4c4,12
< "A0A0B4J1F4-1","RefSeq","NP_001036057.1","19605364","Txnip regulates cellular metabolism independent of its binding to thioredoxin and the arrestin domains are crucial structural elements in metabolic functions of alpha-arrestin proteins"
---
> "Q80YF9-1","RefSeq","NP_839983.1","26839058","ARHGAP33 interacts with SORT1 to cooperatively regulate TrkB trafficking. ARHGAP33 KO mice exhibit reduced expression of synaptic TrkB, impaired dendritic spine development and neuropsychiatric disorder-related behavioural abnormalities. Erratum:[Nat Commun. 2016;7:11466. PMID: 27095349] Publication Status: Online-Only"
> "Q80YF9-1","RefSeq","NP_839983.1","24003235","Results indicate that SNX26 interacts with PSD-95 and regulates formation of dendritic spines."
> "Q80YF9-1","RefSeq","NP_839983.1","22810622","Cofilin activation during late cortical development depended on NOMA-GAP expression and subsequent inhibition of Cdc42. In utero expression of active cofilin was sufficient to restore postnatal dendritic complexity in NOMA-GAP-deficient animals."
> "Q80YF9-1","RefSeq","NP_839983.1","12773384","Overexpression of the full-length and C-terminal fragments of TCGAP inhibits insulin-stimulated glucose uptake and GLUT4 translocation."
> "Q5F2L2-1","RefSeq","NP_598922.1","23986452","Fut10 is involved in a unique alpha1,3-fucosyltransferase activity with stringent substrate specificity."
> "Q8VBV4-2","RefSeq","NP_001171245.1","31278268","Study finds that loss of Fbxw7 enhances the myelinating potential of Schwann cells (SCs). Fbxw7 mutant SCs make thicker myelin sheaths and sometimes appear to myelinate multiple axons in a fashion reminiscent of oligodendrocytes. Taken together, findings show that the restriction of myelinating SCs to myelinate a single axon may be mutable and that Fbxw7 is a critical player in regulating the myelinating potential of SCs. Publication Status: Online-Only"
> "Q8VBV4-2","RefSeq","NP_001171245.1","29633504","Loss of FBXW7 promotes non-small-cell lung cancer progression as well as gefitinib resistance."
> "Q8VBV4-2","RefSeq","NP_001171245.1","29475832","FBXW7 is markedly downregulated in the liver of obese mice. Mechanistically, FBXW7 directly binds to hepatokine fetuin-A to induce its ubiquitination and subsequent proteasomal degradation, comprising an important mechanism maintaining glucose homeostasis."
> "Q8VBV4-2","RefSeq","NP_001171245.1","29550488","Found that Fbw7 loss caused activation of NF-kappaB signaling. Thus, FBW7 plays a protective role in acute intestinal inflammation by modulating the inflammatory response of NF-kappaB pathway."
12a21
> "P25916-1","RefSeq","NP_031578.2","30209188","This study shows that Bmi1 regulates IkappaBalpha degradation via association with the SCF complex"
25a35
> "Q6GYP7-1","RefSeq","NP_064378.4","12200424","Interacts with transcription factor E12 in developing forebrain"
31a42,46
> "Q8BXR6-1","RefSeq","NP_766423.3","26310831","Pellino-3 is involved in endotoxin tolerance and functions as a negative regulator of Toll-like receptor 2/4 signaling."
> "Q8BXR6-1","RefSeq","NP_766423.3","25483963","Autophagy causes PELI3 degradation during TLR4-signaling, thereby impairing the hyperinflammatory phase during sepsis by inhibiting proinflammatory IL1B expression"
> "Q8BXR6-1","RefSeq","NP_766423.3","23892723","Our findings identify RIP2 as a substrate for Pellino3 and Pellino3 as an important mediator in the Nod2 pathway and regulator of intestinal inflammation."
> "Q8BXR6-1","RefSeq","NP_766423.3","24113711","Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-alpha."
> "Q8BXR6-1","RefSeq","NP_766423.3","23042151","Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons."
33d47
< "Q8BSN9-1","RefSeq","NP_001317352.1","20869947","These results introduce FASTKD3 as an essential component of mitochondrial respiration that may modulate energy balance in cells exposed to adverse conditions by functionally coupling mitochondrial protein synthesis to respiration."
