{
    "bcoid": "GLY_000134",
    "title": "Mouse Protein Function (NCBI Refseq)",
    "description": "The Mouse Protein Function (NCBI RefSeq) dataset contains biological function annotaion of mouse [taxid:10090] ...",
    "filename": "mouse_protein_function_refseq.csv",
    "filetype": "csv",
    "categories": {
        "species": "Mus Musculus",
        "molecule": "Protein",
        "tags": "Protein Function",
        "file_type": "csv",
        "status": "Reviewed",
        "scope": "internal"
    },
    "minitable": {
        "content": [
            [
                "Q61718-1...",
                "RefSeq..."
            ],
            [
                "Q61718-1...",
                "RefSeq..."
            ]
        ],
        "headers": [
            "uniprotkb_ca...",
            "database_nam..."
        ],
        "colwidth": [
            "40%",
            "20%"
        ]
    },
    "sampledata": {
        "type": "table",
        "data": [
            [
                {
                    "type": "string",
                    "label": "uniprotkb_canonical_ac"
                },
                {
                    "type": "string",
                    "label": "database_name"
                },
                {
                    "type": "string",
                    "label": "database_id"
                },
                {
                    "type": "string",
                    "label": "evidence"
                },
                {
                    "type": "string",
                    "label": "annotation"
                }
            ],
            [
                "Q61718-1",
                "RefSeq",
                "NP_996753.1",
                "21172865",
                "A distinct subset of plasmacytoid dendritic cells (pDC) is responsible for nearly all IFN-alpha production, while in bone marrow and spleen, cells that ultimately differentiate into pDC produce little or no IFN-alpha and instead promote immune tolerance."
            ],
            [
                "Q61718-1",
                "RefSeq",
                "NP_996753.1",
                "16611902",
                "Results suggest that activation of the Ras/Raf/MEK pathway downregulates IFN-induced antiviral response"
            ],
            [
                "Q80YF9-1",
                "RefSeq",
                "NP_839983.1",
                "26839058",
                "ARHGAP33 interacts with SORT1 to cooperatively regulate TrkB trafficking. ARHGAP33 KO mice exhibit reduced expression of synaptic TrkB, impaired dendritic spine development and neuropsychiatric disorder-related behavioural abnormalities. Erratum:[Nat Commun. 2016;7:11466. PMID: 27095349] Publication Status: Online-Only"
            ],
            [
                "Q80YF9-1",
                "RefSeq",
                "NP_839983.1",
                "24003235",
                "Results indicate that SNX26 interacts with PSD-95 and regulates formation of dendritic spines."
            ],
            [
                "Q80YF9-1",
                "RefSeq",
                "NP_839983.1",
                "22810622",
                "Cofilin activation during late cortical development depended on NOMA-GAP expression and subsequent inhibition of Cdc42. In utero expression of active cofilin was sufficient to restore postnatal dendritic complexity in NOMA-GAP-deficient animals."
            ],
            [
                "Q80YF9-1",
                "RefSeq",
                "NP_839983.1",
                "12773384",
                "Overexpression of the full-length and C-terminal fragments of TCGAP inhibits insulin-stimulated glucose uptake and GLUT4 translocation."
            ],
            [
                "Q5F2L2-1",
                "RefSeq",
                "NP_598922.1",
                "23986452",
                "Fut10 is involved in a unique alpha1,3-fucosyltransferase activity with stringent substrate specificity."
            ],
            [
                "Q8VBV4-2",
                "RefSeq",
                "NP_001171245.1",
                "31278268",
                "Study finds that loss of Fbxw7 enhances the myelinating potential of Schwann cells (SCs). Fbxw7 mutant SCs make thicker myelin sheaths and sometimes appear to myelinate multiple axons in a fashion reminiscent of oligodendrocytes. Taken together, findings show that the restriction of myelinating SCs to myelinate a single axon may be mutable and that Fbxw7 is a critical player in regulating the myelinating potential of SCs. Publication Status: Online-Only"
            ],
            [
                "Q8VBV4-2",
                "RefSeq",
                "NP_001171245.1",
                "29633504",
                "Loss of FBXW7 promotes non-small-cell lung cancer progression as well as gefitinib resistance."
