
9999a9967
> "Q3U2S8-1","NP_001035954.1","voltage-gated hydrogen channel 1","269",""
10000a9969
> "Q812G0-1","NP_001277730.1","alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 2","526",""
10007,10008d9975
< "Q3URQ7-1","NP_766349.1","methenyltetrahydrofolate synthase domain-containing protein isoform 2","353",""
< "Q6PCP5-1","NP_083685.2","mitochondrial fission factor isoform 1","291",""
10010,10011c9977
< "Q7TMK6-1","NP_573518.2","protein Hook homolog 2 isoform 1","716",""
< "Q8BTG7-1","NP_663577.1","protein NDRG4 isoform B","339",""
---
> "Q3URQ7-1","NP_001159954.1","methenyltetrahydrofolate synthase domain-containing protein isoform 1","372",""
10015a9982
> "Q8BTG7-1","NP_001181935.1","protein NDRG4 isoform A","352",""
10016a9984
> "Q7TMK6-1","NP_001161463.1","protein Hook homolog 2 isoform 2","715",""
10020,10021d9987
< "P05017-1","NP_034642.2","insulin-like growth factor I isoform 1","159","This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. This gene is predominantly expressed in the liver and the encoded protein undergoes proteolytic processing to generate a disulfide-linked mature polypeptide. Transgenic disruption of this gene in mice results in reduced postnatal survival and severe growth retardation. Mice lacking the encoded protein exhibit generalized organ hypoplasia including underdevelopment of the central nervous system and developmental defects in bone, muscle and reproductive systems. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]. "
< "Q9R0G7-1","NP_056568.2","zinc finger E-box-binding homeobox 2","1215",""
10022a9989,9990
> "Q9R0G7-1","NP_001276450.1","zinc finger E-box-binding homeobox 2","1215",""
> "P05017-1","NP_001104745.1","insulin-like growth factor I isoform 4 preproprotein","153","This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. This gene is predominantly expressed in the liver and the encoded protein undergoes proteolytic processing to generate a disulfide-linked mature polypeptide. Transgenic disruption of this gene in mice results in reduced postnatal survival and severe growth retardation. Mice lacking the encoded protein exhibit generalized organ hypoplasia including underdevelopment of the central nervous system and developmental defects in bone, muscle and reproductive systems. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]. "
10024,10026c9992
< "Q7TNT2-1","NP_848912.1","fatty acyl-CoA reductase 2 isoform 2","502",""
< "Q811S7-1","NP_038727.1","upstream-binding protein 1 isoform b","504",""
< "K9J7H2-1","NP_001160635.1","vomeronasal 1 receptor Vmn1r106","306",""
---
> "Q7TNT2-1","NP_001334445.1","fatty acyl-CoA reductase 2 isoform 1","515",""
10028,10029c9994
< "K9J7G2-1","NP_001160625.1","vomeronasal 1 receptor Vmn1r96","307",""
< "Q9ES89-1","NP_067363.3","exostosin-like 2 isoform a","330",""
---
> "K7N6B8-1","NP_001161045.1","vomeronasal 1 receptor 250","321",""
10030a9996,9999
> "D3YZG3-1","NP_001160620.1","vomeronasal 1 receptor Vmn1r92","307",""
> "K9J7H2-1","NP_001160634.1","vomeronasal 1 receptor Vmn1r154","306",""
> "Q811S7-1","NP_001076788.1","upstream-binding protein 1 isoform a","540",""
> "K9J7G2-1","NP_001160624.1","vomeronasal 1 receptor Vmn1r144","307",""
10032c10001,10002
< "K7N6J2-1","NP_001160223.1","vomeronasal 1 receptor Vmn1r147","305",""
---
> "K9J7F4-1","NP_001160183.1","vomeronasal 1 receptor Vmn1r136","307",""
> "D3YTW8-1","NP_001160636.1","vomeronasal 1 receptor Vmn1r161","314",""
10034,10038c10004
< "D3YTX5-1","NP_001160639.1","vomeronasal 1 receptor Vmn1r134","305",""
< "K9J7F4-1","NP_001160228.1","vomeronasal 1 receptor Vmn1r164","307",""
< "K9J7G6-1","NP_001160631.1","vomeronasal 1 receptor Vmn1r146","307",""
< "K9J7G4-1","NP_001160623.1","vomeronasal 1 receptor Vmn1r97","306",""
< "K9J7G9-1","NP_001160619.1","vomeronasal 1 receptor Vmn1r153","307",""
---
> "K9J7G6-1","NP_001160630.1","vomeronasal 1 receptor Vmn1r98","307",""
10040c10006
< "D3YTW8-1","NP_001160637.1","vomeronasal 1 receptor Vmn1r133","314",""
---
> "K7N6J2-1","NP_001160185.1","vomeronasal 1 receptor Vmn1r99","305",""
10042c10008,10013
< "Q9DD06-1","NP_082128.1","retinoic acid receptor responder protein 2 isoform 2 preproprotein","162",""
---
> "K9J7G9-1","NP_001160618.1","vomeronasal 1 receptor Vmn1r105","307",""
> "K9J7G4-1","NP_001160622.1","vomeronasal 1 receptor Vmn1r145","306",""
> "D3YTX5-1","NP_001160638.1","vomeronasal 1 receptor Vmn1r162","305",""
> "Q9ES89-1","NP_001156986.1","exostosin-like 2 isoform a","330",""
> "Q8BVZ5-1","NP_001158196.1","interleukin-33","266",""
> "P43431-1","NP_001152896.1","interleukin-12 subunit alpha isoform 1","236",""
10049,10051d10019
< "O35627-1","NP_033933.2","nuclear receptor subfamily 1 group I member 3 isoform 1","358",""
< "Q6PFD5-1","NP_941020.1","disks large-associated protein 3","977",""
< "P98078-1","NP_075607.2","disabled homolog 2 isoform a","766",""
10052a10021
> "Q9DD06-1","NP_001334097.1","retinoic acid receptor responder protein 2 isoform 2 preproprotein","162",""
10053a10023
> "Q69Z26-1","NP_001103219.1","contactin-4 isoform 1 precursor","1026",""
10055d10024
< "Q3V140-1","NP_058541.2","acrosin-binding protein isoform 1 precursor","540",""
10057,10058c10026
< "Q9QXV9-1","NP_036026.1","protein sprouty homolog 1","313",""
< "Q8CIG8-1","NP_038796.2","protein arginine N-methyltransferase 5 isoform 1","637","This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation and the assembly of small nuclear ribonucleoproteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. "
---
> "O08599-1","NP_001107041.1","syntaxin-binding protein 1 isoform a","603",""
10065a10034
> "Q8BVZ1-1","NP_001070816.1","perilipin-5","463",""
10067d10035
< "Q9D6T0-1","NP_079809.1","nitric oxide synthase-interacting protein isoform 1","301",""
10071a10040
> "Q6PFD5-1","NP_001289010.1","disks large-associated protein 3","977",""
10073,10074d10041
< "Q8BG87-1","NP_001334242.1","methylcytosine dioxygenase TET3 isoform 1","1803",""
< "P28843-1","NP_034204.1","dipeptidyl peptidase 4 isoform 1","760",""
10075a10043
> "Q8R367-1","NP_001157684.1","ras-related and estrogen-regulated growth inhibitor isoform a","199",""
10079a10048,10049
> "P32648-1","NP_001300898.1","VIP peptides isoform 2 preproprotein","170","This gene encodes a neuropeptide of the glucagon/secretin superfamily with potent bronchodilator, immunomodulator and anti-inflammatory properties. The encoded protein is proteolytically processed to generate two structurally similar neuropeptides - vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI). In the digestive tract, VIP stimulates relaxation of enteric smooth muscle, secretion of water and electrolytes, release of insulin and glucagon, and inhibition of gastric acid secretion. In the cardiovascular system, VIP causes coronary vasodilation and stimulates contractility in the heart. Mice lacking VIP exhibit airway hyperresponsiveness and airway inflammation. Male mice lacking VIP exhibit moderate pulmonary arterial hypertension resulting in increased mortality. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. "
> "Q70IV5-1","NP_899135.3","synemin isoform L","371",""
10081d10050
< "Q8BVZ1-1","NP_080150.2","perilipin-5","463",""
10087d10055
< "Q8R367-1","NP_871788.1","ras-related and estrogen-regulated growth inhibitor isoform a","199",""
10089d10056
< "Q9QY23-1","NP_062736.2","plakophilin-3 isoform 1","797",""
10090a10058,10059
> "P97474-1","NP_001035967.1","pituitary homeobox 2 isoform c","324",""
> "P98078-1","NP_001008702.1","disabled homolog 2 isoform b","548",""
10092d10060
< "P06804-1","NP_038721.1","tumor necrosis factor isoform 1","235","This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure. This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions. It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation. In mouse deficiency of this gene is associated with defects in response to bacterial infection, with defects in forming organized follicular dendritic cell networks and germinal centers, and with a lack of primary B cell follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]. "
10095d10062
< "Q924A2-4","NP_082158.2","protein capicua homolog isoform CIC-S","1604",""
10097c10064,10066
< "Q8K341-1","NP_082752.3","alpha-tubulin N-acetyltransferase 1 isoform 3","310",""
---
> "P28843-1","NP_001153015.1","dipeptidyl peptidase 4 isoform 2","729",""
> "Q3V140-1","NP_001120812.1","acrosin-binding protein isoform 2 precursor","316",""
> "P55144-1","NP_001277729.1","tyrosine-protein kinase receptor TYRO3 isoform B","876",""
10098a10068
> "P97819-1","NP_001185952.1","85/88 kDa calcium-independent phospholipase A2 isoform 2","807",""
10100d10069
< "Q70IV5-1","NP_997546.2","synemin isoform M","1259",""
10104d10072
< "Q06219-1","NP_038641.1","nuclear receptor subfamily 4 group A member 2","598",""
10106d10073
< "Q80XD1-1","NP_076032.2","beta-chimaerin isoform 1","332",""
10110,10111c10077
< "P43431-1","NP_032377.1","interleukin-12 subunit alpha isoform 2 precursor","215",""
< "P97819-1","NP_058611.1","85/88 kDa calcium-independent phospholipase A2 isoform 1","752",""
---
> "Q9QY23-1","NP_001156396.1","plakophilin-3 isoform 2","822",""
10113d10078
< "Q8BVZ5-1","NP_598536.2","interleukin-33","266",""
10115d10079
< "Q62523-1","NP_035907.1","zyxin isoform a","564",""
10117d10080
< "Q922S4-1","NP_001137320.1","cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 6","939",""
10119,10120d10081
< "P97474-1","NP_035228.2","pituitary homeobox 2 isoform b","317",""
< "O08599-1","NP_033321.2","syntaxin-binding protein 1 isoform b","594",""
10124d10084
< "Q69Z26-1","NP_766592.2","contactin-4 isoform 2 precursor","705",""
10126a10087
> "Q8K341-1","NP_001136216.1","alpha-tubulin N-acetyltransferase 1 isoform 1","421",""
10131a10093,10094
> "Q922S4-1","NP_001137321.1","cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor","928",""
> "Q06219-1","NP_001132981.1","nuclear receptor subfamily 4 group A member 2","598",""
10132a10096,10097
> "Q9QXV9-1","NP_001292369.1","protein sprouty homolog 1","313",""
> "Q62523-1","NP_001276546.1","zyxin isoform a","564",""
10133a10099
> "O35627-1","NP_001229991.1","nuclear receptor subfamily 1 group I member 3 isoform 2","286",""
10136c10102
< "Q99KB8-1","NP_077246.2","hydroxyacylglutathione hydrolase, mitochondrial isoform 1 precursor","309",""
---
> "Q9D6T0-1","NP_001157156.1","nitric oxide synthase-interacting protein isoform 2","276",""
10137a10104
> "P70166-1","NP_001239454.1","cytoplasmic polyadenylation element-binding protein 1 isoform 1","562",""
10141a10109
> "P06804-1","NP_001265530.1","tumor necrosis factor isoform 2","219","This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure. This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions. It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation. In mouse deficiency of this gene is associated with defects in response to bacterial infection, with defects in forming organized follicular dendritic cell networks and germinal centers, and with a lack of primary B cell follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]. "
10142a10111,10112
> "Q924A2-4","NP_001289740.1","protein capicua homolog isoform CIC-L","2510",""
> "Q80XD1-1","NP_001298062.1","beta-chimaerin isoform 3","282",""
10144a10115
> "P03958-1","NP_001258981.1","adenosine deaminase","352",""
10149d10119
< "P32648-1","NP_035832.1","VIP peptides isoform 1 preproprotein","171","This gene encodes a neuropeptide of the glucagon/secretin superfamily with potent bronchodilator, immunomodulator and anti-inflammatory properties. The encoded protein is proteolytically processed to generate two structurally similar neuropeptides - vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI). In the digestive tract, VIP stimulates relaxation of enteric smooth muscle, secretion of water and electrolytes, release of insulin and glucagon, and inhibition of gastric acid secretion. In the cardiovascular system, VIP causes coronary vasodilation and stimulates contractility in the heart. Mice lacking VIP exhibit airway hyperresponsiveness and airway inflammation. Male mice lacking VIP exhibit moderate pulmonary arterial hypertension resulting in increased mortality. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. "
10157,10158d10126
< "P70166-1","NP_031781.1","cytoplasmic polyadenylation element-binding protein 1 isoform 2","561",""
< "P55144-1","NP_062265.2","tyrosine-protein kinase receptor TYRO3 isoform A precursor","880",""
10165c10133
< "Q80X53-1","NP_084055.2","coiled-coil domain-containing protein 116 isoform 1","541",""
---
> "Q80X53-1","NP_001293098.1","coiled-coil domain-containing protein 116 isoform 1","541",""
10167a10136
> "Q9DBC7-1","NP_001300902.1","cAMP-dependent protein kinase type I-alpha regulatory subunit","381","The encoded protein is a regulatory subunit of the cAMP-dependent protein kinase (PKA) complex, which is responsible for transducing most of the cAMP signals in eukaryotic cells. The inactive PKA complex contains two regulatory and two catalytic subunits. Binding of cAMP dissociates the complex, allowing monomeric catalytic subunits to phosphorylate cytosolic proteins or induce gene expression in the nucleus. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]. "
10173a10143
> "Q9CYZ2-1","NP_001278126.1","tumor protein D54 isoform a","221",""
10177a10148
> "Q9D3H0-1","NP_001135422.1","transmembrane protein 80 isoform 1","123",""
10180,10181d10150
< "Q9CYZ2-1","NP_079758.2","tumor protein D54 isoform b","220",""
< "Q9D3H0-1","NP_082073.1","transmembrane protein 80 isoform 1","123",""
10182a10152
> "P33622-1","NP_001276685.1","apolipoprotein C-III isoform b precursor","99","This gene encodes an apolipoprotein which is the major protein component of very-low-density lipoproteins (VLDL) and a minor component of high-density lipoproteins (HDL). The encoded protein is thought to regulate the metabolism of triglyceride-rich lipoproteins and play a role in lipid storage and the mobilization of fat cells. This gene is clustered with three other apolipoprotein genes on chromosome 9 and is associated with coronary disease. Mice lacking this gene have lower levels of total cholesterol in the plasma. Mutations in the human genes causes hyperalphalipoproteinemia 2, a disorder of lipid metabolism which results in a favorable lipid profile (lower LDL-cholesterol, higher HDL-cholesterol and lower levels of serum triglycerides when fasting and after a meal). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. "
10185c10155
< "P58682-1","NP_573475.2","toll-like receptor 8 isoform 1 precursor","1032",""
---
> "P48346-1","NP_001241676.1","interleukin-15 preproprotein","162","This gene encodes a a pleiotropic cytokine of the interleukin family of proteins that plays important roles in the innate and adaptive cell homeostasis, as well as peripheral immune function. The encoded protein undergoes proteolytic processing to generate a mature cytokine that stimulates the proliferation of natural killer cells. The transgenic mice overexpressing the encoded protein exhibit an increase in the number of memory CD8+ T cells in a naive state and enhanced protection against bacterial infections. Mice lacking the encoded protein exhibit impaired protection against a strain of attenuated Mycobacterium. [provided by RefSeq, Aug 2016]. "
10191d10160
< "Q9Z148-1","NP_671493.1","histone-lysine N-methyltransferase EHMT2 isoform b","1172",""
10199a10169
> "Q9Z148-1","NP_001273502.1","histone-lysine N-methyltransferase EHMT2 isoform c","1229",""
10202c10172
< "Q61221-1","NP_034561.2","hypoxia-inducible factor 1-alpha isoform 2","836","This gene encodes the alpha subunit which, along with the beta subunit, forms a heterodimeric transcription factor that regulates the cellular and developmental response to reduced oxygen tension. The transcription factor has been shown to regulate genes involved in several biological processes, including erythropoiesis and angiogenesis which aid in increased delivery of oxygen to hypoxic regions. The transcription factor also plays a role in the induction of genes involved in cell proliferation and survival, energy metabolism, apoptosis, and glucose and iron metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. "
---
> "P58682-1","NP_001300689.1","toll-like receptor 8 isoform 2 precursor","1029",""
10204d10173
< "P48346-1","NP_032383.1","interleukin-15 preproprotein","162","This gene encodes a a pleiotropic cytokine of the interleukin family of proteins that plays important roles in the innate and adaptive cell homeostasis, as well as peripheral immune function. The encoded protein undergoes proteolytic processing to generate a mature cytokine that stimulates the proliferation of natural killer cells. The transgenic mice overexpressing the encoded protein exhibit an increase in the number of memory CD8+ T cells in a naive state and enhanced protection against bacterial infections. Mice lacking the encoded protein exhibit impaired protection against a strain of attenuated Mycobacterium. [provided by RefSeq, Aug 2016]. "
10209c10178
< "P33622-1","NP_075603.1","apolipoprotein C-III isoform b precursor","99","This gene encodes an apolipoprotein which is the major protein component of very-low-density lipoproteins (VLDL) and a minor component of high-density lipoproteins (HDL). The encoded protein is thought to regulate the metabolism of triglyceride-rich lipoproteins and play a role in lipid storage and the mobilization of fat cells. This gene is clustered with three other apolipoprotein genes on chromosome 9 and is associated with coronary disease. Mice lacking this gene have lower levels of total cholesterol in the plasma. Mutations in the human genes causes hyperalphalipoproteinemia 2, a disorder of lipid metabolism which results in a favorable lipid profile (lower LDL-cholesterol, higher HDL-cholesterol and lower levels of serum triglycerides when fasting and after a meal). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. "
---
> "Q61221-1","NP_001300848.1","hypoxia-inducible factor 1-alpha isoform 1","837","This gene encodes the alpha subunit which, along with the beta subunit, forms a heterodimeric transcription factor that regulates the cellular and developmental response to reduced oxygen tension. The transcription factor has been shown to regulate genes involved in several biological processes, including erythropoiesis and angiogenesis which aid in increased delivery of oxygen to hypoxic regions. The transcription factor also plays a role in the induction of genes involved in cell proliferation and survival, energy metabolism, apoptosis, and glucose and iron metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. "
10212,10214c10181
< "P53996-1","NP_038521.1","cellular nucleic acid-binding protein isoform 1","178",""
< "Q61103-1","NP_035392.1","zinc finger protein ubi-d4 isoform 2","391",""
< "P09240-1","NP_112438.1","cholecystokinin isoform 1 preproprotein","115","This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Homozygous knockout mice for this gene exhibit impaired insulin secretion, enhanced insulin sensitivity, and resistance to obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]. "
---
> "P53996-1","NP_001103215.1","cellular nucleic acid-binding protein isoform 2","171",""
10219c10186
< "Q91WT9-1","NP_835742.1","cystathionine beta-synthase isoform 2","547",""
---
> "Q91WT9-1","NP_001258282.1","cystathionine beta-synthase isoform 2","547",""
10224c10191
< "Q80TL4-1","NP_766278.1","PHD finger protein 24 isoform 2","363",""
---
> "Q80TL4-1","NP_001333455.1","PHD finger protein 24 isoform 1","400",""
10226,10227c10193,10194
< "Q8CI15-1","NP_079643.2","sphingosine kinase 1 isoform 2","382","This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]. "
< "Q8VDC0-1","NP_694808.1","probable leucine--tRNA ligase, mitochondrial isoform 1","902",""
---
> "Q8CI15-1","NP_001165943.1","sphingosine kinase 1 isoform 2","382","This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]. "
> "O54931-1","NP_001030609.1","A-kinase anchor protein 2 isoform 2","880",""
10230d10196
< "Q9R0K7-1","NP_033853.1","plasma membrane calcium-transporting ATPase 2 isoform 1","1198",""
10239d10204
< "Q8C1Z8-1","NP_780598.2","tRNA methyltransferase 10 homolog A","330",""
10250a10216
> "Q8C0R0-1","NP_001297591.1","ubiquitin carboxyl-terminal hydrolase 37 isoform 2","957",""
10253a10220
> "Q9CYH2-1","NP_001303661.1","peroxiredoxin-like 2A isoform a","232",""
10254a10222
> "Q6AXC6-1","NP_001003919.1","ATP-dependent DNA helicase DDX11 isoform 1","880",""
10256a10225
> "Q925P2-1","NP_001106839.1","carcinoembryonic antigen-related cell adhesion molecule 2 isoform a precursor","520",""
10258c10227
< "Q9D410-1","NP_001136163.1","DMRT-like family C1c isoform 1","238",""
---
> "Q5DU31-1","NP_001164271.1","interactor protein for cytohesin exchange factors 1 isoform 1","406",""
10259a10229,10230
> "Q8CDD9-1","NP_001034577.1","ligand-dependent nuclear receptor-interacting factor 1 isoform 1","755",""
> "Q9D3W1-1","NP_001157005.1","radial spoke head 14 homolog isoform 1","374",""
10260a10232
> "Q8BG87-1","NP_898961.2","methylcytosine dioxygenase TET3 isoform 2","1668",""
10261a10234
> "Q8CIG8-1","NP_001300835.1","protein arginine N-methyltransferase 5 isoform 2","618","This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation and the assembly of small nuclear ribonucleoproteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. "
10263d10235
< "Q3US41-1","NP_918944.2","epithelial splicing regulatory protein 1 isoform 1","681",""
10265a10238
> "A2RTL5-1","NP_001005525.1","arginine/serine-rich coiled-coil protein 2 isoform 1","434",""
10269c10242
< "A2AM05-1","NP_796359.1","centlein isoform 2","318",""
---
> "Q3U285-1","NP_001156545.1","ligand-dependent nuclear receptor corepressor-like protein isoform 1","600",""
10278a10252
> "Q24JP3-1","NP_001119518.1","protein FAM178B isoform A","523",""
10287a10262
> "Q7TNE3-1","NP_001161141.1","sperm-associated antigen 7 isoform 2","217",""
10296a10272
> "Q80Z10-1","NP_062387.2","astrotactin-2 isoform a precursor","1300",""
10298d10273
< "Q80Z10-1","NP_996992.1","astrotactin-2 isoform b precursor","1352",""
10303a10279
> "Q7TSH6-1","NP_001333728.1","SR-related and CTD-associated factor 4 isoform 2","1183",""
10305a10282
> "A2BE20-1","NP_001229872.1","KRAB box and zinc finger, C2H2 type domain containing protein-like","318",""
10310c10287,10288
< "Q7TPD1-1","NP_001335177.1","F-box only protein 11 isoform 2","843",""
---
> "Q7TPD1-1","NP_001074503.1","F-box only protein 11 isoform 1","930",""
> "Q8C0R7-1","NP_001025100.1","zinc finger MYND domain-containing protein 15 isoform 1","736",""
10312c10290
< "Q8CIW5-1","NP_722491.2","twinkle protein, mitochondrial isoform 1","685",""
---
> "Q8CIW5-1","NP_001335188.1","twinkle protein, mitochondrial isoform 2","287",""
10314a10293
> "Q4PJX1-1","NP_001070705.1","protein odr-4 homolog isoform 2","415",""
10320d10298
< "Q66JY2-3","NP_001108081.1","INO80 complex subunit D isoform 1","1021",""
10323a10302
> "Q8QZV4-1","NP_001156012.1","serine/threonine-protein kinase 32C isoform 2","370",""
10326a10306
> "A2ART0-1","NP_001092778.1","KRAB box and zinc finger, C2H2 type domain containing isoform 1","554",""
10327a10308
> "Q3UL33-1","NP_001116140.1","uncharacterized protein LOC665943","481",""
10333d10313
< "A2ART2-1","NP_001170878.1","KRAB box and zinc finger C2H2 type domain containing protein isoform 1","485",""
10337d10316
< "O54931-1","NP_001291473.1","paralemmin-2","1076","This locus represents naturally occurring readthrough transcription between the neighboring Palm2 (paralemmin 2) and Akap2 (A kinase (PRKA) anchor protein 2) genes on chromosome 4. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. Similar readthrough transcription has also been observed in human, as described in PMID: 11478809. [provided by RefSeq, Feb 2015]. "
10340d10318
< "Q8C7G5-1","NP_536682.2","apolipoprotein A-V precursor","368",""
10341a10320
> "Q8C3Q5-1","NP_001277220.1","protein shisa-7 isoform 2 precursor","541",""
10343,10344c10322
< "Q8C3Q5-1","NP_766325.3","protein shisa-7 isoform 1 precursor","558",""
< "Q8VDM6-1","NP_835190.1","heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform 2","340",""
---
> "Q8VDM6-1","NP_659171.1","heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform 1","859",""
10345a10324
> "Q9JMA7-1","NP_001098629.1","cytochrome P450 3A41","504",""
10349c10328,10329
< "A2A7W1-1","NP_001095127.1","predicted gene 11711 precursor","245",""
---
> "Q7TQC5-1","NP_001020615.1","aprataxin isoform b","335",""
> "A2A7W1-1","NP_001095126.1","CD300 molecule like family member D4 precursor","245",""
10353c10333
< "A2ART4-1","NP_001243409.1","uncharacterized protein LOC100043915","498",""
---
> "A2ART4-1","NP_001092819.1","KRAB box and zinc finger, C2H2 type domain containing","498",""
10356a10337
> "A2ART2-1","NP_001170877.1","KRAB box and zinc finger C2H2 type domain containing protein isoform 1","485",""
10373,10374c10354
< "Q9DBC7-1","NP_068680.1","cAMP-dependent protein kinase type I-alpha regulatory subunit","381","The encoded protein is a regulatory subunit of the cAMP-dependent protein kinase (PKA) complex, which is responsible for transducing most of the cAMP signals in eukaryotic cells. The inactive PKA complex contains two regulatory and two catalytic subunits. Binding of cAMP dissociates the complex, allowing monomeric catalytic subunits to phosphorylate cytosolic proteins or induce gene expression in the nucleus. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]. "
< "A2AHG0-1","NP_922936.3","leucine zipper putative tumor suppressor 3 isoform a","700",""
---
> "Q8BXJ8-1","NP_001106870.1","zinc finger protein 385B isoform 2","394",""
10381,10382c10361
< "A8DUK4-1","NP_032246.2","hemoglobin, beta adult t chain","147","This gene encodes a beta polypeptide chain found in adult hemoglobin, which consists of a tetramer of two alpha chains and two beta chains, and which functions in the transport of oxygen to various peripheral tissues. This gene is one of a cluster of beta-hemoglobin genes that are distally regulated by a locus control region, and which are organized along the chromosome in the order of their developmental expression. In mouse, two major strain-specific haplotypes of the beta-globin gene cluster are found - a 'single' haplotype found in C57BL/-type strains, which includes two highly similar adult beta-globin genes, beta s and beta t, and a 'diffuse' haplotype found in strains such as BALB/c and 129Sv, which includes two somewhat diverse adult beta-globin genes, beta-major and beta-minor. This gene represents the beta t adult gene found in the 'single' haplotype. Primary chromosome 7 of the mouse reference genome assembly, which is derived from C57BL/6 strain mice, represents the 'single' haplotype, while the 'diffuse' haplotype is represented in the reference genome collection by the BALB/c strain alternate contig, NT_095534.1. [provided by RefSeq, May 2013]. "
< "Q8VD58-1","NP_666135.1","protein EVI2B precursor","444","This locus represents naturally occurring readthrough transcription between the neighboring Evi2a (ecotropic viral integration site 2a) and Evi2b (ecotropic viral integration site 2b) genes on chromosome 11. The readthrough transcript encodes a protein identical to that of the downstream gene product. [provided by RefSeq, May 2013]. "
---
> "Q61103-1","NP_001278007.1","zinc finger protein ubi-d4 isoform 1","405",""
10391,10392d10369
< "Q61908-1","NP_034969.1","cx9C motif-containing protein 4","68",""
< "Q05020-1","NP_001296728.1","apolipoprotein C-II precursor","97","This locus represents naturally occurring read-through transcription between the neighboring apolipoprotein C-IV (Apoc4) and apolipoprotein C-II (Apoc2) genes on chromosome 7. The readthrough transcript encodes a protein that shares sequence identity with the downstream gene (Apoc2). [provided by RefSeq, Jun 2015]. "
10400c10377
< "D3Z1Q2-1","NP_001171202.1","melanocortin-2 receptor accessory protein 2","207",""
---
> "D3Z1Q2-1","NP_001094952.2","melanocortin-2 receptor accessory protein 2","207",""
10403c10380
< "O88904-1","NP_034562.2","homeodomain-interacting protein kinase 1 isoform 1","1210",""
---
> "O88904-1","NP_001288233.1","homeodomain-interacting protein kinase 1 isoform 1","1210",""
10405c10382
< "Q9WU38-1","NP_035455.1","amiloride-sensitive sodium channel subunit beta","638",""
---
> "Q8K450-1","NP_001258462.1","sperm-associated antigen 16 protein isoform 3","405",""
10408c10385
< "Q9Z202-1","NP_034782.1","NKG2-A/NKG2-B type II integral membrane protein isoform 2","227",""
---
> "Q61069-1","NP_001292605.1","upstream stimulatory factor 1 isoform 1","310","This protein encoded by this gene is a member of the basic-Helix-Hoop-Helix-Leucine zipper (bHLH-LZ) family and encodes a protein that can act as a transcription factor. Studies indicate that the basic region interacts with DNA at E-Box motifs, while the helix-loop-helix and leucine zipper domains are involved in dimerization with different partners. This protein is involved in a wide array of biological pathways, including cell cycle regulation, immune response, and responses to ultraviolet radiation. Mice lacking most of the coding exons of this gene often lacked both whiskers and nasal fur, and were prone to epileptic seizures, while mice lacking both this gene and another family member, Usf2, displayed embryonic lethality (PMID:9520440). Mutations in the human ortholog of this gene have been associated with Familial Combined Hyperlipidemia (FCHL) in humans. Pseudogenes of this gene are found on chromosome 11 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]. "
10413c10390
< "Q5DW34-1","NP_001103157.1","histone-lysine N-methyltransferase EHMT1 isoform 4","1248",""
---
> "Q61985-1","NP_001123922.1","endoplasmic reticulum membrane sensor NFE2L1 isoform 1","741","This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases from the use of NRF1 for this gene, NFE2L1, and for 'nuclear respiratory factor 1' which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]. "
10415c10392
< "O54990-1","NP_001157055.1","prominin-1 isoform s6 precursor","823",""
---
> "Q8BG84-1","NP_001106945.1","leukocyte-associated immunoglobulin-like receptor 1 isoform a precursor","263",""
10417c10394
< "Q61985-1","NP_032712.2","endoplasmic reticulum membrane sensor NFE2L1 isoform 1","741","This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases from the use of NRF1 for this gene, NFE2L1, and for 'nuclear respiratory factor 1' which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]. "
---
> "Q5DW34-1","NP_001012536.2","histone-lysine N-methyltransferase EHMT1 isoform 1","1296",""
10422d10398
< "O35298-1","NP_036184.1","acyloxyacyl hydrolase isoform 1 preproprotein","574","This genes encodes an enzyme that catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides. The encoded protein modulates host inflammatory response to gram-negative bacteria. The proprotein is further cleaved into a large and small chain that interact in a heterodimer. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Aug 2013]. "
10423a10400
> "Q9Z202-1","NP_001275593.1","NKG2-A/NKG2-B type II integral membrane protein isoform 3","210",""
10426a10404
> "O54990-1","NP_001157050.1","prominin-1 isoform s3 precursor","834",""
10427a10406,10407
> "Q9WU38-1","NP_001258952.1","amiloride-sensitive sodium channel subunit beta","638",""
> "Q99P87-1","NP_001191888.1","resistin precursor","114",""
10429,10430d10408
< "Q8BG84-1","NP_848726.1","leukocyte-associated immunoglobulin-like receptor 1 isoform b precursor","153",""
< "Q8K450-1","NP_083436.2","sperm-associated antigen 16 protein isoform 1","639",""
10432,10433d10409
< "Q61069-1","NP_033506.1","upstream stimulatory factor 1 isoform 1","310","This protein encoded by this gene is a member of the basic-Helix-Hoop-Helix-Leucine zipper (bHLH-LZ) family and encodes a protein that can act as a transcription factor. Studies indicate that the basic region interacts with DNA at E-Box motifs, while the helix-loop-helix and leucine zipper domains are involved in dimerization with different partners. This protein is involved in a wide array of biological pathways, including cell cycle regulation, immune response, and responses to ultraviolet radiation. Mice lacking most of the coding exons of this gene often lacked both whiskers and nasal fur, and were prone to epileptic seizures, while mice lacking both this gene and another family member, Usf2, displayed embryonic lethality (PMID:9520440). Mutations in the human ortholog of this gene have been associated with Familial Combined Hyperlipidemia (FCHL) in humans. Pseudogenes of this gene are found on chromosome 11 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]. "
< "Q99P87-1","NP_075360.1","resistin precursor","114",""
10444d10419
< "P34152-3","NP_032008.2","focal adhesion kinase 1 isoform 1","1052",""
10448c10423
< "Q2VPQ9-1","NP_081586.1","chromatin modification-related protein MEAF6 isoform 1","192",""
---
> "Q2VPQ9-1","NP_001277630.1","chromatin modification-related protein MEAF6 isoform 2","191",""
10452c10427
< "P60007-1","NP_081808.2","anaphase-promoting complex subunit 15 isoform c","132",""
---
> "P60007-1","NP_001278277.1","anaphase-promoting complex subunit 15 isoform a","141",""
10454c10429
< "P08680-1","NP_033783.1","5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform a","587",""
---
> "Q80TF3-1","NP_001098715.1","protocadherin-19 isoform a precursor","1145",""
10455a10431,10432
> "Q99PV8-1","NP_001073352.1","B-cell lymphoma/leukemia 11B isoform a","884",""
> "Q62442-1","NP_001074026.1","vesicle-associated membrane protein 1 isoform b","117",""
10458a10436
> "O35216-1","NP_001289058.1","histone H3-like centromeric protein A isoform 2","108","Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]. "
10461,10462c10439
< "Q62442-1","NP_033522.1","vesicle-associated membrane protein 1 isoform a","118",""
< "Q8C8R3-1","NP_848770.2","ankyrin-2 isoform 2","1050",""
---
> "Q62210-1","NP_001278432.1","baculoviral IAP repeat-containing protein 2","612",""
10464,10465d10440
< "P97318-1","NP_796233.2","disabled homolog 1 isoform 2","555",""
< "Q99PV8-1","NP_067374.2","B-cell lymphoma/leukemia 11B isoform b","812",""
10466a10442
> "P62500-1","NP_033392.1","TSC22 domain family protein 1 isoform 2","143",""
10468a10445
> "Q9D3A9-1","NP_001001454.2","protein tweety homolog 1 isoform 1","460","This gene encodes a member of the Tweety family of membrane proteins. Members of this family contain five predicted transmembrane regions that are arranged in a characteristic pattern. In mouse, the protein is predominantly localized to the endoplasmic reticulum and displays calcium binding activity. Targeted knock out of this gene results in early embryonic lethality prior to the blastocyst stage. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
10472d10448
< "Q9R1Q6-1","NP_075543.1","transmembrane protein 176B","263",""
10477c10453
< "Q9WTN3-1","NP_035610.1","sterol regulatory element-binding protein 1 isoform a precursor","1134","This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. Alternatively spliced transcript variants have been characterized for this gene. [provided by RefSeq, Nov 2017]. "
---
> "Q5NCX5-1","NP_001013432.1","neuralized-like protein 4 isoform 1","1563",""
10479d10454
< "O08532-1","NP_033914.1","voltage-dependent calcium channel subunit alpha-2/delta-1 isoform e preproprotein","1084","This gene encodes a regulatory component of the voltage-dependent calcium channel complex. The product of this gene is a proprotein that is proteolytically processed into alpha-2 and delta subunits, which are linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]. "
10481c10456
< "Q76KF0-1","NP_954711.1","semaphorin-6D isoform Sema6D-4 precursor","1073",""
---
> "O55143-1","NP_001103610.1","sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b","1044",""
10485c10460,10461
< "Q00196-1","NP_035268.2","POU domain, class 2, transcription factor 2 isoform 2","479",""
---
> "P60879-1","NP_001277985.1","synaptosomal-associated protein 25 isoform b","206",""
> "Q80XP9-1","NP_001258607.1","serine/threonine-protein kinase WNK3 isoform 1","1757",""
10486a10463
> "Q8BWG8-1","NP_796205.1","beta-arrestin-1 isoform A","418",""
10488d10464
< "P16092-1","NP_034336.2","fibroblast growth factor receptor 1 isoform 1 precursor","822",""
10490a10467
> "Q924K8-1","NP_001164525.1","metastasis-associated protein MTA3 isoform 4","513",""
10496d10472
< "Q9EQU5-1","NP_076360.1","protein SET isoform 1","289",""
10500d10475
< "P28047-1","NP_033554.3","protein Wnt-7b isoform 1 precursor","349",""
10502a10478
> "P10923-1","NP_001191162.1","osteopontin isoform 4 precursor","294",""
10505d10480
< "P23927-1","NP_034094.1","alpha-crystallin B chain","175","This gene encodes a member of the small heat-shock protein (HSP20) family. The encoded protein is a molecular chaperone that protects proteins against thermal denaturation and other stresses. This protein is a component of the eye lens, regulates lens differentiation and functions as a refractive element in the lens. This protein is a negative regulator of inflammation, has anti-apoptotic properties and also plays a role in the formation of muscular tissue. Mice lacking this gene exhibit worse experimental autoimmune encephalomyelitis and inflammation of the central nervous system compared to the wild type. In mouse models, this gene has a critical role in alleviating the pathology of the neurodegenerative Alexander disease. Mutations in the human gene are associated with myofibrillar myopathy 2, fatal infantile hypertonic myofibrillar myopathy, multiple types of cataract and dilated cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. "
10506a10482
> "Q8CFG0-1","NP_001239507.1","extracellular sulfatase Sulf-2 isoform 1 precursor","875",""
10512a10489
> "Q8R2K4-1","NP_001171269.1","TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform 2","598",""
10514,10515c10491
< "P54846-1","NP_032762.1","neural retina-specific leucine zipper protein","237","This gene encodes a member of the basic leucine zipper domain family of transcription factors. The encoded protein is preferentially expressed in the retina and is necessary for rod photoreceptor development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]. "
< "G5E8K5-1","NP_733926.2","ankyrin-3 isoform i","838","This gene encodes a member of the ankyrin protein family. Ankyrins link integral membrane proteins to the spectrin-based cytoskeleton. Ankyrin family members share a protein structure which includes three independently folded domains: the N-terminal ankyrin repeat domain, the central spectrin-binding domain, and the C-terminal rod domain. This ankyrin functions as the major ankyrin in the kidney and may play a role in the polarized distribution of many integral membrane proteins to specific subcellular sites. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. "
---
> "Q76KF0-1","NP_001277926.1","semaphorin-6D isoform Sema6D-2 precursor","998",""
10521c10497
< "P09242-1","NP_031457.2","alkaline phosphatase, tissue-nonspecific isozyme preproprotein","524","This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is a membrane-bound glycosylated enzyme that catalyzes the hydrolysis of phosphate esters at alkaline pH. The mature peptide maintains the ratio of inorganic phosphate to inorganic pyrophosphate required for bone mineralization. Mice that lack this enzyme show symptoms of osteomalacia, softening of the bones. In humans, mutations in this gene are associated with hypophosphatasia, an inherited metabolic bone disease in which deficiency of this enzyme inhibits bone mineralization leading to skeletal defects. Mutations in the mouse gene mirror the symptoms of human hypophosphatasia. A pseudogene of this gene is present on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. "
---
> "P16092-1","NP_001073377.1","fibroblast growth factor receptor 1 isoform 2 precursor","820",""
10525a10502,10503
> "P70677-1","NP_001271338.1","caspase-3","277","This gene encodes a protein that belongs to a highly conserved family of cysteinyl aspartate-specific proteases that function as essential regulators of programmed cell death through apoptosis. Members of this family contain an N-terminal pro-domain and require cleavage at specific aspartate residues to become mature. The protein encoded by this gene belongs to a subgroup of cysteinyl aspartate-specific proteases that are activated by initiator caspases and that perform the proteolytic cleavage of apoptotic target proteins. Mice defective for this gene exhibit a variety of phenotypes including reduced neuronal apoptosis resulting in hyperplasias, hearing loss, attenuated osteogenic differentiation of bone marrow stromal stem cells, and pre- and post-natal lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. "
> "Q60611-1","NP_001157102.1","DNA-binding protein SATB1 isoform 1","764",""
10528,10529d10505
< "Q09LZ8-1","NP_084507.1","cytosolic carboxypeptidase 6 isoform 1","540",""
< "O55143-1","NP_033852.1","sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a","998",""
10532d10507
< "Q61288-1","NP_033742.2","serine/threonine-protein kinase receptor R3 isoform a precursor","502",""
10535d10509
< "P52927-1","NP_034571.1","high mobility group protein HMGI-C isoform 1","108",""
10537,10540c10511
< "Q9QX96-1","NP_056587.2","sal-like protein 2 isoform 1","1004",""
< "P15530-1","NP_032365.1","B-cell antigen receptor complex-associated protein beta chain isoform 1 precursor","228","The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2015]. "
< "O09105-1","NP_031527.1","neurogenic differentiation factor 4","330","This gene belongs to the neurogenic differentiation factor family and encodes a basic helix-loop-helix (bHLH) transcription factor which is expressed in the developing nervous system with high levels of expression in the brain, retina and cranial ganglions. Expression gradually becomes restricted to the neural retina. It is a key gene in the Ngn2-regulated neuronal differentiation pathway, coordinating the onset of cortical gene transcription. This gene also regulates amacrine cell fate determination in the retina. [provided by RefSeq, Jul 2016]. "
< "Q6RHR9-1","NP_034497.1","membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform a","1171",""
---
> "Q62440-1","NP_001272459.1","transducin-like enhancer protein 1 isoform c","696",""
10542c10513
< "Q9D3A9-1","NP_067299.2","protein tweety homolog 1 isoform 2","450","This gene encodes a member of the Tweety family of membrane proteins. Members of this family contain five predicted transmembrane regions that are arranged in a characteristic pattern. In mouse, the protein is predominantly localized to the endoplasmic reticulum and displays calcium binding activity. Targeted knock out of this gene results in early embryonic lethality prior to the blastocyst stage. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
---
> "P63015-1","NP_001231127.1","paired box protein Pax-6 isoform 1","436","This gene encodes a homeobox-containing protein that functions as a regulator of transcription. It plays a key role in the development of neural tissues, particularly the eye. Activity of this protein is also required for expression of glucagon in the pancreas. This gene is regulated by multiple enhancers located up to tens or hundreds of kilobases upstream and downstream of the transcription start sites. Mutations in this gene or deletion of these regulatory elements results in severe defects in eye development. Alternative splicing and the use of alternative promoters results in multiple transcript variants, some of which encode proteins that lack the N-terminal paired domain. [provided by RefSeq, Jul 2015]. "
10544,10545d10514
< "Q8CC27-1","NP_075605.1","voltage-dependent L-type calcium channel subunit beta-2 isoform 1","655",""
< "Q64701-1","NP_035379.2","retinoblastoma-like protein 1 isoform 1","1063",""
10557a10527,10528
> "Q64701-1","NP_001132988.1","retinoblastoma-like protein 1 isoform 2","594",""
> "Q9EQU5-1","NP_001191804.1","protein SET isoform 2","277",""
10560c10531
< "P49919-1","NP_034006.3","cyclin-dependent kinase inhibitor 1C isoform 2","335",""
---
> "Q6PHS9-1","NP_001167518.1","voltage-dependent calcium channel subunit alpha-2/delta-2 isoform 1 precursor","1156",""
10561a10533
> "Q09LZ8-1","NP_001041654.2","cytosolic carboxypeptidase 6 isoform 2","463",""
10566d10537
< "Q6PHS9-1","NP_064659.2","voltage-dependent calcium channel subunit alpha-2/delta-2 isoform 2 precursor","1154",""
10567a10539
> "P49919-1","NP_001155096.1","cyclin-dependent kinase inhibitor 1C isoform 1","348",""
10571,10572c10543,10544
< "Q8R2K4-1","NP_666204.2","TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform 1","623",""
< "P67871-1","NP_034105.1","casein kinase II subunit beta isoform 2","215","This gene encodes the beta subunit of the casein kinase 2 enzyme, which is a heterotetramer comprised of alpha and/or alpha-prime catalytic subunits and two regulatory beta subunits. Casein kinase 2 is involved in the regulation of several cellular processes including gene expression, protein synthesis and cell proliferation. Knockout of this gene in mice leads to embryonic lethality. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]. "
---
> "P15530-1","NP_001300868.1","B-cell antigen receptor complex-associated protein beta chain isoform 2 precursor","211","The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2015]. "
> "O08532-1","NP_001104313.1","voltage-dependent calcium channel subunit alpha-2/delta-1 isoform a preproprotein","1103","This gene encodes a regulatory component of the voltage-dependent calcium channel complex. The product of this gene is a proprotein that is proteolytically processed into alpha-2 and delta subunits, which are linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]. "
10576a10549,10551
> "Q6RHR9-1","NP_001025021.1","membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform c","1471",""
> "P34960-1","NP_001307005.1","macrophage metalloelastase isoform 2","420","This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein have a diminished capacity to degrade extracellular matrix components, do not develop emphysema in response to long-term exposure to cigarette smoke, and exhibit impaired clearance and increased mortality upon bacterial infection. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]. "
> "P22725-1","NP_001243153.1","protein Wnt-5a isoform 2 precursor","360",""
10578c10553
< "Q8CBC6-1","NP_034863.1","leucine-rich repeat neuronal protein 3 precursor","707",""
---
> "Q8CBC6-1","NP_001258637.1","leucine-rich repeat neuronal protein 3 precursor","707",""
10580d10554
< "Q8CFG0-1","NP_082348.2","extracellular sulfatase Sulf-2 isoform 1 precursor","875",""
10584a10559
> "Q9R1Q6-1","NP_001157679.1","transmembrane protein 176B","263",""
10591a10567
> "Q00196-1","NP_001157026.1","POU domain, class 2, transcription factor 2 isoform 4","583",""
10592a10569
> "Q9Z2K1-1","NP_001300887.1","keratin, type I cytoskeletal 16 isoform 1","470","The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The encoded protein is a cytokeratin and acts as an innate immune system effector, promoting the inflammatory response upon breach of the skin barrier. Defects in this gene are a cause of pachyonychia congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
10595d10571
< "Q9EQD0-1","NP_073558.2","frizzled-5 precursor","585",""
10607c10583
< "Q61286-1","NP_035674.2","transcription factor 12 isoform 1","706",""
---
> "Q9WTN3-1","NP_001300908.1","sterol regulatory element-binding protein 1 isoform b","1129","This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. Alternatively spliced transcript variants have been characterized for this gene. [provided by RefSeq, Nov 2017]. "
10610c10586,10587
< "P60879-1","NP_035558.1","synaptosomal-associated protein 25 isoform a","206",""
---
> "Q9JHG1-1","NP_001153088.1","phosphatidylinositol N-acetylglucosaminyltransferase subunit P isoform a","132",""
> "Q61288-1","NP_001264186.1","serine/threonine-protein kinase receptor R3 isoform a precursor","502",""
10617a10595
> "Q9CQ69-1","NP_001313543.1","cytochrome b-c1 complex subunit 8","82",""
10621c10599
< "P22725-1","NP_033550.2","protein Wnt-5a isoform 1 precursor","380",""
---
> "P52927-1","NP_001334099.1","high mobility group protein HMGI-C isoform 2","129",""
10623d10600
< "Q91V57-1","NP_786928.2","N-chimaerin isoform 1","334",""
10625,10627d10601
< "P10923-1","NP_033289.2","osteopontin isoform 4 precursor","294",""
< "P70160-1","NP_031613.2","calcitonin gene-related peptide 1 isoform Calca preproprotein","136","This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide (CGRP) and katacalcin. Alternative splicing of the mRNA results in multiple variants that encode either calcitonin or CGRP preproproteins. Post-translational processing of the calcitonin and CGRP propeptides results in either calcitonin and katacalcin, or CGRP, respectively. Calcitonin and katacalcin modulate calcium levels in the blood stream. CGRP can function as a vasodilator and play a role in the transmission of pain. The human homolog of CGRP was found to have antimicrobial activity. [provided by RefSeq, Mar 2015]. "
< "Q80XP9-1","NP_001258608.1","serine/threonine-protein kinase WNK3 isoform 2","1710",""
10633a10608
> "Q8BGD5-1","NP_001239399.1","carnitine O-palmitoyltransferase 1, brain isoform isoform 1","798",""
10636,10637d10610
< "Q62210-1","NP_031491.2","baculoviral IAP repeat-containing protein 2","612",""
< "Q3ULB5-1","NP_001139326.1","serine/threonine-protein kinase PAK 6","682",""
10640d10612
< "P34960-1","NP_032631.3","macrophage metalloelastase isoform 1 preproprotein","473","This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein have a diminished capacity to degrade extracellular matrix components, do not develop emphysema in response to long-term exposure to cigarette smoke, and exhibit impaired clearance and increased mortality upon bacterial infection. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]. "
10642d10613
< "Q924K8-1","NP_473423.1","metastasis-associated protein MTA3 isoform 2","591",""
10646a10618
> "P09242-1","NP_001274101.1","alkaline phosphatase, tissue-nonspecific isozyme preproprotein","524","This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is a membrane-bound glycosylated enzyme that catalyzes the hydrolysis of phosphate esters at alkaline pH. The mature peptide maintains the ratio of inorganic phosphate to inorganic pyrophosphate required for bone mineralization. Mice that lack this enzyme show symptoms of osteomalacia, softening of the bones. In humans, mutations in this gene are associated with hypophosphatasia, an inherited metabolic bone disease in which deficiency of this enzyme inhibits bone mineralization leading to skeletal defects. Mutations in the mouse gene mirror the symptoms of human hypophosphatasia. A pseudogene of this gene is present on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. "
10659d10630
< "Q8BGD5-1","NP_710146.1","carnitine O-palmitoyltransferase 1, brain isoform isoform 1","798",""
10661d10631
< "P70677-1","NP_033940.1","caspase-3","277","This gene encodes a protein that belongs to a highly conserved family of cysteinyl aspartate-specific proteases that function as essential regulators of programmed cell death through apoptosis. Members of this family contain an N-terminal pro-domain and require cleavage at specific aspartate residues to become mature. The protein encoded by this gene belongs to a subgroup of cysteinyl aspartate-specific proteases that are activated by initiator caspases and that perform the proteolytic cleavage of apoptotic target proteins. Mice defective for this gene exhibit a variety of phenotypes including reduced neuronal apoptosis resulting in hyperplasias, hearing loss, attenuated osteogenic differentiation of bone marrow stromal stem cells, and pre- and post-natal lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. "
10664d10633
< "P97863-1","NP_032713.3","nuclear factor 1 B-type isoform 3","420",""
10665a10635,10636
> "Q9EQD0-1","NP_001036124.1","frizzled-5 precursor","585",""
> "Q91V57-1","NP_001106717.2","N-chimaerin isoform 3","459",""
10667a10639
> "P70160-1","NP_001292545.1","calcitonin gene-related peptide 1 isoform Calca preproprotein","136","This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide (CGRP) and katacalcin. Alternative splicing of the mRNA results in multiple variants that encode either calcitonin or CGRP preproproteins. Post-translational processing of the calcitonin and CGRP propeptides results in either calcitonin and katacalcin, or CGRP, respectively. Calcitonin and katacalcin modulate calcium levels in the blood stream. CGRP can function as a vasodilator and play a role in the transmission of pain. The human homolog of CGRP was found to have antimicrobial activity. [provided by RefSeq, Mar 2015]. "
10670d10641
< "P63015-1","NP_038655.1","paired box protein Pax-6 isoform 1","436","This gene encodes a homeobox-containing protein that functions as a regulator of transcription. It plays a key role in the development of neural tissues, particularly the eye. Activity of this protein is also required for expression of glucagon in the pancreas. This gene is regulated by multiple enhancers located up to tens or hundreds of kilobases upstream and downstream of the transcription start sites. Mutations in this gene or deletion of these regulatory elements results in severe defects in eye development. Alternative splicing and the use of alternative promoters results in multiple transcript variants, some of which encode proteins that lack the N-terminal paired domain. [provided by RefSeq, Jul 2015]. "
10672a10644
> "P08680-1","NP_001095916.1","5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform b","572",""
10673a10646
> "Q8K007-1","NP_001185494.1","extracellular sulfatase Sulf-1 precursor","870",""
10675a10649
> "P28047-1","NP_001157105.1","protein Wnt-7b isoform 3","282",""
10677d10650
< "Q8BLC3-1","NP_659568.2","ly6/PLAUR domain-containing protein 1 isoform a precursor","141",""
10680,10682d10652
< "Q5NCX5-1","NP_001278048.1","neuralized-like protein 4 isoform 3","1539",""
< "Q9CQ69-1","NP_079628.1","cytochrome b-c1 complex subunit 8","82",""
< "Q9JHG1-1","NP_062416.1","phosphatidylinositol N-acetylglucosaminyltransferase subunit P isoform a","132",""
10684a10655
> "P62881-1","NP_034443.1","guanine nucleotide-binding protein subunit beta-5 isoform 1","395",""
10686c10657
< "Q8K007-1","NP_758498.1","extracellular sulfatase Sulf-1 precursor","870",""
---
> "Q8BLC3-1","NP_001298018.1","ly6/PLAUR domain-containing protein 1 isoform b","89",""
10687a10659
> "P67871-1","NP_001290374.1","casein kinase II subunit beta isoform 2","215","This gene encodes the beta subunit of the casein kinase 2 enzyme, which is a heterotetramer comprised of alpha and/or alpha-prime catalytic subunits and two regulatory beta subunits. Casein kinase 2 is involved in the regulation of several cellular processes including gene expression, protein synthesis and cell proliferation. Knockout of this gene in mice leads to embryonic lethality. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]. "
10689d10660
< "Q62440-1","NP_035729.3","transducin-like enhancer protein 1 isoform a","770",""
10691c10662
< "O35216-1","NP_031707.1","histone H3-like centromeric protein A isoform 1","134","Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]. "
---
> "P23927-1","NP_001276711.1","alpha-crystallin B chain","175","This gene encodes a member of the small heat-shock protein (HSP20) family. The encoded protein is a molecular chaperone that protects proteins against thermal denaturation and other stresses. This protein is a component of the eye lens, regulates lens differentiation and functions as a refractive element in the lens. This protein is a negative regulator of inflammation, has anti-apoptotic properties and also plays a role in the formation of muscular tissue. Mice lacking this gene exhibit worse experimental autoimmune encephalomyelitis and inflammation of the central nervous system compared to the wild type. In mouse models, this gene has a critical role in alleviating the pathology of the neurodegenerative Alexander disease. Mutations in the human gene are associated with myofibrillar myopathy 2, fatal infantile hypertonic myofibrillar myopathy, multiple types of cataract and dilated cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. "
10693a10665
> "Q8CC27-1","NP_001296448.1","voltage-dependent L-type calcium channel subunit beta-2 isoform 3","611",""
10696a10669
> "Q3ULB5-1","NP_001028426.2","serine/threonine-protein kinase PAK 6","682",""
10701c10674,10675
< "Q8BWG8-1","NP_835738.1","beta-arrestin-1 isoform B","410",""
---
> "P97318-1","NP_034144.1","disabled homolog 1 isoform 1","217",""
> "O09105-1","NP_001316418.1","neurogenic differentiation factor 4","330","This gene belongs to the neurogenic differentiation factor family and encodes a basic helix-loop-helix (bHLH) transcription factor which is expressed in the developing nervous system with high levels of expression in the brain, retina and cranial ganglions. Expression gradually becomes restricted to the neural retina. It is a key gene in the Ngn2-regulated neuronal differentiation pathway, coordinating the onset of cortical gene transcription. This gene also regulates amacrine cell fate determination in the retina. [provided by RefSeq, Jul 2016]. "
10703c10677
< "Q8BPM0-1","NP_766052.2","disheveled-associated activator of morphogenesis 1 isoform a","1077",""
---
> "P54846-1","NP_001129546.1","neural retina-specific leucine zipper protein","237","This gene encodes a member of the basic leucine zipper domain family of transcription factors. The encoded protein is preferentially expressed in the retina and is necessary for rod photoreceptor development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]. "
10706c10680
< "P62500-1","NP_997535.2","TSC22 domain family protein 1 isoform 1","1077",""
---
> "Q5DTM8-1","NP_001156735.1","E3 ubiquitin-protein ligase BRE1A isoform 1","973",""
10710d10683
< "Q60611-1","NP_033148.2","DNA-binding protein SATB1 isoform 1","764",""
10714,10715c10687,10689
< "Q5DTM8-1","NP_892044.1","E3 ubiquitin-protein ligase BRE1A isoform 1","973",""
< "Q9Z2K1-1","NP_032496.1","keratin, type I cytoskeletal 16 isoform 2","469","The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The encoded protein is a cytokeratin and acts as an innate immune system effector, promoting the inflammatory response upon breach of the skin barrier. Defects in this gene are a cause of pachyonychia congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
---
> "G5E8K5-1","NP_033800.2","ankyrin-3 isoform g","898","This gene encodes a member of the ankyrin protein family. Ankyrins link integral membrane proteins to the spectrin-based cytoskeleton. Ankyrin family members share a protein structure which includes three independently folded domains: the N-terminal ankyrin repeat domain, the central spectrin-binding domain, and the C-terminal rod domain. This ankyrin functions as the major ankyrin in the kidney and may play a role in the polarized distribution of many integral membrane proteins to specific subcellular sites. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. "
> "Q61286-1","NP_001240794.1","transcription factor 12 isoform 5","463",""
> "P97863-1","NP_001106680.1","nuclear factor 1 B-type isoform 1","570",""
10719d10692
< "Q80TF3-1","NP_001098716.1","protocadherin-19 isoform b precursor","1097",""
10721a10695
> "Q8C8R3-1","NP_001029340.1","ankyrin-2 isoform 3","933",""
10727d10700
< "P35583-1","NP_034576.2","hepatocyte nuclear factor 3-beta isoform b","459",""
10732,10733c10705,10706
< "Q91VI7-1","NP_660117.2","ribonuclease inhibitor isoform a","456",""
< "Q06180-1","NP_033003.1","tyrosine-protein phosphatase non-receptor type 2 isoform a","382",""
---
> "Q640N1-1","NP_001278786.1","adipocyte enhancer-binding protein 1 isoform 1 precursor","1129",""
> "P35639-1","NP_001277112.1","DNA damage-inducible transcript 3 protein","168",""
10737a10711
> "Q8CEE0-1","NP_001297650.1","centrosomal protein of 57 kDa isoform 2","474",""
10740d10713
< "O35717-1","NP_031732.1","suppressor of cytokine signaling 2","198",""
10742,10743d10714
< "P40224-2","NP_068350.1","stromal cell-derived factor 1 isoform alpha precursor","89","This gene encodes a member of the alpha chemokine protein family. The encoded protein is secreted and functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4. The encoded protein plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]. "
< "Q64249-1","NP_034394.1","nuclear receptor subfamily 6 group A member 1 isoform 1","495",""
10745,10746c10716
< "Q640N1-1","NP_033766.2","adipocyte enhancer-binding protein 1 isoform 2 precursor","1128",""
< "Q8BG60-1","NP_076208.2","thioredoxin-interacting protein isoform 2","396",""
---
> "Q91VI7-1","NP_001165571.1","ribonuclease inhibitor isoform a","456",""
10749a10720,10721
> "P70268-1","NP_001186522.1","serine/threonine-protein kinase N1 isoform 1","951",""
> "P53566-1","NP_001274443.1","CCAAT/enhancer-binding protein alpha isoform c","396","This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. The use of alternative in-frame non-AUG (CUG) and AUG start codons results in several protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the CUG and the first AUG start codons. [provided by RefSeq, Sep 2014]. "
10750a10723
> "P10852-1","NP_001154885.1","4F2 cell-surface antigen heavy chain isoform a","565",""
10752d10724
< "P10852-1","NP_032603.3","4F2 cell-surface antigen heavy chain isoform b","526",""
10755c10727
< "P70196-1","NP_033450.2","TNF receptor-associated factor 6","530","This gene encodes a member of the TNF receptor associated factor (TRAF) family of adaptor proteins that mediate signaling events from members of the TNF receptor and Toll/IL-1 receptor families to activate transcription factors such as NF-kappa-B and AP-1. The product of this gene is essential for perinatal and postnatal survival. Mice deficient in this protein exhibit osteopetrosis and defective in development of epidermal appendixes, normal B cell differentiation, lymph node organogenesis, interleukin-1 signaling, lipopolysaccharide signaling and neural tube closure. This protein possesses ubiquitin ligase activity. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]. "
---
> "P40224-2","NP_038683.1","stromal cell-derived factor 1 isoform beta precursor","93","This gene encodes a member of the alpha chemokine protein family. The encoded protein is secreted and functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4. The encoded protein plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]. "
10757d10728
< "Q8CEE0-1","NP_080941.3","centrosomal protein of 57 kDa isoform 1","500",""
10759c10730
< "P79621-1","NP_031601.1","MHC class II transactivator isoform 2","1078","This gene encodes a member of the NOD-like receptor protein family. This protein acts as a transcriptional coactivator and component of the enhanceosome complex to stimulate transcription of MHC class II genes in the adaptive immune response. This protein may also regulate the transcription of MHC class I genes. Mutations in the human gene have been linked to a rare immunodeficiency, bare lymphocyte syndrome, and homozygous knockout mice exhibit many features of this disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. "
---
> "P70196-1","NP_001290202.1","TNF receptor-associated factor 6","530","This gene encodes a member of the TNF receptor associated factor (TRAF) family of adaptor proteins that mediate signaling events from members of the TNF receptor and Toll/IL-1 receptor families to activate transcription factors such as NF-kappa-B and AP-1. The product of this gene is essential for perinatal and postnatal survival. Mice deficient in this protein exhibit osteopetrosis and defective in development of epidermal appendixes, normal B cell differentiation, lymph node organogenesis, interleukin-1 signaling, lipopolysaccharide signaling and neural tube closure. This protein possesses ubiquitin ligase activity. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]. "
10761d10731
< "P35639-1","NP_031863.3","DNA damage-inducible transcript 3 protein","168",""
10762a10733
> "O35717-1","NP_001162126.1","suppressor of cytokine signaling 2","198",""
10766a10738
> "P35583-1","NP_001277994.1","hepatocyte nuclear factor 3-beta isoform a","465",""
10769d10740
< "P70268-1","NP_796236.2","serine/threonine-protein kinase N1 isoform 2","946",""
10770a10742
> "Q64249-1","NP_001153020.1","nuclear receptor subfamily 6 group A member 1 isoform 2","438",""
10774a10747
> "Q8BG60-1","NP_001009935.1","thioredoxin-interacting protein isoform 1","397",""
10777c10750,10751
< "P53566-1","NP_031704.2","CCAAT/enhancer-binding protein alpha isoform a","359","This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. The use of alternative in-frame non-AUG (CUG) and AUG start codons results in several protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the CUG and the first AUG start codons. [provided by RefSeq, Sep 2014]. "
---
> "Q06180-1","NP_001120649.1","tyrosine-protein phosphatase non-receptor type 2 isoform b","406",""
> "P01193-1","NP_001265510.1","pro-opiomelanocortin preproprotein","235","This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing. Processing yields several biologically active peptides, which are involved in diverse cellular functions, such as energy homeostasis, steroidogenesis, and increased melanin production in melanocytes. In mouse deficiency of this gene is associated with obesity, defects in adrenal development, and altered pigmentation. A pseudogene of this gene is located on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]. "
10779d10752
< "P39428-1","NP_033447.2","TNF receptor-associated factor 1","409",""
10782,10783d10754
< "O70374-1","NP_766448.1","protein CBFA2T2 isoform 1","594",""
< "P05480-1","NP_033297.2","neuronal proto-oncogene tyrosine-protein kinase Src isoform 1","541",""
10784a10756,10757
> "Q6P069-1","NP_001074443.1","sorcin isoform 1","198",""
> "Q8R0I0-1","NP_001123985.1","angiotensin-converting enzyme 2 precursor","805",""
10786d10758
< "Q8VCK6-1","NP_666299.1","free fatty acid receptor 2","330",""
10789a10762
> "P49117-1","NP_001334271.1","nuclear receptor subfamily 2 group C member 2 isoform 1","629",""
10796c10769
< "Q08122-3","NP_033415.2","transducin-like enhancer protein 3 isoform 2","772",""
---
> "Q07279-1","NP_001289267.1","transcription factor NF-E2 45 kDa subunit","373",""
10797a10771
> "P56198-1","NP_001288224.1","cell death activator CIDE-3 isoform 1","239",""
10799c10773
< "Q8K445-1","NP_700435.1","clarin-1 isoform 3","172",""
---
> "Q08122-3","NP_001077396.1","transducin-like enhancer protein 3 isoform 1","782",""
10801a10776
> "O70374-1","NP_033953.1","protein CBFA2T2 isoform 2","593",""
10803,10804d10777
< "O08573-1","NP_034838.2","galectin-9 isoform 1","353",""
< "P49117-1","NP_035760.1","nuclear receptor subfamily 2 group C member 2 isoform 2","596",""
10806c10779
< "Q8R0I0-1","NP_081562.2","angiotensin-converting enzyme 2 precursor","805",""
---
> "Q9CWU5-1","NP_001298035.1","KH domain-containing protein 3 isoform 2","346",""
10810a10784,10785
> "P30987-1","NP_001264194.1","thromboxane A2 receptor","341","This gene encodes a multi-pass membrane protein that functions as a G-protein coupled receptor. The encoded protein binds thromboxane A2, resulting in the aggregation of platelets and constriction of blood vessels. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Mar 2013]. "
> "Q9Z103-1","NP_001297015.1","activity-dependent neuroprotector homeobox protein isoform 1","1108","This gene encodes a member of a protein family characterized by nine zinc finger motifs followed by a homeobox domain. In vitro studies demonstrate that the encoded protein interacts with the brahma-related gene1-associated or hBRM factors (BAF) gene expression regulating complex, components of the protein translation machinery, and microtubule-associated proteins. This gene has been implicated in neuroprotection through various processes that include chromatin remodeling, splicing, cytoskeletal reorganization, and autophagy. Homozygous mutant knockout mice display embryonic lethality with defects in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]. "
10812,10813c10787,10788
< "P97438-1","NP_034737.2","potassium channel subfamily K member 2 isoform 2","411",""
< "P56198-1","NP_848460.1","cell death activator CIDE-3 isoform 1","239",""
---
> "P97438-1","NP_001153322.1","potassium channel subfamily K member 2 isoform 1","426",""
> "Q8K445-1","NP_700433.1","clarin-1 isoform 1","250",""
10815a10791
> "P15656-1","NP_001264197.1","fibroblast growth factor 5 isoform 2 precursor","121","This gene encodes a secreted protein that is a member of a family of heparin-binding growth factors. The encoded protein regulates cell proliferation, particularly the growth of hair follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. "
10818c10794
< "P15656-1","NP_034333.1","fibroblast growth factor 5 isoform 1 precursor","264","This gene encodes a secreted protein that is a member of a family of heparin-binding growth factors. The encoded protein regulates cell proliferation, particularly the growth of hair follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. "
---
> "P46412-1","NP_001316789.1","glutathione peroxidase 3 isoform 2 precursor","258","The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted and is highly expressed in mouse kidney, which appears to be the major source of the enzyme in plasma. It has a role in mouse organogenesis, and dysregulation of this isozyme has been associated with obesity-related metabolic complications, platelet-dependent thrombosis, colitis-associated carcinoma, and thermosensitive phenotype. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2016]. "
10821,10823c10797
< "Q9Z103-1","NP_033758.2","activity-dependent neuroprotector homeobox protein isoform 1","1108","This gene encodes a member of a protein family characterized by nine zinc finger motifs followed by a homeobox domain. In vitro studies demonstrate that the encoded protein interacts with the brahma-related gene1-associated or hBRM factors (BAF) gene expression regulating complex, components of the protein translation machinery, and microtubule-associated proteins. This gene has been implicated in neuroprotection through various processes that include chromatin remodeling, splicing, cytoskeletal reorganization, and autophagy. Homozygous mutant knockout mice display embryonic lethality with defects in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]. "
< "Q6P069-1","NP_079894.2","sorcin isoform 2","183",""
< "P46412-1","NP_032187.2","glutathione peroxidase 3 isoform 1 precursor","226","The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted and is highly expressed in mouse kidney, which appears to be the major source of the enzyme in plasma. It has a role in mouse organogenesis, and dysregulation of this isozyme has been associated with obesity-related metabolic complications, platelet-dependent thrombosis, colitis-associated carcinoma, and thermosensitive phenotype. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2016]. "
---
> "P54254-1","NP_001186233.1","ataxin-1 isoform b","791",""
10826d10799
< "Q91W90-1","NP_663342.3","thioredoxin domain-containing protein 5 isoform 1 precursor","417",""
10828a10802
> "Q60760-1","NP_001171100.1","growth factor receptor-bound protein 10 isoform 2","541",""
10830d10803
< "P30987-1","NP_033351.1","thromboxane A2 receptor","341","This gene encodes a multi-pass membrane protein that functions as a G-protein coupled receptor. The encoded protein binds thromboxane A2, resulting in the aggregation of platelets and constriction of blood vessels. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Mar 2013]. "
10832a10806
> "Q8VCK6-1","NP_001161981.1","free fatty acid receptor 2","330",""
10834c10808,10809
< "Q9CWU5-1","NP_080166.1","KH domain-containing protein 3 isoform 1","440",""
---
> "Q80TQ2-1","NP_001121642.1","ubiquitin carboxyl-terminal hydrolase CYLD isoform a","955","This gene encodes a protein that is a member of the ubiquitin C-terminal hydrolase subfamily of the deubiquitinating enzyme family. Members of this family catalyze the removal of ubiquitin from a substrate or another ubiquitin molecule and thereby play important roles in regulating signaling pathways, recycling ubiquitin and regulating protein stability. This protein removes ubiquitin from K-63-linked ubiquitin chains from proteins involved in NF-kappaB signaling and thus acts as a negative regulator of this pathway. In humans mutations in this gene have been associated with cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. In mouse deficiency of this gene impairs thymocyte development and increases susceptibility to skin and colon tumors. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]. "
> "P50462-1","NP_001185770.1","cysteine and glycine-rich protein 3","194",""
10836d10810
< "Q9D0L1-1","NP_082382.1","zinc finger BED domain-containing protein 3","228","This gene encodes a member of the zinc finger protein superfamily. This protein may regulate the Wnt/beta-catenin signaling pathway. This protein may be involved in insulin resistance and type 2 diabetes in humans. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
10838d10811
< "P50462-1","NP_038836.1","cysteine and glycine-rich protein 3","194",""
10840c10813
< "Q78Y63-1","NP_075997.1","phosducin-like protein 2 isoform 1","240",""
---
> "P05480-1","NP_001020566.1","neuronal proto-oncogene tyrosine-protein kinase Src isoform 2","535",""
10843a10817
> "Q78Y63-1","NP_001297566.1","phosducin-like protein 2 isoform 2","192",""
10847d10820
< "Q80TQ2-1","NP_775545.1","ubiquitin carboxyl-terminal hydrolase CYLD isoform b","952","This gene encodes a protein that is a member of the ubiquitin C-terminal hydrolase subfamily of the deubiquitinating enzyme family. Members of this family catalyze the removal of ubiquitin from a substrate or another ubiquitin molecule and thereby play important roles in regulating signaling pathways, recycling ubiquitin and regulating protein stability. This protein removes ubiquitin from K-63-linked ubiquitin chains from proteins involved in NF-kappaB signaling and thus acts as a negative regulator of this pathway. In humans mutations in this gene have been associated with cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. In mouse deficiency of this gene impairs thymocyte development and increases susceptibility to skin and colon tumors. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]. "
10848a10822
> "Q91W90-1","NP_001276527.1","thioredoxin domain-containing protein 5 isoform 2","323",""
10852d10825
< "Q60760-1","NP_034475.2","growth factor receptor-bound protein 10 isoform 1","596",""
10861d10833
< "Q07279-1","NP_032711.2","transcription factor NF-E2 45 kDa subunit","373",""
10865,10866d10836
< "P54254-1","NP_033150.2","ataxin-1 isoform b","791",""
< "P01193-1","NP_032921.1","pro-opiomelanocortin preproprotein","235","This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing. Processing yields several biologically active peptides, which are involved in diverse cellular functions, such as energy homeostasis, steroidogenesis, and increased melanin production in melanocytes. In mouse deficiency of this gene is associated with obesity, defects in adrenal development, and altered pigmentation. A pseudogene of this gene is located on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]. "
10867a10838,10840
> "O08573-1","NP_001152773.1","galectin-9 isoform 2","322",""
> "P39428-1","NP_001313530.1","TNF receptor-associated factor 1","409",""
> "Q9D0L1-1","NP_001289467.1","zinc finger BED domain-containing protein 3","228","This gene encodes a member of the zinc finger protein superfamily. This protein may regulate the Wnt/beta-catenin signaling pathway. This protein may be involved in insulin resistance and type 2 diabetes in humans. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
10871a10845
> "Q9ESG6-1","NP_001008497.1","P2Y purinoceptor 14 isoform a","338",""
10872a10847
> "Q80UG5-1","NP_001106958.1","septin-9 isoform a","583",""
10875d10849
< "P84444-1","NP_035254.1","C-C motif chemokine 21a precursor","133",""
10878d10851
< "Q99MV1-1","NP_113564.2","tudor domain-containing protein 1","1172",""
10879a10853
> "Q9JJP2-1","NP_001119802.1","tumor protein p73 isoform b","590","This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq, Jul 2008]. "
10885a10860
> "O55203-1","NP_001070866.1","LIM domain-binding protein 2 isoform 2","329",""
10888c10863
< "Q61179-1","NP_032420.1","interferon regulatory factor 9 isoform 3","399",""
---
> "Q8R4G0-1","NP_001156820.1","netrin-G1 isoform b precursor","483",""
10893c10868,10870
< "Q80UG5-1","NP_059076.1","septin-9 isoform c","334",""
---
> "Q99MV1-1","NP_001002238.1","tudor domain-containing protein 1","1172",""
> "O08810-1","NP_001103465.1","116 kDa U5 small nuclear ribonucleoprotein component isoform b","972",""
> "Q149L7-1","NP_001268883.1","cytotoxic and regulatory T-cell molecule isoform 1 precursor","393",""
10896d10872
< "Q9WUH2-3","NP_034844.1","LIM/homeobox protein Lhx9 isoform b","321",""
10898d10873
< "O08791-1","NP_034226.1","transcription factor COE3 isoform 3","551",""
10902c10877
< "Q9Z218-1","NP_997165.2","dipeptidyl aminopeptidase-like protein 6 isoform 3","859",""
---
> "P48615-1","NP_001272721.1","protein Wnt-11 isoform a precursor","354",""
10904,10905d10878
< "Q811T9-1","NP_777279.2","disrupted in schizophrenia 1 homolog isoform 1","852",""
< "Q7TSY8-1","NP_950172.1","shugoshin 2 isoform 1","1164",""
10908d10880
< "Q9JMI0-1","NP_067281.2","endothelin-converting enzyme-like 1","775",""
10910c10882,10884
< "Q8C4H2-1","NP_001108626.1","sterile alpha motif domain-containing protein 3 isoform 2","514",""
---
> "Q61043-3","NP_001273008.1","ninein isoform 2","2035",""
> "Q3UWW6-1","NP_001028503.2","GAS2-like protein 3 isoform 1","683",""
> "Q9D394-1","NP_001276704.1","protein RUFY3 isoform 2","519",""
10913d10886
< "O55100-1","NP_997591.1","synaptogyrin-1 isoform 1a","234",""
10919c10892
< "P30875-1","NP_033243.2","somatostatin receptor type 2 isoform B","346","The protein encoded by this gene is a receptor for somatostatin, which acts at many sites to inhibit the release of several hormones and other secretory proteins. The encoded protein is a member of the superfamily of receptors having seven transmembrane segments and is involved in many processes, including adenylyl cyclase inhibition, phosphotyrosine phosphatase stimulation, and inhibition of calcium entry and cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
---
> "Q9WUH2-3","NP_001020736.1","LIM/homeobox protein Lhx9 isoform a","330",""
10921d10893
< "Q6ZPF3-1","NP_036008.2","T-lymphoma invasion and metastasis-inducing protein 2 isoform 1","1715",""
10923d10894
< "Q9WU42-1","NP_001240834.1","nuclear receptor corepressor 2 isoform 3","2253",""
10926c10897
< "Q9D1H9-1","NP_083844.1","microfibril-associated glycoprotein 4 isoform 2 precursor","257",""
---
> "Q7TSY8-1","NP_001171338.1","shugoshin 2 isoform 2","1064",""
10933d10903
< "Q8R4G0-1","NP_597995.1","netrin-G1 isoform e precursor","460",""
10937d10906
< "Q61312-1","NP_033361.2","transcription factor AP-2 gamma isoform 1","449",""
10939c10908
< "Q8BZM0-1","NP_694768.1","kelch-like protein 12 isoform 2","541",""
---
> "Q61312-1","NP_001153168.1","transcription factor AP-2 gamma isoform 2","488",""
10941a10911
> "Q99KJ5-1","NP_001157235.1","transcription factor 19-like protein","263",""
10944c10914
< "P51448-1","NP_038674.1","nuclear receptor ROR-alpha isoform 1","523","The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]. "
---
> "Q9Z218-1","NP_034205.1","dipeptidyl aminopeptidase-like protein 6 isoform 2","804",""
10946c10916
< "Q8BGN8-1","NP_082328.3","synaptoporin isoform 1","285",""
---
> "P70170-1","NP_001038185.1","ATP-binding cassette sub-family C member 9 isoform d","1533","The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015]. "
10948,10949c10918
< "Q8BX22-1","NP_958798.2","sal-like protein 4 isoform c","278","This gene belongs to the spalt family of zinc finger transcription factors. In mouse, functions for this gene have been described in many embryonic developmental processes, including brain, heart, and limb development. In addition, this gene is an important pluripotency factor that is required for stem cell maintenance. Homozygous mutant mice display embryonic lethality, while conditional knock-out in embryonic germ cells results in failure to establish a robust stem cell population. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
< "Q8BID6-1","NP_082401.1","zinc finger and BTB domain-containing protein 46 isoform 2","434",""
---
> "P33242-1","NP_001303616.1","steroidogenic factor 1","462",""
10954d10922
< "Q08874-1","NP_032627.1","microphthalmia-associated transcription factor isoform 2","419","This transcription factor serves at a critical point between extracellular signaling and downstream targets in cell specification in early eye and neural crest development. Mutant alleles have been identified that generate distinct phenotypes. Some of these alleles are being used to model the human diseases Waardenburg syndrome IIa and Tietz syndrome. [provided by RefSeq, Jul 2008]. "
10955a10924
> "O08791-1","NP_001106886.1","transcription factor COE3 isoform 1","596",""
10957,10960c10926,10929
< "O35368-1","NP_001289580.1","interferon-activable protein 203 isoform 3","409",""
< "Q9Z0T9-1","NP_067334.1","integrin beta-6 precursor","787",""
< "Q99KJ5-1","NP_079950.2","transcription factor 19-like protein","263",""
< "P70170-1","NP_066379.2","ATP-binding cassette sub-family C member 9 isoform c","1511","The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015]. "
---
> "Q99NH7-1","NP_001276716.1","prestin isoform 2","707",""
> "P09535-1","NP_001116208.1","insulin-like growth factor II isoform 2 preproprotein","180","This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. It is an imprinted gene that is expressed only from the paternal allele. The encoded protein undergoes proteolytic processing to generate a mature peptide. The transgenic overexpression of this gene in mice results in prenatal overgrowth, polyhydramnios, fetal and neonatal lethality, disproportionate organ overgrowth including tongue enlargement, and skeletal abnormalities. Mice lacking the encoded protein exhibit growth deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]. "
> "P30875-1","NP_001036071.1","somatostatin receptor type 2 isoform A","369","The protein encoded by this gene is a receptor for somatostatin, which acts at many sites to inhibit the release of several hormones and other secretory proteins. The encoded protein is a member of the superfamily of receptors having seven transmembrane segments and is involved in many processes, including adenylyl cyclase inhibition, phosphotyrosine phosphatase stimulation, and inhibition of calcium entry and cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
> "Q8R5F7-1","NP_001157949.1","interferon-induced helicase C domain-containing protein 1 isoform 2","976",""
10962,10963c10931
< "Q9D394-1","NP_081806.1","protein RUFY3 isoform 4","469",""
< "O35973-1","NP_035195.2","period circadian protein homolog 1","1291","This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]. "
---
> "O88533-1","NP_001177377.1","aromatic-L-amino-acid decarboxylase","480",""
10964a10933
> "P48302-1","NP_001129533.1","endothelin receptor type B precursor","442","This gene encodes a member of the G-protein coupled receptor family. It encodes a receptor for endothelins, peptides that are involved in vasocontriction. The encoded protein activates a phosphatidylinositol-calcium second messenger system and is required for the development of enteric neurons and melanocytes. Gene disruption causes pigmentation anomalies, deafness, and abnormal dilation of the colon due to defects of neural crest-derived cells. Mutations in this gene are found in the piebald mouse, and mouse models of Hirschsprung's disease and Waardenburg syndrome type 4. Renal collecting duct-specific gene deletion causes sodium retention and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
10970,10971c10939
< "P97785-1","NP_034409.1","GDNF family receptor alpha-1 isoform 1 preproprotein","468","This gene encodes a transmembrane protein that functions as the receptor for glial cell line derived neurotrophic factor (GDNF). The encoded protein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-anchored cell surface coreceptor that forms a complex with the Ret tyrosine kinase in GDNF signaling pathway. Mice lacking the encoded protein exhibit deficits in the kidneys, the enteric nervous system, and spinal motor and sensory neurons similar mice deficient in GDNF or Ret. [provided by RefSeq, Jul 2016]. "
< "P33242-1","NP_620639.1","steroidogenic factor 1","462",""
---
> "Q9D1H9-1","NP_001334474.1","microfibril-associated glycoprotein 4 isoform 1 precursor","281",""
10973a10942
> "P22005-1","NP_001002927.1","proenkephalin-A precursor","268",""
10974a10944
> "Q6ZPF3-1","NP_001116470.1","T-lymphoma invasion and metastasis-inducing protein 2 isoform 1","1715",""
10976c10946
< "Q9ESD7-1","NP_067444.2","dysferlin isoform 1","2100",""
---
> "Q6P1I6-1","NP_001276531.1","PH and SEC7 domain-containing protein 2 isoform 2","767",""
10980d10949
< "Q6P1I6-1","NP_082983.3","PH and SEC7 domain-containing protein 2","770",""
10986a10956
> "Q8BX22-1","NP_780512.2","sal-like protein 4 isoform a","1067","This gene belongs to the spalt family of zinc finger transcription factors. In mouse, functions for this gene have been described in many embryonic developmental processes, including brain, heart, and limb development. In addition, this gene is an important pluripotency factor that is required for stem cell maintenance. Homozygous mutant mice display embryonic lethality, while conditional knock-out in embryonic germ cells results in failure to establish a robust stem cell population. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
10995a10966
> "Q8BGN8-1","NP_001156504.1","synaptoporin isoform 2 precursor","265",""
10998a10970,10971
> "O55100-1","NP_033329.1","synaptogyrin-1 isoform 1b","191",""
> "P04184-1","NP_001258658.1","thymidine kinase, cytosolic isoform 2","197",""
11000d10972
< "P35383-1","NP_032799.2","P2Y purinoceptor 2","373",""
11004c10976,10978
< "P68404-1","NP_032881.1","protein kinase C beta type isoform 1","673",""
---
> "Q9R1X4-1","NP_001129554.1","protein timeless homolog isoform 1","1196","The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]. "
> "P35383-1","NP_001289275.1","P2Y purinoceptor 2","373",""
> "Q8BZM0-1","NP_001298065.1","kelch-like protein 12 isoform 1","568",""
11006,11007c10980,10981
< "P04184-1","NP_033413.2","thymidine kinase, cytosolic isoform 1","233",""
< "Q99NH7-1","NP_109652.3","prestin isoform 1","744",""
---
> "Q9QYR6-1","NP_001166977.1","microtubule-associated protein 1A isoform 2","2776",""
> "Q8C4H2-1","NP_001013788.2","sterile alpha motif domain-containing protein 3 isoform 1","273",""
11012d10985
< "Q61043-3","NP_001074922.1","ninein isoform 1","2113",""
11014c10987
< "Q9QYR6-1","NP_115769.1","microtubule-associated protein 1A isoform 1","3014",""
---
> "P70390-1","NP_001289286.1","short stature homeobox protein 2 isoform 2","319",""
11018a10992,10993
> "Q8VI56-1","NP_001139329.1","low-density lipoprotein receptor-related protein 4 isoform 2 precursor","519",""
> "Q8BID6-1","NP_081932.1","zinc finger and BTB domain-containing protein 46 isoform 1","600",""
11019a10995
> "O35368-1","NP_001289578.1","interferon-activable protein 203 isoform 1","871",""
11020a10997
> "Q811T9-1","NP_777278.2","disrupted in schizophrenia 1 homolog isoform 2","789",""
11023a11001
> "Q61179-1","NP_001152889.1","interferon regulatory factor 9 isoform 1","465",""
11029a11008
> "P68404-1","NP_001303601.1","protein kinase C beta type isoform 2","671",""
11031d11009
< "Q3UHD6-1","NP_083997.1","sorting nexin-27 isoform 2","526",""
11036a11015
> "Q61473-1","NP_001276393.1","transcription factor SOX-17 isoform a","419","This gene encodes a member of the Sox (Sry-related high mobility group box) family of transcription factors involved in the regulation of embryonic development. The encoded protein plays a role in the determination of cell fate and in maintaining cell identity. This gene regulates tumor angiogenesis and tumor progression. Mutations in the human gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. "
11038a11018
> "P22605-1","NP_001276689.1","retinoic acid receptor beta isoform beta3","482",""
11040,11041c11020
< "Q61473-1","NP_035571.1","transcription factor SOX-17 isoform a","419","This gene encodes a member of the Sox (Sry-related high mobility group box) family of transcription factors involved in the regulation of embryonic development. The encoded protein plays a role in the determination of cell fate and in maintaining cell identity. This gene regulates tumor angiogenesis and tumor progression. Mutations in the human gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. "
< "Q91ZM9-1","NP_084037.3","docking protein 5 isoform 1","306",""
---
> "O35973-1","NP_001152839.1","period circadian protein homolog 1","1291","This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]. "
11045d11023
< "P22605-1","NP_035373.1","retinoic acid receptor beta isoform beta2","448",""
11049c11027
< "P05977-1","NP_067260.1","myosin light chain 1/3, skeletal muscle isoform isoform 1f","188","Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two non-phosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. "
---
> "Q60898-1","NP_001025012.1","src-like-adapter isoform a","297",""
11051a11030
> "P05977-1","NP_001106858.1","myosin light chain 1/3, skeletal muscle isoform isoform 3f","150","Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two non-phosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. "
11057d11035
< "Q60898-1","NP_033218.1","src-like-adapter isoform b","281",""
11058a11037
> "Q08874-1","NP_001106669.1","microphthalmia-associated transcription factor isoform 1","526","This transcription factor serves at a critical point between extracellular signaling and downstream targets in cell specification in early eye and neural crest development. Mutant alleles have been identified that generate distinct phenotypes. Some of these alleles are being used to model the human diseases Waardenburg syndrome IIa and Tietz syndrome. [provided by RefSeq, Jul 2008]. "