38a53,61
> "Q5EE38-1","RefSeq","NP_001335278.1","30189268","Analyses demonstrate that the majority of differentially expressed genes in acd mutant embryos are due to p53-dependent mechanisms and reflect the observed phenotypic differences between acd mutant and double mutant embryos."
> "Q5EE38-1","RefSeq","NP_001335278.1","29386102","Show that TPP1 NOB is critical for telomerase function and demonstrate that the telomerase interaction surface on TPP1 is more elaborate than previously appreciated"
> "Q5EE38-1","RefSeq","NP_001335278.1","24469404","Shelterin protein TIN2 can protect chromosome ends as a TRF2-tethered TIN2/TPP1/POT1 complex that lacks a physical connection to TRF1"
> "Q5EE38-1","RefSeq","NP_001335278.1","24316971","Mouse hematopoietic stem cells are acutely sensitive to inactivation of the shelterin gene Acd."
> "Q5EE38-1","RefSeq","NP_001335278.1","17632522","Tpp1 is required for the protective function of Pot1 proteins. Erratum:[Nat Struct Mol Biol. 2009 May;16(5):572]"
> "Q5EE38-1","RefSeq","NP_001335278.1","15537664","Telomeric regulator is required for proper urogenital ridge differentiation, axial skeleton specification and limb patterning in mice."
> "Q00420-1","RefSeq","NP_997552.1","25200183","SIRT7 stabilizes and activates the GABP alpha/GABPbeta complex via deacetylation of GABPbeta1."
> "Q00420-1","RefSeq","NP_997552.1","22862946","The findings identify the tetramer-forming GABPbeta1 as specific HSC regulators and potential therapeutic targets in treating LSC-based hematological malignancy."
> "Q00420-1","RefSeq","NP_997552.1","21944889","After antigenic stimulation CD4+/CD62Lhigh cells from Peyer's patches express a greater amount of transcripts of GA-binding protein beta subunit 1 than those from the spleen."
41a65,69
> "Q8BVZ5-1","RefSeq","NP_598536.2","31227713","Study of tumor-adjacent submucosal mast cell accumulation in murine and human intestinal-type gastric cancer revealed that mast cells are activated by IL-33 produced by the tumor epithelium in response to the inflammatory cytokine IL-11. Ablation of the cognate IL-33 receptor St2 limits tumor growth and reduces mast cell-dependent production and release of the macrophage-attracting factors Csf2, Ccl3, and Il6. Publication Status: Online-Only"
> "Q8BVZ5-1","RefSeq","NP_598536.2","31221971","Study identified IL-33 as an immune target upregulated in response to hypervirulent C. difficile and demonstrated that IL-33 prevents C. difficile-associated mortality and epithelial disruption independently of bacterial burden or toxin expression. IL-33 drives colonic group 2 innate lymphoid cell (ILC2) activation during infection and IL-33 activated ILC2s are sufficient to prevent disease. Publication Status: Online-Only"
> "Q8BVZ5-1","RefSeq","NP_598536.2","30872761","These observations show that IL-1 and IL-33 exert opposing functions in controlling the functional adaptation of Treg cells, ultimately dictating the dynamics of adaptive immunity to pathogens"
> "Q8BVZ5-1","RefSeq","NP_598536.2","17185418","IL-33 is a dual function protein that may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties."
> "Q8BVZ5-1","RefSeq","NP_598536.2","16286016","IL-33, which mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T(H)2 cells"
50a79,84
> "P53811-1","RefSeq","NP_062614.1","30042096","These data show that ablating PITPs in MKs indirectly dysregulates hematopoiesis in the BM by disrupting alpha-granule physiology and secretion of TGF-beta1."
> "P53811-1","RefSeq","NP_062614.1","17683809","Mouse NIH3T3 fibroblast cells overexpressing phosphatidylinositol transfer protein beta (PI-TPbeta, SPIbeta cells) demonstrate a low rate of proliferation and a high sensitivity towards UV-induced apoptosis when compared with wtNIH3T3 cells."