            ],
            [
                "Q8VBV4-2",
                "RefSeq",
                "NP_001171245.1",
                "29475832",
                "FBXW7 is markedly downregulated in the liver of obese mice. Mechanistically, FBXW7 directly binds to hepatokine fetuin-A to induce its ubiquitination and subsequent proteasomal degradation, comprising an important mechanism maintaining glucose homeostasis."
            ],
            [
                "Q8VBV4-2",
                "RefSeq",
                "NP_001171245.1",
                "29550488",
                "Found that Fbw7 loss caused activation of NF-kappaB signaling. Thus, FBW7 plays a protective role in acute intestinal inflammation by modulating the inflammatory response of NF-kappaB pathway."
            ],
            [
                "Q9JMG3-1",
                "RefSeq",
                "NP_071863.1",
                "24240191",
                "HOPS has distinct, isoform-specific functions in the nucleolus, nucleus, and cytoplasm."
            ],
            [
                "Q9JMG3-1",
                "RefSeq",
                "NP_071863.1",
                "22890319",
                "HOPS acts as a functional bridge in the interaction between NPM and p19(Arf)"
            ],
            [
                "Q9JMG3-1",
                "RefSeq",
                "NP_071863.1",
                "20582322",
                "Results implicate Tmub1 in the regulation of locomotor activity and wakefulness and suggest that Tmub1 binds to and functions together with CAMLG Publication Status: Online-Only"
            ],
            [
                "Q9JMG3-1",
                "RefSeq",
                "NP_071863.1",
                "18665261",
                "Transmission; it contributes to maintain the synaptic surface number of the GluR2-containing AMPARs by facilitating the recycling of GluR2 to the plasma membrane Publication Status: Online-Only"
            ],
            [
                "Q9JMG3-1",
                "RefSeq",
                "NP_071863.1",
                "18418082",
                "HOPS is involved in centrosome assembly and maintenance."
            ],
            [
                "Q9DCN2-1",
                "RefSeq",
                "NP_084063.1",
                "29706024",
                "Results highlight the importance of CYB5R3 and NQO1, two NAD(+) producers, for the promotion of health and extended lifespan"
            ],
            [
                "Q9DCN2-1",
                "RefSeq",
                "NP_084063.1",
                "20927338",
                "Amino and carboxy terminal fragments of mDia1 form a tetrameric complex composed of two interlocking N+C dimers. Publication Status: Online-Only"
            ],
            [
                "Q9DCN2-1",
                "RefSeq",
                "NP_084063.1",
                "20566685",
                "Nucleation is achieved by a mechanism involving APC-B dimerization and recruitment of multiple actin monomers. Further, APC-B nucleation activity is synergistic with its in vivo binding partner, the formin mDia1"
            ],
            [
                "P25916-1",
                "RefSeq",
                "NP_031578.2",
                "30209188",
                "This study shows that Bmi1 regulates IkappaBalpha degradation via association with the SCF complex"
            ],
            [
                "Q60972-1",
                "RefSeq",
                "NP_033056.2",
                "30026490",
                "ARMC12 promotes neuroblastoma progression through interaction with RBBP4. Publication Status: Online-Only"
            ],
            [
                "Q60972-1",
                "RefSeq",
                "NP_033056.2",
                "25788661",
                "RBBP4 is a regulator of histone deacetylation during oocyte maturation and deacetylation is required for bipolar spindle assembly through Aurora kinase C"
            ],
            [
                "Q60972-1",
                "RefSeq",
                "NP_033056.2",
                "26376479",
                "RbAp48 was identified as critical in the proliferation of hypopharyngeal carcinoma in both in vitro and in vivo experiments."