11059a11039
> "P97785-1","NP_001272386.1","GDNF family receptor alpha-1 isoform 2 precursor","463","This gene encodes a transmembrane protein that functions as the receptor for glial cell line derived neurotrophic factor (GDNF). The encoded protein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-anchored cell surface coreceptor that forms a complex with the Ret tyrosine kinase in GDNF signaling pathway. Mice lacking the encoded protein exhibit deficits in the kidneys, the enteric nervous system, and spinal motor and sensory neurons similar mice deficient in GDNF or Ret. [provided by RefSeq, Jul 2016]. "
11061,11062d11040
< "O88533-1","NP_057881.1","aromatic-L-amino-acid decarboxylase","480",""
< "Q8VI56-1","NP_766256.3","low-density lipoprotein receptor-related protein 4 isoform 1 precursor","1905",""
11064a11043
> "Q9WU42-1","NP_001240833.1","nuclear receptor corepressor 2 isoform 2","2332",""
11067d11045
< "P48302-1","NP_031930.1","endothelin receptor type B precursor","442","This gene encodes a member of the G-protein coupled receptor family. It encodes a receptor for endothelins, peptides that are involved in vasocontriction. The encoded protein activates a phosphatidylinositol-calcium second messenger system and is required for the development of enteric neurons and melanocytes. Gene disruption causes pigmentation anomalies, deafness, and abnormal dilation of the colon due to defects of neural crest-derived cells. Mutations in this gene are found in the piebald mouse, and mouse models of Hirschsprung's disease and Waardenburg syndrome type 4. Renal collecting duct-specific gene deletion causes sodium retention and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
11069a11048
> "Q9Z0T9-1","NP_001153036.1","integrin beta-6 precursor","787",""
11074d11052
< "O55203-1","NP_034828.3","LIM domain-binding protein 2 isoform 1","373",""
11084d11061
< "O08810-1","NP_035561.1","116 kDa U5 small nuclear ribonucleoprotein component isoform a","971",""
11087c11064,11065
< "P48615-1","NP_033545.1","protein Wnt-11 isoform a precursor","354",""
---
> "Q9ESD7-1","NP_001071162.1","dysferlin isoform 2","2099",""
> "Q91ZM9-1","NP_001157158.1","docking protein 5 isoform 2","304",""
11091,11095c11069,11071
< "Q8R5F7-1","NP_082111.2","interferon-induced helicase C domain-containing protein 1 isoform 1","1025",""
< "Q9ESG6-1","NP_573463.1","P2Y purinoceptor 14 isoform a","338",""
< "P09535-1","NP_034644.2","insulin-like growth factor II isoform 1 precursor","191","This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. It is an imprinted gene that is expressed only from the paternal allele. The encoded protein undergoes proteolytic processing to generate a mature peptide. The transgenic overexpression of this gene in mice results in prenatal overgrowth, polyhydramnios, fetal and neonatal lethality, disproportionate organ overgrowth including tongue enlargement, and skeletal abnormalities. Mice lacking the encoded protein exhibit growth deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]. "
< "Q149L7-1","NP_062338.3","cytotoxic and regulatory T-cell molecule isoform 2 precursor","392",""
< "P70390-1","NP_038693.1","short stature homeobox protein 2 isoform 1","331",""
---
> "Q9JMI0-1","NP_001264854.1","endothelin-converting enzyme-like 1","775",""
> "Q3UHD6-1","NP_001075953.1","sorting nexin-27 isoform 1","539",""
> "P51448-1","NP_001276845.1","nuclear receptor ROR-alpha isoform 2","467","The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]. "
11098d11073
< "Q9R1X4-1","NP_035719.1","protein timeless homolog isoform 2","1197","The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]. "
11108d11082
< "Q18PE0-1","NP_001335407.1","protein Dok-7 isoform 1","607",""
11113c11087
< "P46061-1","NP_035371.4","ran GTPase-activating protein 1 isoform 1","589",""
---
> "Q9ET78-1","NP_001192005.1","junctophilin-2","696",""
11115,11116d11088
< "Q91WW4-1","NP_694741.2","mas-related G-protein coupled receptor member A2","331",""
< "Q8BI36-1","NP_077167.1","JNK1/MAPK8-associated membrane protein isoform 1","311",""
11124a11097,11099
> "Q3U4H6-1","NP_001001333.2","hexosaminidase D isoform 2","486",""
> "Q8VBT9-1","NP_001157696.1","tether containing UBX domain for GLUT4 isoform 3","452",""
> "Q9JKB3-1","NP_035863.1","Y-box-binding protein 3 short isoform","292",""
11125a11101,11102
> "Q6WKZ8-1","NP_001170845.1","E3 ubiquitin-protein ligase UBR2 isoform 2","1755",""
> "Q8BW72-1","NP_001155295.1","lysine-specific demethylase 4A isoform 1","1064",""
11128a11106,11107
> "Q01768-1","NP_001070997.1","nucleoside diphosphate kinase B","152",""
> "Q9WVP1-1","NP_001103770.1","AP-1 complex subunit mu-2 isoform 1","425",""
11135a11115,11116
> "Q61464-1","NP_001159843.1","zinc finger protein 638 isoform 2","1271",""
> "Q9QZQ8-1","NP_001152985.1","core histone macro-H2A.1 isoform 2","371","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015]. "
11138d11118
< "P53811-1","NP_062614.1","phosphatidylinositol transfer protein beta isoform isoform 2","271","This gene encodes a member of the phosphatidylinositol transfer protein family. The encoded protein catalyzes the transfer of phospholipids (phosphatidylinositol and phosphatidylcholine) between membranes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. "
11140,11141c11120
< "Q8BIF0-1","NP_612182.1","CD99 antigen-like protein 2 isoform 2 precursor","214",""
< "Q80TM6-1","NP_082176.4","R3H domain-containing protein 2 isoform 2","999",""
---
> "Q9EQF5-1","NP_001157938.1","dihydropyrimidinase","519",""
11147,11148d11125
< "P97411-1","NP_034622.3","islet cell autoantigen 1 isoform 1","478",""
< "Q5U465-1","NP_898938.4","coiled-coil domain-containing protein 125 isoform A","500",""
11149a11127
> "Q921C3-1","NP_001096649.1","bromodomain and WD repeat-containing protein 1 isoform B","2259",""
11151c11129
< "P40237-1","NP_031682.1","CD82 antigen","266",""
---
> "Q8CCE9-1","NP_001288713.1","transcription factor E4F1 isoform 1","783","This gene encodes a member of the GLI-Kruppel zinc finger family. The encoded protein is likely to be multi-functional, with both adenovirus E1A-regulated transcription factor and ubiquitin E3 ligase activities, including roles in cell cycle regulation and the ubiquitination of p53. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. "
11154d11131
< "O54962-1","NP_035923.1","barrier-to-autointegration factor","89",""
11157a11135
> "P61213-1","NP_001034604.1","ADP-ribosylation factor-like protein 4A","200",""
11163c11141
< "P55098-1","NP_033020.2","peroxisome biogenesis factor 2","305",""
---
> "O70494-1","NP_001018052.1","transcription factor Sp3 isoform 1","783","This gene product belongs to a family of Sp1 related transcription factors, which regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses transcription of numerous genes. Alternative splicing results in transcript variants encoding different isoforms, and one variant initiates translation from a non-AUG (AUA) codon. [provided by RefSeq, Jul 2008]. "
11164a11143,11144
> "Q9D1F4-1","NP_001240849.1","proline-rich AKT1 substrate 1 isoform b","257",""
> "P61804-1","NP_001106829.1","dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1","113",""
11167c11147
< "Q9DBU5-1","NP_083050.1","E3 ubiquitin-protein ligase RNF6 isoform 1","667",""
---
> "P46061-1","NP_001139646.1","ran GTPase-activating protein 1 isoform 1","589",""
11169d11148
< "Q64127-1","NP_659542.3","transcription intermediary factor 1-alpha isoform 1","1051","The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which are typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. This protein, which also contains a PHD/TTC finger and bromodomain important for regulating nuclear receptors and binding chromatin, has important roles in differentiation, development, and tissue homeostasis. This protein has been reported to regulate the activity of the tumor suppressor p53 and of the retinoic acid receptor. A translocation event between this gene and Braf transforming gene, which results in the fusion protein T18, has been reported in hepatocellular carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]. "
11173d11151
< "O88998-1","NP_001033703.1","noelin isoform d precursor","125",""
11174a11153
> "Q62406-1","NP_001171445.1","interleukin-1 receptor-associated kinase 1 isoform 4","710",""
11178c11157,11158
< "Q8CCE9-1","NP_031919.2","transcription factor E4F1 isoform 2","782","This gene encodes a member of the GLI-Kruppel zinc finger family. The encoded protein is likely to be multi-functional, with both adenovirus E1A-regulated transcription factor and ubiquitin E3 ligase activities, including roles in cell cycle regulation and the ubiquitination of p53. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. "
---
> "Q08639-1","NP_001278694.1","transcription factor Dp-1 isoform a","410",""
> "P97931-1","NP_001035781.1","uracil-DNA glycosylase isoform a","306",""
11180c11160,11161
< "Q9ET78-1","NP_067541.1","junctophilin-2","696",""
---
> "O08609-1","NP_001152856.1","max-like protein X isoform alpha","214",""
> "P98084-1","NP_001278095.1","amyloid-beta A4 precursor protein-binding family A member 2","750",""
11183,11184d11163
< "Q9QYI5-3","NP_835156.1","dnaJ homolog subfamily B member 2 isoform 2","277",""
< "Q9JJ69-1","NP_663750.1","Kv channel-interacting protein 2 isoform c","220","This gene encodes a member of the voltage-gated potassium channel-interacting protein (KCNIP) family. KCNIP family members are small calcium binding proteins that commonly exhibit unique variation at their N-termini, and which modulate A-type potassium channels. This gene is predominantly expressed in the adult heart, and to a lesser extent in the brain. Disruption of this gene is associated with susceptibility to cardiac arrhythmias and lack of transient outward potassium current in ventricular myocytes, and downregulated expression is associated with cardiac hypertrophy. The encoded protein has also been implicated as a repressor of immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]. "
11188a11168
> "Q60654-1","NP_001103793.1","killer cell lectin-like receptor 7 isoform 1","280",""
11192d11171
< "Q8BZ03-1","NP_849231.1","serine/threonine-protein kinase D2","875",""
11197,11198d11175
< "Q99MP8-1","NP_082503.2","BRCA1-associated protein isoform 1","591",""
< "Q8BKX1-1","NP_570932.2","brain-specific angiogenesis inhibitor 1-associated protein 2 isoform b","522",""
11201a11179
> "Q8K3P1-1","NP_001158305.1","P2X purinoceptor 2 isoform b","416",""
11205,11206d11182
< "O08609-1","NP_035680.3","max-like protein X isoform gamma","298",""
< "Q3V188-1","NP_032928.1","poly(U)-specific endoribonuclease isoform 1","454",""
11210c11186
< "Q62219-1","NP_001276482.1","transforming growth factor beta-1-induced transcript 1 protein isoform d","350",""
---
> "Q9QX11-1","NP_001106169.1","cytohesin-1 isoform 2","397",""
11213,11214c11189
< "Q8BH60-1","NP_444417.2","Golgi-associated PDZ and coiled-coil motif-containing protein isoform b","455",""
< "P0DOV1-1","NP_001288674.1","interferon-activable protein 205-B isoform 2","423","The protein encoded by this gene is a member of the interferon-regulated 200 family of proteins, which contain an N-terminal pyrin domain that is proposed to function in cell death and a partially conserved 220 amino acid domain. Expression of this protein in embryonic stem cells is critical for the DNA damage response and regulation of cell survival. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]. "
---
> "Q8CE22-1","NP_001103797.1","cyclin-D-binding Myb-like transcription factor 1 isoform 2","691",""
11216a11192,11193
> "Q60722-1","NP_001077436.1","transcription factor 4 isoform b","666",""
> "P25425-1","NP_035267.2","POU domain, class 2, transcription factor 1 isoform A","793",""
11217a11195
> "Q03526-1","NP_001268894.1","tyrosine-protein kinase ITK/TSK isoform 1","625",""
11223d11200
< "Q6GYP7-1","NP_064378.4","ral GTPase-activating protein subunit alpha-1 isoform 2","2035",""
11227d11203
< "Q8K4J0-1","NP_783614.1","protein artemis isoform 2","603","This gene encodes a member of the SNM1 family of nucleases and is involved in V(D)J recombination and DNA repair. This protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Homozygous knockout mice for this gene exhibit severe combined immunodeficiency with sensitivity to ionizing radiation. Mutations in this gene in humans can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]. "
11228a11205,11207
> "Q9ER69-1","NP_001107004.1","pre-mRNA-splicing regulator WTAP isoform b","151",""
> "P0DPD9-1","NP_808809.1","Eef1akmt4-Ece2 readthrough isoform b","881","This locus represents naturally occurring readthrough transcription between the adjacent genes eukaryotic translation elongation factor 1 alpha lysine specific methyltransferase 4 (GeneID:110599566) and endothelin converting enzyme 2 (GeneID:107522). The readthrough transcript representing this gene encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jul 2017]. "
> "P0DOV1-1","NP_001028622.1","interferon-activable protein 205-B isoform 1","425","The protein encoded by this gene is a member of the interferon-regulated 200 family of proteins, which contain an N-terminal pyrin domain that is proposed to function in cell death and a partially conserved 220 amino acid domain. Expression of this protein in embryonic stem cells is critical for the DNA damage response and regulation of cell survival. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]. "
11230,11231d11208
< "Q9QZM8-1","NP_056611.2","F-box only protein 17 isoform 1","286",""
< "Q7TSC1-1","NP_064411.2","protein PRRC2A isoform 1","2158",""
11238d11214
< "Q9D1F4-1","NP_080546.1","proline-rich AKT1 substrate 1 isoform b","257",""
11241a11218,11219
> "Q5XPT3-1","NP_001160105.1","LARGE xylosyl- and glucuronyltransferase 2 isoform 2 precursor","655",""
> "Q64127-1","NP_001258993.1","transcription intermediary factor 1-alpha isoform 2","1017","The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which are typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. This protein, which also contains a PHD/TTC finger and bromodomain important for regulating nuclear receptors and binding chromatin, has important roles in differentiation, development, and tissue homeostasis. This protein has been reported to regulate the activity of the tumor suppressor p53 and of the retinoic acid receptor. A translocation event between this gene and Braf transforming gene, which results in the fusion protein T18, has been reported in hepatocellular carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]. "
11244c11222
< "Q9JKB3-1","NP_620817.2","Y-box-binding protein 3 long isoform","361",""
---
> "P70451-1","NP_001033086.2","tyrosine-protein kinase Fer isoform a","823",""
11248d11225
< "Q8R4Y0-1","NP_835459.1","Fc receptor-like protein 1 isoform 2 precursor","343",""
11253c11230
< "Q9DBT5-1","NP_083055.1","AMP deaminase 2 isoform b","798",""
---
> "Q9DBT5-1","NP_001276648.1","AMP deaminase 2 isoform b","798",""
11256,11257c11233
< "Q8BNV1-1","NP_001182134.1","tRNA (uracil-5-)-methyltransferase homolog A isoform 4","574",""
< "P61804-1","NP_034145.1","dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1","113",""
---
> "P98203-1","NP_001258957.1","armadillo repeat protein deleted in velo-cardio-facial syndrome homolog isoform 1","962",""
11259a11236
> "O88998-1","NP_001033701.1","noelin isoform b precursor","153",""
11263d11239
< "Q9JLC6-1","NP_705617.2","thyrotroph embryonic factor isoform 2","285",""
11265c11241
< "P21129-1","NP_663381.1","P3 protein","473",""
---
> "Q9EPX5-1","NP_001002846.1","F-box/LRR-repeat protein 12 isoform b","273",""
11268,11269c11244
< "P97931-1","NP_035807.2","uracil-DNA glycosylase isoform b","295",""
< "Q6IQX8-1","NP_081524.2","zinc finger protein 219 isoform 1","726",""
---
> "Q99MP8-1","NP_001276473.1","BRCA1-associated protein isoform 3","561",""
11271c11246
< "Q7TNV1-1","NP_084254.1","ceramide synthase isoform 1","275",""
---
> "Q64092-1","NP_001098666.1","transcription factor E3 isoform b","537",""
11275d11249
< "P61213-1","NP_031513.1","ADP-ribosylation factor-like protein 4A","200",""
11277c11251,11252
< "Q9Z351-1","NP_034741.2","potassium voltage-gated channel subfamily KQT member 2 isoform 1","870",""
---
> "Q61214-1","NP_001106860.1","dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1","763",""
> "P82343-1","NP_001158176.1","N-acylglucosamine 2-epimerase isoform 2","416",""
11279a11255
> "Q7TNV1-1","NP_001139819.1","ceramide synthase isoform 3","225",""
11282a11259
> "P28659-1","NP_001231820.1","CUGBP Elav-like family member 1 isoform 2","486",""
11287a11265
> "Q9JJ69-1","NP_001263287.1","Kv channel-interacting protein 2 isoform d","225","This gene encodes a member of the voltage-gated potassium channel-interacting protein (KCNIP) family. KCNIP family members are small calcium binding proteins that commonly exhibit unique variation at their N-termini, and which modulate A-type potassium channels. This gene is predominantly expressed in the adult heart, and to a lesser extent in the brain. Disruption of this gene is associated with susceptibility to cardiac arrhythmias and lack of transient outward potassium current in ventricular myocytes, and downregulated expression is associated with cardiac hypertrophy. The encoded protein has also been implicated as a repressor of immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]. "
11292a11271,11272
> "Q5U465-1","NP_001161858.1","coiled-coil domain-containing protein 125 isoform B","330",""
> "O35484-1","NP_001095928.1","antizyme inhibitor 1 isoform 1","448","The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]. "
11294d11273
< "Q91Y44-1","NP_473395.2","bromodomain testis-specific protein isoform A","956","The protein encoded by this gene belongs to the BET protein family. BET proteins have two N-terminal bromodomains and one C-terminal extraterminal domain (ET domain). BET proteins regulate chromatin reorganization via binding to acetylated histones. This gene is thought to play a role in the transcriptional regulation of spermatogenesis. Although referred to as testis-specific bromodomain (Brdt) protein, RT-PCR indicates that this gene is expressed in both mouse oocytes and testes. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]. "
11296d11274
< "Q99PP2-1","NP_997554.2","zinc finger protein 318 isoform 1","2237",""
11298d11275
< "P35802-1","NP_705809.1","neuronal membrane glycoprotein M6-a isoform 1","278",""
11301d11277
< "Q80W68-1","NP_570937.2","kin of IRRE-like protein 1 precursor","789",""
11302a11279,11280
> "Q9CWE0-1","NP_001243041.1","mitochondrial fission regulator 1-like","289",""
> "Q8R4Y0-1","NP_001129708.1","Fc receptor-like protein 1 isoform 3 precursor","300",""
11304d11281
< "P41971-1","NP_038536.2","ETS domain-containing protein Elk-3 isoform Elk3","409",""
11306,11307c11283
< "Q5SVQ0-1","NP_808287.1","histone acetyltransferase KAT7 isoform 3","522",""
< "P48542-1","NP_034736.2","G protein-activated inward rectifier potassium channel 2 isoform Girk2A-1","425",""
---
> "Q80XQ2-1","NP_001272922.1","TBC1 domain family member 5 isoform b","815",""
11309d11284
< "Q6ZPI0-1","NP_758507.3","protein Jade-1","834",""
11311c11286
< "Q01768-1","NP_032731.1","nucleoside diphosphate kinase B","152",""
---
> "Q9JLB0-1","NP_001158205.1","MAGUK p55 subfamily member 6 isoform a","553",""
11315a11291,11292
> "Q61532-1","NP_056621.4","mitogen-activated protein kinase 6","720",""
> "Q80U58-1","NP_001153691.1","pumilio homolog 2 isoform 1","1066",""
11317d11293
< "Q91X88-1","NP_084062.2","protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 isoform 2","627",""
11321d11296
< "Q5HZI1-1","NP_001273342.1","microtubule-associated tumor suppressor 1 homolog isoform 1","1210",""
11327a11303,11304
> "Q9JLC6-1","NP_059072.1","thyrotroph embryonic factor isoform 1","301",""
> "Q80WQ6-1","NP_001161152.1","inactive rhomboid protein 2","827",""
11329a11307
> "Q9D067-1","NP_001156376.1","nuclear protein MDM1 isoform 3","718",""
11331a11310,11311
> "Q80W68-1","NP_001164456.1","kin of IRRE-like protein 1 precursor","789",""
> "Q9Z0L2-1","NP_001271120.1","artemin isoform 1 preproprotein","224","This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Mice lacking a functional copy of this gene exhibit ptosis and impaired development of the sympathetic nervous system. [provided by RefSeq, Aug 2016]. "
11334d11313
< "Q8BVP5-1","NP_598763.1","casein kinase I isoform gamma-2 isoform 1","442",""
11336,11338c11315
< "Q9CZ62-1","NP_083091.1","centrosomal protein of 97 kDa isoform 1","856",""
< "Q3UHC7-1","NP_001277570.1","disabled homolog 2-interacting protein isoform 6","1065",""
< "Q8BK26-1","NP_775577.2","F-box only protein 44 isoform 1","255",""
---
> "Q9WTJ6-1","NP_001034746.1","tesmin isoform a","475",""
11340d11316
< "O89033-1","NP_035929.1","cell division control protein 6 homolog isoform a","589",""
11342a11319
> "P97792-1","NP_001020363.1","coxsackievirus and adenovirus receptor homolog isoform a precursor","365","This gene encodes a protein that is part of the Cortical Thymocyte marker in Xenopus (CTX) subfamily within the immunoglobulin superfamily. Members of this subfamily, predominantly expressed on the surface of endothelial and epithelial cells, help establish cell polarity and provide a barrier function, regulating migration of immune cells. This protein, first identified as the receptor for adenovirus subgroup C and coxsakieviruses group B, is developmentally regulated and plays an important role in cardiac development. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]. "
11346,11347c11323,11324
< "Q03146-1","NP_766550.1","epithelial discoidin domain-containing receptor 1 isoform 2 precursor","874",""
< "Q8CE22-1","NP_035936.3","cyclin-D-binding Myb-like transcription factor 1 isoform 1","761",""
---
> "Q6ZPI0-1","NP_001123656.1","protein Jade-1","834",""
> "Q811D0-1","NP_001239362.1","disks large homolog 1 isoform 2","893",""
11349,11350d11325
< "Q9CWK3-1","NP_081629.1","CD2 antigen cytoplasmic tail-binding protein 2","342",""
< "Q5RKZ7-1","NP_082740.1","molybdenum cofactor biosynthesis protein 1 isoform 2","385",""
11351a11327
> "Q925T6-1","NP_001264221.1","glutamate receptor-interacting protein 1 isoform 4","1061","This gene encodes a protein containing multiple PDZ (post synaptic density protein, Drosophila disc large tumor suppressor, and zonula occludens-1 protein) domains. The encoded protein acts as a mediator between cytoskeletal and membrane proteins, particularly in neuronal cells, and facilitates complex formation at the cell membrane. Mutation of this gene can cause embryonic lethality resulting from defects of the dermo-epidermal junction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. "
11353,11354c11329,11331
< "Q9D020-3","NP_080280.3","cytosolic 5'-nucleotidase 3A isoform 1","331",""
< "Q9D0E1-1","NP_084080.1","heterogeneous nuclear ribonucleoprotein M isoform a","729",""
---
> "Q9DBN5-1","NP_001162063.1","lon protease homolog 2, peroxisomal isoform 2","432",""
> "Q9DC04-3","NP_001075119.1","regulator of G-protein signaling 3 isoform 3","433",""
> "Q61818-1","NP_001032853.1","retinoic acid-induced protein 1","1889",""
11357,11359d11333
< "Q08879-1","NP_034310.2","fibulin-1 isoform 1 precursor","705",""
< "P16305-1","NP_032094.2","gamma-aminobutyric acid receptor subunit alpha-6 isoform 2 precursor","443",""
< "Q5XPT3-1","NP_766258.2","LARGE xylosyl- and glucuronyltransferase 2 isoform 1 precursor","690",""
11366a11341
> "Q9EQH7-1","NP_001280611.1","bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform 2","458",""
11368,11369d11342
< "O88879-1","NP_033814.2","apoptotic protease-activating factor 1 isoform 1","1249",""
< "Q99K01-1","NP_444411.2","pyridoxal-dependent decarboxylase domain-containing protein 1 isoform 1","787",""
11373c11346
< "Q9D2N4-1","NP_034217.2","dystrobrevin alpha isoform f","371",""
---
> "Q2PFD7-1","NP_081902.1","PH and SEC7 domain-containing protein 3 isoform 3","376",""
11377d11349
< "Q3UJB9-1","NP_853625.1","enhancer of mRNA-decapping protein 4 isoform 2","1390","The protein encoded by this gene is thought to promote mRNA decay, and is known to interact with several mRNA decapping proteins. In humans, decreased expression of this gene prevents the accumulation of mRNA decapping proteins to mRNA processing bodies (P-body). Alternative splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]. "
11380c11352
< "P63213-1","NP_034445.1","guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor","71",""
---
> "Q9D304-1","NP_001241690.1","E3 ubiquitin-protein ligase RNF128 isoform 2 precursor","402",""
11381a11354,11356
> "Q5SVQ0-1","NP_001181933.1","histone acetyltransferase KAT7 isoform 2","581",""
> "P54265-1","NP_001177420.1","myotonin-protein kinase isoform 3","537","The protein encoded by this gene is a serine/threonine protein kinase that contains coiled-coil and C-terminal membrane association domains. In the embryonic mouse, it is found in cardiac and skeletal myocytes where it appears to play a role in myogenesis. In adults, the transcript is localized to several tissues including brain, heart, and skeletal and smooth muscle, and a function in cytoskeletal remodeling has been described. Transcripts with expanded CUG repeats in the 3' untranslated region mediate alternative splicing of several genes and sequester RNA binding proteins and RNA transcripts that contain CAG repeats, resulting in myotonic dystrophy, an autosomal dominant neuromuscular disorder. Alternative splicing results in multiple protein coding and non-coding transcript variants. [provided by RefSeq, Oct 2014]. "
> "Q65Z40-1","NP_001004436.2","wings apart-like protein homolog isoform 1","1200","Studies suggest that the protein encoded by this gene is important for the release of cohesin from chromatin. This gene product is thought to be essential for development, and reduced expression of this gene in cells causes defects in chromatin structure. High levels of expression of the human ortholog of this gene are observed in cervical cancers, and expression of the human ortholog of this gene in mice results in tumor formation. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Aug 2014]. "
11386d11360
< "P17426-1","NP_031484.1","AP-2 complex subunit alpha-1 isoform a","977",""
11388c11362,11364
< "O35347-1","NP_034177.1","protein DGCR6 isoform 3","170","This gene encodes a protein that is similar to the gonadal protein in Drosophila (fruit fly). The encoded protein is thought to play a role in migration of neural crest cells during development. Deletions in the human gene are associated with DiGeorge syndrome (or velocardiofacial syndrome) which has many clinical features including cardiac abnormalities, cleft palate, atypical facial features, hypocalcemia, hypoparathyroidism and defective development or congenital absence of the thymus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. "
---
> "P11416-1","NP_001169999.1","retinoic acid receptor alpha isoform 2","459",""
> "Q9JLN6-1","NP_001041640.1","disintegrin and metalloproteinase domain-containing protein 28 isoform 4 precursor","774","This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are typically membrane-anchored, although a form of this protein may be secreted. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a mature protein product. This protein may bind to integrins and regulate lymphocyte migration by enhancing cell adhesion. [provided by RefSeq, Aug 2015]. "
> "Q9D020-3","NP_001239303.1","cytosolic 5'-nucleotidase 3A isoform 2","297",""
11390d11365
< "Q8BMB3-1","NP_075803.2","eukaryotic translation initiation factor 4E type 2 isoform 3","234",""
11392d11366
< "Q91W59-1","NP_064692.2","RNA-binding motif, single-stranded-interacting protein 1 isoform 3","403",""
11396a11371
> "Q925Q8-1","NP_001136042.1","dachshund homolog 2 isoform 1","606",""
11400a11376
> "Q9CWK3-1","NP_001272834.1","CD2 antigen cytoplasmic tail-binding protein 2","342",""
11402,11403c11378
< "Q9JIL6-1","NP_444348.1","G-protein coupled receptor family C group 5 member D isoform 2","300",""
< "P25425-1","NP_945151.2","POU domain, class 2, transcription factor 1 isoform L","758",""
---
> "Q6PFQ7-1","NP_001034192.1","ras GTPase-activating protein 4 isoform 2","756",""
11407d11381
< "Q8BFQ3-1","NP_780702.1","ovarian cancer G-protein coupled receptor 1","365",""
11409,11410c11383,11385
< "Q8VIM5-1","NP_666498.2","myocardin isoform B","935",""
< "Q6KCD5-1","NP_957684.1","nipped-B-like protein isoform b","2691",""
---
> "P26883-1","NP_001289006.1","peptidyl-prolyl cis-trans isomerase FKBP1A isoform 1","108","This gene is a member of the immunophilin family. The encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, and is associated with immunoregulation, protein folding, receptor signaling, protein trafficking and T-cell activation. It may modulate the calcium release activity of the ryanodine receptor Ryr1. It also interacts with the type I TGF-beta receptor. Disruption of this gene in mouse causes severe ventricular defects. Pseudogenes of this gene have been defined on chromosomes 4, 10, 14, and 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. "
> "Q8K4J0-1","NP_001103684.1","protein artemis isoform 3","486","This gene encodes a member of the SNM1 family of nucleases and is involved in V(D)J recombination and DNA repair. This protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Homozygous knockout mice for this gene exhibit severe combined immunodeficiency with sensitivity to ionizing radiation. Mutations in this gene in humans can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]. "
> "Q8BH60-1","NP_001186201.1","Golgi-associated PDZ and coiled-coil motif-containing protein isoform a","463",""
11412c11387
< "Q9WV31-1","NP_061260.1","activity-regulated cytoskeleton-associated protein","396",""
---
> "Q91W59-1","NP_001135403.1","RNA-binding motif, single-stranded-interacting protein 1 isoform 2","401",""
11414d11388
< "P62889-1","NP_033109.1","60S ribosomal protein L30","115",""
11416c11390,11391
< "Q8BGU2-1","NP_766221.1","cerebellin-2 precursor","224","The protein encoded by this gene belongs to a family of secreted neuronal glycoproteins. The transcript is broadly expressed in the embryonic and adult brain with higher levels in some regions including the olfactory bulb, thalamus, and cerebral cortex. The protein can bind to presynaptic neurexins and induce synaptogenesis in cultured neurons. Null mutant mice are viable, fertile and do not display obvious neuroanatomical defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
---
> "P49586-1","NP_001156631.1","choline-phosphate cytidylyltransferase A","367",""
> "Q8CFC2-1","NP_001165086.1","myelin transcription factor 1 isoform 3","1169","This gene is a member of the myelin transcription factor 1 gene family. The encoded protein, a zinc finger DNA-binding protein, is involved in regulation of oligodendrocyte differentiation and proliferation in the developing central nervous system. The gene product has a role in remyelination through regeneration of oligodendrocyte lineage cells in response to demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]. "
11422a11398,11400
> "Q8K120-1","NP_001161818.1","nuclear factor of activated T-cells, cytoplasmic 4 isoform 2","890",""
> "Q07231-1","NP_001038168.1","zinc finger and SCAN domain-containing protein 21","555",""
> "Q8BFQ3-1","NP_001171144.1","ovarian cancer G-protein coupled receptor 1","365",""
11427,11428d11404
< "Q8R080-1","NP_038910.1","G2 and S phase-expressed protein 1","741",""
< "Q61772-1","NP_034271.3","ephrin type-A receptor 7 isoform 1 precursor","998",""
11431a11408
> "Q9DBU2-1","NP_001277618.1","N-alpha-acetyltransferase 60 isoform 2","177",""
11434a11412
> "Q3V188-1","NP_001162164.1","poly(U)-specific endoribonuclease isoform 2 precursor","412",""
11437a11416
> "Q61772-1","NP_001277363.1","ephrin type-A receptor 7 isoform 3 precursor","994",""
11440a11420,11421
> "Q6PHZ8-1","NP_001186171.1","Kv channel-interacting protein 4 isoform 1","250",""
> "P16305-1","NP_001093111.1","gamma-aminobutyric acid receptor subunit alpha-6 isoform 1 precursor","453",""
11442a11424
> "Q9QYI5-3","NP_001153355.1","dnaJ homolog subfamily B member 2 isoform 3","324",""
11445c11427
< "P50172-1","NP_032314.2","corticosteroid 11-beta-dehydrogenase isozyme 1","292",""
---
> "Q8VHW4-1","NP_001186230.1","voltage-dependent calcium channel gamma-5 subunit","275",""
11446a11429
> "P48794-1","NP_001073344.1","hyaluronidase PH-20 precursor","512",""
11448a11432
> "Q9Z351-1","NP_001006675.1","potassium voltage-gated channel subfamily KQT member 2 isoform 6","570",""
11451,11454c11435,11437
< "Q60722-1","NP_038713.1","transcription factor 4 isoform a","670",""
< "Q62406-1","NP_032389.2","interleukin-1 receptor-associated kinase 1 isoform 4","710",""
< "Q3UVR3-1","NP_542966.2","tau-tubulin kinase 2 isoform 1","1312",""
< "Q31125-1","NP_032228.2","zinc transporter SLC39A7 precursor","476",""
---
> "P50172-1","NP_001038216.1","corticosteroid 11-beta-dehydrogenase isozyme 1","292",""
> "A2BIM8-1","NP_001157998.1","major urinary protein 11 precursor","181",""
> "P21570-1","NP_001155203.1","angiogenin precursor","145","This gene encodes a member of the pancreatic ribonuclease A superfamily and is a potent inducer of neovascularization. The encoded protein is a secreted multifunctional tRNA-specific ribonuclease that promotes angiogenesis in response to angiogenetic stimuli such as hypoxia, mediates stress-induced translational repression by cleaving cellular tRNAs, stimulates cell proliferation by mediating rRNA transcription in prostate cancer cells, and is involved in neurite pathfinding. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the ribonuclease, RNase A family 4 gene. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. Multiple pseudogenes have been found for this gene. [provided by RefSeq, Jun 2009]. "
11457,11458c11440
< "Q61214-1","NP_031916.1","dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1","763",""
< "Q9DC04-3","NP_599018.3","regulator of G-protein signaling 3 isoform 2","966",""
---
> "Q31125-1","NP_001071177.1","zinc transporter SLC39A7 precursor","476",""
11459a11442
> "P70670-1","NP_038636.2","nascent polypeptide-associated complex subunit alpha isoform b","215",""
11463d11445
< "Q9D824-1","NP_077145.2","pre-mRNA 3'-end-processing factor FIP1 isoform 2","545",""
11468d11449
< "P97792-1","NP_034118.1","coxsackievirus and adenovirus receptor homolog isoform b precursor","352","This gene encodes a protein that is part of the Cortical Thymocyte marker in Xenopus (CTX) subfamily within the immunoglobulin superfamily. Members of this subfamily, predominantly expressed on the surface of endothelial and epithelial cells, help establish cell polarity and provide a barrier function, regulating migration of immune cells. This protein, first identified as the receptor for adenovirus subgroup C and coxsakieviruses group B, is developmentally regulated and plays an important role in cardiac development. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]. "
11470a11452
> "Q6IQX8-1","NP_001240623.1","zinc finger protein 219 isoform 1","726",""
11473d11454
< "Q9Z222-1","NP_058584.3","N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2","397",""
11474a11456
> "P06876-1","NP_001185843.1","transcriptional activator Myb isoform 1","755",""
11477d11458
< "Q8R3B1-1","NP_062650.1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 2","756",""
11478a11460
> "Q7TMK9-1","NP_001271257.1","heterogeneous nuclear ribonucleoprotein Q isoform 3","561",""
11480a11463
> "Q04736-1","NP_001192061.1","tyrosine-protein kinase Yes","541",""
11482c11465
< "Q04736-1","NP_033561.1","tyrosine-protein kinase Yes","541",""
---
> "Q99PP2-1","NP_067321.2","zinc finger protein 318 isoform 2","1154",""
11485c11468
< "P21570-1","NP_031473.1","angiogenin precursor","145","This gene encodes a member of the pancreatic ribonuclease A superfamily and is a potent inducer of neovascularization. The encoded protein is a secreted multifunctional tRNA-specific ribonuclease that promotes angiogenesis in response to angiogenetic stimuli such as hypoxia, mediates stress-induced translational repression by cleaving cellular tRNAs, stimulates cell proliferation by mediating rRNA transcription in prostate cancer cells, and is involved in neurite pathfinding. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the ribonuclease, RNase A family 4 gene. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. Multiple pseudogenes have been found for this gene. [provided by RefSeq, Jun 2009]. "
---
> "P63213-1","NP_001033726.1","guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor","71",""
11489,11490d11471
< "P97432-1","NP_032702.1","next to BRCA1 gene 1 protein isoform 1","988",""
< "Q6PFQ7-1","NP_598675.2","ras GTPase-activating protein 4 isoform 1","802",""
11492c11473,11474
< "Q9WVQ1-1","NP_056638.1","membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 2","1112",""
---
> "P97868-1","NP_035377.2","E3 ubiquitin-protein ligase RBBP6 isoform 1","1790",""
> "Q8BVF7-1","NP_666216.1","gamma-secretase subunit APH-1A isoform 1","247","This gene encodes a subunit of the gamma-secretase complex, which is localized to the endoplasmic reticulum and golgi apparatus. Gamma-secretase is a multi-protein enzyme that catalyzes intramembraneous proteolysis of type I transmembrane proteins and is essential for many signaling pathways, including the Notch signaling pathway. Studies suggest that the protein encoded by this locus binds directly to substrates of the gamma-secretase complex, including the beta-amyloid precursor protein which is associated with Alzheimer disease progression. This gene is required for normal embryonic development and survival, and disruption is associated with defects in the yolk sack angiogenesis, neural tube formation, and somitogenesis. A pseudogene of this gene is located on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
11494c11476
< "Q8K0W9-1","NP_758458.1","DPH3 homolog isoform 1","82",""
---
> "Q99K01-1","NP_001034622.1","pyridoxal-dependent decarboxylase domain-containing protein 1 isoform 3","710",""
11496d11477
< "Q923J1-1","NP_067425.2","transient receptor potential cation channel subfamily M member 7 isoform 1","1863",""
11497a11479
> "Q9QYN3-1","NP_001170844.1","kallikrein-11 isoform 1 preproprotein","276","This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]. "
11501c11483
< "Q811Q9-1","NP_997593.1","choline-phosphate cytidylyltransferase B isoform 1","369",""
---
> "P70460-1","NP_001268950.1","vasodilator-stimulated phosphoprotein isoform 2","374",""
11503a11486
> "Q923J1-1","NP_001157797.1","transient receptor potential cation channel subfamily M member 7 isoform 2","1862",""
11505a11489
> "P18572-1","NP_001070652.1","basigin isoform 2 precursor","273",""
11507,11508c11491,11492
< "P46656-1","NP_032022.1","adrenodoxin, mitochondrial isoform 1 precursor","188","Ferrodoxins are iron-sulfur proteins that facilitate monooxygenase reactions catalyzed by P450 enzymes. The protein encoded by this gene is present in the mitochondrial matrix and transfers electrons from ferredoxin reductase to steroidogenic mitochondrial cytochrome P450 proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]. "
< "Q922Z0-1","NP_081718.2","D-aspartate oxidase isoform 1 precursor","341",""
---
> "P97379-1","NP_001074263.1","ras GTPase-activating protein-binding protein 2 isoform a","482",""
> "P70280-1","NP_001289067.1","vesicle-associated membrane protein 7 isoform 2","181",""
11512c11496
< "Q6P1G2-1","NP_038938.1","lysine-specific demethylase 2B isoform 2","776","The protein encoded by this gene is a H3K36-specific histone demethylase, which contains an N-terminal jumonji C domain, a CxxC zinc finger domain, a plant homeodomain finger, an F-box, and eight leucine-rich repeats. Amongst its demonstrated functions, this protein plays roles in the suppression of premature cellular senescence, leukemia maintenance and development, maintenance of mouse embryonic stem cell pluripotency, and induced pluripotent stem cell generation. Mice homozygous for a targeted deletion of the zinc finger domain display embryonic lethality with development ceasing at approximately 7 to 8 days post coitum, demonstrating an essential role in early development. A pseudogene of this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
---
> "Q8K0W9-1","NP_001040898.1","DPH3 homolog isoform 2","57",""
11514d11497
< "Q9WVP1-1","NP_033808.2","AP-1 complex subunit mu-2 isoform 2","423",""
11515a11499
> "Q9WVQ1-1","NP_001164216.1","membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 3","1098",""
11519,11520d11502
< "Q9DBN5-1","NP_080103.1","lon protease homolog 2, peroxisomal isoform 1","852",""
< "P70670-1","NP_001106670.1","nascent polypeptide-associated complex subunit alpha isoform a","2187",""
11522a11505
> "P13634-1","NP_001077426.1","carbonic anhydrase 1","261",""
11524a11508
> "Q9Z0F4-1","NP_001278204.1","calcium and integrin-binding protein 1 isoform 2","186",""
11527,11528c11511
< "Q9Z0L2-1","NP_033841.1","artemin isoform 1 preproprotein","224","This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Mice lacking a functional copy of this gene exhibit ptosis and impaired development of the sympathetic nervous system. [provided by RefSeq, Aug 2016]. "
< "P11416-1","NP_033050.2","retinoic acid receptor alpha isoform 1","462",""
---
> "Q3UJB9-1","NP_001288029.1","enhancer of mRNA-decapping protein 4 isoform 1","1406","The protein encoded by this gene is thought to promote mRNA decay, and is known to interact with several mRNA decapping proteins. In humans, decreased expression of this gene prevents the accumulation of mRNA decapping proteins to mRNA processing bodies (P-body). Alternative splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]. "
11534d11516
< "P23798-1","NP_033571.1","polycomb group RING finger protein 2","342",""
11544,11545c11526
< "Q02357-1","NP_112435.2","ankyrin-1 isoform 2","1848",""
< "Q8R2X8-1","NP_079781.2","golgin-45 isoform a","410",""
---
> "P97411-1","NP_001239195.1","islet cell autoantigen 1 isoform 2","457",""
11550d11530
< "P54265-1","NP_115794.1","myotonin-protein kinase isoform 1","631","The protein encoded by this gene is a serine/threonine protein kinase that contains coiled-coil and C-terminal membrane association domains. In the embryonic mouse, it is found in cardiac and skeletal myocytes where it appears to play a role in myogenesis. In adults, the transcript is localized to several tissues including brain, heart, and skeletal and smooth muscle, and a function in cytoskeletal remodeling has been described. Transcripts with expanded CUG repeats in the 3' untranslated region mediate alternative splicing of several genes and sequester RNA binding proteins and RNA transcripts that contain CAG repeats, resulting in myotonic dystrophy, an autosomal dominant neuromuscular disorder. Alternative splicing results in multiple protein coding and non-coding transcript variants. [provided by RefSeq, Oct 2014]. "
11552c11532
< "Q9D777-1","NP_076006.2","tumor necrosis factor ligand superfamily member 13 isoform 1","241",""
---
> "Q91Y44-1","NP_001073342.1","bromodomain testis-specific protein isoform B","326","The protein encoded by this gene belongs to the BET protein family. BET proteins have two N-terminal bromodomains and one C-terminal extraterminal domain (ET domain). BET proteins regulate chromatin reorganization via binding to acetylated histones. This gene is thought to play a role in the transcriptional regulation of spermatogenesis. Although referred to as testis-specific bromodomain (Brdt) protein, RT-PCR indicates that this gene is expressed in both mouse oocytes and testes. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]. "
11554d11533
< "Q925T6-1","NP_597699.1","glutamate receptor-interacting protein 1 isoform 3","1034","This gene encodes a protein containing multiple PDZ (post synaptic density protein, Drosophila disc large tumor suppressor, and zonula occludens-1 protein) domains. The encoded protein acts as a mediator between cytoskeletal and membrane proteins, particularly in neuronal cells, and facilitates complex formation at the cell membrane. Mutation of this gene can cause embryonic lethality resulting from defects of the dermo-epidermal junction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. "
11556a11536
> "P97432-1","NP_001239149.1","next to BRCA1 gene 1 protein isoform 1","988",""
11559,11560c11539
< "P03958-1","NP_031424.1","adenosine deaminase","352",""
< "Q61644-1","NP_848142.1","protein kinase C and casein kinase substrate in neurons protein 1","441",""
---
> "P35802-1","NP_001240683.1","neuronal membrane glycoprotein M6-a isoform 2","267",""
11567d11545
< "Q91V12-1","NP_579926.2","cytosolic acyl coenzyme A thioester hydrolase isoform 2","379",""
11569d11546
< "P05214-1","NP_033475.1","tubulin alpha-3 chain","450",""
11574d11550
< "Q8K120-1","NP_076188.3","nuclear factor of activated T-cells, cytoplasmic 4 isoform 1","901",""
11577d11552
< "Q8VHW4-1","NP_542375.1","voltage-dependent calcium channel gamma-5 subunit","275",""
11583d11557
< "Q9EPX5-1","NP_038939.2","F-box/LRR-repeat protein 12 isoform a","326",""
11589a11564
> "P21126-1","NP_001265200.1","ubiquitin-like protein 4A","157","This locus represents naturally occurring readthrough transcription between the neighboring Slc10a3 (solute carrier family 10 (sodium/bile acid cotransporter family), member 3) and Ubl4 (ubiquitin-like 4) genes on chromosome X. While some readthrough transcripts encode a protein that is identical to the downstream gene product, at least one readthrough transcript appears to be a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, May 2013]. "
11591a11567
> "Q6P1G2-1","NP_001003953.1","lysine-specific demethylase 2B isoform 1","1309","The protein encoded by this gene is a H3K36-specific histone demethylase, which contains an N-terminal jumonji C domain, a CxxC zinc finger domain, a plant homeodomain finger, an F-box, and eight leucine-rich repeats. Amongst its demonstrated functions, this protein plays roles in the suppression of premature cellular senescence, leukemia maintenance and development, maintenance of mouse embryonic stem cell pluripotency, and induced pluripotent stem cell generation. Mice homozygous for a targeted deletion of the zinc finger domain display embryonic lethality with development ceasing at approximately 7 to 8 days post coitum, demonstrating an essential role in early development. A pseudogene of this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
11592a11569,11570
> "Q7TSC1-1","NP_001185973.1","protein PRRC2A isoform 2","2157",""
> "Q0P678-1","NP_001025164.1","zinc finger CCCH domain-containing protein 18 isoform a","972",""
11593a11572
> "Q64012-1","NP_001132983.1","RNA-binding protein Raly short isoform","296",""
11595d11573
< "Q9D7M1-1","NP_083883.1","glucose-induced degradation protein 8 homolog","228",""
11596a11575
> "P62889-1","NP_001156957.1","60S ribosomal protein L30","115",""
11599d11577
< "Q925Q8-1","NP_291083.1","dachshund homolog 2 isoform 2","634",""
11602d11579
< "Q08048-1","NP_034557.3","hepatocyte growth factor isoform 1 preproprotein","728","This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the hepatocyte growth factor alpha and beta chains, which heterodimerize to form the mature active protein. Although this protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Homozygous knockout mice for this gene exhibit embryonic lethality due to impaired development of the placenta and liver. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. "
11606,11607d11582
< "Q811D0-1","NP_031888.2","disks large homolog 1 isoform 1","927",""
< "O09046-1","NP_034345.2","L-amino-acid oxidase precursor","630",""
11608a11584,11585
> "Q5SSM3-1","NP_001092758.1","rho GTPase-activating protein 44 isoform 1","808",""
> "P21129-1","NP_001243033.1","P3 protein","473",""
11610c11587
< "P21126-1","NP_663380.1","ubiquitin-like protein 4A","157",""
---
> "Q9D8V0-1","NP_001153023.1","minor histocompatibility antigen H13 isoform 1","394",""
11614a11592
> "O89116-1","NP_001280615.1","vesicle transport through interaction with t-SNAREs homolog 1A isoform 3","187",""
11617d11594
< "Q91WG8-1","NP_056643.3","bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 2","753",""
11620d11596
< "Q9WTJ6-1","NP_001273487.1","tesmin isoform c","295",""
11624d11599
< "P20934-1","NP_034291.1","protein EVI2A precursor","223",""
11627a11603
> "Q8BMB3-1","NP_001034259.1","eukaryotic translation initiation factor 4E type 2 isoform 1","245",""
11630c11606,11609
< "Q64012-1","NP_075619.2","RNA-binding protein Raly short isoform","296",""
---
> "Q9JI57-1","NP_001074931.1","general transcription factor II-I repeat domain-containing protein 1 isoform b","1104",""
> "P55098-1","NP_001156773.1","peroxisome biogenesis factor 2","305",""
> "Q9JHH2-1","NP_001121552.1","tetraspanin-32 isoform a","256",""
> "Q3UHC7-1","NP_001001602.2","disabled homolog 2-interacting protein isoform 3","1124",""
11633c11612
< "P98084-1","NP_031487.1","amyloid-beta A4 precursor protein-binding family A member 2","750",""
---
> "Q9D824-1","NP_001153045.1","pre-mRNA 3'-end-processing factor FIP1 isoform 1","581",""
11635,11636c11614
< "P26883-1","NP_032045.1","peptidyl-prolyl cis-trans isomerase FKBP1A isoform 1","108","This gene is a member of the immunophilin family. The encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, and is associated with immunoregulation, protein folding, receptor signaling, protein trafficking and T-cell activation. It may modulate the calcium release activity of the ryanodine receptor Ryr1. It also interacts with the type I TGF-beta receptor. Disruption of this gene in mouse causes severe ventricular defects. Pseudogenes of this gene have been defined on chromosomes 4, 10, 14, and 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. "
< "Q61464-1","NP_032743.2","zinc finger protein 638 isoform 1","1926",""
---
> "Q8BIF0-1","NP_001186278.1","CD99 antigen-like protein 2 isoform 1 precursor","237",""
11640d11617
< "P47739-1","NP_031462.2","aldehyde dehydrogenase, dimeric NADP-preferring isoform 1","453",""
11643,11644c11620,11621
< "P97465-1","NP_034200.4","docking protein 1 isoform 1","482",""
< "Q08639-1","NP_033387.1","transcription factor Dp-1 isoform a","410",""
---
> "Q925F4-1","NP_001242922.1","RING finger protein 37","539",""
> "Q9Z222-1","NP_001162585.1","N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2","397",""
11645a11623,11624
> "Q6PAV2-1","NP_080377.2","probable E3 ubiquitin-protein ligase HERC4 isoform 2","1049",""
> "Q5RKZ7-1","NP_064426.2","molybdenum cofactor biosynthesis protein 1 isoform 1","636",""
11648a11628,11629
> "Q8VEM1-1","NP_001277678.1","E3 ubiquitin-protein ligase RNF130 isoform 2 precursor","384",""
> "Q99N48-1","NP_113572.1","synaptotagmin-like protein 3 isoform a","607",""
11650c11631
< "Q8R3Z5-1","NP_112450.1","voltage-dependent L-type calcium channel subunit beta-1 isoform A","524",""
---
> "P62509-1","NP_001230721.1","estrogen-related receptor gamma isoform 2","435",""
11652c11633
< "Q8BGF7-1","NP_598753.1","PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 1","1200",""
---
> "Q61644-1","NP_001273672.1","protein kinase C and casein kinase substrate in neurons protein 1","441",""
11660c11641
< "Q8C6P8-1","NP_001161974.1","zinc finger protein 57 isoform 2","418",""
---
> "Q6KCD5-1","NP_081983.2","nipped-B-like protein isoform a","2798",""
11667c11648
< "Q7SIG6-1","NP_001128664.1","arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform c","1000",""
---
> "Q02053-1","NP_001129557.1","ubiquitin-like modifier-activating enzyme 1 isoform 2","1058","This gene encodes a member of the ubiquitin-activating E1 family. The encoded protein initiates the ubiquitin activation and transfer cascade, catalyzing the first step in ubiquitin conjugation to mark cellular proteins for proteasome degradation. Ubiquitin activating enzymes use ATP to form a thioester between a conserved catalytic cysteine of the enzyme and the C-terminal carboxylate of ubiquitin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
11671d11651
< "O35484-1","NP_061215.1","antizyme inhibitor 1 isoform 1","448","The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]. "
11673,11676d11652
< "Q9DCT8-1","NP_077185.1","cysteine-rich protein 2 isoform 1","208",""
< "P28659-1","NP_941955.1","CUGBP Elav-like family member 1 isoform 2","486",""
< "Q925F4-1","NP_542129.2","RING finger protein 37","539",""
< "Q921C3-1","NP_660107.2","bromodomain and WD repeat-containing protein 1 isoform A","2304",""
11679c11655
< "P46096-1","NP_033332.1","synaptotagmin-1 isoform 1","421",""
---
> "Q9D777-1","NP_001152977.1","tumor necrosis factor ligand superfamily member 13 isoform 2","240",""
11680a11657
> "O35681-1","NP_001107588.1","synaptotagmin-3","587",""
11682c11659
< "P98203-1","NP_258435.2","armadillo repeat protein deleted in velo-cardio-facial syndrome homolog isoform 1","962",""
---
> "B1AVD1-1","NP_001276658.1","xaa-Pro aminopeptidase 2 isoform 2 precursor","741",""
11683a11661,11662
> "Q8K410-1","NP_001280622.1","disintegrin and metalloproteinase domain-containing protein 32 isoform 2 precursor","677","This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene was found to be expressed predominantly in the pachytene spermatocytes, where the processed protein is localized to the sperm surface. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]. "
> "P12388-1","NP_001167641.1","plasminogen activator inhibitor 2, macrophage","415",""
11686a11666
> "Q69ZA1-1","NP_001074527.1","cyclin-dependent kinase 13 isoform 1","1511",""
11688d11667
< "Q9JI57-1","NP_065064.2","general transcription factor II-I repeat domain-containing protein 1 isoform a","1072",""
11693d11671
< "Q8VEM1-1","NP_067515.2","E3 ubiquitin-protein ligase RNF130 isoform 1 precursor","419",""
11694a11673
> "Q9D7M1-1","NP_001276580.1","glucose-induced degradation protein 8 homolog","228",""
11697d11675
< "Q61730-1","NP_598864.1","interleukin-1 receptor accessory protein isoform b precursor","360",""
11701,11702d11678
< "P13634-1","NP_033929.2","carbonic anhydrase 1","261",""
< "P70182-1","NP_032873.2","phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 2","546",""
11704d11679
< "Q8BW72-1","NP_759014.2","lysine-specific demethylase 4A isoform 2","1033",""
11712d11686
< "Q8BGW8-1","NP_722481.1","transcription cofactor vestigial-like protein 2 isoform 1","322","This gene is a member of the Vestigial-like (Vgl) gene family and is upregulated during muscle differentiation. The product of this gene interacts with and modifies the DNA-binding properties of the transcription factor, TEF-1, and is important for muscle tissue development. Reduced expression of this gene leads to a reduction in the terminal differentiation of muscle cells. Alternate splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]. "
11714a11689,11690
> "Q9WV31-1","NP_001263613.1","activity-regulated cytoskeleton-associated protein","396",""
> "Q8BGW8-1","NP_001287886.1","transcription cofactor vestigial-like protein 2 isoform 2","321","This gene is a member of the Vestigial-like (Vgl) gene family and is upregulated during muscle differentiation. The product of this gene interacts with and modifies the DNA-binding properties of the transcription factor, TEF-1, and is important for muscle tissue development. Reduced expression of this gene leads to a reduction in the terminal differentiation of muscle cells. Alternate splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]. "
11716d11691
< "Q9Z1B3-1","NP_062651.2","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 2","1173",""
11717a11693
> "Q9EST3-1","NP_001160019.1","eukaryotic translation initiation factor 4E transporter isoform a","983",""
11720d11695
< "Q9Z0F4-1","NP_036000.1","calcium and integrin-binding protein 1 isoform 1","191",""
11725c11700
< "Q9EPW0-1","NP_766559.2","inositol polyphosphate-4-phosphatase type I A isoform 2","690",""
---
> "Q6Q6R3-1","NP_444480.1","cysteine-rich protein 3 isoform TLP-B","205",""
11727c11702,11703
< "P0DPD9-1","NP_808810.1","Eef1akmt4-Ece2 readthrough isoform a","910","This locus represents naturally occurring readthrough transcription between the adjacent genes eukaryotic translation elongation factor 1 alpha lysine specific methyltransferase 4 (GeneID:110599566) and endothelin converting enzyme 2 (GeneID:107522). The readthrough transcript representing this gene encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jul 2017]. "
---
> "Q60755-1","NP_001036190.1","calcitonin receptor isoform 1a precursor","496",""
> "Q3UPW2-1","NP_001156603.1","ETS-related transcription factor Elf-3 isoform 1","391",""
11729d11704
< "Q9JLJ4-1","NP_062296.1","elongation of very long chain fatty acids protein 2 isoform 1","292",""
11731,11732c11706,11708
< "P70280-1","NP_035645.1","vesicle-associated membrane protein 7 isoform 1","220",""
< "Q9DCB4-1","NP_150289.1","cAMP-regulated phosphoprotein 21 isoform 2","807",""
---
> "O88879-1","NP_001036023.1","apoptotic protease-activating factor 1 isoform 1","1249",""
> "Q9JHC9-1","NP_001277988.1","ETS-related transcription factor Elf-2 isoform 2","581",""
> "Q80TM6-1","NP_001161764.1","R3H domain-containing protein 2 isoform 1","1044",""
11734d11709
< "P97379-1","NP_035946.2","ras GTPase-activating protein-binding protein 2 isoform a","482",""
11738a11714
> "O08901-1","NP_001106650.1","mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 1","1059",""
11739a11716,11717
> "Q8BK26-1","NP_001155323.1","F-box only protein 44 isoform 1","255",""
> "Q925F3-1","NP_001075446.1","E3 ubiquitin-protein ligase RNF144A","292",""
11741,11742c11719,11721
< "P0C027-1","NP_067406.2","diphosphoinositol polyphosphate phosphohydrolase 3-beta","164",""
< "Q80WQ6-1","NP_766160.2","inactive rhomboid protein 2","827",""
---
> "Q9DBU5-1","NP_001243014.1","E3 ubiquitin-protein ligase RNF6 isoform 1","667",""
> "Q5HZI1-1","NP_001005863.1","microtubule-associated tumor suppressor 1 homolog isoform 1","1210",""
> "Q8K2P7-1","NP_001159928.1","sodium-coupled neutral amino acid transporter 1","485",""
11744d11722
< "O35681-1","NP_057872.3","synaptotagmin-3","587",""
11746,11748d11723
< "O89116-1","NP_058558.1","vesicle transport through interaction with t-SNAREs homolog 1A isoform 2","217",""
< "Q61818-1","NP_033047.2","retinoic acid-induced protein 1","1889",""
< "Q3UHH1-1","NP_082272.1","zinc finger SWIM domain-containing protein 8 isoform 1","1832",""
11749a11725
> "Q91X88-1","NP_001277587.1","protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 isoform 3","638",""
11751,11752d11726
< "P06876-1","NP_034978.3","transcriptional activator Myb isoform 2","636",""
< "Q9JHC9-1","NP_075991.1","ETS-related transcription factor Elf-2 isoform 1","593",""
11754,11755d11727
< "Q60953-1","NP_835188.2","protein PML isoform 2","885",""
< "P82343-1","NP_075621.3","N-acylglucosamine 2-epimerase isoform 1","430",""
11757c11729
< "Q9CR50-1","NP_080833.1","RING finger and CHY zinc finger domain-containing protein 1 isoform 1","261","This gene encodes a protein containing CHY-, CTCHY-, and RING-type zinc-fingers. The encoded protein functions as an E3 ubiquitin ligase, and mediates the degradation of target proteins such as p53. The activity of this protein is important in cell cycle regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]. "
---
> "P00688-1","NP_001036176.1","pancreatic alpha-amylase precursor","508",""
11758a11731
> "P46096-1","NP_001239270.1","synaptotagmin-1 isoform 1","421",""
11761c11734
< "P18572-1","NP_033898.1","basigin isoform 1 precursor","389",""
---
> "P53811-1","NP_001288573.1","phosphatidylinositol transfer protein beta isoform isoform 3","198","This gene encodes a member of the phosphatidylinositol transfer protein family. The encoded protein catalyzes the transfer of phospholipids (phosphatidylinositol and phosphatidylcholine) between membranes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. "
11763d11735
< "Q9D067-1","NP_683724.2","nuclear protein MDM1 isoform 2","708",""
11766a11739
> "Q8BNV1-1","NP_001074468.1","tRNA (uracil-5-)-methyltransferase homolog A isoform 2","613",""
11771a11745
> "Q62219-1","NP_001276479.1","transforming growth factor beta-1-induced transcript 1 protein isoform a","461",""
11772a11747
> "O54962-1","NP_001033320.1","barrier-to-autointegration factor","89",""
11776,11778c11751,11752
< "Q3UIA2-1","NP_653112.2","rho GTPase-activating protein 17 isoform a","846",""
< "Q7TMK9-1","NP_062770.1","heterogeneous nuclear ribonucleoprotein Q isoform 2","562",""
< "Q3U6Q4-1","NP_001075035.1","phosphoinositide 3-kinase regulatory subunit 6 isoform 1","756","Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 11. The protein binds to both the catalytic subunit and to G beta-gamma, and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
---
> "Q9EPW0-1","NP_001277726.1","inositol polyphosphate-4-phosphatase type I A isoform 3","977",""
> "P15702-1","NP_001032899.1","leukosialin precursor","395",""
11780d11753
< "Q8K410-1","NP_700446.2","disintegrin and metalloproteinase domain-containing protein 32 isoform 1 preproprotein","754","This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene was found to be expressed predominantly in the pachytene spermatocytes, where the processed protein is localized to the sperm surface. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]. "
11783c11756,11757
< "Q6Q6R3-1","NP_858050.1","cysteine-rich protein 3 isoform TLP-A","204",""
---
> "Q9CZ62-1","NP_001152836.1","centrosomal protein of 97 kDa isoform 2","157",""
> "Q9JIL6-1","NP_001192325.1","G-protein coupled receptor family C group 5 member D isoform 1","344",""
11788d11761
< "Q5XPI3-1","NP_115932.1","E3 ubiquitin-protein ligase RNF123 isoform 2","1314",""
11792d11764
< "Q5SSM3-1","NP_778168.2","rho GTPase-activating protein 44 isoform 2","764",""
11799d11770
< "P83940-1","NP_080732.1","elongin-C isoform 2","112",""
11801c11772
< "Q6WKZ8-1","NP_666190.2","E3 ubiquitin-protein ligase UBR2 isoform 1","1755",""
---
> "B2RXV4-1","NP_001074728.1","feline leukemia virus subgroup C receptor-related protein 1 isoform 1","560",""
11803,11804c11774
< "Q64326-1","NP_032586.1","adrenocorticotropic hormone receptor","296",""
< "Q9EQH7-1","NP_112463.2","bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform 1","873",""
---
> "Q03146-1","NP_001185760.1","epithelial discoidin domain-containing receptor 1 isoform 1 precursor","911",""
11806d11775
< "Q65Z40-1","NP_001288259.1","wings apart-like protein homolog isoform 2","1194","Studies suggest that the protein encoded by this gene is important for the release of cohesin from chromatin. This gene product is thought to be essential for development, and reduced expression of this gene in cells causes defects in chromatin structure. High levels of expression of the human ortholog of this gene are observed in cervical cancers, and expression of the human ortholog of this gene in mice results in tumor formation. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Aug 2014]. "
11809c11778
< "Q9EST3-1","NP_076232.2","eukaryotic translation initiation factor 4E transporter isoform a","983",""
---
> "Q8VHI4-1","NP_001272402.1","calcium-responsive transcription factor isoform 3","654",""
11811,11813c11780,11782
< "P49586-1","NP_034111.1","choline-phosphate cytidylyltransferase A","367",""
< "Q9D304-1","NP_075759.3","E3 ubiquitin-protein ligase RNF128 isoform 1 precursor","428",""
< "Q8CFC2-1","NP_032691.2","myelin transcription factor 1 isoform 1","1127","This gene is a member of the myelin transcription factor 1 gene family. The encoded protein, a zinc finger DNA-binding protein, is involved in regulation of oligodendrocyte differentiation and proliferation in the developing central nervous system. The gene product has a role in remyelination through regeneration of oligodendrocyte lineage cells in response to demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]. "
---
> "P70182-1","NP_001280636.1","phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 1","547",""
> "P17426-1","NP_001070732.1","AP-2 complex subunit alpha-1 isoform b","955",""
> "Q6GYP7-1","NP_001003719.1","ral GTPase-activating protein subunit alpha-1 isoform 3","2083",""
11816d11784
< "Q60755-1","NP_031614.2","calcitonin receptor isoform 1b precursor","533",""
11819c11787
< "P70460-1","NP_033525.2","vasodilator-stimulated phosphoprotein isoform 1","375",""
---
> "P20934-1","NP_001028883.1","protein EVI2A precursor","223",""
11821d11788
< "Q9JLB0-1","NP_064323.2","MAGUK p55 subfamily member 6 isoform b","539",""
11824a11792,11793
> "Q3UIA2-1","NP_001116112.1","rho GTPase-activating protein 17 isoform b","818",""
> "Q3UVR3-1","NP_001020027.1","tau-tubulin kinase 2 isoform 2","1243",""
11826a11796,11798
> "Q811Q9-1","NP_808214.1","choline-phosphate cytidylyltransferase B isoform 2","339",""
> "Q99LI8-1","NP_001152800.1","hepatocyte growth factor-regulated tyrosine kinase substrate isoform 1","776",""
> "Q02357-1","NP_001104253.1","ankyrin-1 isoform 1","1907",""
11829d11800
< "Q9JHG7-1","NP_064668.2","phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform","1102",""
11830a11802,11804
> "P83882-1","NP_063918.1","60S ribosomal protein L36a","106",""
> "Q8R2X8-1","NP_001153680.1","golgin-45 isoform b","403",""
> "Q9DCB4-1","NP_001171086.1","cAMP-regulated phosphoprotein 21 isoform 1","88",""
11833,11834d11806
< "P70451-1","NP_032026.2","tyrosine-protein kinase Fer isoform b","453",""
< "Q8K3P1-1","NP_700449.2","P2X purinoceptor 2 isoform a","485",""
11835a11808
> "Q9ERD6-1","NP_001153437.1","ras-specific guanine nucleotide-releasing factor RalGPS2 isoform a","590",""
11837,11838c11810
< "Q8CDA1-1","NP_848756.2","phosphatidylinositide phosphatase SAC2 isoform 1","1132",""
< "Q80U58-1","NP_109648.2","pumilio homolog 2 isoform 1","1066",""
---
> "P97465-1","NP_001278728.1","docking protein 1 isoform 2","419",""
11844,11845d11815
< "Q8VHI4-1","NP_631889.1","calcium-responsive transcription factor isoform 1","689",""
< "Q03526-1","NP_034713.2","tyrosine-protein kinase ITK/TSK isoform 2","619",""
11847c11817
< "Q3UPW2-1","NP_031947.1","ETS-related transcription factor Elf-3 isoform 2","371",""
---
> "Q8BVP5-1","NP_001153063.1","casein kinase I isoform gamma-2 isoform 2","415",""
11849,11851c11819
< "Q9EQF5-1","NP_073559.3","dihydropyrimidinase","519",""
< "P12388-1","NP_035241.1","plasminogen activator inhibitor 2, macrophage","415",""
< "P15702-1","NP_033285.1","leukosialin precursor","395",""
---
> "Q8R080-1","NP_001162143.1","G2 and S phase-expressed protein 1","741",""
11853d11820
< "Q60654-1","NP_055009.5","killer cell lectin-like receptor 7 isoform 2","267",""
11855a11823
> "Q7SIG6-1","NP_001004364.2","arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform b","955",""
11857a11826,11827
> "Q9D0E1-1","NP_001103383.1","heterogeneous nuclear ribonucleoprotein M isoform b","690",""
> "Q8BZ03-1","NP_001239387.1","serine/threonine-protein kinase D2","875",""
11862c11832
< "Q64092-1","NP_766060.2","transcription factor E3 isoform a","572",""
---
> "Q8C6P8-1","NP_001013767.1","zinc finger protein 57 isoform 1","421",""
11865,11866c11835
< "Q9QYN3-1","NP_064358.1","kallikrein-11 isoform 2 precursor","249","This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]. "
< "Q6PHZ8-1","NP_084541.3","Kv channel-interacting protein 4 isoform 4","229",""
---
> "Q3U6Q4-1","NP_001004435.1","phosphoinositide 3-kinase regulatory subunit 6 isoform 2","752","Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 11. The protein binds to both the catalytic subunit and to G beta-gamma, and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
11870d11838
< "O08901-1","NP_033902.2","mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 2","1058",""
11871a11840
> "Q8BKX1-1","NP_001032843.1","brain-specific angiogenesis inhibitor 1-associated protein 2 isoform c","482",""
11874c11843
< "Q8C5Q4-1","NP_848815.2","G-rich sequence factor 1 isoform 1","479",""
---
> "P47739-1","NP_001106196.1","aldehyde dehydrogenase, dimeric NADP-preferring isoform 1","453",""
11876,11877d11844
< "Q9D8V0-1","NP_034506.1","minor histocompatibility antigen H13 isoform 2","378",""
< "Q61532-1","NP_081694.1","mitogen-activated protein kinase 6","720",""
11880,11883d11846
< "Q80XQ2-1","NP_082438.3","TBC1 domain family member 5 isoform b","815",""
< "Q925F3-1","NP_542130.1","E3 ubiquitin-protein ligase RNF144A","292",""
< "Q8VBT9-1","NP_937866.1","tether containing UBX domain for GLUT4 isoform 2","473",""
< "Q99N48-1","NP_899226.2","synaptotagmin-like protein 3 isoform 3SIII","412",""
11889a11853
> "Q9Z1B3-1","NP_001139302.1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 1","1216",""
11891,11892c11855
< "Q07231-1","NP_035887.2","zinc finger and SCAN domain-containing protein 21","555",""
< "Q8BVF7-1","NP_666246.1","gamma-secretase subunit APH-1A isoform 2","265","This gene encodes a subunit of the gamma-secretase complex, which is localized to the endoplasmic reticulum and golgi apparatus. Gamma-secretase is a multi-protein enzyme that catalyzes intramembraneous proteolysis of type I transmembrane proteins and is essential for many signaling pathways, including the Notch signaling pathway. Studies suggest that the protein encoded by this locus binds directly to substrates of the gamma-secretase complex, including the beta-amyloid precursor protein which is associated with Alzheimer disease progression. This gene is required for normal embryonic development and survival, and disruption is associated with defects in the yolk sack angiogenesis, neural tube formation, and somitogenesis. A pseudogene of this gene is located on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
---
> "Q5BL07-1","NP_001280735.1","peroxisome biogenesis factor 1 isoform 1","1284",""
11899,11901c11862,11863
< "Q9JHH2-1","NP_064682.1","tetraspanin-32 isoform b","229",""
< "Q02053-1","NP_033483.2","ubiquitin-like modifier-activating enzyme 1 isoform 1","1118","This gene encodes a member of the ubiquitin-activating E1 family. The encoded protein initiates the ubiquitin activation and transfer cascade, catalyzing the first step in ubiquitin conjugation to mark cellular proteins for proteasome degradation. Ubiquitin activating enzymes use ATP to form a thioester between a conserved catalytic cysteine of the enzyme and the C-terminal carboxylate of ubiquitin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
< "Q99MD6-1","NP_694802.2","thioredoxin reductase 3 isoform 2","615","The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes the third TrxR, which unlike the other two isozymes, contains an additional N-terminal glutaredoxin (Grx) domain, and shows highest expression in testis. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is evidence for additional isoforms resulting from the use of a non-AUG (CUG), and an in-frame downstream AUG as translation initiation codons (PMID:20018845). [provided by RefSeq, Aug 2017]. "
---
> "P02762-1","NP_001128599.1","major urinary protein 11 precursor","180",""
> "Q8C5Q4-1","NP_001091946.1","G-rich sequence factor 1 isoform 2","362",""
11904a11867
> "Q8VIM5-1","NP_660118.3","myocardin isoform A","983",""
11905a11869
> "Q99MD6-1","NP_001171529.1","thioredoxin reductase 3 isoform 1","652","The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes the third TrxR, which unlike the other two isozymes, contains an additional N-terminal glutaredoxin (Grx) domain, and shows highest expression in testis. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is evidence for additional isoforms resulting from the use of a non-AUG (CUG), and an in-frame downstream AUG as translation initiation codons (PMID:20018845). [provided by RefSeq, Aug 2017]. "
11909a11874
> "Q08048-1","NP_001276387.1","hepatocyte growth factor isoform 1 preproprotein","728","This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the hepatocyte growth factor alpha and beta chains, which heterodimerize to form the mature active protein. Although this protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Homozygous knockout mice for this gene exhibit embryonic lethality due to impaired development of the placenta and liver. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. "
11912a11878
> "P40237-1","NP_001129527.1","CD82 antigen","266",""
11913a11880
> "Q9CR50-1","NP_001258726.1","RING finger and CHY zinc finger domain-containing protein 1 isoform 2","221","This gene encodes a protein containing CHY-, CTCHY-, and RING-type zinc-fingers. The encoded protein functions as an E3 ubiquitin ligase, and mediates the degradation of target proteins such as p53. The activity of this protein is important in cell cycle regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]. "
11917c11884
< "Q9ERD6-1","NP_076373.3","ras-specific guanine nucleotide-releasing factor RalGPS2 isoform a","590",""
---
> "O35347-1","NP_001276742.1","protein DGCR6 isoform 1","201","This gene encodes a protein that is similar to the gonadal protein in Drosophila (fruit fly). The encoded protein is thought to play a role in migration of neural crest cells during development. Deletions in the human gene are associated with DiGeorge syndrome (or velocardiofacial syndrome) which has many clinical features including cardiac abnormalities, cleft palate, atypical facial features, hypocalcemia, hypoparathyroidism and defective development or congenital absence of the thymus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. "
11920a11888
> "Q64326-1","NP_001258645.1","adrenocorticotropic hormone receptor","296",""
11924a11893,11895
> "Q8R3Z5-1","NP_001152791.1","voltage-dependent L-type calcium channel subunit beta-1 isoform C","479",""
> "P48542-1","NP_001020756.1","G protein-activated inward rectifier potassium channel 2 isoform Girk2B","327",""
> "P23798-1","NP_001156779.1","polycomb group RING finger protein 2","342",""
11927c11898
< "Q8K2P7-1","NP_598847.2","sodium-coupled neutral amino acid transporter 1","485",""
---
> "Q61730-1","NP_001152790.1","interleukin-1 receptor accessory protein isoform d precursor","685",""
11929,11930d11899
< "P97868-1","NP_778188.1","E3 ubiquitin-protein ligase RBBP6 isoform 2","123",""
< "Q9ER69-1","NP_780603.1","pre-mRNA-splicing regulator WTAP isoform b","151",""
11932,11933d11900
< "P48794-1","NP_033267.2","hyaluronidase PH-20 precursor","512",""
< "P62509-1","NP_036065.1","estrogen-related receptor gamma isoform1","458",""
11935d11901
< "O70494-1","NP_001091895.1","transcription factor Sp3 isoform 2","716","This gene product belongs to a family of Sp1 related transcription factors, which regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses transcription of numerous genes. Alternative splicing results in transcript variants encoding different isoforms, and one variant initiates translation from a non-AUG (AUA) codon. [provided by RefSeq, Jul 2008]. "
11937d11902
< "B1AVD1-1","NP_573476.2","xaa-Pro aminopeptidase 2 isoform 1 precursor","674",""
11943a11909
> "Q9QYC0-1","NP_001019629.2","alpha-adducin isoform 1","735",""
11945c11911
< "P56399-1","NP_038728.1","ubiquitin carboxyl-terminal hydrolase 5 isoform 1","858",""
---
> "O08601-1","NP_001156929.1","microsomal triglyceride transfer protein large subunit isoform 1 precursor","909",""
11948,11949c11914
< "P50285-1","NP_034361.1","dimethylaniline monooxygenase [N-oxide-forming] 1 isoform 1","532",""
< "P45878-1","NP_032046.1","peptidyl-prolyl cis-trans isomerase FKBP2 precursor","140",""
---
> "Q8BX57-1","NP_663433.2","PX domain-containing protein kinase-like protein long isoform","582",""
11952c11917
< "O35732-1","NP_997536.1","CASP8 and FADD-like apoptosis regulator isoform 1","481",""
---
> "Q99NH2-1","NP_001013598.1","partitioning defective 3 homolog isoform 2","606",""
11955c11920
< "Q9DBN1-1","NP_083064.2","stimulated by retinoic acid gene 6 protein-like isoform 1","621",""
---
> "Q61107-1","NP_001276421.1","guanylate-binding protein 4","620",""
11961,11962d11925
< "Q9QYC0-1","NP_038485.1","alpha-adducin isoform 2","632",""
< "Q80W04-1","NP_849205.1","transmembrane and coiled-coil domains protein 2 isoform 1","706",""
11965c11928
< "Q91WA1-1","NP_079648.1","TIMELESS-interacting protein","278","The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM and aids in protecting cells against DNA damage and stress. [provided by RefSeq, Feb 2014]. "
---
> "Q61955-1","NP_001311327.1","kallikrein-8 preproprotein","260","This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein exhibit impaired long-term potentiation and increased anxiety, as well as a hyperkeratosis phenotype. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]. "
11967a11931
> "Q9QXE4-1","NP_001186034.1","tumor protein p53-inducible nuclear protein 1 isoform 2","163",""
11971d11934
< "Q99NH2-1","NP_001013599.1","partitioning defective 3 homolog isoform 1","896",""
11974d11936
< "Q99JF8-1","NP_598709.1","PC4 and SFRS1-interacting protein isoform 1","528",""
11978,11979c11940,11941
< "B2RXV4-1","NP_001300676.1","feline leukemia virus subgroup C receptor-related protein 1 isoform 2","414",""
< "Q9ES74-1","NP_067618.1","serine/threonine-protein kinase Nek7 isoform 1","302",""
---
> "Q08879-1","NP_001334017.1","fibulin-1 isoform 2 precursor","685",""
> "Q8CDA1-1","NP_001333446.1","phosphatidylinositide phosphatase SAC2 isoform 2","505",""
11982c11944,11945
< "O08601-1","NP_032668.2","microsomal triglyceride transfer protein large subunit isoform 2 precursor","894",""
---
> "Q9Z2H2-1","NP_001268990.1","regulator of G-protein signaling 6 isoform 2","472","This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP (Dishevelled, Egl-10, and Pleckstrin) and GGL (G-protein gamma like)domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Mice lacking this gene exhibit decreased heart rate. Alternative splicing results in multiple transcript variants, however, the full-length nature of some of these variants is not known. [provided by RefSeq, Sep 2015]. "
> "P11862-1","NP_001317536.1","growth arrest-specific protein 2 isoform 1","314",""
11988a11952
> "Q9D8N2-1","NP_001161301.1","DENN domain-containing protein 10 isoform 2","350",""
11990c11954,11955
< "Q9D8N2-1","NP_080713.2","DENN domain-containing protein 10 isoform 1","357",""
---
> "Q920E5-1","NP_001240680.1","farnesyl pyrophosphate synthase isoform 1 precursor","420",""
> "Q9WTZ9-1","NP_001103703.1","protein BEX3 isoform a","124",""
11992a11958
> "Q9WUB4-1","NP_001280686.1","dynactin subunit 6 isoform 1","195",""
11994d11959
< "Q9WUB4-1","NP_035852.1","dynactin subunit 6 isoform 2","190",""
11996a11962
> "Q8JZP9-1","NP_001177337.1","GAS2-like protein 1 isoform beta","678","This gene encodes a member of the Gas2 family, actin-associated proteins expressed at high levels in growth-arrested cells. The gene expression is negatively regulated by serum and growth factors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]. "
11997a11964,11965
> "E9Q9R9-1","NP_001156985.1","disks large homolog 5 isoform 1","1921",""
> "Q8K3J5-1","NP_001289476.1","zinc finger protein 131 isoform 1","619","This gene encodes a member of the BTB/POZ family of transcription factors. This protein has been found to act as a transcriptional activator and may regulate estrogen receptor signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. "
11999d11966
< "Q6PAR0-1","NP_084018.1","kelch domain-containing protein 10 isoform 1","439",""
12003a11971,11973
> "Q91ZV7-1","NP_001157080.1","plexin domain-containing protein 1 isoform 1 precursor","507",""
> "Q9Z1X0-1","NP_001157518.1","chemokine (C-C motif) ligand 27b isoform 2 precursor","120",""
> "Q80W04-1","NP_001298036.1","transmembrane and coiled-coil domains protein 2 isoform 2","628",""
12006a11977
> "P10755-1","NP_035878.1","zinc finger protein 14","501",""
12008,12009c11979
< "Q9R0Z9-1","NP_056617.2","rho GTPase-activating protein 7 isoform 2","1092",""
< "Q9D6K5-1","NP_079568.1","synaptojanin-2-binding protein isoform 1","145",""
---
> "Q8CG14-1","NP_001091086.1","complement C1s-A subcomponent precursor","694",""
12011c11981,11982
< "P11985-1","NP_932772.1","tctex1 domain-containing protein 3 isoform 2","139","This gene is one of three genes with a very high degree of similarity to each other within a 77 kb genomic span on Chromosome 17 A2. This gene is the most distal copy of the three genes. [provided by RefSeq, Jul 2008]. "
---
> "O70546-1","NP_001297373.1","lysine-specific demethylase 6A isoform 2","1401",""
> "Q99MD9-1","NP_001074944.1","nuclear autoantigenic sperm protein isoform 1","448",""
12015a11987
> "Q9WUR9-1","NP_001171073.1","adenylate kinase 4, mitochondrial","223",""
12021d11992
< "Q9D424-1","NP_859420.2","calcium-binding tyrosine phosphorylation-regulated protein isoform c","381",""
12023a11995
> "Q9DCJ1-1","NP_001239392.1","target of rapamycin complex subunit LST8 isoform 1","326",""
12025a11998
> "P28704-1","NP_001192145.1","retinoic acid receptor RXR-beta isoform 4","410",""
12026a12000
> "P49935-1","NP_001299578.1","pro-cathepsin H isoform 2","263","This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin H mini, heavy, and light chains. In rat and human, these three chains can associate to form the mature enzyme, which has both aminopeptidase and endopeptidase activities. Homozygous knockout mice for this gene exhibit impaired lung surfactant processing and reduced tumorigenesis in a pancreatic cancer model. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]. "
12029,12030c12003
< "Q99JY3-1","NP_778155.2","GTPase IMAP family member 4 isoform a","328","This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. This gene exists within a cluster of other related genes located on mouse chromosome 6. This family member encodes a lymphoid signaling protein that functions to accelerate programmed T-cell death, which appears to correlate with the phosphorylation status of the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]. "
< "Q8CFA1-1","NP_751893.3","interleukin-1 receptor-associated kinase-like 2 isoform a","622",""
---
> "P83940-1","NP_001297399.1","elongin-C isoform 1","134",""
12034,12035d12006
< "Q9QZS2-1","NP_035408.1","E3 ubiquitin-protein ligase RNF4","194","This gene encodes a small nuclear RING finger protein that mediates ubiquitylation of polysumoylated proteins. Deficiency of the encoded protein in mice leads to embryonic lethality and global DNA hypermethylation. A similar protein in humans is required for arsenic-induced degradation of promyelocytic leukemia protein in acute promyelocytic leukemia. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on chromosome 10. [provided by RefSeq, Jan 2015]. "
< "P47857-1","NP_067489.3","ATP-dependent 6-phosphofructokinase, muscle type","780",""
12039d12009
< "Q8R050-1","NP_666178.2","eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 1","636",""
12044c12014
< "P81270-1","NP_598420.1","transcriptional regulator ERG isoform 1","486",""
---
> "Q9JMD1-1","NP_001160003.1","scm-like with four MBT domains protein 1","863",""
12047d12016
< "O88487-1","NP_034194.1","cytoplasmic dynein 1 intermediate chain 2 isoform 5","612",""
12049c12018,12019
< "O88829-1","NP_035505.2","lactosylceramide alpha-2,3-sialyltransferase isoform b","387",""
---
> "Q80TE0-1","NP_001157173.1","RNA polymerase II-associated protein 1 isoform 2","1409",""
> "O35426-1","NP_001258659.1","X-box-binding protein 1 isoform XBP1(S)","371",""
12052,12053c12022,12023
< "Q3UHQ6-1","NP_081569.1","protein dopey-2 isoform 1","2295",""
< "Q64385-1","NP_034679.1","interleukin-11 receptor subunit alpha-1 precursor","432",""
---
> "O89053-1","NP_001288303.1","coronin-1A isoform 1","461","This gene encodes a member of the WD repeat coronin family. The encoded protein may bind actin and interact with microtubules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. "
> "Q5EBH1-1","NP_001298023.1","ras association domain-containing protein 5 isoform 2","265",""
12056a12027
> "Q920H1-2","NP_001276572.1","secretoglobin family 3A member 2 isoform 1","113",""
12059a12031
> "Q61009-1","NP_001192011.1","scavenger receptor class B member 1 isoform 2","506",""
12061c12033
< "Q91WG5-1","NP_663376.2","5'-AMP-activated protein kinase subunit gamma-2 isoform 1","566",""
---
> "Q64385-1","NP_001156873.1","interleukin-11 receptor subunit alpha-1 precursor","432",""
12064,12065d12035
< "P34914-1","NP_031966.2","bifunctional epoxide hydrolase 2 isoform a","554",""
< "Q91ZP3-1","NP_766538.2","phosphatidate phosphatase LPIN1 isoform a","891",""
12067d12036
< "Q9WVL0-1","NP_034493.1","maleylacetoacetate isomerase isoform 1","216",""
12069d12037
< "Q8CJ91-1","NP_081248.4","CD209 antigen-like protein B isoform a","325",""
12070a12039,12040
> "Q8BHL5-1","NP_001289681.1","engulfment and cell motility protein 2 isoform 3","720",""
> "O08842-1","NP_001289023.1","GDNF family receptor alpha-2 isoform 2","359","The protein encoded by this gene is part of the receptor complex that transduces glial cell-derived neurotrophic factor and neurturin signals by mediating autophosphorylation and activation of the RET receptor. Mice lacking this protein are viable and fertile but display growth retardation attributed to impaired salivary and pancreatic secretion and innervation deficits in the intestinal tract. In addition, knockout mice display neural defects including a failure to initiate outgrowth of dorsal ganglion root neurons, demonstrating a requirement in neuronal differentiation of these cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. "
12079a12050,12051
> "Q8CHH9-1","NP_001239261.1","septin-8 isoform 2","429",""
> "Q9D103-1","NP_001106186.1","interferon-induced transmembrane protein 1 isoform a","106",""
12082d12053
< "Q8BPU7-1","NP_932761.1","engulfment and cell motility protein 1 isoform 2","247",""
12083a12055
> "Q63994-1","NP_001104528.1","myeloid cell surface antigen CD33 isoform 1 precursor","403",""
12085d12056
< "P62874-1","NP_032168.1","guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1","340",""
12087d12057
< "Q8K1I7-1","NP_694778.1","WAS/WASL-interacting protein family member 1","493",""
12088a12059
> "Q5XPI3-1","NP_001298081.1","E3 ubiquitin-protein ligase RNF123 isoform 1","1320",""
12090d12060
< "Q99MD9-1","NP_001271158.1","nuclear autoantigenic sperm protein isoform 3","421",""
12095c12065
< "P81615-1","NP_067265.1","urocortin preproprotein","122","This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. Mice lacking the encoded protein exhibit a heightened anxiety-like behaviors and a significantly reduced acoustic startle response. [provided by RefSeq, Sep 2016]. "
---
> "Q8BML1-1","NP_001180234.1","[F-actin]-monooxygenase MICAL2 isoform A","1102",""
12097d12066
< "Q9DCA7-1","NP_081045.2","neuron-specific vesicular protein calcyon","226",""
12098a12068
> "Q6PAR0-1","NP_001298016.1","kelch domain-containing protein 10 isoform 2","410",""
12102d12071
< "Q9D676-1","NP_081838.1","C-type lectin domain family 2 member G isoform 1","269",""
12104,12105d12072
< "Q9ER62-1","NP_076169.2","tumor necrosis factor receptor superfamily member 22 isoform 1","180",""
< "Q9DBS9-1","NP_082157.2","oxysterol-binding protein-related protein 3 isoform 1","855",""
12108,12109c12075,12077
< "Q69ZX8-1","NP_941051.2","actin-binding LIM protein 3 isoform 1","682",""
< "O70546-1","NP_033509.1","lysine-specific demethylase 6A isoform 1","1424",""
---
> "P10166-1","NP_001290050.1","protein L-Myc isoform 2","398","This gene encodes a basic helix-loop-helix leucine zipper (bHLHZip) protein that heterodimerizes with another bHLHZip protein to drive transcription of targets important for proliferation, apoptosis and differentiation. Mice lacking this gene product show marked decrease in T-cell priming during bacterial and viral infections. In humans, this gene was found to be amplified in small-cell lung cancers. Alternate splicing of this gene results in multiple variants. [provided by RefSeq, Dec 2014]. "
> "Q9QZS2-1","NP_001291198.1","E3 ubiquitin-protein ligase RNF4","194","This gene encodes a small nuclear RING finger protein that mediates ubiquitylation of polysumoylated proteins. Deficiency of the encoded protein in mice leads to embryonic lethality and global DNA hypermethylation. A similar protein in humans is required for arsenic-induced degradation of promyelocytic leukemia protein in acute promyelocytic leukemia. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on chromosome 10. [provided by RefSeq, Jan 2015]. "
> "O88485-1","NP_001177952.1","cytoplasmic dynein 1 intermediate chain 1 isoform 2","625",""
12111d12078
< "P70175-1","NP_058027.1","disks large homolog 3 isoform 1","849",""
12118,12120c12085,12087
< "Q9D415-1","NP_808307.2","disks large-associated protein 1 isoform 1","992",""
< "P97946-1","NP_034346.1","vascular endothelial growth factor D isoform VEGF-D358 preproprotein","358","This gene encodes a member of the vascular endothelial growth factor (VEGF) family that acts as a ligand for vascular endothelial growth factor receptor 3. Signalling through this protein is important for growth and development of endothelial and vascular tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]. "
< "Q8R550-1","NP_067364.2","SH3 domain-containing kinase-binding protein 1 isoform 2","628",""
---
> "Q9DBS9-1","NP_001157117.1","oxysterol-binding protein-related protein 3 isoform 2","819",""
> "Q91VZ6-1","NP_001277612.1","stromal membrane-associated protein 1 isoform 2","355",""
> "P19973-1","NP_001129543.1","lymphocyte-specific protein 1 isoform 1","330",""
12122a12090,12091
> "P97434-1","NP_036157.2","myosin phosphatase Rho-interacting protein isoform 2","1024",""
> "Q2WF71-1","NP_001135393.1","leucine-rich repeat and fibronectin type III domain-containing protein 1 isoform 1 precursor","766",""
12126a12096
> "Q9CQ48-1","NP_001277626.1","nudC domain-containing protein 2 isoform 2","132",""
12128a12099
> "Q8CGP2-1","NP_001277395.1","histone H2B type 1-P isoform 2","126","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Aug 2015]. "
12130,12131c12101
< "P35564-1","NP_031623.1","calnexin precursor","591",""
< "O70628-1","NP_032830.3","high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A","534",""
---
> "Q9Z1X4-1","NP_001036172.1","interleukin enhancer-binding factor 3 isoform 2","898","The protein encoded by this gene contains two double-stranded RNA binding domains and functions in the post-transcriptional regulation of gene expression. It is a component of an RNA-protein complex that may be involved in mediating the export of messenger RNAs. Alternative splicing results in multiple transcript variants encoding distinct isoforms. These isoforms are grouped into two categories, NFAR-1 or NFAR-2, based on variation at the C-terminus. [provided by RefSeq, Mar 2013]. "