> "P53811-1","RefSeq","NP_062614.1","15164762","Investigation of whether a relationship exists between PI-TPbeta being involved in maintaining plasma membrane sphingomyelin levels and the enhanced sensitivity towards apoptosis"
> "P53811-1","RefSeq","NP_062614.1","15052341","The PITPbeta deficiency results in catastrophic failure early in murine embryonic development, and the PITPbeta is an essential housekeeping PIPT in murine cells. Review article"
> "P53811-1","RefSeq","NP_062614.1","11953429","The Golgi localization of phosphatidylinositol transfer protein beta requires the protein kinase C-dependent phosphorylation of serine"
> "P53811-1","RefSeq","NP_062614.1","11907258","Data suggest that phosphatidylinositol transfer protein (PITP) beta is an essential housekeeping PITP in murine cells, whereas PITP alpha plays a far more specialized function in mammals."
59a94,95
> "Q8QZS5-1","RefSeq","NP_705724.1","30413537","These results indicate that (i) RNF183 is predominantly expressed in the normal renal medulla, (ii) NFAT5 stimulates transcriptional activation of Rnf183 by binding to its cognate binding motif in the Rnf183 promoter, and (iii) RNF183 protects renal medullary cells from hypertonicity-induced apoptosis."
> "Q8QZS5-1","RefSeq","NP_705724.1","26818663","RNF183, which is negatively regulated by miR-7, is a novel regulator promoting intestinal inflammation by increasing the ubiquitination and degradation of IkappaBalpha, thereby inducing NF-kappaB activation. The interaction between RNF183-mediated ubiquitination and miRNA may be an important novel epigenetic mechanism in the pathogenesis of inflammatory bowel disease."
71a108,109
> "Q8C2S0-1","RefSeq","NP_001193780.1","23187126","USP44 inhibited chromosome segregation errors independent of its role in the mitotic checkpoint by regulating centrosome separation, positioning, and mitotic spindle geometry."
> "Q8C2S0-1","RefSeq","NP_001193780.1","21853124","These data are consistent with an important role for USP44 in regulating Cdc20-APC/C activity and suggest that high levels of this enzyme may contribute to the pathogenesis of T-cell leukemias."
80a119,121
> "P53702-1","RefSeq","NP_032248.3","11668396","Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice"
> "E9Q1M1-1","RefSeq","NP_001074533.1","19932150","Results provide the first evidence that Pdzd2 is required for normal regulation of basal insulin secretion."
> "E9Q1M1-1","RefSeq","NP_001074533.1","19607921","These findings reveal that Pdzd2 and p11 play collaborative roles in regulation of Na(V)1.8 expression in sensory neurons."
95,98d135
< "Q8K3W0-2","RefSeq","NP_653124.1","28436570","Bre enhances osteoblastic differentiation by promoting the Mdm2-mediated degradation of p53."
< "Q8K3W0-2","RefSeq","NP_653124.1","27001068","Results demonstrate a role for BRE in both replicative senescence and DNA damage-induced premature senescence. This can be attributed to BRE being required for BRCA1-A complex-driven HR DNA repair Publication Status: Online-Only"
< "Q8K3W0-2","RefSeq","NP_653124.1","24395041","Depletion of BRE also increased tumor cell apoptosis, and decreased both local and metastatic tumor growth."
< "Q8K3W0-2","RefSeq","NP_653124.1","14565866","A highly conserved gene in two species can generate alternative transcripts different in both of the sequence structure and expression pattern, as well as a similar class of transcripts resulting from unconventional transcript processing."
104,107c141,146
< "Q91V88-1","RefSeq","NP_001025007.1","28842827","Low Nephronectin expression is associated with Metastatic Breast Carcinoma."
< "Q91V88-1","RefSeq","NP_001025007.1","29335243","Nephronectin is produced by podocytes and deposited into the GBM. It colocalized with alpha8beta1 integrin to novel, specialized adhesion structures at sites of mesangial cell protrusion at the base of the capillary loops. Nephronectin loss disrupted these structures, mislocalizating alpha8beta1, and caused mesangial sclerosis."