            ],
            [
                "Q9JHF7-1",
                "RefSeq",
                "NP_062328.3",
                "30161143",
                "Validation of differentially expressed genes (DEGs) by quantitative RT-PCR showed a significant increase in PLA2 group 4c (Pla2g4c)/COX-2 (Ptgs2)/PGD2 synthase 2 (Hpgds) axis. PGD2 level in bronchoalveolar fluids of the OA-challenged mice was significantly increased. A 24-h incubation of BSM tissues with PGD2 caused a hyperresponsiveness to acetylcholine in naive control mice. Publication Status: Online-Only"
            ],
            [
                "Q9JHF7-1",
                "RefSeq",
                "NP_062328.3",
                "26159556",
                "H-PGDS deficiency accelerates the production of SDF-1alpha and the activity of MMP-9 in the antigen-stimulated intestine. SDF-1alpha receptor blockade or MMP-9 inhibition relieves the exacerbated mast cell hyperplasia and manifestations observed in H-PGDS(-/-). Publication Status: Online-Only"
            ],
            [
                "Q9JHF7-1",
                "RefSeq",
                "NP_062328.3",
                "16547141",
                "HPGD(2)S-derived cyclopentenone prostaglandins may protect against inflammatory diseases, where T lymphocytes play a pathogenic role, as in rheumatoid arthritis, atopic eczema, and chronic rejection"
            ],
            [
                "Q9DAX9-1",
                "RefSeq",
                "NP_080101.1",
                "18780968",
                "Amyloid beta precursor protein gene is associated with Alzheimer's disease"
            ],
            [
                "Q08652-1",
                "RefSeq",
                "NP_033060.3",
                "28970247",
                "Study demonstrates that Piasy may prevent exaggerated transcription of IFNI by Rbp2-mediated demethylation of H3K4me3 of IFNI, avoiding excessive immune responses"
            ],
            [
                "Q08652-1",
                "RefSeq",
                "NP_033060.3",
                "28874522",
                "Genetic deletion of RBP1 and RBP2 did not impair synapse ultrastructure of ribbon-type synapses formed between rod bipolar cells (RBCs) and amacrine type-2 (AII) cells in the mouse retina but dramatically reduced the density of presynaptic Ca(2+) channels, decreased and desynchronized evoked neurotransmitter release"
            ],
            [
                "Q08652-1",
                "RefSeq",
                "NP_033060.3",
                "27537484",
                "RBPs perform unexpectedly broad roles at the active zone that together with those of RIMs are essential for all active zone functions."
            ],
            [
                "Q08652-1",
                "RefSeq",
                "NP_033060.3",
                "25255718",
                "The present study was designed to detect the expression of Histone H3 lysine 4 methylation and its demethylases LSD1, RBP2 and SMCX in 21-, 40- and 60-day-old mouse testes."
            ],
            [
                "Q8K5B8-1",
                "RefSeq",
                "NP_034593.1",
                "27977683",
                "We find a subtle impact of deleting the Hotair locus upon the expression of the neighboring Hoxc11 and Hoxc12 genes in cis. Our results do not support any substantial role for Hotair during mammalian development in vivo Publication Status: Online-Only"
            ],
            [
                "Q8K4Z0-1",
                "RefSeq",
                "NP_659194.1",
                "19833108",
                "LGI2 distribution in the vertical limb of the diagonal band and in putative hippocampal interneurons suggests that the function of these genes might be related to the generation of hippocampal theta rhythm."
            ],
            [
                "Q6GYP7-1",
                "RefSeq",
                "NP_064378.4",
                "12200424",
                "Interacts with transcription factor E12 in developing forebrain"
            ],
            [
                "P56481-1",
                "RefSeq",
                "NP_031653.1",
                "27448962",
                "Our data suggest a progression model for BE to EAC in which CCK2R+ progenitor cells, stimulated by hypergastrinemia, proliferate to give rise to metaplasia and dysplasia."
            ],
            [
                "P56481-1",
                "RefSeq",
                "NP_031653.1",
                "26751218",
                "CCKBR and D5R synergistically interact in the kidney, which may contribute to the maintenance of normal sodium balance following an increase in sodium intake Publication Status: Online-Only"
            ],
            [
                "P56481-1",
                "RefSeq",
                "NP_031653.1",
                "25875176",
                "There is functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development. Publication Status: Online-Only"
            ],
            [
                "O88845-1",
                "RefSeq",
                "NP_064305.2",
                "17485678",
                "These studies suggest a role for AKAP10 in heart rhythm control."