12132a12103
> "Q9QXA6-1","NP_001185944.1","B(0,+)-type amino acid transporter 1","487",""
12135d12105
< "O09117-1","NP_942003.1","synaptophysin-like protein 1 isoform 2","243",""
12141a12112
> "Q9QYE9-1","NP_001156654.1","pleckstrin homology domain-containing family B member 1 isoform b","208",""
12145,12146d12115
< "Q9Z2Y3-1","NP_687036.1","homer protein homolog 1 isoform d","370",""
< "Q9WUR2-1","NP_035998.2","enoyl-CoA delta isomerase 2, mitochondrial isoform b","358",""
12149c12118,12119
< "Q9WTZ9-1","NP_033880.1","protein BEX3 isoform a","124",""
---
> "P04768-1","NP_035248.2","prolactin-2C3 precursor","224",""
> "Q920G3-1","NP_001257948.1","sialic acid-binding Ig-like lectin 5 isoform 2 precursor","535",""
12151d12120
< "O88485-1","NP_034193.2","cytoplasmic dynein 1 intermediate chain 1 isoform 1","628",""
12153d12121
< "Q0P678-1","NP_001297579.1","zinc finger CCCH domain-containing protein 18 isoform c","950",""
12155a12124
> "Q8BP71-1","NP_001104297.1","RNA binding protein fox-1 homolog 2 isoform 3","445",""
12158d12126
< "Q8K3J5-1","NP_082521.1","zinc finger protein 131 isoform 2","585","This gene encodes a member of the BTB/POZ family of transcription factors. This protein has been found to act as a transcriptional activator and may regulate estrogen receptor signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. "
12161c12129
< "Q60902-1","NP_031970.2","epidermal growth factor receptor substrate 15-like 1 isoform a","907",""
---
> "Q61224-1","NP_001272411.1","5-hydroxytryptamine receptor 1D","374",""
12164c12132
< "Q8BY89-1","NP_690021.1","choline transporter-like protein 2 isoform 2","706",""
---
> "P50247-1","NP_001291457.1","predicted gene 4737","432",""
12167c12135,12136
< "A6H6A9-1","NP_038890.3","rab GTPase-activating protein 1-like isoform a","815",""
---
> "Q924T2-1","NP_001159503.2","28S ribosomal protein S2, mitochondrial isoform 2","272",""
> "O70433-1","NP_001276462.1","four and a half LIM domains protein 2","279","This gene encodes a member of the four-and-a-half-LIM-only protein family. The encoded protein functions as a regulator in numerous signaling pathways and cellular processes in development and cellular differentiation, including development and maintenance of the cardiovascular system and striated muscles. This gene also plays a role in bone formation and regulates and bone mineral content and bone mineral density. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. "
12169,12170c12138
< "Q3UUY6-1","NP_835148.2","prominin-2 isoform 2 precursor","821",""
< "Q9EPQ2-1","NP_076368.1","X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 isoform 1","1331",""
---
> "A6H6A9-1","NP_001033710.1","rab GTPase-activating protein 1-like isoform b","370",""
12175,12177d12142
< "O70433-1","NP_034342.1","four and a half LIM domains protein 2","279","This gene encodes a member of the four-and-a-half-LIM-only protein family. The encoded protein functions as a regulator in numerous signaling pathways and cellular processes in development and cellular differentiation, including development and maintenance of the cardiovascular system and striated muscles. This gene also plays a role in bone formation and regulates and bone mineral content and bone mineral density. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. "
< "Q8BX35-1","NP_780749.3","tumor necrosis factor receptor superfamily member 27","297",""
< "Q9CQG3-1","NP_671708.1","zinc finger MYND domain-containing protein 19 isoform 2","188",""
12179a12145,12146
> "Q9CPU0-1","NP_001107032.1","lactoylglutathione lyase","184",""
> "Q9Z0E3-1","NP_001258478.1","autoimmune regulator isoform 2","551",""
12181d12147
< "Q9D1A2-1","NP_075638.2","cytosolic non-specific dipeptidase","475",""
12183a12150
> "Q60953-1","NP_001298017.1","protein PML isoform 3","632",""
12185a12153
> "P35564-1","NP_001103969.1","calnexin precursor","591",""
12187a12156
> "Q80XE1-2","NP_001013459.1","synembryn-B isoform 1","520",""
12188a12158
> "O35601-1","NP_001265198.1","FYN-binding protein 1 isoform 2","773","The protein encoded by this gene is an adapter molecule that affects T cell receptor signaling and contains multiple protein-protein interaction domains. It is thought to couple T cell receptor stimulation with activation of integrin function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]. "
12192d12161
< "Q920H1-2","NP_001276573.1","secretoglobin family 3A member 2 isoform 2 precursor","91",""
12194d12162
< "O88898-1","NP_035771.1","tumor protein 63 isoform d","586","This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include tumor proteins p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Tumor protein p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.[provided by RefSeq, Dec 2009]. "
12198a12167
> "Q9JLJ4-1","NP_001298050.1","elongation of very long chain fatty acids protein 2 isoform 2","275",""
12201d12169
< "Q9WVM1-1","NP_036155.1","rac GTPase-activating protein 1","628",""
12204,12205c12172
< "Q5EBH1-1","NP_061220.2","ras association domain-containing protein 5 isoform 1","413",""
< "P48168-1","NP_034428.2","glycine receptor subunit beta isoform 4 precursor","496","This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. This gene is transcribed throughout the central nervous system of neonatal and adult mice. In humans, mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. "
---
> "Q8BR65-1","NP_001116138.1","sin3 histone deacetylase corepressor complex component SDS3 isoform b","332",""
12207d12173
< "F2Z472-1","NP_001298043.1","seminal vesicle secretory protein 3A isoform 2 precursor","264",""
12211a12178
> "P47857-1","NP_001156959.1","ATP-dependent 6-phosphofructokinase, muscle type","780",""
12213a12181
> "P48379-1","NP_033082.1","DNA-binding protein RFX2 isoform 2","692",""
12216,12217d12183
< "Q9CPU0-1","NP_079650.3","lactoylglutathione lyase","184",""
< "O54804-1","NP_038518.2","choline kinase alpha isoform 1","435",""
12223d12188
< "Q920G3-1","NP_663556.1","sialic acid-binding Ig-like lectin 5 isoform 1 precursor","569",""
12227,12228d12191
< "Q9JMD1-1","NP_062333.1","scm-like with four MBT domains protein 1","863",""
< "Q9JM52-1","NP_795712.2","misshapen-like kinase 1 isoform 2","1308",""
12230d12192
< "Q61609-1","NP_056562.1","sodium-dependent phosphate transporter 1 isoform 1","681",""
12234a12197,12198
> "Q8R4T9-1","NP_001103744.1","urea transporter 2 isoform d","323",""
> "O88487-1","NP_001185805.1","cytoplasmic dynein 1 intermediate chain 2 isoform 5","612",""
12236d12199
< "Q5XJV6-1","NP_001277919.1","serine/threonine-protein kinase LMTK3 precursor","1424",""
12238d12200
< "Q9D9V2-1","NP_081365.2","equatorin isoform 1 precursor","337",""
12241d12202
< "P50247-1","NP_057870.3","adenosylhomocysteinase","432",""
12245c12206
< "Q9D2Z4-1","NP_082114.1","sentrin-specific protease 8 isoform a","221",""
---
> "Q3TZX8-1","NP_001153071.1","polynucleotide 5'-hydroxyl-kinase NOL9 isoform 1","714",""
12246a12208
> "Q8R4T1-1","NP_001004455.2","cystin-1","145",""
12249c12211
< "Q6P6I6-1","NP_848717.1","DNA-directed RNA polymerase II subunit GRINL1A isoform 1","366",""
---
> "Q91XT4-1","NP_001153458.1","protein transport protein Sec16B","1051",""
12252,12254d12213
< "Q91VZ6-1","NP_082810.1","stromal membrane-associated protein 1 isoform 1","440",""
< "Q8BX17-1","NP_766146.2","gem-associated protein 5 isoform 2","1502",""
< "Q62293-1","NP_035709.3","T-cell-specific guanine nucleotide triphosphate-binding protein 1","415",""
12257c12216
< "O08575-1","NP_034295.1","eyes absent homolog 2","532","This gene encodes a member of the eyes absent protein family. The encoded protein is a tyrosine phosphatase which acts as a transcriptional activator during development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]. "
---
> "O88569-1","NP_058086.2","heterogeneous nuclear ribonucleoproteins A2/B1 isoform 1","341",""
12260a12220
> "Q64702-1","NP_035625.2","serine/threonine-protein kinase PLK4 isoform 1","925","This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to the nucleolus during G2, to centrosomes during G2/M, and to the cleavage furrow during cytokinesis. It is required for progression through mitosis, cell survival, and embryonic development. The mouse genome contains a pseudogene similar to this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]. "
12261a12222
> "Q8K1I7-1","NP_001276651.1","WAS/WASL-interacting protein family member 1","493",""
12263a12225
> "Q9WUR2-1","NP_001103801.1","enoyl-CoA delta isomerase 2, mitochondrial isoform a","391",""
12265,12266c12227
< "P10166-1","NP_032532.1","protein L-Myc isoform 1","368","This gene encodes a basic helix-loop-helix leucine zipper (bHLHZip) protein that heterodimerizes with another bHLHZip protein to drive transcription of targets important for proliferation, apoptosis and differentiation. Mice lacking this gene product show marked decrease in T-cell priming during bacterial and viral infections. In humans, this gene was found to be amplified in small-cell lung cancers. Alternate splicing of this gene results in multiple variants. [provided by RefSeq, Dec 2014]. "
< "P17182-1","NP_075608.2","alpha-enolase","434",""
---
> "P97946-1","NP_001295418.1","vascular endothelial growth factor D isoform VEGF-D326 preproprotein","326","This gene encodes a member of the vascular endothelial growth factor (VEGF) family that acts as a ligand for vascular endothelial growth factor receptor 3. Signalling through this protein is important for growth and development of endothelial and vascular tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]. "
12267a12229,12230
> "Q9D676-1","NP_001161695.1","C-type lectin domain family 2 member G isoform 2","212",""
> "P81270-1","NP_001289081.1","transcriptional regulator ERG isoform 2","462",""
12272c12235,12237
< "Q9WUR9-1","NP_033777.1","adenylate kinase 4, mitochondrial","223",""
---
> "O55186-1","NP_001104530.1","CD59A glycoprotein precursor","123",""
> "Q8R550-1","NP_001129199.1","SH3 domain-containing kinase-binding protein 1 isoform 1","665",""
> "Q91WG5-1","NP_001164027.1","5'-AMP-activated protein kinase subunit gamma-2 isoform 3","326",""
12273a12239,12240
> "Q9WVC6-1","NP_001155317.2","serine/threonine-protein kinase Sgk1 isoform a","524","This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. This enzyme is activated by protein phosphorylation and degraded via the ubiquitination and proteasome pathway. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 12. [provided by RefSeq, Sep 2009]. "
> "Q9ER62-1","NP_001298074.1","tumor necrosis factor receptor superfamily member 22 isoform 2","198",""
12279d12245
< "O35426-1","NP_038870.2","X-box-binding protein 1 isoform XBP1(U)","267",""
12282d12247
< "Q9WVB0-1","NP_062707.1","RNA-binding protein with multiple splicing isoform 1","197",""
12286a12252
> "P18581-1","NP_001038205.1","cationic amino acid transporter 2 isoform 2","658",""
12289d12254
< "Q80XU3-1","NP_780503.2","nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform 1","234",""
12293c12258
< "O55186-1","NP_031678.1","CD59A glycoprotein precursor","123",""
---
> "Q9QZ47-1","NP_001157137.1","troponin T, fast skeletal muscle isoform 2","272",""
12295d12259
< "P48379-1","NP_082063.1","DNA-binding protein RFX2 isoform 1","717",""
12297a12262
> "Q62470-1","NP_001293000.1","integrin alpha-3 isoform 2","1022","This gene encodes a subunit of integrin family of cell surface proteins. The encoded protein undergoes post-translational processing to form a disulfide bond-linked dimer comprised of heavy and light chains. At the cell surface, the encoded protein non-covalently associates with the integrin beta-1 subunit to form a heterodimer that interacts with many extracellular matrix proteins including fibronectin and laminin. Mice lacking the encoded protein die during the first day after birth due to severe abnormalities in kidneys. Mice lacking the encoded protein specifically in the basal layer of epidermis display several skin defects and accelerated wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. "
12300,12303c12265
< "Q3UPF5-1","NP_083140.1","zinc finger CCCH-type antiviral protein 1 isoform 2","789",""
< "P10755-1","NP_848848.1","zinc finger protein 14","501",""
< "Q63994-1","NP_067268.1","myeloid cell surface antigen CD33 isoform 2 precursor","334",""
< "O89053-1","NP_034028.1","coronin-1A isoform 1","461","This gene encodes a member of the WD repeat coronin family. The encoded protein may bind actin and interact with microtubules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. "
---
> "P0DPB4-1","NP_001106891.1","schwannomin-interacting protein 1 isoform b","256",""
12304a12267
> "P34928-1","NP_001103479.1","apolipoprotein C-I precursor","88","This gene encodes a precursor plasma protein that is cleaved to yield a signal peptide and two alternatively processed mature peptides. The encoded protein, which is a component of chylomicrons, very low density lipoproteins and high density lipoproteins, transports lipids from the intestines to other locations in the body. This protein binds to free fatty acids preventing their uptake by cells. This protein is a cofactor for lecithin cholesterol acyltransferase, an enzyme that catalyzes the conversion of free cholesterol to cholesteryl esters. The encoded protein inhibits the activity of the cholesteryl ester transfer protein which promotes the exchange of neutral lipids between lipoproteins. In humans this gene is associated with risk of coronary artery disease and age-associated memory impairment. Mice lacking this gene demonstrate impaired memory. This gene is clustered with three other apolipoprotein genes on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]. "
12305a12269
> "Q61469-1","NP_032273.1","phospholipid phosphatase 1 isoform 1","284",""
12307,12309d12270
< "O88786-1","NP_032382.1","interleukin-13 receptor subunit alpha-2 isoform 1 precursor","383","This gene encodes a receptor protein that binds to interleukin 13 (IL-13) with very high affinity. The encoded protein acts as a decoy receptor, and does not elicit any signal upon the binding of IL-13. Mice lacking the encoded protein exhibit increased levels of serum immunoglobulins, immune-dependent production of interferon gamma and, increased bone marrow macrophage progenitor frequency. Macrophages lacking the encoded protein release less nitric oxide and IL-12 in response to lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. "
< "Q8VBX6-1","NP_034950.2","multiple PDZ domain protein isoform 2","2055",""
< "Q8R0W1-1","NP_776096.2","CLOCK-interacting pacemaker isoform a","411",""
12313d12273
< "P97434-1","NP_957697.1","myosin phosphatase Rho-interacting protein isoform 1","1037",""
12315a12276
> "Q5XJV6-1","NP_001005511.2","serine/threonine-protein kinase LMTK3 precursor","1424",""
12319c12280
< "O08842-1","NP_032141.2","GDNF family receptor alpha-2 isoform 1 preproprotein","464","The protein encoded by this gene is part of the receptor complex that transduces glial cell-derived neurotrophic factor and neurturin signals by mediating autophosphorylation and activation of the RET receptor. Mice lacking this protein are viable and fertile but display growth retardation attributed to impaired salivary and pancreatic secretion and innervation deficits in the intestinal tract. In addition, knockout mice display neural defects including a failure to initiate outgrowth of dorsal ganglion root neurons, demonstrating a requirement in neuronal differentiation of these cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. "
---
> "P62874-1","NP_001153488.1","guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1","340",""
12324c12285,12286
< "Q8C0L9-1","NP_083078.3","glycerophosphocholine phosphodiesterase GPCPD1 isoform 2","675",""
---
> "Q9D2Z4-1","NP_001165539.1","sentrin-specific protease 8 isoform a","221",""
> "Q3USJ8-1","NP_001139482.1","F-BAR and double SH3 domains protein 2 isoform 2","740",""
12326,12327c12288,12289
< "Q9QZ47-1","NP_035750.2","troponin T, fast skeletal muscle isoform 7","248",""
< "Q64702-1","NP_775261.2","serine/threonine-protein kinase PLK4 isoform 2","898","This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to the nucleolus during G2, to centrosomes during G2/M, and to the cleavage furrow during cytokinesis. It is required for progression through mitosis, cell survival, and embryonic development. The mouse genome contains a pseudogene similar to this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]. "
---
> "Q9WVF9-1","NP_001276635.1","C-type lectin domain family 2 member I isoform 1","246",""
> "Q8R050-1","NP_001123480.1","eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 2","635",""
12330c12292,12293
< "Q9JIZ9-1","NP_076053.1","phospholipid scramblase 3","296",""
---
> "Q9QYP6-1","NP_001041611.1","5-azacytidine-induced protein 2 isoform b","283",""
> "P35803-1","NP_001171426.1","neuronal membrane glycoprotein M6-b isoform 1","328",""
12332d12294
< "Q9Z238-1","NP_033960.1","G1/S-specific cyclin-E2 isoform 2","403",""
12334d12295
< "O35601-1","NP_035945.1","FYN-binding protein 1 isoform 1","819","The protein encoded by this gene is an adapter molecule that affects T cell receptor signaling and contains multiple protein-protein interaction domains. It is thought to couple T cell receptor stimulation with activation of integrin function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]. "
12335a12297
> "Q9DCB1-1","NP_080398.1","high mobility group nucleosome-binding domain-containing protein 3 isoform Hmgn3a","99",""
12338,12339d12299
< "Q8VDK1-1","NP_036179.1","deaminated glutathione amidase isoform 1","323",""
< "Q9DCJ1-1","NP_064372.2","target of rapamycin complex subunit LST8 isoform 1","326",""
12340a12301
> "Q9CQG3-1","NP_080297.1","zinc finger MYND domain-containing protein 19 isoform 1","227",""
12342,12343c12303
< "Q61009-1","NP_058021.1","scavenger receptor class B member 1 isoform 1","509",""
< "P49935-1","NP_031827.2","pro-cathepsin H isoform 1 preproprotein","333","This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin H mini, heavy, and light chains. In rat and human, these three chains can associate to form the mature enzyme, which has both aminopeptidase and endopeptidase activities. Homozygous knockout mice for this gene exhibit impaired lung surfactant processing and reduced tumorigenesis in a pancreatic cancer model. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]. "
---
> "P36993-1","NP_001152969.1","protein phosphatase 1B isoform 3","390",""
12344a12305
> "P24604-1","NP_001106931.1","tyrosine-protein kinase Tec isoform a","630",""
12346c12307
< "Q8K1E3-1","NP_001272957.1","protein delta homolog 2 precursor","382",""
---
> "Q8K4Z0-1","NP_001297533.1","leucine-rich repeat LGI family member 2 isoform 2 precursor","542",""
12349d12309
< "Q8JZP9-1","NP_653146.1","GAS2-like protein 1 isoform beta","678","This gene encodes a member of the Gas2 family, actin-associated proteins expressed at high levels in growth-arrested cells. The gene expression is negatively regulated by serum and growth factors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]. "
12351c12311
< "P62484-1","NP_937760.1","abl interactor 2 isoform 3","446",""
---
> "Q9D1A2-1","NP_001276460.1","cytosolic non-specific dipeptidase","475",""
12353,12354c12313
< "A2AFR3-1","NP_001277357.1","FERM and PDZ domain-containing protein 4 isoform b","1280",""
< "Q6P2K6-1","NP_997594.1","serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform 1","820",""
---
> "Q9JM52-1","NP_057922.2","misshapen-like kinase 1 isoform 1","1300",""
12356,12357d12314
< "Q924T2-1","NP_536700.3","28S ribosomal protein S2, mitochondrial isoform 1","291",""
< "Q924W7-1","NP_084087.2","suppression of tumorigenicity 5 protein isoform 2","717",""
12361d12317
< "Q922W5-1","NP_659044.1","pyrroline-5-carboxylate reductase 1, mitochondrial","309",""
12363d12318
< "Q9DCB1-1","NP_778249.1","high mobility group nucleosome-binding domain-containing protein 3 isoform Hmgn3b","77",""
12365,12366d12319
< "P56857-1","NP_062789.1","claudin-18 isoform A1.1 precursor","264","This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is a downstream target gene regulated by the T/EBP/NKX2.1 homeodomain transcription factor. Four alternatively spliced transcript variants resulted from alternative promoters and alternative splicing have been identified, which encode two lung-specific isoforms and two stomach-specific isoforms respectively. This gene is also expressed in colons, inner ear and skin, and its expression is increased in both experimental colitis and ulcerative colitis. [provided by RefSeq, Aug 2010]. "
< "Q61137-1","NP_031521.2","astrotactin-1 isoform 2 precursor","1294",""
12368d12320
< "Q61224-1","NP_032335.2","5-hydroxytryptamine receptor 1D","374",""
12369a12322,12324
> "Q9DCA7-1","NP_001177314.1","neuron-specific vesicular protein calcyon","226",""
> "Q9QZM8-1","NP_001297616.1","F-box only protein 17 isoform 2","242",""
> "P97300-2","NP_001280602.1","neuroplastin isoform 2 precursor","277",""
12372,12373c12327,12330
< "Q9CQ85-1","NP_075844.1","mitochondrial import inner membrane translocase subunit Tim22 isoform 2","170",""
< "Q62470-1","NP_038593.1","integrin alpha-3 isoform 1 preproprotein","1053","This gene encodes a subunit of integrin family of cell surface proteins. The encoded protein undergoes post-translational processing to form a disulfide bond-linked dimer comprised of heavy and light chains. At the cell surface, the encoded protein non-covalently associates with the integrin beta-1 subunit to form a heterodimer that interacts with many extracellular matrix proteins including fibronectin and laminin. Mice lacking the encoded protein die during the first day after birth due to severe abnormalities in kidneys. Mice lacking the encoded protein specifically in the basal layer of epidermis display several skin defects and accelerated wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. "
---
> "Q9WVM1-1","NP_001240737.1","rac GTPase-activating protein 1","628",""
> "Q9WVB0-1","NP_001036139.1","RNA-binding protein with multiple splicing isoform 1","197",""
> "O09117-1","NP_038663.2","synaptophysin-like protein 1 isoform 1","261",""
> "Q9JI67-1","NP_001116465.1","beta-1,3-galactosyltransferase 5","308",""
12375a12333
> "Q3UHQ6-1","NP_080976.1","protein dopey-2 isoform 2","182",""
12378a12337
> "Q03958-1","NP_001172111.1","prefoldin subunit 6","127",""
12381,12382c12340,12341
< "Q9JI67-1","NP_149161.1","beta-1,3-galactosyltransferase 5","308",""
< "Q01887-1","NP_038677.3","tyrosine-protein kinase RYK isoform 1 precursor","594",""
---
> "Q811W2-1","NP_001171184.1","cytochrome P450 26B1","512",""
> "Q9D9V2-1","NP_001277552.1","equatorin isoform 2 precursor","296",""
12383a12343
> "Q7TQ95-1","NP_001103679.1","endoplasmic reticulum junction formation protein lunapark isoform b","376",""
12387c12347
< "Q2VPU4-1","NP_808250.1","MLX-interacting protein isoform 1","614",""
---
> "Q8R088-1","NP_001171140.1","Golgi phosphoprotein 3-like isoform 2","280",""
12389a12350
> "Q8VH51-1","NP_001278043.1","RNA-binding protein 39 isoform b","524",""
12391,12392c12352
< "P42682-1","NP_001276424.1","tyrosine-protein kinase TXK isoform 4","473",""
< "Q8R4T1-1","NP_619627.3","cystin-1","145",""
---
> "Q8CFA1-1","NP_001107025.1","interleukin-1 receptor-associated kinase-like 2 isoform b","574",""
12393a12354,12355
> "O89093-1","NP_001153210.1","C-C motif chemokine 20 isoform 2 precursor","96",""
> "Q9ES74-1","NP_001298077.1","serine/threonine-protein kinase Nek7 isoform 2","201",""
12395a12358
> "Q8K1E3-1","NP_001272942.1","protein delta homolog 2 precursor","382",""
12396a12360
> "Q9D6K5-1","NP_001296743.1","synaptojanin-2-binding protein isoform 2","118",""
12402d12365
< "E9Q9R9-1","NP_082002.1","disks large homolog 5 isoform 2","1898",""
12405d12367
< "Q7TQ95-1","NP_081409.1","endoplasmic reticulum junction formation protein lunapark isoform a","425",""
12408d12369
< "Q91XT4-1","NP_203505.3","protein transport protein Sec16B","1051",""
12411a12373
> "Q61609-1","NP_001153065.1","sodium-dependent phosphate transporter 1 isoform 2","245",""
12413c12375,12376
< "Q8BR65-1","NP_848737.3","sin3 histone deacetylase corepressor complex component SDS3 isoform a","328",""
---
> "Q8CJ91-1","NP_001032889.3","CD209 antigen-like protein B isoform b","295",""
> "Q924W7-1","NP_001001326.1","suppression of tumorigenicity 5 protein isoform 1","1134",""
12415,12416d12377
< "O54915-1","NP_035066.1","nuclear receptor subfamily 1 group I member 2 isoform 1","431",""
< "Q2WF71-1","NP_085039.2","leucine-rich repeat and fibronectin type III domain-containing protein 1 isoform 2 precursor","492",""
12418d12378
< "Q9JJV0-1","NP_067326.1","beta-crystallin A4 isoform 1","196","This gene encodes a member of the crystallin family of proteins that contribute to the transparency and refractive properties of the ocular lens. Certain mutations in the human ortholog of this gene are associated with cataract and bilateral microphthalmia. This gene is located adjacent to a related crystallin gene on chromosome 5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]. "
12421,12422d12380
< "P02762-1","NP_001268908.1","major urinary protein 6 precursor","180",""
< "Q9WUC3-1","NP_035967.1","lymphocyte antigen 6H isoform a precursor","160",""
12424d12381
< "Q9JII7-1","NP_579927.1","AN1-type zinc finger protein 2A","171",""
12426d12382
< "Q9Z0E3-1","NP_033776.1","autoimmune regulator isoform 1","552",""
12430d12385
< "Q9CQ48-1","NP_080299.4","nudC domain-containing protein 2 isoform 1","157",""
12432c12387
< "Q920E5-1","NP_608219.1","farnesyl pyrophosphate synthase isoform 2","353",""
---
> "Q9DBN1-1","NP_001292350.1","stimulated by retinoic acid gene 6 protein-like isoform 2","530",""
12434c12389
< "P0DPB4-1","NP_038956.2","schwannomin-interacting protein 1 isoform d","244",""
---
> "P46737-1","NP_001159929.1","lys-63-specific deubiquitinase BRCC36","291",""
12439a12395
> "Q8BPU7-1","NP_525027.1","engulfment and cell motility protein 1 isoform 3","727",""
12441d12396
< "Q80XE1-2","NP_898995.1","synembryn-B isoform 2","560",""
12442a12398
> "O54915-1","NP_001091874.1","nuclear receptor subfamily 1 group I member 2 isoform 2","390",""
12446d12401
< "Q9WVC6-1","NP_035491.1","serine/threonine-protein kinase Sgk1 isoform e","431","This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. This enzyme is activated by protein phosphorylation and degraded via the ubiquitination and proteasome pathway. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 12. [provided by RefSeq, Sep 2009]. "
12448d12402
< "Q9Z0P4-1","NP_075617.3","paralemmin-1 isoform 1","383",""
12450a12405
> "O88786-1","NP_001292988.1","interleukin-13 receptor subunit alpha-2 isoform 2 precursor","339","This gene encodes a receptor protein that binds to interleukin 13 (IL-13) with very high affinity. The encoded protein acts as a decoy receptor, and does not elicit any signal upon the binding of IL-13. Mice lacking the encoded protein exhibit increased levels of serum immunoglobulins, immune-dependent production of interferon gamma and, increased bone marrow macrophage progenitor frequency. Macrophages lacking the encoded protein release less nitric oxide and IL-12 in response to lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. "
12453c12408,12410
< "Q8BP71-1","NP_780596.1","RNA binding protein fox-1 homolog 2 isoform 2","435",""
---
> "O88898-1","NP_001120731.1","tumor protein 63 isoform a","680","This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include tumor proteins p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Tumor protein p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.[provided by RefSeq, Dec 2009]. "
> "Q9Z238-1","NP_001032211.1","G1/S-specific cyclin-E2 isoform 1","404",""
> "Q91XT6-1","NP_001076445.1","tandem C2 domains nuclear protein","489",""
12457d12413
< "O88569-1","NP_872591.1","heterogeneous nuclear ribonucleoproteins A2/B1 isoform 2","301",""
12463,12464d12418
< "O35453-1","NP_032307.2","serine protease hepsin isoform 2 precursor","416","This gene encodes a type II transmembrane serine protease that may function in diverse processes, including regulation of cell growth. Deficiency in this gene results in hearing loss. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]. "
< "Q91XT6-1","NP_083200.1","tandem C2 domains nuclear protein","489",""
12466a12421
> "P00520-1","NP_001106174.1","tyrosine-protein kinase ABL1 isoform a","1142",""
12468d12422
< "Q8BML1-1","NP_796256.1","[F-actin]-monooxygenase MICAL2 isoform B","960",""
12469a12424
> "Q8R1H0-1","NP_001153372.1","homeodomain-only protein","73",""
12476a12432
> "O88829-1","NP_001030305.1","lactosylceramide alpha-2,3-sialyltransferase isoform a","414",""
12481d12436
< "Q9Z1J2-1","NP_035979.1","serine/threonine-protein kinase Nek4 isoform 1","792",""
12484,12486c12439
< "Q9QYP6-1","NP_038755.1","5-azacytidine-induced protein 2 isoform a","405",""
< "P36993-1","NP_035281.1","protein phosphatase 1B isoform 2","390",""
< "Q03958-1","NP_034515.1","prefoldin subunit 6","127",""
---
> "O70628-1","NP_001157220.1","high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A","534",""
12487a12441
> "Q9JLL3-1","NP_001157627.1","tumor necrosis factor receptor superfamily member 19 precursor","416",""
12489a12444
> "Q8BX35-1","NP_001154904.1","tumor necrosis factor receptor superfamily member 27","297",""
12492d12446
< "Q9Z329-1","NP_064307.2","inositol 1,4,5-trisphosphate receptor type 2 isoform 1","2701",""
12494c12448,12453
< "Q61469-1","NP_032929.1","phospholipid phosphatase 1 isoform 2","283",""
---
> "Q9R0Z9-1","NP_001181870.1","rho GTPase-activating protein 7 isoform 3","1126",""
> "Q9JJV0-1","NP_001299813.1","beta-crystallin A4 isoform 2","183","This gene encodes a member of the crystallin family of proteins that contribute to the transparency and refractive properties of the ocular lens. Certain mutations in the human ortholog of this gene are associated with cataract and bilateral microphthalmia. This gene is located adjacent to a related crystallin gene on chromosome 5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]. "
> "Q62137-1","NP_001177759.1","tyrosine-protein kinase JAK3","1100",""
> "P62484-1","NP_001185499.1","abl interactor 2 isoform 1","487",""
> "Q9JID9-1","NP_001289867.1","SH2B adapter protein 2 isoform 1","621",""
> "P70175-1","NP_001171249.1","disks large homolog 3 isoform 2","835",""
12497a12457
> "Q69ZX8-1","NP_001157963.1","actin-binding LIM protein 3 isoform 1","682",""
12499d12458
< "Q9JKV9-1","NP_067355.1","interleukin-20 isoform 1 precursor","176",""
12503a12463
> "Q80X76-1","NP_001028507.2","serine protease inhibitor A3F","445",""
12505,12506d12464
< "Q62137-1","NP_034719.2","tyrosine-protein kinase JAK3","1100",""
< "Q8R088-1","NP_666245.2","Golgi phosphoprotein 3-like isoform 1","343",""
12507a12466
> "Q9JIZ9-1","NP_001161969.1","phospholipid scramblase 3","296",""
12509c12468,12470
< "Q9JHG2-1","NP_997532.1","calcipressin-2 isoform 1","243",""
---
> "Q9EPQ2-1","NP_001161987.1","X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 isoform 2","1127",""
> "Q8R310-1","NP_001162155.1","transmembrane and coiled-coil domain protein 3 isoform b","446",""
> "P42682-1","NP_001116226.1","tyrosine-protein kinase TXK isoform 1","527",""
12512c12473
< "Q8CG14-1","NP_659187.2","complement C1s-A subcomponent precursor","694",""
---
> "Q9JII7-1","NP_001153380.1","AN1-type zinc finger protein 2A","171",""
12513a12475
> "Q8CI08-1","NP_001106894.1","SLAIN motif-containing protein 2 isoform b","581",""
12517d12478
< "Q8JZL0-1","NP_065614.2","zinc finger protein 467 isoform a","594",""
12519d12479
< "Q6ZPE2-1","NP_001164032.1","myotubularin-related protein 5 isoform 1","1893",""
12523,12525c12483,12485
< "Q8R1H0-1","NP_783199.1","homeodomain-only protein","73",""
< "P24604-1","NP_001106935.1","tyrosine-protein kinase Tec isoform a","630",""
< "Q9WVF9-1","NP_064653.1","C-type lectin domain family 2 member I isoform 2","217",""
---
> "O08575-1","NP_001258891.1","eyes absent homolog 2","532","This gene encodes a member of the eyes absent protein family. The encoded protein is a tyrosine phosphatase which acts as a transcriptional activator during development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]. "
> "Q9D424-1","NP_001035883.1","calcium-binding tyrosine phosphorylation-regulated protein isoform a","453",""
> "F2Z472-1","NP_067338.2","seminal vesicle secretory protein 3A isoform 1 precursor","265",""
12527a12488
> "Q9Z329-1","NP_034716.1","inositol 1,4,5-trisphosphate receptor type 2 isoform 2","2668",""
12533d12493
< "P19973-1","NP_062264.1","lymphocyte-specific protein 1 isoform 2","328",""
12536,12539c12496
< "Q5SSL4-1","NP_942598.1","active breakpoint cluster region-related protein isoform 3","859",""
< "Q02819-1","NP_032775.1","nucleobindin-1 isoform 2 precursor","455",""
< "Q8CGP2-1","NP_835509.2","histone H2B type 1-P isoform 1","138","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Aug 2015]. "
< "P35803-1","NP_075611.1","neuronal membrane glycoprotein M6-b isoform 4","269",""
---
> "Q8VDK1-1","NP_001229509.1","deaminated glutathione amidase isoform 2","290",""
12548c12505
< "P18581-1","NP_031540.2","cationic amino acid transporter 2 isoform 1","657",""
---
> "Q3UPF5-1","NP_082697.1","zinc finger CCCH-type antiviral protein 1 isoform 1","946",""
12549a12507
> "Q9CQ85-1","NP_001278090.1","mitochondrial import inner membrane translocase subunit Tim22 isoform 3","141",""
12552,12553d12509
< "Q8CHH9-1","NP_149156.1","septin-8 isoform 1","430",""
< "Q80TE0-1","NP_796268.3","RNA polymerase II-associated protein 1 isoform 1","1409",""
12555c12511,12512
< "Q8VH51-1","NP_573505.2","RNA-binding protein 39 isoform a","530",""
---
> "P56857-1","NP_001181850.1","claudin-18 isoform A2.1","264","This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is a downstream target gene regulated by the T/EBP/NKX2.1 homeodomain transcription factor. Four alternatively spliced transcript variants resulted from alternative promoters and alternative splicing have been identified, which encode two lung-specific isoforms and two stomach-specific isoforms respectively. This gene is also expressed in colons, inner ear and skin, and its expression is increased in both experimental colitis and ulcerative colitis. [provided by RefSeq, Aug 2010]. "
> "Q61137-1","NP_001192133.1","astrotactin-1 isoform 1 precursor","1302",""
12556a12514,12515
> "Q8BX17-1","NP_001160141.1","gem-associated protein 5 isoform 1","1503",""
> "Q3UUY6-1","NP_620089.2","prominin-2 isoform 1 precursor","835",""
12558d12516
< "P14152-1","NP_032644.3","malate dehydrogenase, cytoplasmic isoform Mdh1","334","This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. A pseudogene has been identified on chromosomes 12. [provided by RefSeq, Feb 2016]. "
12560c12518
< "A2AWA9-1","NP_666233.2","rab GTPase-activating protein 1 isoform a","1064",""
---
> "Q8C0L9-1","NP_001277979.1","glycerophosphocholine phosphodiesterase GPCPD1 isoform 1","491",""
12561a12520
> "Q6P2K6-1","NP_001153686.1","serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform 2","833",""
12562a12522
> "Q9JHG2-1","NP_001273583.1","calcipressin-2 isoform 2","197",""
12565,12566c12525
< "Q9JK91-1","NP_081086.2","DNA mismatch repair protein Mlh1 isoform 1","760",""
< "Q9JID9-1","NP_061295.2","SH2B adapter protein 2 isoform 1","621",""
---
> "Q02819-1","NP_001157134.1","nucleobindin-1 isoform 1 precursor","459",""
12567a12527
> "Q8JZL0-1","NP_001078884.1","zinc finger protein 467 isoform a","594",""
12569c12529
< "P00520-1","NP_033724.2","tyrosine-protein kinase ABL1 isoform b","1123",""
---
> "P61979-1","NP_001288269.1","heterogeneous nuclear ribonucleoprotein K isoform 1","464","The protein encoded by this gene is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, and is a poly-cytosine binding protein (PCBP). It is found in multiple subcellular compartments including the nucleus, cytoplasm and mitochondria. This gene product is thought to interact with RNA, DNA, and protein, and is involved in multiple cellular processes, including transcription, chromatin remodeling, DNA damage response, signal transduction, mRNA splicing, export, and translation. Multiple transcript variants and protein isoforms exist, with some isoforms containing a unique C-terminus. There are four pseudogenes of this gene, found on chromosomes 2, 3, 7 and 13. [provided by RefSeq, Aug 2014]. "
12572,12575d12531
< "P61979-1","NP_079555.1","heterogeneous nuclear ribonucleoprotein K isoform 2","463","The protein encoded by this gene is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, and is a poly-cytosine binding protein (PCBP). It is found in multiple subcellular compartments including the nucleus, cytoplasm and mitochondria. This gene product is thought to interact with RNA, DNA, and protein, and is involved in multiple cellular processes, including transcription, chromatin remodeling, DNA damage response, signal transduction, mRNA splicing, export, and translation. Multiple transcript variants and protein isoforms exist, with some isoforms containing a unique C-terminus. There are four pseudogenes of this gene, found on chromosomes 2, 3, 7 and 13. [provided by RefSeq, Aug 2014]. "
< "O89093-1","NP_058656.1","C-C motif chemokine 20 isoform 1 precursor","97",""
< "Q80X76-1","NP_001161767.1","serine protease inhibitor A3F","445",""
< "Q9QXA6-1","NP_067266.1","B(0,+)-type amino acid transporter 1","487",""
12578c12534
< "Q8BHL5-1","NP_997589.1","engulfment and cell motility protein 2 isoform 2","732",""
---
> "Q9JKV9-1","NP_001298020.1","interleukin-20 isoform 2","154",""
12583c12539,12541
< "Q9D103-1","NP_081096.3","interferon-induced transmembrane protein 1 isoform a","106",""
---
> "Q6P6I6-1","NP_001158265.1","DNA-directed RNA polymerase II subunit GRINL1A isoform 2","262",""
> "Q6ZPE2-1","NP_001074499.2","myotubularin-related protein 5 isoform 2","1867",""
> "Q2VPU4-1","NP_598678.2","MLX-interacting protein isoform 2","917",""
12586d12543
< "Q8CI08-1","NP_705795.2","SLAIN motif-containing protein 2 isoform a","607",""
12595d12551
< "Q811W2-1","NP_780684.1","cytochrome P450 26B1","512",""
12598d12553
< "Q91ZV7-1","NP_082475.3","plexin domain-containing protein 1 isoform 2 precursor","500",""
12600,12601c12555
< "Q8R310-1","NP_796000.1","transmembrane and coiled-coil domain protein 3 isoform b","446",""
< "P34928-1","NP_031495.1","apolipoprotein C-I precursor","88","This gene encodes a precursor plasma protein that is cleaved to yield a signal peptide and two alternatively processed mature peptides. The encoded protein, which is a component of chylomicrons, very low density lipoproteins and high density lipoproteins, transports lipids from the intestines to other locations in the body. This protein binds to free fatty acids preventing their uptake by cells. This protein is a cofactor for lecithin cholesterol acyltransferase, an enzyme that catalyzes the conversion of free cholesterol to cholesteryl esters. The encoded protein inhibits the activity of the cholesteryl ester transfer protein which promotes the exchange of neutral lipids between lipoproteins. In humans this gene is associated with risk of coronary artery disease and age-associated memory impairment. Mice lacking this gene demonstrate impaired memory. This gene is clustered with three other apolipoprotein genes on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]. "
---
> "Q9WUC3-1","NP_001129160.1","lymphocyte antigen 6H isoform b precursor","139",""
12602a12557,12558
> "Q99JY3-1","NP_001230128.1","GTPase IMAP family member 4 isoform c","219","This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. This gene exists within a cluster of other related genes located on mouse chromosome 6. This family member encodes a lymphoid signaling protein that functions to accelerate programmed T-cell death, which appears to correlate with the phosphorylation status of the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]. "
> "Q01887-1","NP_001036072.1","tyrosine-protein kinase RYK isoform 2 precursor","591",""
12603a12560
> "A2AWA9-1","NP_001029132.1","rab GTPase-activating protein 1 isoform b","809",""
12605c12562
< "Q9QYE9-1","NP_038774.1","pleckstrin homology domain-containing family B member 1 isoform a","243",""
---
> "Q91ZP3-1","NP_001123884.1","phosphatidate phosphatase LPIN1 isoform a","891",""
12609,12610c12566
< "Q9ET47-1","NP_997574.2","espin isoform 3","524",""
< "P46737-1","NP_666068.1","lys-63-specific deubiquitinase BRCC36","291",""
---
> "Q80XU3-1","NP_001139276.1","nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform 2","233",""
12612c12568
< "Q3USJ8-1","NP_950177.2","F-BAR and double SH3 domains protein 2 isoform 1","764",""
---
> "Q9Z0P4-1","NP_001155219.1","paralemmin-1 isoform 2","339",""
12616,12617c12572
< "Q8BRT1-1","NP_001273532.1","CLIP-associating protein 2 isoform h","167",""
< "Q8R4P9-1","NP_733780.1","multidrug resistance-associated protein 7 isoform mrp7B","1501","The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]. "
---
> "Q60902-1","NP_001116304.1","epidermal growth factor receptor substrate 15-like 1 isoform b","599",""
12619,12620c12574
< "Q61107-1","NP_061204.3","guanylate-binding protein 4","620",""
< "O70252-1","NP_034573.2","heme oxygenase 2 isoform 1","315",""
---
> "Q8K019-1","NP_001020563.1","bcl-2-associated transcription factor 1 isoform 1","919",""
12621a12576
> "P16563-1","NP_001191000.1","cysteine-rich secretory protein 2 precursor","243",""
12623d12577
< "O55103-1","NP_932165.2","periaxin isoform L","1391",""
12625,12627d12578
< "Q99PL5-1","NP_598329.1","ribosome-binding protein 1 isoform b","701",""
< "O35668-1","NP_817090.1","huntingtin-associated protein 1 isoform B","628","The protein encoded by this gene was first identified as a neuronal protein that binds the HD protein huntingtin. The protein also interacts with kinesin light chain, 14-3-3 proteins, and Abelson helper integration site 1 protein. The protein is involved in intracellular trafficking of vesicles and organelles, and lack of the protein results in neuronal death resembling the hypothalamic degeneration that occurs in Huntington's disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]. "
< "Q8VEM9-1","NP_082186.2","kelch domain-containing protein 3","382",""
12630a12582
> "Q9Z129-1","NP_001191836.1","ATP-dependent DNA helicase Q1 isoform 3","631",""
12632d12583
< "O35678-1","NP_035974.1","monoglyceride lipase isoform b","303","This gene encodes a monoglyceride lipase, which catalyzes the hydrolysis of monoglycerides into fatty acids and glycerol. This enzyme is also thought to hydrolyze the endocannabinoid 2-arachidonoylglycerol. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]. "
12634c12585
< "O54967-1","NP_058068.2","activated CDC42 kinase 1 isoform 1","1055",""
---
> "Q5RJY2-1","NP_001015099.2","G2/M phase-specific E3 ubiquitin-protein ligase isoform 1","716",""
12640a12592
> "O55103-1","NP_062285.1","periaxin isoform S","148",""
12642c12594
< "Q8CH09-1","NP_766343.3","SURP and G-patch domain-containing protein 2","1067",""
---
> "O88559-1","NP_001161960.1","menin isoform a","617",""
12644c12596
< "Q8CHT1-1","NP_063920.2","ephexin-1 isoform 2","620",""
---
> "Q9QW08-1","NP_001153202.1","phosducin","244",""
12647a12600
> "Q8C5W0-1","NP_001035772.1","calmin isoform b","1021",""
12652,12653c12605,12607
< "A2A432-1","NP_082564.3","cullin-4B","970",""
< "Q8BJ56-1","NP_080078.2","patatin-like phospholipase domain-containing protein 2 isoform 2","430",""
---
> "Q8C7M3-1","NP_001103672.1","E3 ubiquitin-protein ligase TRIM9 isoform b","714",""
> "O54751-1","NP_001106801.1","cone-rod homeobox protein isoform 2","323",""
> "Q8C6N3-1","NP_795905.2","synaptotagmin-15 isoform b","389",""
12654a12609
> "Q6VNS1-1","NP_032772.3","NT-3 growth factor receptor isoform a precursor","825",""
12658,12659c12613
< "O55176-3","NP_032879.2","E3 ubiquitin-protein ligase Praja-1 isoform 2","395",""
< "Q8CH72-1","NP_444314.2","E3 ubiquitin-protein ligase TRIM32","655",""
---
> "Q6Q477-1","NP_001161421.1","plasma membrane calcium-transporting ATPase 4 isoform a","1166",""
12660a12615
> "Q8VCQ6-1","NP_001161997.1","phosphatidylcholine:ceramide cholinephosphotransferase 1","419",""
12662a12618,12619
> "D3Z7P3-1","NP_001074550.1","glutaminase kidney isoform, mitochondrial isoform 1","674",""
> "A2ASA8-1","NP_001156999.1","inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 isoform a precursor","547",""
12663a12621
> "Q99PL5-1","NP_077243.2","ribosome-binding protein 1 isoform a","1464",""
12665d12622
< "P09026-1","NP_034588.2","homeobox protein Hox-B3","433",""
12667a12625
> "Q9JJU9-1","NP_001153122.1","beta-crystallin B3","211",""
12669,12670d12626
< "Q9R0Y5-1","NP_067490.1","adenylate kinase isoenzyme 1 isoform 1","210",""
< "A2ASA8-1","NP_001157000.1","inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 isoform a precursor","547",""
12673,12674c12629,12630
< "Q8K4L3-1","NP_694793.1","supervillin isoform a","2170",""
< "O70479-1","NP_033421.3","BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2","316",""
---
> "Q71M36-1","NP_001159745.1","chondroitin sulfate proteoglycan 5 isoform b precursor","566","This gene encodes a chondroitin sulfate proteoglycan. The encoded protein has been termed a 'part-time' proteoglycan, as chondroitin sulfate chains appear to be attached to the protein in the developing but not the adult cerebellum and retina. It is thought that this protein plays roles in dendrite branching and synapse formation. [provided by RefSeq, Oct 2009]. "
> "O54689-1","NP_001177262.1","C-C chemokine receptor type 6 isoform A","367",""
12676d12631
< "Q9JJT9-1","NP_064380.3","phosphorylated adapter RNA export protein isoform 1","385",""
12681c12636,12637
< "Q91XB0-1","NP_035767.4","three-prime repair exonuclease 1","314",""
---
> "O70252-1","NP_001129538.1","heme oxygenase 2 isoform 1","315",""
> "P81067-1","NP_001240751.1","iroquois-class homeodomain protein IRX-3 isoform 1","522",""
12684d12639
< "Q61017-1","NP_075610.1","guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 precursor","69",""
12692a12648
> "Q8C0T5-1","NP_001161455.1","signal-induced proliferation-associated 1-like protein 1 isoform 2","1751",""
12695a12652
> "Q923S6-1","NP_001156952.1","E3 ubiquitin-protein ligase NEURL1 isoform 2","557",""
12700c12657
< "Q80YQ2-1","NP_081623.3","mediator of RNA polymerase II transcription subunit 23 isoform 2","1370",""
---
> "Q61017-1","NP_001033753.2","guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 precursor","69",""
12705a12663
> "Q60865-1","NP_001104759.1","caprin-1 isoform a","707",""
12711,12712d12668
< "P19426-1","NP_613046.2","negative elongation factor E","367",""
< "Q9CY58-1","NP_080090.2","plasminogen activator inhibitor 1 RNA-binding protein isoform 1","407",""
12716,12717d12671
< "Q8CJ53-1","NP_598886.1","cdc42-interacting protein 4 isoform 3","547",""
< "P62983-1","NP_077239.1","ubiquitin-40S ribosomal protein S27a precursor","156",""
12719c12673
< "Q6ZQM0-1","NP_080373.1","E3 ubiquitin-protein ligase rififylin isoform 2","335",""
---
> "P19426-1","NP_001039328.1","negative elongation factor E","367",""
12720a12675
> "P08923-1","NP_976220.2","leukocyte tyrosine kinase receptor isoform D precursor","888","The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Four alternatively spliced transcript variants encoding different isoforms have been described for this gene. These transcripts are expressed in a tissue-specific manner in lymphocytes, brain and neuroblastoma cells, and the encoded isoforms exhibit different subcellular localization. The lymphocyte and brain specific variants initiate translation at non-AUG (CUG) start codons. [provided by RefSeq, Jul 2008]. "
12723d12677
< "P47801-1","NP_034258.1","epithelial membrane protein 1 isoform a","160",""
12726a12681
> "Q99LJ0-1","NP_001156804.1","CTTNBP2 N-terminal-like protein","638",""
12736c12691
< "Q9ESF1-1","NP_114081.2","otoferlin isoform 2","1997",""
---
> "P58283-1","NP_542128.2","E3 ubiquitin-protein ligase RNF216 isoform A","853",""
12747a12703,12704
> "Q91YD6-1","NP_001158039.1","villin-like protein isoform 1","859",""
> "Q62132-1","NP_001155309.1","receptor-type tyrosine-protein phosphatase R isoform b","549",""
12756d12712
< "O35711-1","NP_032931.2","liprin-beta-2 isoform 1","882",""
12758c12714
< "P51829-1","NP_031432.2","adenylate cyclase type 7","1099",""
---
> "Q3V3R1-1","NP_001164256.1","monofunctional C1-tetrahydrofolate synthase, mitochondrial precursor","977",""
12764d12719
< "P27546-1","NP_032659.2","microtubule-associated protein 4 isoform 2","1125",""
12767,12768d12721
< "P98195-1","NP_056620.2","probable phospholipid-transporting ATPase IIB isoform 2","1135",""
< "O54751-1","NP_031796.1","cone-rod homeobox protein isoform 1","299",""
12775,12777d12727
< "Q9DBA9-1","NP_032212.3","general transcription factor IIH subunit 1 isoform 2","547",""
< "P12849-1","NP_032949.3","cAMP-dependent protein kinase type I-beta regulatory subunit isoform a","381",""
< "P97443-1","NP_033892.2","histone-lysine N-methyltransferase Smyd1 isoform 2","477",""
12785a12736
> "Q8VH31-1","NP_001138485.1","ret finger protein-like 4A","287",""
12791a12743
> "Q8VDP3-1","NP_001157905.1","[F-actin]-monooxygenase MICAL1 isoform 2","975",""
12794d12745
< "Q9QWW1-1","NP_036113.1","homer protein homolog 2 isoform 1","354",""
12798a12750,12751
> "Q8BYH0-1","NP_001001796.1","dorsal root ganglia homeobox protein isoform 2","220",""
> "Q9QXT8-1","NP_001104801.1","calsenilin isoform b precursor","230",""
12801a12755,12756
> "Q99J99-1","NP_001155964.1","3-mercaptopyruvate sulfurtransferase","297",""
> "Q8CGF7-1","NP_001034563.1","transcription elongation regulator 1 isoform 1","1100",""
12803,12805c12758,12760
< "D3Z7P3-1","NP_001106854.1","glutaminase kidney isoform, mitochondrial isoform 2","603",""
< "O54784-1","NP_031854.1","death-associated protein kinase 3 isoform b","448",""
< "Q8C6B2-1","NP_598396.2","rhotekin isoform b","551",""
---
> "Q9D032-1","NP_076161.2","single-stranded DNA-binding protein 3 isoform a","388","This gene encodes a member of the Ssdp (sequence-specific single-stranded DNA binding protein) family of proteins. The encoded protein binds specifically to single-stranded pyrimidine-rich DNA elements. The encoded protein has been shown to be important for head development and may play a role in the differentiation of spinal interneurons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
> "O54693-1","NP_001171408.1","ectodysplasin-A isoform 2","389",""
> "Q9ESE1-1","NP_001071155.1","lipopolysaccharide-responsive and beige-like anchor protein isoform gamma","2577",""
12809a12765
> "Q8CHT1-1","NP_001104784.1","ephexin-1 isoform 1","710",""
12811a12768
> "Q3UHJ0-1","NP_001035195.1","AP2 associated kinase 1 isoform 1","959",""
12815d12771
< "Q8CGN5-1","NP_783571.2","perilipin-1","517",""
12818,12819d12773
< "Q9JLV2-1","NP_062802.2","short transient receptor potential channel 4-associated protein isoform 2","789",""
< "P60762-1","NP_077751.1","mortality factor 4-like protein 1 isoform b","323",""
12822a12777
> "Q9QYY1-1","NP_001139559.1","interleukin-36 receptor antagonist protein","156",""
12824a12780
> "Q91ZK4-1","NP_001020738.1","diencephalon/mesencephalon homeobox protein 1 isoform b","376",""
12827d12782
< "Q71M36-1","NP_038912.3","chondroitin sulfate proteoglycan 5 isoform a precursor","539","This gene encodes a chondroitin sulfate proteoglycan. The encoded protein has been termed a 'part-time' proteoglycan, as chondroitin sulfate chains appear to be attached to the protein in the developing but not the adult cerebellum and retina. It is thought that this protein plays roles in dendrite branching and synapse formation. [provided by RefSeq, Oct 2009]. "
12829a12785
> "Q8VEM9-1","NP_001157201.2","kelch domain-containing protein 3","382",""
12830a12787
> "P09026-1","NP_001073338.1","homeobox protein Hox-B3","433",""
12841,12843d12797
< "Q8VDU5-1","NP_598502.2","SNF-related serine/threonine-protein kinase","748",""
< "O88559-1","NP_032609.1","menin isoform b","611",""
< "Q3U8K7-1","NP_659120.3","histone-lysine N-methyltransferase KMT5B isoform b","860",""
12845c12799
< "P70352-1","NP_031517.2","ecto-ADP-ribosyltransferase 5 precursor","309",""
---
> "Q9DBF1-1","NP_001120810.1","alpha-aminoadipic semialdehyde dehydrogenase isoform b","511",""
12854c12808
< "Q8C7M3-1","NP_444397.2","E3 ubiquitin-protein ligase TRIM9 isoform a","788",""
---
> "P33175-1","NP_001034089.1","kinesin heavy chain isoform 5A","1027",""
12857c12811
< "Q9WUT7-1","NP_034043.1","C-C chemokine receptor type 9","369",""
---
> "Q9R0Y5-1","NP_001185719.1","adenylate kinase isoenzyme 1 isoform 2","194",""
12864,12865d12817
< "Q9WV69-1","NP_038542.1","dematin isoform 2","383",""
< "Q9Z129-1","NP_075529.2","ATP-dependent DNA helicase Q1 isoform 1","648",""
12869d12820
< "Q8BHS8-1","NP_848880.2","syntabulin isoform c","665",""
12875,12876d12825
< "O89112-1","NP_067270.1","glutathione S-transferase LANCL1","399",""
< "Q62159-1","NP_031510.2","rho-related GTP-binding protein RhoC precursor","193",""
12879d12827
< "Q6P7F1-1","NP_660125.2","MAGUK p55 subfamily member 4 isoform 2","635",""
12881a12830,12831
> "O08665-1","NP_001230001.1","semaphorin-3A precursor","772",""
> "Q32MG2-1","NP_001157611.1","spermatid-associated protein isoform 1","446",""
12888a12839,12840
> "Q692V3-1","NP_001003910.2","tetratricopeptide repeat protein 41 isoform 3","1318",""
> "O35678-1","NP_001159721.1","monoglyceride lipase isoform c","258","This gene encodes a monoglyceride lipase, which catalyzes the hydrolysis of monoglycerides into fatty acids and glycerol. This enzyme is also thought to hydrolyze the endocannabinoid 2-arachidonoylglycerol. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]. "
12890d12841
< "Q60952-1","NP_796191.2","centrosome-associated protein CEP250 isoform 1","2414",""
12893,12894c12844
< "Q80XG9-1","NP_848846.3","leucine-rich repeat transmembrane neuronal protein 4 isoform 1 precursor","518",""
< "O35682-1","NP_058665.2","myeloid-associated differentiation marker","320",""
---
> "P60762-1","NP_001034236.1","mortality factor 4-like protein 1 isoform a","362",""
12896d12845
< "O88520-1","NP_062632.2","leucine-rich repeat protein SHOC-2","582",""
12897a12847
> "Q9ESN9-1","NP_001156919.1","C-Jun-amino-terminal kinase-interacting protein 3 isoform b","1336",""
12902d12851
< "Q9ERD8-1","NP_071716.3","gamma-parvin isoform 2","331",""
12904c12853
< "O70318-1","NP_038539.2","band 4.1-like protein 2 isoform 1","988",""
---
> "P51791-1","NP_031737.1","H(+)/Cl(-) exchange transporter 3 isoform a","760",""
12906a12856
> "Q8CIV7-1","NP_081200.2","transcription factor Ovo-like 2 isoform A","274",""
12914d12863
< "P97822-1","NP_075699.3","acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 1","260",""
12916a12866
> "Q6ZQM0-1","NP_001158042.1","E3 ubiquitin-protein ligase rififylin isoform 4","377",""
12917a12868
> "Q9QWT9-1","NP_001182227.1","kinesin-like protein KIFC1","674",""
12920,12921d12870
< "Q810U4-1","NP_795904.3","neuronal cell adhesion molecule isoform 1 precursor","1256",""
< "Q6DIC0-1","NP_035546.2","probable global transcription activator SNF2L2 isoform 1","1583",""
12923a12873
> "P48025-1","NP_001185906.1","tyrosine-protein kinase SYK","629",""
12925,12928c12875,12878
< "Q99JP6-1","NP_036114.2","homer protein homolog 3 isoform 2","356",""
< "Q9QXJ1-1","NP_033815.1","amyloid-beta A4 precursor protein-binding family B member 1 isoform 2","708",""
< "Q69ZW3-1","NP_694718.4","EH domain-binding protein 1 isoform 2","1206",""
< "Q8R317-1","NP_689420.1","ubiquilin-1 isoform 2","554",""
---
> "Q9R0B9-1","NP_001136388.1","procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 1 precursor","758",""
> "Q8CIE4-1","NP_001157047.1","protein mono-ADP-ribosyltransferase PARP10","960",""
> "P49766-1","NP_001172093.1","vascular endothelial growth factor B isoform Vegf-b167 precursor","188",""
> "Q05AH6-1","NP_001028311.2","spindlin interactor and repressor of chromatin-binding protein isoform 1","381",""
12930,12933c12880,12885
< "Q6KAU7-1","NP_620091.2","pleckstrin homology domain-containing family G member 2 isoform a","1341",""
< "Q9WTI7-1","NP_032685.1","unconventional myosin-Ic isoform b","1028","This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The protein functions in intracellular vesicle transport to the plasma membrane. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. "
< "Q9R0B9-1","NP_036091.2","procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 2 precursor","737",""
< "Q91YD6-1","NP_035830.2","villin-like protein isoform 2","775",""
---
> "Q8BY87-1","NP_598519.2","ubiquitin carboxyl-terminal hydrolase 47 isoform 2","1356",""
> "O54784-1","NP_001177402.1","death-associated protein kinase 3 isoform b","448",""
> "Q9CR84-1","NP_001154891.1","ATP synthase F(0) complex subunit C1, mitochondrial","136",""
> "O54830-1","NP_001157530.1","prolactin-7A1 isoform 1 precursor","266",""
> "O70318-1","NP_001186194.1","band 4.1-like protein 2 isoform 1","988",""
> "O88520-1","NP_001161977.1","leucine-rich repeat protein SHOC-2","582",""
12938d12889
< "Q7TN58-1","NP_862904.1","transmembrane channel-like protein 8 isoform C","722",""
12941d12891
< "Q9CYZ8-1","NP_077234.2","single-stranded DNA-binding protein 2 isoform 2","361",""
12943,12945c12893,12894
< "Q9ESE1-1","NP_109620.2","lipopolysaccharide-responsive and beige-like anchor protein isoform alpha","2854",""
< "O09053-1","NP_035851.3","Werner syndrome ATP-dependent helicase homolog","1401",""
< "P04627-1","NP_033833.1","serine/threonine-protein kinase A-Raf isoform 1","604",""
---
> "Q80XG9-1","NP_001128215.1","leucine-rich repeat transmembrane neuronal protein 4 isoform 3 precursor","591",""
> "P63034-1","NP_001106171.1","cytohesin-2 isoform 2","399",""
12948c12897
< "P48025-1","NP_035648.2","tyrosine-protein kinase SYK","629",""
---
> "Q80TY0-1","NP_001033789.1","formin-binding protein 1 isoform a","550",""
12951a12901
> "Q9ERD8-1","NP_001155972.1","gamma-parvin isoform 1","384",""
12956a12907
> "B1AUH1-1","NP_001076588.1","receptor-type tyrosine-protein phosphatase U isoform 2 precursor","1446",""
12958,12959c12909
< "P63034-1","NP_035311.1","cytohesin-2 isoform 1","400",""
< "Q920C1-1","NP_112548.2","chordin-like protein 1 isoform 2 precursor","333",""
---
> "Q9WUK6-1","NP_001012330.1","zinc finger and BTB domain-containing protein 18 isoform 1","531",""
12963a12914,12915
> "Q9ES70-1","NP_001153103.1","serine/threonine-protein kinase Nek6","313",""
> "Q6P7F1-1","NP_001158154.1","MAGUK p55 subfamily member 4 isoform 1","654",""
12965d12916
< "Q91V87-1","NP_473412.1","fibroblast growth factor receptor-like 1 isoform 1 precursor","529",""
12968c12919,12920
< "Q9JI70-1","NP_067502.2","McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin isoform 1","570","This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins. Alternatively spliced transcripts encoding distinct isoforms have been found for this gene. [provided by RefSeq, Nov 2013]. "
---
> "Q68FH0-1","NP_080637.1","plakophilin-4 isoform 1","1190",""
> "Q9JKV2-1","NP_001157252.1","serine/threonine-protein kinase ICK","629",""
12971d12922
< "Q9CZY3-1","NP_075719.1","ubiquitin-conjugating enzyme E2 variant 1 isoform 2","147",""
12973d12923
< "Q80TV8-1","NP_083985.2","CLIP-associating protein 1 isoform 3","1460",""
12979a12930
> "O89112-1","NP_001177913.1","glutathione S-transferase LANCL1","399",""
12981d12931
< "Q9JJU9-1","NP_067327.1","beta-crystallin B3","211",""
12984c12934
< "P49766-1","NP_035827.1","vascular endothelial growth factor B isoform Vegf-b186 precursor","207",""
---
> "P17012-1","NP_001037851.1","zinc finger X-chromosomal protein isoform 1","799",""
12987c12937
< "Q60I26-1","NP_666340.3","ALS2 C-terminal-like protein","952",""
---
> "Q9Z2C5-1","NP_001157662.1","myotubularin isoform 1","603",""
12995a12946
> "Q9JLV2-1","NP_001156924.1","short transient receptor potential channel 4-associated protein isoform 1","797",""
12996a12948,12949
> "Q04692-1","NP_001240321.1","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 isoform 2","836",""
> "Q810U4-1","NP_001139503.1","neuronal cell adhesion molecule isoform 2 precursor","1186",""
13002c12955
< "Q61334-1","NP_031556.1","B-cell receptor-associated protein 29","240",""
---
> "Q60I26-1","NP_001139531.1","ALS2 C-terminal-like protein","952",""
13006c12959
< "Q9JMK2-1","NP_038795.3","casein kinase I isoform epsilon isoform a","416","The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]. "
---
> "Q9CYZ8-1","NP_077148.1","single-stranded DNA-binding protein 2 isoform 1","331",""
13009,13010d12961
< "O54951-1","NP_038690.1","semaphorin-6B precursor","886",""
< "Q61699-1","NP_038587.2","heat shock protein 105 kDa isoform 1","858",""
13013d12963
< "Q8CBY1-1","NP_083242.1","protein Smaug homolog 1 isoform 2","623",""
13017a12968,12969
> "O54926-1","NP_001155209.1","apoptosis regulatory protein Siva isoform 2","110",""
> "Q6DIA9-1","NP_001157174.1","F-box only protein 27 isoform 1","280",""
13019d12970
< "Q5XG73-1","NP_083069.1","acyl-CoA-binding domain-containing protein 5 isoform c","473",""
13023,13024c12974,12976
< "Q9WVE8-1","NP_035992.1","protein kinase C and casein kinase substrate in neurons protein 2 isoform 1","486",""
< "Q3U0M1-1","NP_850993.2","trafficking protein particle complex subunit 9 isoform 2","1139",""
---
> "Q8CH72-1","NP_001155254.1","E3 ubiquitin-protein ligase TRIM32","655",""
> "Q60520-2","NP_001103820.1","paired amphipathic helix protein Sin3a isoform 2","1277",""
> "Q69ZW3-1","NP_001239444.1","EH domain-binding protein 1 isoform 1","1231",""
13026d12977
< "Q80TY0-1","NP_062279.1","formin-binding protein 1 isoform b","338",""
13030,13032c12981
< "P61793-1","NP_766577.1","lysophosphatidic acid receptor 1 isoform 1","364",""
< "Q61481-4","NP_058024.2","calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2","545",""
< "P35292-1","NP_033024.1","ras-related protein Rab-17","214",""
---
> "Q8K2F0-1","NP_001107045.1","bromodomain-containing protein 3 isoform 2","726",""
13039d12987
< "Q8C0T5-1","NP_766167.2","signal-induced proliferation-associated 1-like protein 1 isoform 1","1782",""
13041d12988
< "O35409-1","NP_058050.3","glutamate carboxypeptidase 2 isoform 1","752",""
13046d12992
< "Q99J99-1","NP_619611.3","3-mercaptopyruvate sulfurtransferase","297",""
13051d12996
< "P24721-1","NP_031519.1","asialoglycoprotein receptor 2 isoform a","301","This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Sep 2015]. "
13054a13000
> "Q8C636-1","NP_081859.1","spermatogenesis-associated protein 16 isoform 1","534",""
13056d13001
< "P51791-1","NP_776298.1","H(+)/Cl(-) exchange transporter 3 isoform b","818",""
13057a13003
> "Q3U8K7-1","NP_001161356.1","histone-lysine N-methyltransferase KMT5B isoform d","327",""
13059d13004
< "Q8K2F0-1","NP_075825.3","bromodomain-containing protein 3 isoform 2","726",""
13063c13008
< "Q9QZS8-1","NP_038809.1","SH2 domain-containing protein 3C isoform 1","854",""
---
> "Q9QWW1-1","NP_001157558.1","homer protein homolog 2 isoform 2","343",""
13067c13012
< "Q5UKY4-1","NP_083294.2","cell surface glycoprotein CD200 receptor 3 isoform 3 precursor","275",""
---
> "Q04859-1","NP_001139274.1","serine/threonine-protein kinase MAK isoform 3","550",""
13069,13071c13014
< "P31809-1","NP_001034275.1","carcinoembryonic antigen-related cell adhesion molecule 1 isoform 2 precursor","458",""
< "Q9QYS9-1","NP_068681.1","protein quaking isoform 3","325",""
< "Q9Z1T6-2","NP_035216.2","1-phosphatidylinositol 3-phosphate 5-kinase isoform 2","2052",""
---
> "Q6NZN1-1","NP_001074683.1","peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 1","1644",""
13077,13079d13019
< "Q9QW08-1","NP_077778.1","phosducin","244",""
< "Q60865-1","NP_058019.2","caprin-1 isoform a","707",""
< "O88697-1","NP_035624.3","serine/threonine-protein kinase 16","305",""
13083,13084d13022
< "Q9JMH6-1","NP_056577.2","thioredoxin reductase 1, cytoplasmic isoform 1","499","The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms. [provided by RefSeq, May 2017]. "
< "Q9WUK6-1","NP_038943.3","zinc finger and BTB domain-containing protein 18 isoform 2","522",""
13089c13027
< "Q922D4-1","NP_083732.1","serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 2","844",""
---
> "Q9WVE8-1","NP_001152981.1","protein kinase C and casein kinase substrate in neurons protein 2 isoform 1","486",""
13091d13028
< "A2AH22-1","NP_766257.3","activating molecule in BECN1-regulated autophagy protein 1 isoform 1","1300",""
13102a13040
> "Q91XB0-1","NP_001012236.1","three-prime repair exonuclease 1","314",""
13105a13044
> "Q8CH09-1","NP_001161762.1","SURP and G-patch domain-containing protein 2","1067",""
13115a13055,13056
> "P04627-1","NP_001153117.1","serine/threonine-protein kinase A-Raf isoform 2","186",""
> "P32115-1","NP_001153397.1","paired box protein Pax-4 isoform 2","336",""
13118d13058
< "Q9D0M5-1","NP_080832.1","dynein light chain 2, cytoplasmic","89",""
13120c13060
< "Q05AH6-1","NP_001161303.1","spindlin interactor and repressor of chromatin-binding protein isoform 2","315",""
---
> "Q9D0M5-1","NP_001161943.1","dynein light chain 2, cytoplasmic","89",""
13123a13064
> "Q99JP6-1","NP_001139625.1","homer protein homolog 3 isoform 1","359",""
13127,13128d13067
< "Q692V3-1","NP_001003939.2","tetratricopeptide repeat protein 41 isoform 1","409",""
< "Q7TPQ3-1","NP_766525.3","E3 ubiquitin-protein ligase SHPRH isoform b","1616",""
13130a13070
> "Q7TN58-1","NP_001182019.1","transmembrane channel-like protein 8 isoform D","722",""
13132a13073
> "Q8CGN5-1","NP_001106942.1","perilipin-1","517",""
13134a13076
> "Q922D4-1","NP_001157631.1","serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 3","827",""
13138d13079
< "Q8BH65-1","NP_666081.1","protein DENND6A isoform b","559",""
13141a13083
> "Q61712-1","NP_001177746.1","dnaJ homolog subfamily C member 1 precursor","552",""
13143d13084
< "Q62132-1","NP_035347.1","receptor-type tyrosine-protein phosphatase R isoform a precursor","656",""
13152c13093
< "O09198-1","NP_034892.1","myelin and lymphocyte protein isoform 1","153","This gene encodes a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The encoded protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]. "
---
> "Q9D2M8-1","NP_001152823.1","ubiquitin-conjugating enzyme E2 variant 2 isoform 2","103",""
13154,13155c13095
< "Q09143-1","NP_031539.3","high affinity cationic amino acid transporter 1","622",""
< "P70429-1","NP_031991.3","ena/VASP-like protein isoform 2","393",""
---
> "A2AH22-1","NP_001074223.1","activating molecule in BECN1-regulated autophagy protein 1 isoform 2","1209",""
13159,13160d13098
< "Q8CIE4-1","NP_001157048.1","protein mono-ADP-ribosyltransferase PARP10","960",""
< "Q99LJ0-1","NP_084525.1","CTTNBP2 N-terminal-like protein","638",""
13162a13101,13102
> "Q9Z2Q2-1","NP_001161690.1","lysine-rich nucleolar protein 1 isoform 2","370",""
> "Q922K9-1","NP_001153016.1","tyrosine-protein kinase FRK","512",""
13165d13104
< "Q5RJY2-1","NP_001161436.1","G2/M phase-specific E3 ubiquitin-protein ligase isoform 3","622",""
13181,13182d13119
< "Q6DIA9-1","NP_997121.1","F-box only protein 27 isoform 2","279",""
< "Q8VDP3-1","NP_612188.1","[F-actin]-monooxygenase MICAL1 isoform 1","1048",""
13186a13124,13125
> "O70479-1","NP_001152864.1","BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2","316",""
> "O35912-1","NP_001139818.1","epithelial membrane protein 3","163",""
13190c13129
< "Q8C5L3-1","NP_082358.2","CCR4-NOT transcription complex subunit 2 isoform b","499",""
---
> "P63011-1","NP_001159871.1","ras-related protein Rab-3A","220",""
13194d13132
< "O54830-1","NP_032956.1","prolactin-7A1 isoform 2 precursor","265",""
13198c13136
< "O54926-1","NP_038957.2","apoptosis regulatory protein Siva isoform 1","175",""
---
> "P62983-1","NP_001029037.1","ubiquitin-40S ribosomal protein S27a precursor","156",""
13201d13138
< "P98156-1","NP_038731.2","very low-density lipoprotein receptor isoform a precursor","873",""
13205d13141
< "Q8BY87-1","NP_796223.2","ubiquitin carboxyl-terminal hydrolase 47 isoform 1","1376",""
13210d13145
< "Q8VH31-1","NP_620404.1","ret finger protein-like 4A","287",""
13211a13147
> "O35711-1","NP_001157029.1","liprin-beta-2 isoform 2","904",""
13217d13152
< "Q9D032-1","NP_940840.1","single-stranded DNA-binding protein 3 isoform b","361","This gene encodes a member of the Ssdp (sequence-specific single-stranded DNA binding protein) family of proteins. The encoded protein binds specifically to single-stranded pyrimidine-rich DNA elements. The encoded protein has been shown to be important for head development and may play a role in the differentiation of spinal interneurons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
13218a13154
> "Q9WV02-1","NP_001160095.1","RNA-binding motif protein, X chromosome","391",""
13222a13159
> "Q9WTI7-1","NP_001074243.1","unconventional myosin-Ic isoform b","1028","This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The protein functions in intracellular vesicle transport to the plasma membrane. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. "
13225d13161
< "Q9ESN9-1","NP_038959.2","C-Jun-amino-terminal kinase-interacting protein 3 isoform a","1337",""
13227c13163
< "A1A546-1","NP_082113.2","intestine-specific homeobox isoform 2","240",""
---
> "Q8BJ56-1","NP_001157161.1","patatin-like phospholipase domain-containing protein 2 isoform 1","486",""
13231d13166
< "P08923-1","NP_996825.2","leukocyte tyrosine kinase receptor isoform C precursor","827","The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Four alternatively spliced transcript variants encoding different isoforms have been described for this gene. These transcripts are expressed in a tissue-specific manner in lymphocytes, brain and neuroblastoma cells, and the encoded isoforms exhibit different subcellular localization. The lymphocyte and brain specific variants initiate translation at non-AUG (CUG) start codons. [provided by RefSeq, Jul 2008]. "
13235a13171
> "Q9JI70-1","NP_001135418.1","McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin isoform 1","570","This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins. Alternatively spliced transcripts encoding distinct isoforms have been found for this gene. [provided by RefSeq, Nov 2013]. "
13239c13175,13176
< "Q8C5D8-1","NP_032628.3","E3 SUMO-protein ligase PIAS2 isoform 1","621",""
---
> "P27546-1","NP_001192259.1","microtubule-associated protein 4 isoform 1","1125",""
> "Q3U0M1-1","NP_001158113.1","trafficking protein particle complex subunit 9 isoform 3","940",""
13241a13179
> "O35668-1","NP_034534.1","huntingtin-associated protein 1 isoform A","598","The protein encoded by this gene was first identified as a neuronal protein that binds the HD protein huntingtin. The protein also interacts with kinesin light chain, 14-3-3 proteins, and Abelson helper integration site 1 protein. The protein is involved in intracellular trafficking of vesicles and organelles, and lack of the protein results in neuronal death resembling the hypothalamic degeneration that occurs in Huntington's disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]. "
13243a13182
> "A2AQ25-1","NP_001074475.1","sickle tail protein isoform c","1997",""
13248a13188
> "Q9CYB0-1","NP_001157692.1","E3 ubiquitin-protein ligase TRIM13","407",""
13250,13251c13190
< "Q91ZK4-1","NP_570935.3","diencephalon/mesencephalon homeobox protein 1 isoform a","381",""
< "O70458-1","NP_035149.2","oncostatin-M-specific receptor subunit beta isoform 1 precursor","971",""
---
> "Q7TPQ3-1","NP_001071175.1","E3 ubiquitin-protein ligase SHPRH isoform a","1674",""
13256,13257d13194
< "P32115-1","NP_035168.1","paired box protein Pax-4 isoform 1","349",""
< "Q99KV1-1","NP_080676.3","dnaJ homolog subfamily B member 11 precursor","358",""
13258a13196,13198
> "Q99MR6-1","NP_001103379.1","serrate RNA effector molecule homolog isoform 2","868",""
> "Q99KV1-1","NP_001177733.1","dnaJ homolog subfamily B member 11 precursor","358",""
> "P56404-1","NP_001102515.1","aquaporin-8 isoform 2","260",""
13259a13200
> "Q32NZ6-1","NP_001098722.1","transmembrane channel-like protein 5 isoform a","967",""
13267a13209
> "Q9Z0S6-1","NP_001153568.1","claudin-10 isoform a_i1","210","This intronless gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight unction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Six alternatively spliced transcript variants have been identified, which encode different isoforms with distinct electric charge of the first extracellular loop and with or without the fourth transmembrane region. These isoforms exhibit distinct localization and function in paracellular anion or cation permeability. [provided by RefSeq, Aug 2010]. "
13271d13212
< "Q3UHJ0-1","NP_808430.2","AP2 associated kinase 1 isoform 2","878",""
13281d13221
< "Q9JKV2-1","NP_064371.2","serine/threonine-protein kinase ICK","629",""
13283d13222
< "P33175-1","NP_032473.2","kinesin heavy chain isoform 5A","1027",""
13287d13225
< "Q32MG2-1","NP_080733.2","spermatid-associated protein isoform 2","410",""
13289,13290c13227
< "Q68FH0-1","NP_780673.2","plakophilin-4 isoform 2","1147",""
< "Q3TRM4-1","NP_056616.2","neuropathy target esterase isoform 2","1327",""
---
> "P97443-1","NP_001153599.1","histone-lysine N-methyltransferase Smyd1 isoform 1","490",""
13291a13229
> "Q9ESF1-1","NP_001093865.1","otoferlin isoform 1","1992",""
13293a13232
> "Q8BTM9-1","NP_001167626.1","RAS guanyl-releasing protein 4 isoform 1","678",""
13295d13233
< "Q8BTM9-1","NP_660131.2","RAS guanyl-releasing protein 4 isoform 2","673",""
13298,13300d13235
< "Q9CWR0-1","NP_082303.2","rho guanine nucleotide exchange factor 25 isoform 1","618",""
< "Q8CIV7-1","NP_694455.2","transcription factor Ovo-like 2 isoform B","241",""
< "Q8K019-1","NP_722482.1","bcl-2-associated transcription factor 1 isoform 2","917",""
13303d13237
< "O70491-1","NP_033317.2","receptor for retinol uptake STRA6","670",""
13307d13240
< "Q8C6N3-1","NP_852682.1","synaptotagmin-15 isoform a","418",""
13310a13244
> "P70429-1","NP_001156866.1","ena/VASP-like protein isoform 1","414",""
13317c13251
< "B1AUH1-1","NP_035344.2","receptor-type tyrosine-protein phosphatase U isoform 1 precursor","1436",""
---
> "Q9WUT7-1","NP_001160097.1","C-C chemokine receptor type 9","369",""
13319a13254
> "Q99L90-1","NP_001157628.1","microspherule protein 1 isoform 2","449",""
13322d13256
< "P63011-1","NP_033027.1","ras-related protein Rab-3A","220",""
13324d13257
< "Q99MR6-1","NP_113582.1","serrate RNA effector molecule homolog isoform 1","875",""
13328,13329d13260
< "Q9D6L8-1","NP_081650.2","peptidyl-prolyl cis-trans isomerase-like 3 isoform 2","120",""
< "P17012-1","NP_035898.2","zinc finger X-chromosomal protein isoform 1","799",""
13333d13263
< "A2AQ25-1","NP_835160.2","sickle tail protein isoform a","1352",""
13335a13266
> "Q61210-1","NP_001123622.1","rho guanine nucleotide exchange factor 1 isoform a","979",""
13337c13268
< "Q3UYC0-1","NP_795893.2","protein phosphatase 1H isoform 2","469",""
---
> "Q9CY58-1","NP_001107037.1","plasminogen activator inhibitor 1 RNA-binding protein isoform 3","392",""
13339d13269
< "P58283-1","NP_996993.1","E3 ubiquitin-protein ligase RNF216 isoform B","910",""
13344d13273
< "O54693-1","NP_034229.1","ectodysplasin-A isoform 1","391",""
13346d13274
< "Q00724-1","NP_035385.1","retinol-binding protein 4 isoform 2 precursor","201",""
13349d13276
< "P41731-1","NP_031679.1","CD63 antigen","238",""
13351d13277
< "Q60520-2","NP_035508.2","paired amphipathic helix protein Sin3a isoform 1","1274",""
13353a13280
> "Q6KAU7-1","NP_001077381.1","pleckstrin homology domain-containing family G member 2 isoform b","1340",""
13357,13359d13283
< "Q91Z31-1","NP_062423.1","polypyrimidine tract-binding protein 2 isoform 1","532",""
< "Q99L90-1","NP_058046.2","microspherule protein 1 isoform 1","462",""
< "Q04859-1","NP_032573.2","serine/threonine-protein kinase MAK isoform 2","622",""
13363c13287
< "Q8C9H6-1","NP_796178.2","striatin-interacting proteins 2 isoform a","844",""
---
> "Q5UKY4-1","NP_001121604.1","cell surface glycoprotein CD200 receptor 3 isoform 1 precursor","278",""
13368d13291
< "Q9CYB0-1","NP_075722.1","E3 ubiquitin-protein ligase TRIM13","407",""
13373c13296
< "Q922K9-1","NP_034367.2","tyrosine-protein kinase FRK","512",""
---
> "Q5XG73-1","NP_001095906.1","acyl-CoA-binding domain-containing protein 5 isoform d","472",""
13374a13298,13299
> "P42208-1","NP_001153189.1","septin-2 isoform a","361",""
> "Q920C1-1","NP_001107857.1","chordin-like protein 1 isoform 1 precursor","447",""
13377a13303
> "Q00731-1","NP_001020421.2","vascular endothelial growth factor A isoform 1","392","This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.[provided by RefSeq, Nov 2015]. "
13382a13309
> "Q9JMH6-1","NP_001035978.1","thioredoxin reductase 1, cytoplasmic isoform 1","499","The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms. [provided by RefSeq, May 2017]. "
13385c13312
< "Q61712-1","NP_031895.1","dnaJ homolog subfamily C member 1 precursor","552",""
---
> "Q00724-1","NP_001152959.1","retinol-binding protein 4 isoform 1","245",""
13391d13317
< "Q9CR84-1","NP_031532.2","ATP synthase F(0) complex subunit C1, mitochondrial","136",""
13394a13321
> "O70491-1","NP_001155947.1","receptor for retinol uptake STRA6","670",""
13396a13324,13325
> "Q9CWR0-1","NP_001159885.1","rho guanine nucleotide exchange factor 25 isoform 2","609",""
> "Q8C6B2-1","NP_001129699.1","rhotekin isoform a","564",""
13399d13327
< "Q61210-1","NP_032514.1","rho guanine nucleotide exchange factor 1 isoform d","919",""
13403a13332,13333
> "Q8C5L3-1","NP_001032935.2","CCR4-NOT transcription complex subunit 2 isoform a","540",""
> "O09053-1","NP_001116294.1","Werner syndrome ATP-dependent helicase homolog","1401",""
13410,13412c13340
< "Q9DBF1-1","NP_613066.2","alpha-aminoadipic semialdehyde dehydrogenase isoform a","539",""
< "P42208-1","NP_035021.1","septin-2 isoform a","361",""
< "Q8C636-1","NP_083426.1","spermatogenesis-associated protein 16 isoform 2","571",""
---
> "Q8C5D8-1","NP_001157639.1","E3 SUMO-protein ligase PIAS2 isoform 2","580",""
13414c13342
< "P86793-1","NP_075539.1","C-C motif chemokine 21c precursor","133",""
---
> "Q61301-1","NP_001103234.1","catenin alpha-2 isoform 2","953",""
13416d13343
< "O08665-1","NP_033178.2","semaphorin-3A precursor","772",""
13421,13422c13348
< "Q6VNS1-1","NP_877961.1","NT-3 growth factor receptor isoform b precursor","612",""
< "P16563-1","NP_033446.1","cysteine-rich secretory protein 2 precursor","243",""
---
> "A2A432-1","NP_001103612.1","cullin-4B","970",""
13432c13358
< "Q3V3R1-1","NP_758512.3","monofunctional C1-tetrahydrofolate synthase, mitochondrial precursor","977",""
---
> "Q8BG05-1","NP_444493.1","heterogeneous nuclear ribonucleoprotein A3 isoform c","357",""
13437d13362
< "Q61301-1","NP_663785.2","catenin alpha-2 isoform 1","905",""
13444d13368
< "Q6Q477-1","NP_998781.1","plasma membrane calcium-transporting ATPase 4 isoform b","1205",""
13448d13371
< "Q8BZS9-1","NP_598702.1","putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform a","751",""
13451d13373
< "Q9Z0S6-1","NP_076367.2","claudin-10 isoform a","229","This intronless gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight unction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Six alternatively spliced transcript variants have been identified, which encode different isoforms with distinct electric charge of the first extracellular loop and with or without the fourth transmembrane region. These isoforms exhibit distinct localization and function in paracellular anion or cation permeability. [provided by RefSeq, Aug 2010]. "
13454d13375
< "Q9D2M8-1","NP_076074.2","ubiquitin-conjugating enzyme E2 variant 2 isoform 1","145",""
13459a13381,13382
> "O54967-1","NP_001103617.1","activated CDC42 kinase 1 isoform 2","1008",""
> "Q60952-1","NP_001123471.1","centrosome-associated protein CEP250 isoform 2","2434",""
13461d13383
< "Q8C0D4-1","NP_083553.2","rho GTPase-activating protein 12 isoform 2","813",""
13463d13384
< "O35912-1","NP_034259.2","epithelial membrane protein 3","163",""
13464a13386
> "Q80YQ2-1","NP_001159888.1","mediator of RNA polymerase II transcription subunit 23 isoform 1","1376",""
13466d13387
< "Q8C5W0-1","NP_444385.2","calmin isoform a","1052",""
13468c13389
< "P56404-1","NP_031500.1","aquaporin-8 isoform 1","261",""
---
> "P41731-1","NP_001036045.1","CD63 antigen","238",""
13471c13392
< "P54310-1","NP_034849.2","hormone-sensitive lipase isoform 1","802",""
---
> "Q8C0D4-1","NP_001034781.1","rho GTPase-activating protein 12 isoform 1","838",""
13472a13394
> "Q8C9H6-1","NP_001032829.1","striatin-interacting proteins 2 isoform b","816",""
13477a13400,13401
> "Q8R317-1","NP_081118.4","ubiquilin-1 isoform 1","582",""
> "O54951-1","NP_001123928.1","semaphorin-6B precursor","886",""
13484a13409
> "Q8CBY1-1","NP_001032298.1","protein Smaug homolog 1 isoform 1","711",""
13490,13491c13415,13416
< "O54689-1","NP_033965.1","C-C chemokine receptor type 6 isoform A","367",""
< "Q32NZ6-1","NP_083206.1","transmembrane channel-like protein 5 isoform b","757",""
---
> "P51829-1","NP_001032812.2","adenylate cyclase type 7","1099",""
> "Q9QZS8-1","NP_001239476.1","SH2 domain-containing protein 3C isoform 2","702",""
13494,13495c13419,13420
< "Q9QYY1-1","NP_062324.2","interleukin-36 receptor antagonist protein","156",""
< "Q923S6-1","NP_067335.4","E3 ubiquitin-protein ligase NEURL1 isoform 1","574",""
---
> "P97822-1","NP_001240687.1","acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 3","137",""
> "P35292-1","NP_001153197.2","ras-related protein Rab-17","214",""
13502d13426
< "Q3UIZ8-1","NP_780650.2","myosin light chain kinase 3 isoform 1","795",""
13506d13429
< "Q9ES70-1","NP_067619.1","serine/threonine-protein kinase Nek6","313",""
13507a13431
> "P98156-1","NP_001154892.1","very low-density lipoprotein receptor isoform b precursor","845",""
13509d13432
< "Q9WV02-1","NP_035382.1","RNA-binding motif protein, X chromosome","391",""
13511a13435
> "Q9QXJ1-1","NP_001240814.1","amyloid-beta A4 precursor protein-binding family B member 1 isoform 1","710",""
13512a13437
> "Q8BHS8-1","NP_001027899.1","syntabulin isoform b","593",""
13514d13438
< "P81067-1","NP_032419.2","iroquois-class homeodomain protein IRX-3 isoform 2","507",""
13515a13440
> "O35682-1","NP_001087233.1","myeloid-associated differentiation marker","320",""
13516a13442
> "Q3UYC0-1","NP_001103688.1","protein phosphatase 1H isoform 1","513",""
13519c13445
< "Q8BG05-1","NP_932758.1","heterogeneous nuclear ribonucleoprotein A3 isoform a","379",""
---
> "Q9JJT9-1","NP_001156461.1","phosphorylated adapter RNA export protein isoform 2","363",""
13520a13447
> "O35409-1","NP_001153178.1","glutamate carboxypeptidase 2 isoform 2","719",""
13523a13451
> "Q91V87-1","NP_001157731.1","fibroblast growth factor receptor-like 1 isoform 2 precursor","438",""
13524a13453
> "P31809-1","NP_001034274.1","carcinoembryonic antigen-related cell adhesion molecule 1 isoform 1 precursor","521",""
13526a13456
> "O09198-1","NP_001164658.1","myelin and lymphocyte protein isoform 2","97","This gene encodes a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The encoded protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]. "
13536a13467
> "P15947-1","NP_001307260.1","kallikrein-1 isoform 2 precursor","213","This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein are unable to generate significant levels of kinins in most tissues, develop cardiovascular abnormalities and exhibit hypercalciuria of renal origin. This gene is located in a cluster of several related kallikrein genes on chromosome 7. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, Feb 2016]. "
13540,13542c13471,13472
< "Q9Z2H2-1","NP_056627.1","regulator of G-protein signaling 6 isoform 2","472","This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP (Dishevelled, Egl-10, and Pleckstrin) and GGL (G-protein gamma like)domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Mice lacking this gene exhibit decreased heart rate. Alternative splicing results in multiple transcript variants, however, the full-length nature of some of these variants is not known. [provided by RefSeq, Sep 2015]. "
< "Q7TQF7-1","NP_778172.1","amphiphysin isoform 1","686",""
< "Q9JJJ7-1","NP_665915.1","protein-serine O-palmitoleoyltransferase porcupine isoform B","456",""
---
> "O09039-1","NP_001293055.1","SH2B adapter protein 3 isoform 1","548","This gene encodes a member of the SH2B family of adapter proteins that play an important role in T cell receptor signaling. This gene is preferentially expressed in hematopoietic stem cells, hematopoietic progenitors, pre and immature B cells, as well as megakaryocytes and mastocytes. In hematopoietic stem cells, the encoded protein is a key regulator of self-renewal, proliferation and apoptosis. Mice lacking the encoded protein exhibit pre and immature B cell expansion in spleen and the bone marrow. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. "
> "P28301-1","NP_001273110.1","protein-lysine 6-oxidase preproprotein","411","This gene encodes a precursor protein that belongs to the lysyl oxidase family of proteins. The secreted proprotein is proteolytically processed to an active mature peptide and a propeptide. This propeptide is thought to function in tumor suppression by inhibiting the Ras signaling pathway. The active enzyme plays a role in cross-linking of collagen and elastin and is essential for development of cardiovascular and respiratory systems, and development of skin and connective tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]. "
13544c13474,13475
< "P17183-1","NP_038537.1","gamma-enolase isoform 1","434",""
---
> "O08992-1","NP_001091697.1","syntenin-1 isoform 1","299",""
> "Q8CBW3-1","NP_001070658.1","abl interactor 1 isoform 1","481",""
13545a13477
> "O70622-1","NP_001020535.1","reticulon-2 isoform C","204",""
13547d13478
< "Q9QYB8-1","NP_038486.2","beta-adducin isoform 1","725","This gene encodes the beta subunit of the adducin family. Adducins, encoded by alpha, beta and gamma genes, are heteromeric proteins that crosslink actin filaments with spectrin at the cytoskeletal membrane. This protein, primarily found in the brain and hematopoietic cells, is regulated by phosphorylation and calmodulin interactions as it promotes spectrin assembly onto actin filaments, bundles actin and caps barbed ends of actin filaments. In mouse, deficiency of this gene can lead to mild hemolytic anemia and impaired synaptic plasticity. Mutations of this gene in mouse serve as a pathophysiological model for hereditary spherocytosis and hereditary elliptocytosis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Dec 2012]. "
13548a13480
> "Q9CWT3-1","NP_001120820.1","sorting nexin-10 isoform a","201",""
13553,13554c13485,13487
< "P63277-4","NP_033796.1","amelogenin, X isoform isoform 2 precursor","196",""
< "P70408-1","NP_033995.1","cadherin-10 preproprotein","788","This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is expressed in the blood-brain barrier and retinal endothelia suggesting a role in the development and maintenance of brain barrier. Alternative splicing results in multiple transcript variants. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 15. [provided by RefSeq, Oct 2015]. "
---
> "P35377-1","NP_001239494.1","nociceptin receptor isoform 1","367","The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]. "
> "P16646-1","NP_001289184.1","peripheral myelin protein 22 isoform 1","160",""
> "P97797-1","NP_001277950.1","tyrosine-protein phosphatase non-receptor type substrate 1 isoform 4 precursor","295",""
13557d13489
< "Q9ESN5-1","NP_851406.1","centromere protein K isoform 2","253",""
13559a13492,13493
> "P50096-1","NP_001289862.1","inosine-5'-monophosphate dehydrogenase 1 isoform 1","572",""
> "Q921C5-1","NP_001034268.1","protein bicaudal D homolog 2 isoform 1","851",""
13560a13495
> "P51432-1","NP_001277278.1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform a","1234",""
13563,13566c13498,13499
< "Q71RI9-1","NP_776124.1","kynurenine--oxoglutarate transaminase 3 isoform 2","420",""
< "Q60592-1","NP_032667.2","microtubule-associated serine/threonine-protein kinase 2 isoform 2","1794",""
< "Q60695-1","NP_058542.2","ral guanine nucleotide dissociation stimulator-like 1 isoform 3","768","This gene encodes a member of the Ras-like (Ral) -selective guanine nucleotide exchange factor (RalGEF) family of small GTPase activators which function both as downstream effectors of activated Ras GTPase and as regulators of certain Ral GTPases in the RalGEF - Ral GTPase signaling pathway. The encoded protein, like other RalGEFs, has an N-terminal ras exchanger motif domain, a catalytic CDC25 homology domain, and a C-terminal ras binding domain that stimulates guanine nucleotide exchange when bound to a Ral GTPase. RalGEF family members bridge the Ras and Ral signaling pathways and are thought to play a role in oncogenic transformation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. "
< "Q61124-1","NP_034037.3","battenin isoform 1","438","This gene encodes a transmembrane protein called battenin that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis genes, cause a number of neurodegenerative diseases collectively known as neuronal ceroid lipofuscinoses, the most common of which is juvenile neuronal ceroid-lipofuscinosis (Batten disease). Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]. "
---
> "Q9WTU3-1","NP_001070967.1","sodium channel protein type 8 subunit alpha isoform 1","1978",""
> "Q64329-1","NP_001276533.1","killer cell lectin-like receptor 3","266",""
13568,13569c13501
< "Q9JK48-1","NP_062337.1","endophilin-B1 isoform 2","365",""
< "P70699-1","NP_032090.3","lysosomal alpha-glucosidase preproprotein","953","This gene encodes a lysosomal acid glucosidase that is involved in the degradation of glycogen. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that cleaves alpha-1-4 and alpha-1-6 glycosidic bonds of glycogen, maltose and intermediate oligosaccharides within the lysosome. Mice lacking the encoded protein exhibit symptoms similar to human Pompe syndrome such as accumulation of glycogen in cardiac and skeletal muscle lysosomes resulting in reduced mobility and strength. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2015]. "
---
> "Q9WUF3-1","NP_001116450.1","CASP8-associated protein 2","1962",""
13572d13503