< "Q91V88-1","RefSeq","NP_001025007.1","28345658","Results show that Npnt is highly expressed in tooth germ, and localized in the basement membrane between dental epithelium and mesenchyme. The study indicates that Npnt plays a critical scaffold role in dental epithelial stem cell differentiation and proliferation, and regulates Sox2 expression during tooth development. Publication Status: Online-Only"
< "Q91V88-1","RefSeq","NP_001025007.1","17537792","Results thus place nephronectin and alpha8beta1 integrin in a pathway that regulates Gdnf expression and is essential for kidney development"
---
> "Q6P1G2-1","RefSeq","NP_038938.1","29166607","Tthat bone morphogenetic protein (BMP) represses Oct4/Kdm2b-induced somatic reprogramming selectively"
> "Q6P1G2-1","RefSeq","NP_038938.1","28319097","This study shows that long noncoding RNA Kdm2b expression sustains the maintenance of Innate lymphoid cells by promoting their proliferation through activation of the transcription factor Zfp292"
> "Q6P1G2-1","RefSeq","NP_038938.1","24856970","Genetic ablation in embryonic stem cells reveal that deletion of PRC1 has genome-wide effects on PRC2 occupancy and H3K27me3; recognition of nonmethylated DNA by KDM2B, part of the PCGF1/PRC1 variant complex, is important for deposition of H2AK119ub1 and recruitment of PRC2 to a subset of CpG island targets and that this activity is essential for normal mouse development."
> "Q6P1G2-1","RefSeq","NP_038938.1","21220025","Results suggest that the Fbxl10 gene makes important contributions to embryonic neural development by regulating cell proliferation and cell death in mice."
> "Q6P1G2-1","RefSeq","NP_038938.1","18836456","Results indicate that Jhdm1b is an H3K36 demethylase that regulates cell proliferation and senescence through p15(Ink4b)."
> "Q6P1G2-1","RefSeq","NP_038938.1","17296600","Study using a high throughput proteomics approach identified interactors with Rnf2 including Fbxl10/Jhdm1B, casein kinase subunits, and the BcoR corepressor"
112a152,159
> "Q8K1E6-1","RefSeq","NP_081220.1","26930515","These results revealed that N3-ethylthymidine , but not other DNA lesions, could be repaired by Alkbh2 and Alkbh3 in mammalian cells."
> "Q8K1E6-1","RefSeq","NP_081220.1","22684101","ALKBH2 and ALKBH3 provide cancer protection similar to that of the DNA glycosylase AAG and display apparent epistasis with Aag"
> "Q8R3I9-1","RefSeq","NP_666296.1","18826941","Up-regulation of beta3Gn-T8 in differentiated cells increases poly-N-acetyllactosamine chains by activating intrinsic beta3Gn-T2."
> "P59114-1","RefSeq","NP_666241.1","20811152","In adult mouse beta cells, Pcif1 limits Pdx1 protein accumulation and thus the expression of insulin and other gene targets important in the maintenance of beta cell mass and function."
> "Q9D708-1","RefSeq","NP_080692.1","23526364","S100A16 inhibits osteogenesis but stimulates adipogenesis by increasing the transcription of PPARgamma and decreasing the transcription of RUNX2."
> "Q9D708-1","RefSeq","NP_080692.1","21871643","High-calcium diets may lead to nuclear exclusion of S100A16, which results in the inhibition of adipogenesis and enhanced insulin sensitivity."
> "Q9D708-1","RefSeq","NP_080692.1","21266506","This study showed that S100A16 protein is a novel adipogenesis-promoting factor and that increased expression of S100A16 in 3T3-L1 adipocytes can have a negative impact on insulin sensitivity."
> "Q9D708-1","RefSeq","NP_080692.1","17030513","In situ hybridization analysis and immunohistochemistry revealed a widespread distribution in the mouse brain. Furthermore, S100A16 expression was found to be astrocyte-specific"
113a161,163
> "Q61481-4","RefSeq","NP_058024.2","28750036","These results support an important role of PDE1A in the renal pathogenesis of autosomal dominant polycystic kidney disease and in the regulation of blood pressure. Publication Status: Online-Only"
> "Q61481-4","RefSeq","NP_058024.2","22012077","These results suggest that induction of PDE1A plays a critical role in cardiac fibroblast activation and cardiac fibrosis"
> "Q61481-4","RefSeq","NP_058024.2","15901640","New variant PDE1A_v7 is the major form of cyclic nucleotide phosphodiesterase 1A expressed in mature sperm and is therefore likely to play an important role in cyclic nucleotide regulation of mature sperm function."