            ],
            [
                "O88845-1",
                "RefSeq",
                "NP_064305.2",
                "14531807",
                "D-AKAP2 may play an important role in the parathyroid hormone (PTH)-mediated regulation of NaPi-IIa by compartmentalization of PKA."
            ],
            [
                "O88845-1",
                "RefSeq",
                "NP_064305.2",
                "12206784",
                "Deuterium exchange-mass spectrometry (DXMS) and limited proteolysis to probe the folded regions of D-AKAP2, providing for the first time insight into the intra-domain dynamics of a scaffold protein"
            ],
            [
                "Q8BXR6-1",
                "RefSeq",
                "NP_766423.3",
                "26310831",
                "Pellino-3 is involved in endotoxin tolerance and functions as a negative regulator of Toll-like receptor 2/4 signaling."
            ],
            [
                "Q8BXR6-1",
                "RefSeq",
                "NP_766423.3",
                "25483963",
                "Autophagy causes PELI3 degradation during TLR4-signaling, thereby impairing the hyperinflammatory phase during sepsis by inhibiting proinflammatory IL1B expression"
            ],
            [
                "Q8BXR6-1",
                "RefSeq",
                "NP_766423.3",
                "23892723",
                "Our findings identify RIP2 as a substrate for Pellino3 and Pellino3 as an important mediator in the Nod2 pathway and regulator of intestinal inflammation."
            ],
            [
                "Q8BXR6-1",
                "RefSeq",
                "NP_766423.3",
                "24113711",
                "Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-alpha."
            ],
            [
                "Q8BXR6-1",
                "RefSeq",
                "NP_766423.3",
                "23042151",
                "Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons."
            ],
            [
                "Q8BHN5-1",
                "RefSeq",
                "NP_700454.1",
                "18782777",
                "ARC may protect cardiomyocytes from hypoxic cell death by regulating its downstream, Drbp1 and pMe(2)GlyDH"
            ],
            [
                "Q9DAU7-1",
                "RefSeq",
                "NP_080599.1",
                "21807117",
                "Causal testing implicates Wfdc2 and Hdac3 as novel genes affecting high density lipoprotein levels"
            ],
            [
                "Q9CQA3-1",
                "RefSeq",
                "NP_075863.2",
                "30159755",
                "The present study identified a potential role for the tumor microenvironment in influencing phenotypic features of SDHB-mutated Pheochromocytomas and paragangliomas."
            ],
            [
                "Q8BHW5-1",
                "RefSeq",
                "NP_766518.3",
                "17660561",
                "Transcripts highly enriched in ovary; gene identified as candidate female fertility factor."
            ],
            [
                "Q08890-1",
                "RefSeq",
                "NP_034628.2",
                "29648648",
                "We also show that mucopolysaccharidosis type II patient fibroblasts harboring different mutations spanning the IDS gene exhibit perturbed FGF signaling-related markers expression. Our work opens a new venue to discover possible druggable novel key targets in mucopolysaccharidosis type II Erratum:[Hum Mol Genet. 2018 Jul 1;27(13):2407. PMID: 29917101]"
            ],
            [
                "Q3UFT3-1",
                "RefSeq",
                "NP_001028617.2",
                "24003223",
                "Data indicate that a subtype of GAREM, GAREM2, is specifically expressed in the mouse, rat, and human brain."
            ],
            [
                "Q5EE38-1",
                "RefSeq",
                "NP_001335278.1",
                "30189268",
                "Analyses demonstrate that the majority of differentially expressed genes in acd mutant embryos are due to p53-dependent mechanisms and reflect the observed phenotypic differences between acd mutant and double mutant embryos."