< "Q8C9B9-1","NP_808520.2","death-inducer obliterator 1 isoform Dido2","1183","This gene encodes a transcription factor involved in apoptosis. The encoded protein functions in cell cycle progression and plays a role in chromosomal stability. This protein regulates the self-renewal of embryonic stem cells. Disruption of this gene in mice causes symptoms similar to myelodysplastic/myeloproliferative diseases in humans. Mice lacking this gene show severely reduced fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]. "
13574,13576d13504
< "P70333-1","NP_063921.1","heterogeneous nuclear ribonucleoprotein H2","449",""
< "Q9DB50-1","NP_081163.2","AP-1 complex subunit sigma-2 isoform 1","160",""
< "P27808-1","NP_034924.3","alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase","447",""
13581c13509
< "Q62048-1","NP_035193.1","astrocytic phosphoprotein PEA-15 isoform 2","130","This gene encodes an adaptor protein that functions as a negative regulator of apoptosis induced by tumor necrosis factor-alpha, tumor necrosis factor-related apoptosis-inducing ligand, and Fas, through its interaction with fas-associated protein with death domain and caspase-8. It also regulates proliferation signaling by relocating the extracellular signal-regulated protein kinases 1 and 2 to the cytosol. The protein encoded by this gene contains an N-terminal death effector domain and a long, flexible C-terminal tail. In humans, the encoded protein is an endogenous substrate for protein kinase C. This protein is overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]. "
---
> "Q99MN9-1","NP_001298078.1","propionyl-CoA carboxylase beta chain, mitochondrial isoform 2 precursor","504",""
13583,13585c13511,13512
< "Q60823-1","NP_031460.1","RAC-beta serine/threonine-protein kinase","481",""
< "Q9QUG3-1","NP_075530.1","prion-like protein doppel precursor","179",""
< "Q08460-1","NP_034740.2","calcium-activated potassium channel subunit alpha-1 isoform 8","1236",""
---
> "Q04735-1","NP_001297385.1","cyclin-dependent kinase 16 isoform 2","461",""
> "Q91X17-1","NP_001265534.1","uromodulin preproprotein","642","This gene encodes a glycoprotein that is the most abundant protein in mammalian urine under physiological conditions. It is synthesized in the kidney as a glycosyl-phosphatidylinositol anchored protein and released into urine as a soluble form by proteolytic cleavage. It is thought to regulate water and salt balance in the thick ascending limb of Henle and to protect against urinary tract infection and calcium oxalate crystal formation. In mouse deficiency of this gene is associated with increased susceptibility to bacterial infections and formation of calcium crystals in kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. "
13587d13513
< "Q5SP85-1","NP_853555.2","coiled-coil domain-containing protein 85A isoform 1","500",""
13590,13591c13516
< "Q8K202-1","NP_073722.1","DNA-directed RNA polymerase I subunit RPA49 isoform b","434",""
< "P97769-1","NP_031735.1","cbp/p300-interacting transactivator 1 isoform a","203",""
---
> "Q9EQN9-1","NP_001263384.1","thiamine transporter 1 isoform b","460",""
13595d13519
< "Q8BWB6-1","NP_083010.2","metalloreductase STEAP2 isoform 1","489",""
13596a13521
> "Q71RI9-1","NP_001280489.1","kynurenine--oxoglutarate transaminase 3 isoform1","455",""
13598,13599d13522
< "Q9WVA3-1","NP_033904.2","mitotic checkpoint protein BUB3","326","This gene encodes a component of the mitotic spindle assembly complex. The encoded protein is involved in the regulation of chromosome segregation during oocyte meiosis. Disruption of this gene results in the accumulation of mitotic errors and is lethal in the embryonic stage. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]. "
< "Q62009-1","NP_056599.1","periostin isoform 1 precursor","811","This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. "
13600a13524
> "Q9CZY3-1","NP_001298075.1","ubiquitin-conjugating enzyme E2 variant 1 isoform 3","105",""
13601a13526
> "P28741-1","NP_001277734.1","kinesin-like protein KIF3A isoform 2","698",""
13603,13604c13528
< "Q7TN22-1","NP_766185.1","thioredoxin domain-containing protein 16 isoform 2 precursor","819",""
< "Q7TSK2-1","NP_067261.2","seizure protein 6 isoform 1 precursor","991",""
---
> "Q9QYB8-1","NP_001258786.1","beta-adducin isoform 1","725","This gene encodes the beta subunit of the adducin family. Adducins, encoded by alpha, beta and gamma genes, are heteromeric proteins that crosslink actin filaments with spectrin at the cytoskeletal membrane. This protein, primarily found in the brain and hematopoietic cells, is regulated by phosphorylation and calmodulin interactions as it promotes spectrin assembly onto actin filaments, bundles actin and caps barbed ends of actin filaments. In mouse, deficiency of this gene can lead to mild hemolytic anemia and impaired synaptic plasticity. Mutations of this gene in mouse serve as a pathophysiological model for hereditary spherocytosis and hereditary elliptocytosis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Dec 2012]. "
13608c13532
< "O35493-1","NP_031740.1","dual specificity protein kinase CLK4 isoform 1","481",""
---
> "Q9JK48-1","NP_001268966.1","endophilin-B1 isoform 1","386",""
13612d13535
< "Q64332-1","NP_038709.1","synapsin-2 isoform IIb","479",""
13614c13537
< "P21550-1","NP_031959.1","beta-enolase","434","This gene encodes one of the three enolase isoenzymes found in vertebrates. Enolase is a dimeric enzyme that converts 2-phosphoglycerate to phosphoenolpyruvate as part of the glycolytic pathway. This isozyme is found in skeletal muscle where it is involved in muscle development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
---
> "Q62141-4","NP_001106719.1","paired amphipathic helix protein Sin3b isoform 2","293",""
13616a13540
> "P54310-1","NP_001034596.1","hormone-sensitive lipase isoform 2","759",""
13618a13543
> "P28661-1","NP_001271321.1","septin-4 isoform 2","379",""
13620,13621c13545
< "Q91WE6-1","NP_653119.1","threonylcarbamoyladenosine tRNA methylthiotransferase isoform 1","578",""
< "Q8CAQ8-1","NP_083949.2","MICOS complex subunit Mic60 isoform 1","757",""
---
> "Q8C796-1","NP_001307483.1","REST corepressor 2","523",""
13623a13548
> "P07147-1","NP_001268943.1","5,6-dihydroxyindole-2-carboxylic acid oxidase precursor","537",""
13625,13626c13550
< "Q6NXW6-1","NP_035363.2","cell cycle checkpoint protein RAD17 isoform 1","688",""
< "Q3ZK22-1","NP_766126.2","vezatin isoform 1","780","This gene encodes a transmembrane protein that is essential for the formation of adherens junctions. It is required for both the pre-implantation morphogenesis of a blastocyst and for the implantation process. The encoded protein is also a component of the ankle-link complex in cochlear hair cells, where it may effect resilience to sound trauma. It is also thought to be involved in dendritic spine morphogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]. "
---
> "Q2VPD4-1","NP_001276608.1","aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 2","569","This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (Per, Arnt, Sim) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian Clock protein, the structurally related Mop4, and hypoxia-inducible factors, such as Hif1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]. "
13630d13553
< "P31750-1","NP_033782.1","RAC-alpha serine/threonine-protein kinase isoform 1","480","This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as glucose metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]. "
13633,13635c13556,13557
< "Q61171-1","NP_035693.3","peroxiredoxin-2","198",""
< "Q9JHL0-1","NP_075253.2","linker for activation of T-cells family member 2 isoform b precursor","191",""
< "P27573-1","NP_032649.2","myelin protein P0 isoform MPZ precursor","248","This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in the orthologous gene in human are associated with myelinating neuropathies. A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2015]. "
---
> "Q8BIF2-1","NP_001020102.2","RNA binding protein fox-1 homolog 3 isoform 3","313",""
> "Q9R0M5-1","NP_001298040.1","thiamin pyrophosphokinase 1 isoform 2","194",""
13637d13558
< "Q810U5-1","NP_080478.2","coiled-coil domain-containing protein 50 isoform 1","305",""
13639d13559
< "Q8R4R6-1","NP_081367.1","nucleoporin NUP35 isoform 1","325",""
13642c13562,13563
< "Q9WUK2-1","NP_291039.1","eukaryotic translation initiation factor 4H isoform 1","248","This gene encodes eukaryotic translation initiation factor 4H (eIF4H) that plays a critical role in the process of protein synthesis. The encoded protein is an RNA-binding protein that, in concert with other translation initiation factors, helps unwind the 5' cap-proximal region of mRNA to prepare it for ribosomal attachment. Mice lacking the encoded protein displayed growth retardation with a significant reduction of body weight, a smaller brain volume and altered brain morphology. Behaviorally, mice lacking the encoded protein exhibit severe impairments of fear-related associative learning and memory formation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]. "
---
> "Q9Z1T6-2","NP_001297553.1","1-phosphatidylinositol 3-phosphate 5-kinase isoform 1","2097",""
> "Q9QYA2-1","NP_001103218.1","mitochondrial import receptor subunit TOM40 homolog","361",""
13644,13646c13565,13567
< "P28741-1","NP_032469.2","kinesin-like protein KIF3A isoform 1","701",""
< "P50096-1","NP_035959.2","inosine-5'-monophosphate dehydrogenase 1 isoform 3","514",""
< "P18894-1","NP_034148.2","D-amino-acid oxidase isoform 1","345",""
---
> "Q8BHY3-1","NP_001229278.1","anoctamin-1 isoform 2","1014",""
> "Q9D6L8-1","NP_001272755.1","peptidyl-prolyl cis-trans isomerase-like 3 isoform 1","161",""
> "Q8BZS9-1","NP_001272959.1","putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform a","751",""
13647a13569,13570
> "P70699-1","NP_001152796.1","lysosomal alpha-glucosidase preproprotein","953","This gene encodes a lysosomal acid glucosidase that is involved in the degradation of glycogen. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that cleaves alpha-1-4 and alpha-1-6 glycosidic bonds of glycogen, maltose and intermediate oligosaccharides within the lysosome. Mice lacking the encoded protein exhibit symptoms similar to human Pompe syndrome such as accumulation of glycogen in cardiac and skeletal muscle lysosomes resulting in reduced mobility and strength. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2015]. "
> "Q9QWZ1-1","NP_001276376.1","cell cycle checkpoint protein RAD1 isoform 1","280",""
13648a13572
> "P97872-1","NP_001155235.1","dimethylaniline monooxygenase [N-oxide-forming] 5 isoform 1","533",""
13649a13574
> "Q8K202-1","NP_001272729.1","DNA-directed RNA polymerase I subunit RPA49 isoform a","482",""
13652c13577
< "Q61955-1","NP_032966.1","kallikrein-8 preproprotein","260","This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein exhibit impaired long-term potentiation and increased anxiety, as well as a hyperkeratosis phenotype. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]. "
---
> "O88346-1","NP_001264832.1","troponin T, slow skeletal muscle isoform 1","262","This gene encodes the slow skeletal tropomyosin-binding subunit of the troponin complex and plays an essential role in the regulation of striated muscle contraction. In humans, mutations in this gene are associated with nemaline myopathy type 5. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]. "
13654c13579
< "Q64387-1","NP_035062.1","prepronociceptin isoform 1 preproprotein","187","This gene encodes the precursor for neuropeptides that have been implicated in a wide range of physiological roles such as transmission and sensitivity to pain, learning, memory, anxiety and depression, in the central nervous system. The encoded protein is a precursor that is proteolytically processed to generate multiple biologically active peptides including nociceptin and nocistatin which have opposite functions in pain transmission. Mice lacking the encoded protein display increased anxiety, elevated basal pain threshold and impaired adaptation to repeated stress. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]. "
---
> "P60904-1","NP_001258513.1","dnaJ homolog subfamily C member 5","198",""
13657,13658c13582,13585
< "Q921C5-1","NP_084067.1","protein bicaudal D homolog 2 isoform 2","820",""
< "P12025-1","NP_034914.1","midkine isoform a precursor","140","This gene encodes a secreted growth factor that belongs to the pleiotrophin/midkine heparin-binding protein family and functions in a variety of biological processes. The encoded cytokine promotes the growth, differentiation, survival and migration of several target cells including leucocytes involved in inflammation. This protein plays a role in the formation of scar tissue and intraperitoneal adhesions, and promotes neurite outgrowth and neuron survival. The protein encoded by this gene is associated with obesity and inhibition of insulin signaling in fat cells. A pseudogene of this gene is present on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]. "
---
> "Q9EPL2-1","NP_001277918.1","calsyntenin-1 isoform 2 precursor","969",""
> "P31750-1","NP_001159366.1","RAC-alpha serine/threonine-protein kinase isoform 2","488","This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as glucose metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]. "
> "Q9Z186-1","NP_001276785.1","glucose-6-phosphatase 2 isoform 2","239","This gene encodes an enzyme that belongs to the glucose-6-phosphatase catalytic subunit family. Members of this family catalyze the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, to release glucose into the bloodstream. The family member encoded by this gene is found specifically in pancreatic islets but has not been shown to have phosphotransferase or phosphatase activity exhibited by a similar liver enzyme. The non-obese diabetic (NOD) mouse is a model for human type 1 diabetes, an autoimmune disease in which T lymphocytes attack and destroy insulin-producing pancreatic beta cells. In NOD mice, the protein encoded by this gene is a major target of cell-mediated autoimmunity. Variations in the human and mouse genes are associated with lower fasting plasma glucose levels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. "
> "Q8CG19-1","NP_001318166.1","latent-transforming growth factor beta-binding protein 1 isoform 7 precursor","1341",""
13659a13587
> "Q9DB50-1","NP_001277307.1","AP-1 complex subunit sigma-2 isoform 2","157",""
13661,13665c13589,13592
< "Q9WTN0-1","NP_034412.1","geranylgeranyl pyrophosphate synthase isoform 1","300",""
< "P47708-1","NP_035416.1","rabphilin-3A","681",""
< "Q9WUA2-1","NP_035941.2","phenylalanine--tRNA ligase beta subunit","589",""
< "Q9D236-3","NP_084403.2","serine protease HTRA3 isoform a precursor","459",""
< "Q9Z186-1","NP_067306.1","glucose-6-phosphatase 2 isoform 1","355","This gene encodes an enzyme that belongs to the glucose-6-phosphatase catalytic subunit family. Members of this family catalyze the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, to release glucose into the bloodstream. The family member encoded by this gene is found specifically in pancreatic islets but has not been shown to have phosphotransferase or phosphatase activity exhibited by a similar liver enzyme. The non-obese diabetic (NOD) mouse is a model for human type 1 diabetes, an autoimmune disease in which T lymphocytes attack and destroy insulin-producing pancreatic beta cells. In NOD mice, the protein encoded by this gene is a major target of cell-mediated autoimmunity. Variations in the human and mouse genes are associated with lower fasting plasma glucose levels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. "
---
> "O70458-1","NP_001297398.1","oncostatin-M-specific receptor subunit beta isoform 2 precursor","970",""
> "P41971-1","NP_001309194.1","ETS domain-containing protein Elk-3 isoform Elk3c","211",""
> "Q3TWL2-1","NP_001028443.1","type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 1","284",""
> "Q91Z31-1","NP_001297640.1","polypyrimidine tract-binding protein 2 isoform 2","531",""
13667c13594
< "Q9D2A5-1","NP_084356.1","cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1","370","This gene encodes a CREB (cyclic AMP-responsive element-binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein may play a role in adiposity and male germ cell development. Homozygous knockout mice for this gene show increased adipogenesis, elevated testicular germ cell apoptosis and defects in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
---
> "Q9JK91-1","NP_001311451.1","DNA mismatch repair protein Mlh1 isoform 2","519",""
13670,13671c13597,13601
< "Q62141-4","NP_033214.2","paired amphipathic helix protein Sin3b isoform 1","1098",""
< "Q8K1M6-1","NP_690029.2","dynamin-1-like protein isoform a","712","This gene encodes a member of the dynamin family. The encoded protein is localized to the cytoplasm and mitochondrial membrane, is involved in mitochondrial and peroxisomal division, and is essential for mitochondrial fission. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Feb 2013]. "
---
> "P70352-1","NP_001278283.1","ecto-ADP-ribosyltransferase 5 precursor","309",""
> "O70161-1","NP_001140159.1","phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 2","635",""
> "Q9JJJ7-1","NP_001295403.1","protein-serine O-palmitoleoyltransferase porcupine isoform E","227",""
> "Q99LH4-1","NP_001243445.1","zinc finger protein 672","468",""
> "P21836-1","NP_001276939.1","acetylcholinesterase precursor","614",""
13673c13603
< "Q9CQ33-1","NP_080084.2","leucine-zipper-like transcriptional regulator 1 isoform 1","837","This gene encodes a member of the BR-C, ttk and bab-kelch superfamily that, in humans, localizes to the Golgi network and is associated with the ras / mitogen-activated protein kinase pathway. Loss-of-function mutations in the human ortholog are associated with glioblastoma multiforme, schwannomatosis, Noonan syndrome, and DiGeorge syndrome. [provided by RefSeq, Sep 2016]. "
---
> "Q02526-1","NP_001038183.1","zinc finger protein 41","198",""
13675,13677c13605,13607
< "S4R2P9-1","NP_536688.2","sodium/calcium exchanger 3 isoform 2 precursor","928",""
< "O70622-1","NP_038676.1","reticulon-2 isoform B","471",""
< "Q9Z0H8-1","NP_034120.2","CAP-Gly domain-containing linker protein 2 isoform a","1047",""
---
> "P10630-1","NP_001116509.1","eukaryotic initiation factor 4A-II isoform b","312",""
> "Q9JMH9-3","NP_001278141.1","unconventional myosin-XVIIIa isoform 3","2047",""
> "Q99K48-1","NP_001239447.1","non-POU domain-containing octamer-binding protein","473",""
13678a13609
> "P61202-1","NP_001272441.1","COP9 signalosome complex subunit 2 isoform c","319",""
13682a13614,13615
> "O08792-1","NP_001263316.1","transcription factor COE2","575",""
> "Q8BH48-1","NP_001277383.1","ubiquitin-associated protein 1 isoform 2","441",""
13685,13686c13618,13621
< "Q99P30-1","NP_077766.3","peroxisomal coenzyme A diphosphatase NUDT7 isoform 2","216",""
< "Q60809-1","NP_035265.1","CCR4-NOT transcription complex subunit 7 isoform 1","285",""
---
> "Q80TP3-1","NP_001074828.2","E3 ubiquitin-protein ligase UBR5 isoform 1","2798",""
> "Q91VF6-1","NP_001333628.1","collagen alpha-1(XXVI) chain isoform 2 precursor","438",""
> "Q9D236-3","NP_001036080.1","serine protease HTRA3 isoform b precursor","363",""
> "P70408-1","NP_001303687.1","cadherin-10 preproprotein","788","This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is expressed in the blood-brain barrier and retinal endothelia suggesting a role in the development and maintenance of brain barrier. Alternative splicing results in multiple transcript variants. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 15. [provided by RefSeq, Oct 2015]. "
13689d13623
< "Q9Z2V5-1","NP_034543.3","histone deacetylase 6","1149",""
13690a13625
> "P97769-1","NP_001263395.1","cbp/p300-interacting transactivator 1 isoform a","203",""
13691a13627
> "P50153-1","NP_001289926.1","guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor","75","This gene encodes the gamma subunit of the heterotrimeric G-proteins that are comprised of alpha, beta and gamma subunits. Upon activation by G protein-coupled receptors, the beta-gamma heterodimer dissociates from the alpha subunit to activate downstream signaling events. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]. "
13693c13629
< "P60894-1","NP_659503.1","probable G-protein coupled receptor 85","370",""
---
> "Q9D1T0-1","NP_001298005.1","leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 1 precursor","620",""
13696,13699c13632,13633
< "Q3UH66-1","NP_083637.2","serine/threonine-protein kinase WNK2 isoform c","2059",""
< "Q8K097-1","NP_082500.2","protein lifeguard 2 isoform 1","317",""
< "O88935-2","NP_038708.3","synapsin-1 isoform a","706",""
< "Q8K3I9-1","NP_573499.2","glucocorticoid-induced transcript 1 protein isoform 1","538",""
---
> "P70121-1","NP_001035903.1","zinc fingers and homeoboxes protein 1","873",""
> "Q09143-1","NP_001288353.1","high affinity cationic amino acid transporter 1","622",""
13700a13635
> "Q62048-1","NP_001316798.1","astrocytic phosphoprotein PEA-15 isoform 2","130","This gene encodes an adaptor protein that functions as a negative regulator of apoptosis induced by tumor necrosis factor-alpha, tumor necrosis factor-related apoptosis-inducing ligand, and Fas, through its interaction with fas-associated protein with death domain and caspase-8. It also regulates proliferation signaling by relocating the extracellular signal-regulated protein kinases 1 and 2 to the cytosol. The protein encoded by this gene contains an N-terminal death effector domain and a long, flexible C-terminal tail. In humans, the encoded protein is an endogenous substrate for protein kinase C. This protein is overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]. "
13702d13636
< "Q61548-1","NP_038697.1","clathrin coat assembly protein AP180 isoform 1","901",""
13705c13639,13640
< "P70121-1","NP_033598.2","zinc fingers and homeoboxes protein 1","873",""
---
> "Q99P30-1","NP_001277109.1","peroxisomal coenzyme A diphosphatase NUDT7 isoform 3","207",""
> "Q60809-1","NP_001258471.1","CCR4-NOT transcription complex subunit 7 isoform 1","285",""
13707a13643
> "P18894-1","NP_001273325.1","D-amino-acid oxidase isoform 1","345",""
13711,13713c13647,13650
< "P61202-1","NP_034069.2","COP9 signalosome complex subunit 2 isoform b","443",""
< "Q6NZL8-1","NP_073560.2","signal peptide, CUB and EGF-like domain-containing protein 1 isoform b precursor","988",""
< "Q6P073-1","NP_067377.4","ubiquitin-conjugating enzyme E2 J2 isoform a","271",""
---
> "Q61171-1","NP_001304314.1","peroxiredoxin-2","198",""
> "P47708-1","NP_001289273.1","rabphilin-3A","681",""
> "P63277-4","NP_001075447.1","amelogenin, X isoform isoform 1 precursor","219",""
> "O88932-1","NP_001034145.1","ATP-sensitive inward rectifier potassium channel 15 isoform b","375",""
13718c13655
< "P84078-1","NP_031502.1","ADP-ribosylation factor 1","181",""
---
> "Q3URD3-1","NP_001297374.1","sarcolemmal membrane-associated protein isoform 1","845",""
13720d13656
< "Q8VHG2-1","NP_695231.3","angiomotin isoform 1","1126",""
13725,13726d13660
< "P23298-1","NP_032882.2","protein kinase C eta type isoform 1","683","Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in the human gene are associated with susceptibility to cerebral infarction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. "
< "Q9WUF3-1","NP_036127.2","CASP8-associated protein 2","1962",""
13728c13662,13663
< "P28474-1","NP_031436.2","alcohol dehydrogenase class-3 isoform 1","374",""
---
> "Q08943-1","NP_001129553.1","FACT complex subunit SSRP1","708",""
> "Q5FWI3-1","NP_001028931.1","cell surface hyaluronidase","1383",""
13729a13665
> "Q3ZK22-1","NP_001291501.1","vezatin isoform 2","617","This gene encodes a transmembrane protein that is essential for the formation of adherens junctions. It is required for both the pre-implantation morphogenesis of a blastocyst and for the implantation process. The encoded protein is also a component of the ankle-link complex in cochlear hair cells, where it may effect resilience to sound trauma. It is also thought to be involved in dendritic spine morphogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]. "
13732,13734d13667
< "O35638-1","NP_067440.3","cohesin subunit SA-2 isoform 1","1231",""
< "P57776-1","NP_083939.1","elongation factor 1-delta isoform a","660",""
< "Q9CZA6-1","NP_075806.2","nuclear distribution protein nudE homolog 1 isoform a","344",""
13736,13738d13668
< "O70161-1","NP_032870.2","phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 1","661",""
< "O88346-1","NP_035748.1","troponin T, slow skeletal muscle isoform 2","261","This gene encodes the slow skeletal tropomyosin-binding subunit of the troponin complex and plays an essential role in the regulation of striated muscle contraction. In humans, mutations in this gene are associated with nemaline myopathy type 5. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]. "
< "Q80VW5-1","NP_082916.1","whirlin isoform 1","907","This gene encodes a protein required for elongation and actin polymerization in the hair cell stereocilia. The encoded protein is localized to the cytoplasm and co-localizes with the growing end of actin filaments. Mutations in this gene have been linked to deafness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]. "
13739a13670
> "P17183-1","NP_001289571.1","gamma-enolase isoform 2","315",""
13742,13743c13673,13676
< "Q99K48-1","NP_075633.2","non-POU domain-containing octamer-binding protein","473",""
< "P56931-1","NP_808401.1","transcription factor E2F2 isoform 1","443",""
---
> "P47915-1","NP_001311462.1","60S ribosomal protein L29","160",""
> "Q8VDD8-1","NP_001032846.1","WASH complex subunit 1","475",""
> "Q922J3-1","NP_001278158.1","CAP-Gly domain-containing linker protein 1 isoform b","1315",""
> "P11352-1","NP_001316456.1","glutathione peroxidase 1 isoform 2","200","The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Knockout mice lacking this gene are highly sensitive to oxidants, and develop mature cataracts due to damage to the eye lens nucleus. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]. "
13745,13746c13678,13681
< "Q91V88-1","NP_277060.2","nephronectin isoform a precursor","578",""
< "P22091-1","NP_035657.1","T-cell acute lymphocytic leukemia protein 1 homolog","329",""
---
> "Q5IRJ6-1","NP_001297558.1","zinc transporter 9 isoform 2","547",""
> "Q64332-1","NP_001104485.1","synapsin-2 isoform IIa","586",""
> "O35493-1","NP_001291673.1","dual specificity protein kinase CLK4 isoform 2","301",""
> "Q925J9-1","NP_001073587.1","mediator of RNA polymerase II transcription subunit 1 isoform 3","1575",""
13749,13750c13684
< "P07147-1","NP_112479.1","5,6-dihydroxyindole-2-carboxylic acid oxidase precursor","537",""
< "P60904-1","NP_058055.1","dnaJ homolog subfamily C member 5","198",""
---
> "Q9R1T2-1","NP_001272820.1","SUMO-activating enzyme subunit 1 isoform a","350",""
13751a13686
> "Q9CQ33-1","NP_001318155.1","leucine-zipper-like transcriptional regulator 1 isoform 2","750","This gene encodes a member of the BR-C, ttk and bab-kelch superfamily that, in humans, localizes to the Golgi network and is associated with the ras / mitogen-activated protein kinase pathway. Loss-of-function mutations in the human ortholog are associated with glioblastoma multiforme, schwannomatosis, Noonan syndrome, and DiGeorge syndrome. [provided by RefSeq, Sep 2016]. "
13754c13689
< "P0CG49-1","NP_035794.1","polyubiquitin-B","305","This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of four direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Pseudogenes of this gene are located on chromosomes 3 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. "
---
> "Q91WE6-1","NP_001295415.1","threonylcarbamoyladenosine tRNA methylthiotransferase isoform 2","136",""
13758c13693
< "P17532-1","NP_033440.1","tryptophan 5-hydroxylase 1 isoform 1","447","This gene encodes a member of the biopterin-dependent aromatic amino acid hydroxylase family. The encoded protein is one of two tryptophan hydroxylase enzymes that catalyze the first and rate limiting step in the biosynthesis of the hormone and neurotransmitter, serotonin. This gene is expressed in peripheral organs, while tryptophan hydroxylase 2 is expressed in neurons. The encoded protein is involved in the development of hypoxia-induced elevations in pulmonary pressures and pulmonary vascular remodeling, and has also been implicated as a regulator of immune tolerance. Disruption of this gene is associated with cardiac dysfunction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]. "
---
> "Q78ZA7-1","NP_001272418.1","nucleosome assembly protein 1-like 4 isoform a","386",""
13761d13695
< "Q99J27-1","NP_056543.2","acetyl-coenzyme A transporter 1 isoform 1","550",""
13762a13697
> "P70174-1","NP_001239571.1","histamine H1 receptor","488",""
13764,13767c13699,13701
< "Q04735-1","NP_035179.1","cyclin-dependent kinase 16 isoform 1","496",""
< "P16646-1","NP_032911.1","peripheral myelin protein 22 isoform 1","160",""
< "Q8VCW4-1","NP_062322.2","protein unc-93 homolog B1 isoform a","619",""
< "Q8BIF2-1","NP_001272367.1","RNA binding protein fox-1 homolog 3 isoform 3","313",""
---
> "P12025-1","NP_001012335.1","midkine isoform a precursor","140","This gene encodes a secreted growth factor that belongs to the pleiotrophin/midkine heparin-binding protein family and functions in a variety of biological processes. The encoded cytokine promotes the growth, differentiation, survival and migration of several target cells including leucocytes involved in inflammation. This protein plays a role in the formation of scar tissue and intraperitoneal adhesions, and promotes neurite outgrowth and neuron survival. The protein encoded by this gene is associated with obesity and inhibition of insulin signaling in fat cells. A pseudogene of this gene is present on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]. "
> "P0CG49-1","NP_001300913.1","polyubiquitin-B","305","This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of four direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Pseudogenes of this gene are located on chromosomes 3 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. "
> "P97718-1","NP_001258689.1","alpha-1A adrenergic receptor isoform 1","466","This gene encodes one of several multipass transmembrane proteins that function as G protein-coupled receptors. The encoded protein binds to epinephrine and norepinephrine to mediate signaling in cells of the cardiac, nervous, and other organ systems. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]. "
13769d13702
< "Q99JW2-1","NP_079647.1","aminoacylase-1","408",""
13771a13705
> "P34927-1","NP_001278060.1","asialoglycoprotein receptor 1 isoform a","284",""
13774,13775d13707
< "Q8CJ67-1","NP_079579.2","double-stranded RNA-binding protein Staufen homolog 2 isoform 3","570",""
< "Q99246-2","NP_083257.2","voltage-dependent L-type calcium channel subunit alpha-1D isoform 1","2166","This gene encodes a pore-forming subunit of the L-type, voltage-activated calcium channel family. These channels have been found to play a role in heart and smooth muscle contraction and in the transmission of auditory information. Homozygous knockout mice for this gene exhibit deafness and heart defects. These channels have also been linked to mitochondrial oxidative stress in a mouse model of Parkinson's disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]. "
13776a13709
> "P19783-1","NP_001280488.1","cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform 2","169",""
13777a13711
> "Q8R3L2-1","NP_001032966.1","transcription factor 25 isoform a","626",""
13780c13714,13715
< "O55047-1","NP_001281263.1","serine/threonine-protein kinase tousled-like 2 isoform E","697",""
---
> "Q9Z0H8-1","NP_001034251.1","CAP-Gly domain-containing linker protein 2 isoform b","1012",""
> "P22091-1","NP_001274317.1","T-cell acute lymphocytic leukemia protein 1 homolog","329",""
13784a13720,13721
> "Q62009-1","NP_001185694.1","periostin isoform 2 precursor","810","This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. "
> "Q5SP85-1","NP_001160133.1","coiled-coil domain-containing protein 85A isoform 2","460",""
13790d13726
< "P97718-1","NP_038489.2","alpha-1A adrenergic receptor isoform 1","466","This gene encodes one of several multipass transmembrane proteins that function as G protein-coupled receptors. The encoded protein binds to epinephrine and norepinephrine to mediate signaling in cells of the cardiac, nervous, and other organ systems. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]. "
13792,13797c13728,13729
< "Q9WTU3-1","NP_035453.2","sodium channel protein type 8 subunit alpha isoform 2","1978",""
< "Q3TWL2-1","NP_001297436.1","type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 4","231",""
< "Q9EPL2-1","NP_075538.1","calsyntenin-1 isoform 1 precursor","979",""
< "P51432-1","NP_032900.2","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform b","1234",""
< "Q6NS60-1","NP_001276604.1","F-box only protein 41","873",""
< "Q922J3-1","NP_062739.2","CAP-Gly domain-containing linker protein 1 isoform a","1391",""
---
> "Q9JMK2-1","NP_001276827.1","casein kinase I isoform epsilon isoform a","416","The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]. "
> "P56931-1","NP_001292328.1","transcription factor E2F2 isoform 2","224",""
13799a13732,13733
> "Q91WA1-1","NP_001311485.1","TIMELESS-interacting protein","278","The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM and aids in protecting cells against DNA damage and stress. [provided by RefSeq, Feb 2014]. "
> "Q8VBT3-1","NP_001277306.1","osteoclast-associated immunoglobulin-like receptor isoform 2 precursor","265",""
13800a13735,13736
> "O08739-1","NP_001263230.1","AMP deaminase 3 isoform 1","766","This gene encodes a member of the adenosine and AMP deaminases family. The encoded protein is an AMP deaminase involved in nucleotide and energy metabolism in erythrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
> "O88676-1","NP_001307164.1","matrix metalloproteinase-23 isoform 2","377","This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded protein contains an N-terminal cysteine array and a novel immunoglobulin-fold domain at the C-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing. [provided by RefSeq, Feb 2016]. "
13802d13737
< "Q8CG19-1","NP_996841.1","latent-transforming growth factor beta-binding protein 1 isoform LTBP-1S precursor","1394",""
13804c13739
< "Q5FWI3-1","NP_114386.3","cell surface hyaluronidase","1383",""
---
> "Q61233-1","NP_001234913.1","plastin-2","627",""
13808d13742
< "Q9JJZ8-1","NP_034048.1","cyclic nucleotide-gated cation channel alpha-3 isoform 2","631",""
13809a13744,13745
> "Q8VDJ3-1","NP_001288293.1","vigilin","1268",""
> "Q60592-1","NP_001036208.1","microtubule-associated serine/threonine-protein kinase 2 isoform 1","1800",""
13812,13815c13748,13749
< "Q8BHY3-1","NP_848757.4","anoctamin-1 isoform 1","1017",""
< "O08992-1","NP_058087.2","syntenin-1 isoform 2","298",""
< "P10630-1","NP_038534.2","eukaryotic initiation factor 4A-II isoform a","407",""
< "Q91X17-1","NP_033496.1","uromodulin preproprotein","642","This gene encodes a glycoprotein that is the most abundant protein in mammalian urine under physiological conditions. It is synthesized in the kidney as a glycosyl-phosphatidylinositol anchored protein and released into urine as a soluble form by proteolytic cleavage. It is thought to regulate water and salt balance in the thick ascending limb of Henle and to protect against urinary tract infection and calcium oxalate crystal formation. In mouse deficiency of this gene is associated with increased susceptibility to bacterial infections and formation of calcium crystals in kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. "
---
> "P56399-1","NP_001313523.1","ubiquitin carboxyl-terminal hydrolase 5 isoform 2","835",""
> "P21550-1","NP_001129534.1","beta-enolase","434","This gene encodes one of the three enolase isoenzymes found in vertebrates. Enolase is a dimeric enzyme that converts 2-phosphoglycerate to phosphoenolpyruvate as part of the glycolytic pathway. This isozyme is found in skeletal muscle where it is involved in muscle development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
13817,13818c13751,13752
< "P27699-1","NP_038526.2","cAMP-responsive element modulator isoform 3","245","This gene encodes a basic-leucine zipper domain-containing protein that localizes to gene promoters, where it binds to the cyclic AMP response element (CRE). Different protein isoforms encoded by this gene may function as either activators or repressors of transcription. Activity of this gene is important in multiple developmental processes, including spermatogenesis. Mutation of this gene causes male infertility. Alternative splicing and promoter usage result in multiple transcript variants for this gene. [provided by RefSeq, Oct 2012]. "
< "P97797-1","NP_031573.2","tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor","509",""
---
> "Q8R4F1-1","NP_001292734.1","netrin-G2 isoform c precursor","564","The protein encoded by this gene belongs to a subclass of the netrin family called netrin-G proteins. Unlike classic netrins, which act as diffusible chemoattractants, netrin-Gs are glycosylphosphatidylinositol-anchored membrane proteins that interact with specific transmembrane proteins. In mouse, this gene is preferentially expressed in the cerebral cortex, habenular nucleus and superior colliculus. Knockout mutant mice display a lack of behavioral startle in response to acoustic stimuli. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
> "Q8C437-1","NP_001156988.1","PEX5-related protein isoform 2","567",""
13820c13754
< "Q3UNH4-1","NP_036144.2","G protein-regulated inducer of neurite outgrowth 1","932",""
---
> "Q8K3I9-1","NP_001273657.1","glucocorticoid-induced transcript 1 protein isoform 2","351",""
13823,13824c13757,13758
< "O88561-1","NP_036118.2","solute carrier family 27 member 3 isoform 1 precursor","667",""
< "P40753-1","NP_032752.1","natriuretic peptides B isoform 1 preproprotein","121","This gene encodes a secreted protein that belongs to the family of natriuretic peptides. Its precursor protein is processed to generate the active mature peptide. The mature peptide is a cardiac hormone that plays a role in ventricular remodeling as well as blood pressure regulation. Mice lacking this gene exhibit cardiac fibrosis. In humans this gene is associated with congestive heart failure, low bone-mineral density and postmenopausal osteoporosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]. "
---
> "Q8VHG2-1","NP_001277203.1","angiomotin isoform 2","853",""
> "P60894-1","NP_001317595.1","probable G-protein coupled receptor 85","370",""
13826c13760,13761
< "Q8K352-1","NP_083049.1","SAM and SH3 domain-containing protein 3 isoform 2","380",""
---
> "Q9WUA2-1","NP_001265004.1","phenylalanine--tRNA ligase beta subunit","589",""
> "Q9JHG6-1","NP_001075018.1","calcipressin-1 isoform 1","251",""
13829,13830c13764
< "Q78ZA7-1","NP_032698.1","nucleosome assembly protein 1-like 4 isoform b","375",""
< "Q8VBT3-1","NP_783440.1","osteoclast-associated immunoglobulin-like receptor isoform 1 precursor","271",""
---
> "Q91V88-1","NP_001025007.1","nephronectin isoform b precursor","561",""
13832a13767
> "Q8CJ67-1","NP_001104742.1","double-stranded RNA-binding protein Staufen homolog 2 isoform 2","538",""
13835c13770
< "Q9R1T2-1","NP_062722.1","SUMO-activating enzyme subunit 1 isoform a","350",""
---
> "Q99246-2","NP_001077085.1","voltage-dependent L-type calcium channel subunit alpha-1D isoform 2","2144","This gene encodes a pore-forming subunit of the L-type, voltage-activated calcium channel family. These channels have been found to play a role in heart and smooth muscle contraction and in the transmission of auditory information. Homozygous knockout mice for this gene exhibit deafness and heart defects. These channels have also been linked to mitochondrial oxidative stress in a mouse model of Parkinson's disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]. "
13837d13771
< "Q8K0T0-1","NP_703187.2","reticulon-1 isoform A","780",""
13839c13773
< "P70331-1","NP_034913.2","myoD family inhibitor isoform 1","246",""
---
> "Q9Z2V5-1","NP_001123888.1","histone deacetylase 6","1149",""
13844,13848c13778
< "O08739-1","NP_033797.2","AMP deaminase 3 isoform 1","766","This gene encodes a member of the adenosine and AMP deaminases family. The encoded protein is an AMP deaminase involved in nucleotide and energy metabolism in erythrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
< "P35377-1","NP_035142.1","nociceptin receptor isoform 1","367","The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]. "
< "P08043-1","NP_848542.1","zinc finger protein 2","459",""
< "Q8R4F1-1","NP_598008.1","netrin-G2 isoform b precursor","589","The protein encoded by this gene belongs to a subclass of the netrin family called netrin-G proteins. Unlike classic netrins, which act as diffusible chemoattractants, netrin-Gs are glycosylphosphatidylinositol-anchored membrane proteins that interact with specific transmembrane proteins. In mouse, this gene is preferentially expressed in the cerebral cortex, habenular nucleus and superior colliculus. Knockout mutant mice display a lack of behavioral startle in response to acoustic stimuli. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
< "Q8CGF7-1","NP_001276455.1","transcription elongation regulator 1 isoform 2","1096",""
---
> "P40753-1","NP_001274277.1","natriuretic peptides B isoform 2 preproprotein","120","This gene encodes a secreted protein that belongs to the family of natriuretic peptides. Its precursor protein is processed to generate the active mature peptide. The mature peptide is a cardiac hormone that plays a role in ventricular remodeling as well as blood pressure regulation. Mice lacking this gene exhibit cardiac fibrosis. In humans this gene is associated with congestive heart failure, low bone-mineral density and postmenopausal osteoporosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]. "
13850d13779
< "Q9QZS5-1","NP_038759.1","serine/threonine-protein kinase Sgk2 isoform a","367",""
13852d13780
< "Q60829-1","NP_659077.1","protein phosphatase 1 regulatory subunit 1B isoform 1","194","This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders in humans. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
13854a13783,13787
> "P47801-1","NP_001275556.1","epithelial membrane protein 1 isoform a","160",""
> "Q61334-1","NP_001157562.1","B-cell receptor-associated protein 29","240",""
> "Q8BKE9-1","NP_001277497.1","intraflagellar transport protein 74 homolog isoform 2","388",""
> "Q99J27-1","NP_001258964.1","acetyl-coenzyme A transporter 1 isoform 1","550",""
> "Q91W40-1","NP_001272967.1","kinesin light chain 3","508",""
13859,13861c13792
< "P11352-1","NP_032186.2","glutathione peroxidase 1 isoform 1","201","The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Knockout mice lacking this gene are highly sensitive to oxidants, and develop mature cataracts due to damage to the eye lens nucleus. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]. "
< "O70589-1","NP_033936.2","peripheral plasma membrane protein CASK isoform 4","897",""
< "P28301-1","NP_034858.2","protein-lysine 6-oxidase preproprotein","411","This gene encodes a precursor protein that belongs to the lysyl oxidase family of proteins. The secreted proprotein is proteolytically processed to an active mature peptide and a propeptide. This propeptide is thought to function in tumor suppression by inhibiting the Ras signaling pathway. The active enzyme plays a role in cross-linking of collagen and elastin and is essential for development of cardiovascular and respiratory systems, and development of skin and connective tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]. "
---
> "Q6NXW6-1","NP_001037836.1","cell cycle checkpoint protein RAD17 isoform 1","688",""
13867,13868c13798
< "P15947-1","NP_034769.4","kallikrein-1 isoform 1 preproprotein","261","This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein are unable to generate significant levels of kinins in most tissues, develop cardiovascular abnormalities and exhibit hypercalciuria of renal origin. This gene is located in a cluster of several related kallikrein genes on chromosome 7. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, Feb 2016]. "
< "Q9WUZ9-1","NP_031673.2","ectonucleoside triphosphate diphosphohydrolase 5 isoform a","452",""
---
> "Q9DBA9-1","NP_001278004.1","general transcription factor IIH subunit 1 isoform 1","553",""
13871,13872d13800
< "Q9CR14-1","NP_080199.1","E3 ubiquitin-protein ligase FANCL isoform 1","375","This gene encodes the complementation group L subunit of the multimeric Fanconi anemia (FA) nuclear complex composed of proteins encoded by over ten Fanconi anemia complementation (FANC) group genes. The FA complex is necessary for protection against DNA damage. This gene product, an E3 ubiquitin ligase, catalyzes and is required for the monoubiquitination of the protein encoded by the Fanconi anemia, complementation group D2 gene, a critical step in the FA pathway (PMID: 12973351, 21229326). In mouse, mutations of this E3 ubiquitin ligase gene can lead to infertility in adult males and females, and a deletion of this gene can cause embryonic lethality in some genetic backgrounds. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. "
< "Q8CFX1-1","NP_775547.2","GDH/6PGL endoplasmic bifunctional protein isoform 1 precursor","797",""
13875a13804
> "Q810U5-1","NP_001020786.1","coiled-coil domain-containing protein 50 isoform 2","290",""
13877d13805
< "P34927-1","NP_033844.1","asialoglycoprotein receptor 1 isoform a","284",""
13879,13880c13807,13812
< "Q8R3L2-1","NP_080080.2","transcription factor 25 isoform b","625",""
< "Q8R2Y0-1","NP_079617.2","monoacylglycerol lipase ABHD6 isoform 1","336",""
---
> "P48168-1","NP_001268898.1","glycine receptor subunit beta isoform 7","398","This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. This gene is transcribed throughout the central nervous system of neonatal and adult mice. In humans, mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. "
> "Q62159-1","NP_001278788.1","rho-related GTP-binding protein RhoC precursor","193",""
> "Q8VDU5-1","NP_001158044.1","SNF-related serine/threonine-protein kinase","748",""
> "Q8K1M6-1","NP_001021118.1","dynamin-1-like protein isoform b","699","This gene encodes a member of the dynamin family. The encoded protein is localized to the cytoplasm and mitochondrial membrane, is involved in mitochondrial and peroxisomal division, and is essential for mitochondrial fission. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Feb 2013]. "
> "P50285-1","NP_001317220.1","dimethylaniline monooxygenase [N-oxide-forming] 1 isoform 1","532",""
> "P61793-1","NP_001277415.1","lysophosphatidic acid receptor 1 isoform 2","346",""
13881a13814
> "P17532-1","NP_001129556.1","tryptophan 5-hydroxylase 1 isoform 1","447","This gene encodes a member of the biopterin-dependent aromatic amino acid hydroxylase family. The encoded protein is one of two tryptophan hydroxylase enzymes that catalyze the first and rate limiting step in the biosynthesis of the hormone and neurotransmitter, serotonin. This gene is expressed in peripheral organs, while tryptophan hydroxylase 2 is expressed in neurons. The encoded protein is involved in the development of hypoxia-induced elevations in pulmonary pressures and pulmonary vascular remodeling, and has also been implicated as a regulator of immune tolerance. Disruption of this gene is associated with cardiac dysfunction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]. "
13884d13816
< "Q9ESN6-1","NP_109631.2","tripartite motif-containing protein 2 isoform 3","761",""
13890a13823
> "Q8R4Z4-1","NP_001076787.1","ETS translocation variant 3 isoform 1","513",""
13892c13825,13826
< "P19783-1","NP_034071.2","cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform 1","206",""
---
> "Q9QZS5-1","NP_001278081.1","serine/threonine-protein kinase Sgk2 isoform b","366",""
> "P23298-1","NP_001300906.1","protein kinase C eta type isoform 2","570","Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in the human gene are associated with susceptibility to cerebral infarction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. "
13894c13828,13829
< "Q6P1E1-1","NP_899031.2","zinc finger MIZ domain-containing protein 1 isoform 1","1072",""
---
> "P57776-1","NP_001272358.1","elongation factor 1-delta isoform b","281",""
> "P84078-1","NP_001123880.1","ADP-ribosylation factor 1","181",""
13897,13899d13831
< "P70174-1","NP_032311.2","histamine H1 receptor","488",""
< "Q64739-2","NP_034056.1","collagen alpha-2(XI) chain isoform 2 precursor","1650","This gene encodes the alpha-2 subunit of type XI collagen, one of the low abundance fibrillar collagens found in cartilage. The encoded protein, in association with other collagen subunits, forms a heterotrimeric type XI procollagen that may undergo proteolytic processing similar to the alpha-1 subunit. Mice lacking the encoded protein exhibit a mild phenotype similar to nonocular Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED) as well as a nonsyndromic form of deafness called DFNA13. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]. "
< "Q99JB8-1","NP_112019.2","protein kinase C and casein kinase II substrate protein 3","424",""
13900a13833
> "Q8K352-1","NP_001300678.1","SAM and SH3 domain-containing protein 3 isoform 1","381",""
13901a13835,13837
> "Q6P073-1","NP_001034246.1","ubiquitin-conjugating enzyme E2 J2 isoform a","271",""
> "O55047-1","NP_001281260.1","serine/threonine-protein kinase tousled-like 2 isoform B","718",""
> "Q8K0T0-1","NP_001273377.1","reticulon-1 isoform A2","268",""
13904c13840
< "Q9EQN9-1","NP_473428.1","thiamine transporter 1 isoform a","498",""
---
> "Q6NZL8-1","NP_001258401.1","signal peptide, CUB and EGF-like domain-containing protein 1 isoform a precursor","1018",""
13906d13841
< "Q9QWZ1-1","NP_035362.2","cell cycle checkpoint protein RAD1 isoform 1","280",""
13907a13843,13844
> "O88935-2","NP_001104250.1","synapsin-1 isoform b","670",""
> "Q61751-1","NP_001313495.1","zinc finger protein 354A isoform 2","571",""
13908a13846
> "O88522-1","NP_001154895.1","NF-kappa-B essential modulator isoform 1","412",""
13910a13849
> "Q8C9B9-1","NP_001278361.1","death-inducer obliterator 1 isoform Dido1","614","This gene encodes a transcription factor involved in apoptosis. The encoded protein functions in cell cycle progression and plays a role in chromosomal stability. This protein regulates the self-renewal of embryonic stem cells. Disruption of this gene in mice causes symptoms similar to myelodysplastic/myeloproliferative diseases in humans. Mice lacking this gene show severely reduced fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]. "
13915,13916d13853
< "Q08943-1","NP_892035.2","FACT complex subunit SSRP1","708",""
< "Q99MN9-1","NP_080111.1","propionyl-CoA carboxylase beta chain, mitochondrial isoform 1 precursor","541",""
13918,13921c13855,13859
< "Q05512-1","NP_031954.2","serine/threonine-protein kinase MARK2 isoform 1","776",""
< "Q2VPD4-1","NP_758513.1","aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 1","579","This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (Per, Arnt, Sim) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian Clock protein, the structurally related Mop4, and hypoxia-inducible factors, such as Hif1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]. "
< "Q924W9-1","NP_476514.1","rhombotin-1 isoform 1","156",""
< "Q925J9-1","NP_598788.2","mediator of RNA polymerase II transcription subunit 1 isoform 2","556",""
---
> "O35638-1","NP_001071180.1","cohesin subunit SA-2 isoform 1","1231",""
> "Q80TV8-1","NP_001280229.1","CLIP-associating protein 1 isoform 4","1552",""
> "Q80VW5-1","NP_001008791.1","whirlin isoform 2","918","This gene encodes a protein required for elongation and actin polymerization in the hair cell stereocilia. The encoded protein is localized to the cytoplasm and co-localizes with the growing end of actin filaments. Mutations in this gene have been linked to deafness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]. "
> "P24721-1","NP_001300854.1","asialoglycoprotein receptor 2 isoform a","301","This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Sep 2015]. "
> "Q3URR7-1","NP_001028597.2","zinc finger and SCAN domain-containing protein 10 isoform 1","782",""
13922a13861
> "Q9ERZ6-1","NP_001254775.1","fidgetin isoform 2","748",""
13924c13863
< "P50153-1","NP_034447.1","guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor","75","This gene encodes the gamma subunit of the heterotrimeric G-proteins that are comprised of alpha, beta and gamma subunits. Upon activation by G protein-coupled receptors, the beta-gamma heterodimer dissociates from the alpha subunit to activate downstream signaling events. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]. "
---
> "Q60829-1","NP_001300899.1","protein phosphatase 1 regulatory subunit 1B isoform 2","158","This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders in humans. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
13927c13866
< "Q9ERZ6-1","NP_068362.1","fidgetin isoform 1","759",""
---
> "Q8CFX1-1","NP_001277933.1","GDH/6PGL endoplasmic bifunctional protein isoform 2 precursor","789",""
13930,13931c13869
< "Q02526-1","NP_035889.1","zinc finger protein 41","198",""
< "Q9CWT3-1","NP_082311.3","sorting nexin-10 isoform a","201",""
---
> "Q7TN22-1","NP_001297463.1","thioredoxin domain-containing protein 16 isoform 1 precursor","820",""
13932a13871
> "Q9WUZ9-1","NP_001021385.1","ectonucleoside triphosphate diphosphohydrolase 5 isoform b precursor","427",""
13936,13937c13875,13877
< "Q8BKE9-1","NP_080595.2","intraflagellar transport protein 74 homolog isoform 1","600",""
< "Q3URD3-1","NP_114397.3","sarcolemmal membrane-associated protein isoform 2","821",""
---
> "Q3TRM4-1","NP_001116290.2","neuropathy target esterase isoform 1","1345",""
> "Q3UH66-1","NP_001277240.1","serine/threonine-protein kinase WNK2 isoform a","2213",""
> "Q6NS60-1","NP_001001160.1","F-box only protein 41","873",""
13939c13879
< "Q91ZM2-1","NP_035493.2","SH2B adapter protein 1 isoform 2","682",""
---
> "Q8BWB6-1","NP_001096626.1","metalloreductase STEAP2 isoform 1","489",""
13944d13883
< "Q8VDJ3-1","NP_598569.1","vigilin","1268",""
13946,13948c13885,13886
< "O88932-1","NP_062638.1","ATP-sensitive inward rectifier potassium channel 15 isoform b","375",""
< "Q91X46-1","NP_082147.1","rho guanine nucleotide exchange factor 3 isoform 2","531",""
< "P11862-1","NP_032113.1","growth arrest-specific protein 2 isoform 1","314",""
---
> "Q9Z0X1-1","NP_001277293.1","apoptosis-inducing factor 1, mitochondrial isoform 2","608",""
> "Q7TQF7-1","NP_001276475.1","amphiphysin isoform 2","690",""
13950d13887
< "Q8R4Z4-1","NP_036181.3","ETS translocation variant 3 isoform 1","513",""
13952c13889,13891
< "O88676-1","NP_036115.1","matrix metalloproteinase-23 isoform 1 precursor","391","This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded protein contains an N-terminal cysteine array and a novel immunoglobulin-fold domain at the C-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing. [provided by RefSeq, Feb 2016]. "
---
> "Q6P1E1-1","NP_001297595.1","zinc finger MIZ domain-containing protein 1 isoform 2","1066",""
> "Q9CZA6-1","NP_001107557.1","nuclear distribution protein nudE homolog 1 isoform b","317",""
> "O88561-1","NP_001303617.1","solute carrier family 27 member 3 isoform 2","538",""
13954,13956d13892
< "Q9QYA2-1","NP_058567.2","mitochondrial import receptor subunit TOM40 homolog","361",""
< "Q91W40-1","NP_666294.1","kinesin light chain 3","508",""
< "Q8C796-1","NP_473389.2","REST corepressor 2","523",""
13959d13894
< "Q3URR7-1","NP_001276413.1","zinc finger and SCAN domain-containing protein 10 isoform 5","705",""
13962c13897
< "Q9R0M5-1","NP_038889.1","thiamin pyrophosphokinase 1 isoform 1","243",""
---
> "Q8VCW4-1","NP_001154900.1","protein unc-93 homolog B1 isoform b","422",""
13963a13899,13904
> "P27808-1","NP_001103618.1","alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase","447",""
> "Q60823-1","NP_001103678.1","RAC-beta serine/threonine-protein kinase","481",""
> "P70377-1","NP_001277344.1","fibroblast growth factor 13 isoform 3","192",""
> "Q8R4R6-1","NP_001177108.1","nucleoporin NUP35 isoform 2","308",""
> "S4R2P9-1","NP_001161392.1","sodium/calcium exchanger 3 isoform 1 precursor","921",""
> "P19324-1","NP_001104513.1","serpin H1 precursor","417",""
13965a13907
> "Q9ESN6-1","NP_001258654.1","tripartite motif-containing protein 2 isoform 1","770",""
13967d13908
< "P47915-1","NP_033108.1","60S ribosomal protein L29","160",""
13969d13909
< "Q61751-1","NP_033355.2","zinc finger protein 354A isoform 1","572",""
13970a13911
> "Q9CR14-1","NP_001264202.1","E3 ubiquitin-protein ligase FANCL isoform 2","370","This gene encodes the complementation group L subunit of the multimeric Fanconi anemia (FA) nuclear complex composed of proteins encoded by over ten Fanconi anemia complementation (FANC) group genes. The FA complex is necessary for protection against DNA damage. This gene product, an E3 ubiquitin ligase, catalyzes and is required for the monoubiquitination of the protein encoded by the Fanconi anemia, complementation group D2 gene, a critical step in the FA pathway (PMID: 12973351, 21229326). In mouse, mutations of this E3 ubiquitin ligase gene can lead to infertility in adult males and females, and a deletion of this gene can cause embryonic lethality in some genetic backgrounds. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. "
13973c13914
< "P47941-1","NP_031790.2","crk-like protein isoform 1","303","This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In certain mouse genetic backgrounds this protein is essential for embryonic development. It is important for neural crest cell differentiation and survival and is proposed to play an important role in transducing the oncogenic signal of Bcr/Abl. Deletion of this gene in mouse mimics the phenotype of DiGeorge/velocardiofacial syndrome in human. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]. "
---
> "Q99JB8-1","NP_001276606.1","protein kinase C and casein kinase II substrate protein 3","424",""
13975c13916
< "Q5IRJ6-1","NP_848766.2","zinc transporter 9 isoform 1","567",""
---
> "Q9JJZ8-1","NP_001268939.1","cyclic nucleotide-gated cation channel alpha-3 isoform 1","669",""
13976a13918
> "Q9QUG3-1","NP_001119810.1","prion-like protein doppel precursor","179",""
13978c13920,13924
< "P21836-1","NP_033729.1","acetylcholinesterase precursor","614",""
---
> "P28474-1","NP_001275507.1","alcohol dehydrogenase class-3 isoform 2","252",""
> "A1A546-1","NP_001281207.1","intestine-specific homeobox isoform 1","242",""
> "Q9WUK2-1","NP_001299796.1","eukaryotic translation initiation factor 4H isoform 2","228","This gene encodes eukaryotic translation initiation factor 4H (eIF4H) that plays a critical role in the process of protein synthesis. The encoded protein is an RNA-binding protein that, in concert with other translation initiation factors, helps unwind the 5' cap-proximal region of mRNA to prepare it for ribosomal attachment. Mice lacking the encoded protein displayed growth retardation with a significant reduction of body weight, a smaller brain volume and altered brain morphology. Behaviorally, mice lacking the encoded protein exhibit severe impairments of fear-related associative learning and memory formation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]. "
> "Q9D2A5-1","NP_001294863.1","cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1","370","This gene encodes a CREB (cyclic AMP-responsive element-binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein may play a role in adiposity and male germ cell development. Homozygous knockout mice for this gene show increased adipogenesis, elevated testicular germ cell apoptosis and defects in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
> "Q9JHL0-1","NP_064428.1","linker for activation of T-cells family member 2 isoform a precursor","203",""
13980a13927
> "Q924W9-1","NP_001289134.1","rhombotin-1 isoform 2","155",""
13983,13984c13930
< "Q61233-1","NP_032905.2","plastin-2","627",""
< "O08792-1","NP_034225.1","transcription factor COE2","575",""
---
> "O88697-1","NP_001264921.1","serine/threonine-protein kinase 16","305",""
13985a13932,13934
> "P27699-1","NP_001104320.1","cAMP-responsive element modulator isoform 4","233","This gene encodes a basic-leucine zipper domain-containing protein that localizes to gene promoters, where it binds to the cyclic AMP response element (CRE). Different protein isoforms encoded by this gene may function as either activators or repressors of transcription. Activity of this gene is important in multiple developmental processes, including spermatogenesis. Mutation of this gene causes male infertility. Alternative splicing and promoter usage result in multiple transcript variants for this gene. [provided by RefSeq, Oct 2012]. "
> "P15379-14","NP_001034240.1","CD44 antigen isoform c precursor","365",""
> "A2AM05-1","NP_780484.2","centlein isoform 1","1396",""
13988c13937,13938
< "O88522-1","NP_034677.2","NF-kappa-B essential modulator isoform 1","412",""
---
> "Q7TSK2-1","NP_001278154.1","seizure protein 6 isoform 2 precursor","977",""
> "P40645-1","NP_001264255.1","transcription factor SOX-6 isoform 1","827","This gene encodes a member of a family of transcriptional regulators containing high mobility group (HMG) DNA-binding domains. Function of the encoded protein is important for proper cardiac and skeletal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. "
13990c13940
< "Q9Z0X1-1","NP_036149.1","apoptosis-inducing factor 1, mitochondrial isoform 1 precursor","612",""
---
> "O55176-3","NP_001076579.1","E3 ubiquitin-protein ligase Praja-1 isoform 1","578",""
13992c13942
< "P40645-1","NP_035575.1","transcription factor SOX-6 isoform 1","827","This gene encodes a member of a family of transcriptional regulators containing high mobility group (HMG) DNA-binding domains. Function of the encoded protein is important for proper cardiac and skeletal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. "
---
> "P70333-1","NP_001300645.1","heterogeneous nuclear ribonucleoprotein H2","449",""
13997d13946
< "Q8C050-1","NP_705815.1","ribosomal protein S6 kinase alpha-5 isoform 1","863",""
13999c13948,13949
< "O09039-1","NP_032533.1","SH2B adapter protein 3 isoform 1","548","This gene encodes a member of the SH2B family of adapter proteins that play an important role in T cell receptor signaling. This gene is preferentially expressed in hematopoietic stem cells, hematopoietic progenitors, pre and immature B cells, as well as megakaryocytes and mastocytes. In hematopoietic stem cells, the encoded protein is a key regulator of self-renewal, proliferation and apoptosis. Mice lacking the encoded protein exhibit pre and immature B cell expansion in spleen and the bone marrow. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. "
---
> "Q61124-1","NP_001139783.1","battenin isoform 1","438","This gene encodes a transmembrane protein called battenin that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis genes, cause a number of neurodegenerative diseases collectively known as neuronal ceroid lipofuscinoses, the most common of which is juvenile neuronal ceroid-lipofuscinosis (Batten disease). Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]. "
> "Q8BH65-1","NP_001127937.1","protein DENND6A isoform a","605",""
14003,14004c13953,13955
< "Q8VDD8-1","NP_081109.1","WASH complex subunit 1","475",""
< "P70377-1","NP_034330.2","fibroblast growth factor 13 isoform 1","245",""
---
> "Q99JW2-1","NP_001263371.1","aminoacylase-1","408",""
> "P08043-1","NP_001038162.1","zinc finger protein 2","459",""
> "Q05512-1","NP_001073857.1","serine/threonine-protein kinase MARK2 isoform 2","722",""
14006c13957,13958
< "Q9JHG6-1","NP_062339.2","calcipressin-1 isoform 2","198",""
---
> "Q9WVA3-1","NP_001304279.1","mitotic checkpoint protein BUB3","326","This gene encodes a component of the mitotic spindle assembly complex. The encoded protein is involved in the regulation of chromosome segregation during oocyte meiosis. Disruption of this gene results in the accumulation of mitotic errors and is lethal in the embryonic stage. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]. "
> "Q9ESN5-1","NP_068562.1","centromere protein K isoform 1","306",""
14010c13962
< "P15379-14","NP_033981.2","CD44 antigen isoform a precursor","780",""
---
> "Q91ZM2-1","NP_001074928.1","SH2B adapter protein 1 isoform 1","670",""
14011a13964
> "P70331-1","NP_001103443.1","myoD family inhibitor isoform 1","246",""
14013,14014c13966
< "Q9JMH9-3","NP_035716.1","unconventional myosin-XVIIIa isoform 2","2035",""
< "P19324-1","NP_033955.2","serpin H1 precursor","417",""
---
> "P27573-1","NP_001302428.1","myelin protein P0 isoform MPZ precursor","248","This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in the orthologous gene in human are associated with myelinating neuropathies. A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2015]. "
14016,14017c13968,13970
< "Q8C437-1","NP_001156989.1","PEX5-related protein isoform 3","344",""
< "P28661-1","NP_035259.1","septin-4 isoform 1","478",""
---
> "Q3UIZ8-1","NP_001284541.1","myosin light chain kinase 3 isoform 2","662",""
> "Q08460-1","NP_001240294.1","calcium-activated potassium channel subunit alpha-1 isoform 9","1234",""
> "Q3UNH4-1","NP_001303639.1","G protein-regulated inducer of neurite outgrowth 1","932",""
14023a13977
> "Q8BVA5-1","NP_001161239.1","lipid droplet-associated hydrolase isoform 2","236",""
14031,14032d13984
< "Q91VF6-1","NP_077794.2","collagen alpha-1(XXVI) chain isoform 1 precursor","440",""
< "P29387-1","NP_038559.2","guanine nucleotide-binding protein subunit beta-4 isoform 1","340",""
14037a13990
> "P62482-1","NP_001239585.1","voltage-gated potassium channel subunit beta-2 isoform 1","367",""
14046d13998
< "Q9D1T0-1","NP_851419.1","leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor","614",""
14053a14006
> "P70387-1","NP_001334422.1","hereditary hemochromatosis protein homolog isoform b precursor","271",""
14058d14010
< "P80316-1","NP_031663.1","T-complex protein 1 subunit epsilon isoform 1","541",""
14060a14013
> "Q61548-1","NP_001264911.1","clathrin coat assembly protein AP180 isoform 3","868",""
14063d14015
< "Q9QXE4-1","NP_068697.1","tumor protein p53-inducible nuclear protein 1 isoform 1","239",""
14065a14018
> "P80316-1","NP_001334964.1","T-complex protein 1 subunit epsilon isoform 2","503",""
14066a14020
> "Q9D415-1","NP_001334340.1","disks large-associated protein 1 isoform 5","964",""
14069,14070d14022
< "Q9Z2C5-1","NP_064310.2","myotubularin isoform 1","603",""
< "Q8BYH0-1","NP_001334519.1","dorsal root ganglia homeobox protein isoform 1","263",""
14075d14026
< "P62482-1","NP_034728.2","voltage-gated potassium channel subunit beta-2 isoform 1","367",""
14076a14028
> "Q8R4P9-1","NP_001334325.1","multidrug resistance-associated protein 7 isoform 3","1526","The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]. "
14100c14052,14053
< "Q80U78-1","NP_109647.2","pumilio homolog 1 isoform 1","1189",""
---
> "Q9DCT8-1","NP_001334372.1","cysteine-rich protein 2 isoform 2","84",""
> "Q924H5-1","NP_001278369.1","DNA repair protein RAD51 homolog 3 isoform 1","384",""
14103d14055
< "Q60996-1","NP_036153.2","serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform a","524",""
14107d14058
< "P24788-1","NP_031687.2","cyclin-dependent kinase 11B isoform 1","784",""
14110d14060
< "Q924H5-1","NP_444499.1","DNA repair protein RAD51 homolog 3 isoform 2","366",""
14112a14063
> "Q9Z2Y3-1","NP_001271118.1","homer protein homolog 1 isoform b","354",""
14113a14065
> "Q60634-1","NP_001035493.1","flotillin-2 isoform 1","428",""
14119a14072
> "Q58A65-1","NP_001020599.1","C-Jun-amino-terminal kinase-interacting protein 4 isoform 2","1169",""
14131a14085
> "Q8R5L3-1","NP_671495.1","vam6/Vps39-like protein isoform 1","886",""
14134d14087
< "Q5EE38-1","NP_001335278.1","adrenocortical dysplasia protein isoform 2","225",""
14141d14093
< "P97872-1","NP_034362.2","dimethylaniline monooxygenase [N-oxide-forming] 5 isoform 1","533",""
14142a14095
> "Q9Z140-1","NP_001129529.1","copine-6 isoform a","557","Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2018]. "
14148a14102
> "P24788-1","NP_001334237.1","cyclin-dependent kinase 11B isoform 2","750",""
14151d14104
< "Q8VI67-1","NP_569725.1","transcription factor Sp7 isoform 1","428",""
14152a14106
> "P63163-1","NP_001076430.1","small nuclear ribonucleoprotein-associated protein N","240","This locus represents a paternally-expressed imprinted gene that encodes a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing. Genomic and genetic changes in this region result in growth defects and lethality; the corresponding region in human is the critical region for Prader-Willi Syndrome. Alternative promoter use and alternative splicing result in a multitude of transcript variants encoding the same protein. Transcript variants may be bicistronic and also encode the SNRPN upstream reading frame protein (Snurf) from an upstream open reading frame. In addition, long spliced transcripts for small nucleolar RNA host gene 14 (Snhg14) may originate from the promoters at this locus and incorporate exons shared with this gene. [provided by RefSeq, Mar 2017]. "
14154c14108
< "Q9QZX7-1","NP_038789.1","serine racemase isoform 1","339",""
---
> "P20826-1","NP_001334085.1","kit ligand isoform 2 precursor","245",""
14155a14110
> "Q6ZQ29-1","NP_001157246.1","serine/threonine-protein kinase TAO2 isoform 1","1055",""
14160d14114
< "Q3UMF0-1","NP_795999.2","cordon-bleu protein-like 1 isoform 1","1240",""
14162d14115
< "Q91V17-1","NP_573469.1","E3 ubiquitin-protein ligase ZNRF1 isoform a","227",""
14188d14140
< "Q8R5L3-1","NP_849182.1","vam6/Vps39-like protein isoform 2","875",""
14193a14146
> "Q61458-1","NP_001334516.1","cyclin-H isoform b","287",""
14195a14149
> "Q8VC66-1","NP_001240697.1","afadin- and alpha-actinin-binding protein isoform b","614",""
14201d14154
< "Q8K596-1","NP_683748.1","sodium/calcium exchanger 2 isoform 1 precursor","921",""
14207d14159
< "Q8VC66-1","NP_620083.1","afadin- and alpha-actinin-binding protein isoform a","615",""
14209a14162
> "Q91WG8-1","NP_001177343.1","bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 1","722",""
14211a14165
> "Q5EE38-1","NP_001012656.1","adrenocortical dysplasia protein isoform 1","416",""
14214d14167
< "Q6ZQ29-1","NP_001157247.1","serine/threonine-protein kinase TAO2 isoform 2","1240",""
14219d14171
< "P70387-1","NP_034554.2","hereditary hemochromatosis protein homolog isoform a precursor","359",""
14223d14174
< "Q60634-1","NP_032054.1","flotillin-2 isoform 2","379",""
14224a14176
> "O89033-1","NP_001020950.1","cell division control protein 6 homolog isoform b","562",""
14225a14178,14179
> "Q9QZX7-1","NP_001156783.1","serine racemase isoform 1","339",""
> "P05214-1","NP_033472.1","tubulin alpha-3 chain","450",""
14226a14181
> "Q9CQJ7-1","NP_001124526.1","securin isoform 1","199",""
14235c14190
< "P50540-1","NP_034977.1","max-interacting protein 1 isoform a","228","This gene encodes a protein containing a helix-loop-helix domain characteristic of transcription factors, which allows heterodimerization and sequence-specific DNA binding. The encoded protein is related to a family of Myc/Max/Mad proteins that are involved in the regulation of several cellular processes. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate Myc function. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. "
---
> "P24399-1","NP_001001792.1","zinc finger protein 239","201",""
14238a14194
> "Q99JF8-1","NP_001277456.1","PC4 and SFRS1-interacting protein isoform 2","331",""
14258a14215
> "Q91V17-1","NP_001162092.1","E3 ubiquitin-protein ligase ZNRF1 isoform a","227",""
14260a14218
> "Q6DIC0-1","NP_001334368.1","probable global transcription activator SNF2L2 isoform 3 precursor","276",""
14262a14221
> "Q8VHX6-1","NP_001074654.1","filamin-C isoform 1","2726",""
14266d14224
< "P63163-1","NP_038698.1","small nuclear ribonucleoprotein-associated protein N","240","This locus represents a paternally-expressed imprinted gene that encodes a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing. Genomic and genetic changes in this region result in growth defects and lethality; the corresponding region in human is the critical region for Prader-Willi Syndrome. Alternative promoter use and alternative splicing result in a multitude of transcript variants encoding the same protein. Transcript variants may be bicistronic and also encode the SNRPN upstream reading frame protein (Snurf) from an upstream open reading frame. In addition, long spliced transcripts for small nucleolar RNA host gene 14 (Snhg14) may originate from the promoters at this locus and incorporate exons shared with this gene. [provided by RefSeq, Mar 2017]. "
14274a14233
> "A2AFR3-1","NP_001028502.1","FERM and PDZ domain-containing protein 4 isoform a","1312",""
14277a14237
> "O35732-1","NP_001276633.1","CASP8 and FADD-like apoptosis regulator isoform 1","481",""
14284d14243
< "Q8BKX7-1","NP_659082.1","zinc finger protein 410 isoform 1","478",""
14286d14244
< "Q9Z140-1","NP_034077.1","copine-6 isoform a","557","Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2018]. "
14290d14247
< "Q8VHX6-1","NP_001298003.1","filamin-C isoform 2","2693",""
14293a14251
> "P45878-1","NP_001159840.1","peptidyl-prolyl cis-trans isomerase FKBP2 precursor","140",""
14297a14256
> "Q8CAQ8-1","NP_001240610.1","MICOS complex subunit Mic60 isoform 2","746",""
14301c14260
< "Q8VCQ6-1","NP_659041.3","phosphatidylcholine:ceramide cholinephosphotransferase 1","419",""
---
> "Q80U78-1","NP_001153075.1","pumilio homolog 1 isoform 2","1186",""
14306d14264
< "Q9D2P8-1","NP_032640.1","myelin-associated oligodendrocyte basic protein isoform a","81",""
14319,14320c14277
< "P24399-1","NP_032642.2","zinc finger protein 239","201",""
< "Q8BX57-1","NP_840063.1","PX domain-containing protein kinase-like protein short isoform","515",""
---
> "Q8BH06-1","NP_001029201.1","interleukin-17 receptor E isoform 2","436",""
14324a14282
> "Q9CZ04-1","NP_001157561.1","COP9 signalosome complex subunit 7a isoform 2","277",""
14327d14284
< "Q58A65-1","NP_081845.2","C-Jun-amino-terminal kinase-interacting protein 4 isoform 1","1307",""
14332c14289
< "Q61458-1","NP_075732.1","cyclin-H isoform a","323",""
---
> "Q7TN60-1","NP_663414.3","transmembrane channel-like protein 6","810",""
14333a14291
> "Q8K596-1","NP_001334490.1","sodium/calcium exchanger 2 isoform 2 precursor","915",""
14336,14337d14293
< "Q9CZ04-1","NP_036133.1","COP9 signalosome complex subunit 7a isoform 1","275",""
< "Q04692-1","NP_031984.1","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 isoform 1","1021",""
14343a14300,14301
> "Q61699-1","NP_001334463.1","heat shock protein 105 kDa isoform 2","814",""
> "Q8K4L3-1","NP_001334378.1","supervillin isoform b","1766",""
14349,14350c14307
< "P20826-1","NP_038626.1","kit ligand isoform 1 precursor","273",""
< "Q9CQJ7-1","NP_038945.2","securin isoform 2","188",""
---
> "Q3UMF0-1","NP_081501.1","cordon-bleu protein-like 1 isoform 2","1203",""
14352d14308
< "Q8BH06-1","NP_665825.2","interleukin-17 receptor E isoform 1 precursor","637",""
14357a14314
> "Q91YM4-1","NP_001123929.1","FAST kinase domain-containing protein 4 isoform 1","630",""
14358a14316
> "P50540-1","NP_001008543.1","max-interacting protein 1 isoform c","192","This gene encodes a protein containing a helix-loop-helix domain characteristic of transcription factors, which allows heterodimerization and sequence-specific DNA binding. The encoded protein is related to a family of Myc/Max/Mad proteins that are involved in the regulation of several cellular processes. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate Myc function. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. "
14360d14317
< "Q91YM4-1","NP_598772.1","FAST kinase domain-containing protein 4 isoform 1","630",""
14378d14334
< "Q3UH68-1","NP_001243051.1","LIM and calponin homology domains-containing protein 1 isoform 2","901",""
14386d14341
< "Q60997-1","NP_031795.2","deleted in malignant brain tumors 1 protein isoform 2 precursor","1946",""
14400a14356
> "Q9JJG0-1","NP_001334566.1","transforming acidic coiled-coil-containing protein 2 isoform d","947","This gene encodes a member of the transforming, acidic coiled-coil (TACC) family of proteins. Members of this family are centrosomal proteins that interact with microtubules and tubulin. TACC proteins are thought to be involved in centrosome/mitotic spindle dynamics and gene regulation. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. "
14402d14357
< "P35545-1","NP_032016.1","40S ribosomal protein S30","133",""
14407d14361
< "Q9JJG0-1","NP_996738.2","transforming acidic coiled-coil-containing protein 2 isoform a","1146","This gene encodes a member of the transforming, acidic coiled-coil (TACC) family of proteins. Members of this family are centrosomal proteins that interact with microtubules and tubulin. TACC proteins are thought to be involved in centrosome/mitotic spindle dynamics and gene regulation. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. "
14416a14371
> "Q3UH68-1","NP_001001980.2","LIM and calponin homology domains-containing protein 1 isoform 1","1057",""
14435a14391
> "Q60997-1","NP_001334561.1","deleted in malignant brain tumors 1 protein isoform 1 precursor","1957",""
14438a14395
> "P35545-1","NP_001153711.1","40S ribosomal protein S30","133",""
14442c14399
< "Q2EG98-1","NP_853522.2","polycystic kidney disease protein 1-like 3 isoform b precursor","2151",""
---
> "Q8BVU0-1","NP_001074724.1","DISP complex protein LRCH3 isoform 1","778",""
14443a14401,14402
> "Q9CQW7-1","NP_001156860.1","cytochrome c oxidase assembly factor 8 isoform 1","194",""
> "Q9CZX0-1","NP_001240741.1","elongator complex protein 3 isoform 1","566",""
14450d14408
< "Q8BVU0-1","NP_001297603.1","DISP complex protein LRCH3 isoform 4","796",""
14460,14461d14417
< "Q3U4G0-1","NP_997147.3","protein C15orf41 homolog isoform 2","281",""
< "G5E869-1","NP_001297597.1","zinc finger protein 142 isoform 1","1843",""
14465c14421
< "Q9CQW7-1","NP_080787.1","cytochrome c oxidase assembly factor 8 isoform 2","192",""
---
> "G5E869-1","NP_084164.1","zinc finger protein 142 isoform 2","1740",""
14467c14423
< "Q3TJ91-1","NP_663413.2","LLGL scribble cell polarity complex component 2 isoform 1","1027",""
---
> "Q3U4G0-1","NP_001139370.1","protein C15orf41 homolog isoform 1","287",""
14468a14425
> "Q3TJ91-1","NP_001239461.1","LLGL scribble cell polarity complex component 2 isoform 2","1051",""
14470d14426
< "Q8CHU3-1","NP_034278.1","epsin-2 isoform 2","595",""
14472a14429
> "O70263-1","NP_001153049.1","E3 ubiquitin-protein ligase LNX isoform 1","728",""
14476a14434
> "Q80VP1-1","NP_001239383.1","epsin-1 isoform 1","575",""
14481a14440
> "Q9Z239-1","NP_062376.2","phospholemman isoform a precursor","95","This gene encodes a member of the FXYD family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity and act as an accessory protein of Na,K-ATPase. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]. "
14483,14485c14442,14443
< "P39689-1","NP_031695.1","cyclin-dependent kinase inhibitor 1","159","This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at the G1 pahse. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. "
< "Q80VP1-1","NP_034277.1","epsin-1 isoform 1","575",""
< "Q9Z239-1","NP_919302.1","phospholemman isoform b precursor","92","This gene encodes a member of the FXYD family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity and act as an accessory protein of Na,K-ATPase. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]. "
---
> "Q8CHU3-1","NP_001239118.1","epsin-2 isoform 3","583",""
> "Q8CGY8-1","NP_001277464.1","UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2","1036",""
14486a14445
> "P39689-1","NP_001104569.1","cyclin-dependent kinase inhibitor 1","159","This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at the G1 pahse. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. "
14488d14446
< "Q8CGY8-1","NP_631883.2","UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1","1046",""
14490d14447
< "O70263-1","NP_034857.3","E3 ubiquitin-protein ligase LNX isoform 2 precursor","628",""
14494c14451
< "Q61789-1","NP_034810.1","laminin subunit alpha-3 isoform 3B precursor","3330",""
---
> "Q61789-1","NP_001334390.1","laminin subunit alpha-3 isoform 3A precursor","1724",""
14504a14462
> "Q9ET47-1","NP_997570.1","espin isoform 1","871",""
14512d14469
< "P23611-1","NP_032346.1","interferon regulatory factor 8","424","The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. "
14517,14519c14474
< "Q9R1K7-1","NP_062730.1","tubulin delta chain isoform 2","455",""
< "Q3T9X0-1","NP_001012363.2","solute carrier family 2, facilitated glucose transporter member 9 isoform 2","523",""
< "P32507-1","NP_033016.3","nectin-2 isoform 1 precursor","530",""
---
> "Q921G8-1","NP_001272936.1","gamma-tubulin complex component 2 isoform a","905",""
14521c14476
< "P0CW02-1","NP_034871.2","lymphocyte antigen 6C1 isoform 1 precursor","131",""
---
> "Q99PV5-1","NP_001258697.1","class E basic helix-loop-helix protein 41 isoform 2","131","This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with Arntl or compete for E-box binding sites in the promoter of Per1 and repress Clock/Arntl's transactivation of Per1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2014]. "
14523c14478,14479
< "P14719-1","NP_034873.2","interleukin-1 receptor-like 1 isoform b precursor","337",""
---
> "P11798-1","NP_001273738.1","calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 3 precursor","189",""
> "Q64729-1","NP_001299797.1","TGF-beta receptor type-1 isoform 2 precursor","499","This gene encodes a member of the transforming growth factor beta (TGF-beta) receptor family of proteins. These proteins comprise one component of the TGF-beta signaling pathway, which transduces extracellular signals into gene expression changes to regulate a wide range of cellular responses, including proliferation, migration, differentiation and apoptosis. Homozygous knockout mice for this gene exhibit impaired angiogenesis and embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. "
14525,14527c14481
< "Q9R1M5-1","NP_035990.1","NACHT, LRR and PYD domains-containing protein 5 isoform a","1111","This gene encodes a member of the NACHT, leucine-rich repeat, and pyrin domain containing family. Members of this family have a pyrin domain at the N-terminus, a central NACHT domain, and a C-terminal leucine-rich repeat domain. This gene encodes a maternal-effect factor that is essential for early embryonic development in the mouse. Homozygous null mutant females are sterile, and embryos die following the first cleavage. This gene is required for endoplasmic reticulum redistribution and calcium homeostasis in oocytes. In addition, ovulated oocytes mutant for this gene have abnormal mitochondrial localization and increased mitochondrial activity, which results in mitochondrial damage and early embryonic lethality. Pseudogenes of this gene have been found on chromosomes 7 and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
< "Q99PJ1-1","NP_075604.2","protocadherin-15 isoform CD1-1 precursor","1943",""
< "Q8BND5-1","NP_075757.1","sulfhydryl oxidase 1 isoform b precursor","568",""
---
> "Q9D2I5-1","NP_001297631.1","lisH domain-containing protein ARMC9 isoform 3","818",""
14535c14489
< "Q61616-1","NP_034206.1","D(1A) dopamine receptor","446",""
---
> "Q80U16-1","NP_001073850.1","rho family-interacting cell polarization regulator 2 isoform 2","672",""
14537d14490
< "Q9Z101-1","NP_062669.2","partitioning defective 6 homolog alpha isoform 1","346",""
14542,14546c14495
< "P30282-1","NP_031658.1","G1/S-specific cyclin-D3","292",""
< "P11798-1","NP_803126.1","calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2","478",""
< "Q9D8F1-1","NP_082346.1","alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 isoform 2","215",""
< "Q64729-1","NP_033396.1","TGF-beta receptor type-1 isoform 1 precursor","503","This gene encodes a member of the transforming growth factor beta (TGF-beta) receptor family of proteins. These proteins comprise one component of the TGF-beta signaling pathway, which transduces extracellular signals into gene expression changes to regulate a wide range of cellular responses, including proliferation, migration, differentiation and apoptosis. Homozygous knockout mice for this gene exhibit impaired angiogenesis and embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. "
< "Q08775-1","NP_033950.2","runt-related transcription factor 2 isoform 1","528","This gene encodes a member of the runt domain-containing family of transcription factors. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Sep 2015]. "
---
> "O70176-1","NP_001302432.1","pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein","175","This gene encodes a member of the glucagon superfamily of hormones that have important roles in growth and metabolism. The encoded protein undergoes proteolytic processing to generate mature peptides that function as hypophysiotropic hormones, neurotransmitters, neuromodulators and vasoregulators. Mice lacking the encoded protein exhibit a high rate of early mortality. The surviving adult animals lacking the encoded protein exhibit decreased anxiety, hyperactive behavior and impaired steroidogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]. "
14548d14496
< "Q6PHZ2-1","NP_076302.1","calcium/calmodulin-dependent protein kinase type II subunit delta isoform 3","478",""
14551c14499
< "Q60575-1","NP_032467.2","kinesin-like protein KIF1B isoform a","1150",""
---
> "Q99PJ1-1","NP_001136207.1","protocadherin-15 isoform CD1-2 precursor","1938",""
14554d14501
< "P51125-1","NP_001288110.1","calpastatin isoform 8","446","This gene encodes an inhibitor of the calcium-dependent cysteine protease, calpain. This protein plays roles in multiple processes, including apoptosis, cell cycle regulation, and membrane fusion. Multiple protein isoforms exist which contain unique N-terminal domains, and multiple inhibitory domains that share homology with each other. Some isoforms may be tissue-specific. Two different pseudogenes of this gene are found on chromosome 19. [provided by RefSeq, Jul 2014]. "
14556a14504
> "P41438-1","NP_001186200.1","reduced folate transporter","512",""
14557a14506
> "P70274-1","NP_001036078.1","selenoprotein P precursor","380","This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in mouse), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. Alternatively spliced transcript variants differing in 5' non-coding region have been described for this gene. Expression of these variants varies in different tissues and developmental stages (PMID:23064117). [provided by RefSeq, Feb 2017]. "
14559a14509,14510
> "Q62407-1","NP_001078839.1","striated muscle-specific serine/threonine-protein kinase isoform 2","2527","This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Studies have determined that a lack of this protein affected myocardial development. Multiple alternatively spliced transcript variants that encode different protein isoforms have been defined. [provided by RefSeq, Mar 2010]. "
> "Q9R1V6-3","NP_001007221.1","disintegrin and metalloproteinase domain-containing protein 22 isoform a precursor","857","This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. The protein encoded by this gene is believed to lack metalloproteinase activity due to the lack of a critical catalytic motif. Mice lacking the encoded protein exhibit severe ataxia, hypomyelination and premature death. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]. "
14561a14513
> "Q3T9X0-1","NP_001095885.1","solute carrier family 2, facilitated glucose transporter member 9 isoform 3","431",""
14563d14514
< "O54785-1","NP_774958.1","LIM domain kinase 2 isoform b","617",""
14564a14516
> "Q61089-1","NP_001155966.1","frizzled-6 precursor","709",""
14567a14520,14521
> "Q9JLB9-1","NP_067470.1","nectin-3 isoform alpha","549",""
> "P07141-1","NP_001107001.1","macrophage colony-stimulating factor 1 isoform 2 precursor","257",""
14571c14525,14527
< "Q9DAU1-1","NP_082341.1","protein canopy homolog 3 isoform 1 precursor","276","This gene encodes a member of the canopy family of proteins. The encoded protein may play a role in the maturation of toll-like receptors. Homozygous knockout mice for this gene show reduced cell surface expression of toll-like receptors and an impaired immune response including reduced production of cytokines in a mouse model of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
---
> "P35438-1","NP_001171127.1","glutamate receptor ionotropic, NMDA 1 isoform 2","906",""
> "P04370-1","NP_001020416.1","Golli-Mbp isoform 2","195","The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called 'Golli-Mbp') that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]. "
> "Q8BSN3-1","NP_001157259.1","coiled-coil domain-containing protein 151 isoform 1","594",""
14573d14528
< "P48725-1","NP_032813.3","pericentrin isoform a","2916",""
14575d14529
< "P23204-1","NP_035274.2","peroxisome proliferator-activated receptor alpha","468",""
14577d14530
< "Q62407-1","NP_001166948.1","striated muscle-specific serine/threonine-protein kinase isoform 4","113","This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Studies have determined that a lack of this protein affected myocardial development. Multiple alternatively spliced transcript variants that encode different protein isoforms have been defined. [provided by RefSeq, Mar 2010]. "
14581d14533
< "O88809-1","NP_034155.2","neuronal migration protein doublecortin isoform c","360","This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase. Studies in knockout mice lacking this gene and the LIS1 gene suggest that the molecular interaction of these two genes is important in both in neuronal migration and neurogenesis, and there is a cortical role of this gene in nuclear translocation and positioning of the mitotic spindle in radial glial mitotic division. Multiple transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]. "
14583c14535
< "P97479-1","NP_032689.2","unconventional myosin-VIIa isoform 2","2177",""
---
> "Q9D8F1-1","NP_001334421.1","alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 isoform 1","300",""
14585d14536