118a169,172
> "P49919-1","RefSeq","NP_034006.3","30284969","We propose that CDKN1c activity is restricted to differentiating myoblasts by regulated cyto-nuclear relocalization, coordinating the balance between proliferation and growth arrest. Publication Status: Online-Only"
> "P49919-1","RefSeq","NP_034006.3","17517131","Cdkn1c, an imprinted gene with expression only from the maternal allele, is the major regulator of embryonic growth in the IC2 imprinted domain on mouse distal chromosome 7. Publication Status: Online-Only"
> "Q9R1T4-1","RefSeq","NP_064326.2","29400567","Sept6 and Pigx might participate in the pathogenesis of high blood pressure."
> "Q9R1T4-1","RefSeq","NP_064326.2","28751190","Data suggest a regulatory role for septin 6 in long-term hematopoietic stem cells (HSCs) function and lymphoid lineage differentiation."
119a174,176
> "Q9QUK3-1","RefSeq","NP_036130.1","30397314","Ceroid-lipofuscinosis neuronal 8 protein (Cln8) knockout strain, which bears an early frameshift mutation in Cln8 that causes CLN8 protein deficiency and features resembling those seen in Batten disease."
> "Q9QUK3-1","RefSeq","NP_036130.1","22569358","This study demonistrated that Selective spatiotemporal patterns of glial activation and neuron loss in the sensory thalamocortical pathways in neuronal ceroid lipofuscinosis 8 decifiency mice."
> "Q9QUK3-1","RefSeq","NP_036130.1","22302580","This study demonistrated that the changes in glutamate receptor expression in the hippocampus of the mnd mouse."
124,127c181,184
< "Q8BGC0-1","RefSeq","NP_082518.1","24352707","Our results predict sex as a determinant of HIV effects in brain. Increased behavioral deficits in males correlated with glial activation and synaptic damage, both of which are implicated in cognitive/motor impairments in patients."
< "Q8BGC0-1","RefSeq","NP_082518.1","15485897","CA150 FF domains recognize multiple sites within the Tat-SF1 protein conforming to the consensus motif (D/E)(2/5)-F/W/Y-(D/E)(2/5)."
< "Q8CEC0-1","RefSeq","NP_001076800.1","18621024","Nup88 regulates the activity of NF-kappaB at the level of nucleocytoplasmic transport."
< "Q8CEC0-1","RefSeq","NP_001076800.1","18606815","Nup88 is up-regulated in response to hypertonic stress and acts to retain TonEBP in the nucleus, activating transcription of critical osmoprotective genes."
---
> "Q9WV69-1","RefSeq","NP_038542.1","27073223","Results demonstrate that dematin plays a critical role in maintaining the fundamental properties of the membrane cytoskeleton complex."
> "Q9WV69-1","RefSeq","NP_038542.1","23060452","The headpiece domain of dematin regulates calcium mobilization and signaling in platelets"
> "Q9WV69-1","RefSeq","NP_038542.1","21084299","Remodeling of the host cell directed Plasmodium includes the recruitment of dematin, an actin-binding protein of the erythrocyte membrane skeleton and its repositioning to the parasite"
> "Q9JI90-1","RefSeq","NP_064396.2","24472305","RNF14 influences the expression of both mitochondrial and immune related genes Publication Status: Online-Only"
133a191,195
> "P05063-1","RefSeq","NP_033787.2","29909450","In the Neurog2(-/-) mouse, in addition to the normal Purkinje cell expression, zebrin II is also expressed in a population of cells with a morphology characteristic of microglia. This identity was confirmed by double immunohistochemistry for zebrin II and the microglial marker, Iba1. The expression of zebrin II in cerebellar microglia is not restricted by zone or stripe or lamina."
> "B5KM66-1","RefSeq","NP_001156354.1","21637789","SYCE3 is required for male and female fertility."
> "B5KM66-1","RefSeq","NP_001156354.1","20407872","TSEG-2 may participate in the apoptosis of spermatogenic cells and the pathogenesis of cryptorchidism."