            ],
            [
                "Q5EE38-1",
                "RefSeq",
                "NP_001335278.1",
                "29386102",
                "Show that TPP1 NOB is critical for telomerase function and demonstrate that the telomerase interaction surface on TPP1 is more elaborate than previously appreciated"
            ],
            [
                "Q5EE38-1",
                "RefSeq",
                "NP_001335278.1",
                "24469404",
                "Shelterin protein TIN2 can protect chromosome ends as a TRF2-tethered TIN2/TPP1/POT1 complex that lacks a physical connection to TRF1"
            ],
            [
                "Q5EE38-1",
                "RefSeq",
                "NP_001335278.1",
                "24316971",
                "Mouse hematopoietic stem cells are acutely sensitive to inactivation of the shelterin gene Acd."
            ],
            [
                "Q5EE38-1",
                "RefSeq",
                "NP_001335278.1",
                "17632522",
                "Tpp1 is required for the protective function of Pot1 proteins. Erratum:[Nat Struct Mol Biol. 2009 May;16(5):572]"
            ],
            [
                "Q5EE38-1",
                "RefSeq",
                "NP_001335278.1",
                "15537664",
                "Telomeric regulator is required for proper urogenital ridge differentiation, axial skeleton specification and limb patterning in mice."
            ],
            [
                "Q00420-1",
                "RefSeq",
                "NP_997552.1",
                "25200183",
                "SIRT7 stabilizes and activates the GABP alpha/GABPbeta complex via deacetylation of GABPbeta1."
            ],
            [
                "Q00420-1",
                "RefSeq",
                "NP_997552.1",
                "22862946",
                "The findings identify the tetramer-forming GABPbeta1 as specific HSC regulators and potential therapeutic targets in treating LSC-based hematological malignancy."
            ],
            [
                "Q00420-1",
                "RefSeq",
                "NP_997552.1",
                "21944889",
                "After antigenic stimulation CD4+/CD62Lhigh cells from Peyer's patches express a greater amount of transcripts of GA-binding protein beta subunit 1 than those from the spleen."
            ],
            [
                "Q8CIT9-1",
                "RefSeq",
                "NP_001077372.1",
                "25283635",
                "Findings suggest that SBSN is involved in the angiogenic potential of tumor endothelial cells (TEC) and may be a novel TEC marker."
            ],
            [
                "Q8CIT9-1",
                "RefSeq",
                "NP_001077372.1",
                "17330888",
                "Sbsn, Dmkn and Krtdap are coordinately expressed during epidermal morphogenesis."
            ],
            [
                "Q8CIT9-1",
                "RefSeq",
                "NP_001077372.1",
                "12228223",
                "These results indicate that the suprabasin protein potentially plays a role in the process of epidermal differentiation. GeneRIF: These results indicate that the suprabasin protein potentially plays a role in the process of epidermal differentiation"
            ],
            [
                "Q8BVZ5-1",
                "RefSeq",
                "NP_598536.2",
                "31227713",
                "Study of tumor-adjacent submucosal mast cell accumulation in murine and human intestinal-type gastric cancer revealed that mast cells are activated by IL-33 produced by the tumor epithelium in response to the inflammatory cytokine IL-11. Ablation of the cognate IL-33 receptor St2 limits tumor growth and reduces mast cell-dependent production and release of the macrophage-attracting factors Csf2, Ccl3, and Il6. Publication Status: Online-Only"
            ],
            [
                "Q8BVZ5-1",
                "RefSeq",
                "NP_598536.2",
                "31221971",
                "Study identified IL-33 as an immune target upregulated in response to hypervirulent C. difficile and demonstrated that IL-33 prevents C. difficile-associated mortality and epithelial disruption independently of bacterial burden or toxin expression. IL-33 drives colonic group 2 innate lymphoid cell (ILC2) activation during infection and IL-33 activated ILC2s are sufficient to prevent disease. Publication Status: Online-Only"
            ],
            [
                "Q8BVZ5-1",
                "RefSeq",
                "NP_598536.2",
                "30872761",
                "These observations show that IL-1 and IL-33 exert opposing functions in controlling the functional adaptation of Treg cells, ultimately dictating the dynamics of adaptive immunity to pathogens"
            ],
            [
                "Q8BVZ5-1",
                "RefSeq",
                "NP_598536.2",
                "17185418",
                "IL-33 is a dual function protein that may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties."