< "O70176-1","NP_033755.1","pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein","175","This gene encodes a member of the glucagon superfamily of hormones that have important roles in growth and metabolism. The encoded protein undergoes proteolytic processing to generate mature peptides that function as hypophysiotropic hormones, neurotransmitters, neuromodulators and vasoregulators. Mice lacking the encoded protein exhibit a high rate of early mortality. The surviving adult animals lacking the encoded protein exhibit decreased anxiety, hyperactive behavior and impaired steroidogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]. "
14588,14589c14539
< "P70274-1","NP_033181.3","selenoprotein P precursor","380","This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in mouse), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. Alternatively spliced transcript variants differing in 5' non-coding region have been described for this gene. Expression of these variants varies in different tissues and developmental stages (PMID:23064117). [provided by RefSeq, Feb 2017]. "
< "Q61006-1","NP_035074.2","muscle, skeletal receptor tyrosine-protein kinase isoform 4","868","This gene encodes a member of the protein tyrosine kinase family. The encoded protein is a type 1 receptor-like protein located in muscle membrane that is activated by the heparan sulfate proteoglycan agrin released by nerve cells. The encoded protein activates signaling cascades responsible for multiple aspects of motor neuron and muscle development, including organization of the postsynaptic membrane, synaptic gene transcription, patterning of skeletal muscle, anchoring of acetylcholinesterase, and guidance of motor axons. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. "
---
> "Q9R1M5-1","NP_001034232.1","NACHT, LRR and PYD domains-containing protein 5 isoform b","1095","This gene encodes a member of the NACHT, leucine-rich repeat, and pyrin domain containing family. Members of this family have a pyrin domain at the N-terminus, a central NACHT domain, and a C-terminal leucine-rich repeat domain. This gene encodes a maternal-effect factor that is essential for early embryonic development in the mouse. Homozygous null mutant females are sterile, and embryos die following the first cleavage. This gene is required for endoplasmic reticulum redistribution and calcium homeostasis in oocytes. In addition, ovulated oocytes mutant for this gene have abnormal mitochondrial localization and increased mitochondrial activity, which results in mitochondrial damage and early embryonic lethality. Pseudogenes of this gene have been found on chromosomes 7 and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
14592,14593c14542,14543
< "Q9JLB9-1","NP_067472.1","nectin-3 isoform gamma","438",""
< "Q99KW3-3","NP_613045.3","TRIO and F-actin-binding protein isoform 5","1968","This gene encodes a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility, and cell growth. The encoded protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in the human gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants have been described [provided by RefSeq, Sep 2012]. "
---
> "Q62165-1","NP_001263410.1","dystroglycan preproprotein","893","This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. A complete lack of the encoded protein in mice results in embryonic lethality due to the disorganization of Reichert's membrane. Chimeric mice deficient in the encoded protein overcome embryonic lethality but develop a progressive muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015]. "
> "Q8BP22-1","NP_001297672.1","protein FAM92A isoform 2","351",""
14597d14546
< "Q8BP22-1","NP_080834.3","protein FAM92A isoform 1","355",""
14599,14600c14548,14549
< "Q61089-1","NP_032082.3","frizzled-6 precursor","709",""
< "Q501J6-1","NP_951062.1","probable ATP-dependent RNA helicase DDX17 isoform 1","652","This gene encodes the mouse homolog of human DEAD box polypeptide 17. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). RNA helicases of the DEAD-box family are involved in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. "
---
> "Q924A0-1","NP_001136390.1","transcription factor 7-like 2 isoform 1","459",""
> "Q08775-1","NP_001139510.1","runt-related transcription factor 2 isoform 1","528","This gene encodes a member of the runt domain-containing family of transcription factors. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Sep 2015]. "
14604a14554,14556
> "P63101-1","NP_001240734.1","14-3-3 protein zeta/delta isoform 1","245",""
> "Q9Z2D6-1","NP_001075448.1","methyl-CpG-binding protein 2 isoform 1","501",""
> "P97801-1","NP_001239558.1","survival motor neuron protein isoform 2","94",""
14608c14560
< "Q62418-1","NP_038838.1","drebrin-like protein isoform 2","433",""
---
> "Q5VCS6-1","NP_001128213.1","tudor domain-containing protein 5 isoform 1","1040",""
14609a14562
> "O88735-1","NP_001185564.1","ensconsin isoform 2","738",""
14611d14563
< "Q921G8-1","NP_598516.2","gamma-tubulin complex component 2 isoform a","905",""
14612a14565
> "P32507-1","NP_001153196.1","nectin-2 isoform 2 precursor","467",""
14614c14567
< "Q9Z2D6-1","NP_034918.1","methyl-CpG-binding protein 2 isoform 2","484",""
---
> "P97479-1","NP_001243010.1","unconventional myosin-VIIa isoform 1","2215",""
14616c14569
< "P07141-1","NP_031804.3","macrophage colony-stimulating factor 1 isoform 1 precursor","552",""
---
> "Q6PHZ2-1","NP_001020609.1","calcium/calmodulin-dependent protein kinase type II subunit delta isoform 2","499",""
14617a14571
> "P0CW02-1","NP_001238984.1","lymphocyte antigen 6C1 isoform 1 precursor","131",""
14620d14573
< "Q9R1V6-3","NP_001297369.1","disintegrin and metalloproteinase domain-containing protein 22 isoform 5 preproprotein","904","This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. The protein encoded by this gene is believed to lack metalloproteinase activity due to the lack of a critical catalytic motif. Mice lacking the encoded protein exhibit severe ataxia, hypomyelination and premature death. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]. "
14622a14576
> "Q9D6Y7-1","NP_001240641.1","mitochondrial peptide methionine sulfoxide reductase isoform 1","233",""
14623a14578
> "Q61006-1","NP_001032205.1","muscle, skeletal receptor tyrosine-protein kinase isoform 2","878","This gene encodes a member of the protein tyrosine kinase family. The encoded protein is a type 1 receptor-like protein located in muscle membrane that is activated by the heparan sulfate proteoglycan agrin released by nerve cells. The encoded protein activates signaling cascades responsible for multiple aspects of motor neuron and muscle development, including organization of the postsynaptic membrane, synaptic gene transcription, patterning of skeletal muscle, anchoring of acetylcholinesterase, and guidance of motor axons. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. "
14625,14626d14579
< "Q99PV5-1","NP_077789.1","class E basic helix-loop-helix protein 41 isoform 1","410","This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with Arntl or compete for E-box binding sites in the promoter of Per1 and repress Clock/Arntl's transactivation of Per1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2014]. "
< "Q9QUN5-1","NP_038794.1","prolactin-3C1 isoform 1 precursor","212",""
14629d14581
< "Q9D6Y7-1","NP_080598.2","mitochondrial peptide methionine sulfoxide reductase isoform 1","233",""
14632c14584
< "Q5VCS6-1","NP_001264659.1","tudor domain-containing protein 5 isoform 2","945",""
---
> "P70396-1","NP_034186.2","homeobox protein DLX-5 isoform 1","289",""
14633a14586
> "Q61616-1","NP_001278730.1","D(1A) dopamine receptor","446",""
14635c14588
< "Q9D2I5-1","NP_084460.1","lisH domain-containing protein ARMC9 isoform 1","817",""
---
> "Q9DAU1-1","NP_001292917.1","protein canopy homolog 3 isoform 2 precursor","167","This gene encodes a member of the canopy family of proteins. The encoded protein may play a role in the maturation of toll-like receptors. Homozygous knockout mice for this gene show reduced cell surface expression of toll-like receptors and an impaired immune response including reduced production of cytokines in a mouse model of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
14643,14645c14596,14597
< "Q3TMX7-1","NP_705787.1","sulfhydryl oxidase 2 isoform 2 precursor","639","This gene encodes a member of the sulfhydryl oxidase protein family. Members of this family catalyze formation of disulfide bonds. A similar protein in humans may sensitize neuroblastoma cells to interferon gamma-induced cell death. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]. "
< "P63101-1","NP_035870.1","14-3-3 protein zeta/delta isoform 1","245",""
< "P97801-1","NP_035550.1","survival motor neuron protein isoform 1","288",""
---
> "P16043-1","NP_001316612.1","somatoliberin preproprotein","103","This gene encodes a hormone that has stimulatory effects on pituitary growth hormone synthesis and release, and somatotrope expansion. The encoded preproprotein undergoes proteolytic processing to generate the mature peptide that is secreted by hypothalamus. Mice lacking the encoded protein are deficient in the growth hormone, live longer and exhibit growth retardation, enhanced insulin sensitivity and increased xenobiotic metabolism. [provided by RefSeq, Jul 2016]. "
> "Q6URW6-1","NP_001258467.1","myosin-14 isoform 1","2033",""
14646a14599
> "Q9R1K7-1","NP_001185976.1","tubulin delta chain isoform 2","455",""
14651,14652d14603
< "Q5SSZ7-1","NP_001277430.1","E3 ubiquitin-protein ligase ZNRF3 isoform 2","809",""
< "Q8BSN3-1","NP_084215.2","coiled-coil domain-containing protein 151 isoform 2","593",""
14654c14605,14607
< "Q6URW6-1","NP_082297.1","myosin-14 isoform 3","1992",""
---
> "Q5SSZ7-1","NP_001074393.1","E3 ubiquitin-protein ligase ZNRF3 isoform 1 precursor","913",""
> "Q60575-1","NP_001277924.1","kinesin-like protein KIF1B isoform c","1816",""
> "Q62418-1","NP_001139780.1","drebrin-like protein isoform 1","436",""
14657,14659c14610
< "Q62165-1","NP_034147.1","dystroglycan preproprotein","893","This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. A complete lack of the encoded protein in mice results in embryonic lethality due to the disorganization of Reichert's membrane. Chimeric mice deficient in the encoded protein overcome embryonic lethality but develop a progressive muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015]. "
< "Q924A0-1","NP_001136396.1","transcription factor 7-like 2 isoform 8","299",""
< "P16043-1","NP_034415.1","somatoliberin preproprotein","103","This gene encodes a hormone that has stimulatory effects on pituitary growth hormone synthesis and release, and somatotrope expansion. The encoded preproprotein undergoes proteolytic processing to generate the mature peptide that is secreted by hypothalamus. Mice lacking the encoded protein are deficient in the growth hormone, live longer and exhibit growth retardation, enhanced insulin sensitivity and increased xenobiotic metabolism. [provided by RefSeq, Jul 2016]. "
---
> "O54785-1","NP_001029202.1","LIM domain kinase 2 isoform c","451",""
14660a14612
> "P14719-1","NP_001020773.1","interleukin-1 receptor-like 1 isoform a precursor","567",""
14664d14615
< "P04370-1","NP_034907.1","Golli-Mbp isoform 1","250","The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called 'Golli-Mbp') that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]. "
14666a14618
> "Q9Z101-1","NP_001040900.1","partitioning defective 6 homolog alpha isoform 2","345",""
14668c14620,14621
< "P41438-1","NP_112473.1","reduced folate transporter","512",""
---
> "Q9QUN5-1","NP_001156690.1","prolactin-3C1 isoform 2","192",""
> "O88809-1","NP_001103692.1","neuronal migration protein doublecortin isoform a","366","This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase. Studies in knockout mice lacking this gene and the LIS1 gene suggest that the molecular interaction of these two genes is important in both in neuronal migration and neurogenesis, and there is a cortical role of this gene in nuclear translocation and positioning of the mitotic spindle in radial glial mitotic division. Multiple transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]. "
14670a14624
> "Q8BND5-1","NP_001020116.1","sulfhydryl oxidase 1 isoform a precursor","748",""
14673a14628
> "P23204-1","NP_001106889.1","peroxisome proliferator-activated receptor alpha","468",""
14675d14629
< "P35438-1","NP_032195.1","glutamate receptor ionotropic, NMDA 1 isoform 1 precursor","938",""
14677c14631
< "Q80U16-1","NP_848773.3","rho family-interacting cell polarization regulator 2 isoform 3","633",""
---
> "Q3TMX7-1","NP_001289885.1","sulfhydryl oxidase 2 isoform 1 precursor","692","This gene encodes a member of the sulfhydryl oxidase protein family. Members of this family catalyze formation of disulfide bonds. A similar protein in humans may sensitize neuroblastoma cells to interferon gamma-induced cell death. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]. "
14682d14635
< "P70396-1","NP_942151.1","homeobox protein DLX-5 isoform 2","146",""
14687c14640,14641
< "Q91WE9-1","NP_598857.1","chemokine-like protein TAFA-5 isoform 2 precursor","125","This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]. "
---
> "P30282-1","NP_001075104.1","G1/S-specific cyclin-D3","292",""
> "P23611-1","NP_001288740.1","interferon regulatory factor 8","424","The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. "
14692c14646,14647
< "Q4JK59-1","NP_001333665.1","methylcytosine dioxygenase TET2 isoform 2","1920",""
---
> "Q60641-1","NP_001156976.1","bile acid receptor isoform 2","474",""
> "P15806-1","NP_001157620.1","transcription factor E2-alpha isoform 2","652",""
14694,14695d14648
< "Q9ERB5-1","NP_067446.1","solute carrier organic anion transporter family member 1C1 isoform 1","715",""
< "P15314-1","NP_032416.1","interferon regulatory factor 1 isoform a","329",""
14697c14650,14651
< "Q9Z2D8-1","NP_038623.1","methyl-CpG-binding domain protein 3 isoform 1","285","This gene encodes a member of the MBD family of nuclear proteins that contain a methyl-CpG binding domain (MBD). The encoded protein is a component of the nucleosome remodeling and histone deacetylation (NuRD) complex. Deletion of this gene causes embryonic lethality in mice. Embryonic stem cells lacking the encoded protein are severely compromised in their ability to differentiate and fail to commit to developmental lineages in the absence of leukemia inhibitory factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. "
---
> "P62984-1","NP_001335156.1","ubiquitin-60S ribosomal protein L40 precursor","128",""
> "Q9DBY1-1","NP_001158181.1","E3 ubiquitin-protein ligase synoviolin precursor","612",""
14699a14654
> "Q9Z2D8-1","NP_001293072.1","methyl-CpG-binding domain protein 3 isoform 2","253","This gene encodes a member of the MBD family of nuclear proteins that contain a methyl-CpG binding domain (MBD). The encoded protein is a component of the nucleosome remodeling and histone deacetylation (NuRD) complex. Deletion of this gene causes embryonic lethality in mice. Embryonic stem cells lacking the encoded protein are severely compromised in their ability to differentiate and fail to commit to developmental lineages in the absence of leukemia inhibitory factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. "
14701,14702d14655
< "Q6PDQ2-1","NP_666091.1","chromodomain-helicase-DNA-binding protein 4","1915",""
< "Q60641-1","NP_001157172.1","bile acid receptor isoform 1","488",""
14705d14657
< "Q9DBY1-1","NP_083045.4","E3 ubiquitin-protein ligase synoviolin precursor","612",""
14707c14659,14661
< "P15806-1","NP_035678.3","transcription factor E2-alpha isoform 8","648",""
---
> "Q3U9N9-1","NP_001107804.1","monocarboxylate transporter 10 isoform 1","512",""
> "P15314-1","NP_001152868.1","interferon regulatory factor 1 isoform a","329",""
> "Q4JK59-1","NP_001035490.2","methylcytosine dioxygenase TET2 isoform 1","1912",""
14712c14666
< "Q8VEG6-1","NP_849185.2","CCR4-NOT transcription complex subunit 6-like isoform 2","555",""
---
> "Q8VEG6-1","NP_001272440.1","CCR4-NOT transcription complex subunit 6-like isoform 1","550",""
14713a14668
> "Q9ERB5-1","NP_001171243.1","solute carrier organic anion transporter family member 1C1 isoform 2","714",""
14718a14674
> "Q9JLV5-1","NP_001300657.1","cullin-3 isoform 2 precursor","717",""
14724,14727c14680,14682
< "Q3TQR0-1","NP_663558.1","post-GPI attachment to proteins factor 2 isoform 1","250",""
< "Q8VI63-1","NP_082584.1","MOB kinase activator 2 isoform 1","235",""
< "Q8BZJ8-1","NP_796147.2","uncharacterized protein C8orf34 homolog isoform 2","459",""
< "Q9D123-1","NP_082665.1","insulin-like growth factor-binding protein 3 receptor isoform 1 precursor","240",""
---
> "Q3TQR0-1","NP_001278287.1","post-GPI attachment to proteins factor 2 isoform 1","250",""
> "Q571F5-1","NP_001157222.1","SPRY domain-containing SOCS box protein 3 isoform 1","500",""
> "Q9D123-1","NP_081103.1","insulin-like growth factor-binding protein 3 receptor isoform 1 precursor","240",""
14730a14686,14687
> "Q8BZJ8-1","NP_001153841.1","uncharacterized protein C8orf34 homolog isoform 1","462",""
> "Q8C0Z1-1","NP_001193264.1","protein FAM234A isoform 1","555",""
14732,14733c14689
< "Q571F5-1","NP_081417.2","SPRY domain-containing SOCS box protein 3 isoform 3","389",""
< "Q8R5F8-1","NP_080422.1","epidermal growth factor receptor kinase substrate 8-like protein 1 isoform 1","716",""
---
> "Q8C2K5-1","NP_001334272.1","RAS protein activator like-3 isoform 1","1043",""
14735,14736c14691
< "Q8C0Z1-1","NP_997100.1","protein FAM234A isoform 1","555",""
< "Q8C2K5-1","NP_848900.2","RAS protein activator like-3 isoform 2","1041",""
---
> "Q8R5F8-1","NP_001277345.1","epidermal growth factor receptor kinase substrate 8-like protein 1 isoform 1","716",""
14739,14740d14693
< "Q91WK0-1","NP_082018.1","leucine-rich repeat flightless-interacting protein 2 isoform 2","400",""
< "Q9EPJ9-1","NP_665703.2","ADP-ribosylation factor GTPase-activating protein 1 isoform a","414",""
14742d14694
< "Q61147-1","NP_031778.2","ceruloplasmin isoform b precursor","1061","The protein encoded by this gene is a copper-containing glycoprotein found soluble in the serum and GPI-anchored in other tissues. It oxidizes Fe(II) to Fe(III) and is proposed to play an important role in iron homeostasis. In humans mutations of this gene cause aceruloplasminemia, which is characterized by retinal degeneration, diabetes, anemia and neurological symptoms. In mouse deficiency of this gene in combination with a deficiency of its homolog hephaestin causes retinal degeneration and serves as a pathophysiological model for aceruloplasminemia and age-related macular degeneration. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]. "
14743a14696
> "Q61147-1","NP_001263177.1","ceruloplasmin isoform c precursor","1085","The protein encoded by this gene is a copper-containing glycoprotein found soluble in the serum and GPI-anchored in other tissues. It oxidizes Fe(II) to Fe(III) and is proposed to play an important role in iron homeostasis. In humans mutations of this gene cause aceruloplasminemia, which is characterized by retinal degeneration, diabetes, anemia and neurological symptoms. In mouse deficiency of this gene in combination with a deficiency of its homolog hephaestin causes retinal degeneration and serves as a pathophysiological model for aceruloplasminemia and age-related macular degeneration. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]. "
14749a14703
> "Q91WK0-1","NP_001158310.1","leucine-rich repeat flightless-interacting protein 2 isoform 1","415",""
14752c14706,14707
< "Q769J6-1","NP_001277392.1","A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform 2 precursor","1398","This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. In certain mouse strains (C57BL/6, for example) an intracisternal A-type particle (IAP) retrotransposon sequence is located in the intron 23 that causes an alternate splicing event resulting in a shorter transcript variants encoding shorter isoforms. The encoded preproprotein undergoes proteolytic processing to generate an active enzyme that cleaves von Willebrand factor (VWF) in circulating blood. [provided by RefSeq, Jul 2016]. "
---
> "Q9EPJ9-1","NP_001171177.1","ADP-ribosylation factor GTPase-activating protein 1 isoform b","392",""
> "Q9Z0H4-1","NP_001103698.1","CUGBP Elav-like family member 2 isoform 1","526",""
14755d14709
< "Q62431-1","NP_031906.1","AT-rich interactive domain-containing protein 3A isoform a","601",""
14758,14759c14712
< "P51910-1","NP_031496.2","apolipoprotein D precursor","189","The protein encoded by this gene is a component of high-density lipoprotein (HDL), but is unique in that it shares greater structural similarity to lipocalin than to other members of the apolipoprotein family, and has a wider tissue expression pattern. The encoded protein is involved in lipid metabolism, and ablation of this gene results in defects in triglyceride metabolism. Elevated levels of this gene product have been observed in multiple tissues of Niemann-Pick disease mouse models, as well as in some tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. "
< "Q02248-1","NP_031640.1","catenin beta-1","781","This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Another key function of this protein is to mediate the canonical Wnt signaling pathway and regulate gene transcription. Without Wnt signal, cytoplasmic beta-catenin that is not associated with the cadherin complex is quickly phosphorylated at the N-terminal Ser/Thr residues by the so called degradation complex containing axin, adenomatous polyposis coli (APC), casein kinase I, and GSK3B, then ubiquitylated by beta-TrCP, and degraded by the proteasome. However, in the presence of Wnt signal, the degradation complex is disrupted and the stabilized cytoplasmic beta-catenin translocates into the nucleus, where it binds various transcription factors and, together with these factors, regulates the transcription of many downstream genes. Mutations of this gene have been linked with various types of tumors. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2009]. "
---
> "Q9Z0S3-1","NP_001159397.1","claudin-14","239","This gene encodes a member of the claudin family of tight junction proteins. The encoded protein is an integral membrane protein that may function in maintaining apical membrane polarization in tight junctions located between outer hair cells and supporting cells. Loss of function of this gene is associated with hearing problems. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]. "
14764a14718
> "P07903-1","NP_001120796.1","DNA excision repair protein ERCC-1 isoform b","245",""
14772c14726
< "P09838-2","NP_033371.2","DNA nucleotidylexotransferase isoform 1","530",""
---
> "P27814-1","NP_001153376.1","killer cell lectin-like receptor subfamily B member 1C isoform 1","271",""
14774a14729,14730
> "Q9EQZ6-1","NP_001191094.1","rap guanine nucleotide exchange factor 4 isoform 1","1011",""
> "Q9JHF5-1","NP_001129563.1","V-type proton ATPase 116 kDa subunit a","834",""
14778d14733
< "Q8CFN5-1","NP_079558.1","myocyte-specific enhancer factor 2C isoform 2","432",""
14784d14738
< "O88875-1","NP_061237.3","CD160 antigen isoform a precursor","185",""
14785a14740
> "Q8C7D2-1","NP_067424.2","protein cereblon isoform 1","444","This gene encodes a protein with a Lon protease domain, a 'regulators of G protein-signaling' (RGS)-like domain and a leucine zipper. It has been proposed to regulate the assembly and surface expression of large-conductance calcium-activated potassium channels in brain and to bind thalidomide. In humans mutation in this gene causes autosomal recessive nonsyndromic cognitive disability. In mouse deficiency of this gene serves as a model to study the molecular mechanisms governing learning and memory as they relate to intellectual disability. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]. "
14787c14742
< "Q9D504-1","NP_083478.2","ankyrin repeat domain-containing protein 7 isoform 2","279",""
---
> "O35664-1","NP_001103968.1","interferon alpha/beta receptor 2 isoform b precursor","248",""
14788a14744
> "Q9ES03-1","NP_001192014.1","T-box transcription factor TBX20 isoform c","301",""
14790,14791c14746
< "P01108-1","NP_001170825.1","myc proto-oncogene protein isoform b","439","The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]. "
< "P56546-1","NP_034110.1","C-terminal-binding protein 2 isoform 2","445",""
---
> "P40226-1","NP_001166976.1","thrombopoietin isoform 1 precursor","356","This gene encodes a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. The encoded protein is a ligand for the product of the myeloproliferative leukemia virus oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. "
14793d14747
< "P63085-1","NP_036079.1","mitogen-activated protein kinase 1","358",""
14794a14749
> "Q62151-1","NP_001258351.1","advanced glycosylation end product-specific receptor isoform b precursor","393",""
14795a14751
> "P55292-1","NP_001304294.1","desmocollin-2 isoform Dsc2a preproprotein","902","This gene encodes a member of the desmocollin protein subfamily. Desmocollins are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]. "
14798a14755
> "Q9D4D4-1","NP_001258503.1","transketolase-like protein 2","627",""
14800d14756
< "Q9JM96-1","NP_064390.1","cdc42 effector protein 4","349",""
14801a14758
> "P12960-1","NP_001153119.1","contactin-1 precursor","1020",""
14803d14759
< "O88844-1","NP_034627.3","isocitrate dehydrogenase [NADP] cytoplasmic","414",""
14805a14762
> "P08505-1","NP_001300983.1","interleukin-6 isoform 2 precursor","165","This gene encodes a member of the interleukin family of cytokines that have important functions in immune response, hematopoiesis, inflammation and the acute phase response. The ectopic overexpression of the encoded protein in mice results in excessive plasma cells in circulation, leading to death. Mice lacking the encoded protein exhibit abnormalities in hepatic acute phase response, some immune mechanisms, bone resorption in response to estrogen, liver regeneration and wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. "
14813a14771
> "Q02248-1","NP_001159374.1","catenin beta-1","781","This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Another key function of this protein is to mediate the canonical Wnt signaling pathway and regulate gene transcription. Without Wnt signal, cytoplasmic beta-catenin that is not associated with the cadherin complex is quickly phosphorylated at the N-terminal Ser/Thr residues by the so called degradation complex containing axin, adenomatous polyposis coli (APC), casein kinase I, and GSK3B, then ubiquitylated by beta-TrCP, and degraded by the proteasome. However, in the presence of Wnt signal, the degradation complex is disrupted and the stabilized cytoplasmic beta-catenin translocates into the nucleus, where it binds various transcription factors and, together with these factors, regulates the transcription of many downstream genes. Mutations of this gene have been linked with various types of tumors. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2009]. "
14814a14773
> "P09838-2","NP_001036693.1","DNA nucleotidylexotransferase isoform 2","510",""
14818d14776
< "O35892-1","NP_001300642.1","nuclear autoantigen Sp-100 isoform 3","464",""
14819a14778
> "P27889-1","NP_001278197.1","hepatocyte nuclear factor 1-beta isoform 2","532",""
14820a14780
> "P63085-1","NP_001033752.1","mitogen-activated protein kinase 1","358",""
14822a14783,14784
> "Q9ERI2-1","NP_001288159.1","ras-related protein Rab-27A","221","The protein encoded by this gene is a member of the Rab family of proteins, which is the largest family within the Ras superfamily of GTPases. This gene product is thought to regulate vesicular transport, together with its specific effectors. Mutations in this gene cause several defects, including actin-based melanosome transport defects and immunodeficiency. Mutations in the human ortholog of this gene are associated with Griscelli syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. "
> "Q8C5T4-1","NP_001334385.1","MORN repeat-containing protein 3 isoform 2","169",""
14825d14786
< "Q9ERI2-1","NP_076124.1","ras-related protein Rab-27A","221","The protein encoded by this gene is a member of the Rab family of proteins, which is the largest family within the Ras superfamily of GTPases. This gene product is thought to regulate vesicular transport, together with its specific effectors. Mutations in this gene cause several defects, including actin-based melanosome transport defects and immunodeficiency. Mutations in the human ortholog of this gene are associated with Griscelli syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. "
14827d14787
< "Q80U63-1","NP_573464.2","mitofusin-2","757",""
14836c14796,14797
< "P28229-1","NP_032148.1","gap junction gamma-1 protein","396",""
---
> "P98083-1","NP_001106802.1","SHC-transforming protein 1 isoform a","579",""
> "Q8CCG4-1","NP_001018002.1","developmental pluripotency-associated protein 4 isoform 2","244",""
14838,14839c14799
< "P27040-1","NP_031423.1","activin receptor type-2B precursor","536",""
< "Q9D4D4-1","NP_083203.2","transketolase-like protein 2","627",""
---
> "O88875-1","NP_001156968.1","CD160 antigen isoform a precursor","185",""
14843d14802
< "Q99K51-1","NP_663604.1","plastin-3 isoform 1","630",""
14845d14803
< "P40226-1","NP_033405.1","thrombopoietin isoform 1 precursor","356","This gene encodes a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. The encoded protein is a ligand for the product of the myeloproliferative leukemia virus oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. "
14848,14851c14806,14809
< "P30999-1","NP_031641.2","catenin delta-1 isoform 1","938",""
< "Q9Z2G6-1","NP_035474.1","protein sel-1 homolog 1 isoform b precursor","740",""
< "Q62151-1","NP_031451.2","advanced glycosylation end product-specific receptor isoform a precursor","402",""
< "P12960-1","NP_031753.1","contactin-1 precursor","1020",""
---
> "Q61003-1","NP_001032890.1","T-cell differentiation antigen CD6 isoform 1 precursor","626",""
> "P48193-1","NP_001122078.1","protein 4.1 isoform 2","804",""
> "Q8R420-1","NP_001034670.1","ATP-binding cassette sub-family A member 3","1704",""
> "Q8R1W2-1","NP_001074021.1","germ cell-specific gene 1 protein isoform a","368",""
14857d14814
< "Q80T23-1","NP_808372.1","synaptotagmin-like protein 5 isoform 1","753",""
14862a14820
> "Q61539-1","NP_001152972.1","steroid hormone receptor ERR2 isoform 2","438",""
14864a14823
> "Q80Y24-1","NP_001127931.1","prickle-like protein 2 isoform b","845",""
14867d14825
< "P63328-1","NP_032939.1","serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform 1","521",""
14873a14832
> "Q8VCC8-1","NP_001171281.1","rap guanine nucleotide exchange factor 3 isoform 1","926",""
14876c14835
< "O88343-1","NP_061230.2","electrogenic sodium bicarbonate cotransporter 1 isoform a","1079",""
---
> "Q9ES97-1","NP_001003933.1","reticulon-3 isoform 2","945",""
14877a14837
> "Q60954-1","NP_001180200.1","homeobox protein Meis1 isoform B","390",""
14879a14840,14841
> "Q61781-1","NP_001300886.1","keratin, type I cytoskeletal 14 isoform 3","267","This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
> "Q80U63-1","NP_001272849.1","mitofusin-2","757",""
14882,14884c14844,14845
< "Q9D9J8-1","NP_082804.1","BPI fold-containing family A member 3 isoform a precursor","239",""
< "Q8R1W2-1","NP_034482.2","germ cell-specific gene 1 protein isoform b","365",""
< "O55222-1","NP_034692.2","integrin-linked protein kinase","452",""
---
> "Q6UJB9-1","NP_083957.1","transmembrane protein 270 isoform b","209",""
> "O54864-1","NP_001277645.1","histone-lysine N-methyltransferase SUV39H1 isoform 2","413",""
14886d14846
< "Q9Z0S3-1","NP_062373.3","claudin-14","239","This gene encodes a member of the claudin family of tight junction proteins. The encoded protein is an integral membrane protein that may function in maintaining apical membrane polarization in tight junctions located between outer hair cells and supporting cells. Loss of function of this gene is associated with hearing problems. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]. "
14897d14856
< "Q9EQX0-1","NP_067463.2","appetite-regulating hormone isoform 1 preproprotein","117","This gene encodes a preproprotein that undergoes proteolytic processing to yield two bioactive peptides, ghrelin and obestatin. The hormone ghrelin plays a role in enhancing appetite and has numerous other biological functions that include stimulating the secretion of growth hormone (somatotropin) from the anterior pituitary gland. Obestatin is thought to be a hormone that functions in decreasing appetite. Mice lacking the encoded protein develop normally and exhibit no gross anatomical abnormalities. This gene encodes distinct isoforms, some or all of which may undergo similar proteolytic processing. [provided by RefSeq, Jul 2016]. "
14900d14858
< "Q9Z0H4-1","NP_034290.2","CUGBP Elav-like family member 2 isoform 6","478",""
14902d14859
< "Q61781-1","NP_058654.1","keratin, type I cytoskeletal 14 isoform 1","484","This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
14906a14864
> "P97350-1","NP_001300630.1","plakophilin-1","728",""
14908,14910c14866,14868
< "O54864-1","NP_035644.1","histone-lysine N-methyltransferase SUV39H1 isoform 1","412",""
< "Q61003-1","NP_033982.3","T-cell differentiation antigen CD6 isoform 2 precursor","665",""
< "P31266-1","NP_033061.3","recombining binding protein suppressor of hairless isoform 1","526",""
---
> "Q9JM96-1","NP_001156818.1","cdc42 effector protein 4","349",""
> "P27512-1","NP_035741.2","tumor necrosis factor receptor superfamily member 5 isoform 1 precursor","289",""
> "Q80T23-1","NP_001277657.1","synaptotagmin-like protein 5 isoform 2","731",""
14913a14872
> "O55222-1","NP_001155196.1","integrin-linked protein kinase","452",""
14914a14874
> "Q68FE2-1","NP_001003917.2","autophagy-related protein 9A isoform a","839",""
14917,14918d14876
< "Q8BVR0-1","NP_997158.1","barrier-to-autointegration factor-like protein","90",""
< "P27814-1","NP_032553.2","killer cell lectin-like receptor subfamily B member 1C isoform 2","268",""
14920a14879
> "P97454-1","NP_001157513.1","mothers against decapentaplegic homolog 5","465",""
14922d14880
< "P08505-1","NP_112445.1","interleukin-6 isoform 1 precursor","211","This gene encodes a member of the interleukin family of cytokines that have important functions in immune response, hematopoiesis, inflammation and the acute phase response. The ectopic overexpression of the encoded protein in mice results in excessive plasma cells in circulation, leading to death. Mice lacking the encoded protein exhibit abnormalities in hepatic acute phase response, some immune mechanisms, bone resorption in response to estrogen, liver regeneration and wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. "
14923a14882
> "Q8CFN5-1","NP_001334493.1","myocyte-specific enhancer factor 2C isoform 3","474",""
14930c14889,14890
< "P10711-1","NP_035671.1","transcription elongation factor A protein 1 isoform 2","301",""
---
> "Q9WVG6-1","NP_067506.2","histone-arginine methyltransferase CARM1 isoform 1","608",""
> "P56546-1","NP_001164215.1","C-terminal-binding protein 2 isoform 1","988",""
14932d14891
< "Q91ZS8-1","NP_570965.2","double-stranded RNA-specific editase 1 isoform 1","701","This gene encodes a double-stranded-RNA-specific adenosine deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. "
14934d14892
< "P56485-1","NP_031748.2","atypical chemokine receptor 3","362",""
14937c14895,14896
< "P07903-1","NP_031974.2","DNA excision repair protein ERCC-1 isoform a","298",""
---
> "P51910-1","NP_001288282.1","apolipoprotein D precursor","189","The protein encoded by this gene is a component of high-density lipoprotein (HDL), but is unique in that it shares greater structural similarity to lipocalin than to other members of the apolipoprotein family, and has a wider tissue expression pattern. The encoded protein is involved in lipid metabolism, and ablation of this gene results in defects in triglyceride metabolism. Elevated levels of this gene product have been observed in multiple tissues of Niemann-Pick disease mouse models, as well as in some tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. "
> "Q99K51-1","NP_001159925.1","plastin-3 isoform 1","630",""
14939a14899
> "Q9D504-1","NP_001161229.1","ankyrin repeat domain-containing protein 7 isoform 1","280",""
14942,14943c14902
< "Q8VCC8-1","NP_659099.2","rap guanine nucleotide exchange factor 3 isoform 2","918",""
< "Q64287-1","NP_038702.1","interferon regulatory factor 4 isoform a","450",""
---
> "Q9EQX0-1","NP_001273333.1","appetite-regulating hormone isoform 2 preproprotein","116","This gene encodes a preproprotein that undergoes proteolytic processing to yield two bioactive peptides, ghrelin and obestatin. The hormone ghrelin plays a role in enhancing appetite and has numerous other biological functions that include stimulating the secretion of growth hormone (somatotropin) from the anterior pituitary gland. Obestatin is thought to be a hormone that functions in decreasing appetite. Mice lacking the encoded protein develop normally and exhibit no gross anatomical abnormalities. This gene encodes distinct isoforms, some or all of which may undergo similar proteolytic processing. [provided by RefSeq, Jul 2016]. "
14947d14905
< "O35664-1","NP_034639.2","interferon alpha/beta receptor 2 isoform a precursor","513",""
14951d14908
< "Q9EQZ7-1","NP_444501.1","regulating synaptic membrane exocytosis protein 2 isoform c","1530",""
14953d14909
< "O70274-1","NP_033000.1","protein tyrosine phosphatase type IVA 2","167",""
14956c14912
< "P97454-1","NP_032567.1","mothers against decapentaplegic homolog 5","465",""
---
> "O70274-1","NP_001158217.1","protein tyrosine phosphatase type IVA 2","167",""
14959,14960c14915,14916
< "Q8C7D2-1","NP_780566.1","protein cereblon isoform 2","445","This gene encodes a protein with a Lon protease domain, a 'regulators of G protein-signaling' (RGS)-like domain and a leucine zipper. It has been proposed to regulate the assembly and surface expression of large-conductance calcium-activated potassium channels in brain and to bind thalidomide. In humans mutation in this gene causes autosomal recessive nonsyndromic cognitive disability. In mouse deficiency of this gene serves as a model to study the molecular mechanisms governing learning and memory as they relate to intellectual disability. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]. "
< "Q62225-1","NP_034025.1","cytokine-inducible SH2-containing protein isoform 1","257",""
---
> "Q9Z2G6-1","NP_001034178.1","protein sel-1 homolog 1 isoform a precursor","790",""
> "O88343-1","NP_001129732.1","electrogenic sodium bicarbonate cotransporter 1 isoform b","1094",""
14965a14922
> "Q9QZR5-1","NP_001129537.1","homeodomain-interacting protein kinase 2 isoform 1","1161",""
14972a14930
> "Q64287-1","NP_001334437.1","interferon regulatory factor 4 isoform b","449",""
14974d14931
< "Q8CCG4-1","NP_082886.2","developmental pluripotency-associated protein 4 isoform 1","296",""
14977a14935
> "P56485-1","NP_001258536.1","atypical chemokine receptor 3","362",""
14979d14936
< "P27512-1","NP_733805.1","tumor necrosis factor receptor superfamily member 5 isoform 4 precursor","222",""
14982d14938
< "Q9WVG6-1","NP_694781.1","histone-arginine methyltransferase CARM1 isoform 2","585",""
14988d14943
< "Q80Y24-1","NP_001127933.1","prickle-like protein 2 isoform b","845",""
14992a14948
> "P21275-1","NP_001303289.1","bone morphogenetic protein 4 preproprotein","408","This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Homozygous knockout mice die in utero, while a conditional knockout mouse exhibits defects in heart development. Transgenic mice overexpressing this gene in a neuron-specific manner exhibit a phenotype resembling the rare hereditary connective tissue disease, fibrodysplasia ossificans progressiva. [provided by RefSeq, Jul 2016]. "
14994c14950
< "Q8R316-1","NP_818774.2","HMG box-containing protein 1 isoform 2","474",""
---
> "Q62431-1","NP_001275554.1","AT-rich interactive domain-containing protein 3A isoform a","601",""
14996c14952,14954
< "Q8K4G5-1","NP_848803.3","actin-binding LIM protein 1 isoform 1","861",""
---
> "P31266-1","NP_001074396.1","recombining binding protein suppressor of hairless isoform 2","487",""
> "P0C027-1","NP_001026834.1","diphosphoinositol polyphosphate phosphohydrolase 3-alpha","164",""
> "Q8K4G5-1","NP_001096647.1","actin-binding LIM protein 1 isoform 2","701",""
15000c14958
< "P55850-1","NP_031908.3","desmocollin-3 isoform 1 preproprotein","896","This gene encodes a member of the cadherin family of proteins that mediates adhesion in desmosomes. Together with desmogleins, the encoded protein forms the transmembrane core of desmosomes, a multiprotein complex involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. Mice lacking the encoded protein exhibit a pre-implantation lethal phenotype. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2016]. "
---
> "Q769J6-1","NP_001001322.1","A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform 1 preproprotein","1426","This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. In certain mouse strains (C57BL/6, for example) an intracisternal A-type particle (IAP) retrotransposon sequence is located in the intron 23 that causes an alternate splicing event resulting in a shorter transcript variants encoding shorter isoforms. The encoded preproprotein undergoes proteolytic processing to generate an active enzyme that cleaves von Willebrand factor (VWF) in circulating blood. [provided by RefSeq, Jul 2016]. "
15002,15004c14960
< "Q9JHF5-1","NP_058617.3","V-type proton ATPase 116 kDa subunit a","834",""
< "Q61539-1","NP_036064.3","steroid hormone receptor ERR2 isoform 1","454",""
< "Q9QZR5-1","NP_034563.2","homeodomain-interacting protein kinase 2 isoform 2","1196",""
---
> "Q9QXP7-1","NP_001191058.1","complement C1q tumor necrosis factor-related protein 1 precursor","281",""
15006c14962
< "Q8C5T4-1","NP_083388.1","MORN repeat-containing protein 3 isoform 1","241",""
---
> "P63328-1","NP_001280551.1","serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform 2","511",""
15011c14967
< "P98083-1","NP_035498.2","SHC-transforming protein 1 isoform b","469",""
---
> "Q8BVR0-1","NP_001038215.1","barrier-to-autointegration factor-like protein","90",""
15014,15017c14970,14971
< "P21275-1","NP_031580.2","bone morphogenetic protein 4 preproprotein","408","This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Homozygous knockout mice die in utero, while a conditional knockout mouse exhibits defects in heart development. Transgenic mice overexpressing this gene in a neuron-specific manner exhibit a phenotype resembling the rare hereditary connective tissue disease, fibrodysplasia ossificans progressiva. [provided by RefSeq, Jul 2016]. "
< "Q9JKS4-1","NP_036048.3","LIM domain-binding protein 3 isoform a","723",""
< "Q60954-1","NP_034919.1","homeobox protein Meis1 isoform A","465",""
< "Q68FE2-1","NP_001275541.1","autophagy-related protein 9A isoform a","839",""
---
> "Q62225-1","NP_001304283.1","cytokine-inducible SH2-containing protein isoform 2","159",""
> "Q9QZS3-1","NP_001129547.1","protein numb homolog isoform 1","653","This gene encodes a conserved protein that is distributed asymmetrically during cell division in the developing embryo. The encoded protein participates in cell fate decisions by interacting with the Notch receptor. Loss of function of this gene results in severe defects in neural development and loss of viability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
15020d14973
< "Q9EQZ6-1","NP_062662.1","rap guanine nucleotide exchange factor 4 isoform 2","993",""
15022a14976
> "Q3TL44-1","NP_001157214.1","NLR family member X1","975",""
15024c14978
< "P27889-1","NP_033356.2","hepatocyte nuclear factor 1-beta isoform 1","558",""
---
> "Q91ZS8-1","NP_001020008.1","double-stranded RNA-specific editase 1 isoform 2","711","This gene encodes a double-stranded-RNA-specific adenosine deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. "
15026c14980,14981
< "Q9ES03-1","NP_919239.1","T-box transcription factor TBX20 isoform a","445",""
---
> "O35716-1","NP_001258532.1","suppressor of cytokine signaling 1","212",""
> "A2AUU0-1","NP_001103982.1","mRNA N(3)-methylcytidine methyltransferase METTL8 isoform b","312","This locus encodes a member of the methyltransferase family, and is involved in chromatin remodeling. Transcripts from this locus can be induced or inhibited by cell stretch and affect cell differentiation in the myogenic or adipogenic pathways. Multiple transcript variants encoding different isoforms have been found for this gene. Additional splice variants have been described in the literature but they meet nonsense-mediated decay (NMD) criteria and are likely to be degraded as soon as they are transcribed. [provided by RefSeq, Jul 2008]. "
15029d14983
< "P97350-1","NP_062619.1","plakophilin-1","728",""
15032,15034d14985
< "Q6UJB9-1","NP_919041.1","transmembrane protein 270 isoform a","264",""
< "Q9ES97-1","NP_444306.1","reticulon-3 isoform 4","237",""
< "Q3TL44-1","NP_848507.2","NLR family member X1","975",""
15036,15037c14987
< "Q9QXP7-1","NP_064343.1","complement C1q tumor necrosis factor-related protein 1 precursor","281",""
< "Q8K5B9-1","NP_694749.1","TGFB-induced factor homeobox 2-like, X-linked 1","231",""
---
> "Q9JKS4-1","NP_001034160.1","LIM domain-binding protein 3 isoform b","661",""
15038a14989
> "Q8R316-1","NP_694878.2","HMG box-containing protein 1 isoform 1","526",""
15040d14990
< "Q8R420-1","NP_038883.2","ATP-binding cassette sub-family A member 3","1704",""
15041a14992
> "P30999-1","NP_001078917.1","catenin delta-1 isoform 2","917",""
15043a14995
> "O88844-1","NP_001104790.1","isocitrate dehydrogenase [NADP] cytoplasmic","414",""
15044a14997,14999
> "P58681-1","NP_001277684.1","toll-like receptor 7 isoform a precursor","1050",""
> "P28033-1","NP_001274667.1","CCAAT/enhancer-binding protein beta isoform b","275",""
> "P28229-1","NP_001152854.1","gap junction gamma-1 protein","396",""
15046d15000
< "P48193-1","NP_906273.3","protein 4.1 isoform 1","858",""
15051d15004
< "P28033-1","NP_034013.1","CCAAT/enhancer-binding protein beta isoform a","296",""
15058,15061c15011,15012
< "P55292-1","NP_038533.1","desmocollin-2 isoform Dsc2b preproprotein","848","This gene encodes a member of the desmocollin protein subfamily. Desmocollins are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]. "
< "Q9QZS3-1","NP_035079.1","protein numb homolog isoform 2","604","This gene encodes a conserved protein that is distributed asymmetrically during cell division in the developing embryo. The encoded protein participates in cell fate decisions by interacting with the Notch receptor. Loss of function of this gene results in severe defects in neural development and loss of viability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
< "P58681-1","NP_573474.1","toll-like receptor 7 isoform a precursor","1050",""
< "O35716-1","NP_034026.1","suppressor of cytokine signaling 1","212",""
---
> "P10711-1","NP_001153222.1","transcription elongation factor A protein 1 isoform 3","300",""
> "Q06507-1","NP_001274109.1","cyclic AMP-dependent transcription factor ATF-4","349",""
15063,15064c15014
< "Q06507-1","NP_033846.2","cyclic AMP-dependent transcription factor ATF-4","349",""
< "A2AUU0-1","NP_663499.2","mRNA N(3)-methylcytidine methyltransferase METTL8 isoform a","388","This locus encodes a member of the methyltransferase family, and is involved in chromatin remodeling. Transcripts from this locus can be induced or inhibited by cell stretch and affect cell differentiation in the myogenic or adipogenic pathways. Multiple transcript variants encoding different isoforms have been found for this gene. Additional splice variants have been described in the literature but they meet nonsense-mediated decay (NMD) criteria and are likely to be degraded as soon as they are transcribed. [provided by RefSeq, Jul 2008]. "
---
> "P01108-1","NP_001170823.1","myc proto-oncogene protein isoform b","439","The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]. "
15066a15017
> "Q9D9J8-1","NP_001278008.1","BPI fold-containing family A member 3 isoform b precursor","232",""
15068a15020
> "O35892-1","NP_001300641.1","nuclear autoantigen Sp-100 isoform 2","482",""
15087c15039
< "Q14BK3-1","NP_082816.1","testis-expressed protein 35 isoform 1","208",""
---
> "Q14BK3-1","NP_001291988.1","testis-expressed protein 35 isoform 2","207",""
15090c15042
< "Q8BQZ5-1","NP_848671.1","cleavage and polyadenylation specificity factor subunit 4 isoform c","211",""
---
> "Q8BQZ5-1","NP_001278177.1","cleavage and polyadenylation specificity factor subunit 4 isoform a","244",""
15094d15045
< "O70348-1","NP_291091.2","decapping and exoribonuclease protein","397",""
15095a15047
> "Q9WVJ3-1","NP_061225.2","carboxypeptidase Q precursor","470",""
15103d15054
< "Q61207-1","NP_035309.3","prosaposin isoform B precursor","557","This gene encodes a multifunctional glycoprotein that plays a role in the intracellular metabolism of various sphingolipids or secreted into the plasma, milk or cerebrospinal fluid. The encoded protein undergoes proteolytic processing to generate four different polypeptides known as saposin A, B, C or D, that are required for the hydrolysis of certain sphingolipids by lysosomal hydrolases. Alternately, the encoded protein is secreted into body fluids where it exhibits neurotrophic and myelinotrophic activities. A complete lack of the encoded protein is fatal to mice either at the neonatal stage or within the first month due to severe leukodystrophy and sphingolipid accumulation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature saposins. [provided by RefSeq, Sep 2015]. "
15109d15059
< "Q9WVJ3-1","NP_788262.1","carboxypeptidase Q precursor","470",""
15112a15063
> "Q61207-1","NP_001139592.1","prosaposin isoform A precursor","554","This gene encodes a multifunctional glycoprotein that plays a role in the intracellular metabolism of various sphingolipids or secreted into the plasma, milk or cerebrospinal fluid. The encoded protein undergoes proteolytic processing to generate four different polypeptides known as saposin A, B, C or D, that are required for the hydrolysis of certain sphingolipids by lysosomal hydrolases. Alternately, the encoded protein is secreted into body fluids where it exhibits neurotrophic and myelinotrophic activities. A complete lack of the encoded protein is fatal to mice either at the neonatal stage or within the first month due to severe leukodystrophy and sphingolipid accumulation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature saposins. [provided by RefSeq, Sep 2015]. "
15117a15069
> "O70348-1","NP_001157242.1","decapping and exoribonuclease protein","397",""
15123c15075
< "Q80U62-1","NP_766203.1","run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform b","941",""
---
> "Q91VT1-1","NP_001158076.1","E3 SUMO-protein ligase NSE2 isoform 2","139",""
15126c15078
< "Q91VT1-1","NP_081022.2","E3 SUMO-protein ligase NSE2 isoform 1","247",""
---
> "Q80U62-1","NP_001186967.1","run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform a","956",""
15129a15082,15083
> "O89109-1","NP_001156982.1","intermediate conductance calcium-activated potassium channel protein 4","425",""
> "P49282-1","NP_001139633.1","natural resistance-associated macrophage protein 2 isoform 1","561",""
15130a15085
> "Q9Z0F8-1","NP_001264195.1","disintegrin and metalloproteinase domain-containing protein 17 isoform 2 precursor","846","This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero or fail to survive beyond one week of age. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]. "
15132,15133d15086
< "O89109-1","NP_032459.3","intermediate conductance calcium-activated potassium channel protein 4","425",""
< "P24610-1","NP_032807.3","paired box protein Pax-3 isoform a","479",""
15135d15087
< "Q9Z0J7-1","NP_035949.2","growth/differentiation factor 15 preproprotein","303","This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. Mice lacking a functional copy of this gene exhibit progressive loss of motor neurons, and more rapid blood clot formation. [provided by RefSeq, Aug 2016]. "
15138d15089
< "Q9Z0F8-1","NP_033745.4","disintegrin and metalloproteinase domain-containing protein 17 isoform 1 preproprotein","827","This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero or fail to survive beyond one week of age. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]. "
15141,15143c15092,15093
< "Q3TUL7-1","NP_932122.2","DDB1- and CUL4-associated factor 17 isoform b","505",""
< "Q9CPW0-1","NP_080047.1","contactin-associated protein-like 2 isoform b","108",""
< "P49282-1","NP_032758.2","natural resistance-associated macrophage protein 2 isoform 2","568",""
---
> "P63158-1","NP_001300823.1","high mobility group protein B1","215","This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]. "
> "Q9QUQ5-1","NP_001240611.1","short transient receptor potential channel 4 isoform 2","890",""
15144a15095
> "Q9CPW0-1","NP_001004357.2","contactin-associated protein-like 2 isoform a precursor","1332",""
15146c15097,15098
< "Q9QUQ5-1","NP_058680.1","short transient receptor potential channel 4 isoform 1","974",""
---
> "Q9Z0J7-1","NP_001317616.1","growth/differentiation factor 15 preproprotein","303","This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. Mice lacking a functional copy of this gene exhibit progressive loss of motor neurons, and more rapid blood clot formation. [provided by RefSeq, Aug 2016]. "
> "Q3TUL7-1","NP_001159452.1","DDB1- and CUL4-associated factor 17 isoform a","519",""
15150c15102
< "P63158-1","NP_034569.1","high mobility group protein B1","215","This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]. "
---
> "Q14BU0-1","NP_001107030.1","unique cartilage matrix-associated protein isoform b preproprotein","138","This gene encodes chondrocyte-specific, highly charged proteins that are abundantly expressed during the early stages of chondrogenesis. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Despite the implied role in calcification and ossification, mice lacking the encoded protein do not display significant defects in the skeletal development. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo a similar proteolytic processing to generate mature proteins. [provided by RefSeq, Aug 2015]. "
15153d15104
< "Q14BU0-1","NP_081030.1","unique cartilage matrix-associated protein isoform a precursor","116","This gene encodes chondrocyte-specific, highly charged proteins that are abundantly expressed during the early stages of chondrogenesis. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Despite the implied role in calcification and ossification, mice lacking the encoded protein do not display significant defects in the skeletal development. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo a similar proteolytic processing to generate mature proteins. [provided by RefSeq, Aug 2015]. "
15155a15107
> "P24610-1","NP_001152992.1","paired box protein Pax-3 isoform b","484",""
15159d15110
< "Q6NXK8-1","NP_033727.1","acid-sensing ion channel 1 isoform 1","526",""
15161,15162d15111
< "Q9JLF6-1","NP_064368.3","protein-glutamine gamma-glutamyltransferase K","815",""
< "Q75UR0-1","NP_808362.2","anoctamin-5 isoform 1","904","This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to have little anion conductance activity. Elevated levels of this protein were found in dystrophic mice. In humans, mutations of this gene are associated with with musculoskeletal disorders such as myopathies, muscular dystrophy and gnathodiaphyseal dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]. "
15166c15115
< "P17095-2","NP_057869.2","high mobility group protein HMG-I/HMG-Y isoform a","107","This locus encodes a member of the nuclear, non-histone high mobility group protein family. This architectural transcription factor binds to A-T rich DNA sequences and participates in enhanceosome formation, chromatin remodeling and regulation of transcription. This protein functions in many cellular processes, including cell growth and differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]. "
---
> "Q9JIF0-1","NP_001239405.1","protein arginine N-methyltransferase 1 isoform 2","353",""
15170c15119,15120
< "Q64373-1","NP_033873.3","bcl-2-like protein 1 isoform a","233","This gene encodes a member of the Bcl-2 family of apoptosis regulators. The encoded protein is localized to the inner and outer mitochondrial membranes and regulates the programmed cell death pathway during development and tissue homeostasis. This protein binds to voltage-dependent anion channels in the outer mitochondrial membrane to facilitate the uptake of calcium ions. Mice embryos lacking this gene survived for two weeks and exhibited cell death of immature hematopoietic cells and neurons. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jan 2014]. "
---
> "Q99P21-1","NP_001153053.1","adenine DNA glycosylase isoform a","515",""
> "Q9WTK5-1","NP_001170840.1","nuclear factor NF-kappa-B p100 subunit isoform a","899",""
15176c15126
< "P08103-1","NP_034537.2","tyrosine-protein kinase HCK isoform p59Hck","524","The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may play a role in the innate immune response and the STAT5 signaling pathway. Alternative translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization. [provided by RefSeq, Feb 2010]. "
---
> "P28649-1","NP_001335100.1","aromatase","503",""
15178c15128
< "P00184-1","NP_034122.1","cytochrome P450 1A1","524",""
---
> "Q9D2C7-1","NP_001164505.1","bax inhibitor 1","237",""
15179a15130
> "Q64373-1","NP_001276645.1","bcl-2-like protein 1 isoform a","233","This gene encodes a member of the Bcl-2 family of apoptosis regulators. The encoded protein is localized to the inner and outer mitochondrial membranes and regulates the programmed cell death pathway during development and tissue homeostasis. This protein binds to voltage-dependent anion channels in the outer mitochondrial membrane to facilitate the uptake of calcium ions. Mice embryos lacking this gene survived for two weeks and exhibited cell death of immature hematopoietic cells and neurons. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jan 2014]. "
15183d15133
< "Q924S8-1","NP_277059.1","sprouty-related, EVH1 domain-containing protein 1 isoform 1","444","This gene encodes a membrane-associated protein that is phosphorylated by tyrosine kinases in response to growth factors. The encoded protein acts as a negative regulator of the mitogen-activated protein (MAP) kinase signaling pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. "
15186a15137
> "P83741-1","NP_001171949.1","serine/threonine-protein kinase WNK1 isoform 2","2128",""
15189d15139
< "P28649-1","NP_031836.1","aromatase","503",""
15191a15142
> "O35231-1","NP_001139303.1","kinesin-like protein KIFC3 isoform b","778",""
15193d15143
< "Q9D2C7-1","NP_080945.1","bax inhibitor 1","237",""
15196c15146,15147
< "Q6NZJ6-1","NP_666053.2","eukaryotic translation initiation factor 4 gamma 1 isoform a","1600","This gene encodes a member of the eukaryotic translation initiation factors (eIF) that play important roles in translation initiation by mediating recruitment of additional initiation factors and providing a scaffold for ribosome/mRNA-bridging. Along with eIF4A and eIF4E, the encoded protein forms the eIF4F complex that bridges the 5' UTR with the polyadenylated 3' UTR resulting in mRNA circularization, enhanced translation initiation and mRNA stability. Through its association with eIF3, the encoded protein mediates recruitment of the 43S pre-initiation complex to mRNA. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes for this gene have been identified on chromosomes 2 and 13. [provided by RefSeq, Jan 2015]. "
---
> "P12657-1","NP_001106167.1","muscarinic acetylcholine receptor M1","460",""
> "P17095-2","NP_001020598.1","high mobility group protein HMG-I/HMG-Y isoform a","107","This locus encodes a member of the nuclear, non-histone high mobility group protein family. This architectural transcription factor binds to A-T rich DNA sequences and participates in enhanceosome formation, chromatin remodeling and regulation of transcription. This protein functions in many cellular processes, including cell growth and differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]. "
15200d15150
< "Q69Z98-1","NP_083702.1","serine/threonine-protein kinase BRSK2 isoform alpha","653",""
15201a15152,15153
> "Q61823-1","NP_001161963.1","programmed cell death protein 4","469",""
> "P43006-1","NP_001070982.1","excitatory amino acid transporter 2 isoform 1","572",""
15203,15204d15154
< "Q61823-1","NP_035180.2","programmed cell death protein 4","469",""
< "Q6P5F9-1","NP_598775.2","exportin-1","1071",""
15207a15158
> "Q9JLF6-1","NP_001155186.1","protein-glutamine gamma-glutamyltransferase K","815",""
15209d15159
< "Q9JIF0-1","NP_062804.1","protein arginine N-methyltransferase 1 isoform 1","371",""
15213a15164
> "Q69Z98-1","NP_001009929.1","serine/threonine-protein kinase BRSK2 isoform beta","675",""
15214a15166,15167
> "Q6P5F9-1","NP_001030303.1","exportin-1","1071",""
> "P70689-1","NP_001010937.1","gap junction beta-6 protein","261",""
15216a15170
> "P08103-1","NP_001165588.1","tyrosine-protein kinase HCK isoform p56Hck","503","The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may play a role in the innate immune response and the STAT5 signaling pathway. Alternative translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization. [provided by RefSeq, Feb 2010]. "
15219d15172
< "P70689-1","NP_001258592.1","gap junction beta-6 protein","261",""
15222,15224c15175
< "Q99P21-1","NP_573513.2","adenine DNA glycosylase isoform a","515",""
< "Q9WTK5-1","NP_062281.1","nuclear factor NF-kappa-B p100 subunit isoform a","899",""
< "P43006-1","NP_035523.1","excitatory amino acid transporter 2 isoform 3","558",""
---
> "Q9DC40-1","NP_001157133.1","telomere length regulation protein TEL2 homolog","840",""
15228c15179
< "P83741-1","NP_941992.2","serine/threonine-protein kinase WNK1 isoform 1","2377",""
---
> "P00184-1","NP_001129531.1","cytochrome P450 1A1","524",""
15229a15181
> "Q924S8-1","NP_001264185.1","sprouty-related, EVH1 domain-containing protein 1 isoform 2","229","This gene encodes a membrane-associated protein that is phosphorylated by tyrosine kinases in response to growth factors. The encoded protein acts as a negative regulator of the mitogen-activated protein (MAP) kinase signaling pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. "
15231c15183
< "P12657-1","NP_031724.2","muscarinic acetylcholine receptor M1","460",""
---
> "Q75UR0-1","NP_001258808.1","anoctamin-5 isoform 2","854","This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to have little anion conductance activity. Elevated levels of this protein were found in dystrophic mice. In humans, mutations of this gene are associated with with musculoskeletal disorders such as myopathies, muscular dystrophy and gnathodiaphyseal dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]. "
15233d15184
< "Q9DC40-1","NP_082156.2","telomere length regulation protein TEL2 homolog","840",""
15236d15186
< "O35231-1","NP_034761.3","kinesin-like protein KIFC3 isoform a","824",""
15238a15189
> "Q6NZJ6-1","NP_001291361.1","eukaryotic translation initiation factor 4 gamma 1 isoform c","1586","This gene encodes a member of the eukaryotic translation initiation factors (eIF) that play important roles in translation initiation by mediating recruitment of additional initiation factors and providing a scaffold for ribosome/mRNA-bridging. Along with eIF4A and eIF4E, the encoded protein forms the eIF4F complex that bridges the 5' UTR with the polyadenylated 3' UTR resulting in mRNA circularization, enhanced translation initiation and mRNA stability. Through its association with eIF3, the encoded protein mediates recruitment of the 43S pre-initiation complex to mRNA. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes for this gene have been identified on chromosomes 2 and 13. [provided by RefSeq, Jan 2015]. "
15243d15193
< "O35326-1","NP_033185.2","serine/arginine-rich splicing factor 5 isoform 1","269","The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Nov 2016]. "
15247,15248c15197,15198
< "Q99JY0-1","NP_663533.1","trifunctional enzyme subunit beta, mitochondrial precursor","475",""
< "Q9R0U0-1","NP_034308.1","serine/arginine-rich splicing factor 10 isoform 1","183",""
---
> "O35326-1","NP_001073162.1","serine/arginine-rich splicing factor 5 isoform 1","269","The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Nov 2016]. "
> "Q9R0U0-1","NP_001073856.1","serine/arginine-rich splicing factor 10 isoform 2","262",""
15250c15200
< "Q6PDM2-1","NP_775550.2","serine/arginine-rich splicing factor 1 isoform 1","248","The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]. "
---
> "Q6PDM2-1","NP_001071635.1","serine/arginine-rich splicing factor 1 isoform 2","201","The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]. "
15253a15204
> "Q99JY0-1","NP_001276727.1","trifunctional enzyme subunit beta, mitochondrial precursor","475",""
15258d15208
< "Q8BL97-1","NP_666195.1","serine/arginine-rich splicing factor 7 isoform 1","238","The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Five transcript variants, four of them protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]. "
15265a15216,15217
> "Q91XW8-1","NP_001264820.1","inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform 1","327","This gene is a member of the FK506-binding protein (Fkbp) family. The encoded protein plays a role in male-specific fertility and homologous pairing of chromosomes during meiosis. The protein may also be involved in LINE1 transposon silencing and binding to Hsp90 as a co-chaperone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]. "
> "P05533-1","NP_001258345.1","lymphocyte antigen 6A-2/6E-1 precursor","134",""
15269d15220
< "P12032-1","NP_035723.2","metalloproteinase inhibitor 1 isoform a precursor","205",""
15276,15277c15227
< "P51150-1","NP_033031.2","ras-related protein Rab-7a","207",""
< "Q9QUI0-1","NP_058082.2","transforming protein RhoA precursor","193","This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]. "
---
> "P42228-1","NP_001295195.1","signal transducer and activator of transcription 4","748","The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Homozygous knockout mice for this gene exhibit reduced inflammation and cytokine production in response to immune challenge. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
15281d15230
< "P50752-1","NP_035749.1","troponin T, cardiac muscle isoform f","288",""
15286d15234
< "P60202-1","NP_035253.1","myelin proteolipid protein isoform 1","277",""
15288d15235
< "Q61391-1","NP_032630.2","neprilysin","750",""
15290,15291d15236
< "Q8R3L5-1","NP_076397.2","solute carrier organic anion transporter family member 3A1 isoform 1","710",""
< "P05622-1","NP_032835.2","platelet-derived growth factor receptor beta isoform 2 precursor","1098",""
15292a15238,15240
> "O88451-1","NP_001144221.1","retinol dehydrogenase 7 precursor","316",""
> "Q9JJV9-1","NP_001240789.1","sodium channel protein type 5 subunit alpha isoform 2","2020",""
> "Q9R0H2-1","NP_001156994.1","endomucin isoform 1 precursor","261",""
15294a15243
> "Q9QUI0-1","NP_001300890.1","transforming protein RhoA precursor","193","This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]. "
15296a15246,15248
> "Q9D666-1","NP_001243044.1","SUN domain-containing protein 1 isoform 2","876",""
> "Q3TBT3-1","NP_001276520.1","stimulator of interferon genes protein isoform 2","427",""
> "P58463-1","NP_001273536.1","forkhead box protein P2 isoform 2","693",""
15299,15300d15250
< "P97377-1","NP_904326.1","cyclin-dependent kinase 2 isoform 1","346",""
< "O89110-1","NP_033942.1","caspase-8 isoform 1 precursor","480","This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis family receptors and targets downstream effectors. In mouse deficiency of this gene can cause embryonic lethality. This protein may have a role in embryogenesis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]. "
15303d15252
< "Q920A1-1","NP_598481.2","cysteinyl leukotriene receptor 2","309",""
15304a15254
> "Q9ES52-1","NP_001103662.1","phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 2","1190",""
15305a15256
> "P26618-1","NP_001076785.1","platelet-derived growth factor receptor alpha isoform 1 precursor","1089","This gene encodes a member of the receptor tyrosine kinase family of proteins. Binding of platelet-derived growth factor protein ligands to this receptor triggers receptor dimerization and autophosphorylation, resulting in the activation of several downstream signaling pathways. Signaling through the encoded receptor plays a role in gastrulation and the development of nearly all organ systems. Mice lacking a functional copy of this gene reportedly exhibit defects in lung, skeleton, testis and the central nervous system, and die soon after birth. Alternative splicing and intronic polyadenylation of gene transcripts have been implicated in muscle regeneration and fibrosis in adult mice. [provided by RefSeq, Jan 2017]. "
15307d15257
< "Q9D666-1","NP_077771.1","SUN domain-containing protein 1 isoform 1","913",""
15308a15259,15260
> "P97378-1","NP_001298070.1","interleukin-12 receptor subunit beta-2 isoform 2","540",""
> "Q9D2Y4-1","NP_001297542.1","mixed lineage kinase domain-like protein isoform 1","472","This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]. "
15311a15264
> "P12032-1","NP_001037849.1","metalloproteinase inhibitor 1 isoform a precursor","205",""
15312a15266,15267
> "Q8R3L5-1","NP_001033732.1","solute carrier organic anion transporter family member 3A1 isoform 2","692",""
> "P51150-1","NP_001280581.1","ras-related protein Rab-7a","207",""
15315d15269
< "Q60862-1","NP_032791.1","origin recognition complex subunit 2 isoform A","576",""
15317a15272
> "Q61391-1","NP_001276391.1","neprilysin","750",""
15320a15276,15277
> "P50752-1","NP_001123648.1","troponin T, cardiac muscle isoform b","301",""
> "Q99JA4-1","NP_001268788.1","cysteinyl leukotriene receptor 1 isoform a","352",""
15322c15279
< "P26618-1","NP_035188.2","platelet-derived growth factor receptor alpha isoform 1 precursor","1089","This gene encodes a member of the receptor tyrosine kinase family of proteins. Binding of platelet-derived growth factor protein ligands to this receptor triggers receptor dimerization and autophosphorylation, resulting in the activation of several downstream signaling pathways. Signaling through the encoded receptor plays a role in gastrulation and the development of nearly all organ systems. Mice lacking a functional copy of this gene reportedly exhibit defects in lung, skeleton, testis and the central nervous system, and die soon after birth. Alternative splicing and intronic polyadenylation of gene transcripts have been implicated in muscle regeneration and fibrosis in adult mice. [provided by RefSeq, Jan 2017]. "
---
> "Q5IBH7-2","NP_001136103.1","speedy protein A isoform 2","283",""
15330,15331c15287
< "Q8VCF0-1","NP_659137.1","mitochondrial antiviral-signaling protein isoform 1","503",""
< "Q8BGC0-1","NP_083647.1","HIV Tat-specific factor 1 homolog","757",""
---
> "O08858-1","NP_001177937.1","somatostatin receptor type 5","362",""
15332a15289
> "Q9JJ43-1","NP_067452.2","RNA binding protein fox-1 homolog 1 isoform gamma","396",""
15334,15336d15290
< "O88451-1","NP_059501.1","retinol dehydrogenase 7 precursor","316",""
< "Q9JJV9-1","NP_067519.2","sodium channel protein type 5 subunit alpha isoform 1","2020",""
< "Q9CRD0-1","NP_075918.1","OCIA domain-containing protein 1 isoform 1","247",""
15342,15344c15296
< "P05533-1","NP_034868.1","lymphocyte antigen 6A-2/6E-1 precursor","134",""
< "Q08481-1","NP_032842.2","platelet endothelial cell adhesion molecule isoform 1 precursor","716",""
< "P24815-1","NP_032319.1","3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1","373",""
---
> "Q60862-1","NP_001258455.1","origin recognition complex subunit 2 isoform A","576",""
15346d15297
< "Q91XW8-1","NP_291049.1","inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform 1","327","This gene is a member of the FK506-binding protein (Fkbp) family. The encoded protein plays a role in male-specific fertility and homologous pairing of chromosomes during meiosis. The protein may also be involved in LINE1 transposon silencing and binding to Hsp90 as a co-chaperone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]. "
15349d15299
< "Q99JA4-1","NP_067451.2","cysteinyl leukotriene receptor 1 isoform a","352",""
15351,15357c15301,15302
< "Q8K4J6-1","NP_694629.2","myocardin-related transcription factor A isoform 1","964",""
< "Q62011-1","NP_034459.2","podoplanin isoform 1 precursor","172",""
< "Q9R0H2-1","NP_058581.2","endomucin isoform 2 precursor","248",""
< "Q9ES52-1","NP_034696.2","phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 1","1191",""
< "P05532-1","NP_066922.2","mast/stem cell growth factor receptor Kit isoform 2 precursor","975","The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. "
< "P42228-1","NP_035617.1","signal transducer and activator of transcription 4","748","The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Homozygous knockout mice for this gene exhibit reduced inflammation and cytokine production in response to immune challenge. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
< "Q9JJ43-1","NP_899011.2","RNA binding protein fox-1 homolog 1 isoform alpha","417",""
---
> "P63157-1","NP_001157658.1","barH-like 1 homeobox protein isoform a","327",""
> "P60202-1","NP_001277490.1","myelin proteolipid protein isoform 2","242",""
15359,15360c15304,15307
< "Q8BZQ2-1","NP_084485.1","cysteine-rich secretory protein LCCL domain-containing 2 isoform 2 precursor","494",""
< "P47931-1","NP_032072.1","follistatin isoform 2 precursor","343","The protein encoded by this gene binds to and negatively regulates activin, as well as other members of the transforming growth factor beta family, and acts to prevent uncontrolled cellular proliferation. This protein also contains a heparin-binding sequence. It is expressed in many of the tissues in which activin is synthesized and is thought to clear activin from the circulation by attachment to the cell surface. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms, including FST315 and FST288, that differ at their C-terminus. Another isoform, FST303 is thought to be produced by proteolytic cleavage of FST315. These isoforms differ in their localization and in their ability to bind heparin. While FST315 is a circulating protein, FST288 is tissue-bound, and FST303 is gonad-specific. While deletion of all isoforms results in embryonic lethality, expression of just FST288 is sufficient for embryonic development, but the resultant mice have fertility defects. [provided by RefSeq, Aug 2014]. "
---
> "Q08481-1","NP_001027550.1","platelet endothelial cell adhesion molecule isoform 2 precursor","697",""
> "P16858-1","NP_001276655.1","glyceraldehyde-3-phosphate dehydrogenase isoform 1","359","This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein was originally identified as a key glycolytic enzyme that converts D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Subsequent studies have assigned a variety of additional functions to the protein including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Alternative splicing results in multiple transcript variants. Many pseudogenes similar to this locus are found throughout the mouse genome. [provided by RefSeq, Jan 2014]. "
> "Q8BGC0-1","NP_082518.1","HIV Tat-specific factor 1 homolog","757",""
> "P05532-1","NP_001116205.1","mast/stem cell growth factor receptor Kit isoform 1 precursor","979","The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. "
15361a15309
> "P05622-1","NP_001139740.1","platelet-derived growth factor receptor beta isoform 1 precursor","1099",""
15364,15365c15312,15315
< "Q3TBT3-1","NP_082537.1","stimulator of interferon genes protein isoform 1","378",""
< "P28481-3","NP_112440.2","collagen alpha-1(II) chain isoform 1 preproprotein","1487","This gene encodes the alpha-1 subunit of the fibril-forming type II collagen, the major component of cartilage and the vitreous humor of the eye. The encoded preproprotein forms homotrimeric, triple helical procollagen that undergoes proteolytic processing during fibirl formation. Mice harboring certain mutations in this gene exhibit severe chondrodysplasia characterized by short limbs and trunch, craniofacial deformities and cleft palate. A complete lack of the encoded protein in mice results in postnatal lethality. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Dec 2015]. "
---
> "P24815-1","NP_001291729.1","3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1","373",""
> "Q9CRD0-1","NP_001153359.1","OCIA domain-containing protein 1 isoform 2","196",""
> "Q920A1-1","NP_001155884.1","cysteinyl leukotriene receptor 2","309",""
> "O35864-1","NP_001264030.1","COP9 signalosome complex subunit 5 isoform 2","317",""
15367d15316
< "P58463-1","NP_997600.1","forkhead box protein P2 isoform 1","714",""
15369c15318
< "Q9WUZ5-1","NP_067442.1","troponin I, slow skeletal muscle","187",""
---
> "P97377-1","NP_058036.1","cyclin-dependent kinase 2 isoform 2","298",""
15371d15319
< "Q5IBH7-2","NP_083530.1","speedy protein A isoform 1","310",""
15373c15321
< "Q9D2Y4-1","NP_083281.1","mixed lineage kinase domain-like protein isoform 2","464","This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]. "
---
> "O89110-1","NP_001073595.1","caspase-8 isoform 1 precursor","480","This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis family receptors and targets downstream effectors. In mouse deficiency of this gene can cause embryonic lethality. This protein may have a role in embryogenesis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]. "
15375d15322
< "P63157-1","NP_062319.1","barH-like 1 homeobox protein isoform a","327",""
15377a15325
> "P28481-3","NP_001106987.2","collagen alpha-1(II) chain isoform 2 precursor","1419","This gene encodes the alpha-1 subunit of the fibril-forming type II collagen, the major component of cartilage and the vitreous humor of the eye. The encoded preproprotein forms homotrimeric, triple helical procollagen that undergoes proteolytic processing during fibirl formation. Mice harboring certain mutations in this gene exhibit severe chondrodysplasia characterized by short limbs and trunch, craniofacial deformities and cleft palate. A complete lack of the encoded protein in mice results in postnatal lethality. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Dec 2015]. "
15378a15327
> "Q8BZQ2-1","NP_001297564.1","cysteine-rich secretory protein LCCL domain-containing 2 isoform 1 precursor","495",""
15383a15333
> "Q62011-1","NP_001277751.1","podoplanin isoform 2 precursor","159",""
15385,15386c15335,15336
< "O08858-1","NP_035555.1","somatostatin receptor type 5","362",""
< "O35864-1","NP_038743.1","COP9 signalosome complex subunit 5 isoform 1","334",""
---
> "Q9WUZ5-1","NP_001106173.1","troponin I, slow skeletal muscle","187",""
> "Q8VCF0-1","NP_001193314.1","mitochondrial antiviral-signaling protein isoform 1","503",""
15388d15337
< "Q80YA9-1","NP_808419.1","connector enhancer of kinase suppressor of ras 2 isoform 1","1032",""
15395d15343
< "Q8R3Y5-1","NP_780316.3","uncharacterized protein C19orf47 homolog isoform 1","413",""
15397c15345
< "Q9R002-1","NP_036070.2","interferon-activable protein 202","445",""
---
> "Q9R002-1","NP_032353.2","interferon-activable protein 202","445",""
15401a15350
> "Q3UHI0-1","NP_001334431.1","serine-rich coiled-coil domain-containing protein 2 isoform 3","1038",""
15402a15352
> "Q9JM13-1","NP_001185988.1","rab5 GDP/GTP exchange factor isoform a","491",""
15404a15355
> "Q9DC63-1","NP_065618.1","F-box only protein 3 isoform 2","415",""
15410d15360
< "Q9WU00-1","NP_035068.3","nuclear respiratory factor 1 isoform a","503",""
15412,15413d15361
< "A2APB8-1","NP_082385.3","targeting protein for Xklp2","745",""
< "Q9CZP5-1","NP_080060.1","mitochondrial chaperone BCS1","418","The protein encoded by this gene is a chaperone protein that is involved in the assembly of complex III (CIII), one of the five protein complexes of the mitochondrial respiratory chain, and is necessary for the insertion of the Rieske iron-sulfur (RISP) and Qcr10p proteins into the precomplex. Studies from the yeast ortholog of this protein indicate that it is targeted to the inner membrane of the mitochondria, despite the absence of an N-terminal targeting sequence. Positively charged amino acids located C-terminal to the transmembrane domain are thought to act as an internal targeting signal (PMID:8599931). Mutations in the human ortholog of this gene have been associated with GRACILE syndrome, characterized by Growth retardation, Amino aciduria, Cholestasis, Iron overload, Lactic acidosis, and Early death. Mouse models with the corresponding mutation mimic the phenotype of GRACILE syndrome and display decreased complex III activity and decreased electron transport capacity (PMID:21274865). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]. "
15419c15367
< "Q9CR75-1","NP_038777.2","tumor necrosis factor receptor superfamily member 12A isoform 1 precursor","129",""
---
> "Q9JMG4-1","NP_001135405.1","sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 2 precursor","181",""
15420a15369
> "Q6IMH0-1","NP_082808.1","testis, prostate and placenta-expressed protein isoform 2","104",""
15424c15373
< "Q148V8-1","NP_598848.2","protein FAM83H","1209",""
---
> "P35412-1","NP_001010941.1","G-protein coupled receptor 12 isoform a","334",""
15426a15376
> "Q9CZP5-1","NP_001292581.1","mitochondrial chaperone BCS1","418","The protein encoded by this gene is a chaperone protein that is involved in the assembly of complex III (CIII), one of the five protein complexes of the mitochondrial respiratory chain, and is necessary for the insertion of the Rieske iron-sulfur (RISP) and Qcr10p proteins into the precomplex. Studies from the yeast ortholog of this protein indicate that it is targeted to the inner membrane of the mitochondria, despite the absence of an N-terminal targeting sequence. Positively charged amino acids located C-terminal to the transmembrane domain are thought to act as an internal targeting signal (PMID:8599931). Mutations in the human ortholog of this gene have been associated with GRACILE syndrome, characterized by Growth retardation, Amino aciduria, Cholestasis, Iron overload, Lactic acidosis, and Early death. Mouse models with the corresponding mutation mimic the phenotype of GRACILE syndrome and display decreased complex III activity and decreased electron transport capacity (PMID:21274865). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]. "
15429,15430d15378
< "P00687-1","NP_031472.2","alpha-amylase 1 precursor","511",""
< "P62900-1","NP_444487.1","60S ribosomal protein L31","125",""
15432d15379
< "Q8K3R3-1","NP_683739.2","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform 2","807",""
15436d15382
< "Q8C4X1-1","NP_057874.2","centromere protein X isoform 1","78",""
15441a15388
> "Q5RJH6-1","NP_001005507.1","protein SMG7 isoform 3","1134",""
15443d15389
< "Q5SS00-1","NP_082949.1","DBF4-type zinc finger-containing protein 2 homolog isoform 1","2493",""
15444a15391
> "Q148V8-1","NP_001161725.1","protein FAM83H","1209",""
15447d15393
< "P04247-1","NP_038621.2","myoglobin","154",""
15449a15396,15398
> "Q9WU00-1","NP_001157698.1","nuclear respiratory factor 1 isoform a","503",""
> "Q8VDH1-1","NP_001333517.1","F-box only protein 21 isoform 2","620",""
> "Q7TS63-1","NP_001139360.1","zinc finger protein ZFAT isoform 1","1237",""
15450a15400
> "Q9ET39-1","NP_001334115.1","SLAM family member 6 isoform 2 precursor","351",""
15455d15404
< "P60603-1","NP_080222.1","reactive oxygen species modulator 1","79",""
15460,15461c15409,15410
< "Q9CRC8-1","NP_077156.2","leucine-rich repeat-containing protein 40 isoform a","602",""
< "Q91W10-1","NP_080504.3","zinc transporter ZIP8 precursor","462",""
---
> "Q9R1E6-1","NP_001129549.1","ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 1","914","This gene encodes a member of the phosphodiesterase and nucleotide pyrophosphatase family of bifunctional enzymes that hydrolize phosphodiester bonds of various nucleotides. The encoded protein undergoes proteolytic processing to generate a mature protein with lysophospholipase D activity, catalyzing the cleavage of the choline group from lysophosphatidylcholine to produce lysophosphatidic acid. This gene is expressed in numerous tissues and participates in neural development, obesity, inflammation and oncogenesis. A complete lack of the encoded protein in mice results in aberrant vascular and neuronal development leading to embryonic lethality. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2015]. "
> "Q91W10-1","NP_001128621.1","zinc transporter ZIP8 precursor","462",""
15463d15411
< "Q61599-1","NP_031512.1","rho GDP-dissociation inhibitor 2 isoform 1","200","The protein encoded by this gene is a member of the Rho guanine nucleotide dissociation inhibitor (GDI) family. This gene is expressed at high levels in hematopoietic cells. This protein is cytosolic, and dissociation of Rho from this protein is required for membrane association and activation of Rho by Guanine Nucleotide Exchange Factors (GEFs). C-terminal truncations of this gene product have been reported to promote metastasis. Multiple transcript variants and protein isoforms exist. [provided by RefSeq, Aug 2014]. "
15465d15412
< "Q7TNL3-1","NP_083076.3","serine/threonine-protein kinase 40 isoform b","435",""
15467,15468c15414
< "Q8BGT1-1","NP_848469.1","leucine-rich repeat transmembrane protein FLRT3 precursor","649",""
< "Q80T91-1","NP_766110.3","multiple epidermal growth factor-like domains protein 11 isoform 2 precursor","947",""
---
> "Q9D738-1","NP_001300672.1","ankyrin repeat and SOCS box protein 12","308",""
15471c15417,15419
< "Q5SVR0-1","NP_084021.2","TBC1 domain family member 9B isoform 3","1246",""
---
> "Q921D4-1","NP_001334313.1","mediator of RNA polymerase II transcription subunit 6 isoform 1","246",""
> "Q99PM3-1","NP_113568.2","transcription initiation factor IIA subunit 1 isoform 1","378",""
> "Q99J31-1","NP_001300683.1","oligophrenin-1 isoform a","802",""
15473d15420
< "Q4VBE4-1","NP_848863.1","pikachurin isoform 2 precursor","1009",""
15476a15424,15425
> "P59900-1","NP_001278074.1","EMILIN-3 isoform b precursor","711",""
> "P62900-1","NP_001239147.1","60S ribosomal protein L31","125",""
15478,15479c15427
< "Q99LX8-1","NP_077780.3","dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4","37",""
< "Q60739-1","NP_033866.4","BAG family molecular chaperone regulator 1 isoform 1L","355","The oncogene Bcl2 encodes a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to Bcl2 protein and is referred to as Bcl2-associated athanogene. It enhances the anti-apoptotic effects of Bcl2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least two protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) start site and an alternative, downstream, AUG translation initiation site. [provided by RefSeq, Jul 2008]. "
---
> "Q4VBE4-1","NP_001276425.1","pikachurin isoform 1 precursor","1017",""
15482d15429
< "Q9R1R0-1","NP_032526.2","LIM/homeobox protein Lhx6 isoform 1","392",""
15484a15432
> "Q9CR75-1","NP_001155218.1","tumor necrosis factor receptor superfamily member 12A isoform 2 precursor","94",""
15490d15437
< "Q9DBR4-1","NP_033816.1","amyloid-beta A4 precursor protein-binding family B member 2 isoform 1","760",""
15494,15495d15440
< "Q3U2P1-1","NP_780464.2","protein transport protein Sec24A isoform 1","1090",""
< "Q8CHP5-1","NP_084376.2","partner of Y14 and mago isoform 1","203",""
15497d15441
< "Q8BMN3-1","NP_775304.1","neuronal acetylcholine receptor subunit beta-3 isoform 1 precursor","464",""
15498a15443
> "Q7TNU6-1","NP_001161748.1","zinc finger protein 250","535",""
15500d15444
< "Q8VDH1-1","NP_663539.1","F-box only protein 21 isoform 1","627",""
15503a15448
> "Q3USW5-1","NP_001017983.2","FAD-dependent oxidoreductase domain-containing protein 2 precursor","665",""
15505d15449
< "Q3USW5-1","NP_001161732.1","FAD-dependent oxidoreductase domain-containing protein 2 precursor","665",""
15506a15451,15452
> "O35640-1","NP_001268774.1","annexin A8 isoform 2","301",""
> "Q8CCS2-1","NP_001334056.1","transmembrane protein FAM155A isoform 2","378",""
15514c15460
< "Q3UEB3-1","NP_598452.2","poly(U)-binding-splicing factor PUF60 isoform b","547",""
---
> "P13808-1","NP_001240821.1","anion exchange protein 2","1237",""
15515a15462
> "A2APB8-1","NP_001135447.1","targeting protein for Xklp2","745",""
15517d15463
< "P16858-1","NP_032110.1","glyceraldehyde-3-phosphate dehydrogenase isoform 2","333","This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein was originally identified as a key glycolytic enzyme that converts D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Subsequent studies have assigned a variety of additional functions to the protein including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Alternative splicing results in multiple transcript variants. Many pseudogenes similar to this locus are found throughout the mouse genome. [provided by RefSeq, Jan 2014]. "
15518a15465,15466
> "Q6PGH1-1","NP_001008705.1","protein BUD31 homolog isoform 2","103",""
> "Q3UZ01-1","NP_001033785.1","RNA-binding region-containing protein 3 isoform a","514",""
15522d15469
< "Q9EQ15-1","NP_075609.2","guanine nucleotide-binding protein subunit beta-like protein 1 isoform 1","326",""
15525c15472
< "Q9D738-1","NP_543134.1","ankyrin repeat and SOCS box protein 12","308",""
---
> "Q99LT0-1","NP_001139694.1","protein dpy-30 homolog","99",""
15527a15475,15478
> "P70353-1","NP_001041633.1","nuclear transcription factor Y subunit gamma isoform 1","335",""
> "Q9CRC8-1","NP_001276453.1","leucine-rich repeat-containing protein 40 isoform b","384",""
> "Q61599-1","NP_001288230.1","rho GDP-dissociation inhibitor 2 isoform 1","200","The protein encoded by this gene is a member of the Rho guanine nucleotide dissociation inhibitor (GDI) family. This gene is expressed at high levels in hematopoietic cells. This protein is cytosolic, and dissociation of Rho from this protein is required for membrane association and activation of Rho by Guanine Nucleotide Exchange Factors (GEFs). C-terminal truncations of this gene product have been reported to promote metastasis. Multiple transcript variants and protein isoforms exist. [provided by RefSeq, Aug 2014]. "