            ],
            [
                "Q8BVZ5-1",
                "RefSeq",
                "NP_598536.2",
                "16286016",
                "IL-33, which mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T(H)2 cells"
            ],
            [
                "Q8BFT9-1",
                "RefSeq",
                "NP_081081.1",
                "19013223",
                "These results indicate that msvop is a central nervous system-specific gene and could be utilized for elucidating gene regulation in neuronal cells."
            ],
            [
                "Q571F8-1",
                "RefSeq",
                "NP_001028436.2",
                "29274472",
                "Data (including data from studies in knockout/transgenic mice) suggest Ppp2ca supports cortical neuronal growth and cognitive function via regulating p73/Gls2 signal transduction in neurons of hippocampus. Ppp2ca gene knock-out results in embryonic cortical atrophy with learning/memory deficits. (Ppp2ca = protein phosphatase 2a catalytic subunit alpha isoform; p73 = transformation related protein 73; Gls2 = glutaminase-2)"
            ],
            [
                "Q571F8-1",
                "RefSeq",
                "NP_001028436.2",
                "27466601",
                "Gls2 expression is regulated by the dietary protein/carbohydrate ratio. This effect was not observed in Ppara-null mice."
            ],
            [
                "Q571F8-1",
                "RefSeq",
                "NP_001028436.2",
                "22679499",
                "Study demonstrated expression of alternative transcripts of the mammalian Gls2 gene. Transcriptional mechanisms giving rise to GLS2 variants and isolation of novel GLS2 transcripts in human, rat and mouse are presented."
            ],
            [
                "Q571F8-1",
                "RefSeq",
                "NP_001028436.2",
                "20351271",
                "Phosphate-activated glutaminase (GLS2) is a p53-inducible regulator of glutamine metabolism and reactive oxygen species"
            ],
            [
                "Q9DCD6-1",
                "RefSeq",
                "NP_062723.1",
                "28604719",
                "Cells that lacked GABARAPs and mice that lacked Gate-16 alone were defective in the IFN-gamma-induced clearance of vacuolar pathogens such as Toxoplasma. GABARAPs are uniquely required for antimicrobial host defense through cytosolic distribution of interferon-inducible GTPases."
            ],
            [
                "Q9DCD6-1",
                "RefSeq",
                "NP_062723.1",
                "28497576",
                "GABAergic synapse is proposed as a focus of aging. (Review) Review article"
            ],
            [
                "Q9DCD6-1",
                "RefSeq",
                "NP_062723.1",
                "28320742",
                "Development of LC3/GABARAP sensors containing a LIR and a hydrophobic domain to monitor autophagy."
            ],
            [
                "Q9DCD6-1",
                "RefSeq",
                "NP_062723.1",
                "27124579",
                "Ablation of GABARAP inhibits tumor initiation and progression through enhancement of both antitumor immunity and cell death signaling. Publication Status: Online-Only"
            ],
            [
                "P53811-1",
                "RefSeq",
                "NP_062614.1",
                "30042096",
                "These data show that ablating PITPs in MKs indirectly dysregulates hematopoiesis in the BM by disrupting alpha-granule physiology and secretion of TGF-beta1."
            ],
            [
                "P53811-1",
                "RefSeq",
                "NP_062614.1",
                "17683809",
                "Mouse NIH3T3 fibroblast cells overexpressing phosphatidylinositol transfer protein beta (PI-TPbeta, SPIbeta cells) demonstrate a low rate of proliferation and a high sensitivity towards UV-induced apoptosis when compared with wtNIH3T3 cells."