> "P60603-1","NP_001157688.1","reactive oxygen species modulator 1","79",""
15529,15530c15480
< "Q9JI90-1","NP_064396.2","E3 ubiquitin-protein ligase RNF14 isoform a","485",""
< "Q91XM9-1","NP_035937.2","disks large homolog 2 isoform 1","852",""
---
> "O35465-1","NP_001104536.1","peptidyl-prolyl cis-trans isomerase FKBP8 isoform a","403",""
15533d15482
< "O35640-1","NP_038501.2","annexin A8 isoform 1","327",""
15536,15538d15484
< "Q66JX5-1","NP_957682.1","FGFR1 oncogene partner isoform 2","379",""
< "Q8CI59-1","NP_573449.2","metalloreductase STEAP3","488",""
< "Q9CZP7-1","NP_080226.1","hsp90 co-chaperone Cdc37-like 1 isoform 1","335","This gene encodes a protein related to the Hsp90 co-chaperone Cdc37. This protein may have a role in mediating interactions between the Hsp90 complex and other proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. "
15541a15488
> "Q91VD9-1","NP_001153510.1","NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor","727",""
15543a15491
> "Q8K3R3-1","NP_001074925.1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform 1","775",""
15545d15492
< "Q9Z248-1","NP_848918.1","zinc finger protein AEBP2 isoform 2","274",""
15549a15497,15500
> "Q9R1R0-1","NP_001076595.1","LIM/homeobox protein Lhx6 isoform 3","363",""
> "P19258-1","NP_001281253.1","protein Mpv17 isoform 1","176",""
> "Q8BGT1-1","NP_001165631.1","leucine-rich repeat transmembrane protein FLRT3 precursor","649",""
> "Q80XC2-1","NP_001093262.1","tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A","290",""
15555c15506
< "Q3UHU5-1","NP_766551.3","microtubule cross-linking factor 1 isoform 2","1945",""
---
> "Q9DBQ7-1","NP_001272931.1","protein-associating with the carboxyl-terminal domain of ezrin isoform 2","722",""
15557c15508
< "Q3UTH8-1","NP_001277314.1","rho guanine nucleotide exchange factor 9 isoform b","495",""
---
> "Q922W5-1","NP_001335151.1","pyrroline-5-carboxylate reductase 1, mitochondrial","309",""
15560a15512,15514
> "Q7TN98-1","NP_001277607.1","cytoplasmic polyadenylation element-binding protein 4 isoform 3","704",""
> "Q8BGS3-1","NP_084145.1","zinc finger protein with KRAB and SCAN domains 1 isoform 2","488",""
> "Q8K0B2-1","NP_001297412.1","probable lysosomal cobalamin transporter isoform 2","467",""
15566a15521
> "P23188-1","NP_001074923.1","furin preproprotein","793","This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation during which an N-terminal propeptide is cleaved to generate the mature protein. Mice lacking the encoded protein die at an embryonic stage and display hemodynamic insufficiency, cardiac ventral closure defect, axial rotation defect and abnormal yolk sac vasculature. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]. "
15568,15569c15523
< "Q7TNU6-1","NP_766405.2","zinc finger protein 250","535",""
< "Q80XQ8-1","NP_778162.1","myelin-associated neurite-outgrowth inhibitor isoform 3","194",""
---
> "Q7JJ13-1","NP_001191902.1","bromodomain-containing protein 2","798",""
15576,15577d15529
< "Q9D6M3-1","NP_080922.1","mitochondrial glutamate carrier 1 isoform a","323",""
< "P35412-1","NP_032177.1","G-protein coupled receptor 12 isoform a","334",""
15578a15531
> "Q6P1H6-1","NP_001240743.1","ankyrin repeat and LEM domain-containing protein 2 isoform 1","964",""
15587d15539
< "Q6P9Y7-1","NP_808557.2","zinc finger protein 82 isoform 1","530",""
15589d15540
< "Q9Z139-1","NP_038873.2","inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 1 precursor","937","This gene encodes a receptor tyrosine kinase that has been implicated in nervous system development, specifically in the maintenance of neural progenitor cell fate, neurite extension and synapse formation. The encoded protein, likely a pseudokinase that lacks catalytic activity, may also regulate adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. "
15591d15541
< "Q7TNH6-1","NP_766048.1","nephrocystin-3 isoform b","462",""
15592a15543
> "Q0VBD2-1","NP_001292188.1","protein MCM10 homolog","885",""
15594d15544
< "Q6PGH1-1","NP_001297700.1","protein BUD31 homolog isoform 1","144",""
15598d15547
< "Q91ZT5-1","NP_631978.1","FYVE, RhoGEF and PH domain-containing protein 4 isoform alpha","766","This gene is a member of the FYVE, RhoGEF and PH domain containing (FGD) family. The encoded protein is a Cdc42-specific guanine nucleotide exchange factor (GEF) that plays an essential role in regulating the actin cytoskeleton and cell morphology. Disruption of the gene in mouse causes abnormal nerve development and dysmyelination. Mutations in a similar gene in human can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. "
15601c15550
< "Q499E5-1","NP_780371.3","storkhead-box protein 2 isoform 2","801",""
---
> "Q6P7W0-1","NP_001298039.1","sentrin-specific protease 6 isoform 1","1139",""
15603d15551
< "Q99LT0-1","NP_077746.3","protein dpy-30 homolog","99",""
15610,15611d15557
< "Q3UZ01-1","NP_080319.2","RNA-binding region-containing protein 3 isoform a","514",""
< "Q8BR27-1","NP_766279.1","protein FAM214B","538",""
15614d15559
< "B2RPY5-1","NP_001297359.1","G-protein coupled receptor 161 isoform 3","528",""
15616a15562,15563
> "Q8BMN3-1","NP_081730.1","neuronal acetylcholine receptor subunit beta-3 isoform 2 precursor","449",""
> "Q5SUE8-1","NP_082075.2","ankyrin repeat domain-containing protein 40 isoform 1","363",""
15617a15565
> "Q8VEE0-1","NP_001297571.1","ribulose-phosphate 3-epimerase isoform 1","235",""
15619d15566
< "Q7TN98-1","NP_080528.2","cytoplasmic polyadenylation element-binding protein 4 isoform 1","729",""
15624c15571
< "Q0VBD2-1","NP_081566.2","protein MCM10 homolog","885",""
---
> "Q8K214-1","NP_001153102.1","polycomb protein SCMH1 isoform 2","706",""
15628a15576
> "Q7TNL3-1","NP_001139299.1","serine/threonine-protein kinase 40 isoform a","449",""
15631d15578
< "Q6PDS3-1","NP_766383.2","sterile alpha and TIR motif-containing protein 1 isoform 2","724",""
15632a15580
> "Q9EQ15-1","NP_001075151.1","guanine nucleotide-binding protein subunit beta-like protein 1 isoform 1","326",""
15634c15582
< "Q91VC9-1","NP_510963.1","growth hormone-inducible transmembrane protein","346",""
---
> "Q9JMH3-1","NP_001153635.1","sialidase-2 isoform 1","393",""
15636d15583
< "P13808-1","NP_033233.2","anion exchange protein 2","1237",""
15639d15585
< "Q9D842-1","NP_077213.2","aprataxin and PNK-like factor isoform 2","478",""
15641a15588
> "Q9JI90-1","NP_001158093.1","E3 ubiquitin-protein ligase RNF14 isoform a","485",""
15643,15644d15589
< "Q9JMH3-1","NP_056565.1","sialidase-2 isoform 4","379",""
< "O35465-1","NP_034353.2","peptidyl-prolyl cis-trans isomerase FKBP8 isoform b","402",""
15646d15590
< "Q6A058-1","NP_080415.3","armadillo repeat-containing X-linked protein 2","784",""
15648a15593
> "Q60739-1","NP_001165210.1","BAG family molecular chaperone regulator 1 isoform 1S","219","The oncogene Bcl2 encodes a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to Bcl2 protein and is referred to as Bcl2-associated athanogene. It enhances the anti-apoptotic effects of Bcl2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least two protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) start site and an alternative, downstream, AUG translation initiation site. [provided by RefSeq, Jul 2008]. "
15653d15597
< "P19258-1","NP_032648.1","protein Mpv17 isoform 1","176",""
15656c15600,15601
< "Q6IMH0-1","NP_955534.1","testis, prostate and placenta-expressed protein isoform 1","216",""
---
> "Q8BYW1-1","NP_001032816.1","rho GTPase-activating protein 25 isoform a","648",""
> "Q33DR3-1","NP_001161761.1","decaprenyl-diphosphate synthase subunit 2 isoform 2","352",""
15658a15604
> "Q91XM9-1","NP_001229976.1","disks large homolog 2 isoform 3","334",""
15659a15606
> "Q9CYR0-1","NP_082634.1","single-stranded DNA-binding protein, mitochondrial isoform 2","152",""
15664,15666d15610
< "Q8BGE4-1","NP_848797.1","sushi domain-containing protein 6 isoform 2 precursor","302",""
< "Q99LE6-1","NP_038881.1","ATP-binding cassette sub-family F member 2 isoform 1","628",""
< "Q8BYW1-1","NP_780685.2","rho GTPase-activating protein 25 isoform b","622",""
15667a15612
> "Q14B70-1","NP_001074018.1","highly divergent homeobox isoform 1","692",""
15670a15616
> "Q6PDS3-1","NP_001161993.1","sterile alpha and TIR motif-containing protein 1 isoform 1","764",""
15672a15619,15620
> "Q99LX8-1","NP_001128164.1","dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4","37",""
> "Q6P9Y7-1","NP_001239448.1","zinc finger protein 82 isoform 2","500",""
15676a15625
> "P43029-1","NP_001299805.1","growth/differentiation factor 7 isoform 1 preproprotein","461","This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. Mice lacking a functional copy of this gene exhibit absence of some spinal dopaminergic neurons and brain defects, male sterility, and premature death. [provided by RefSeq, Sep 2016]. "
15677a15627,15628
> "Q96DY5-1","NP_001277953.1","RING finger protein 112 isoform 2","631",""
> "Q99LE6-1","NP_001177372.1","ATP-binding cassette sub-family F member 2 isoform 2","627",""
15683d15633
< "Q9JMG4-1","NP_067401.3","sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 1 precursor","208",""
15686d15635
< "Q9JHR9-1","NP_068363.2","nuclear receptor-interacting protein 2 isoform 2","229",""
15687a15637
> "Q6A058-1","NP_001159869.1","armadillo repeat-containing X-linked protein 2","784",""
15688a15639
> "Q5SS00-1","NP_001254801.1","DBF4-type zinc finger-containing protein 2 homolog isoform 1","2493",""
15691d15641
< "Q99J31-1","NP_443208.1","oligophrenin-1 isoform a","802",""
15694d15643
< "Q14B71-1","NP_780593.3","cell division cycle-associated protein 2","982",""
15699d15647
< "Q8VEE0-1","NP_079959.2","ribulose-phosphate 3-epimerase isoform 2","228",""
15700a15649
> "P59384-1","NP_001019310.1","A disintegrin and metalloproteinase with thrombospondin motifs 15 isoform 1 preproprotein","950","This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active versicanase enzyme. This gene is located adjacent to a related ADAMTS gene (Adamts8) on chromosome 9. [provided by RefSeq, Jul 2016]. "
15704d15652
< "Q3U0K8-1","NP_808435.3","prolyl 3-hydroxylase OGFOD1 isoform 1","545",""
15709a15658
> "P58545-1","NP_001020602.1","BTB/POZ domain-containing protein 3 isoform 2","461",""
15711a15661
> "O35177-1","NP_001104794.1","enhancer of filamentation 1 isoform 1","833",""
15719c15669
< "Q3UNA4-1","NP_766370.2","NTF2-related export protein 2 isoform a","142",""
---
> "Q8CI59-1","NP_001078878.1","metalloreductase STEAP3","488",""
15721d15670
< "P70353-1","NP_032718.2","nuclear transcription factor Y subunit gamma isoform 1","335",""
15723,15724c15672
< "Q8K0B2-1","NP_080995.2","probable lysosomal cobalamin transporter isoform 1","537",""
< "Q9JJ04-1","NP_062778.2","beta-1,4-galactosyltransferase 4 precursor","344",""
---
> "Q3UHJ8-1","NP_001139497.1","RING finger protein 44 isoform 1","432",""
15725a15674,15676
> "Q60700-1","NP_001157115.1","mitogen-activated protein kinase kinase kinase 12","888",""
> "Q7TNH6-1","NP_082997.3","nephrocystin-3 isoform a","1325",""
> "Q3UEB3-1","NP_001158072.1","poly(U)-binding-splicing factor PUF60 isoform c","499",""
15727a15679
> "Q3U0P1-1","NP_001074707.1","partner and localizer of BRCA2 isoform 1","1104",""
15730d15681
< "Q99MD8-1","NP_085034.2","myoneurin isoform 1","610",""
15733,15734d15683
< "Q8BGS3-1","NP_598667.2","zinc finger protein with KRAB and SCAN domains 1 isoform 1","561",""
< "P97429-1","NP_038499.2","annexin A4","319",""
15735a15685
> "O89106-1","NP_001295215.1","bis(5'-adenosyl)-triphosphatase isoform 2","150","This gene encodes a member of the HIT family of proteins that are characterized by the presence of a histidine triad sequence. The encoded protein is a diadenosine triphosphate hydrolase enzyme that cleaves the P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. This locus is very fragile and has been found to be altered in different types of cancers. Mice lacking the encoded protein display increased susceptibility to spontaneous and induced tumors. Ectopic expression of the encoded protein in such knockout mice inhibits tumor development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. "
15738d15687
< "Q9DC63-1","NP_997598.1","F-box only protein 3 isoform 1","480",""
15749d15697
< "Q6P7W0-1","NP_666115.2","sentrin-specific protease 6 isoform 2","1132",""
15756c15704,15706
< "Q9DBQ7-1","NP_083052.1","protein-associating with the carboxyl-terminal domain of ezrin isoform 1","735",""
---
> "Q6P3A8-1","NP_001292864.1","2-oxoisovalerate dehydrogenase subunit beta, mitochondrial isoform 1","390","This gene encodes the beta chain of the branched chain alpha ketoacid dehydrogenase (Bckdh) complex. The encoded protein exists in a heterotetrameric complex containing the Bckdh alpha subunit to form the E1 catalytic component of Bckdh complex. The Bckdh complex catalyzes the oxidative decarboxylation of branched chain ketoacids to their corresponding acyl-CoA esters, during the catabolism of leucine, isoleucine and valine. In humans, certain mutations in this gene cause maple syrup urine disease. Alternative splicing results in multiple transcript variants encoding different isoforms. A pseudogene for this gene has been identified. [provided by RefSeq, Apr 2015]. "
> "Q9D842-1","NP_001163960.1","aprataxin and PNK-like factor isoform 1","499",""
> "Q499E5-1","NP_001107783.1","storkhead-box protein 2 isoform 1","926",""
15762a15713
> "Q8VDC1-1","NP_001103723.2","FYVE and coiled-coil domain-containing protein 1","1437",""
15765,15767d15715
< "P68134-1","NP_033736.1","actin, alpha skeletal muscle","377",""
< "Q96DY5-1","NP_033574.2","RING finger protein 112 isoform 1","654",""
< "P59384-1","NP_001316349.1","A disintegrin and metalloproteinase with thrombospondin motifs 15 isoform 2","619","This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active versicanase enzyme. This gene is located adjacent to a related ADAMTS gene (Adamts8) on chromosome 9. [provided by RefSeq, Jul 2016]. "
15771,15772c15719,15720
< "P23188-1","NP_035176.1","furin preproprotein","793","This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation during which an N-terminal propeptide is cleaved to generate the mature protein. Mice lacking the encoded protein die at an embryonic stage and display hemodynamic insufficiency, cardiac ventral closure defect, axial rotation defect and abnormal yolk sac vasculature. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]. "
< "Q3U0P1-1","NP_001276774.1","partner and localizer of BRCA2 isoform 5","384",""
---
> "Q80XQ8-1","NP_001153707.1","myelin-associated neurite-outgrowth inhibitor isoform 1","206",""
> "Q9JHR9-1","NP_001156330.1","nuclear receptor-interacting protein 2 isoform 1","270",""
15774a15723,15724
> "P97429-1","NP_001318049.1","annexin A4","319",""
> "P54615-1","NP_001292377.1","osteocalcin-related protein precursor","95",""
15776d15725
< "Q80YR4-1","NP_898972.1","E3 ubiquitin-protein ligase ZNF598 isoform 1","908",""
15777a15727
> "Q8BR27-1","NP_001240282.1","protein FAM214B","538",""
15780,15784c15730
< "Q14B70-1","NP_001277388.1","highly divergent homeobox isoform 2","634",""
< "O08543-1","NP_997537.1","ephrin-A5 isoform 1 precursor","228",""
< "Q9JM13-1","NP_064367.1","rab5 GDP/GTP exchange factor isoform a","491",""
< "P59900-1","NP_878260.1","EMILIN-3 isoform a precursor","758",""
< "Q5SUE8-1","NP_666136.1","ankyrin repeat domain-containing protein 40 isoform 2","324",""
---
> "Q3UNA4-1","NP_001154902.1","NTF2-related export protein 2 isoform a","142",""
15785a15732
> "Q14B71-1","NP_001103632.1","cell division cycle-associated protein 2","982",""
15787a15735
> "Q9JJ04-1","NP_001272722.1","beta-1,4-galactosyltransferase 4 precursor","344",""
15789,15791c15737,15739
< "Q99PM3-1","NP_780544.1","transcription initiation factor IIA subunit 1 isoform 2","339",""
< "Q80XC2-1","NP_796348.2","tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A","290",""
< "Q9R1E6-1","NP_056559.2","ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein","862","This gene encodes a member of the phosphodiesterase and nucleotide pyrophosphatase family of bifunctional enzymes that hydrolize phosphodiester bonds of various nucleotides. The encoded protein undergoes proteolytic processing to generate a mature protein with lysophospholipase D activity, catalyzing the cleavage of the choline group from lysophosphatidylcholine to produce lysophosphatidic acid. This gene is expressed in numerous tissues and participates in neural development, obesity, inflammation and oncogenesis. A complete lack of the encoded protein in mice results in aberrant vascular and neuronal development leading to embryonic lethality. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2015]. "
---
> "P04247-1","NP_001157519.1","myoglobin","154",""
> "Q9DBN4-1","NP_001239574.1","putative monooxygenase p33MONOX isoform 2","284",""
> "Q8BR07-1","NP_001106267.1","protein bicaudal D homolog 1 isoform 1","826",""
15792a15741
> "B2RPY5-1","NP_001074595.1","G-protein coupled receptor 161 isoform 1","558",""
15794a15744
> "P26150-1","NP_001155214.1","3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 isoform 1","373",""
15796,15797d15745
< "Q3UHJ8-1","NP_598825.2","RING finger protein 44 isoform 4","350",""
< "P10077-1","NP_035884.2","zinc finger protein 27","819",""
15798a15747
> "P00687-1","NP_001103975.1","alpha-amylase 1 precursor","511",""
15803c15752
< "P58545-1","NP_663509.2","BTB/POZ domain-containing protein 3 isoform 1","530",""
---
> "Q9DBR4-1","NP_001188343.1","amyloid-beta A4 precursor protein-binding family B member 2 isoform 3","738",""
15806,15807d15754
< "Q8K2L8-1","NP_848926.3","trafficking protein particle complex subunit 12 isoform 1","797",""
< "Q8VDC1-1","NP_683727.3","FYVE and coiled-coil domain-containing protein 1","1437",""
15810d15756
< "Q7JJ13-1","NP_034368.2","bromodomain-containing protein 2","798",""
15812,15813d15757
< "Q5XF89-1","NP_001121568.1","probable cation-transporting ATPase 13A3 isoform 1","1249",""
< "O70291-1","NP_062370.2","G protein-coupled receptor kinase 4 isoform 1","574",""
15814a15759,15760
> "Q3U2P1-1","NP_001277714.1","protein transport protein Sec24A isoform 2","1089",""
> "Q3U0K8-1","NP_001087226.1","prolyl 3-hydroxylase OGFOD1 isoform 2","502",""
15817c15763,15764
< "Q9JMD0-1","NP_035881.1","BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform 4","460",""
---
> "Q66JX5-1","NP_001183975.1","FGFR1 oncogene partner isoform 1","399",""
> "Q91ZT5-1","NP_001288747.1","FYVE, RhoGEF and PH domain-containing protein 4 isoform alpha","766","This gene is a member of the FYVE, RhoGEF and PH domain containing (FGD) family. The encoded protein is a Cdc42-specific guanine nucleotide exchange factor (GEF) that plays an essential role in regulating the actin cytoskeleton and cell morphology. Disruption of the gene in mouse causes abnormal nerve development and dysmyelination. Mutations in a similar gene in human can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. "
15818a15766
> "Q9D6M3-1","NP_001171047.1","mitochondrial glutamate carrier 1 isoform a","323",""
15822a15771
> "Q80T91-1","NP_001127871.1","multiple epidermal growth factor-like domains protein 11 isoform 1 precursor","1095",""
15823a15773
> "Q9JMD0-1","NP_001123641.1","BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform 1","495",""
15825,15826d15774
< "O89106-1","NP_034340.1","bis(5'-adenosyl)-triphosphatase isoform 2","150","This gene encodes a member of the HIT family of proteins that are characterized by the presence of a histidine triad sequence. The encoded protein is a diadenosine triphosphate hydrolase enzyme that cleaves the P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. This locus is very fragile and has been found to be altered in different types of cancers. Mice lacking the encoded protein display increased susceptibility to spontaneous and induced tumors. Ectopic expression of the encoded protein in such knockout mice inhibits tumor development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. "
< "P26150-1","NP_001155217.1","3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 isoform 1","373",""
15828a15777
> "Q9Z248-1","NP_001005605.1","zinc finger protein AEBP2 isoform 1","496",""
15833d15781
< "Q18PI6-1","NP_038517.1","SLAM family member 5 isoform 1 precursor","329",""
15836d15783
< "Q3UMB5-1","NP_780700.1","guanine nucleotide exchange protein SMCR8 isoform 2","785",""
15838,15839c15785,15786
< "Q9CYR0-1","NP_997633.1","single-stranded DNA-binding protein, mitochondrial isoform 1","148",""
< "Q8BR07-1","NP_033883.2","protein bicaudal D homolog 1 isoform 2","835",""
---
> "Q9Z139-1","NP_001299619.1","inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 2 precursor","161","This gene encodes a receptor tyrosine kinase that has been implicated in nervous system development, specifically in the maintenance of neural progenitor cell fate, neurite extension and synapse formation. The encoded protein, likely a pseudokinase that lacks catalytic activity, may also regulate adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. "
> "O08543-1","NP_034239.1","ephrin-A5 isoform 2 precursor","201",""
15844c15791
< "P54615-1","NP_112736.3","osteocalcin-related protein precursor","95",""
---
> "Q8C4X1-1","NP_001334540.1","centromere protein X isoform 2","107",""
15848,15851c15795
< "Q8K214-1","NP_038911.1","polycomb protein SCMH1 isoform 1","664",""
< "O35177-1","NP_059492.3","enhancer of filamentation 1 isoform 2","833",""
< "Q8R3Q6-1","NP_941047.1","coiled-coil domain-containing protein 58 isoform 1","144",""
< "Q6P3A8-1","NP_954665.1","2-oxoisovalerate dehydrogenase subunit beta, mitochondrial isoform 2","322","This gene encodes the beta chain of the branched chain alpha ketoacid dehydrogenase (Bckdh) complex. The encoded protein exists in a heterotetrameric complex containing the Bckdh alpha subunit to form the E1 catalytic component of Bckdh complex. The Bckdh complex catalyzes the oxidative decarboxylation of branched chain ketoacids to their corresponding acyl-CoA esters, during the catabolism of leucine, isoleucine and valine. In humans, certain mutations in this gene cause maple syrup urine disease. Alternative splicing results in multiple transcript variants encoding different isoforms. A pseudogene for this gene has been identified. [provided by RefSeq, Apr 2015]. "
---
> "O70291-1","NP_001074212.1","G protein-coupled receptor kinase 4 isoform 2","177",""
15852a15797
> "Q8K2L8-1","NP_001154882.1","trafficking protein particle complex subunit 12 isoform 1","797",""
15854d15798
< "Q8BRG8-1","NP_848740.3","transmembrane protein 209 isoform 1","561",""
15858,15859c15802
< "Q60700-1","NP_033608.3","mitogen-activated protein kinase kinase kinase 12","888",""
< "Q9DBN4-1","NP_598558.1","putative monooxygenase p33MONOX isoform 1","303",""
---
> "P10077-1","NP_001032796.1","zinc finger protein 27","819",""
15861a15805
> "Q5SVR0-1","NP_001277688.1","TBC1 domain family member 9B isoform 2","1262",""
15864d15807
< "Q33DR3-1","NP_082048.2","decaprenyl-diphosphate synthase subunit 2 isoform 1","401",""
15866a15810,15811
> "Q3UTH8-1","NP_001028501.1","rho guanine nucleotide exchange factor 9 isoform a","516",""
> "Q5XF89-1","NP_001121566.1","probable cation-transporting ATPase 13A3 isoform 2","1219",""
15867a15813
> "Q8CHP5-1","NP_001164340.1","partner of Y14 and mago isoform 2","202",""
15868a15815
> "Q8R3Q6-1","NP_001152893.1","coiled-coil domain-containing protein 58 isoform 2","102",""
15872a15820,15821
> "P68134-1","NP_001258970.1","actin, alpha skeletal muscle","377",""
> "Q99MD8-1","NP_001276550.1","myoneurin isoform 2","582",""
15874a15824,15825
> "Q62447-1","NP_001277351.1","cyclin-C isoform 2","282",""
> "Q3UMB5-1","NP_001078909.1","guanine nucleotide exchange protein SMCR8 isoform 1","935",""
15875a15827
> "P60954-1","NP_001154955.1","nucleolar protein 4 isoform 1","564",""
15877a15830
> "Q05020-1","NP_001264873.1","apolipoprotein C-II precursor","97",""
15878a15832
> "Q9R112-1","NP_001155975.1","sulfide:quinone oxidoreductase, mitochondrial","450",""
15883d15836
< "Q9D113-1","NP_081104.1","DNL-type zinc finger protein isoform 1","177",""
15886d15838
< "Q2KN98-1","NP_700455.3","cytospin-A isoform b","1118",""
15892,15893c15844
< "Q80TJ1-1","NP_036191.2","calcium-dependent secretion activator 1 isoform 1","1361",""
< "Q4QQM5-1","NP_777357.2","mitoguardin 1 isoform 1","600",""
---
> "Q9WUD8-1","NP_001116323.1","fas apoptotic inhibitory molecule 1 isoform Faim-L","201",""
15895a15847
> "Q9JJB9-1","NP_001035950.1","transmembrane protein 183 isoform b","374",""
15911,15912c15863
< "Q8VCR2-1","NP_932147.2","17-beta-hydroxysteroid dehydrogenase 13 isoform 2 precursor","304",""
< "Q8BG26-1","NP_082464.2","RUN and SH3 domain-containing protein 1 isoform 1","1030",""
---
> "Q91YU6-1","NP_001123997.1","leucine zipper putative tumor suppressor 2","671",""
15917c15868
< "Q9QYE6-1","NP_038775.1","golgin subfamily A member 5","729",""
---
> "Q9D321-1","NP_001076786.1","probable UDP-sugar transporter protein SLC35A4","324",""
15919c15870
< "Q9JJ80-1","NP_075812.3","ribosome production factor 2 homolog isoform 1","306",""
---
> "Q9D2G5-1","NP_001106822.1","synaptojanin-2 isoform d","1171",""
15922c15873,15874
< "Q6NV83-1","NP_080752.2","U2 snRNP-associated SURP motif-containing protein isoform 2","985",""
---
> "Q99KB8-1","NP_001153098.1","hydroxyacylglutathione hydrolase, mitochondrial isoform 2","260",""
> "Q8BGB7-1","NP_001156507.1","enolase-phosphatase E1","257",""
15923a15876
> "Q62276-1","NP_001029080.1","mediator of RNA polymerase II transcription subunit 22 isoform 2","200",""
15927,15929c15880
< "P08042-1","NP_035872.2","zinc finger protein 1 isoform 2","389",""
< "Q9D321-1","NP_080680.2","probable UDP-sugar transporter protein SLC35A4","324",""
< "Q62276-1","NP_035643.1","mediator of RNA polymerase II transcription subunit 22 isoform 1","140",""
---
> "Q9JIY8-1","NP_001032931.1","N-acetyltransferase family 8 member 3","227",""
15931c15882
< "Q8R5G7-1","NP_631945.2","arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 1","1538","This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
---
> "Q9CXY9-1","NP_079938.1","GPI-anchor transamidase isoform 1 precursor","395",""
15933a15885
> "Q9CX83-1","NP_001159849.1","armadillo repeat-containing X-linked protein 1","456",""
15940,15941c15892,15893
< "Q8BGB7-1","NP_080697.2","enolase-phosphatase E1","257",""
< "Q3UL97-1","NP_694763.2","activating transcription factor 7-interacting protein 2 isoform 1","452",""
---
> "Q9DAA6-1","NP_001158033.1","exosome complex component CSL4 isoform 2","154",""
> "Q9Z2W8-1","NP_001106651.1","glutamate receptor 4 isoform 2 precursor","902","Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]. "
15946d15897
< "Q8CBF3-1","NP_775623.3","ephrin type-B receptor 1 isoform 1 precursor","984",""
15950d15900
< "Q8VEE4-1","NP_080929.1","replication protein A 70 kDa DNA-binding subunit isoform 2","623",""
15958d15907
< "Q8BFR5-1","NP_766333.1","elongation factor Tu, mitochondrial isoform 1","452",""
15960d15908
< "Q8R0A2-1","NP_766353.2","zinc finger and BTB domain-containing protein 44 isoform b","435",""
15967d15914
< "P60840-1","NP_062507.1","alpha-endosulfine isoform a","121",""
15972,15973d15918
< "Q2TB54-1","NP_659209.2","high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform 2 precursor","535",""
< "Q9CR78-1","NP_082413.2","myb/SANT-like DNA-binding domain-containing protein 3","275",""
15980d15924
< "Q9DAA6-1","NP_079920.1","exosome complex component CSL4 isoform 1","195",""
15982a15927
> "Q68SN8-1","NP_001106709.1","Fc receptor-like protein 5 isoform b precursor","508",""
15992d15936
< "A3KGF7-1","NP_808236.2","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform a","1181",""
15999c15943
< "Q9Z2W8-1","NP_062665.3","glutamate receptor 4 isoform 1 precursor","902","Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]. "
---
> "Q80TL7-1","NP_001156496.1","protein MON2 homolog isoform 1","1715",""
16002d15945
< "A2AWP8-1","NP_766003.3","rho guanine nucleotide exchange factor 10-like protein isoform a","1275",""
16007d15949
< "Q8BHJ9-1","NP_945174.1","pre-mRNA-splicing factor SLU7","585","Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]. "
16014c15956
< "Q9QXU7-1","NP_056583.1","prokineticin-2 isoform 1 precursor","128",""
---
> "Q8CBF3-1","NP_001161768.1","ephrin type-B receptor 1 isoform 2 precursor","943",""
16017a15960
> "Q8R0A2-1","NP_001108602.1","zinc finger and BTB domain-containing protein 44 isoform a","453",""
16023a15967
> "Q8CAF4-1","NP_001157064.1","NHS-like protein 1 isoform 2","1583",""
16028d15971
< "Q91ZZ5-1","NP_536716.2","relaxin receptor 2 isoform 1 precursor","737",""
16031d15973
< "Q8VCU1-1","NP_653094.2","carboxylesterase 3B isoform 1 precursor","571",""
16034d15975
< "Q8BQZ8-1","NP_775593.1","potassium voltage-gated channel subfamily S member 3","491",""
16039a15981,15982
> "Q71FD7-1","NP_001156728.1","filamin-binding LIM protein 1","375",""
> "Q8C8V1-1","NP_084536.2","zinc finger protein ZXDC isoform 1","712",""
16050d15992
< "Q3UZ39-1","NP_032541.1","leucine-rich repeat flightless-interacting protein 1 isoform 2","628",""
16054a15997
> "Q9CR78-1","NP_001139396.1","myb/SANT-like DNA-binding domain-containing protein 3","275",""
16060a16004
> "Q8BFR5-1","NP_001157185.1","elongation factor Tu, mitochondrial isoform 2","435",""
16063c16007
< "Q80ZA7-1","NP_778158.2","fragile X mental retardation 1 neighbor protein isoform 1","238",""
---
> "Q3U288-1","NP_001139471.1","zinc finger protein 710 isoform a","666",""
16076d16019
< "Q9CQK8-1","NP_035598.2","small proline-rich protein 2A","83",""
16081c16024,16025
< "Q9ERH4-1","NP_598612.1","nucleolar and spindle-associated protein 1 isoform a","427",""
---
> "Q8BPQ7-1","NP_001156437.1","small G protein signaling modulator 1 isoform b","1069",""
> "Q8C9A2-3","NP_001158108.1","endonuclease V isoform 1","338",""
16085d16028
< "Q9Z2W0-1","NP_058574.3","aspartyl aminopeptidase isoform b","473",""
16087c16030
< "Q69ZU8-1","NP_536719.2","ankyrin repeat domain-containing protein 6","712","This gene encodes a protein which is thought to be involved in the Wnt signaling pathway and embryonic axis formation. Similar genes have been found in human, rhesus macaque, and zebrafish. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. "
---
> "Q80ZA7-1","NP_001160091.1","fragile X mental retardation 1 neighbor protein isoform 2","192",""
16089c16032
< "Q8VDF2-1","NP_035061.3","E3 ubiquitin-protein ligase UHRF1 isoform A","782",""
---
> "Q9Z2W0-1","NP_001104301.1","aspartyl aminopeptidase isoform a","475",""
16093d16035
< "Q61456-1","NP_031654.2","cyclin-A1","421",""
16096d16037
< "E9PYI1-1","NP_001161345.1","zinc finger protein 568 isoform 2","670",""
16097a16039
> "Q9ERH4-1","NP_001036117.1","nucleolar and spindle-associated protein 1 isoform b","394",""
16100d16041
< "P50295-1","NP_035004.1","arylamine N-acetyltransferase 2","290",""
16110c16051
< "Q920B0-1","NP_660130.2","FERM domain-containing protein 4B isoform 3","981",""
---
> "Q8CIV3-1","NP_001077363.1","lipase member H isoform 1 precursor","451",""
16113d16053
< "Q8K136-1","NP_081289.2","sodium channel modifier 1 isoform 1","186","Mutations in the voltage-gated sodium channel gene Scn8a lead to neurological problems in mice. For one particular mutation, Scn8amedJ, mice live to adulthood but have tremors and muscle weakness, among other problems, in all strains except those derived from C57BL6 mice. In these strains, the product of the Scnm1 gene (229 aa) partially overcomes the effects of the Scn8amedJ mutation. However, in C57BL6-derived mice, a one nt change in the penultimate exon creates a premature stop codon, truncating the Scnm1 protein at 186 aa. This truncated protein lacks the ability to overcome the effects of the Scn8amedJ mutation, and these mice suffer paralysis and juvenile death. [provided by RefSeq, Jul 2009]. "
16127d16066
< "Q91WP0-1","NP_034897.1","mannan-binding lectin serine protease 2 isoform 2 precursor","185",""
16129a16069
> "Q6NV83-1","NP_001108449.1","U2 snRNP-associated SURP motif-containing protein isoform 1","1029",""
16131d16070
< "Q9D2V5-1","NP_080937.3","protein AAR2 homolog","384",""
16137a16077
> "P61600-1","NP_001135437.1","N-alpha-acetyltransferase 20 isoform 1","178",""
16147a16088
> "Q9QXU7-1","NP_001032628.1","prokineticin-2 isoform 2 precursor","107",""
16155,16156d16095
< "Q8R1D1-1","NP_666333.1","zinc finger protein 426 isoform 1","550",""
< "O88632-1","NP_035479.2","semaphorin-3F isoform 2 precursor","754",""
16157a16097
> "Q8BWY7-1","NP_001159975.1","zinc transporter ZIP11 isoform 1","342",""
16162d16101
< "Q71FD7-1","NP_598515.3","filamin-binding LIM protein 1","375",""
16165d16103
< "O08912-1","NP_038842.3","polypeptide N-acetylgalactosaminyltransferase 1","559",""
16168,16170d16105
< "Q9CX83-1","NP_084342.1","armadillo repeat-containing X-linked protein 1","456",""
< "Q9JJB9-1","NP_065613.1","transmembrane protein 183 isoform a","375",""
< "Q8C8V1-1","NP_766590.1","zinc finger protein ZXDC isoform 2","858",""
16177a16113,16114
> "P0DPE0-1","NP_079738.2","EEF1A lysine methyltransferase 4","255","This gene encodes a member of the lysine-specific methyltransferase (KMT) family. The encoded enzyme catalyzes the methylation of lysine-36 of the eukaryotic translation elongation factor 1 alpha. Methylation by this enzyme may affect endoplasmic reticulum-related processes. [provided by RefSeq, Jul 2017]. "
> "Q8R2R5-1","NP_001103630.1","leucine-rich repeat-containing protein 61","259",""
16186d16122
< "Q91YU6-1","NP_663478.2","leucine zipper putative tumor suppressor 2","671",""
16189d16124
< "Q80VJ2-1","NP_079567.2","steroid receptor RNA activator 1 isoform a","232",""
16191d16125
< "Q920R0-1","NP_666221.1","alsin isoform 2","928",""
16193d16126
< "Q80VC9-1","NP_081447.2","calmodulin-regulated spectrin-associated protein 3 isoform 2","1252",""
16198a16132
> "Q80TJ1-1","NP_001036082.1","calcium-dependent secretion activator 1 isoform 2","1355",""
16203a16138
> "Q61767-1","NP_001104806.1","NADPH-dependent 3-keto-steroid reductase Hsd3b4","373",""
16215a16151,16152
> "Q8VDF2-1","NP_001104548.1","E3 ubiquitin-protein ligase UHRF1 isoform A","782",""
> "Q80VJ2-1","NP_001157878.1","steroid receptor RNA activator 1 isoform b","151",""
16217d16153
< "Q8VBW1-1","NP_598748.1","sodium- and chloride-dependent creatine transporter 1 isoform 1","640",""
16219d16154
< "Q8BVK9-1","NP_780606.3","sp110 nuclear body protein","445",""
16221d16155
< "Q68SN8-1","NP_899045.3","Fc receptor-like protein 5 isoform a precursor","596",""
16222a16157
> "Q8BHJ9-1","NP_683514.2","pre-mRNA-splicing factor SLU7","585","Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]. "
16223a16159
> "Q8C0D5-1","NP_001153144.1","elongation factor-like GTPase 1","1127",""
16226a16163
> "Q3UL97-1","NP_083529.1","activating transcription factor 7-interacting protein 2 isoform 2","300",""
16233d16169
< "P61600-1","NP_080701.1","N-alpha-acetyltransferase 20 isoform 2","188",""
16238c16174
< "Q6PB60-1","NP_937804.1","protein BHLHb9","539",""
---
> "Q8VCU1-1","NP_001152887.1","carboxylesterase 3B isoform 2 precursor","521",""
16244a16181
> "O08912-1","NP_001153876.1","polypeptide N-acetylgalactosaminyltransferase 1","559",""
16247d16183
< "Q9CXY9-1","NP_821135.1","GPI-anchor transamidase isoform 2 precursor","442",""
16249d16184
< "Q8BPQ7-1","NP_766306.2","small G protein signaling modulator 1 isoform a","1093",""
16250a16186,16188
> "Q69ZU8-1","NP_001012453.1","ankyrin repeat domain-containing protein 6","712","This gene encodes a protein which is thought to be involved in the Wnt signaling pathway and embryonic axis formation. Similar genes have been found in human, rhesus macaque, and zebrafish. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. "
> "Q8BQZ8-1","NP_001162036.1","potassium voltage-gated channel subfamily S member 3","491",""
> "Q61858-1","NP_001122069.1","G patch domain and ankyrin repeat-containing protein 1 isoform 2","349",""
16251a16190
> "Q8VEE4-1","NP_001157695.1","replication protein A 70 kDa DNA-binding subunit isoform 1","644",""
16254d16192
< "B1AY10-1","NP_076228.2","transcriptional repressor NF-X1 isoform 1","1114",""
16256a16195
> "Q5I012-1","NP_001158270.1","putative sodium-coupled neutral amino acid transporter 10 isoform 2","1089",""
16261d16199
< "Q8R2R5-1","NP_808404.2","leucine-rich repeat-containing protein 61","259",""
16262a16201
> "Q2KN98-1","NP_001139298.1","cytospin-A isoform a","1135",""
16268c16207
< "Q925Q3-1","NP_573484.2","mitochondrial sodium/calcium exchanger protein isoform 1 precursor","585",""
---
> "Q9Z2X1-1","NP_001159899.1","heterogeneous nuclear ribonucleoprotein F","415",""
16272a16212
> "Q8VBW1-1","NP_001136281.1","sodium- and chloride-dependent creatine transporter 1 isoform 2","635",""
16276a16217
> "Q9JJ80-1","NP_001036021.1","ribosome production factor 2 homolog isoform 2","273",""
16278a16220
> "Q69ZB8-1","NP_001116147.1","zinc finger CCHC domain-containing protein 2 isoform B","1155",""
16286,16287c16228
< "Q9CQF6-1","NP_080552.3","L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase isoform 1","309",""
< "Q8CDU6-1","NP_766225.2","probable E3 ubiquitin-protein ligase HECTD2 isoform 2","774",""
---
> "Q920R0-1","NP_001153420.2","alsin isoform 1","1651",""
16294d16234
< "O70258-1","NP_035490.3","epsilon-sarcoglycan isoform 4","437",""
16300a16241
> "Q8C2S5-1","NP_001153435.1","F-box/LRR-repeat protein 5 isoform A","690",""
16305a16247
> "Q9D113-1","NP_001132975.1","DNL-type zinc finger protein isoform 2","82",""
16312a16255
> "A2AWP8-1","NP_001106193.1","rho guanine nucleotide exchange factor 10-like protein isoform b","1241",""
16314a16258
> "Q3SYK4-1","NP_001028948.1","vertnin","740",""
16316d16259
< "Q9Z2C4-1","NP_058681.1","myotubularin-related protein 1 isoform A","669",""
16319a16263,16264
> "Q8R1D1-1","NP_001103779.1","zinc finger protein 426 isoform 1","550",""
> "P60840-1","NP_001021383.1","alpha-endosulfine isoform b","117",""
16321,16322d16265
< "Q8JZR6-1","NP_067505.2","electroneutral sodium bicarbonate exchanger 1 isoform 1","1089",""
< "C0HKG6-1","NP_080887.1","ribonuclease T2-B precursor","259",""
16326d16268
< "Q80XI1-1","NP_084512.2","F-box only protein 34 isoform 1","746",""
16328a16271,16272
> "P50295-1","NP_001162049.1","arylamine N-acetyltransferase 2","290",""
> "Q6I6G8-1","NP_001001883.1","E3 ubiquitin-protein ligase HECW2 isoform 1","1578",""
16334d16277
< "Q61858-1","NP_115849.2","G patch domain and ankyrin repeat-containing protein 1 isoform 1 precursor","372",""
16339a16283
> "Q8K136-1","NP_001157045.1","sodium channel modifier 1 isoform 2","164","Mutations in the voltage-gated sodium channel gene Scn8a lead to neurological problems in mice. For one particular mutation, Scn8amedJ, mice live to adulthood but have tremors and muscle weakness, among other problems, in all strains except those derived from C57BL6 mice. In these strains, the product of the Scnm1 gene (229 aa) partially overcomes the effects of the Scn8amedJ mutation. However, in C57BL6-derived mice, a one nt change in the penultimate exon creates a premature stop codon, truncating the Scnm1 protein at 186 aa. This truncated protein lacks the ability to overcome the effects of the Scn8amedJ mutation, and these mice suffer paralysis and juvenile death. [provided by RefSeq, Jul 2009]. "
16345d16288
< "Q61702-1","NP_032432.2","inter-alpha-trypsin inhibitor heavy chain H1 isoform 1 preproprotein","907","This gene encodes a heavy chain of inter-alpha trypsin inhibitor (IaI) family of plasma serine protease inhibitors. IaI proteins are protein-glycosaminoglycan-protein complexes comprised of two heavy chains and a light chain. The encoded protein covalently associates with the light chain via a chondroitin sulfate moiety. Intravenous administration of the encoded protein improved survival of mice after infection with Escherichia coli. This gene is located adjacent to two other IaI heavy chain genes. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature protein. [provided by RefSeq, Oct 2015]. "
16350d16292
< "Q8C9A2-3","NP_796368.1","endonuclease V isoform 2","255",""
16356,16360d16297
< "Q6I6G8-1","NP_766243.2","E3 ubiquitin-protein ligase HECW2 isoform 2","294",""
< "Q8C0D5-1","NP_780526.2","elongation factor-like GTPase 1","1127",""
< "Q9D2G5-1","NP_035653.2","synaptojanin-2 isoform c","1216",""
< "Q9ER88-1","NP_075370.2","28S ribosomal protein S29, mitochondrial isoform 2","396",""
< "Q61584-1","NP_032079.1","fragile X mental retardation syndrome-related protein 1 isoform 3","539",""
16369a16307
> "Q91WP0-1","NP_001003893.1","mannan-binding lectin serine protease 2 isoform 1 precursor","685",""
16374a16313,16314
> "Q9ER88-1","NP_001158005.1","28S ribosomal protein S29, mitochondrial isoform 1","366",""
> "Q6RFH4-1","NP_001152769.1","germinal center-associated signaling and motility protein isoform 1","181",""
16375a16316
> "Q3UPH7-1","NP_001139393.1","rho guanine nucleotide exchange factor 40 isoform 2","1476",""
16380c16321,16322
< "P81069-1","NP_766100.1","GA-binding protein subunit beta-2","414",""
---
> "O70258-1","NP_001123660.1","epsilon-sarcoglycan isoform 1","473",""
> "Q4QQM5-1","NP_001155847.1","mitoguardin 1 isoform 2","536",""
16384,16385d16325
< "Q80TL7-1","NP_700444.2","protein MON2 homolog isoform 3","1708",""
< "Q91VM5-1","NP_033059.2","RNA binding motif protein, X-linked-like-1","388",""
16388d16327
< "Q3UPH7-1","NP_937892.2","rho guanine nucleotide exchange factor 40 isoform 1","1517",""
16390d16328
< "Q9JLK7-1","NP_038907.1","calcium-binding protein 1 isoform 2","227",""
16397a16336
> "Q80XI1-1","NP_001139557.1","F-box only protein 34 isoform 2","695",""
16404d16342
< "Q8VBW5-1","NP_081720.2","HMG box transcription factor BBX isoform 1","907",""
16415d16352
< "Q6RFH4-1","NP_032125.3","germinal center-associated signaling and motility protein isoform 2","159",""
16421a16359
> "Q8BG26-1","NP_001077276.1","RUN and SH3 domain-containing protein 1 isoform 2","893",""
16422a16361,16362
> "Q8CDU6-1","NP_001156943.1","probable E3 ubiquitin-protein ligase HECTD2 isoform 1","775",""
> "P81069-1","NP_084161.1","GA-binding protein subunit beta-2","414",""
16424a16365
> "Q8BJL1-1","NP_001161769.1","F-box only protein 30","746",""
16429d16369
< "Q9WTJ4-1","NP_035943.3","flt3-interacting zinc finger protein 1","500",""
16437d16376
< "Q8CAF4-1","NP_775566.3","NHS-like protein 1 isoform 1","1587",""
16439a16379
> "Q2TB54-1","NP_001164103.1","high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform 1","591",""
16448,16449d16387
< "Q9R112-1","NP_067482.4","sulfide:quinone oxidoreductase, mitochondrial","450",""
< "E9Q9A9-1","NP_660262.2","2'-5'-oligoadenylate synthase 2 isoform 2","742",""
16458d16395
< "Q05860-1","NP_034360.2","formin-1 isoform 1","1466",""
16463,16465d16399
< "A2A6C4-1","NP_950184.2","signal peptide peptidase-like 2C isoform a precursor","690",""
< "Q9WUD8-1","NP_035940.3","fas apoptotic inhibitory molecule 1 isoform Faim-S","179",""
< "Q8BWY7-1","NP_081492.4","zinc transporter ZIP11 isoform 2","335",""
16469a16404
> "P08042-1","NP_001032754.1","zinc finger protein 1 isoform 1","403",""
16472c16407
< "Q69ZB8-1","NP_001116148.1","zinc finger CCHC domain-containing protein 2 isoform A","1166",""
---
> "E9PYI1-1","NP_001028527.2","zinc finger protein 568 isoform 1","671",""
16473a16409
> "Q9D2V5-1","NP_001158290.1","protein AAR2 homolog","384",""
16475c16411
< "Q9JJG7-1","NP_851388.1","calcium-binding protein 8 isoform a","261",""
---
> "Q3UZ39-1","NP_001104781.1","leucine-rich repeat flightless-interacting protein 1 isoform 1","729",""
16478d16413
< "Q8C181-1","NP_997398.1","muscleblind-like protein 2 isoform 2","355",""
16483d16417
< "Q8BJL1-1","NP_082244.2","F-box only protein 30","746",""
16487d16420
< "Q61767-1","NP_032320.1","NADPH-dependent 3-keto-steroid reductase Hsd3b4","373",""
16491c16424,16427
< "Q9D9S1-1","NP_613047.1","UPF0193 protein EVG1 homolog isoform 1","216",""
---
> "Q61584-1","NP_001106659.1","fragile X mental retardation syndrome-related protein 1 isoform 1","677",""
> "Q8VCR2-1","NP_001156958.1","17-beta-hydroxysteroid dehydrogenase 13 isoform 1 precursor","300",""
> "A2A6C4-1","NP_001076004.1","signal peptide peptidase-like 2C isoform b precursor","581",""
> "Q9JJG7-1","NP_067346.1","calcium-binding protein 8 isoform b","219",""
16499d16434
< "Q9QXN0-1","NP_056571.2","protein Shroom3 isoform 1","1980",""
16503d16437
< "Q3U288-1","NP_780642.3","zinc finger protein 710 isoform a","666",""
16508c16442,16443
< "Q8C2S5-1","NP_848844.1","F-box/LRR-repeat protein 5 isoform B","623",""
---
> "Q8C181-1","NP_780550.1","muscleblind-like protein 2 isoform 1","373",""
> "Q09200-1","NP_032106.1","beta-1,4 N-acetylgalactosaminyltransferase 1 isoform 1","533",""
16509a16445,16446
> "Q9CXC3-1","NP_001276559.1","mitochondrial genome maintenance exonuclease 1","338",""
> "O70152-1","NP_001297013.1","dolichol-phosphate mannosyltransferase subunit 1 isoform 2","237",""
16511a16449
> "Q9D9S1-1","NP_001297505.1","UPF0193 protein EVG1 homolog isoform 2","195",""
16513d16450
< "Q9DAM5-1","NP_080347.1","mitochondrial thiamine pyrophosphate carrier isoform 1","318",""
16516d16452
< "Q9CQ58-1","NP_075821.1","prolactin-8A9 isoform 1 precursor","241",""
16519c16455
< "D3KU66-1","NP_001295417.1","acetylserotonin O-methyltransferase isoform 2","387","This gene belongs to the methyltransferase superfamily and is located in the pseudoautosomal region (PAR) of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin and is abundant in the pineal gland. Two amino acid substitutions (R78G and R242C) are present in the encoded protein derived from the reference strain, C57BL/6J, and this protein shows low enzyme activity relative to the protein derived from other strains. [provided by RefSeq, May 2015]. "
---
> "Q8C0P7-1","NP_001277628.1","E3 SUMO-protein ligase ZNF451 isoform 2","895",""
16520a16457,16458
> "O35149-1","NP_001277922.1","zinc transporter 4 isoform b","381",""
> "Q5DTU0-1","NP_001171267.1","actin filament-associated protein 1-like 2 isoform 1","843",""
16522,16525c16460
< "P56581-1","NP_766140.2","G/T mismatch-specific thymine DNA glycosylase isoform 2","421",""
< "Q80U23-1","NP_937857.1","syntaphilin isoform a","528",""
< "P46662-1","NP_035028.2","merlin isoform 2","596",""
< "P30115-1","NP_034486.2","glutathione S-transferase A3 isoform a","221",""
---
> "Q61979-1","NP_001278057.1","neuronatin isoform c","129",""
16529c16464
< "Q80UK7-1","NP_082625.2","spindle assembly abnormal protein 6 homolog isoform 1","654",""
---
> "Q9JIT1-1","NP_001276686.1","RING finger protein 32","368",""
16531c16466,16469
< "Q6NZF1-1","NP_653113.4","zinc finger CCCH domain-containing protein 11A","792",""
---
> "A2AR50-1","NP_001277499.1","ras-specific guanine nucleotide-releasing factor RalGPS1 isoform b","497",""
> "P30115-1","NP_001070821.1","glutathione S-transferase A3 isoform a","221",""
> "Q8C569-1","NP_001273533.1","protein FAM118B isoform 1","351",""
> "Q8BM92-1","NP_001303672.1","cadherin-7 isoform 1 preproprotein","785","This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene is located adjacent to a related cadherin gene on chromosome 1. [provided by RefSeq, Oct 2015]. "
16533,16534c16471,16472
< "Q9Z0H0-1","NP_033993.2","cell division cycle 7-related protein kinase isoform 1","564",""
< "O35613-1","NP_031855.3","death domain-associated protein 6","740",""
---
> "Q9DCP2-1","NP_001186146.1","sodium-coupled neutral amino acid transporter 3","505",""
> "Q8CC84-1","NP_001177980.1","lysM and putative peptidoglycan-binding domain-containing protein 4 isoform A","293",""
16536c16474
< "Q06985-1","NP_033199.1","E3 ubiquitin-protein ligase SIAH1B","282","This gene encodes a member of the seven in absentia homolog (Siah) family of E3 ubiquitin ligase enzymes that catalyze the transfer of ubiquitin to substrate proteins. The encoded protein targets Pard3A (partitioning defective 3A) protein for proteasome-mediated degradation during the exit of cerebellar granule neurons from their germinal zone niche. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]. "
---
> "Q9WTM3-1","NP_001258953.1","semaphorin-6C isoform 1 precursor","963",""
16539,16541c16477,16478
< "Q8R0X2-1","NP_084473.1","CDK2-associated and cullin domain-containing protein 1 isoform 1","377",""
< "Q8C5H8-1","NP_001273184.1","NAD kinase 2, mitochondrial isoform 4","402",""
< "Q9JJT2-1","NP_064398.1","GDNF family receptor alpha-4 isoform 2","302","This gene encodes a transmembrane protein that functions as the receptor for persephin, a member of the glial cell line derived neurotrophic factors. The encoded protein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-anchored cell surface coreceptor that forms a complex with the receptor tyrosine kinase Ret. A complete lack of the encoded protein impairs production of thyroid calcitonin and increases the rate of bone formation in young mice. [provided by RefSeq, Jul 2016]. "
---
> "Q8K023-1","NP_001333464.1","aldo-keto reductase family 1 member C18 isoform 2","297",""
> "P10598-1","NP_001272949.1","beta-casein isoform b precursor","230",""
16542a16480
> "P16294-1","NP_001292726.1","coagulation factor IX isoform 2","433","This gene encodes a vitamin K-dependent serine protease that plays a critical role in the intrinsic pathway of blood coagulation. The encoded protein is an inactive zymogen that is activated by coagulation factor XIa to generate factor IXa, a heterodimer containing heavy and light chains. In association with factor VIII, membrane phospholipids and calcium ions, factor IXa cleaves the inactive zymogen factor X to generate active factor Xa. Genetic deletion of this gene in mice results in a severe bleeding phenotype. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
16543a16482,16483
> "Q3UMC0-1","NP_001156983.1","ATPase family protein 2 homolog isoform 1","893",""
> "Q9JLK7-1","NP_001297644.1","calcium-binding protein 1 isoform 3","167",""
16545d16484
< "Q9Z275-1","NP_065624.1","retinaldehyde-binding protein 1","317",""
16548c16487
< "Q9JHE4-1","NP_058618.2","galactosylceramide sulfotransferase","423",""
---
> "Q8CEC0-1","NP_001076800.1","nuclear pore complex protein Nup88 isoform 2","753",""
16551a16491
> "Q8VCF1-1","NP_001020788.1","soluble calcium-activated nucleotidase 1 isoform a","403","The protein encoded by this gene is a calcium-dependent nucleotidase that preferentially hydrolyzes UDP, GDP, and IDP. The encoded protein has low activity with ADP and ATP and shows no activity with AMP and GMP. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]. "
16553a16494
> "P63056-1","NP_694797.1","noelin-3 isoform B precursor","478",""
16555,16557c16496,16497
< "Q6PA06-1","NP_835151.2","atlastin-2 isoform 2","412",""
< "Q9Z2Y2-1","NP_059073.1","beta-1,4-galactosyltransferase 2","369",""
< "Q3U1U7-1","NP_033774.1","aryl hydrocarbon receptor repressor isoform 1","701","This gene encodes a protein that represses aryl hydrocarbon receptor-dependent signaling. The encoded protein competes with the aryl hydrocarbon receptor transcription factor for heterodimerization with the aryl hydrocarbon receptor nuclear translocator protein and binding to xenobiotic response element (XRE) sequence in many genes. This protein is implicated in the regulation of cell growth and differentiation as well as mediating dioxin toxicity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]. "
---
> "Q80XB4-1","NP_001273481.1","nebulin-related-anchoring protein isoform 3","1612",""
> "Q05860-1","NP_001272388.1","formin-1 isoform 4","1204",""
16559c16499
< "Q3TTE0-1","NP_031427.2","disintegrin and metalloproteinase domain-containing protein 5 isoform 3 preproprotein","751","This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of related ADAM genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]. "
---
> "Q9CPR5-1","NP_001171129.1","39S ribosomal protein L15, mitochondrial isoform 1 precursor","295",""
16561d16500
< "P49718-1","NP_032592.2","DNA replication licensing factor MCM5","734","The protein encoded by this gene is a member of the oligameric minichromosome maintenance protein complex. During DNA replication, the complex loads onto chromatin in early G1 and is converted into an active replicative helicase during S phase. It functions to limit DNA synthesis to once per cell cycle. During embryogenesis, the encoded protein is negatively regulated through expression of paired box protein Pax 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
16562a16502
> "Q9QUM7-1","NP_001139687.1","mutS protein homolog 5","833","This gene encodes a member of the MutS family of proteins that play critical roles in DNA mismatch repair and meiotic homologous recombination processes. Mice lacking the encoded protein are viable but sterile, with severe defects in spermatogenesis in males and complete loss of ovarian structures in females. Mutations in a similar gene in humans have been shown to cause common variable immune deficiency (CVID) and immunoglobulin A deficiency. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]. "
16565c16505,16506
< "Q8C0P7-1","NP_598578.1","E3 SUMO-protein ligase ZNF451 isoform 1","1056",""
---
> "O35613-1","NP_001186662.1","death domain-associated protein 6","740",""
> "P56581-1","NP_035691.2","G/T mismatch-specific thymine DNA glycosylase isoform 1","397",""
16568,16570d16508
< "Q64704-1","NP_689344.1","syntaxin-3 isoform A","289",""
< "Q9D074-1","NP_083933.1","E3 ubiquitin-protein ligase MGRN1 isoform 2","532",""
< "O89100-1","NP_034945.1","GRB2-related adaptor protein 2","322",""
16572a16511
> "Q9CQF6-1","NP_001313288.1","L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase isoform 2","255",""
16574c16513
< "Q80ZM7-1","NP_001269012.1","transcription initiation factor IIA subunit 2 isoform 1","109",""
---
> "Q60662-1","NP_001036007.1","A-kinase anchor protein 4 isoform b","840",""
16575a16515
> "Q61702-1","NP_001293007.1","inter-alpha-trypsin inhibitor heavy chain H1 isoform 2 precursor","911","This gene encodes a heavy chain of inter-alpha trypsin inhibitor (IaI) family of plasma serine protease inhibitors. IaI proteins are protein-glycosaminoglycan-protein complexes comprised of two heavy chains and a light chain. The encoded protein covalently associates with the light chain via a chondroitin sulfate moiety. Intravenous administration of the encoded protein improved survival of mice after infection with Escherichia coli. This gene is located adjacent to two other IaI heavy chain genes. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature protein. [provided by RefSeq, Oct 2015]. "
16578c16518,16520
< "Q6PE65-1","NP_081681.2","G patch domain-containing protein 2-like isoform 1","482",""
---
> "Q9CQ44-1","NP_001297025.1","transmembrane protein 218 isoform 1","123",""
> "Q62393-1","NP_001020433.1","tumor protein D52 isoform 2","224",""
> "Q8BRU4-1","NP_001192292.1","C-type lectin domain family 9 member A isoform 1","264",""
16580c16522
< "P49452-1","NP_031709.2","centromere protein C isoform 2","906","This gene encodes a centromeric protein component of a nucleosome-associated complex that plays a central role in kinetochore protein assembly, mitotic progression and chromosome segregation. The human ortholog encodes a protein with DNA-binding activity, that associates constitutively to kinetochores throughout the cell cycle, as part of a prekinetochore complex, together with centromeric protein-A and centromeric protein-B. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. "
---
> "P97368-1","NP_001264917.1","homeobox protein Meis3 isoform b","361","The protein encoding this gene belongs to the three amino acid loop extension family of homeodomain transcription factors, which play essential roles in many embryonic processes. These proteins are characterized by an atypical homeodomain containing a three amino acid loop extension between helices 1 and 2. Expression of this gene begins during the compaction stage of embryogenesis and continues into the blastocyst stage. This gene is also expressed in pancreatic islet cells and beta-cells and regulates beta-cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]. "
16581a16524,16527
> "Q570Y9-1","NP_001033026.1","DEP domain-containing mTOR-interacting protein isoform b","397",""
> "Q9CQ58-1","NP_001303650.1","prolactin-8A9 isoform 2 precursor","240",""
> "Q6NVE8-1","NP_001292604.1","WD repeat-containing protein 44","915","This gene encodes a protein containing multiple WD repeats. The encoded protein may play a role in vesicle trafficking. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]. "
> "Q9D742-1","NP_001277961.1","AP-5 complex subunit sigma-1 isoform c","170",""
16583,16584c16529,16530
< "Q9CPR5-1","NP_079576.1","39S ribosomal protein L15, mitochondrial isoform 2 precursor","204",""
< "Q9D385-1","NP_077231.1","ADP-ribosylation factor-like protein 2-binding protein isoform 2","152",""
---
> "Q9DAY2-1","NP_001258307.1","prolactin-8A6 isoform a precursor","240",""
> "Q99LB6-1","NP_001186203.1","methionine adenosyltransferase 2 subunit beta isoform 2","323",""
16585a16532
> "Q7TN99-1","NP_001277755.1","cytoplasmic polyadenylation element-binding protein 3 isoform a","716",""
16587d16533
< "Q9D7Y9-1","NP_083110.1","protein SLX4IP isoform 1","413",""
16589,16591d16534
< "Q80TY4-1","NP_776293.1","suppression of tumorigenicity 18 protein","1045",""
< "Q3U507-1","NP_001171253.1","probable G-protein coupled receptor 174","335",""
< "Q60662-1","NP_033781.2","A-kinase anchor protein 4 isoform a","849",""
16593a16537
> "Q6ZPR4-1","NP_001289280.1","potassium channel subfamily T member 1 isoform 3","1224","This gene encodes a member of the Slo potassium channel family that has shown to be activated by both sodium and chloride ions. This channel represents the largest potassium channel subunit yet identified. This channel may be important in development and pain signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
16595d16538
< "Q9WTM3-1","NP_035481.1","semaphorin-6C isoform 2 precursor","931",""
16597d16539
< "Q61979-1","NP_851291.1","neuronatin isoform beta","54",""
16599d16540
< "Q9D742-1","NP_081405.2","AP-5 complex subunit sigma-1 isoform a","248",""
16600a16542
> "Q6PFD9-1","NP_001274093.1","nuclear pore complex protein Nup98-Nup96 isoform 1 precursor","1816",""
16602c16544
< "Q8BUR3-1","NP_766287.1","forkhead box protein J3 isoform 1","623",""
---
> "Q1W617-1","NP_001035549.1","protein Shroom4 isoform 1","1475",""
16604d16545
< "Q9CQ44-1","NP_079740.1","transmembrane protein 218 isoform 2","115",""
16606,16607c16547
< "Q9DAY2-1","NP_035297.1","prolactin-8A6 isoform b precursor","239",""
< "Q9D6J6-1","NP_082664.1","NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform 1 precursor","248","This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. This gene is a core subunit and is conserved in prokaryotes and eukaryotes. The bovine ortholog of this protein has been characterized and is reported to contain an iron-sulfur cluster, which may be involved in electron transfer. In humans mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]. "
---
> "Q6PA06-1","NP_062691.3","atlastin-2 isoform 1","583",""
16613c16553
< "Q9D162-1","NP_081058.1","coiled-coil domain-containing protein 167 isoform 2","97",""
---
> "Q9CWR8-1","NP_001075164.1","DNA (cytosine-5)-methyltransferase 3-like isoform 1","421","CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein that is a catalytically inactive regulatory factor of DNA methyltransferases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
16616c16556
< "O08688-1","NP_031628.1","calpain-5","640","The protein encoded by this gene is a member of the calpain family of proteins. Unlike many members of the calpain gene family, this gene lacks a calmodulin-like domain, required for calcium binding. Mouse models for Huntington's disease displayed increased levels of the protein encoded by this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. "
---
> "Q9D752-1","NP_001292349.1","mitotic spindle assembly checkpoint protein MAD2B","211",""
16617a16558
> "Q8C0S1-1","NP_001001295.2","DIS3-like exonuclease 1 isoform 1","1053",""
16620c16561,16565
< "A2BIM8-1","NP_001186262.1","major urinary protein 18 precursor","181",""
---
> "Q60929-1","NP_001028885.1","myocyte-specific enhancer factor 2A isoform a","498",""
> "Q9CW79-1","NP_001277578.1","golgin subfamily A member 1 isoform b","733",""
> "O89100-1","NP_001276371.1","GRB2-related adaptor protein 2","322",""
> "Q8VE22-1","NP_001278199.1","28S ribosomal protein S23, mitochondrial isoform b","158",""
> "Q9D6J6-1","NP_001265344.1","NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform 2","152","This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. This gene is a core subunit and is conserved in prokaryotes and eukaryotes. The bovine ortholog of this protein has been characterized and is reported to contain an iron-sulfur cluster, which may be involved in electron transfer. In humans mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]. "
16622,16624c16567,16569
< "P49650-1","NP_032798.1","P2Y purinoceptor 1","373",""
< "Q64362-1","NP_034371.1","AKT-interacting protein isoform 1","292",""
< "Q8VCF1-1","NP_083778.2","soluble calcium-activated nucleotidase 1 isoform a","403","The protein encoded by this gene is a calcium-dependent nucleotidase that preferentially hydrolyzes UDP, GDP, and IDP. The encoded protein has low activity with ADP and ATP and shows no activity with AMP and GMP. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]. "
---
> "O55040-1","NP_001306156.1","neuromedin-U receptor 1 isoform 1","428",""
> "P49452-1","NP_001332831.1","centromere protein C isoform 1","995","This gene encodes a centromeric protein component of a nucleosome-associated complex that plays a central role in kinetochore protein assembly, mitotic progression and chromosome segregation. The human ortholog encodes a protein with DNA-binding activity, that associates constitutively to kinetochores throughout the cell cycle, as part of a prekinetochore complex, together with centromeric protein-A and centromeric protein-B. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. "
> "B1AY10-1","NP_001277377.1","transcriptional repressor NF-X1 isoform 2","818",""
16626c16571
< "Q570Y9-1","NP_663445.2","DEP domain-containing mTOR-interacting protein isoform a","409",""
---
> "Q8BI67-1","NP_001276765.1","zinc finger protein 473 homolog isoform 1","892",""
16629d16573
< "Q80YE4-1","NP_031403.2","serine/threonine-protein kinase LMTK1 isoform 1","1317",""
16631,16634c16575,16577
< "Q9D662-1","NP_062761.2","protein transport protein Sec23B isoform 1","767",""
< "Q9EP75-1","NP_071879.1","leukotriene-B4 omega-hydroxylase 3","524",""
< "Q9Z131-1","NP_036024.2","SH3 domain-binding protein 5 isoform 1","458",""
< "Q30KP6-1","NP_898947.1","beta-defensin 41 isoform 1 precursor","62",""
---
> "Q01965-1","NP_001264897.1","T-lymphocyte surface antigen Ly-9 isoform 2","544",""
> "O35174-1","NP_001258633.1","potassium voltage-gated channel subfamily S member 2","477",""
> "P48026-1","NP_001278794.1","diamine acetyltransferase 1 isoform 2","96",""
16639,16644c16582,16588
< "Q9QUK4-1","NP_035002.2","baculoviral IAP repeat-containing protein 1b","1447",""
< "Q80ZD8-1","NP_666249.2","amphoterin-induced protein 1 isoform a precursor","492",""
< "Q3SYK4-1","NP_001162061.1","vertnin","740",""
< "Q60775-1","NP_031946.1","ETS-related transcription factor Elf-1 isoform 1","612",""
< "P68433-1","NP_835514.1","histone H3.1","136","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. "
< "Q8R216-1","NP_598521.1","NAD-dependent protein lipoamidase sirtuin-4, mitochondrial","333",""
---
> "Q9ER72-1","NP_001239522.1","cysteine--tRNA ligase, cytoplasmic isoform 2","748",""
> "Q3U507-1","NP_001028423.1","probable G-protein coupled receptor 174","335",""
> "Q6KAQ7-1","NP_001074224.1","ZZ-type zinc finger-containing protein 3 isoform a","910",""
> "Q80U30-1","NP_001191158.1","protein CLEC16A isoform 2","1034",""
> "Q8C5H8-1","NP_001035485.2","NAD kinase 2, mitochondrial isoform 2","430",""
> "P84244-1","NP_032236.1","histone H3.3","136","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Nov 2015]. "
> "Q9D0L4-1","NP_001264225.1","aarF domain-containing protein kinase 1 isoform a precursor","525",""
16647c16591,16592
< "Q9D0L4-1","NP_082381.1","aarF domain-containing protein kinase 1 isoform a precursor","525",""
---
> "P62806-1","NP_001182350.1","histone H4","103","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. "
> "Q8R216-1","NP_001161163.1","NAD-dependent protein lipoamidase sirtuin-4, mitochondrial","333",""
16650d16594
< "P84244-1","NP_032237.1","histone H3.3","136","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. [provided by RefSeq, Nov 2015]. "
16653d16596
< "Q6PIP5-1","NP_080425.3","nudC domain-containing protein 1 isoform 1","582",""
16656c16599
< "P62806-1","NP_835583.1","histone H4","103","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. "
---
> "P68433-1","NP_038578.2","histone H3.1","136","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]. "
16660a16604
> "Q80ZM8-1","NP_001019556.1","cardiolipin synthase (CMP-forming) isoform 1","303",""
16665a16610
> "Q61361-1","NP_001103228.1","brevican core protein isoform 2 precursor","645",""
16667,16668d16611
< "Q61361-1","NP_031555.2","brevican core protein isoform 1 precursor","883",""
< "Q8BHK2-1","NP_839941.1","sodium channel subunit beta-3 isoform a precursor","215",""
16672a16616
> "Q8BHK2-1","NP_001077386.1","sodium channel subunit beta-3 isoform a precursor","215",""
16681d16624
< "P61014-1","NP_075618.1","cardiac phospholamban","52",""
16686a16630
> "Q8K3J9-1","NP_001103808.1","G-protein coupled receptor family C group 5 member C isoform b precursor","440",""
16689d16632
< "Q6PCQ0-1","NP_083109.2","IQ domain-containing protein E isoform 1","778",""
16690a16634
> "Q8BHZ5-1","NP_001129083.1","cell cycle regulator of non-homologous end joining isoform 1","157",""
16695d16638
< "Q8VC19-1","NP_065584.2","5-aminolevulinate synthase, nonspecific, mitochondrial precursor","642",""
16701d16643
< "O88968-1","NP_056564.1","transcobalamin-2 precursor","430",""
16708a16651
> "P18872-1","NP_001106855.1","guanine nucleotide-binding protein G(o) subunit alpha isoform B","354",""
16711d16653
< "Q61087-1","NP_032510.2","laminin subunit beta-3 precursor","1168",""
16713d16654
< "Q9R0N7-1","NP_775091.2","synaptotagmin-7 isoform gamma","567",""
16715c16656
< "Q9WUB7-1","NP_077723.3","chloride channel protein ClC-Ka","687","This gene is a member of the CLC family of voltage-gated chloride channels. The gene is located adjacent to a highly similar chloride channel gene on chromosome 4. This gene is syntenic with human CLCNKB (geneID:1188). Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Sep 2009]. "
---
> "Q3UR50-1","NP_001138425.1","von Willebrand factor A domain-containing protein 5B2 isoform 1","1248",""
16718d16658
< "P42232-1","NP_035619.3","signal transducer and activator of transcription 5B","786",""
16721,16722c16661
< "Q8VC90-1","NP_079704.2","probable palmitoyltransferase ZDHHC12 isoform a","281",""
< "Q80XC3-1","NP_852064.2","USP6 N-terminal-like protein isoform a","842",""
---
> "Q9D868-1","NP_001103599.1","peptidyl-prolyl cis-trans isomerase H isoform 1","177",""
16725d16663
< "Q91VB4-1","NP_542365.3","Hermansky-Pudlak syndrome 3 protein homolog isoform 1","1002",""
16732,16733c16670
< "Q9Z307-1","NP_034734.3","inward rectifier potassium channel 16","419",""
< "P28574-1","NP_001139648.1","protein max isoform 2","151",""
---
> "P28574-1","NP_032584.2","protein max isoform 1","160",""
16738,16740c16675
< "Q5XG69-1","NP_001139517.1","soluble lamin-associated protein of 75 kDa","665",""
< "Q05117-1","NP_031414.1","tartrate-resistant acid phosphatase type 5 precursor","327",""
< "P57722-1","NP_067543.2","poly(rC)-binding protein 3 isoform 1","371",""
---
> "P61237-1","NP_079623.1","protein yippee-like 3","119",""
16743a16679
> "P97372-1","NP_001025026.1","proteasome activator complex subunit 2 isoform 2","231",""
16745d16680
< "Q8C7W7-1","NP_598626.2","5' exonuclease Apollo isoform a","541",""
16749a16685
> "Q2TV84-1","NP_001034193.2","transient receptor potential cation channel subfamily M member 1 isoform 2","1622",""
16751a16688
> "Q3UFB2-1","NP_001074563.1","box C/D snoRNA protein 1 isoform 1","460",""
16754a16692
> "Q9CQX6-1","NP_001033697.2","thioredoxin-like protein 4A isoform b","63",""
16756d16693
< "Q80TJ7-1","NP_796175.1","histone lysine demethylase PHF8 isoform a","795",""
16758d16694
< "Q07563-1","NP_031758.2","collagen alpha-1(XVII) chain isoform 2","1433",""
16760d16695
< "Q9QZZ4-1","NP_874357.2","unconventional myosin-XV isoform 2a","2306",""
16762a16698
> "O88968-1","NP_001123930.1","transcobalamin-2 precursor","430",""
16768d16703
< "Q61595-1","NP_032503.2","kinectin isoform 1","1327",""
16771a16707
> "Q9CWV4-1","NP_001107206.1","melanoma-associated antigen B16","363",""
16785d16720
< "Q8BGY4-1","NP_848886.1","kelch-like protein 26 isoform 2","606",""
16788d16722
< "P42703-1","NP_038612.1","leukemia inhibitory factor receptor isoform 1 precursor","1092",""
16797d16730
< "Q80U04-1","NP_659108.1","E3 ubiquitin-protein ligase Praja-2 isoform b","645",""
16805a16739,16740
> "Q91ZD6-1","NP_001106872.1","ELL-associated factor 2 isoform b","262",""
> "Q80U04-1","NP_001020480.1","E3 ubiquitin-protein ligase Praja-2 isoform a","707",""
16811d16745
< "Q9QVY8-1","NP_940801.2","retinoic acid-induced protein 2","529",""
16818,16819d16751
< "Q69ZK7-1","NP_705812.2","protein FAM214A isoform 2","1082",""
< "Q8BG09-1","NP_766196.1","transmembrane protein 184B isoform 1","407",""
16821d16752
< "O54792-1","NP_032262.2","transcription factor HES-2","157","The protein encoded by this gene belongs to the mammalian Hes gene family, the mammalian homologues of Drosophila hairy and Enhancer of split. Hes 2 is a basic helix-loop-helix transcriptional repressor and is an effector of the Notch signaling pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. "
16824,16825d16754
< "Q8R2P1-1","NP_877583.1","kelch-like protein 25","589",""
< "Q8VCY8-1","NP_659184.1","phospholipid phosphatase-related protein type 2 isoform 1","343",""
16828a16758
> "Q8BGY4-1","NP_001116302.1","kelch-like protein 26 isoform 3","545",""
16829a16760
> "Q8BZJ7-1","NP_001019675.2","DCN1-like protein 2 isoform a","259",""
16834d16764
< "Q5FWK3-1","NP_666236.3","rho GTPase-activating protein 1 isoform 2","439",""
16844,16845d16773
< "Q9CQX6-1","NP_848719.2","thioredoxin-like protein 4A isoform b","63",""
< "P97764-1","NP_058037.2","WW domain-binding protein 1 isoform 1","304",""
16852,16854c16780
< "Q9CW73-1","NP_084068.1","galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform 2","334",""
< "Q8CGA2-1","NP_598671.3","TBC1 domain family member 14 isoform b","694",""
< "O08715-1","NP_033778.2","A-kinase anchor protein 1, mitochondrial","857",""
---
> "Q99LG2-1","NP_001116315.1","transportin-2 isoform 1","897",""
16857d16782
< "Q6X1Y6-1","NP_892045.2","acid-sensing ion channel 3 isoform 1","530",""
16859c16784
< "Q2TV84-1","NP_061222.3","transient receptor potential cation channel subfamily M member 1 isoform 1","542",""
---
> "Q9WUB0-1","NP_001077390.1","ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform a","508",""
16866d16790
< "P18872-1","NP_034438.1","guanine nucleotide-binding protein G(o) subunit alpha isoform A","354",""
16867a16792,16793
> "Q91VB4-1","NP_001139795.1","Hermansky-Pudlak syndrome 3 protein homolog isoform 2","870",""
> "Q8CGA2-1","NP_001106833.1","TBC1 domain family member 14 isoform a","714",""
16869a16796
> "Q80XC3-1","NP_001074017.1","USP6 N-terminal-like protein isoform b","819",""
16872a16800
> "Q8VC90-1","NP_001032851.1","probable palmitoyltransferase ZDHHC12 isoform b","267",""
16876c16804,16805
< "Q9WUG6-1","NP_035961.1","insulin-like peptide INSL5 isoform 2 precursor","135",""
---
> "P52624-1","NP_001152873.1","uridine phosphorylase 1","311",""
> "Q05117-1","NP_001095874.1","tartrate-resistant acid phosphatase type 5 precursor","327",""
16878a16808
> "Q9WUB7-1","NP_001139779.1","chloride channel protein ClC-Ka","687","This gene is a member of the CLC family of voltage-gated chloride channels. The gene is located adjacent to a highly similar chloride channel gene on chromosome 4. This gene is syntenic with human CLCNKB (geneID:1188). Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Sep 2009]. "
16882d16811
< "O88689-1","NP_031792.1","protocadherin alpha-4 precursor","947",""
16886a16816
> "P42703-1","NP_001106857.1","leukemia inhibitory factor receptor isoform 2 precursor","719",""
16888a16819
> "Q62296-1","NP_001074448.2","transcriptional enhancer factor TEF-3 isoform b","384","This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. This factor may play a role in the embryonic development of skeletal muscle. Alternatively spliced transcripts encoding distinct isoforms, which are translated through the use of a non-AUG (AUU) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]. "
16890c16821
< "O55042-1","NP_033247.1","alpha-synuclein","140",""
---
> "Q5FWK3-1","NP_001139374.1","rho GTPase-activating protein 1 isoform 1","479",""
16892,16894c16823
< "P22726-1","NP_033551.2","protein Wnt-5b precursor","359",""
< "Q3UR50-1","NP_872574.2","von Willebrand factor A domain-containing protein 5B2 isoform 2","602",""
< "Q9Z1P5-1","NP_062294.3","CD320 antigen isoform 1 precursor","260",""
---
> "Q61144-1","NP_001122077.1","presenilin-2","448","This gene encodes a member of the presenilin family. Presenilins are catalytic components of the multi-subunit gamma-secretase complex, which mediates critical cellular processes through cleavage of type I transmembrane proteins including Notch receptors and the amyloid precursor protein. The encoded protein contains eight transmembrane domains and is localized to the endoplasmic reticulum, where it may play a role in calcium homeostasis. Following assembly of the gamma-secretase complex, the encoded protein is cleaved into N- and C-terminal fragments and the activated complex is released from the endoplasmic reticulum. Inactivation of this gene results in impaired synaptic function in a mouse model for Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2011]. "
16902d16830
< "B0V2N1-1","NP_035348.2","receptor-type tyrosine-protein phosphatase S isoform 1 precursor","1907",""
16905d16832
< "Q7TPN3-1","NP_848813.3","GPI mannosyltransferase 2 isoform 1","493",""
16912,16913c16839
< "O54916-1","NP_033074.2","ralBP1-associated Eps domain-containing protein 1 isoform 1","795",""
< "Q8VIK5-1","NP_690012.2","platelet endothelial aggregation receptor 1 isoform a precursor","1034",""
---
> "Q8CAE2-1","NP_001072114.1","small RNA 2'-O-methyltransferase","395",""
16919d16844
< "Q62296-1","NP_035697.3","transcriptional enhancer factor TEF-3 isoform a","427","This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. This factor may play a role in the embryonic development of skeletal muscle. Alternatively spliced transcripts encoding distinct isoforms, which are translated through the use of a non-AUG (AUU) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]. "
16922a16848
> "P63013-1","NP_035257.1","paired mesoderm homeobox protein 1 isoform a","245",""
16928d16853
< "O88587-1","NP_031770.2","catechol O-methyltransferase","265",""
16930a16856
> "Q8CC21-1","NP_082636.3","tetratricopeptide repeat protein 19, mitochondrial isoform 1","365",""
16935d16860
< "P25801-1","NP_001135809.1","rhombotin-2 isoform 3","158",""
16937,16938d16861
< "Q9D552-1","NP_083343.1","spermatogenesis-associated protein 17 isoform 2","192",""
< "Q9WUB0-1","NP_062679.2","ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform a","508",""
16939a16863
> "Q69ZK7-1","NP_001106754.1","protein FAM214A isoform 1","1075",""
16942a16867
> "Q4U4S6-1","NP_001019789.1","xin actin-binding repeat-containing protein 2 isoform 1","3784",""
16944d16868
< "Q91ZD6-1","NP_598872.1","ELL-associated factor 2 isoform a","132",""
16945a16870
> "Q8VIK5-1","NP_001027585.1","platelet endothelial aggregation receptor 1 isoform a precursor","1034",""
16947a16873
> "Q9R0N7-1","NP_061271.1","synaptotagmin-7 isoform alpha","403",""
16950c16876,16877
< "Q3THF9-1","NP_080700.3","coenzyme Q-binding protein COQ10 homolog B, mitochondrial isoform 2","192",""
---
> "Q5XG69-1","NP_001093928.1","soluble lamin-associated protein of 75 kDa","665",""
> "Q9D3U0-1","NP_001028826.1","putative tRNA pseudouridine synthase Pus10","527",""
16953d16879
< "P55099-1","NP_033338.2","tachykinin-3 preproprotein","116","This gene encodes a member of the tachykinin family of signaling peptides that is widely expressed in the central nervous system and plays a role in diverse processes such as water homeostasis, pulmonary inflammation, cognition, fear memory consolidation and preeclampsia. The encoded protein is enzymatically processed to generate the mature neuropeptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]. "
16955d16880
< "Q3V1T4-1","NP_062757.2","prolyl 3-hydroxylase 1 isoform 2 precursor","739",""
16962c16887,16888
< "Q8R4E6-1","NP_690034.1","purine-rich element-binding protein gamma isoform a","350",""
---
> "Q7TPN3-1","NP_001139427.1","GPI mannosyltransferase 2 isoform 2","211",""
> "Q3THF9-1","NP_001034799.1","coenzyme Q-binding protein COQ10 homolog B, mitochondrial isoform 1","242",""
16977,16979c16903,16905
< "O09012-1","NP_787947.1","peroxisomal targeting signal 1 receptor isoform 2","602",""
< "A2A935-1","NP_081780.3","histone-lysine N-methyltransferase PRDM16 isoform 1","1275",""
< "P35235-1","NP_035332.1","tyrosine-protein phosphatase non-receptor type 11 isoform a","597",""
---
> "Q91WD4-1","NP_001098116.1","UPF0415 protein C7orf25 homolog","421",""
> "Q9R007-3","NP_001033693.1","C-type lectin domain family 5 member A isoform 1","190",""
> "Q8BWW4-1","NP_001019697.2","la-related protein 4 isoform 1","719",""
16982d16907
< "Q8BH48-1","NP_075794.3","ubiquitin-associated protein 1 isoform 1","502",""
16983a16909
> "Q8VCI5-1","NP_001152997.1","peroxisomal biogenesis factor 19 isoform b","207",""
16989,16990d16914
< "P63013-1","NP_783617.2","paired mesoderm homeobox protein 1 isoform b","217",""
< "Q8BHZ5-1","NP_954596.1","cell cycle regulator of non-homologous end joining isoform 1","157",""
16996d16919
< "Q9CQA0-1","NP_840000.2","centromere protein M isoform 2","168","This gene encodes a protein that is present in the nucleus of actively growing cells but is excluded from the nucleus during cell division or during growth arrest as a result of contact inhibition. In human, this protein is a component of the CENP-A nucleosome-associated complex that regulates kinetochore protein assembly, mitotic cell-cycle progression, and chromosome segregation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. "
16998d16920
< "Q8K3J9-1","NP_671750.2","G-protein coupled receptor family C group 5 member C isoform b precursor","440",""
16999a16922,16923
> "P97764-1","NP_001077392.1","WW domain-binding protein 1 isoform 3","269",""
> "Q811G0-1","NP_848502.1","protein PTHB1 isoform 1","880",""
17003d16926
< "Q9JHE7-1","NP_064681.1","protein TSSC4 isoform 1","317",""
17007d16929
< "Q8BND3-1","NP_766058.3","WD repeat-containing protein 35 isoform 1","1181",""
17012d16933
< "Q9D3U0-1","NP_083232.1","putative tRNA pseudouridine synthase Pus10","527",""
17024d16944
< "P61237-1","NP_081151.2","protein yippee-like 3","119",""
17036a16957
> "O08715-1","NP_001036006.1","A-kinase anchor protein 1, mitochondrial","857",""
17042,17043c16963,16964
< "Q8BH35-1","NP_598643.1","complement component C8 beta chain isoform 1 preproprotein","589","This gene encodes the beta subunit of complement component C8 that participates in the assembly of the complement membrane attack complex. The encoded preproprotein undergoes proteolytic processing to generate the beta subunit, which associates with the alpha and gamma subunits to form a trimeric complement component, C8. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. This gene is located adjacent to the gene encoding the alpha subunit. [provided by RefSeq, Oct 2015]. "
< "Q91WD4-1","NP_598828.3","UPF0415 protein C7orf25 homolog","421",""
---
> "Q9JHY4-1","NP_001039019.1","WAP four-disulfide core domain protein 15B precursor","80",""
> "Q9D552-1","NP_083124.1","spermatogenesis-associated protein 17 isoform 1","379",""
17050d16970
< "Q80ZM8-1","NP_079922.2","cardiolipin synthase (CMP-forming) isoform 2","188",""
17052a16973
> "Q9Z2X8-1","NP_001103775.1","kelch-like ECH-associated protein 1","624",""
17054d16974
< "Q02788-1","NP_666119.1","collagen alpha-2(VI) chain isoform 1 precursor","1034",""
17059d16978
< "O88507-1","NP_057882.2","ciliary neurotrophic factor receptor subunit alpha preproprotein","372","This gene encodes the alpha subunit of the ciliary neurotrophic factor (CNTF) receptor that triggers the assembly of a trimolecular complex upon binding to CNTF, and initiate a downstream signaling process. The encoded preproprotein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-linked cell surface protein. Mice lacking the encoded protein die shortly after birth and exhibit a reduction of motoneuron number at birth. The transgenic disruption of this gene specifically in the skeletal muscle followed by a peripheral nerve lesion impairs motor neuron axonal regeneration across the lesion site. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2015]. "
17064c16983
< "P97372-1","NP_035320.1","proteasome activator complex subunit 2 isoform 1","239",""
---
> "Q8C7W7-1","NP_001020483.1","5' exonuclease Apollo isoform b","415",""
17069d16987
< "Q3UA37-1","NP_780352.2","glutamine-rich protein 1","777",""
17074d16991
< "Q99LG2-1","NP_663365.3","transportin-2 isoform 1","897",""
17077a16995
> "Q9QZZ4-1","NP_001096641.1","unconventional myosin-XV isoform 3","3493",""
17084a17003
> "O54916-1","NP_001104535.1","ralBP1-associated Eps domain-containing protein 1 isoform 2","768",""
17088d17006
< "Q7TN33-1","NP_780444.2","CUGBP Elav-like family member 6 isoform 1","460",""
17092d17009
< "Q8CAE2-1","NP_079999.2","small RNA 2'-O-methyltransferase","395",""
17096d17012
< "Q9JHY4-1","NP_619626.1","WAP four-disulfide core domain protein 15B precursor","80",""
17099c17015
< "Q9CWV4-1","NP_082301.1","melanoma-associated antigen B16","363",""
---
> "Q9JHE7-1","NP_001108557.1","protein TSSC4 isoform 1","317",""
17102a17019
> "Q3V1T4-1","NP_001035874.1","prolyl 3-hydroxylase 1 isoform 3","560",""
17104d17020
< "Q9R007-3","NP_067339.1","C-type lectin domain family 5 member A isoform 2","165",""
17105a17022
> "Q8R4E6-1","NP_001091703.1","purine-rich element-binding protein gamma isoform b","325",""
17109d17025
< "O08650-1","NP_032243.2","hyaluronan synthase 3","554",""
17111d17026
< "Q8VCI5-1","NP_075528.3","peroxisomal biogenesis factor 19 isoform a","299",""
17115d17029
< "Q9D868-1","NP_082953.1","peptidyl-prolyl cis-trans isomerase H isoform 1","177",""
17125a17040
> "P61014-1","NP_001135399.1","cardiac phospholamban","52",""
17133d17047
< "Q811G0-1","NP_851833.2","protein PTHB1 isoform 1","880",""
17138d17051
< "Q9Z2X8-1","NP_057888.1","kelch-like ECH-associated protein 1","624",""
17140a17054
> "O88587-1","NP_001104532.1","catechol O-methyltransferase","265",""
17147a17062
> "P35235-1","NP_001103462.1","tyrosine-protein phosphatase non-receptor type 11 isoform b","593",""
17153a17069
> "Q8VC70-1","NP_001034169.1","RNA-binding motif, single-stranded-interacting protein 2 isoform b","355",""
17156d17071
< "Q8VC70-1","NP_062685.2","RNA-binding motif, single-stranded-interacting protein 2 isoform a","383",""
17157a17073
> "Q9CQA0-1","NP_001073627.1","centromere protein M isoform 3","146","This gene encodes a protein that is present in the nucleus of actively growing cells but is excluded from the nucleus during cell division or during growth arrest as a result of contact inhibition. In human, this protein is a component of the CENP-A nucleosome-associated complex that regulates kinetochore protein assembly, mitotic cell-cycle progression, and chromosome segregation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. "
17159c17075,17076
< "P52624-1","NP_033503.2","uridine phosphorylase 1","311",""
---
> "P25801-1","NP_001135808.1","rhombotin-2 isoform 3","158",""
> "Q3UA37-1","NP_001107591.1","glutamine-rich protein 1","777",""
17162d17078
< "Q8K387-1","NP_690038.1","ubiquitin carboxyl-terminal hydrolase 45 isoform 1","813",""
17163a17080
> "Q8R2P1-1","NP_001116252.1","kelch-like protein 25","589",""
17170a17088
> "Q9D662-1","NP_001239472.1","protein transport protein Sec23B isoform 1","767",""
17171a17090
> "B2RXS4-1","NP_001152993.1","plexin-B2 precursor","1842",""
17172a17092
> "Q8R0A7-1","NP_001157232.1","uncharacterized protein KIAA0513 isoform a","407",""
17174c17094
< "Q9QZ05-1","NP_038747.2","eIF-2-alpha kinase GCN2 isoform 1","1648",""
---
> "Q9CYC3-1","NP_001192215.1","transmembrane protein 39A isoform 1","486",""
17183,17184c17103
< "Q8BQU6-1","NP_780661.2","gap junction gamma-2 protein","440",""
< "O09116-1","NP_035608.1","small proline-rich protein 3","238",""
---
> "Q9Z0Z4-1","NP_001153099.1","hephaestin isoform 1 precursor","1157",""
17186,17188c17105
< "Q09200-1","NP_082015.2","beta-1,4 N-acetylgalactosaminyltransferase 1 isoform 2","569",""
< "Q9D7S1-1","NP_079728.2","transmembrane protein 54 isoform 1","219",""
< "Q9Z2P8-1","NP_058568.1","vesicle-associated membrane protein 5","102",""
---
> "Q9D0U6-1","NP_001158079.1","repressor of RNA polymerase III transcription MAF1 homolog","258",""
17190d17106
< "P70225-1","NP_034680.3","interleukin-11 receptor subunit alpha-2 precursor","432",""
17193c17109
< "Q9ESD6-1","NP_598739.1","CKLF-like MARVEL transmembrane domain-containing protein 7 isoform 1","167",""
---
> "Q8CBR6-1","NP_001019790.1","tsukushin precursor","354",""
17195a17112
> "Q91VM5-1","NP_001239018.1","RNA binding motif protein, X-linked-like-1","388",""
17198c17115,17117
< "Q9EQR6-1","NP_444311.1","Fanconi anemia group G protein homolog isoform 1","623",""
---
> "Q6NWV3-1","NP_001161235.1","intraflagellar transport protein 122 homolog isoform 2","1182",""
> "Q9D1N4-1","NP_001153074.1","protein myomaker isoform 2","180",""
> "Q9Z275-1","NP_001166954.1","retinaldehyde-binding protein 1","317",""
17207,17210c17126
< "Q99JR5-1","NP_075965.2","tubulointerstitial nephritis antigen-like precursor","466",""
< "Q8BMQ2-1","NP_766565.2","general transcription factor 3C polypeptide 4 isoform 1","817",""
< "Q8BZN4-1","NP_083054.1","NUAK family SNF1-like kinase 2 isoform B","631",""
< "Q5U4D8-1","NP_808538.1","sodium-dependent multivitamin transporter","634",""
---
> "Q8BHD7-1","NP_659153.2","polypyrimidine tract-binding protein 3 isoform 1","551",""
17213,17214d17128
< "P06800-4","NP_035340.3","receptor-type tyrosine-protein phosphatase C isoform 2 precursor","1154",""
< "Q9DCP2-1","NP_076294.2","sodium-coupled neutral amino acid transporter 3","505",""
17219d17132
< "Q9ER72-1","NP_038770.3","cysteine--tRNA ligase, cytoplasmic isoform 1","831",""
17221a17135
> "Q69Z61-1","NP_001157703.1","PWWP domain-containing protein 2A isoform a","533",""
17225c17139,17140
< "Q9R2B6-1","NP_035503.1","alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase","302",""
---
> "P0C605-1","NP_001013855.1","cGMP-dependent protein kinase 1 isoform alpha","671",""
> "P55099-1","NP_001186900.1","tachykinin-3 preproprotein","116","This gene encodes a member of the tachykinin family of signaling peptides that is widely expressed in the central nervous system and plays a role in diverse processes such as water homeostasis, pulmonary inflammation, cognition, fear memory consolidation and preeclampsia. The encoded protein is enzymatically processed to generate the mature neuropeptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]. "
17226a17142
> "Q8BG94-1","NP_001182319.1","COMM domain-containing protein 7 isoform 2","129",""
17229d17144
< "Q8R3P6-1","NP_780362.2","integrator complex subunit 14","515",""
17232a17148
> "Q8BYC6-1","NP_001074777.1","serine/threonine-protein kinase TAO3","898",""
17234c17150
< "Q9EQG9-1","NP_075909.1","ceramide transfer protein isoform 1","624",""
---
> "O70281-1","NP_001123948.1","protein-tyrosine sulfotransferase 1","370",""
17240,17242c17156
< "Q08351-1","NP_034953.2","thrombopoietin receptor isoform 2 precursor","625",""
< "Q8CI75-1","NP_705758.1","DIS3-like exonuclease 2 isoform 2","870",""
< "Q64448-1","NP_058671.2","gap junction alpha-3 protein precursor","417",""
---
> "Q9WTW2-1","NP_001177798.1","potassium voltage-gated channel subfamily E member 3","103",""
17243a17158,17159
> "Q8CCN5-1","NP_001160114.1","breast carcinoma-amplified sequence 3 homolog isoform b","913",""
> "Q80W88-1","NP_001171176.1","homeobox and leucine zipper protein Homez","518",""
17245,17246d17160
< "Q9QXL2-1","NP_057914.2","kinesin-like protein KIF21A isoform 3","1573",""
< "Q99PN3-1","NP_001273656.1","tripartite motif-containing protein 26","545",""
17248,17249c17162,17163
< "O88712-1","NP_038530.1","C-terminal-binding protein 1 isoform 3","441",""
< "Q9CR48-1","NP_080289.1","DNA damage-regulated autophagy modulator protein 2 isoform 2","267",""
---
> "Q9D4V4-1","NP_081537.1","TATA box-binding protein-associated factor RNA polymerase I subunit D isoform 3","290",""
> "Q80ZM7-1","NP_001034608.1","transcription initiation factor IIA subunit 2 isoform 1","109",""
17250a17165
> "Q8C0C4-1","NP_001157788.1","serine-rich coiled-coil domain-containing protein 1","895",""
17251a17167
> "Q9CZT4-1","NP_001157568.1","DNA-directed RNA polymerase III subunit RPC5 isoform 2","684",""
17252a17169
> "P22726-1","NP_001258686.1","protein Wnt-5b precursor","359",""
17256d17172
< "Q8CC84-1","NP_780424.1","lysM and putative peptidoglycan-binding domain-containing protein 4 isoform A","293",""
17258a17175
> "Q9CQV7-1","NP_001021382.1","mitochondrial import inner membrane translocase subunit TIM14 isoform 2","157",""
17261,17262c17178
< "Q8R3P2-1","NP_076231.1","probable E3 ubiquitin-protein ligase DTX2 isoform 2","618",""
< "Q11131-1","NP_038552.1","alpha-(1,3)-fucosyltransferase 7 isoform a","342",""
---
> "Q60665-1","NP_001034179.1","ski-like protein isoform b","629","This gene encodes a member of a small family of proteins that play a key role in the response of cells to extracellular growth signals. The encoded protein regulates members of the transforming growth factor beta signaling pathway. It is highly expressed in certain cancer cells, where it may have both tumor-suppressing and tumor-promoting roles. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]. "
17265d17180
< "Q9DCW2-1","NP_032906.2","phospholipid scramblase 2","307",""
17268,17269d17182
< "Q8C166-1","NP_733469.1","copine-1","536","This gene encodes a protein that contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Its activity is also upregulated in mouse embryos. This gene and the gene for RNA binding motif protein 12 overlap at map location 2 H2. Two alternatively spliced variants that encode the same isoform have been identified for this gene. [provided by RefSeq, Jul 2008]. "
< "Q80VY2-1","NP_780607.2","PAK4-inhibitor INKA2 isoform 1","300",""
17272a17186
> "P52480-1","NP_001240812.1","pyruvate kinase PKM isoform M1","531",""
17275a17190,17191
> "Q91YJ5-1","NP_001269047.1","translation initiation factor IF-2, mitochondrial isoform 1 precursor","727",""
> "Q7TMY4-1","NP_001272709.1","THO complex subunit 7 homolog isoform 3","152",""
17277c17193
< "Q9WTP6-1","NP_058591.2","adenylate kinase 2, mitochondrial isoform b","232",""
---
> "Q9CR83-1","NP_001153107.1","probable RNA-binding protein 18 isoform 2","160",""
17281d17196
< "Q8C0S1-1","NP_766107.1","DIS3-like exonuclease 1 isoform 2","970",""
17284d17198
< "P33534-1","NP_035141.1","kappa-type opioid receptor isoform 1","380","This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]. "
17286,17287d17199
< "Q64338-3","NP_035184.1","calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform a","654",""
< "Q8BRH3-1","NP_081943.2","rho GTPase-activating protein 19 isoform 1","494",""
17290,17291c17202
< "Q9QYB5-1","NP_038786.2","gamma-adducin isoform a","706",""
< "Q9D772-1","NP_082269.2","protein FAM219A isoform 2","157",""
---
> "Q80ZD8-1","NP_001004293.1","amphoterin-induced protein 1 isoform a precursor","492",""
17293d17203
< "P41242-1","NP_034898.1","megakaryocyte-associated tyrosine-protein kinase isoform 1","505",""
17295,17296c17205
< "Q8BYC6-1","NP_899129.2","serine/threonine-protein kinase TAO3","898",""
< "Q9CZN7-1","NP_082506.1","serine hydroxymethyltransferase, mitochondrial isoform 1","504",""
---
> "Q3TTE0-1","NP_001258986.1","disintegrin and metalloproteinase domain-containing protein 5 isoform 2 precursor","699","This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of related ADAM genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]. "
17298a17208
> "Q7TPS5-1","NP_001103158.1","C2 domain-containing protein 5 isoform 3","990",""
17304a17215,17216
> "Q9D0B6-1","NP_001268800.1","protein PBDC1 isoform 2","137",""
> "A2AB59-1","NP_001192165.1","rho GTPase-activating protein 27 isoform 1","869",""
17305a17218,17219
> "Q8BTY8-1","NP_001108132.1","sec1 family domain-containing protein 2 isoform a","684",""
> "Q5RKR3-1","NP_001155007.1","immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform a","789",""
17307c17221
< "Q9WTW2-1","NP_065599.1","potassium voltage-gated channel subfamily E member 3","103",""
---
> "Q8BZN4-1","NP_001181954.1","NUAK family SNF1-like kinase 2 isoform A","639",""
17310d17223
< "Q8C9X6-1","NP_081773.1","enhancer of polycomb homolog 1 isoform 2","813",""
17312,17313d17224
< "P28231-1","NP_032152.1","gap junction beta-3 protein","270",""
< "P97329-1","NP_033030.1","kinesin-like protein KIF20A","887",""
17314a17226,17228
> "Q8R3P2-1","NP_001243025.1","probable E3 ubiquitin-protein ligase DTX2 isoform 1","619",""
> "O09126-1","NP_001268809.1","semaphorin-4D precursor","861",""
> "Q501J7-1","NP_001155269.1","phosphatase and actin regulator 4 isoform 2","667",""
17315a17230
> "Q9Z0H0-1","NP_001258495.1","cell division cycle 7-related protein kinase isoform 1","564",""
17317a17233,17234
> "Q8BY35-1","NP_001153010.1","FYVE, RhoGEF and PH domain-containing protein 2 isoform 1","656",""
> "Q80YE4-1","NP_001185714.1","serine/threonine-protein kinase LMTK1 isoform 2 precursor","1374",""
17319c17236,17237
< "Q80XB4-1","NP_932307.2","nebulin-related-anchoring protein isoform C","1693",""
---
> "P20029-1","NP_001156906.1","endoplasmic reticulum chaperone BiP precursor","655",""
> "P50615-1","NP_001284676.1","protein BTG3","252","This gene encodes B cell translocation gene 3, a member of the BTG gene family. This family is defined by a conserved N-terminal domain, known to bind transcription factors, and a less conserved C-terminal domain. This protein is thought to have anti-proliferative properties, and may be involved in regulating the G1-S transition to suppress cell cycle progression. Mice deficient for this gene display an increased incidence of lung cancers, and many human lung cancer cells exhibit decreased levels of B cell translocation gene 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 17. [provided by RefSeq, Jul 2014]. "
17321d17238
< "Q61144-1","NP_035313.2","presenilin-2","448","This gene encodes a member of the presenilin family. Presenilins are catalytic components of the multi-subunit gamma-secretase complex, which mediates critical cellular processes through cleavage of type I transmembrane proteins including Notch receptors and the amyloid precursor protein. The encoded protein contains eight transmembrane domains and is localized to the endoplasmic reticulum, where it may play a role in calcium homeostasis. Following assembly of the gamma-secretase complex, the encoded protein is cleaved into N- and C-terminal fragments and the activated complex is released from the endoplasmic reticulum. Inactivation of this gene results in impaired synaptic function in a mouse model for Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2011]. "
17324c17241
< "Q0VGY8-1","NP_938036.2","protein TANC1 isoform a","1856",""
---
> "Q64448-1","NP_001258552.1","gap junction alpha-3 protein precursor","417",""
17326c17243,17245
< "P28310-1","NP_031876.1","alpha-defensin 3 precursor","93",""
---
> "Q9Z2P8-1","NP_001074211.1","vesicle-associated membrane protein 5","102",""
> "Q8BQU6-1","NP_536702.3","gap junction gamma-2 protein","440",""
> "P54830-1","NP_001157037.1","tyrosine-protein phosphatase non-receptor type 5","541",""
17327a17247,17248
> "P49650-1","NP_001268945.1","P2Y purinoceptor 1","373",""
> "P59438-1","NP_001005247.2","Hermansky-Pudlak syndrome 5 protein homolog isoform 1","1126",""
17329,17330c17250,17252
< "Q91ZQ1-1","NP_291092.1","cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform 1","861",""
< "P41778-1","NP_899198.1","pre-B-cell leukemia transcription factor 1 isoform a","430","This gene encodes a homeobox protein that belongs to the three-amino-acid loop extension/Pre-B cell leukemia transcription factor (TALE/PBX) family of proteins. The encoded protein is involved in several biological processes during embryogenesis including steroidogenesis, sexual development and the maintenance of hematopoietic stem cells. This protein functions in the development of several organ systems and plays a role in skeletal patterning and programming. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]. "
---
> "P97329-1","NP_001159878.1","kinesin-like protein KIF20A","887",""
> "Q9D7S1-1","NP_001277635.1","transmembrane protein 54 isoform 3","205",""
> "P06800-4","NP_001104786.2","receptor-type tyrosine-protein phosphatase C isoform 1 precursor","1293",""
17333a17256
> "Q91ZZ5-1","NP_001276493.1","relaxin receptor 2 isoform 2 precursor","713",""
17340a17264
> "Q9R2B6-1","NP_001263354.1","alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase","302",""
17342,17343c17266
< "Q80W99-1","NP_084048.1","cation channel sperm-associated protein 3 isoform 2","382",""
< "Q9DCK3-1","NP_444312.1","tetraspanin-4","238",""
---
> "Q8CBQ5-1","NP_080227.2","phosphatidylinositol 4-kinase type 2-beta isoform 1","469",""
17344a17268,17269
> "Q9QXL2-1","NP_001102510.1","kinesin-like protein KIF21A isoform 1","1672",""
> "Q9QYB5-1","NP_001157571.1","gamma-adducin isoform a","706",""
17347c17272,17273
< "Q7TSE6-1","NP_766322.1","serine/threonine-protein kinase 38-like isoform 1","464",""
---
> "Q8BRH3-1","NP_001156967.1","rho GTPase-activating protein 19 isoform 2","479",""
> "Q8BTF8-1","NP_001156800.1","RNA-binding Raly-like protein isoform a","293",""
17349d17274
< "P58269-1","NP_478119.1","zinc finger protein DPF3 isoform 3","356",""
17351d17275
< "Q8BG94-1","NP_598611.2","COMM domain-containing protein 7 isoform 1","200",""
17353d17276
< "Q99J78-1","NP_473387.1","differentially expressed in FDCP 8 isoform 3","448",""
17354a17278
> "Q99PQ2-1","NP_001277917.1","E3 ubiquitin-protein ligase TRIM11 isoform 1","483",""
17358d17281
< "Q5UAK0-3","NP_081972.2","mesoderm induction early response protein 1 isoform a precursor","528",""
17360a17284
> "Q6NV72-1","NP_001164329.1","WD repeat and coiled-coil-containing protein isoform 1","663",""
17362,17363c17286,17287
< "Q8VCD7-1","NP_659036.1","lysine-specific demethylase 4C isoform 1","1054",""
< "Q99LB6-1","NP_598778.1","methionine adenosyltransferase 2 subunit beta isoform 1","334",""
---
> "B0V2N1-1","NP_001239382.1","receptor-type tyrosine-protein phosphatase S isoform 2 precursor","1501",""
> "Q11131-1","NP_001170837.1","alpha-(1,3)-fucosyltransferase 7 isoform b","389",""
17366d17289
< "P32921-1","NP_035840.3","tryptophan--tRNA ligase, cytoplasmic isoform 1","481",""
17368c17291,17294
< "Q8BUG5-1","NP_840062.2","calcyphosin-2 isoform 1","592",""
---
> "Q9QUK4-1","NP_001119654.1","baculoviral IAP repeat-containing protein 1b","1447",""
> "Q5UAK0-3","NP_001034170.1","mesoderm induction early response protein 1 isoform b","511",""
> "Q9D074-1","NP_001239366.1","E3 ubiquitin-protein ligase MGRN1 isoform 1","533",""
> "Q64338-3","NP_001020739.1","calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform b","631",""
17371,17373d17296
< "P48026-1","NP_033147.1","diamine acetyltransferase 1 isoform 1","171",""
< "Q8BTF8-1","NP_848746.1","RNA-binding Raly-like protein isoform a","293",""
< "Q8BI67-1","NP_848849.2","zinc finger protein 473 homolog isoform 1","892",""
17376,17377c17299
< "Q8R1G1-1","NP_780434.1","threonine aspartase 1 isoform a","420",""
< "Q9JLG4-1","NP_058623.2","polycystic kidney disease 2-like 2 protein","621",""
---
> "O09116-1","NP_001191356.1","small proline-rich protein 3","238",""
17381d17302
< "Q9DA69-1","NP_083877.1","intraflagellar transport protein 43 homolog isoform 2","195",""
17383c17304
< "Q9CQS9-1","NP_079751.1","HAUS augmin-like complex subunit 2 isoform a","234",""
---
> "Q62178-1","NP_001156961.1","semaphorin-4A precursor","760",""
17384a17306
> "Q8CDR2-1","NP_001153143.1","radial spoke head protein 6 homolog A isoform 2","453",""
17386d17307
< "Q7TPD0-1","NP_849207.2","integrator complex subunit 3","1041",""
17388d17308
< "Q7TSI0-1","NP_808349.1","zinc finger protein 12 isoform 2","654",""
17397,17398d17316
< "B2RXS4-1","NP_620088.2","plexin-B2 precursor","1842",""
< "Q8CC21-1","NP_083980.2","tetratricopeptide repeat protein 19, mitochondrial isoform 2","352",""
17403a17322
> "Q6PCM1-1","NP_001033784.2","lysine-specific demethylase 3A isoform a","1323",""
17404a17324,17325
> "Q8BZH0-1","NP_001277694.1","zinc transporter ZIP13 isoform a precursor","374",""
> "Q80UK7-1","NP_001276497.1","spindle assembly abnormal protein 6 homolog isoform 3","560",""
17408c17329
< "P51163-1","NP_033505.1","uroporphyrinogen-III synthase isoform 1","265","The protein encoded by this gene is the fourth enzyme in the heme biosynthesis pathway. It converts hydroxymethylbilane to uroporphyrinogen III, a cyclic tetrapyrrole. This enzyme is defective in the autosomal recessive disorder congenital erythropoietic porphyria. Alternate promoter usage controls cell type-specific expression, including erythroid cell-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]. "
---
> "Q80TY4-1","NP_001231621.1","suppression of tumorigenicity 18 protein","1045",""
17410a17332
> "P56477-1","NP_001239311.1","interferon regulatory factor 5 isoform 1","506",""
17412d17333
< "Q9DAS1-1","NP_083571.1","chemokine-like factor isoform 1","152",""
17414d17334
< "Q8BZH0-1","NP_080997.1","zinc transporter ZIP13 isoform b precursor","361",""
17418a17339
> "Q9CQS9-1","NP_001277736.1","HAUS augmin-like complex subunit 2 isoform b","202",""
17421c17342,17343
< "Q9D7B1-1","NP_079794.1","tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 1","493",""
---
> "Q9DAS1-1","NP_001032930.1","chemokine-like factor isoform 4","96",""
> "Q80U23-1","NP_001278005.1","syntaphilin isoform b","495",""
17423,17425d17344
< "O09126-1","NP_038688.2","semaphorin-4D precursor","861",""
< "Q9Z1N5-1","NP_062667.1","spliceosome RNA helicase Ddx39b","428",""
< "Q8BY35-1","NP_038738.2","FYVE, RhoGEF and PH domain-containing protein 2 isoform 2","655",""
17428d17346
< "Q91YJ5-1","NP_598528.2","translation initiation factor IF-2, mitochondrial isoform 1 precursor","727",""
17430,17431c17348,17349
< "Q69Z61-1","NP_081833.1","PWWP domain-containing protein 2A isoform b","730",""
< "Q8BWW4-1","NP_001271452.1","la-related protein 4 isoform 5","720",""
---
> "Q8CI75-1","NP_001165628.1","DIS3-like exonuclease 2 isoform 1","884",""
> "Q8BXR9-1","NP_001277662.1","oxysterol-binding protein-related protein 6 isoform b","959",""
17433c17351
< "O35317-1","NP_058048.1","pre-B-cell leukemia transcription factor 3 isoform PBX3a","434",""
---
> "Q64691-1","NP_001171270.1","calpain-3 isoform c","729",""
17435a17354,17355
> "Q9Z0P7-1","NP_001020562.1","suppressor of fused homolog isoform 2","484",""
> "O88712-1","NP_001185788.1","C-terminal-binding protein 1 isoform 1","440",""
17441c17361
< "Q99M96-1","NP_071727.2","suppressor of tumorigenicity 7 protein isoform 1","534",""
---
> "Q6ZPS6-1","NP_001003909.2","ankyrin repeat and IBR domain-containing protein 1 isoform 2","1085",""
17443,17444c17363,17364
< "P68181-1","NP_035230.1","cAMP-dependent protein kinase catalytic subunit beta isoform 1","351",""
< "Q6NWV3-1","NP_112454.2","intraflagellar transport protein 122 homolog isoform 1","1183",""
---
> "Q3UME2-1","NP_001276595.1","transmembrane protein 241 isoform 1","297",""
> "Q6NSV7-1","NP_001019683.1","protein FAM149B1 isoform 1","578",""
17447c17367
< "P84228-1","NP_835734.2","histone H3.2","136","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. [provided by RefSeq, Aug 2015]. "
---
> "Q9JIY2-1","NP_001240776.1","E3 ubiquitin-protein ligase Hakai isoform 1","491",""
17450c17370,17371
< "P0C605-1","NP_035290.1","cGMP-dependent protein kinase 1 isoform beta","686",""
---
> "Q8BMQ2-1","NP_001159505.1","general transcription factor 3C polypeptide 4 isoform 2","676",""
> "Q9CYR6-1","NP_001157218.1","phosphoacetylglucosamine mutase isoform 2","501",""
17452,17453d17372
< "Q7TN99-1","NP_938042.2","cytoplasmic polyadenylation element-binding protein 3 isoform a","716",""
< "Q9CWR8-1","NP_062321.1","DNA (cytosine-5)-methyltransferase 3-like isoform 1","421","CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein that is a catalytically inactive regulatory factor of DNA methyltransferases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
17455d17373
< "Q8C569-1","NP_919233.1","protein FAM118B isoform 1","351",""
17457c17375
< "P63056-1","NP_703188.1","noelin-3 isoform A precursor","458",""
---
> "Q8C5N3-1","NP_001277669.1","pre-mRNA-splicing factor CWC22 homolog isoform 3","903",""
17459a17378
> "Q8BHD8-1","NP_001278140.1","protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform b","276",""
17460a17380,17381
> "Q61595-1","NP_001280564.1","kinectin isoform 2","1270",""
> "Q923T9-1","NP_001034227.1","calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 2","518",""
17461a17383
> "P09925-1","NP_001258653.2","surfeit locus protein 1 isoform 2","294",""
17463,17464c17385
< "Q8VIJ8-1","NP_853547.1","GATOR complex protein NPRL3 isoform 2","569",""
< "P11983-1","NP_038714.2","T-complex protein 1 subunit alpha isoform 1","556",""
---
> "P68181-1","NP_001157670.1","cAMP-dependent protein kinase catalytic subunit beta isoform 2","338",""
17467d17387
< "Q9Z0Z4-1","NP_851790.1","hephaestin isoform 2 precursor","847",""
17469c17389
< "Q01965-1","NP_032560.2","T-lymphocyte surface antigen Ly-9 isoform 1 precursor","654",""
---
> "Q8VIJ8-1","NP_001271288.1","GATOR complex protein NPRL3 isoform 1","582",""
17471d17390
< "Q8BRU4-1","NP_766320.2","C-type lectin domain family 9 member A isoform 2","238",""
17472a17392
> "Q7TSI0-1","NP_001276518.1","zinc finger protein 12 isoform 1","686",""
17474d17393
< "Q9CZT4-1","NP_079574.2","DNA-directed RNA polymerase III subunit RPC5 isoform 1","710",""
17476d17394
< "Q6S5J6-1","NP_109600.2","krev interaction trapped protein 1 isoform 1","736",""
17478a17397
> "Q9ES63-1","NP_001277923.1","ubiquitin carboxyl-terminal hydrolase 29","869",""
17480c17399,17400
< "Q9CW79-1","NP_084069.1","golgin subfamily A member 1 isoform a","758",""
---
> "Q64362-1","NP_001289195.1","AKT-interacting protein isoform 1","292",""
> "Q9D7B1-1","NP_001288105.1","tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 2","380",""
17482,17483c17402,17403
< "Q6ZPS6-1","NP_001276458.1","ankyrin repeat and IBR domain-containing protein 1 isoform 4","600",""
< "Q9CXC3-1","NP_083260.1","mitochondrial genome maintenance exonuclease 1","338",""
---
> "Q08351-1","NP_001116421.1","thrombopoietin receptor isoform 1 precursor","633",""
> "Q9JLG4-1","NP_001156476.1","polycystic kidney disease 2-like 2 protein","621",""
17485c17405
< "Q6ZWS4-1","NP_082684.1","protein cornichon homolog 3 isoform 1","179",""
---
> "Q91ZQ1-1","NP_001164430.1","cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform 2","836",""
17487d17406
< "Q5DTU0-1","NP_666214.1","actin filament-associated protein 1-like 2 isoform 3","769",""
17491a17411
> "Q8C166-1","NP_733467.1","copine-1","536","This gene encodes a protein that contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Its activity is also upregulated in mouse embryos. This gene and the gene for RNA binding motif protein 12 overlap at map location 2 H2. Two alternatively spliced variants that encode the same isoform have been identified for this gene. [provided by RefSeq, Jul 2008]. "
17494,17495c17414
< "Q60665-1","NP_035516.2","ski-like protein isoform a","675","This gene encodes a member of a small family of proteins that play a key role in the response of cells to extracellular growth signals. The encoded protein regulates members of the transforming growth factor beta signaling pathway. It is highly expressed in certain cancer cells, where it may have both tumor-suppressing and tumor-promoting roles. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]. "
< "Q8CCN5-1","NP_619622.3","breast carcinoma-amplified sequence 3 homolog isoform a","928",""
---
> "Q8BGW2-1","NP_001171283.1","WW domain binding protein 1-like isoform 1 precursor","385",""
17496a17416,17417
> "Q91VN4-1","NP_001161208.1","MICOS complex subunit Mic25 isoform 2","245",""
> "O35317-1","NP_001277505.1","pre-B-cell leukemia transcription factor 3 isoform PBX3b","351",""
17500d17420
< "Q6PFD9-1","NP_075355.1","nuclear pore complex protein Nup98-Nup96 isoform 2","1187",""
17501a17422
> "Q99JR5-1","NP_001161805.1","tubulointerstitial nephritis antigen-like precursor","466",""
17506,17508c17427,17429
< "Q8VE22-1","NP_077136.2","28S ribosomal protein S23, mitochondrial isoform a","177",""
< "Q6NZA9-1","NP_001161460.1","transcription initiation factor TFIID subunit 9B isoform 1","293",""
< "Q6ZPR4-1","NP_780671.2","potassium channel subfamily T member 1 isoform 1","1238","This gene encodes a member of the Slo potassium channel family that has shown to be activated by both sodium and chloride ions. This channel represents the largest potassium channel subunit yet identified. This channel may be important in development and pain signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
---
> "Q99M96-1","NP_001076784.1","suppressor of tumorigenicity 7 protein isoform 2","511",""
> "Q8C7U7-1","NP_001155239.1","polypeptide N-acetylgalactosaminyltransferase 6","622",""
> "Q8VCY8-1","NP_001277228.1","phospholipid phosphatase-related protein type 2 isoform 2","452",""
17510c17431
< "P10598-1","NP_034102.1","beta-casein isoform a precursor","231",""
---
> "Q9QUK0-1","NP_001263244.1","cyclin-dependent kinase-like 2 isoform 2","564",""
17513d17433
< "Q9CQH0-1","NP_080294.1","PDZK1-interacting protein 1 isoform 2 precursor","114",""
17517,17518d17436
< "Q8VCX5-1","NP_659071.1","calcium uptake protein 1, mitochondrial isoform 3","477",""
< "Q9EPK2-1","NP_598430.1","protein XRP2 isoform a","347",""
17520c17438
< "Q5RJG7-1","NP_848744.2","D-ribitol-5-phosphate cytidylyltransferase isoform 1","447",""
---
> "Q62507-1","NP_001185764.1","cochlin precursor","552",""
17522c17440
< "P59438-1","NP_001161336.1","Hermansky-Pudlak syndrome 5 protein homolog isoform 2","1093",""
---
> "Q9D5T7-1","NP_001276461.1","HORMA domain-containing protein 1 isoform a","392",""
17524c17442,17445
< "Q6PAM1-1","NP_001186624.1","alpha-taxilin","554",""
---
> "P84228-1","NP_038576.1","histone H3.2","136","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]. "
> "Q80VY2-1","NP_001156828.1","PAK4-inhibitor INKA2 isoform 2","281",""
> "Q9EQG9-1","NP_001157694.1","ceramide transfer protein isoform 2","598",""
> "Q8BTZ4-1","NP_001035956.1","anaphase-promoting complex subunit 5 isoform b","727",""
17525a17447
> "P05531-1","NP_001278676.1","X-linked lymphocyte-regulated protein PM1 isoform a","208",""
17527,17528d17448
< "Q924H7-1","NP_694725.3","WW domain-containing adapter protein with coiled-coil isoform 1","646",""
< "Q78YZ6-1","NP_062682.1","short coiled-coil protein isoform b","82",""
17530c17450,17454
< "Q99L00-1","NP_083897.2","HAUS augmin-like complex subunit 8 isoform 2","372",""
---
> "Q8R3P6-1","NP_001071099.1","integrator complex subunit 14","515",""
> "Q80W99-1","NP_001239416.1","cation channel sperm-associated protein 3 isoform 1","395",""
> "P28231-1","NP_001153484.1","gap junction beta-3 protein","270",""
> "Q99J78-1","NP_001240712.1","differentially expressed in FDCP 8 isoform 1","472",""
> "Q6NZA9-1","NP_001001176.2","transcription initiation factor TFIID subunit 9B isoform 2","249",""
17532c17456
< "Q9WTU6-1","NP_997575.2","mitogen-activated protein kinase 9 isoform alpha2","423",""
---
> "Q8K3D3-1","NP_001277481.1","DNA repair protein SWI5 homolog isoform a","121",""
17534c17458
< "P54830-1","NP_038671.2","tyrosine-protein phosphatase non-receptor type 5","541",""
---
> "Q5SPW0-1","NP_001277557.1","vacuolar protein sorting-associated protein 54 isoform 2","965",""
17536c17460
< "P52480-1","NP_035229.2","pyruvate kinase PKM isoform M2","531",""
---
> "Q9Z307-1","NP_001239136.1","inward rectifier potassium channel 16","419",""
17537a17462
> "O54792-1","NP_001288734.1","transcription factor HES-2","157","The protein encoded by this gene belongs to the mammalian Hes gene family, the mammalian homologues of Drosophila hairy and Enhancer of split. Hes 2 is a basic helix-loop-helix transcriptional repressor and is an effector of the Notch signaling pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. "
17538a17464
> "Q9JIA7-1","NP_001166032.1","sphingosine kinase 2","617","This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. The gene product also enhances apoptosis in different cell types and suppresses cellular proliferation. In mast cells, the encoded protein is necessary for influx of calcium, protein kinase C activation, and cytokine production and degranulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]. "
17541,17545c17467,17470
< "Q91VM9-1","NP_666253.1","inorganic pyrophosphatase 2, mitochondrial isoform 1 precursor","330",""
< "P52792-1","NP_034422.2","hexokinase-4 isoform 1","465",""
< "Q9CYR6-1","NP_082628.3","phosphoacetylglucosamine mutase isoform 1","542",""
< "Q8CIV3-1","NP_700453.1","lipase member H isoform 2 precursor","421",""
< "Q8BHD8-1","NP_705822.1","protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform a","359",""
---
> "O35551-1","NP_001278070.1","rab GTPase-binding effector protein 1 isoform 2","819",""
> "Q8BHI4-1","NP_001158046.1","kelch repeat and BTB domain-containing protein 3","607",""
> "Q8BUR3-1","NP_001277625.1","forkhead box protein J3 isoform 2","589",""
> "Q6NZF1-1","NP_001263696.1","zinc finger CCCH domain-containing protein 11A","792",""
17549c17474
< "P47759-1","NP_032767.1","neuronal vesicle trafficking-associated protein 2 isoform 1","171",""
---
> "D3KU66-1","NP_001186141.1","acetylserotonin O-methyltransferase isoform 1","387","This gene belongs to the methyltransferase superfamily and is located in the pseudoautosomal region (PAR) of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin and is abundant in the pineal gland. Two amino acid substitutions (R78G and R242C) are present in the encoded protein derived from the reference strain, C57BL/6J, and this protein shows low enzyme activity relative to the protein derived from other strains. [provided by RefSeq, May 2015]. "
17553d17477
< "Q9D5T7-1","NP_080765.1","HORMA domain-containing protein 1 isoform b","374",""
17555c17479
< "Q9D0U6-1","NP_081135.3","repressor of RNA polymerase III transcription MAF1 homolog","258",""
---
> "Q8BVK9-1","NP_084470.1","sp110 nuclear body protein","445",""
17556a17481,17484
> "Q8VCX5-1","NP_001278371.1","calcium uptake protein 1, mitochondrial isoform 1","483",""
> "P97357-1","NP_001264886.1","TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 2","440",""
> "P11983-1","NP_001277641.1","T-complex protein 1 subunit alpha isoform 2","507",""
> "Q9DCW2-1","NP_001182013.1","phospholipid scramblase 2","307",""
17559a17488
> "Q9D8Z1-1","NP_001186116.1","activating signal cointegrator 1 complex subunit 1","356",""
17561d17489
< "A1Z198-1","NP_001155886.1","NLR family, pyrin domain containing 1B isoform 3","1177",""
17562a17491
> "Q99L00-1","NP_001156514.1","HAUS augmin-like complex subunit 8 isoform 1","373",""
17565,17566d17493
< "Q01147-1","NP_598589.2","cyclic AMP-responsive element-binding protein 1 isoform A","327",""
< "Q8VBV9-1","NP_570936.1","olfactory receptor 51E2","320","Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. "
17569a17497
> "P60766-2","NP_001230698.1","cell division control protein 42 homolog isoform 2","191",""
17575d17502
< "Q8BGW2-1","NP_666211.3","WW domain binding protein 1-like isoform 2 precursor","369",""
17576a17504
> "P97447-1","NP_001070830.1","four and a half LIM domains protein 1 isoform 2","296",""
17579,17581c17507
< "Q8BTZ4-1","NP_067480.2","anaphase-promoting complex subunit 5 isoform a","740",""
< "O35551-1","NP_062273.2","rab GTPase-binding effector protein 1 isoform 1","862",""
< "Q9QUK0-1","NP_796244.2","cyclin-dependent kinase-like 2 isoform 2","564",""
---
> "O08688-1","NP_001288179.1","calpain-5","640","The protein encoded by this gene is a member of the calpain family of proteins. Unlike many members of the calpain gene family, this gene lacks a calmodulin-like domain, required for calcium binding. Mouse models for Huntington's disease displayed increased levels of the protein encoded by this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. "
17583d17508
< "Q3TY86-1","NP_780387.2","apoptosis-inducing factor 3 isoform 2","598",""
17587,17588d17511
< "Q9D8Z1-1","NP_081213.1","activating signal cointegrator 1 complex subunit 1","356",""
< "Q9CX84-1","NP_080722.1","regulator of G-protein signaling 19 isoform b","216",""
17590,17591c17513
< "Q9QZB0-1","NP_064342.1","regulator of G-protein signaling 17 isoform 2","210",""
< "Q99PQ2-1","NP_444398.1","E3 ubiquitin-protein ligase TRIM11 isoform 2","467",""
---
> "Q99PN3-1","NP_001020770.2","tripartite motif-containing protein 26","545",""
17595a17518
> "P41242-1","NP_001272783.1","megakaryocyte-associated tyrosine-protein kinase isoform 3","465",""
17597c17520
< "O35149-1","NP_035904.2","zinc transporter 4 isoform a","430",""
---
> "Q80UW0-1","NP_001070670.1","heparan-sulfate 6-O-sulfotransferase 2 isoform 1","652",""
17599d17521
< "Q8CDR2-1","NP_112545.2","radial spoke head protein 6 homolog A isoform 1","708",""
17600a17523,17524
> "Q5G866-1","NP_001012307.1","alpha-defensin 23 precursor","93",""
> "Q9JHE4-1","NP_001171162.1","galactosylceramide sulfotransferase","423",""
17605a17530
> "Q6S5J6-1","NP_001164023.1","krev interaction trapped protein 1 isoform 2","697",""
17608d17532
< "Q9JIT1-1","NP_067445.3","RING finger protein 32","368",""
17611a17536
> "Q925Q3-1","NP_001171065.1","mitochondrial sodium/calcium exchanger protein isoform 2 precursor","568",""
17615d17539
< "O70281-1","NP_038865.1","protein-tyrosine sulfotransferase 1","370",""
17620d17543
< "Q8CBR6-1","NP_001162013.1","tsukushin precursor","354",""
17622,17624c17545,17546
< "Q99ME3-1","NP_001186082.1","synphilin-1 isoform 1","965",""
< "Q62315-1","NP_068678.1","protein Jumonji isoform 1","1234",""
< "Q61140-1","NP_034084.2","breast cancer anti-estrogen resistance protein 1 isoform B","874",""
---
> "Q9QYE6-1","NP_001185933.1","golgin subfamily A member 5","729",""
> "Q9EP75-1","NP_001191262.1","leukotriene-B4 omega-hydroxylase 3","524",""
17627a17550,17551
> "Q9D162-1","NP_001157213.1","coiled-coil domain-containing protein 167 isoform 1","104",""
> "Q99ME3-1","NP_001186080.1","synphilin-1 isoform 1","965",""
17628a17553
> "O35719-1","NP_001239491.1","DNA repair protein RAD51 homolog 2 isoform 2","258",""
17629a17555
> "Q8R1G1-1","NP_001153112.1","threonine aspartase 1 isoform a","420",""
17631d17556
< "P50615-1","NP_033900.1","protein BTG3","252","This gene encodes B cell translocation gene 3, a member of the BTG gene family. This family is defined by a conserved N-terminal domain, known to bind transcription factors, and a less conserved C-terminal domain. This protein is thought to have anti-proliferative properties, and may be involved in regulating the G1-S transition to suppress cell cycle progression. Mice deficient for this gene display an increased incidence of lung cancers, and many human lung cancer cells exhibit decreased levels of B cell translocation gene 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 17. [provided by RefSeq, Jul 2014]. "
17635,17637c17560
< "P97447-1","NP_034341.2","four and a half LIM domains protein 1 isoform 3","280",""
< "Q923T9-1","NP_848712.2","calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 1","529",""
< "P20029-1","NP_071705.3","endoplasmic reticulum chaperone BiP precursor","655",""
---
> "Q6ZWS4-1","NP_001153683.1","protein cornichon homolog 3 isoform 2","160",""
17639c17562
< "B2RPV6-1","NP_081889.1","multimerin-1 isoform a precursor","1210",""
---
> "Q7TPD0-1","NP_663515.2","integrator complex subunit 3","1041",""
17644,17646c17567,17568
< "Q9CR89-1","NP_080444.1","endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform 1","377",""
< "Q8BH75-1","NP_080535.2","E3 ubiquitin-protein ligase NRDP1","317",""
< "P25085-1","NP_112444.1","interleukin-1 receptor antagonist protein isoform 1","159",""
---
> "Q61087-1","NP_001264857.1","laminin subunit beta-3 precursor","1168",""
> "Q8K387-1","NP_001277354.1","ubiquitin carboxyl-terminal hydrolase 45 isoform 2","765",""
17650a17573,17574
> "Q924H7-1","NP_001139770.1","WW domain-containing adapter protein with coiled-coil isoform 2","543",""
> "P52792-1","NP_001274315.1","hexokinase-4 isoform 2","465",""
17651a17576
> "Q8VC19-1","NP_001278764.1","5-aminolevulinate synthase, nonspecific, mitochondrial precursor","642",""
17654d17578
< "Q3UME2-1","NP_848916.2","transmembrane protein 241 isoform 2","282",""
17656,17657c17580
< "Q5RKR3-1","NP_796167.2","immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform b precursor","745",""
< "P35279-1","NP_077249.1","ras-related protein Rab-6A isoform 2","208",""
---
> "Q6PAM1-1","NP_001005506.2","alpha-taxilin","554",""
17660c17583,17585
< "O54879-1","NP_032279.1","high mobility group protein B3","200",""
---
> "Q8CBE3-1","NP_001034477.1","WD repeat-containing protein 37 isoform a","496",""
> "Q3TY86-1","NP_001277999.1","apoptosis-inducing factor 3 isoform 1","605",""
> "P58269-1","NP_001254554.1","zinc finger protein DPF3 isoform 1","378",""
17662,17663c17587
< "Q9JIA7-1","NP_975009.1","sphingosine kinase 2","617","This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. The gene product also enhances apoptosis in different cell types and suppresses cellular proliferation. In mast cells, the encoded protein is necessary for influx of calcium, protein kinase C activation, and cytokine production and degranulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]. "
< "Q9CQV7-1","NP_080608.3","mitochondrial import inner membrane translocase subunit TIM14 isoform 1","116",""
---
> "P35279-1","NP_001157135.1","ras-related protein Rab-6A isoform 1","208",""
17665,17666c17589,17590
< "Q62507-1","NP_031754.1","cochlin precursor","552",""
< "O35174-1","NP_851834.1","potassium voltage-gated channel subfamily S member 2","477",""
---
> "A2A935-1","NP_001277955.1","histone-lysine N-methyltransferase PRDM16 isoform 3","1274",""
> "A1Z198-1","NP_001035786.1","NLR family, pyrin domain containing 1B isoform 1","1174",""
17667a17592,17593
> "P18911-1","NP_001036192.1","retinoic acid receptor gamma isoform 2","447",""
> "Q9CX84-1","NP_001278135.1","regulator of G-protein signaling 19 isoform b","216",""
17673a17600
> "Q9QZB0-1","NP_001155294.1","regulator of G-protein signaling 17 isoform 1","230",""
17678d17604
< "Q8BTY8-1","NP_848787.2","sec1 family domain-containing protein 2 isoform b","477",""
17679a17606
> "P51163-1","NP_001289014.1","uroporphyrinogen-III synthase isoform 1","265","The protein encoded by this gene is the fourth enzyme in the heme biosynthesis pathway. It converts hydroxymethylbilane to uroporphyrinogen III, a cyclic tetrapyrrole. This enzyme is defective in the autosomal recessive disorder congenital erythropoietic porphyria. Alternate promoter usage controls cell type-specific expression, including erythroid cell-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]. "
17685,17686d17611
< "Q7TMY4-1","NP_079711.1","THO complex subunit 7 homolog isoform 1","204",""
< "Q8CG46-1","NP_722503.1","structural maintenance of chromosomes protein 5 isoform 2","1087",""
17689d17613
< "Q8C5N3-1","NP_766255.1","pre-mRNA-splicing factor CWC22 homolog isoform 2","902",""
17691c17615
< "P18911-1","NP_035374.3","retinoic acid receptor gamma isoform 1","458",""
---
> "O55042-1","NP_001035916.1","alpha-synuclein","140",""
17695c17619,17620
< "Q8C0C4-1","NP_899133.2","serine-rich coiled-coil domain-containing protein 1","895",""
---
> "Q91VM9-1","NP_001280570.1","inorganic pyrophosphatase 2, mitochondrial isoform 2 precursor","329",""
> "Q9Z1N5-1","NP_001239386.1","spliceosome RNA helicase Ddx39b","428",""
17697c17622
< "Q9QZB1-1","NP_067349.2","regulator of G-protein signaling 20 isoform 2","239",""
---
> "Q9CSP9-1","NP_001277429.1","tetratricopeptide repeat protein 14 isoform c","714",""
17698a17624,17625
> "Q9CYG7-1","NP_001278084.1","mitochondrial import receptor subunit TOM34 isoform a","309",""
> "Q9CQH0-1","NP_001158029.1","PDZK1-interacting protein 1 isoform 1","181",""
17701c17628
< "P97357-1","NP_067441.1","TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 1","453",""
---
> "P61969-1","NP_001155241.1","LIM domain transcription factor LMO4","165",""
17703,17704c17630
< "P70423-1","NP_031541.1","cationic amino acid transporter 3","618","The protein encoded by this gene is a member of the system y+ cationic amino acid transporter family. Proteins of this family allow uptake of arginine from extracellular media. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. "
< "Q62178-1","NP_038686.3","semaphorin-4A precursor","760",""
---
> "O09012-1","NP_001264259.1","peroxisomal targeting signal 1 receptor isoform 2","602",""
17706d17631
< "P39053-1","NP_034195.2","dynamin-1 isoform 1","864","This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein is a GTPase which is required for membrane recycling, including vesicle endocytosis in neurons. It may also be involved in cellular fission via association with microtubules and actin filaments. Mutations in this gene have been shown to cause seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. "
17708c17633
< "P09925-1","NP_038705.2","surfeit locus protein 1 isoform 1","306",""
---
> "Q8BG09-1","NP_001240746.1","transmembrane protein 184B isoform 1","407",""
17712a17638
> "Q9QYY8-1","NP_001156342.1","spastin isoform 1","614",""
17714c17640,17641
< "Q91VN4-1","NP_079627.3","MICOS complex subunit Mic25 isoform 1","273",""
---
> "Q9DAM5-1","NP_001239313.1","mitochondrial thiamine pyrophosphate carrier isoform 1","318",""
> "P41778-1","NP_001278437.1","pre-B-cell leukemia transcription factor 1 isoform b","347","This gene encodes a homeobox protein that belongs to the three-amino-acid loop extension/Pre-B cell leukemia transcription factor (TALE/PBX) family of proteins. The encoded protein is involved in several biological processes during embryogenesis including steroidogenesis, sexual development and the maintenance of hematopoietic stem cells. This protein functions in the development of several organ systems and plays a role in skeletal patterning and programming. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]. "
17715a17643,17644
> "Q8VCD7-1","NP_001165566.1","lysine-specific demethylase 4C isoform 2","1071",""
> "P25085-1","NP_001034790.1","interleukin-1 receptor antagonist protein isoform 2 precursor","178",""
17718d17646
< "Q9Z0P7-1","NP_056567.2","suppressor of fused homolog isoform 1","485",""
17720d17647
< "Q8K3P5-1","NP_997649.1","CCR4-NOT transcription complex subunit 6 isoform 2","552",""
17724d17650
< "Q9ES63-1","NP_067298.2","ubiquitin carboxyl-terminal hydrolase 29","869",""
17725a17652
> "P70423-1","NP_001288769.1","cationic amino acid transporter 3","618","The protein encoded by this gene is a member of the system y+ cationic amino acid transporter family. Proteins of this family allow uptake of arginine from extracellular media. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. "
17727c17654
< "Q60715-1","NP_035160.1","prolyl 4-hydroxylase subunit alpha-1 isoform 3 precursor","534",""
---
> "Q5U4D8-1","NP_001171092.1","sodium-dependent multivitamin transporter","634",""
17734d17660
< "A2AR50-1","NP_780420.1","ras-specific guanine nucleotide-releasing factor RalGPS1 isoform a","585",""
17736c17662,17663
< "P61969-1","NP_034853.1","LIM domain transcription factor LMO4","165",""
---
> "Q9QXN0-1","NP_001071063.1","protein Shroom3 isoform 2","1805",""
> "P46662-1","NP_001239179.1","merlin isoform 1","591",""
17737a17665
> "Q8C9X6-1","NP_001263279.1","enhancer of polycomb homolog 1 isoform 3","61",""
17740d17667
< "P70453-1","NP_032828.2","high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform 1 precursor","456",""
17746,17747c17673
< "Q6NV72-1","NP_775592.2","WD repeat and coiled-coil-containing protein isoform 2","635",""
< "Q501J7-1","NP_780515.2","phosphatase and actin regulator 4 isoform 1","694",""
---
> "B2RPV6-1","NP_001156979.1","multimerin-1 isoform b precursor","1209",""
17749a17676
> "Q9D772-1","NP_001153055.1","protein FAM219A isoform 1","168",""
17756c17683
< "Q9D4V4-1","NP_083524.2","TATA box-binding protein-associated factor RNA polymerase I subunit D isoform 2","322",""
---
> "Q9QZ05-1","NP_001171277.1","eIF-2-alpha kinase GCN2 isoform 2","1536",""
17759c17686
< "Q6PCM1-1","NP_766589.1","lysine-specific demethylase 3A isoform a","1323",""
---
> "Q9WTP6-1","NP_001029138.1","adenylate kinase 2, mitochondrial isoform a","239",""
17762c17689
< "Q9CYG7-1","NP_080272.1","mitochondrial import receptor subunit TOM34 isoform b","309",""
---
> "Q61140-1","NP_001185768.1","breast cancer anti-estrogen resistance protein 1 isoform A","874",""
17767d17693
< "Q8K3D3-1","NP_780399.1","DNA repair protein SWI5 homolog isoform b","89",""
17770c17696,17697
< "Q9CR83-1","NP_080710.1","probable RNA-binding protein 18 isoform 1","190",""
---
> "Q9EQS9-1","NP_001277244.1","immunoglobulin superfamily DCC subclass member 4 isoform 1 precursor","1253",""
> "Q62315-1","NP_001191972.1","protein Jumonji isoform 1","1234",""
17781,17782c17708
< "Q8BHR2-1","NP_766401.1","ecto-NOX disulfide-thiol exchanger 1 isoform 2","643",""
< "Q99M80-1","NP_067439.1","receptor-type tyrosine-protein phosphatase T isoform d precursor","1435",""
---
> "Q99M80-1","NP_001278078.1","receptor-type tyrosine-protein phosphatase T isoform a precursor","1455",""
17783a17710
> "Q01147-1","NP_034082.1","cyclic AMP-responsive element-binding protein 1 isoform B","341",""
17784a17712,17713
> "Q07563-1","NP_001277754.1","collagen alpha-1(XVII) chain isoform 1","1470",""
> "A3KGF7-1","NP_001277719.1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform b","1158",""
17786,17787c17715,17717
< "Q64691-1","NP_031627.2","calpain-3 isoform a","821",""
< "Q6NSV7-1","NP_759011.2","protein FAM149B1 isoform 2","485",""
---
> "P47759-1","NP_001277609.1","neuronal vesicle trafficking-associated protein 2 isoform 1","171",""
> "P33534-1","NP_001191300.1","kappa-type opioid receptor isoform 1","380","This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]. "
> "Q9DCK3-1","NP_001239517.1","tetraspanin-4","238",""
17790,17791d17719
< "P05531-1","NP_035855.1","X-linked lymphocyte-regulated protein PM1 isoform a","208",""
< "P60766-2","NP_033991.1","cell division control protein 42 homolog isoform 1 precursor","191",""
17793d17720
< "Q9Z2B2-1","NP_035528.1","brain mitochondrial carrier protein 1 isoform 2 precursor","322",""
17795d17721
< "Q8BXR9-1","NP_663500.2","oxysterol-binding protein-related protein 6 isoform a","967",""
17796a17723
> "Q9QZB1-1","NP_001277301.1","regulator of G-protein signaling 20 isoform 3","208",""
17799a17727
> "P39053-1","NP_001288666.1","dynamin-1 isoform 2","851","This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein is a GTPase which is required for membrane recycling, including vesicle endocytosis in neurons. It may also be involved in cellular fission via association with microtubules and actin filaments. Mutations in this gene have been shown to cause seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. "
17803,17806d17730
< "Q8CBQ5-1","NP_083020.2","phosphatidylinositol 4-kinase type 2-beta isoform 2","446",""
< "Q8C7U7-1","NP_766039.2","polypeptide N-acetylgalactosaminyltransferase 6","622",""
< "Q7TPS5-1","NP_084173.1","C2 domain-containing protein 5 isoform 2","999",""
< "P56477-1","NP_036187.1","interferon regulatory factor 5 isoform 2","497",""
17810d17733
< "Q9CYC3-1","NP_080683.2","transmembrane protein 39A isoform 1","486",""
17812a17736
> "Q60775-1","NP_001273340.1","ETS-related transcription factor Elf-1 isoform 1","612",""
17816,17818d17739
< "Q9D1N4-1","NP_079652.1","protein myomaker isoform 1","221",""
< "Q8CEC0-1","NP_765982.2","nuclear pore complex protein Nup88 isoform 1","742",""
< "Q80U30-1","NP_808230.2","protein CLEC16A isoform 1","1036",""
17819a17741,17742
> "P32921-1","NP_001157786.1","tryptophan--tRNA ligase, cytoplasmic isoform 2","475",""
> "Q9WTU6-1","NP_001157143.1","mitogen-activated protein kinase 9 isoform beta2","423",""
17823a17747
> "O54879-1","NP_001280552.1","high mobility group protein B3","200",""
17826d17749
< "Q60929-1","NP_001278125.1","myocyte-specific enhancer factor 2A isoform d","351",""
17828c17751
< "Q8R0A7-1","NP_758490.3","uncharacterized protein KIAA0513 isoform a","407",""
---
> "Q8BH75-1","NP_001157709.1","E3 ubiquitin-protein ligase NRDP1","317",""
17830d17752
< "Q99PR8-1","NP_077761.3","heat shock protein beta-2 isoform 1","182",""
17833c17755,17756
< "Q9CSP9-1","NP_081895.2","tetratricopeptide repeat protein 14 isoform a","766",""
---
> "Q9Z2Y2-1","NP_001240310.1","beta-1,4-galactosyltransferase 2","369",""
> "Q8VBV9-1","NP_001161975.1","olfactory receptor 51E2","320","Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. "
17834a17758
> "Q9ESD6-1","NP_001239408.1","CKLF-like MARVEL transmembrane domain-containing protein 7 isoform 2","134",""
17836c17760
< "Q8CBE3-1","NP_766033.1","WD repeat-containing protein 37 isoform a","496",""
---
> "P70453-1","NP_001116231.1","high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform 2","482",""
17838,17839d17761
< "Q8BHD7-1","NP_835458.1","polypyrimidine tract-binding protein 3 isoform 2","523",""
< "A2AB59-1","NP_598476.2","rho GTPase-activating protein 27 isoform 2","670",""
17843c17765,17766
< "Q5SPW0-1","NP_620692.3","vacuolar protein sorting-associated protein 54 isoform 1","977",""
---
> "Q8R0X2-1","NP_001165567.1","CDK2-associated and cullin domain-containing protein 1 isoform 2","347",""
> "Q9EQR6-1","NP_001156705.1","Fanconi anemia group G protein homolog isoform 2","616",""
17847d17769
< "Q99M28-1","NP_033096.2","RNA-binding protein with serine-rich domain 1 isoform 1","305",""
17848a17771
> "Q99M28-1","NP_001073596.1","RNA-binding protein with serine-rich domain 1 isoform 1","305",""
17855d17777
< "Q8K0L9-1","NP_851401.1","zinc finger and BTB domain-containing protein 20 isoform S","668",""
17858d17779
< "Q9Z1N9-1","NP_067443.2","protein unc-13 homolog B isoform 1","1602",""
17862a17784
> "P16330-1","NP_001139790.1","2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform 1","400",""
17864d17785
< "Q9CUN6-1","NP_083714.3","E3 ubiquitin-protein ligase SMURF1 isoform 2","728",""
17866,17867d17786
< "P10637-1","NP_034968.3","microtubule-associated protein tau isoform b","372",""
< "Q9D906-1","NP_083111.1","ubiquitin-like modifier-activating enzyme ATG7 isoform 2","698","This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. "
17869a17789,17791
> "P58462-1","NP_001184250.1","forkhead box protein P1 isoform 2","673",""
> "Q8C551-1","NP_001334384.1","RAD51-associated protein 1 isoform 2","336",""
> "Q8K2Q9-1","NP_001107784.1","shootin-1 isoform 1","631",""
17870a17793
> "Q7TS68-1","NP_001159413.1","putative methyltransferase NSUN6 isoform a","476",""
17872c17795,17796
< "P28705-1","NP_033133.1","retinoic acid receptor RXR-gamma isoform 1","463",""
---
> "P57722-1","NP_001334145.1","poly(rC)-binding protein 3 isoform 2","370",""
> "P32848-1","NP_001317615.1","parvalbumin alpha","110",""
17874c17798,17799
< "P22005-1","NP_001335138.1","proenkephalin-A precursor","268",""
---
> "Q8R2G4-5","NP_001297594.1","ecto-ADP-ribosyltransferase 3 isoform 3 precursor","350",""
> "Q80VW7-1","NP_001038979.1","microtubule organization protein AKNA","1404",""
17876a17802,17803
> "O35618-1","NP_001289730.1","protein Mdm4 isoform 1","490","This gene encodes a protein that has been shown to negatively regulate the activity of the tumor suppressor protein p53. Homozygous knockout mice exhibit embryonic lethality as a result of p53-dependent apoptosis and cell cycle arrest. Amplification of this gene or overexpression of the encoded protein has been linked to a range of human cancers. A pseudogene has been identified on the X chromosome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]. "
> "Q8CH25-1","NP_079966.2","SAFB-like transcription modulator isoform a","1031",""
17878c17805,17806
< "Q9D773-1","NP_079578.1","39S ribosomal protein L2, mitochondrial isoform 1 precursor","306",""
---
> "P37237-1","NP_001159834.1","fibroblast growth factor 8 isoform 3 precursor","215",""
> "Q9CUN6-1","NP_001033716.1","E3 ubiquitin-protein ligase SMURF1 isoform 1","731",""
17880,17881c17808,17809
< "Q99JB6-1","NP_473380.1","forkhead box protein P3","429","The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene result in the scurfy phenotype (sf). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. "
< "P55088-1","NP_033830.2","aquaporin-4 isoform M1","323","This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]. "
---
> "E9Q9A9-1","NP_001334377.1","2'-5'-oligoadenylate synthase 2 isoform 1","751",""
> "P20334-1","NP_001070977.1","tumor necrosis factor receptor superfamily member 9 isoform 1 precursor","256",""
17885c17813
< "P35951-1","NP_034830.2","low-density lipoprotein receptor isoform 1 precursor","862",""
---
> "P47774-1","NP_001288642.1","C-C chemokine receptor type 7 isoform b","315",""
17887c17815
< "Q5RJH6-1","NP_001153729.1","protein SMG7 isoform 1","1146",""
---
> "P35546-1","NP_001074249.1","proto-oncogene tyrosine-protein kinase receptor Ret isoform c precursor","1073",""
17888a17817
> "P49182-1","NP_001317976.1","heparin cofactor 2 precursor","478",""
17889a17819,17820
> "P10637-1","NP_001033698.1","microtubule-associated protein tau isoform a","430",""
> "Q8K2K6-4","NP_001297642.1","arf-GAP domain and FG repeat-containing protein 1 isoform 2","530",""
17891a17823
> "O08644-1","NP_001139823.1","ephrin type-B receptor 6 precursor","1014",""
17893c17825,17826
< "P58462-1","NP_444432.1","forkhead box protein P1 isoform 1","705",""
---
> "Q64521-1","NP_001139292.1","glycerol-3-phosphate dehydrogenase, mitochondrial precursor","727",""
> "O08807-1","NP_001300640.1","peroxiredoxin-4 isoform 1 precursor","275",""
17895d17827
< "O08644-1","NP_031706.3","ephrin type-B receptor 6 precursor","1014",""
17897d17828
< "Q9JLV9-1","NP_862900.1","prolactin-2C5 isoform 2 precursor","222",""
17898a17830
> "P97929-1","NP_001074470.1","breast cancer type 2 susceptibility protein homolog","3329",""
17901d17832
< "P70298-1","NP_031830.2","homeobox protein cut-like 2","1426","This gene is a member of the Cut family of transcription factors that have multiple DNA binding domains and regulate cell proliferation and differentiation. This gene is primarily expressed in nervous tissues where it controls the proliferation of neuronal precursors, and may play a role in organogenesis earlier during embryonic development. Mice lacking the encoded protein exhibit smaller spinal cords with deficits in neural progenitor development as well as in neuroblast and interneuron differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. "
17902a17834
> "Q8R331-1","NP_001297676.1","zinc finger HIT domain-containing protein 1 isoform 2","154",""
17904,17905c17836,17839
< "P46938-1","NP_033560.1","transcriptional coactivator YAP1 isoform 2","472","This gene encodes a protein which binds to the SH3 domain of the Yes proto-oncogene product, a tyrosine kinase. This protein contains a WW domain, consisting of four conserved aromatic amino acids including two tryptophan residues. This conserved WW domain is found in various structural, regulatory and signaling molecules in various species, and may play a role in protein-protein interaction. Following cellular damage, phosphorylation of this encoded protein may suppress apoptosis. This protein may be involved in malignant transformation in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]. "
< "P47774-1","NP_031745.2","C-C chemokine receptor type 7 isoform a precursor","378",""
---
> "Q3U1U7-1","NP_001304280.1","aryl hydrocarbon receptor repressor isoform 2","573","This gene encodes a protein that represses aryl hydrocarbon receptor-dependent signaling. The encoded protein competes with the aryl hydrocarbon receptor transcription factor for heterodimerization with the aryl hydrocarbon receptor nuclear translocator protein and binding to xenobiotic response element (XRE) sequence in many genes. This protein is implicated in the regulation of cell growth and differentiation as well as mediating dioxin toxicity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]. "
> "Q7TMB8-1","NP_001158133.1","cytoplasmic FMR1-interacting protein 1 isoform a","1253",""
> "Q8R5C8-1","NP_001186070.1","zinc finger MYND domain-containing protein 11 isoform gamma","602",""
> "P41183-1","NP_001334955.1","B-cell lymphoma 6 protein homolog","707",""
17907d17840
< "P28230-1","NP_032150.2","gap junction beta-1 protein","283","This gene is a member of the gap junction protein (connexin) family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of ions and small molecules between cells. Mutations in a similar gene in human cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Oct 2014]. "
17908a17842
> "Q3U7U3-1","NP_001334080.1","F-box only protein 7 isoform 3","442",""
17910d17843
< "Q3TY92-1","NP_149063.2","methyl-CpG-binding domain protein 6 isoform 1","1005",""
17916a17850
> "O88508-1","NP_001258682.1","DNA (cytosine-5)-methyltransferase 3A isoform 1","908","This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]. "
17918,17919c17852
< "Q8BLB7-1","NP_766375.1","lethal(3)malignant brain tumor-like protein 3 isoform 1","883",""
< "P35546-1","NP_033076.2","proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor","1115",""
---
> "O88632-1","NP_001298080.1","semaphorin-3F isoform 1 precursor","785",""
17921d17853
< "Q64521-1","NP_034404.3","glycerol-3-phosphate dehydrogenase, mitochondrial precursor","727",""
17930d17861
< "P53702-1","NP_032248.3","cytochrome c-type heme lyase","272",""
17932c17863
< "Q02853-1","NP_032632.1","stromelysin-3 preproprotein","492","This gene encodes a member of the matrix metalloproteinase family of endopeptidases that are involved in remodeling extracellular matrix during, for example, embryonic development and tumor progression. The encoded protein undergoes post-translational proteolytic processing by furin endopeptidase to form an active enzyme. Subcutaneous introduction of cells expressing the encoded protein into nude mice results in increased tumor incidence. Mice lacking the encoded protein exhibit a decreased incidence of chemically-induced tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
---
> "Q8R179-1","NP_001298045.1","kelch repeat and BTB domain-containing protein 4 isoform 1","534",""
17933a17865
> "Q3UHN9-1","NP_001335029.1","bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1","882",""
17934a17867
> "Q9QXX4-1","NP_001171043.1","calcium-binding mitochondrial carrier protein Aralar2 isoform 2","675",""
17935a17869
> "P36898-1","NP_001264145.1","bone morphogenetic protein receptor type-1B isoform a precursor","502","This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type I receptor, and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important in skeletal and bone development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. "
17937a17872
> "Q9CRC9-1","NP_001033104.1","glucosamine-6-phosphate isomerase 2 isoform 1","276",""
17942c17877
< "O89086-1","NP_001159883.1","RNA-binding protein 3 isoform 2","153",""
---
> "P08152-1","NP_001334387.1","E3 SUMO-protein ligase EGR2 isoform 2","420",""
17945c17880,17881
< "P42227-1","NP_998825.1","signal transducer and activator of transcription 3 isoform 2","769","The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]. "
---
> "Q02788-1","NP_001334136.1","collagen alpha-2(VI) chain isoform 2 precursor","933",""
> "Q8BMT4-1","NP_001334110.1","transforming growth factor beta activator LRRC33 isoform 2 precursor","693",""
17946a17883
> "Q9CS42-1","NP_001300687.1","ribose-phosphate pyrophosphokinase 2 isoform 1","321",""
17948c17885
< "Q9CPV5-1","NP_080204.1","polyamine-modulated factor 1 isoform 1","202",""
---
> "P13864-1","NP_001186360.2","DNA (cytosine-5)-methyltransferase 1 isoform 1","1620","This gene encodes a methyltransferase that preferentially methylates cytosines of CpG residues in hemimethylated DNA to generate fully methylated CpG base pairs during DNA replication. This enzyme plays roles in diverse cellular processes including cell cycle regulation, DNA repair, and telomere maintenance. The encoded protein is composed of an N-terminal domain with a nuclear localization sequence and replication fork-targeting domain, a DNA-binding CXXC domain, two bromo-adjacent homology domains, and a C-terminal catalytic domain. Mouse embryonic stem cells mutant for this gene are viable, but when introduced into the germ line, cause a recessive lethal phenotype with mutant embryos displaying stunted growth and developmental defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. "
17952,17953d17888
< "Q64368-1","NP_034151.3","deleted in azoospermia-like isoform 1","298","This gene encodes a member of the depleted in azoospermia-like (DAZL) protein family. Members of this family contain an RNA recognition motif, interact with poly A binding proteins, and may be involved in the initiation of translation. The encoded protein is expressed in the cytoplasm of pluripotent stem cells, and in both male and female germ cells, where it is essential for gametogenesis. Disruption of this gene is associated with infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]. "
< "Q6KAQ7-1","NP_001333584.1","ZZ-type zinc finger-containing protein 3 isoform c","409",""
17954a17890,17891
> "O35474-1","NP_001033076.1","EGF-like repeat and discoidin I-like domain-containing protein 3 isoform a precursor","480",""
> "O88890-1","NP_001300617.1","SH2 domain-containing protein 1A isoform 1","144",""
17957a17895
> "Q9WVS6-1","NP_001304655.1","E3 ubiquitin-protein ligase parkin isoform 2","262",""
17959d17896
< "Q8R1B8-2","NP_666207.3","nuclear receptor ROR-beta isoform 2","470","The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]. "
17961d17897
< "Q91YI4-1","NP_663404.1","beta-arrestin-2 isoform b","410",""
17964c17900
< "Q6GQT6-1","NP_001096632.1","sterol regulatory element-binding protein cleavage-activating protein","1276",""
---
> "P28654-1","NP_001177380.1","decorin preproprotein","354","This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate a mature protein product, which is secreted into the extracellular space to regulate collagen fibril assembly. Homozygous knockout mice for this gene exhibit enhanced tumorigenesis in a liver cancer model, and defects in collagen fibrils, leading to weakened skin and tendons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. "
17972c17908,17909
< "P15209-1","NP_032771.1","BDNF/NT-3 growth factors receptor isoform b precursor","476",""
---
> "Q3UX37-1","NP_001028425.1","pleckstrin homology domain-containing family G member 1","1390",""
> "Q8JZR6-1","NP_001334031.1","electroneutral sodium bicarbonate exchanger 1 isoform 2","1037",""
17974,17975c17911,17912
< "P53564-1","NP_034116.3","protein CASP isoform a","1426",""
< "P02340-1","NP_035770.2","cellular tumor antigen p53 isoform a","390","This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]. "
---
> "Q9WTK8-1","NP_001077428.1","meiotic recombination protein SPO11 isoform c","371",""
> "P08730-1","NP_001300878.1","keratin, type I cytoskeletal 13 isoform 2","219","The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
17976a17914
> "Q8CE08-1","NP_062781.2","prostatic acid phosphatase isoform 2 precursor","381",""
17980d17917
< "Q6IRU5-1","NP_083146.1","clathrin light chain B isoform b","211",""
17981a17919
> "Q8BUL6-1","NP_001333444.1","pleckstrin homology domain-containing family A member 1 isoform 2","383",""
17983a17922
> "P02340-1","NP_001120705.1","cellular tumor antigen p53 isoform b","381","This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]. "
17986d17924
< "Q64337-1","NP_035148.1","sequestosome-1 isoform 1","442",""
17988,17990d17925
< "P37172-1","NP_031420.2","activin receptor type-1 precursor","509",""
< "A2CG63-1","NP_937755.1","AT-rich interactive domain-containing protein 4B isoform 2","1227",""
< "P16294-1","NP_032005.1","coagulation factor IX isoform 1 preproprotein","471","This gene encodes a vitamin K-dependent serine protease that plays a critical role in the intrinsic pathway of blood coagulation. The encoded protein is an inactive zymogen that is activated by coagulation factor XIa to generate factor IXa, a heterodimer containing heavy and light chains. In association with factor VIII, membrane phospholipids and calcium ions, factor IXa cleaves the inactive zymogen factor X to generate active factor Xa. Genetic deletion of this gene in mice results in a severe bleeding phenotype. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
17992,17993c17927
< "P37237-1","NP_034335.1","fibroblast growth factor 8 isoform 1 precursor","268",""
< "Q6R0H7-1","NP_963911.1","protein GNAS isoform XXLb1","876","This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, which is commonly found in imprinted genes and correlates with transcript expression. This gene has an antisense transcript. One of the transcripts produced from this locus, and the antisense transcript, are both paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Additional transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2015]. "
---
> "Q8C7G5-1","NP_001335024.1","apolipoprotein A-V precursor","368",""
17995a17930,17932
> "A2APX8-1","NP_001300926.1","sodium channel protein type 1 subunit alpha isoform 1","2009",""
> "Q9Z2C4-1","NP_001300631.1","myotubularin-related protein 1 isoform D","703",""
> "Q02853-1","NP_001293113.1","stromelysin-3 preproprotein","492","This gene encodes a member of the matrix metalloproteinase family of endopeptidases that are involved in remodeling extracellular matrix during, for example, embryonic development and tumor progression. The encoded protein undergoes post-translational proteolytic processing by furin endopeptidase to form an active enzyme. Subcutaneous introduction of cells expressing the encoded protein into nude mice results in increased tumor incidence. Mice lacking the encoded protein exhibit a decreased incidence of chemically-induced tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
17998,17999d17934
< "P17047-1","NP_034815.2","lysosome-associated membrane glycoprotein 2 isoform 2 precursor","415",""
< "Q9CS42-1","NP_080938.1","ribose-phosphate pyrophosphokinase 2 isoform 2","318",""
18002,18003c17937,17938
< "Q8BR86-1","NP_080600.1","kin of IRRE-like protein 3 isoform B precursor","766",""
< "Q60987-1","NP_032267.1","forkhead box protein G1","481",""
---
> "Q8R104-1","NP_001120823.1","NAD-dependent protein deacetylase sirtuin-3 isoform 1","257",""
> "Q9D7M8-1","NP_081278.1","DNA-directed RNA polymerase II subunit RPB4 isoform 1","142",""
18005,18011c17940,17944
< "Q9EP53-1","NP_075025.2","hamartin isoform 2","1160",""
< "Q99JT2-1","NP_598490.1","serine/threonine-protein kinase 26 isoform 1","416",""
< "P08152-1","NP_034248.2","E3 SUMO-protein ligase EGR2 isoform 1","470",""
< "Q9D752-1","NP_082261.2","mitotic spindle assembly checkpoint protein MAD2B","211",""
< "Q3UFB2-1","NP_001333450.1","box C/D snoRNA protein 1 isoform 2","292",""
< "Q8R2G4-5","NP_859417.2","ecto-ADP-ribosyltransferase 3 isoform 2 precursor","361",""
< "P16882-1","NP_034414.2","growth hormone receptor isoform 1 precursor","650",""
---
> "O54839-1","NP_001158261.1","eomesodermin homolog isoform 2","688",""
> "A2AI05-1","NP_001075945.1","NADPH-dependent diflavin oxidoreductase 1 isoform 1","598",""
> "Q8R5M8-1","NP_001020771.1","cell adhesion molecule 1 isoform d precursor","417",""
> "Q9JHB4-1","NP_001277450.1","WD repeat-containing protein 31 isoform 1","367",""
> "Q61216-1","NP_001297657.1","double-strand break repair protein MRE11 isoform 2","679",""
18015a17949,17950
> "O88507-1","NP_001129528.1","ciliary neurotrophic factor receptor subunit alpha preproprotein","372","This gene encodes the alpha subunit of the ciliary neurotrophic factor (CNTF) receptor that triggers the assembly of a trimolecular complex upon binding to CNTF, and initiate a downstream signaling process. The encoded preproprotein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-linked cell surface protein. Mice lacking the encoded protein die shortly after birth and exhibit a reduction of motoneuron number at birth. The transgenic disruption of this gene specifically in the skeletal muscle followed by a peripheral nerve lesion impairs motor neuron axonal regeneration across the lesion site. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2015]. "
> "O35473-1","NP_001317578.1","nuclear nucleic acid-binding protein C1D","141",""
18019,18020d17953
< "Q3TLR7-1","NP_084042.1","denticleless protein homolog isoform 1","729",""
< "Q9QZM3-1","NP_064336.1","cardiotrophin-like cytokine factor 1 isoform 1 precursor","225",""
18021a17955,17959
> "P15209-1","NP_001020245.1","BDNF/NT-3 growth factors receptor isoform a precursor","821",""
> "Q60644-1","NP_001272446.1","oxysterols receptor LXR-beta isoform a","446",""
> "P47936-1","NP_001292207.1","cannabinoid receptor 2","347",""
> "Q06985-1","NP_001295314.1","E3 ubiquitin-protein ligase SIAH1B","282","This gene encodes a member of the seven in absentia homolog (Siah) family of E3 ubiquitin ligase enzymes that catalyze the transfer of ubiquitin to substrate proteins. The encoded protein targets Pard3A (partitioning defective 3A) protein for proteasome-mediated degradation during the exit of cerebellar granule neurons from their germinal zone niche. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]. "
> "Q99J83-1","NP_001300942.1","autophagy protein 5 isoform 2","171","The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Two transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
18023d17960
< "O08605-1","NP_067436.1","MAP kinase-interacting serine/threonine-protein kinase 1 isoform b","415","This gene encodes a serine-threonine protein kinase that is activated by extracellular signal-regulated kinase or p38 mitogen-activated protein kinases, and it may function in cytokine and environmental stress responses. This kinase is required for phosphorylation of eukaryotic translation initiation factor 4E but it is not required for cell growth during development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]. "
18025d17961
< "Q60613-1","NP_033760.2","adenosine receptor A2a","410",""
18028c17964
< "P47936-1","NP_034054.3","cannabinoid receptor 2","347",""
---
> "Q8C863-1","NP_001230641.1","E3 ubiquitin-protein ligase Itchy","864",""
18029a17966,17969
> "Q02566-1","NP_001157643.1","myosin-6","1938",""
> "Q6IRU5-1","NP_001334441.1","clathrin light chain B isoform a","229",""
> "Q9D7Y9-1","NP_001033730.1","protein SLX4IP isoform 1","413",""
> "Q0VEP0-1","NP_001164389.1","olfactory receptor 1507","313","Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. "
18031,18032c17971,17972
< "O54839-1","NP_034266.2","eomesodermin homolog isoform 1","707",""
< "P48678-1","NP_062263.1","prelamin-A/C isoform C2","462","This gene encodes a protein that is a member of the lamin family. Nuclear lamins, intermediate filament-like proteins, are the major components of the nuclear lamina, a protein meshwork associated with the inner nuclear membrane. This meshwork is thought to maintain the integrity of the nuclear envelope, participate in chromatin organization, and regulate gene transcription. Vertebrate lamins consist of two types, A and B. This protein is an A-type and is proposed to be developmentally regulated. In mouse deficiency of this gene is associated with muscular dystrophy. Mouse lines with different mutations in this gene serve as pathophysiological models for several human laminopathies. In humans, mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, May 2013]. "
---
> "P48678-1","NP_001002011.2","prelamin-A/C isoform A precursor","665","This gene encodes a protein that is a member of the lamin family. Nuclear lamins, intermediate filament-like proteins, are the major components of the nuclear lamina, a protein meshwork associated with the inner nuclear membrane. This meshwork is thought to maintain the integrity of the nuclear envelope, participate in chromatin organization, and regulate gene transcription. Vertebrate lamins consist of two types, A and B. This protein is an A-type and is proposed to be developmentally regulated. In mouse deficiency of this gene is associated with muscular dystrophy. Mouse lines with different mutations in this gene serve as pathophysiological models for several human laminopathies. In humans, mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, May 2013]. "
> "Q5FWI2-1","NP_001012322.2","secretin receptor isoform 1 precursor","464",""
18035d17974
< "Q3U3N0-1","NP_081698.2","mesoderm induction early response protein 2 isoform 2","539",""
18038a17978,17980
> "Q91YI4-1","NP_001258287.1","beta-arrestin-2 isoform a","421",""
> "Q9CPV5-1","NP_001297534.1","polyamine-modulated factor 1 isoform 2","133",""
> "Q8QZT4-1","NP_001334337.1","protein crumbs homolog 3 isoform 2","117",""
18040d17981
< "Q02566-1","NP_034986.1","myosin-6","1938",""
18042c17983,17984
< "P97367-1","NP_034955.1","homeobox protein Meis2 isoform 2","470","This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcriptional regulators and several members have been shown to be essential contributors to developmental programs. In mice, a knock-out of this gene leads to lethality at embryonic day 14, accompanied with hemorrhaging. Embryos lacking this gene show defects in tissues derived from the neural crest, suggesting a critical role of this gene during cranial and cardiac neural crest cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. "
---
> "Q64368-1","NP_001264792.1","deleted in azoospermia-like isoform 2","281","This gene encodes a member of the depleted in azoospermia-like (DAZL) protein family. Members of this family contain an RNA recognition motif, interact with poly A binding proteins, and may be involved in the initiation of translation. The encoded protein is expressed in the cytoplasm of pluripotent stem cells, and in both male and female germ cells, where it is essential for gametogenesis. Disruption of this gene is associated with infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]. "
> "Q52KR2-1","NP_001020238.1","leucine-rich repeats and immunoglobulin-like domains protein 2 isoform 1 precursor","1054",""
18047a17990
> "Q920B0-1","NP_001333566.1","FERM domain-containing protein 4B isoform 1","1035",""
18053a17997
> "Q6P1B3-1","NP_001139398.1","PILR alpha-associated neural protein precursor","278",""
18055a18000
> "Q9JLV9-1","NP_001298058.1","prolactin-2C5 isoform 1 precursor","225",""
18059c18004,18005
< "Q8CBH7-1","NP_808265.2","E3 ubiquitin-protein ligase MARCH11 isoform 1","400",""
---
> "O88509-1","NP_001003960.2","DNA (cytosine-5)-methyltransferase 3B isoform 2","839","This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene results in severe developmental defects and loss of viability. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. There is a pseudogene for this gene located adjacent to this gene in the same region of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]. "
> "Q99JT2-1","NP_001300673.1","serine/threonine-protein kinase 26 isoform 2","405",""
18062d18007
< "P20334-1","NP_035742.1","tumor necrosis factor receptor superfamily member 9 isoform 1 precursor","256",""
18064c18009
< "E9PV24-1","NP_034326.1","fibrinogen alpha chain isoform 2 precursor","557","This gene encodes a subunit of the coagulation factor fibrinogen, which is a component of the blood clot. The encoded protein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mice lacking the encoded protein display bleeding in the peritoneal cavity, skin and soft tissues around joints immediately after birth, and are predisposed to spontaneous fatal abdominal hemorrhage as they grow. Pregnant mice lacking the encoded protein succumb to uterine bleeding during gestation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]. "
---
> "P29387-1","NP_001334991.1","guanine nucleotide-binding protein subunit beta-4 isoform 2","340",""
18066,18067c18011,18013
< "Q8BFZ4-1","NP_848789.2","F-box/LRR-repeat protein 21 isoform 1","434",""
< "Q99P58-1","NP_085031.3","ras-related protein Rab-27B isoform 1","218",""
---
> "Q2YDW7-1","NP_001297652.1","N-lysine methyltransferase KMT5A isoform 2","364",""
> "Q60613-1","NP_001318024.1","adenosine receptor A2a","410",""
> "P28230-1","NP_001289425.1","gap junction beta-1 protein","283","This gene is a member of the gap junction protein (connexin) family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of ions and small molecules between cells. Mutations in a similar gene in human cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Oct 2014]. "
18069a18016,18017
> "Q9WTL8-1","NP_001229977.1","aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform 2","613","The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with Clock. This heterodimer binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]. "
> "Q60987-1","NP_001153584.1","forkhead box protein G1","481",""
18071d18018
< "Q9DAQ9-1","NP_083575.1","spermatogenesis-associated protein 19, mitochondrial isoform 1 precursor","154",""
18074,18076c18021
< "P41183-1","NP_033874.1","B-cell lymphoma 6 protein homolog","707",""
< "Q99J83-1","NP_444299.1","autophagy protein 5 isoform 1","275","The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Two transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
< "Q8BSL7-1","NP_031503.1","ADP-ribosylation factor 2","181",""
---
> "P62849-1","NP_035427.2","40S ribosomal protein S24 isoform 1","130",""
18078d18022
< "O35464-1","NP_061214.2","semaphorin-6A isoform 1 precursor","1031",""
18081,18084c18025
< "Q8QZT4-1","NP_808306.1","protein crumbs homolog 3 isoform 1 precursor","113",""
< "Q9D0B6-1","NP_080588.1","protein PBDC1 isoform 1","198",""
< "Q8R2K8-1","NP_705733.2","uncharacterized protein C1orf54 homolog isoform 1 precursor","148",""
< "Q8CE08-1","NP_997551.1","prostatic acid phosphatase isoform 1 precursor","417",""
---
> "Q8CBH7-1","NP_001297703.1","E3 ubiquitin-protein ligase MARCH11 isoform 2","255",""
18086d18026
< "Q7TMB8-1","NP_035500.2","cytoplasmic FMR1-interacting protein 1 isoform a","1253",""
18088d18027
< "P16125-1","NP_032518.1","L-lactate dehydrogenase B chain isoform Ldhb","334","This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have also been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes 1 and 19. [provided by RefSeq, Feb 2016]. "
18091d18029
< "Q8C863-1","NP_032421.2","E3 ubiquitin-protein ligase Itchy","864",""
18094,18095d18031
< "O08807-1","NP_058044.1","peroxiredoxin-4 isoform 2 precursor","274",""
< "P08730-1","NP_034792.1","keratin, type I cytoskeletal 13 isoform 1","437","The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
18098a18035
> "Q8K259-1","NP_001297702.1","gypsy retrotransposon integrase-like protein 1 isoform 2","429",""
18099a18037
> "O89086-1","NP_001159882.1","RNA-binding protein 3 isoform 2","153",""
18101d18038
< "P97929-1","NP_033895.2","breast cancer type 2 susceptibility protein homolog","3329",""
18104c18041
< "Q9JLV5-1","NP_057925.1","cullin-3 isoform 1","768",""
---
> "Q8BR86-1","NP_001177840.1","kin of IRRE-like protein 3 isoform A precursor","778",""
18109,18110c18046
< "Q1W617-1","NP_001300694.1","protein Shroom4 isoform 3","1359",""
< "Q9QXX4-1","NP_056644.1","calcium-binding mitochondrial carrier protein Aralar2 isoform 1","676",""
---
> "Q8VBW5-1","NP_001334169.1","HMG box transcription factor BBX isoform 2","887",""
18112,18114c18048,18050
< "O70293-1","NP_036068.2","G protein-coupled receptor kinase 6 isoform b","560",""
< "Q8R104-1","NP_071878.2","NAD-dependent protein deacetylase sirtuin-3 isoform 1","257",""
< "Q61216-1","NP_061206.1","double-strand break repair protein MRE11 isoform 1","706",""
---
> "Q8C1Z8-1","NP_001335125.1","tRNA methyltransferase 10 homolog A","330",""
> "Q9EP53-1","NP_001276504.1","hamartin isoform 1","1161",""
> "P42227-1","NP_998824.1","signal transducer and activator of transcription 3 isoform 1","770","The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]. "
18116a18053
> "P53564-1","NP_001278162.1","protein CASP isoform c","1613",""
18117a18055
> "Q6X1Y6-1","NP_001297403.1","acid-sensing ion channel 3 isoform 2","440",""
18119,18120d18056
< "O35474-1","NP_034233.1","EGF-like repeat and discoidin I-like domain-containing protein 3 isoform b precursor","470",""
< "P11438-1","NP_034814.2","lysosome-associated membrane glycoprotein 1 isoform 2 precursor","406",""
18125d18060
< "Q9CYK2-1","NP_081731.1","glutaminyl-peptide cyclotransferase isoform 1 precursor","362",""
18130a18066
> "Q9Z131-1","NP_001334514.1","SH3 domain-binding protein 5 isoform 2","456",""
18134d18069
< "P35846-1","NP_032060.2","folate receptor alpha precursor","255",""
18136c18071
< "Q3TL26-1","NP_032275.2","dimethyladenosine transferase 2, mitochondrial isoform 1","396",""
---
> "P20917-1","NP_001333015.1","myelin-associated glycoprotein isoform 3 precursor","582","This gene encodes a type I membrane protein and member of the immunoglobulin-like superfamily. It is expressed in myelinating glial cells, including oligodendrocytes of the central nervous system and Schwann cells of the peripheral nervous system. Mice lacking the encoded protein express abundant myelin, but suffer long-term axon degeneration, altered distribution of channels and adhesion molecules at nodes of Ranvier, and altered axon cytoskeletal structure. While not required for myelination, the encoded protein enhances axon-myelin stability, helps to structure nodes of Ranvier, and regulates the axon cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. "
18137a18073
> "A2ALS5-1","NP_001074624.1","rap1 GTPase-activating protein 1 isoform 1","727",""
18139d18074
< "Q99J64-1","NP_084519.1","RNA-binding protein 43 isoform b","343",""
18142,18144c18077,18080
< "P42866-1","NP_001291884.1","mu-type opioid receptor isoform MOR-1U","474","This gene encodes the mu opioid receptor which is where drugs such as morphine and other opioids have pharmacological effects. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]. "
< "Q80VW7-1","NP_001292361.1","microtubule organization protein AKNA","1404",""
< "O88508-1","NP_714965.1","DNA (cytosine-5)-methyltransferase 3A isoform 2","689","This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]. "
---
> "Q9WTJ4-1","NP_001103798.1","flt3-interacting zinc finger protein 1","500",""
> "Q3V009-1","NP_001311439.1","transmembrane emp24 domain-containing protein 1 isoform 2","185",""
> "Q9CW73-1","NP_001297695.1","galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform 1","347",""
> "Q9DAS4-1","NP_001298054.1","prolactin-8A8 isoform 1 precursor","241",""
18146,18147d18081
< "Q9DB70-1","NP_082334.1","FUN14 domain-containing protein 1 isoform 1","155",""
< "P01326-1","NP_032413.1","insulin-2 preproprotein","110","This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. The encoded precursor protein undergoes proteolytic cleavage to produce a disulfide-linked heterodimeric functional protein that is stored in secretory granules. An increase in blood glucose levels, among others, induces the release of insulin from the secretory granules. Mice deficient in the functional hormone encoded by this gene develop diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. "
18148a18083
> "Q61456-1","NP_001292150.1","cyclin-A1","421",""
18149a18085
> "Q5SRX1-1","NP_001034181.1","TOM1-like protein 2 isoform b","487",""
18151c18087
< "Q9WV30-1","NP_598718.2","nuclear factor of activated T-cells 5 isoform a","1458",""
---
> "P11438-1","NP_001304282.1","lysosome-associated membrane glycoprotein 1 isoform 1 precursor","407",""
18154d18089
< "Q3UMC0-1","NP_067318.2","ATPase family protein 2 homolog isoform 2","892",""
18155a18091
> "Q8VE42-1","NP_001335189.1","ankyrin repeat domain-containing protein 49","238",""
18158,18161c18094,18095
< "Q9WTK8-1","NP_036176.1","meiotic recombination protein SPO11 isoform a","396",""
< "P70188-1","NP_034759.1","kinesin-associated protein 3 isoform KAP3B","772","The protein encoded by this gene is the non-motor subunit of kinesin-2 complex, and forms a heterotrimer with two members of the kinesin superfamily of proteins that together form a microtubule plus-end directed translocator that plays an important role in intracellular transport, mitosis, and cell-cell adhesion. This protein contains multiple armadillo repeats involved in protein binding, and may serve as an adaptor to regulate binding of cargo with the motor proteins. Conditional disruption of this gene in mouse neural precursor cells caused a tumor-like phenotype and defective organization of the neuroepithelium thought to be the result of altered N-cadherin subcellular localization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]. "
< "Q99PP7-1","NP_444400.2","E3 ubiquitin-protein ligase TRIM33 isoform 1","1140",""
< "Q9WTL8-1","NP_031515.1","aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform 1","626","The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with Clock. This heterodimer binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]. "
---
> "O08650-1","NP_001317977.1","hyaluronan synthase 3","554",""
> "O35085-1","NP_001292869.1","homeobox protein ARX","564","This gene encodes a transcription factor that plays an important role in the development of forebrain. Male mice lacking this gene have smaller brains, olfactory bulbs and testes, and die within half a day after birth. Mice lacking this gene specifically in ganglionic eminence-derived neurons, including cortical interneurons, develop seizures. Mutations in this gene have been demonstrated to cause mouse phenotypes resembling human X-linked lissencephaly and cognitive disability with epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
18165a18100,18102
> "Q60715-1","NP_001303300.1","prolyl 4-hydroxylase subunit alpha-1 isoform 2 precursor","534",""
> "Q80U40-1","NP_001074857.1","RIMS-binding protein 2 isoform 1","1079",""
> "Q8R1B8-2","NP_001036819.1","nuclear receptor ROR-beta isoform 1","459","The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]. "
18169c18106
< "Q3UYH7-1","NP_796052.2","beta-adrenergic receptor kinase 2 isoform 1","688",""
---
> "Q9JLC3-1","NP_001333597.1","methionine-R-sulfoxide reductase B1","116","The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2016]. "
18175c18112,18113
< "O70152-1","NP_034202.1","dolichol-phosphate mannosyltransferase subunit 1 isoform 1","260",""
---
> "Q64704-1","NP_001020478.1","syntaxin-3 isoform B","287",""
> "Q3TLR7-1","NP_001292162.1","denticleless protein homolog isoform 2","605",""
18176a18115
> "Q99J64-1","NP_001135453.1","RNA-binding protein 43 isoform b","343",""
18178c18117,18118
< "Q62432-1","NP_034884.2","mothers against decapentaplegic homolog 2 isoform 1","467",""
---
> "Q8BFZ4-1","NP_001333661.1","F-box/LRR-repeat protein 21 isoform 2","460",""
> "Q68FE8-1","NP_001298034.1","zinc finger protein 280D isoform 2","799",""
18181c18121
< "Q8VD24-1","NP_080169.2","zinc finger CCHC domain-containing protein 18","393",""
---
> "P49718-1","NP_001289469.1","DNA replication licensing factor MCM5","734","The protein encoded by this gene is a member of the oligameric minichromosome maintenance protein complex. During DNA replication, the complex loads onto chromatin in early G1 and is converted into an active replicative helicase during S phase. It functions to limit DNA synthesis to once per cell cycle. During embryogenesis, the encoded protein is negatively regulated through expression of paired box protein Pax 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
18183d18122
< "Q6NVE8-1","NP_780389.2","WD repeat-containing protein 44","915","This gene encodes a protein containing multiple WD repeats. The encoded protein may play a role in vesicle trafficking. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]. "
18185d18123
< "Q9QUM7-1","NP_038628.2","mutS protein homolog 5","833","This gene encodes a member of the MutS family of proteins that play critical roles in DNA mismatch repair and meiotic homologous recombination processes. Mice lacking the encoded protein are viable but sterile, with severe defects in spermatogenesis in males and complete loss of ovarian structures in females. Mutations in a similar gene in humans have been shown to cause common variable immune deficiency (CVID) and immunoglobulin A deficiency. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]. "
18186a18125
> "P48540-1","NP_001288261.1","glial cell line-derived neurotrophic factor isoform 2","214","This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Homozygous knockout mice for this gene exhibit defects in kidney development and neonatal death. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]. "
18188c18127
< "Q9R210-1","NP_035679.3","transcription factor EB isoform a","534",""
---
> "P16882-1","NP_001041643.1","growth hormone receptor isoform 2 precursor","297",""
18190d18128
< "Q8C4Y3-1","NP_067368.3","negative elongation factor B isoform 1","628","This gene encodes subunit B of a metazoan-specific, four-subunit protein complex that regulates promoter-proximal pausing of RNA polymerase II. RNA polymerase II pausing is thought to be important for coordination of gene transcription during embryonic development and stress responses. Consistently, disruption of this gene in mouse causes inner cell mass deficiency and embryonic lethality. In addition, this gene is required for maintenance of mouse embryonic stem cells by preventing expression of developmental genes. In adult mice, conditional deletion of this gene results in cardiomyopathy and impaired response to cardiac stress. Multiple protein isoforms are encoded through the use of a non-AUG (CUG) initiation codon and an alternative downstream AUG initiation codon. In addition, alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]. "
18192a18131
> "Q9D906-1","NP_001240646.1","ubiquitin-like modifier-activating enzyme ATG7 isoform 1","741","This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. "
18194,18195d18132
< "Q9QZ88-1","NP_062754.1","vacuolar protein sorting-associated protein 29 isoform 2","182",""
< "P43404-1","NP_033565.2","tyrosine-protein kinase ZAP-70 isoform a","618","This gene encodes a member of the protein tyrosine kinase family. The encoded protein is essential for development of T lymphocytes and thymocytes, and functions in the initial step of T lymphocyte receptor-mediated signal transduction. A mutation in this gene causes chronic autoimmune arthritis, similar to rheumatoid arthritis in humans. Mice lacking this gene are deficient in alpha-beta T lymphocytes in the thymus. In humans, mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T lymphocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. "
18199a18137
> "E9PV24-1","NP_001104518.1","fibrinogen alpha chain isoform 1 preproprotein","789","This gene encodes a subunit of the coagulation factor fibrinogen, which is a component of the blood clot. The encoded protein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mice lacking the encoded protein display bleeding in the peritoneal cavity, skin and soft tissues around joints immediately after birth, and are predisposed to spontaneous fatal abdominal hemorrhage as they grow. Pregnant mice lacking the encoded protein succumb to uterine bleeding during gestation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]. "
18200a18139
> "Q60866-1","NP_001292365.1","phosphotriesterase-related protein isoform 3","260",""
18201a18141
> "Q8BH35-1","NP_001303600.1","complement component C8 beta chain isoform 2 precursor","523","This gene encodes the beta subunit of complement component C8 that participates in the assembly of the complement membrane attack complex. The encoded preproprotein undergoes proteolytic processing to generate the beta subunit, which associates with the alpha and gamma subunits to form a trimeric complement component, C8. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. This gene is located adjacent to the gene encoding the alpha subunit. [provided by RefSeq, Oct 2015]. "
18202a18143
> "Q9CZ96-1","NP_001334026.1","zinc finger CCHC-type and RNA-binding motif-containing protein 1 isoform 2","216",""
18204a18146
> "O08523-1","NP_001311477.1","alpha-tectorin isoform 2 preproprotein","2150",""
18207c18149
< "P16330-1","NP_034053.2","2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform 2","420",""
---
> "Q8C4Y3-1","NP_001297086.1","negative elongation factor B isoform 2","475","This gene encodes subunit B of a metazoan-specific, four-subunit protein complex that regulates promoter-proximal pausing of RNA polymerase II. RNA polymerase II pausing is thought to be important for coordination of gene transcription during embryonic development and stress responses. Consistently, disruption of this gene in mouse causes inner cell mass deficiency and embryonic lethality. In addition, this gene is required for maintenance of mouse embryonic stem cells by preventing expression of developmental genes. In adult mice, conditional deletion of this gene results in cardiomyopathy and impaired response to cardiac stress. Multiple protein isoforms are encoded through the use of a non-AUG (CUG) initiation codon and an alternative downstream AUG initiation codon. In addition, alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]. "
18211,18212c18153
< "Q9QXZ9-1","NP_038915.1","melanopsin isoform 1","521",""
< "Q80U40-1","NP_001297662.1","RIMS-binding protein 2 isoform 2","1071",""
---
> "Q9R210-1","NP_001155194.1","transcription factor EB isoform b","475",""
18214d18154
< "P48540-1","NP_034405.1","glial cell line-derived neurotrophic factor isoform 1","240","This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Homozygous knockout mice for this gene exhibit defects in kidney development and neonatal death. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]. "
18216c18156,18157
< "P03995-1","NP_034407.2","glial fibrillary acidic protein isoform 2","430",""
---
> "O88843-1","NP_001317067.1","death domain-containing protein CRADD","199",""
> "Q62432-1","NP_001239410.1","mothers against decapentaplegic homolog 2 isoform 1","467",""
18217a18159
> "Q9QZ88-1","NP_001334382.1","vacuolar protein sorting-associated protein 29 isoform 1","186",""
18219d18160
< "A2ALS5-1","NP_083839.1","rap1 GTPase-activating protein 1 isoform 3","663",""
18223,18224c18164,18166
< "O35473-1","NP_065583.2","nuclear nucleic acid-binding protein C1D","141",""
< "Q5SRX1-1","NP_694720.2","TOM1-like protein 2 isoform a","507",""
---
> "O35464-1","NP_001298026.1","semaphorin-6A isoform 2 precursor","976",""
> "Q99PP7-1","NP_001073299.1","E3 ubiquitin-protein ligase TRIM33 isoform 2","1123",""
> "Q8BWJ3-1","NP_001171350.1","phosphorylase b kinase regulatory subunit alpha, liver isoform isoform a","1235",""
18226d18167
< "Q8C551-1","NP_033039.2","RAD51-associated protein 1 isoform 1","337",""
18228c18169
< "P49182-1","NP_032249.3","heparin cofactor 2 precursor","478",""
---
> "Q99JB6-1","NP_001186276.1","forkhead box protein P3","429","The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene result in the scurfy phenotype (sf). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. "
18230,18231d18170
< "O88838-1","NP_038567.1","SPRY domain-containing SOCS box protein 2 isoform 1","264","This gene encodes a member of the SSB family of proteins that contain a central SPRY (repeats in splA and ryanodine receptors) domain and a C-terminal SOCS (suppressor of cytokine signaling) box. The encoded protein is an adaptor protein in the E3 ubiquitin ligase complex that ubiquitinates inducible nitric oxide synthase and targets it for proteasomal degradation. Mice lacking the encoded protein exhibit lower blood urea nitrogen levels and mild thrombocytopenia due to reduced platelet production. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. "
< "A2AI05-1","NP_001239470.1","NADPH-dependent diflavin oxidoreductase 1 isoform 2","531",""
18233c18172,18173