            ],
            [
                "P53811-1",
                "RefSeq",
                "NP_062614.1",
                "15164762",
                "Investigation of whether a relationship exists between PI-TPbeta being involved in maintaining plasma membrane sphingomyelin levels and the enhanced sensitivity towards apoptosis"
            ],
            [
                "P53811-1",
                "RefSeq",
                "NP_062614.1",
                "15052341",
                "The PITPbeta deficiency results in catastrophic failure early in murine embryonic development, and the PITPbeta is an essential housekeeping PIPT in murine cells. Review article"
            ],
            [
                "P53811-1",
                "RefSeq",
                "NP_062614.1",
                "11953429",
                "The Golgi localization of phosphatidylinositol transfer protein beta requires the protein kinase C-dependent phosphorylation of serine"
            ],
            [
                "P53811-1",
                "RefSeq",
                "NP_062614.1",
                "11907258",
                "Data suggest that phosphatidylinositol transfer protein (PITP) beta is an essential housekeeping PITP in murine cells, whereas PITP alpha plays a far more specialized function in mammals."
            ],
            [
                "Q8C9X1-1",
                "RefSeq",
                "NP_808292.1",
                "18829862",
                "Data suggest that sentan is the first molecular component of the ciliary tip to bridge the cell membrane and peripheral singlet microtubules, making the distal portion of the cilia narrow and stiff to allow for better airway clearance or ovum transport."
            ]
        ]
    },
    "readme": "Name\n   - Mouse Protein Function (NCBI Refseq)\n\nVersion\n   - 1.5.12\n\nCreated on\n  - 2019-03-16T15:38:06.344586\n\nModified on\n   - 2019-11-27T15:34:09.163629\n\nCreated by\n   - Jeet Vora [jeetvora@gwu.edu], Rahi Navelkar [rsn13@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Xavier Holmes [xavierh@email.gwu.edu]\n\nAuthors\n   - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n   - \n\nUsability Domain\n   - The Mouse Protein Function (NCBI RefSeq) dataset contains biological function annotaion of mouse [taxid:10090] genes from GeneRIF section in the NCBI RefSeq database. The dataset is derived from NCBI RefSeq Release 96, September 9, 2019. If you use this dataset please provide proper attribution to NCBI RefSeq and GlyGen\n\nDescription Domain\n   Keywords\n   - protein function\n   - NCBI RefSeq\n   - geneRIF\n   - PMID\n\n   Pipeline Steps\n   - Step-1: The script extract-from-gp.py extracts protein function information from NCBI RefSeq gpff format files and maps it to the UniProtKb canonical accessions for a final dataset output in a csv format\n\nExecution Domain\n   Scripts   - https://github.com/glygener/glygen-backend-integration/blob/master/pipeline/extractor/extract-from-endpoint.py\n\n\n   Software Prerequisites\n      Name: Python\n      Version: 2.7.5\n      URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n   Input Subdomain\n      Name: mouse_protein_xref_refseq.csv\n      URI: https://data.glygen.org/ln2wwwdata/reviewed/mouse_protein_xref_refseq.csv\n      Name: efseq_protein_all_10090.gpff\n      URI: https://data.glygen.org/ln2wwwdata/source/refseq_protein_all_10090.gpff\n   Output Subdomain\n      Name: mouse_protein_function_refseq.csv\n      URI: http://data.glygen.org/ln2wwwdata/reviewed/mouse_protein_function_refseq.csv\n      Name: mouse_protein_function_refseq.stat.csv\n      URI: http://data.glygen.org/ln2wwwdata/reviewed/mouse_protein_function_refseq.stat.csv\n\nFields\n      Name: \"database_id\"\n     Description: \"Identifier in the database\"\n      Unique Values: \"10877\"\n      Name: \"uniprotkb_canonical_ac\"\n     Description: \"Accession assigned to the protein isoform chosen to be the canonical sequence to which all positional annotation refers in UniProtKB database\"\n      Unique Values: \"10877\"\n      Name: \"database_name\"\n     Description: \"The name of the source database\"\n      Unique Values: \"1\"\n      Name: \"annotation\"\n     Description: \"Function annotation from UniProtKB|RefSeq database\"\n      Unique Values: \"27262\"\n      Name: \"evidence\"\n     Description: \"NCBI PubMed Id (PMID) as evidence for the entry/annotation\"\n      Unique Values: \"26623\"",
    "downloadurl": "/ln2data/releases/data/v-1.5.12/reviewed/mouse_protein_function_refseq.csv"
}