< "Q5FWI2-1","NP_001298006.1","secretin receptor isoform 2 precursor","447",""
---
> "Q9Z2B2-1","NP_001159922.1","brain mitochondrial carrier protein 1 isoform 1 precursor","325",""
> "P63058-1","NP_001300912.1","thyroid hormone receptor alpha isoform 1","492","The protein encoded by this gene is one of several nuclear hormone receptors that bind thyroid hormones such as triiodothyronine and thyroxine with high affinity. The encoded protein is a transcription factor that can activate or repress transcription. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]. "
18237,18239c18177
< "Q6P1B3-1","NP_783627.2","PILR alpha-associated neural protein precursor","278",""
< "Q0VEP0-1","NP_065258.2","olfactory receptor 1507","313","Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. "
< "O35085-1","NP_031518.2","homeobox protein ARX","564","This gene encodes a transcription factor that plays an important role in the development of forebrain. Male mice lacking this gene have smaller brains, olfactory bulbs and testes, and die within half a day after birth. Mice lacking this gene specifically in ganglionic eminence-derived neurons, including cortical interneurons, develop seizures. Mutations in this gene have been demonstrated to cause mouse phenotypes resembling human X-linked lissencephaly and cognitive disability with epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. "
---
> "P01326-1","NP_001172012.1","insulin-2 preproprotein","110","This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. The encoded precursor protein undergoes proteolytic cleavage to produce a disulfide-linked heterodimeric functional protein that is stored in secretory granules. An increase in blood glucose levels, among others, induces the release of insulin from the secretory granules. Mice deficient in the functional hormone encoded by this gene develop diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. "
18240a18179
> "P97794-1","NP_001317292.1","ATP-sensitive inward rectifier potassium channel 8 isoform 1","424",""
18245c18184
< "Q7TS68-1","NP_083226.3","putative methyltransferase NSUN6 isoform a","476",""
---
> "P53702-1","NP_001317978.1","cytochrome c-type heme lyase","272",""
18247a18187,18190
> "P46686-1","NP_001039020.1","tubby-related protein 2 isoform 2","562",""
> "Q8BSL7-1","NP_001291503.1","ADP-ribosylation factor 2","181",""
> "P70298-1","NP_001299837.1","homeobox protein cut-like 2","1426","This gene is a member of the Cut family of transcription factors that have multiple DNA binding domains and regulate cell proliferation and differentiation. This gene is primarily expressed in nervous tissues where it controls the proliferation of neuronal precursors, and may play a role in organogenesis earlier during embryonic development. Mice lacking the encoded protein exhibit smaller spinal cords with deficits in neural progenitor development as well as in neuroblast and interneuron differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. "
> "Q6R0H7-1","NP_034439.2","protein GNAS isoform XLas","1133","This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, which is commonly found in imprinted genes and correlates with transcript expression. This gene has an antisense transcript. One of the transcripts produced from this locus, and the antisense transcript, are both paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Additional transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2015]. "
18250,18251c18193
< "P97368-1","NP_032653.2","homeobox protein Meis3 isoform a","378","The protein encoding this gene belongs to the three amino acid loop extension family of homeodomain transcription factors, which play essential roles in many embryonic processes. These proteins are characterized by an atypical homeodomain containing a three amino acid loop extension between helices 1 and 2. Expression of this gene begins during the compaction stage of embryogenesis and continues into the blastocyst stage. This gene is also expressed in pancreatic islet cells and beta-cells and regulates beta-cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]. "
< "Q3V009-1","NP_034874.2","transmembrane emp24 domain-containing protein 1 isoform 1 precursor","227",""
---
> "Q8BJA3-1","NP_001334555.1","homeobox-containing protein 1 isoform 1","420",""
18252a18195
> "Q9QXQ1-1","NP_001334295.1","cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform 1","498",""
18254c18197,18198
< "P61329-1","NP_898887.1","fibroblast growth factor 12 isoform a","243",""
---
> "Q9D4I2-1","NP_001297364.1","meiosis inhibitor protein 1 isoform 2","894",""
> "P16125-1","NP_001289694.1","L-lactate dehydrogenase B chain isoform 2","259","This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have also been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes 1 and 19. [provided by RefSeq, Feb 2016]. "
18258d18201
< "Q8R5C8-1","NP_001334405.1","zinc finger MYND domain-containing protein 11 isoform gamma","602",""
18260,18261c18203
< "Q3UX37-1","NP_001153414.1","pleckstrin homology domain-containing family G member 1","1390",""
< "P39655-1","NP_031466.2","arachidonate 12-lipoxygenase, 12S-type isoform 1","663",""
---
> "Q99P58-1","NP_001076022.1","ras-related protein Rab-27B isoform 1","218",""
18262a18205,18206
> "Q7TSE6-1","NP_001333595.1","serine/threonine-protein kinase 38-like isoform 2","347",""
> "P61329-1","NP_001263348.1","fibroblast growth factor 12 isoform c","207",""
18263a18208
> "Q60841-1","NP_001297393.1","reelin isoform 2 precursor","3459",""
18265c18210
< "Q62393-1","NP_033438.1","tumor protein D52 isoform 5","185",""
---
> "Q76K27-1","NP_001334332.1","beta-galactoside alpha-2,6-sialyltransferase 2","524",""
18266a18212
> "Q8K1S4-1","NP_001298057.1","netrin receptor UNC5A isoform 2 precursor","842",""
18268d18213
< "A2APX8-1","NP_061203.2","sodium channel protein type 1 subunit alpha isoform 2","1998",""
18270a18216,18217
> "O08605-1","NP_001272417.1","MAP kinase-interacting serine/threonine-protein kinase 1 isoform b","415","This gene encodes a serine-threonine protein kinase that is activated by extracellular signal-regulated kinase or p38 mitogen-activated protein kinases, and it may function in cytokine and environmental stress responses. This kinase is required for phosphorylation of eukaryotic translation initiation factor 4E but it is not required for cell growth during development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]. "
> "O54791-1","NP_001291759.1","transcription factor MafF isoform 1","156",""
18272a18220,18221
> "Q3UYH7-1","NP_001272735.1","beta-adrenergic receptor kinase 2 isoform 3","581",""
> "P21619-1","NP_001334069.1","lamin-B2 isoform 2","474","This gene encodes a protein component of the nuclear lamina, which provides a structural framework for the nuclear envelope. Defects in this gene were found to cause abnormalities in the shape of neurons. This locus represents one of two B-type lamin genes that may be partially, but not entirely, functionally redundant in neuronal development. Loss of both B-type lamin genes in keratinocytes results in ichthyosis and a skin barrier defect leading to dehydration. Alternative transcriptional initiation and splicing results in multiple transcript variants and protein isoforms, including an isoform with a shorter N-terminal rod domain that may function in nuclear envelope remodeling during spermatogenesis. A related pseudogene is found on chromosome 5. [provided by RefSeq, Sep 2017]. "
18274d18222
< "Q9CRC9-1","NP_001334292.1","glucosamine-6-phosphate isomerase 2 isoform 2","274",""
18276d18223
< "Q9EPK5-1","NP_598545.2","WW domain-containing transcription regulator protein 1 isoform 2","395","This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]. "
18280a18228,18230
> "Q9Z1N9-1","NP_001074882.1","protein unc-13 homolog B isoform 2","1601",""
> "Q9WV30-1","NP_001273189.1","nuclear factor of activated T-cells 5 isoform c","1225",""
> "P46938-1","NP_001164618.1","transcriptional coactivator YAP1 isoform 1","488","This gene encodes a protein which binds to the SH3 domain of the Yes proto-oncogene product, a tyrosine kinase. This protein contains a WW domain, consisting of four conserved aromatic amino acids including two tryptophan residues. This conserved WW domain is found in various structural, regulatory and signaling molecules in various species, and may play a role in protein-protein interaction. Following cellular damage, phosphorylation of this encoded protein may suppress apoptosis. This protein may be involved in malignant transformation in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]. "
18283,18284c18233,18236
< "Q8R5M8-1","NP_997559.1","cell adhesion molecule 1 isoform b precursor","428",""
< "Q8C190-1","NP_082476.1","VPS9 domain-containing protein 1 isoform 2","649",""
---
> "Q61686-1","NP_001070257.1","chromobox protein homolog 5","191",""
> "Q8R2K8-1","NP_001333443.1","uncharacterized protein C1orf54 homolog isoform 2 precursor","147",""
> "Q6GQT6-1","NP_001001144.2","sterol regulatory element-binding protein cleavage-activating protein","1276",""
> "Q3TL26-1","NP_001317984.1","dimethyladenosine transferase 2, mitochondrial isoform 3","258",""
18285a18238
> "P03995-1","NP_001124492.1","glial fibrillary acidic protein isoform 1","428",""
18291d18243
< "Q60644-1","NP_033499.1","oxysterols receptor LXR-beta isoform a","446",""
18295c18247
< "Q78XR0-1","NP_080236.2","trafficking protein particle complex subunit 6A isoform a","159",""
---
> "P43404-1","NP_001276541.1","tyrosine-protein kinase ZAP-70 isoform TZK","312","This gene encodes a member of the protein tyrosine kinase family. The encoded protein is essential for development of T lymphocytes and thymocytes, and functions in the initial step of T lymphocyte receptor-mediated signal transduction. A mutation in this gene causes chronic autoimmune arthritis, similar to rheumatoid arthritis in humans. Mice lacking this gene are deficient in alpha-beta T lymphocytes in the thymus. In humans, mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T lymphocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. "
18297c18249
< "P46686-1","NP_032833.2","tubby-related protein 2 isoform 1","562",""
---
> "P97367-1","NP_001129544.1","homeobox protein Meis2 isoform 1","394","This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcriptional regulators and several members have been shown to be essential contributors to developmental programs. In mice, a knock-out of this gene leads to lethality at embryonic day 14, accompanied with hemorrhaging. Embryos lacking this gene show defects in tissues derived from the neural crest, suggesting a critical role of this gene during cranial and cardiac neural crest cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. "
18299a18252
> "P37172-1","NP_001103674.1","activin receptor type-1 precursor","509",""
18301,18306c18254,18256
< "Q8BXA0-1","NP_848829.2","leucine-rich repeat and fibronectin type-III domain-containing protein 5 isoform 1 precursor","746",""
< "O08796-1","NP_031934.1","eukaryotic elongation factor 2 kinase","724",""
< "Q3U7U3-1","NP_694875.2","F-box only protein 7 isoform 1","523",""
< "Q9QZB6-1","NP_056558.1","nuclear receptor subfamily 4 group A member 3 isoform 1","627","This gene encodes a member of the NR4A subfamily of nuclear hormone receptors that bind to DNA and modulate gene expression. The encoded protein has been implicated in T and B lymphocyte apoptosis, and immune cell proliferation. Mice lacking the encoded protein exhibit partial bidirectional circling behavior and inner ear dysfunction. Disruption of this gene in mice also results in defective hippocampal axonal growth and postnatal neuronal cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. "
< "Q791V5-1","NP_062732.1","mitochondrial carrier homolog 2 isoform 1","303","This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]. "
< "P36898-1","NP_031586.1","bone morphogenetic protein receptor type-1B isoform a precursor","502","This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type I receptor, and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important in skeletal and bone development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. "
---
> "P81615-1","NP_001332939.1","urocortin preproprotein","122","This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. Mice lacking the encoded protein exhibit a heightened anxiety-like behaviors and a significantly reduced acoustic startle response. [provided by RefSeq, Sep 2016]. "
> "Q8K0L9-1","NP_001272734.1","zinc finger and BTB domain-containing protein 20 isoform L","741",""
> "Q9EPK5-1","NP_001161753.1","WW domain-containing transcription regulator protein 1 isoform 1","452","This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]. "
18307a18258
> "P35846-1","NP_001239481.1","folate receptor alpha precursor","255",""
18309d18259
< "Q9WVS6-1","NP_057903.1","E3 ubiquitin-protein ligase parkin isoform 1","464",""
18312,18314c18262
< "Q8BWJ3-1","NP_766371.1","phosphorylase b kinase regulatory subunit alpha, liver isoform isoform a","1235",""
< "Q8CA95-1","NP_035996.2","cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 2","796",""
< "Q60866-1","NP_032987.1","phosphotriesterase-related protein isoform 2","349",""
---
> "Q6P3Y5-1","NP_001160120.1","zinc finger protein 280C isoform 1","742",""
18316c18264
< "Q8K2K6-4","NP_034602.1","arf-GAP domain and FG repeat-containing protein 1 isoform 1","559",""
---
> "Q8BXA0-1","NP_001297515.1","leucine-rich repeat and fibronectin type-III domain-containing protein 5 isoform 2 precursor","719",""
18317a18266
> "Q9ERU3-1","NP_001289368.1","zinc finger protein 22","237","This gene encodes a putative C2H2 zinc finger transcription factor that may play a role in tooth development. A pseudogene related to this gene is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
18320d18268
< "O54791-1","NP_034885.1","transcription factor MafF isoform 1","156",""
18322c18270
< "O88509-1","NP_034198.3","DNA (cytosine-5)-methyltransferase 3B isoform 3","776","This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene results in severe developmental defects and loss of viability. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. There is a pseudogene for this gene located adjacent to this gene in the same region of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]. "
---
> "P28705-1","NP_001153203.1","retinoic acid receptor RXR-gamma isoform 2","340",""
18331d18278
< "Q8K259-1","NP_080526.2","gypsy retrotransposon integrase-like protein 1 isoform 1","518",""
18334,18335d18280
< "Q2YDW7-1","NP_084517.2","N-lysine methyltransferase KMT5A isoform 1.","350",""
< "P97765-1","NP_001334571.1","WW domain-binding protein 2 isoform 2","216",""
18336a18282
> "P70188-1","NP_001292572.1","kinesin-associated protein 3 isoform KAP3A","793","The protein encoded by this gene is the non-motor subunit of kinesin-2 complex, and forms a heterotrimer with two members of the kinesin superfamily of proteins that together form a microtubule plus-end directed translocator that plays an important role in intracellular transport, mitosis, and cell-cell adhesion. This protein contains multiple armadillo repeats involved in protein binding, and may serve as an adaptor to regulate binding of cargo with the motor proteins. Conditional disruption of this gene in mouse neural precursor cells caused a tumor-like phenotype and defective organization of the neuroepithelium thought to be the result of altered N-cadherin subcellular localization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]. "
18338d18283
< "Q9JHB4-1","NP_076086.1","WD repeat-containing protein 31 isoform 1","367",""
18340c18285,18286
< "Q80TH2-3","NP_001276404.1","erbin isoform 5","1411",""
---
> "Q80VC9-1","NP_001334040.1","calmodulin-regulated spectrin-associated protein 3 isoform 3","1279",""
> "P17047-1","NP_001017959.1","lysosome-associated membrane glycoprotein 2 isoform 1 precursor","415",""
18342,18345d18287
< "Q9R0C8-1","NP_666251.1","guanine nucleotide exchange factor VAV3 isoform 2","287",""
< "Q61686-1","NP_031652.1","chromobox protein homolog 5","191",""
< "Q3UHN9-1","NP_032332.2","bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1","882",""
< "Q68FF0-1","NP_082136.2","uncharacterized protein KIAA1841 isoform 1","718",""
18351a18294
> "Q9Z1P5-1","NP_001292098.1","CD320 antigen isoform 2 precursor","246",""
18353c18296
< "O88843-1","NP_034080.1","death domain-containing protein CRADD","199",""
---
> "Q80TH2-3","NP_001005868.1","erbin isoform 1","1450",""
18356,18358c18299,18301
< "O88890-1","NP_035494.1","SH2 domain-containing protein 1A isoform 2","126",""
< "P28654-1","NP_031859.1","decorin preproprotein","354","This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate a mature protein product, which is secreted into the extracellular space to regulate collagen fibril assembly. Homozygous knockout mice for this gene exhibit enhanced tumorigenesis in a liver cancer model, and defects in collagen fibrils, leading to weakened skin and tendons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. "
< "Q68FE8-1","NP_666336.3","zinc finger protein 280D isoform 1","974",""
---
> "Q3U3N0-1","NP_001303628.1","mesoderm induction early response protein 2 isoform 1","541",""
> "Q9WVF6-1","NP_001334159.1","group IID secretory phospholipase A2 isoform 2","118",""
> "P42866-1","NP_001034741.1","mu-type opioid receptor isoform MOR-1C","438","This gene encodes the mu opioid receptor which is where drugs such as morphine and other opioids have pharmacological effects. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]. "
18360a18304,18305
> "Q8BUG5-1","NP_001297604.1","calcyphosin-2 isoform 2","550",""
> "Q6PCQ0-1","NP_001334446.1","IQ domain-containing protein E isoform 2","761",""
18365a18311,18312
> "O08796-1","NP_001254639.1","eukaryotic elongation factor 2 kinase","724",""
> "Q9R0C8-1","NP_065251.2","guanine nucleotide exchange factor VAV3 isoform 1","847",""
18369,18372c18316,18318
< "Q8BM92-1","NP_766441.1","cadherin-7 isoform 1 preproprotein","785","This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene is located adjacent to a related cadherin gene on chromosome 1. [provided by RefSeq, Oct 2015]. "
< "P13864-1","NP_034196.5","DNA (cytosine-5)-methyltransferase 1 isoform 2","1619","This gene encodes a methyltransferase that preferentially methylates cytosines of CpG residues in hemimethylated DNA to generate fully methylated CpG base pairs during DNA replication. This enzyme plays roles in diverse cellular processes including cell cycle regulation, DNA repair, and telomere maintenance. The encoded protein is composed of an N-terminal domain with a nuclear localization sequence and replication fork-targeting domain, a DNA-binding CXXC domain, two bromo-adjacent homology domains, and a C-terminal catalytic domain. Mouse embryonic stem cells mutant for this gene are viable, but when introduced into the germ line, cause a recessive lethal phenotype with mutant embryos displaying stunted growth and developmental defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. "
< "Q00417-1","NP_033357.1","transcription factor 7","303","This gene encodes a transcription factor which is a member of the T-cell specific transcription factor family. The encoded protein is distinct from the hepatic transcription factor, transcription factor 1, which is also referred to by the symbol Tcf1. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]. "
< "Q9Z1F6-1","NP_034831.2","leukocyte cell-derived chemotaxin 1 isoform 2","334",""
---
> "Q9DB70-1","NP_001300674.1","FUN14 domain-containing protein 1 isoform 2","112",""
> "Q9QZM3-1","NP_001296967.1","cardiotrophin-like cytokine factor 1 isoform 2 precursor","215",""
> "P39655-1","NP_001318047.1","arachidonate 12-lipoxygenase, 12S-type isoform 2","500",""
18374c18320
< "Q9QXQ1-1","NP_038903.3","cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform 2","446",""
---
> "Q9D773-1","NP_001303671.1","39S ribosomal protein L2, mitochondrial isoform 2","276",""
18377c18323,18324
< "O35618-1","NP_032601.2","protein Mdm4 isoform 2","489","This gene encodes a protein that has been shown to negatively regulate the activity of the tumor suppressor protein p53. Homozygous knockout mice exhibit embryonic lethality as a result of p53-dependent apoptosis and cell cycle arrest. Amplification of this gene or overexpression of the encoded protein has been linked to a range of human cancers. A pseudogene has been identified on the X chromosome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]. "
---
> "A2CG63-1","NP_919238.1","AT-rich interactive domain-containing protein 4B isoform 1","1314",""
> "Q64337-1","NP_001277698.1","sequestosome-1 isoform 2","404",""
18380c18327,18328
< "Q52KR2-1","NP_001297627.1","leucine-rich repeats and immunoglobulin-like domains protein 2 isoform 2 precursor","1047",""
---
> "Q9Z1F6-1","NP_001297584.1","leukocyte cell-derived chemotaxin 1 isoform 1","338",""
> "Q9QXZ9-1","NP_001122071.1","melanopsin isoform 2","466",""
18382d18329
< "P97794-1","NP_032454.1","ATP-sensitive inward rectifier potassium channel 8 isoform 1","424",""
18385a18333
> "Q8BLB7-1","NP_001334396.1","lethal(3)malignant brain tumor-like protein 3 isoform 2","858",""
18386a18335
> "Q3TY92-1","NP_001334100.1","methyl-CpG-binding domain protein 6 isoform 2","1003",""
18388,18390c18337,18338
< "P63058-1","NP_835161.1","thyroid hormone receptor alpha isoform 2","410","The protein encoded by this gene is one of several nuclear hormone receptors that bind thyroid hormones such as triiodothyronine and thyroxine with high affinity. The encoded protein is a transcription factor that can activate or repress transcription. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]. "
< "Q9ERU3-1","NP_080333.1","zinc finger protein 22","237","This gene encodes a putative C2H2 zinc finger transcription factor that may play a role in tooth development. A pseudogene related to this gene is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
< "Q8K2Q9-1","NP_780381.1","shootin-1 isoform 2","456",""
---
> "Q8C190-1","NP_001297590.1","VPS9 domain-containing protein 1 isoform 1","650",""
> "O88838-1","NP_001292979.1","SPRY domain-containing SOCS box protein 2 isoform 1","264","This gene encodes a member of the SSB family of proteins that contain a central SPRY (repeats in splA and ryanodine receptors) domain and a C-terminal SOCS (suppressor of cytokine signaling) box. The encoded protein is an adaptor protein in the E3 ubiquitin ligase complex that ubiquitinates inducible nitric oxide synthase and targets it for proteasomal degradation. Mice lacking the encoded protein exhibit lower blood urea nitrogen levels and mild thrombocytopenia due to reduced platelet production. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. "
18392,18393d18339
< "P32848-1","NP_038673.2","parvalbumin alpha","110",""
< "Q6P3Y5-1","NP_705760.2","zinc finger protein 280C isoform 1","742",""
18396a18343
> "Q8BY46-1","NP_001161978.1","zinc finger protein 574","900",""
18398c18345
< "Q9CWY9-1","NP_081462.1","RPA-interacting protein isoform 1","219",""
---
> "O08759-1","NP_035798.2","ubiquitin-protein ligase E3A isoform 2","870",""
18400d18346
< "Q8BUJ9-1","NP_766402.1","low-density lipoprotein receptor-related protein 12 isoform 1 precursor","858",""
18405a18352
> "Q9CWY9-1","NP_001239342.1","RPA-interacting protein isoform 3","172",""
18413d18359
< "Q9D2H6-1","NP_084496.2","transcription factor Sp2 isoform 1","613","This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. The protein can act as a transcriptional activator or repressor, depending on the promoter and cell type. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. "
18422a18369
> "Q9D1N9-1","NP_001334349.1","39S ribosomal protein L21, mitochondrial isoform 2","209",""
18436a18384
> "Q3UHR0-1","NP_001334550.1","BAH and coiled-coil domain-containing protein 1 isoform 2","2643",""
18438a18387
> "Q9JJI8-1","NP_001041522.1","60S ribosomal protein L38","70",""
18445d18393
< "Q8C827-1","NP_033588.2","zinc finger protein 62 isoform 1","914",""
18450c18398
< "P70378-1","NP_034328.1","fibroblast growth factor 11 isoform 1","225",""
---
> "Q9ESV0-1","NP_001152974.1","ATP-dependent RNA helicase DDX24 isoform 1","903",""
18465d18412
< "Q8R179-1","NP_080267.1","kelch repeat and BTB domain-containing protein 4 isoform 2","518",""
18478a18426
> "Q99NE5-1","NP_001012641.1","regulating synaptic membrane exocytosis protein 1 isoform 3","1374",""
18480c18428
< "Q9CZ83-1","NP_080311.1","39S ribosomal protein L55, mitochondrial isoform 2 precursor","127",""
---
> "Q8BT07-1","NP_001157834.1","centrosomal protein of 55 kDa isoform 1","462",""
18482a18431
> "Q8BJW5-1","NP_001154801.1","nucleolar protein 11 isoform 2","703",""
18486a18436
> "Q9CZ83-1","NP_001289263.1","39S ribosomal protein L55, mitochondrial isoform 1","134",""
18492c18442
< "Q9Z1G4-1","NP_058616.1","V-type proton ATPase 116 kDa subunit a isoform 1 isoform 1","838",""
---
> "Q8C827-1","NP_001020017.1","zinc finger protein 62 isoform 2","907",""
18498d18447
< "O08576-1","NP_058039.1","RUN domain-containing protein 3A isoform 1","446",""
18500d18448
< "Q8BJW5-1","NP_598463.2","nucleolar protein 11 isoform 1","723",""
18509d18456
< "Q8VD72-1","NP_938053.1","tetratricopeptide repeat protein 8 isoform 1","515",""
18512d18458
< "Q8BVA5-1","NP_765989.3","lipid droplet-associated hydrolase isoform 1","326",""
18514d18459
< "Q8BHZ0-1","NP_084034.2","protein FAM49A","323",""
18518d18462
< "P97378-1","NP_032380.1","interleukin-12 receptor subunit beta-2 isoform 1 precursor","874",""
18533c18477
< "Q9CZI9-1","NP_080807.3","apoptosis-enhancing nuclease isoform 1","336",""
---
> "Q8K3P5-1","NP_001277670.1","CCR4-NOT transcription complex subunit 6 isoform 1","557",""
18539a18484
> "Q60996-1","NP_001074926.1","serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform b","485",""
18543a18489
> "C0HKG6-1","NP_001077407.1","ribonuclease T2-A isoform 1 precursor","259",""
18550a18497
> "Q6P5G3-1","NP_001333454.1","MBT domain-containing protein 1 isoform 2","622",""
18557c18504
< "Q9Z1X0-1","NP_035466.1","C-C motif chemokine 27 isoform 2 precursor","120",""
---
> "P97765-1","NP_058548.1","WW domain-binding protein 2 isoform 1","261",""
18558a18506
> "Q9D4H9-1","NP_001161854.1","PHD finger protein 14 isoform 1","941",""
18562d18509
< "Q69ZR9-1","NP_083221.1","protein TASOR isoform 2","1498",""
18564d18510
< "Q8K1S4-1","NP_694771.1","netrin receptor UNC5A isoform 1 precursor","898",""
18567d18512
< "Q7M6Y3-1","NP_666306.2","phosphatidylinositol-binding clathrin assembly protein isoform 1","660",""
18589d18533
< "Q9WVF6-1","NP_035239.1","group IID secretory phospholipase A2 isoform 1 precursor","144",""
18595a18540
> "Q7TN33-1","NP_001298021.1","CUGBP Elav-like family member 6 isoform 2","344",""
18601d18545
< "Q8BY46-1","NP_780686.1","zinc finger protein 574","900",""
18610d18553
< "Q9ET39-1","NP_109635.1","SLAM family member 6 isoform 1 precursor","331",""
18614d18556
< "Q9D1N9-1","NP_758456.2","39S ribosomal protein L21, mitochondrial isoform 1","216",""
18624a18567
> "Q3UHU5-1","NP_001107570.1","microtubule cross-linking factor 1 isoform 1","1893",""
18627c18570
< "Q3UHR0-1","NP_940815.3","BAH and coiled-coil domain-containing protein 1 isoform 1","2643",""
---
> "A8Y5H7-1","NP_001159978.1","SEC14-like protein 1 isoform 2","715",""
18629a18573
> "Q8BHZ0-1","NP_001139591.1","protein FAM49A","323",""
18632d18575
< "P22723-1","NP_803127.3","gamma-aminobutyric acid receptor subunit gamma-2 isoform 2 precursor","466","This gene encodes a gamma-aminobutyric acid (GABA)-A receptor subunit, which is a member of the ligand-gated ion channel family. GABA is the major inhibitory neurotransmitter in the adult central nervous system, and conversely exhibits an excitatory function during development. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. This gene encodes one of three gamma subunits in mammals, which contain the binding site for benzodiazepine drugs. Several mutations in this gene are associated with epileptic seizures, and genetic knockdown is associated with anxiety behavior. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
18634a18578
> "P42232-1","NP_001107035.1","signal transducer and activator of transcription 5B","786",""
18645,18646c18589
< "Q9D4H9-1","NP_083680.2","PHD finger protein 14 isoform 2","881",""
< "Q9CZ96-1","NP_080301.1","zinc finger CCHC-type and RNA-binding motif-containing protein 1 isoform 1","217",""
---
> "Q00417-1","NP_001300910.1","transcription factor 7","303","This gene encodes a transcription factor which is a member of the T-cell specific transcription factor family. The encoded protein is distinct from the hepatic transcription factor, transcription factor 1, which is also referred to by the symbol Tcf1. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]. "
18647a18591
> "P22723-1","NP_032099.1","gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor","474","This gene encodes a gamma-aminobutyric acid (GABA)-A receptor subunit, which is a member of the ligand-gated ion channel family. GABA is the major inhibitory neurotransmitter in the adult central nervous system, and conversely exhibits an excitatory function during development. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. This gene encodes one of three gamma subunits in mammals, which contain the binding site for benzodiazepine drugs. Several mutations in this gene are associated with epileptic seizures, and genetic knockdown is associated with anxiety behavior. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. "
18653d18596
< "Q3UHI0-1","NP_082683.2","serine-rich coiled-coil domain-containing protein 2 isoform 2","485",""
18659d18601
< "Q99NE5-1","NP_898839.2","regulating synaptic membrane exocytosis protein 1 isoform 2","1435",""
18662c18604
< "Q8K023-1","NP_598827.1","aldo-keto reductase family 1 member C18 isoform 1","323",""
---
> "O08576-1","NP_001239276.1","RUN domain-containing protein 3A isoform 2","413",""
18665a18608,18609
> "P70378-1","NP_001278033.1","fibroblast growth factor 11 isoform 2","197",""
> "Q8VD72-1","NP_083829.1","tetratricopeptide repeat protein 8 isoform 2","505",""
18673a18618
> "O35250-1","NP_001156344.1","exocyst complex component 7 isoform 2","653",""
18684a18630
> "Q9D2H6-1","NP_001074433.1","transcription factor Sp2 isoform 2","612","This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. The protein can act as a transcriptional activator or repressor, depending on the promoter and cell type. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. "
18690d18635
< "Q9DAS4-1","NP_076230.1","prolactin-8A8 isoform 2 precursor","240",""
18694a18640
> "Q9JHG7-1","NP_001139672.1","phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform","1102",""
18697a18644
> "Q9JIM3-1","NP_001013626.2","DNA excision repair protein ERCC-6-like 2 isoform 1","1537",""
18705c18652,18653
< "O35250-1","NP_058553.2","exocyst complex component 7 isoform 1","697",""
---
> "Q8BGU2-1","NP_001289285.1","cerebellin-2 precursor","224","The protein encoded by this gene belongs to a family of secreted neuronal glycoproteins. The transcript is broadly expressed in the embryonic and adult brain with higher levels in some regions including the olfactory bulb, thalamus, and cerebral cortex. The protein can bind to presynaptic neurexins and induce synaptogenesis in cultured neurons. Null mutant mice are viable, fertile and do not display obvious neuroanatomical defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. "
> "Q7M6Y3-1","NP_001239449.1","phosphatidylinositol-binding clathrin assembly protein isoform 2","655",""
18710d18657
< "Q9JJI8-1","NP_075861.1","60S ribosomal protein L38","70",""
18715,18716d18661
< "A8Y5H7-1","NP_083053.2","SEC14-like protein 1 isoform 1","719",""
< "Q9JIY2-1","NP_598809.1","E3 ubiquitin-protein ligase Hakai isoform 2","490",""
18718d18662
< "Q8VDI1-1","NP_849147.1","epithelial-stromal interaction protein 1 isoform b","229",""
18720d18663
< "Q9QYY8-1","NP_058658.2","spastin isoform 2","613",""
18721a18665,18669
> "Q8CJ53-1","NP_001229318.1","cdc42-interacting protein 4 isoform 1","603",""
> "Q91X46-1","NP_001276615.1","rho guanine nucleotide exchange factor 3 isoform 1","551",""
> "Q99PR8-1","NP_001158180.1","heat shock protein beta-2 isoform 2","88",""
> "Q64739-2","NP_001304651.1","collagen alpha-2(XI) chain isoform 1 precursor","1715","This gene encodes the alpha-2 subunit of type XI collagen, one of the low abundance fibrillar collagens found in cartilage. The encoded protein, in association with other collagen subunits, forms a heterotrimeric type XI procollagen that may undergo proteolytic processing similar to the alpha-1 subunit. Mice lacking the encoded protein exhibit a mild phenotype similar to nonocular Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED) as well as a nonsyndromic form of deafness called DFNA13. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]. "
> "Q9CYK2-1","NP_001303658.1","glutaminyl-peptide cyclotransferase isoform 2","313",""
18723,18724c18671,18674
< "O35719-1","NP_033040.2","DNA repair protein RAD51 homolog 2 isoform 1","350",""
< "Q99LI8-1","NP_032270.3","hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2","775",""
---
> "Q80W14-1","NP_001335185.1","pre-mRNA-processing factor 40 homolog B isoform 1","870",""
> "Q80YE7-1","NP_001272846.1","death-associated protein kinase 1 isoform 2","1442",""
> "Q8K097-1","NP_001033747.1","protein lifeguard 2 isoform 2","305",""
> "Q80X44-1","NP_001264158.1","zinc finger and BTB domain-containing protein 24 isoform 2","688","This gene encodes a protein containing eight C2H2-type zinc fingers and a BTB domain. Expression of this gene is induced by bone morphogenetic protein-2 signaling. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies syndrome-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. "
18726a18677
> "Q9Z1J2-1","NP_001295257.1","serine/threonine-protein kinase Nek4 isoform 2","744",""
18727a18679,18680
> "Q8BQR4-1","NP_001276366.1","KAT8 regulatory NSL complex subunit 2 isoform b","452",""
> "O54910-1","NP_001291885.1","NF-kappa-B inhibitor epsilon isoform 2","371",""
18729,18734c18682,18692
< "Q3TT38-1","NP_001258440.1","protein ILRUN isoform 3","238",""
< "Q9CZX0-1","NP_083087.1","elongator complex protein 3 isoform 2","547",""
< "Q8CI96-1","NP_780587.1","CAP-Gly domain-containing linker protein 4 isoform 2","551",""
< "Q80TP3-1","NP_001106192.1","E3 ubiquitin-protein ligase UBR5 isoform 2","2792",""
< "Q3UQU0-1","NP_001294970.1","bromodomain-containing protein 9 isoform 2","596",""
< "Q6PAV2-1","NP_084390.1","probable E3 ubiquitin-protein ligase HERC4 isoform 1","1057",""
---
> "P63137-1","NP_001334243.1","gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor","512",""
> "Q9WV69-1","NP_001239591.1","dematin isoform 1","405",""
> "Q8CA95-1","NP_001277636.1","cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 1","850",""
> "Q6NZK8-1","NP_001288710.1","protein tyrosine phosphatase domain-containing protein 1 isoform 1","808","The protein encoded by this gene is a centrosomal mitotic phosphatase. This protein has been implicated in centrosomal duplication and cytokinesis. In addition, knockdown of expression levels in non-cycling cells results in extra long cilia, suggesting that this protein may function in regulating cilia length independent of a function in cell cycle control. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]. "
> "Q6PIP5-1","NP_001107026.1","nudC domain-containing protein 1 isoform 2","581",""
> "G3X9G7-1","NP_001158096.1","zinc finger protein 809 isoform 2","354",""
> "Q9WVL0-1","NP_001239484.1","maleylacetoacetate isomerase isoform 2","161",""
> "Q8VI67-1","NP_001335134.1","transcription factor Sp7 isoform 2","410",""
> "P55088-1","NP_001295570.1","aquaporin-4 isoform M23","301","This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]. "
> "Q76LL6-1","NP_001276583.1","FH1/FH2 domain-containing protein 3 isoform 2","1427",""
> "Q7TNJ0-1","NP_001276437.1","dendritic cell-specific transmembrane protein isoform 3","414",""
18735a18694,18696
> "E9Q5C9-1","NP_001034440.1","nucleolar and coiled-body phosphoprotein 1 isoform B","700",""
> "Q8VHI5-1","NP_001183957.1","vitrin isoform 2","628",""
> "P51125-1","NP_001288082.1","calpastatin isoform 1","788","This gene encodes an inhibitor of the calcium-dependent cysteine protease, calpain. This protein plays roles in multiple processes, including apoptosis, cell cycle regulation, and membrane fusion. Multiple protein isoforms exist which contain unique N-terminal domains, and multiple inhibitory domains that share homology with each other. Some isoforms may be tissue-specific. Two different pseudogenes of this gene are found on chromosome 19. [provided by RefSeq, Jul 2014]. "
18739c18700,18701
< "P20917-1","NP_001333014.1","myelin-associated glycoprotein isoform 1 precursor","627","This gene encodes a type I membrane protein and member of the immunoglobulin-like superfamily. It is expressed in myelinating glial cells, including oligodendrocytes of the central nervous system and Schwann cells of the peripheral nervous system. Mice lacking the encoded protein express abundant myelin, but suffer long-term axon degeneration, altered distribution of channels and adhesion molecules at nodes of Ranvier, and altered axon cytoskeletal structure. While not required for myelination, the encoded protein enhances axon-myelin stability, helps to structure nodes of Ranvier, and regulates the axon cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. "
---
> "Q9CZN7-1","NP_001239245.1","serine hydroxymethyltransferase, mitochondrial isoform 2","501",""
> "P46656-1","NP_001288657.1","adrenodoxin, mitochondrial isoform 2 precursor","166","Ferrodoxins are iron-sulfur proteins that facilitate monooxygenase reactions catalyzed by P450 enzymes. The protein encoded by this gene is present in the mitochondrial matrix and transfers electrons from ferredoxin reductase to steroidogenic mitochondrial cytochrome P450 proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]. "
18742,18743c18704,18707
< "P28704-1","NP_035436.1","retinoic acid receptor RXR-beta isoform 2","520",""
< "Q2PFD7-1","NP_808366.2","PH and SEC7 domain-containing protein 3 isoform 2","1004",""
---
> "Q9Z204-1","NP_001164452.1","heterogeneous nuclear ribonucleoproteins C1/C2 isoform 2","300",""
> "Q99L20-1","NP_001333452.1","glutathione S-transferase theta-3 isoform 2","200",""
> "P48725-1","NP_001269921.1","pericentrin isoform b","2898",""
> "Q8BL97-1","NP_001182414.1","serine/arginine-rich splicing factor 7 isoform 2","235","The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Five transcript variants, four of them protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]. "
18746c18710,18713
< "Q9D411-1","NP_001240817.1","testis-specific serine/threonine-protein kinase 4 isoform 3","338",""
---
> "Q8BVF4-1","NP_001257364.1","coiled-coil domain-containing protein 30 isoform b","649",""
> "Q8BRT1-1","NP_001273528.1","CLIP-associating protein 2 isoform d","400",""
> "Q9Z0E2-1","NP_001264970.1","chordin isoform 2 precursor","970",""
> "Q8BGF7-1","NP_001239255.1","PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 2","1191",""
18749,18751c18716
< "E9Q5C9-1","NP_444316.2","nucleolar and coiled-body phosphoprotein 1 isoform A","701",""
< "O88834-1","NP_033194.1","SH2 domain-containing adapter protein D isoform 2","343",""
< "Q6P902-1","NP_705739.2","thioredoxin domain-containing protein 2 isoform 2","543",""
---
> "Q8BHR2-1","NP_001240688.1","ecto-NOX disulfide-thiol exchanger 1 isoform 1","662",""
18754,18756c18719,18726
< "P43029-1","NP_038555.1","growth/differentiation factor 7 isoform 2 preproprotein","453","This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. Mice lacking a functional copy of this gene exhibit absence of some spinal dopaminergic neurons and brain defects, male sterility, and premature death. [provided by RefSeq, Sep 2016]. "
< "Q5XJV7-1","NP_766593.1","histone-lysine N-methyltransferase SETD5 isoform 2","1460",""
< "Q9EPU0-1","NP_109605.2","regulator of nonsense transcripts 1 isoform b","1113",""
---
> "P47867-1","NP_001158262.1","secretogranin-3 isoform 2 precursor","466",""
> "Q8R5H1-1","NP_001288557.1","ubiquitin carboxyl-terminal hydrolase 15 isoform 2","952","The protein encoded by this gene is a member of the large ubiquitin specific protease (Usp) family of proteins. These proteins are known to cleave ubiquitin, and contain a conserved cysteine residue (Cys box) and two conserved histidine residues (His box) that are thought to form part of the active site of the protease. This protein has been shown to cleave both the ubiquitin-proline and the ubiquitin-methionine bonds in vitro. This protein is thought to regulate many cellular processes through its deubiquitination activity, including the transforming growth factor beta (TGF-beta) pathway. Cardiac-specific overexpression of the human ortholog of this gene in mice causes enlargement of the heart that is more pronounced in the atrium than in the ventricle. This gene has two pseudogenes on chromosome 14. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms.[provided by RefSeq, Aug 2014]. "
> "P35951-1","NP_001239587.1","low-density lipoprotein receptor isoform 2 precursor","810",""
> "Q9QYS9-1","NP_001152988.1","protein quaking isoform 2","319",""
> "Q6P1F6-1","NP_001192117.1","serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 2","367",""
> "Q64387-1","NP_001192004.1","prepronociceptin isoform 2 preproprotein","212","This gene encodes the precursor for neuropeptides that have been implicated in a wide range of physiological roles such as transmission and sensitivity to pain, learning, memory, anxiety and depression, in the central nervous system. The encoded protein is a precursor that is proteolytically processed to generate multiple biologically active peptides including nociceptin and nocistatin which have opposite functions in pain transmission. Mice lacking the encoded protein display increased anxiety, elevated basal pain threshold and impaired adaptation to repeated stress. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]. "
> "P38532-1","NP_001318083.1","heat shock factor protein 1 isoform alpha","525",""
> "Q9D142-1","NP_001303653.1","uridine diphosphate glucose pyrophosphatase NUDT14 isoform 2","210",""
18758c18728,18731
< "Q3UWW6-1","NP_001271273.1","GAS2-like protein 3 isoform 2","368",""
---
> "Q8K558-1","NP_001276380.1","trem-like transcript 1 protein isoform 2 precursor","243",""
> "Q922Z0-1","NP_001303645.1","D-aspartate oxidase isoform 2 precursor","167",""
> "Q9QX96-1","NP_001231845.1","sal-like protein 2 isoform 2","1002",""
> "P09240-1","NP_001271437.1","cholecystokinin isoform 2 precursor","134","This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Homozygous knockout mice for this gene exhibit impaired insulin secretion, enhanced insulin sensitivity, and resistance to obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]. "
18760c18733,18734
< "O88735-1","NP_032661.2","ensconsin isoform 1","730",""
---
> "Q3UHH1-1","NP_001239010.1","zinc finger SWIM domain-containing protein 8 isoform 2","1825",""
> "Q8BFR6-1","NP_001317942.1","AN1-type zinc finger protein 1 isoform 2","207",""
18762,18765c18736,18739
< "Q3URY2-1","NP_001272847.1","geminin coiled-coil domain-containing protein 1 isoform 3","291",""
< "Q8BVD5-1","NP_001155092.1","MAGUK p55 subfamily member 7 isoform 2","427",""
< "Q9EQS9-1","NP_064427.2","immunoglobulin superfamily DCC subclass member 4 isoform 2 precursor","1252",""
< "Q8C0R7-1","NP_001335266.1","zinc finger MYND domain-containing protein 15 isoform 2","606",""
---
> "Q9EQZ7-1","NP_001243313.1","regulating synaptic membrane exocytosis protein 2 isoform d","285",""
> "Q8BPM0-1","NP_001273381.1","disheveled-associated activator of morphogenesis 1 isoform b","1068",""
> "Q8R3B1-1","NP_001280577.1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 1","782",""
> "Q6PE65-1","NP_001311417.1","G patch domain-containing protein 2-like isoform 2","408",""
18768,18769c18742,18744
< "Q2TUM3-1","NP_996857.1","potassium channel regulatory protein isoform 2","191",""
< "Q9Z1X4-1","NP_034691.2","interleukin enhancer-binding factor 3 isoform 1","911","The protein encoded by this gene contains two double-stranded RNA binding domains and functions in the post-transcriptional regulation of gene expression. It is a component of an RNA-protein complex that may be involved in mediating the export of messenger RNAs. Alternative splicing results in multiple transcript variants encoding distinct isoforms. These isoforms are grouped into two categories, NFAR-1 or NFAR-2, based on variation at the C-terminus. [provided by RefSeq, Mar 2013]. "
---
> "Q8VBX6-1","NP_001292213.1","multiple PDZ domain protein isoform 1","2069",""
> "Q9DAQ9-1","NP_001291987.1","spermatogenesis-associated protein 19, mitochondrial isoform 2","119",""
> "Q9CR22-1","NP_001158295.1","transmembrane protein 42 isoform 2","129",""
18771,18772c18746,18747
< "Q5XJY6-1","NP_778192.3","Fanconi anemia group B protein homolog isoform 2","706",""
< "Q3U6N9-1","NP_473440.1","UPF0488 protein C8orf33 homolog isoform 2","160",""
---
> "Q3UMU9-1","NP_001291713.1","hepatoma-derived growth factor-related protein 2 isoform 1","678",""
> "P47941-1","NP_001264160.1","crk-like protein isoform 2","108","This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In certain mouse genetic backgrounds this protein is essential for embryonic development. It is important for neural crest cell differentiation and survival and is proposed to play an important role in transducing the oncogenic signal of Bcr/Abl. Deletion of this gene in mouse mimics the phenotype of DiGeorge/velocardiofacial syndrome in human. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]. "
18775d18749
< "Q3U9N9-1","NP_082523.1","monocarboxylate transporter 10 isoform 2","320",""
18776a18751
> "Q60605-1","NP_001304147.1","myosin light polypeptide 6 isoform MLC3nm","151",""
18779,18781c18754
< "Q69ZN7-1","NP_001289069.1","myoferlin isoform 1","2061","The protein encoded by this gene is a member of the ferlin family of proteins, which have been implicated in fusion events in muscle tissue. Members of this family have a carboxy-terminal single pass transmembrane domain and multiple C2 domains, which bind negatively charged phospholipids in the presence of calcium ions. This gene is expressed at high levels in myoblasts and upregulated in damaged skeletal muscle. Mice deficient in this protein display defects in myoblast fusion, muscle regeneration, and angiogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. "
< "Q5K6N0-1","NP_001276415.1","transmembrane protein 232 isoform b","674",""
< "Q3UHD9-1","NP_001287943.1","arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform 2","1166","The protein encoded by this gene is a member of the centaurin GTPase family. This gene product regulates the activity of multiple kinases, including PI3K. Reduced expression of this gene results in multiple defects, including neural deficiencies, while increased expression of this gene has been observed in some tumors. Alternative splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]. "
---
> "Q99KW3-3","NP_001034244.1","TRIO and F-actin-binding protein isoform 4","980","This gene encodes a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility, and cell growth. The encoded protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in the human gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants have been described [provided by RefSeq, Sep 2012]. "
18782a18756
> "Q91WE9-1","NP_001239239.1","chemokine-like protein TAFA-5 isoform 1 precursor","132","This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]. "
18783a18758
> "Q9EPU4-1","NP_001157645.1","cleavage and polyadenylation specificity factor subunit 1 isoform 1","1450",""
18785c18760,18761
< "Q6NZN1-1","NP_001333730.1","peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 2","1646",""
---
> "Q3TVP5-1","NP_001229352.1","inactive ubiquitin thioesterase OTULINL isoform 1","353",""
> "P14152-1","NP_001303604.1","malate dehydrogenase, peroxisomal isoform Mdh1x","355","This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. A pseudogene has been identified on chromosomes 12. [provided by RefSeq, Feb 2016]. "
18786a18763
> "Q8CG46-1","NP_001239613.1","structural maintenance of chromosomes protein 5 isoform 1","1101",""
18789,18790c18766
< "O88576-1","NP_001162117.1","sodium-dependent neutral amino acid transporter B(0)AT3 isoform 6","605",""
< "P62849-1","NP_997518.1","40S ribosomal protein S24 isoform 3","131",""
---
> "Q6S5C2-1","NP_001333666.1","N-acetylglucosamine-1-phosphotransferase subunit gamma isoform 2 precursor","314",""
18791a18768
> "Q9ERA0-1","NP_001276532.1","alpha-globin transcription factor CP2 isoform 2","500",""
18794c18771
< "Q8R2U0-1","NP_082388.1","nucleoporin SEH1 isoform b","357",""
---
> "Q91WD0-1","NP_001295001.1","protein GPR108 isoform 2 precursor","562",""
18798,18801c18775,18779
< "Q8R4T9-1","NP_109608.1","urea transporter 2 isoform b","461",""
< "Q08AU7-1","NP_081027.1","myeloid-associated differentiation marker-like protein 2 isoform 1","307",""
< "P62881-1","NP_619733.1","guanine nucleotide-binding protein subunit beta-5 isoform 2","353",""
< "Q6AXC6-1","NP_001335221.1","ATP-dependent DNA helicase DDX11 isoform 2","906",""
---
> "Q8VDC0-1","NP_001335096.1","probable leucine--tRNA ligase, mitochondrial isoform 1","902",""
> "Q501J6-1","NP_001035277.1","probable ATP-dependent RNA helicase DDX17 isoform 4","650","This gene encodes the mouse homolog of human DEAD box polypeptide 17. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). RNA helicases of the DEAD-box family are involved in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. "
> "Q8R5G7-1","NP_001192265.1","arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 2","1460","This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
> "Q8BH79-1","NP_001258802.1","anoctamin-10 isoform 2","601","This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to inhibit anion conductance. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Dec 2012]. "
> "Q9CZP7-1","NP_001289309.1","hsp90 co-chaperone Cdc37-like 1 isoform 2","312","This gene encodes a protein related to the Hsp90 co-chaperone Cdc37. This protein may have a role in mediating interactions between the Hsp90 complex and other proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. "
18805c18783,18787
< "Q69ZA1-1","NP_081394.1","cyclin-dependent kinase 13 isoform 2","1451",""
---
> "P27040-1","NP_001300686.1","activin receptor type-2B isoform 2 precursor","512",""
> "Q9D2N4-1","NP_001272736.1","dystrobrevin alpha isoform a","746",""
> "Q78XR0-1","NP_001318110.1","trafficking protein particle complex subunit 6A isoform b","183",""
> "Q18PE0-1","NP_001335203.1","protein Dok-7 isoform 2","504",""
> "P98195-1","NP_001188498.1","probable phospholipid-transporting ATPase IIB isoform 1","1146",""
18807,18808c18789,18793
< "Q0GGX2-1","NP_001334488.1","zinc finger protein 541 isoform 1","1302",""
< "K9J7E2-1","NP_001160109.1","uncharacterized protein LOC100043224","289",""
---
> "Q6P9J9-1","NP_001240742.1","anoctamin-6 isoform 1","932",""
> "P55850-1","NP_001278738.1","desmocollin-3 isoform 2 precursor","839","This gene encodes a member of the cadherin family of proteins that mediates adhesion in desmosomes. Together with desmogleins, the encoded protein forms the transmembrane core of desmosomes, a multiprotein complex involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. Mice lacking the encoded protein exhibit a pre-implantation lethal phenotype. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2016]. "
> "O70293-1","NP_001033107.1","G protein-coupled receptor kinase 6 isoform a","589",""
> "Q5BU09-1","NP_001318091.1","E2F-associated phosphoprotein isoform 2","243",""
> "Q8C650-1","NP_001020081.2","septin-10 isoform 1","452",""
18811d18795
< "Q8BM14-1","NP_766425.1","lipase member K isoform 2 precursor","398",""
18813c18797,18808
< "Q8CH25-1","NP_080613.1","SAFB-like transcription modulator isoform b","1013",""
---
> "Q5RJG7-1","NP_001276431.1","D-ribitol-5-phosphate cytidylyltransferase isoform 2","397",""
> "P55264-1","NP_001229970.1","adenosine kinase isoform 2","345",""
> "Q80YR4-1","NP_001335160.1","E3 ubiquitin-protein ligase ZNF598 isoform 2","905",""
> "P34914-1","NP_001258332.1","bifunctional epoxide hydrolase 2 isoform c precursor","536",""
> "Q8VD62-2","NP_001243444.1","UPF0696 protein C11orf68 homolog isoform b","181",""
> "Q68FF0-1","NP_001334171.1","uncharacterized protein KIAA1841 isoform 2","572",""
> "O35298-1","NP_001268783.1","acyloxyacyl hydrolase isoform 2 preproprotein","145","This genes encodes an enzyme that catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides. The encoded protein modulates host inflammatory response to gram-negative bacteria. The proprotein is further cleaved into a large and small chain that interact in a heterodimer. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Aug 2013]. "
> "Q7TPG7-1","NP_001239316.1","chemokine-like protein TAFA-2 isoform 2 precursor","131","This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]. "
> "Q8C050-1","NP_001317631.1","ribosomal protein S6 kinase alpha-5 isoform 2","798",""
> "P03953-1","NP_001278844.1","complement factor D isoform 2 preproprotein","258","This gene encodes a serine protease that plays an important role in the alternative pathway of complement activation for pathogen recognition and elimination. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme that in turn cleaves factor B in the complement pathway. This gene is expressed in adipocytes and the mature enzyme is secreted into the bloodstream. Mice lacking the encoded product cannot initiate alternative pathway of complement activation. [provided by RefSeq, Jul 2016]. "
> "Q6PDQ2-1","NP_001333539.1","chromodomain-helicase-DNA-binding protein 4","1915",""
> "Q8BKX7-1","NP_001239511.1","zinc finger protein 410 isoform 2","347",""
18815c18810
< "Q4PNJ2-1","NP_001020457.2","sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 short isoform","196",""
---
> "Q8BY89-1","NP_001186115.1","choline transporter-like protein 2 isoform 1","704",""
18817,18819c18812,18813
< "Q8CC88-1","NP_776119.2","von Willebrand factor A domain-containing protein 8 isoform 2 precursor","1038",""
< "Q9D4I2-1","NP_083173.2","meiosis inhibitor protein 1 isoform 1","1268",""
< "Q9QX11-1","NP_035310.2","cytohesin-1 isoform 1","398",""
---
> "Q8BGE4-1","NP_001229348.1","sushi domain-containing protein 6 isoform 1","323",""
> "Q8VHN8-1","NP_001303644.1","tudor-interacting repair regulator protein isoform 2","151",""
18820a18815
> "P47931-1","NP_001288302.1","follistatin FST315 precursor","344","The protein encoded by this gene binds to and negatively regulates activin, as well as other members of the transforming growth factor beta family, and acts to prevent uncontrolled cellular proliferation. This protein also contains a heparin-binding sequence. It is expressed in many of the tissues in which activin is synthesized and is thought to clear activin from the circulation by attachment to the cell surface. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms, including FST315 and FST288, that differ at their C-terminus. Another isoform, FST303 is thought to be produced by proteolytic cleavage of FST315. These isoforms differ in their localization and in their ability to bind heparin. While FST315 is a circulating protein, FST288 is tissue-bound, and FST303 is gonad-specific. While deletion of all isoforms results in embryonic lethality, expression of just FST288 is sufficient for embryonic development, but the resultant mice have fertility defects. [provided by RefSeq, Aug 2014]. "
18823a18819
> "Q9DA69-1","NP_001186772.1","intraflagellar transport protein 43 homolog isoform 1","206",""
18826c18822,18826
< "Q8BP47-1","NP_081626.2","asparagine--tRNA ligase, cytoplasmic isoform 2","558",""
---
> "Q91ZE9-1","NP_001318150.1","bcl-2-modifying factor isoform 3","185",""
> "Q9D289-1","NP_001293146.1","trafficking protein particle complex subunit 6B isoform 2","121",""
> "Q60695-1","NP_001333046.1","ral guanine nucleotide dissociation stimulator-like 1 isoform 1","803","This gene encodes a member of the Ras-like (Ral) -selective guanine nucleotide exchange factor (RalGEF) family of small GTPase activators which function both as downstream effectors of activated Ras GTPase and as regulators of certain Ral GTPases in the RalGEF - Ral GTPase signaling pathway. The encoded protein, like other RalGEFs, has an N-terminal ras exchanger motif domain, a catalytic CDC25 homology domain, and a C-terminal ras binding domain that stimulates guanine nucleotide exchange when bound to a Ral GTPase. RalGEF family members bridge the Ras and Ral signaling pathways and are thought to play a role in oncogenic transformation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. "
> "Q8BRF7-1","NP_001293107.1","sec1 family domain-containing protein 1 isoform 2","390",""
> "Q9D1C8-1","NP_001292597.1","vacuolar protein sorting-associated protein 28 homolog isoform 2","183","This gene encodes a protein which is thought to be a subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]. "
18828c18828,18832
< "Q9JLN6-1","NP_899222.1","disintegrin and metalloproteinase domain-containing protein 28 isoform 2 precursor","768","This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are typically membrane-anchored, although a form of this protein may be secreted. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a mature protein product. This protein may bind to integrins and regulate lymphocyte migration by enhancing cell adhesion. [provided by RefSeq, Aug 2015]. "
---
> "Q6NXK8-1","NP_001276720.1","acid-sensing ion channel 1 isoform 2","559",""
> "Q3UPC7-1","NP_001074822.1","uncharacterized protein KIAA0825 homolog isoform 2","324",""
> "Q920S1-1","NP_001292737.1","granzyme N isoform 1 precursor","213",""
> "Q8BHN3-1","NP_001280550.1","neutral alpha-glucosidase AB isoform 2 precursor","944",""
> "K9J7E2-1","NP_001160108.1","uncharacterized protein LOC100043247","289",""
18836c18840
< "P17439-1","NP_032120.1","lysosomal acid glucosylceramidase precursor","515",""
---
> "P48356-1","NP_001116371.1","leptin receptor isoform 3 precursor","894",""
18843d18846
< "Q924M5-1","NP_083543.2","protein boule-like isoform 1","293",""
18846a18850
> "P17439-1","NP_001070879.1","lysosomal acid glucosylceramidase precursor","515",""
18852a18857
> "Q920M5-1","NP_624354.1","coronin-6 isoform A","471",""
18874a18880
> "Q924M5-1","NP_001106838.1","protein boule-like isoform 2","160",""
18884d18889
< "P48356-1","NP_666258.2","leptin receptor isoform 1 precursor","1162",""
18896d18900
< "Q920M5-1","NP_624356.1","coronin-6 isoform B","471",""
18898d18901
< "Q9WTK7-1","NP_035622.1","serine/threonine-protein kinase STK11 isoform L","436","This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]. "
18904c18907,18910
< "Q0QWG9-1","NP_579933.1","delphilin isoform 2","1024",""
---
> "Q9ES28-1","NP_001106989.1","rho guanine nucleotide exchange factor 7 isoform a","782",""
> "Q9Z0V1-1","NP_001034436.1","potassium voltage-gated channel subfamily D member 3 isoform 1 precursor","636",""
> "Q9QZB6-1","NP_001294918.1","nuclear receptor subfamily 4 group A member 3 isoform 2","429","This gene encodes a member of the NR4A subfamily of nuclear hormone receptors that bind to DNA and modulate gene expression. The encoded protein has been implicated in T and B lymphocyte apoptosis, and immune cell proliferation. Mice lacking the encoded protein exhibit partial bidirectional circling behavior and inner ear dysfunction. Disruption of this gene in mice also results in defective hippocampal axonal growth and postnatal neuronal cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. "
> "Q91ZU6-1","NP_034211.2","dystonin isoform 4","2639",""
18906c18912,18913
< "Q6ZWY9-1","NP_835503.1","histone H2B type 1-C/E/G","126","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]. "
---
> "Q9D9V3-1","NP_001103665.1","ethylmalonyl-CoA decarboxylase isoform b","299",""
> "Q8BRE0-1","NP_001171371.2","protein RD3 isoform 2","105",""
18909d18915
< "Q9D7V9-1","NP_080248.2","N-acylethanolamine-hydrolyzing acid amidase isoform 1 precursor","362",""
18912,18913c18918
< "Q8BRE0-1","NP_076216.3","protein RD3 isoform 1","195",""
< "Q9D9V3-1","NP_080131.4","ethylmalonyl-CoA decarboxylase isoform a","322",""
---
> "Q9D7V9-1","NP_001157159.1","N-acylethanolamine-hydrolyzing acid amidase isoform 2 precursor","360",""
18915a18921
> "Q6ZWY9-1","NP_001171124.1","histone H2B type 1-C/E/G","126","Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates multiple transcripts through alternative splicing, the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Aug 2015]. "
18917a18924
> "Q6PHU5-1","NP_001258528.1","sortilin isoform 1 precursor","858",""
18919c18926
< "Q8CHK4-1","NP_848752.1","histone acetyltransferase KAT5 isoform 1","513",""
---
> "Q5HZJ0-1","NP_001123621.1","ribonuclease 3","1373",""
18920a18928
> "Q9Z2E1-1","NP_001298000.1","methyl-CpG-binding domain protein 2 isoform 2","249",""
18924c18932,18933
< "Q641K1-1","NP_075817.2","cytosolic carboxypeptidase 1 isoform 1","1218",""
---
> "Q08857-1","NP_001153027.1","platelet glycoprotein 4","472",""
> "P09470-1","NP_033728.1","angiotensin-converting enzyme isoform 2 precursor","732",""
18926a18936
> "Q62120-1","NP_001041642.1","tyrosine-protein kinase JAK2","1132",""
18928a18939
> "Q04863-1","NP_001277386.1","transcription factor RelB isoform 2","555",""
18929a18941
> "Q8BLA8-1","NP_001335217.1","transient receptor potential cation channel subfamily A member 1 isoform 2","1095",""
18931a18944
> "Q60819-1","NP_001258426.1","interleukin-15 receptor subunit alpha isoform 2","123",""
18932a18946
> "Q6SJQ7-1","NP_001162624.1","CMRF35-like molecule 1 isoform 1 precursor","337",""
18933a18948
> "Q9Z2E9-1","NP_001129536.1","seipin isoform 1","443",""
18934a18950
> "Q8C0J2-1","NP_001192320.1","autophagy-related protein 16-1 isoform 1","623",""
18936c18952
< "Q9ESU6-1","NP_932762.2","bromodomain-containing protein 4 isoform 2","723","This gene was temporarily named bromodomain-containing 5 (Brd5) and was renamed bromodomain-containing 4 (Brd4). [provided by RefSeq, Jul 2008]. "
---
> "Q9ESU6-1","NP_065254.3","bromodomain-containing protein 4 isoform 1","1400","This gene was temporarily named bromodomain-containing 5 (Brd5) and was renamed bromodomain-containing 4 (Brd4). [provided by RefSeq, Jul 2008]. "
18938a18955
> "Q8CHK4-1","NP_001186176.1","histone acetyltransferase KAT5 isoform 2","461",""
18940c18957
< "P09813-1","NP_038502.2","apolipoprotein A-II preproprotein","102","This gene encodes a component of high density lipoproteins (HDL). Mice lacking the encoded protein have low HDL-cholesterol levels, smaller HDL particles, increased clearance of triglyceride-rich lipoproteins and insulin hypersensitivity. Transgenic mice overexpressing the encoded protein have elevated levels of HDL-cholesterol and show increased susceptibility to atherosclerosis. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015]. "
---
> "P21803-1","NP_034337.2","fibroblast growth factor receptor 2 isoform IIIc","840",""
18942,18944c18959,18960
< "Q9Z0V1-1","NP_064315.1","potassium voltage-gated channel subfamily D member 3 isoform 2 precursor","655",""
< "Q60841-1","NP_035391.2","reelin isoform 1 precursor","3461",""
< "P09056-1","NP_032527.1","leukemia inhibitory factor isoform a precursor","203",""
---
> "Q9Z0Y9-1","NP_001171201.1","oxysterols receptor LXR-alpha","445",""
> "O88839-1","NP_001032811.2","disintegrin and metalloproteinase domain-containing protein 15 isoform a preproprotein","864","This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is prominently expressed in vascular cells, the endocardium, hypertrophic cells in developing bone, and specific areas of hippocampus and cerebellum. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Mice lacking the encoded protein have increased bone mass resulting from osteoblast proliferation, and exhibit reduced neovascularization in a mouse model for retinopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing. [provided by RefSeq, May 2016]. "
18945a18962
> "P41593-1","NP_001077404.1","parathyroid hormone/parathyroid hormone-related peptide receptor precursor","591",""
18949,18950c18966
< "Q62261-1","NP_787030.2","spectrin beta chain, non-erythrocytic 1 isoform 1","2363",""
< "Q99MU3-1","NP_062629.3","double-stranded RNA-specific adenosine deaminase isoform 1","1152",""
---
> "Q09014-1","NP_001272966.1","neutrophil cytosol factor 1 isoform a","404",""
18951a18968
> "P79621-1","NP_001230690.1","MHC class II transactivator isoform 3","1075","This gene encodes a member of the NOD-like receptor protein family. This protein acts as a transcriptional coactivator and component of the enhanceosome complex to stimulate transcription of MHC class II genes in the adaptive immune response. This protein may also regulate the transcription of MHC class I genes. Mutations in the human gene have been linked to a rare immunodeficiency, bare lymphocyte syndrome, and homozygous knockout mice exhibit many features of this disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. "
18954d18970
< "Q9Z0Y9-1","NP_038867.2","oxysterols receptor LXR-alpha","445",""
18958d18973
< "Q6PHU5-1","NP_064356.2","sortilin isoform 2 precursor","825",""
18960,18962d18974
< "P09470-1","NP_997507.1","angiotensin-converting enzyme isoform 1 precursor","1312",""
< "Q91ZU6-1","NP_604443.2","dystonin isoform 2","7393",""
< "Q04863-1","NP_033072.2","transcription factor RelB isoform 1","558",""
18964a18977
> "Q30KP6-1","NP_001035116.1","beta-defensin 41 isoform 2 precursor","65",""
18965a18979
> "O08537-1","NP_034287.3","estrogen receptor beta isoform 2","549",""
18967d18980
< "Q80X41-1","NP_035835.1","serine/threonine-protein kinase VRK1 isoform a","440",""
18969d18981
< "Q08857-1","NP_031669.3","platelet glycoprotein 4","472",""
18970a18983
> "P21237-1","NP_001041604.1","brain-derived neurotrophic factor isoform 2 preproprotein","249","The protein encoded by this gene is a member of the nerve growth factor family. It is involved in the growth, differentiation and survival of specific types of developing neurons both in the central nervous system (CNS) and the peripheral nervous system. It is also involved in regulating synaptic plasticity in the CNS. Expression of a similar gene in human is reduced in both Alzheimer's and Huntington disease patients. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]. "
18972,18973d18984
< "P58307-1","NP_945197.2","orexin receptor type 1 isoform 1","416",""
< "Q8BLA8-1","NP_808449.1","transient receptor potential cation channel subfamily A member 1 isoform 1","1125",""
18975d18985
< "Q9Z2E1-1","NP_034903.2","methyl-CpG-binding domain protein 2 isoform 1","414",""
18980d18989
< "Q61462-1","NP_031832.2","cytochrome b-245 light chain isoform 1","192",""
18982c18991
< "Q9Z2E9-1","NP_032170.3","seipin isoform 1","443",""
---
> "Q641K1-1","NP_001041473.1","cytosolic carboxypeptidase 1 isoform 2","789",""
18989c18998
< "O08537-1","NP_997590.1","estrogen receptor beta isoform 1","567",""
---
> "Q80X41-1","NP_001025014.1","serine/threonine-protein kinase VRK1 isoform b","416",""
18993c19002
< "P41593-1","NP_035329.2","parathyroid hormone/parathyroid hormone-related peptide receptor precursor","591",""
---
> "P37238-1","NP_001120802.1","peroxisome proliferator-activated receptor gamma isoform 1","475","This gene encodes a nuclear receptor protein belonging to the peroxisome proliferator-activated receptor (Ppar) family. The encoded protein is a ligand-activated transcription factor that is involved in the regulation of adipocyte differentiation and glucose homeostasis. The encoded protein forms a heterodimer with retinoid X receptors and binds to DNA motifs termed 'peroxisome proliferator response elements' to either activate or inhibit gene expression. Mice lacking the encoded protein die at an embryonic stage due to severe defects in placental vascularization. When the embryos lacking this gene are supplemented with healthy placentas, the mutants survive to term, but succumb to lipodystrophy and multiple hemorrhages. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. "
18995d19003
< "O08707-1","NP_067622.2","atypical chemokine receptor 2","378",""
18996a19005
> "Q9WUG6-1","NP_001277577.1","insulin-like peptide INSL5 isoform 1 precursor","145",""
18999a19009
> "O08707-1","NP_001263648.1","atypical chemokine receptor 2","378",""
19003d19012
< "Q8C0J2-1","NP_084122.2","autophagy-related protein 16-1 isoform 2","607",""
19009,19010c19018
< "P37238-1","NP_035276.2","peroxisome proliferator-activated receptor gamma isoform 2","505","This gene encodes a nuclear receptor protein belonging to the peroxisome proliferator-activated receptor (Ppar) family. The encoded protein is a ligand-activated transcription factor that is involved in the regulation of adipocyte differentiation and glucose homeostasis. The encoded protein forms a heterodimer with retinoid X receptors and binds to DNA motifs termed 'peroxisome proliferator response elements' to either activate or inhibit gene expression. Mice lacking the encoded protein die at an embryonic stage due to severe defects in placental vascularization. When the embryos lacking this gene are supplemented with healthy placentas, the mutants survive to term, but succumb to lipodystrophy and multiple hemorrhages. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. "
< "O88839-1","NP_033744.1","disintegrin and metalloproteinase domain-containing protein 15 isoform b precursor","815","This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is prominently expressed in vascular cells, the endocardium, hypertrophic cells in developing bone, and specific areas of hippocampus and cerebellum. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Mice lacking the encoded protein have increased bone mass resulting from osteoblast proliferation, and exhibit reduced neovascularization in a mouse model for retinopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing. [provided by RefSeq, May 2016]. "
---
> "P01139-1","NP_001106168.1","beta-nerve growth factor isoform B precursor","241",""
19012,19013d19019
< "P21237-1","NP_001303239.1","brain-derived neurotrophic factor isoform 2 preproprotein","249","The protein encoded by this gene is a member of the nerve growth factor family. It is involved in the growth, differentiation and survival of specific types of developing neurons both in the central nervous system (CNS) and the peripheral nervous system. It is also involved in regulating synaptic plasticity in the CNS. Expression of a similar gene in human is reduced in both Alzheimer's and Huntington disease patients. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]. "
< "Q60819-1","NP_598597.1","interleukin-15 receptor subunit alpha isoform 2","123",""
19015d19020
< "Q5HZJ0-1","NP_081075.3","ribonuclease 3","1373",""
19018d19022
< "Q62120-1","NP_032439.2","tyrosine-protein kinase JAK2","1132",""
19023c19027,19028
< "P01139-1","NP_038637.1","beta-nerve growth factor isoform A","307",""
---
> "P58307-1","NP_001156499.1","orexin receptor type 1 isoform 1","416",""
> "Q99MU3-1","NP_001139768.1","double-stranded RNA-specific adenosine deaminase isoform 3","1178",""
19025c19030,19031
< "Q6SJQ7-1","NP_663609.2","CMRF35-like molecule 1 isoform 2 precursor","330",""
---
> "Q62261-1","NP_033286.2","spectrin beta chain, non-erythrocytic 1 isoform 2","2154",""
> "Q9WTK7-1","NP_001288782.1","serine/threonine-protein kinase STK11 isoform S","412","This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]. "
19031a19038,19039
> "Q61462-1","NP_001288213.1","cytochrome b-245 light chain isoform 2","164",""
> "P09813-1","NP_001292478.1","apolipoprotein A-II preproprotein","102","This gene encodes a component of high density lipoproteins (HDL). Mice lacking the encoded protein have low HDL-cholesterol levels, smaller HDL particles, increased clearance of triglyceride-rich lipoproteins and insulin hypersensitivity. Transgenic mice overexpressing the encoded protein have elevated levels of HDL-cholesterol and show increased susceptibility to atherosclerosis. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015]. "
19037c19045
< "P21803-1","NP_963895.2","fibroblast growth factor receptor 2 isoform IIIb","726",""
---
> "P09056-1","NP_001034626.1","leukemia inhibitory factor isoform b","158",""
19040c19048,19049
< "Q09014-1","NP_035006.3","neutrophil cytosol factor 1 isoform b","390",""
---
> "Q0QWG9-1","NP_001152793.1","delphilin isoform 1","1203",""
> "P97477-1","NP_001278114.1","aurora kinase A isoform b","395",""
19043d19051
< "Q8BZ32-1","NP_766009.2","putative Polycomb group protein ASXL2 isoform 2","1370","This gene encodes a homolog of the Drosophila Asx gene, which interacts with genes involved in axial patterning. Mice with mutations in this gene display abnormal patterning of the axial skeleton, suggesting a similar function in mice as in Drosophila. This gene may also be involved in bone mineral density, specifically osteoclastogenesis. [provided by RefSeq, Aug 2012]. "
19045c19053
< "Q9WTZ1-1","NP_035409.1","RING-box protein 2 isoform 1","113",""
---
> "P29477-1","NP_001300850.1","nitric oxide synthase, inducible isoform b","1031","Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase that is inducible by a combination of lipopolysaccharide and certain cytokines. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
19046a19055
> "P28776-1","NP_001280619.1","indoleamine 2,3-dioxygenase 1 isoform 2","316",""
19047a19057
> "P35329-1","NP_001036782.1","B-cell receptor CD22 precursor","868",""
19048a19059
> "Q80Z64-1","NP_001276757.1","homeobox protein NANOG isoform 2","304","The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
19057d19067
< "P39688-1","NP_032080.2","tyrosine-protein kinase Fyn isoform b","534",""
19058a19069
> "Q8BG51-1","NP_001156826.1","mitochondrial Rho GTPase 1 isoform 2","663",""
19065d19075
< "P23804-1","NP_034916.1","E3 ubiquitin-protein ligase Mdm2 isoform 1","489",""
19067d19076
< "P97772-1","NP_058672.1","metabotropic glutamate receptor 1 isoform alpha precursor","1199",""
19072a19082
> "P20181-1","NP_001157506.1","neurotrophin-3 isoform a","271","This gene encodes a member of the neurotrophins that have a wide variety of functions in both neural and non-neural tissues. The encoded preproprotein undergoes proteolytic processing to generate a noncovalently linked homodimeric mature protein that can bind to the transmembrane receptor tyrosine kinases to initiate a series of signaling events. Mice lacking the encoded protein exhibit severe defects in the peripheral nervous system including a complete lack of spinal proprioceptive afferents and their peripheral sense organs. [provided by RefSeq, Sep 2016]. "
19074d19083
< "P47811-1","NP_036081.1","mitogen-activated protein kinase 14 isoform 1","360",""
19077,19078d19085
< "Q9QYG0-1","NP_038892.1","protein NDRG2 isoform 1","371",""
< "Q08501-1","NP_035299.4","prolactin receptor isoform 1 precursor","608",""
19079a19087
> "P51450-1","NP_001280663.1","nuclear receptor ROR-gamma isoform 2","495",""
19081,19082c19089
< "P70284-1","NP_033398.2","homeobox protein TGIF1 isoform b","272",""
< "P37242-1","NP_033406.1","thyroid hormone receptor beta isoform 2","475",""
---
> "Q8C078-1","NP_001186605.1","calcium/calmodulin-dependent protein kinase kinase 2 isoform 1","588",""
19084c19091,19093
< "P56818-1","NP_035922.4","beta-secretase 1 isoform 1 preproprotein","501","This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. Homozygous knockout mice for this gene exhibit a wide range of nervous system defects, growth retardation, metabolic abnormalities, and increased neonatal lethality. [provided by RefSeq, Nov 2015]. "
---
> "P12660-1","NP_001123276.1","Purkinje cell protein 2 isoform 2","120",""
> "A3KGV1-1","NP_001106684.1","outer dense fiber protein 2 isoform a","825",""
> "Q02780-1","NP_001116424.1","nuclear factor 1 A-type isoform 1","532",""
19086c19095
< "Q9R0H0-1","NP_056544.2","peroxisomal acyl-coenzyme A oxidase 1 isoform 1","661","This gene encodes a member of the acyl-coenzyme A oxidase family. The encoded protein is localized to peroxisomes and is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-coenzyme A to 2-trans-enoyl-coenzyme A. Disruption of this gene results in microvesicular steatohepatitis, spontaneous peroxisome proliferation, and the eventual development of hepatocellular carcinomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]. "
---
> "P23708-1","NP_001334330.1","nuclear transcription factor Y subunit alpha isoform c","346",""
19088d19096
< "Q9ES28-1","NP_059098.2","rho guanine nucleotide exchange factor 7 isoform c","646",""
19090d19097
< "Q9Z0L0-1","NP_035757.2","trophoblast glycoprotein precursor","426",""
19091a19099,19100
> "Q3ULA2-1","NP_001032847.2","F-box/WD repeat-containing protein 1A isoform a","605",""
> "Q921F2-1","NP_001003899.1","TAR DNA-binding protein 43 isoform 3","295",""
19094,19099c19103,19105
< "O54918-1","NP_997564.1","bcl-2-like protein 11 isoform 2","140",""
< "P12660-1","NP_032816.1","Purkinje cell protein 2 isoform 3","99",""
< "P97477-1","NP_035627.1","aurora kinase A isoform a","417",""
< "Q3ULA2-1","NP_033901.1","F-box/WD repeat-containing protein 1A isoform b","569",""
< "Q8R1R4-1","NP_083922.1","interleukin-34 isoform 2 precursor","219",""
< "P33587-1","NP_001300867.1","vitamin K-dependent protein C isoform 2 preproprotein","460","This gene encodes the vitamin K-dependent protein C, which plays a vital role in the anticoagulation pathway. The encoded protein undergoes proteolytic processing including activation by thrombin-thrombomodulin complex to form the anticoagulant serine protease that degrades activated coagulation factors. A complete lack of the encoded protein in mice results in severe perinatal consumptive coagulopathy in the brain and liver, resulting in death within 24 hours after birth. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2015]. "
---
> "Q9JL99-1","NP_001191168.1","C-type lectin domain family 1 member B isoform 2","197",""
> "Q61701-1","NP_001033787.1","ELAV-like protein 4 isoform b","380",""
> "Q8R1R4-1","NP_001128572.1","interleukin-34 isoform 1 precursor","235",""
19103d19108
< "P29477-1","NP_035057.1","nitric oxide synthase, inducible isoform a","1144","Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase that is inducible by a combination of lipopolysaccharide and certain cytokines. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
19108a19114,19115
> "Q61097-1","NP_001335136.1","kinase suppressor of Ras 1 isoform 2","818",""
> "Q9Z0M5-1","NP_001104570.1","lysosomal acid lipase/cholesteryl ester hydrolase precursor","397",""
19110d19116
< "P97875-1","NP_112149.2","jun dimerization protein 2","163",""
19111a19118,19119
> "O09044-1","NP_001171263.1","synaptosomal-associated protein 23 isoform a","221",""
> "Q9R0H0-1","NP_001258827.1","peroxisomal acyl-coenzyme A oxidase 1 isoform 2","661","This gene encodes a member of the acyl-coenzyme A oxidase family. The encoded protein is localized to peroxisomes and is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-coenzyme A to 2-trans-enoyl-coenzyme A. Disruption of this gene results in microvesicular steatohepatitis, spontaneous peroxisome proliferation, and the eventual development of hepatocellular carcinomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]. "
19113d19120
< "Q8C078-1","NP_663333.1","calcium/calmodulin-dependent protein kinase kinase 2 isoform 2","541",""
19118c19125
< "Q60604-1","NP_033158.2","adseverin isoform 2","615",""
---
> "Q8QZS3-1","NP_001258285.1","folliculin","579",""
19119a19127
> "Q60612-1","NP_001008533.1","adenosine receptor A1 isoform a","326",""
19121d19128
< "Q9Z2S7-1","NP_034416.3","TSC22 domain family protein 3 isoform 2","137",""
19124d19130
< "Q61701-1","NP_001334107.1","ELAV-like protein 4 isoform e","366",""
19126d19131
< "P35329-1","NP_033975.3","B-cell receptor CD22 precursor","868",""
19133d19137
< "Q62417-1","NP_001030136.1","sorbin and SH3 domain-containing protein 1 isoform 5","740",""
19136,19138c19140,19142
< "O70325-1","NP_032188.3","phospholipid hydroperoxide glutathione peroxidase isoform A precursor","197","The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Disruption of this gene in mouse spermatocytes is associated with male infertility. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Transcript variants resulting from alternative splicing or use of alternate promoters have been described to encode isoforms with different subcellular localization. Pseudogenes of this locus have been identified on chromosomes 10 and 17. [provided by RefSeq, Jan 2019]. "
< "Q02780-1","NP_035035.1","nuclear factor 1 A-type isoform 2","509",""
< "P70399-1","NP_038763.3","TP53-binding protein 1 isoform a","1969",""
---
> "P97772-1","NP_001107805.1","metabotropic glutamate receptor 1 isoform beta precursor","906",""
> "Q9ET54-1","NP_001074859.1","palladin isoform 4","1113",""
> "O70325-1","NP_001032830.2","phospholipid hydroperoxide glutathione peroxidase isoform B","253","The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Disruption of this gene in mouse spermatocytes is associated with male infertility. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Transcript variants resulting from alternative splicing or use of alternate promoters have been described to encode isoforms with different subcellular localization. Pseudogenes of this locus have been identified on chromosomes 10 and 17. [provided by RefSeq, Jan 2019]. "
19140c19144
< "P23708-1","NP_035043.1","nuclear transcription factor Y subunit alpha isoform b","318",""
---
> "Q3UWA6-1","NP_001120790.1","heat-stable enterotoxin receptor isoform 1 precursor","1072",""
19142,19143c19146
< "Q64685-1","NP_666045.1","beta-galactoside alpha-2,6-sialyltransferase 1","403","This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on chromosome 15. [provided by RefSeq, Nov 2011]. "
< "P30993-1","NP_031603.2","C5a anaphylatoxin chemotactic receptor 1","351",""
---
> "Q8BZ32-1","NP_001257917.1","putative Polycomb group protein ASXL2 isoform 1","1418","This gene encodes a homolog of the Drosophila Asx gene, which interacts with genes involved in axial patterning. Mice with mutations in this gene display abnormal patterning of the axial skeleton, suggesting a similar function in mice as in Drosophila. This gene may also be involved in bone mineral density, specifically osteoclastogenesis. [provided by RefSeq, Aug 2012]. "
19147,19148d19149
< "Q61097-1","NP_038599.1","kinase suppressor of Ras 1 isoform 1","873",""
< "Q3UWA6-1","NP_659504.2","heat-stable enterotoxin receptor isoform 2 precursor","1048",""
19150d19150
< "P21107-1","NP_001280677.2","tropomyosin alpha-3 chain isoform Tpm3.12st","285",""
19154,19157c19154,19157
< "Q8BG51-1","NP_067511.4","mitochondrial Rho GTPase 1 isoform 1","631",""
< "Q9ET54-1","NP_001280703.1","palladin isoform 3","663",""
< "P14824-1","NP_038500.2","annexin A6 isoform a","673",""
< "P24161-1","NP_112439.1","CD247 antigen isoform eta precursor","206",""
---
> "P97875-1","NP_001191981.1","jun dimerization protein 2","163",""
> "Q9QYB2-1","NP_001033699.1","dachshund homolog 1 isoform 2","699",""
> "P39688-1","NP_001116364.1","tyrosine-protein kinase Fyn isoform b","534",""
> "O54918-1","NP_033884.1","bcl-2-like protein 11 isoform 3","110",""
19159c19159
< "O09044-1","NP_033248.1","synaptosomal-associated protein 23 isoform b","210",""
---
> "P47811-1","NP_001161980.1","mitogen-activated protein kinase 14 isoform 2","360",""
19161c19161,19162
< "Q8VDQ8-1","NP_071877.3","NAD-dependent protein deacetylase sirtuin-2 isoform 1","389",""
---
> "Q64685-1","NP_001239434.1","beta-galactoside alpha-2,6-sialyltransferase 1","403","This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on chromosome 15. [provided by RefSeq, Nov 2011]. "
> "P30993-1","NP_001167021.1","C5a anaphylatoxin chemotactic receptor 1","351",""
19164,19166c19165
< "P51450-1","NP_035411.2","nuclear receptor ROR-gamma isoform 1","516",""
< "Q8QZS3-1","NP_666130.1","folliculin","579",""
< "P31310-1","NP_032289.2","homeobox protein Hox-A10 isoform a","416","In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of a cluster on chromosome 6 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. "
---
> "Q9Z2S7-1","NP_001070832.1","TSC22 domain family protein 3 isoform 1","201",""
19169,19170c19168
< "Q921F2-1","NP_663531.1","TAR DNA-binding protein 43 isoform 1","414",""
< "Q61411-1","NP_032310.2","GTPase HRas isoform 1","189",""
---
> "P70399-1","NP_001277759.1","TP53-binding protein 1 isoform b","1919",""
19184a19183,19184
> "P21107-1","NP_001240667.1","tropomyosin alpha-3 chain isoform Tpm3.1cy","248",""
> "P31725-1","NP_001268781.1","protein S100-A9","113",""
19187,19188d19186
< "Q80Z64-1","NP_082292.1","homeobox protein NANOG isoform 1","305","The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. "
< "Q9JL99-1","NP_064369.1","C-type lectin domain family 1 member B isoform 1","229",""
19190c19188
< "Q9QYB2-1","NP_031852.1","dachshund homolog 1 isoform 1","751",""
---
> "Q9QYG0-1","NP_001139431.1","protein NDRG2 isoform 2","357",""
19195a19194
> "Q9Z0L0-1","NP_001158264.1","trophoblast glycoprotein precursor","426",""
19199a19199
> "Q9WTZ1-1","NP_001298064.1","RING-box protein 2 isoform 2","90",""
19202a19203
> "O35350-1","NP_001103974.1","calpain-1 catalytic subunit","713",""
19205a19207,19209
> "Q61411-1","NP_001123915.1","GTPase HRas isoform 1","189",""
> "Q8VDQ8-1","NP_001116237.1","NAD-dependent protein deacetylase sirtuin-2 isoform 2","352",""
> "P33587-1","NP_001036232.1","vitamin K-dependent protein C isoform 2 preproprotein","460","This gene encodes the vitamin K-dependent protein C, which plays a vital role in the anticoagulation pathway. The encoded protein undergoes proteolytic processing including activation by thrombin-thrombomodulin complex to form the anticoagulant serine protease that degrades activated coagulation factors. A complete lack of the encoded protein in mice results in severe perinatal consumptive coagulopathy in the brain and liver, resulting in death within 24 hours after birth. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2015]. "
19206a19211,19212
> "Q62417-1","NP_001030134.1","sorbin and SH3 domain-containing protein 1 isoform 3","714",""
> "Q08501-1","NP_001240711.1","prolactin receptor isoform 3 precursor","303",""
19207a19214
> "P31310-1","NP_001116422.1","homeobox protein Hox-A10 isoform b","94","In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of a cluster on chromosome 6 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. "
19210,19212d19216
< "A3KGV1-1","NP_038643.1","outer dense fiber protein 2 isoform c","638",""
< "P28776-1","NP_032350.1","indoleamine 2,3-dioxygenase 1 isoform 1","407",""
< "P08226-1","NP_033826.2","apolipoprotein E precursor","311","This gene encodes a member of the apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Homozygous knockout mice for this gene accumulate high levels of cholesterol in the blood and develop atherosclerosis. Different alleles of this gene have been associated with either increased risk or a protective effect for Alzheimer's disease in human patients. This gene maps to chromosome 7 in a cluster with the related apolipoprotein C1, C2 and C4 genes. [provided by RefSeq, Apr 2015]. "
19214a19219,19220
> "Q9Z319-1","NP_001116228.1","atrial natriuretic peptide-converting enzyme isoform 2","1047",""
> "P24161-1","NP_001106862.1","CD247 antigen isoform zeta precursor","164",""
19215a19222,19223
> "P70284-1","NP_001157546.1","homeobox protein TGIF1 isoform c","252",""
> "P23804-1","NP_001275515.1","E3 ubiquitin-protein ligase Mdm2 isoform 2","440",""
19217d19224
< "Q60612-1","NP_001278857.1","adenosine receptor A1 isoform b","236",""
19220c19227,19228
< "P20181-1","NP_032768.1","neurotrophin-3 isoform b preproprotein","258","This gene encodes a member of the neurotrophins that have a wide variety of functions in both neural and non-neural tissues. The encoded preproprotein undergoes proteolytic processing to generate a noncovalently linked homodimeric mature protein that can bind to the transmembrane receptor tyrosine kinases to initiate a series of signaling events. Mice lacking the encoded protein exhibit severe defects in the peripheral nervous system including a complete lack of spinal proprioceptive afferents and their peripheral sense organs. [provided by RefSeq, Sep 2016]. "
---
> "P14824-1","NP_001103681.1","annexin A6 isoform b","667",""
> "P56818-1","NP_001139419.1","beta-secretase 1 isoform 2 precursor","467","This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. Homozygous knockout mice for this gene exhibit a wide range of nervous system defects, growth retardation, metabolic abnormalities, and increased neonatal lethality. [provided by RefSeq, Nov 2015]. "
19221a19230,19231
> "Q60604-1","NP_001139668.1","adseverin isoform 1","715",""
> "P08226-1","NP_001292748.1","apolipoprotein E precursor","311","This gene encodes a member of the apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Homozygous knockout mice for this gene accumulate high levels of cholesterol in the blood and develop atherosclerosis. Different alleles of this gene have been associated with either increased risk or a protective effect for Alzheimer's disease in human patients. This gene maps to chromosome 7 in a cluster with the related apolipoprotein C1, C2 and C4 genes. [provided by RefSeq, Apr 2015]. "
19223d19232
< "Q9Z0M5-1","NP_067435.3","lysosomal acid lipase/cholesteryl ester hydrolase precursor","397",""
19226c19235,19236
< "Q8VBV4-2","NP_001171245.1","F-box/WD repeat-containing protein 7 isoform 1","710",""
---
> "Q9WU72-1","NP_001334238.1","tumor necrosis factor ligand superfamily member 13B isoform 2","290",""
> "Q8VBV4-2","NP_536353.2","F-box/WD repeat-containing protein 7 isoform 2","629",""
19228a19239
> "P37242-1","NP_001106888.1","thyroid hormone receptor beta isoform 1","461",""
19230d19240
< "Q9WU72-1","NP_296371.1","tumor necrosis factor ligand superfamily member 13B isoform 1","309",""
19234d19243
< "Q9Z319-1","NP_058565.2","atrial natriuretic peptide-converting enzyme isoform 1","1113",""
19236d19244
< "P31725-1","NP_033140.1","protein S100-A9","113",""
19240d19247
< "O35350-1","NP_031626.1","calpain-1 catalytic subunit","713",""