> "B5KM66-1","RefSeq","NP_001156354.1","19323366","A novel mouse testis specific gene TSEG-2 was successfully cloned, which could be down-regulated by cryptorchidism-inducible 17-beta estradiol. [TSEG-2]"
> "B5KM66-1","RefSeq","NP_001156354.1","17660561","Transcripts highly enriched in ovary; gene identified as candidate female fertility factor."
134a197
> "Q6UL01-1","RefSeq","NP_919245.1","19913896","MOPT is associated with dynamic regulation of acrosome biogenesis during late spermiogenesis."
137a201,202
> "Q64692-1","RefSeq","NP_033209.1","26153130","Results demonstrate that the early development of calbindin-positive periglomerular interneurons depends on the presentation of polysialic acid on NCAM and requires the activity of both St8sia2 and St8sia4"
> "Q64692-1","RefSeq","NP_033209.1","25885924","NCAM-140 significantly promoted cell proliferation, motility and migration, while polysialylation of NCAM-140 catalyzed by STX, but not by PST, enhanced NCAM-mediated cell migration, but not cell proliferation or motility. Publication Status: Online-Only"
144a210,212
> "Q4V9Z5-1","RefSeq","NP_659175.1","29979789","Results show that NPC1 loss-of-function in a mouse model of Niemann-Pick type C disease leads to enhanced cleavage of BACE1 substrates Sez6 and Sez6L, in addition to APP, and that this effect most likely involves altered trafficking of BACE1 and of its substrates within the endolysosomal system. Efficacy of Sez6 cleavage by BACE1 may be spatiotemporally differently regulated in contrast to the cleavage of Sez6L. Publication Status: Online-Only"
> "Q4V9Z5-1","RefSeq","NP_659175.1","29032200","Sez6l2 is one of the auxiliary subunits of the AMPA receptor and acts as a scaffolding protein to link GluR1 to ADD. Furthermore, Sez6l2 overexpression upregulates ADD phosphorylation, whereas siRNA-mediated downregulation of Sez612 prevents ADD phosphorylation, suggesting that Sez6l2 modulates AMPA-ADD signal transduction."
> "Q4V9Z5-1","RefSeq","NP_659175.1","19242545","Sez6l2 expression in mouse embryos was restricted to the spinal cord and brain"
148a217,219
> "Q9D3A9-1","RefSeq","NP_067299.2","30177553","Ttyh1 enhances embryonic neural stem cell properties.Ttyh1 increases Notch target gene expression."
> "Q9D3A9-1","RefSeq","NP_067299.2","28607172","In this report, we identify tweety-homolog 1 (Ttyh1), a membrane protein linked to neuronal development, as a potent driver of tumor microtube (TM)-mediated brain colonization by glioma cells."
> "Q9D3A9-1","RefSeq","NP_067299.2","20568244","Ttyh1 plays an indispensable role during mitosis in early embryogenesis, possibly by maintaining Ca(2+) homeostasis in the ER."
151,155c222,227
< "Q3UHN9-1","RefSeq","NP_001335029.1","29688404","An essential role for Heparin sulfate proteoglycan sulfation via NDST1,2,3 in modulating signal transduction during mouse implantation."
< "Q3UHN9-1","RefSeq","NP_001335029.1","29330473","Tubulo-interstitial macrophage influx and fibrosis are reduced by endothelial Ndst1 deficiency in experimental diabetes."
< "Q1ERP8-1","RefSeq","NP_001154184.1","24376728","Nepmucin/CD300LG expression in microvascular endothelial cells Publication Status: Online-Only"
< "Q1ERP8-1","RefSeq","NP_001154184.1","18675811","These results suggest that endothelial nepmucin promotes lymphocyte transendothelial migration using multiple adhesion pathways."
< "Q1ERP8-1","RefSeq","NP_001154184.1","16754720","Nepmucin may serve as a dual-functioning in peripheral node addressin in endothial venules mediating both lymphocyte rolling and binding via different functional domains."
---
> "Q8BHE4-1","RefSeq","NP_848753.1","28096412","Tmem108 is enriched in DG granule neurons. Its expression increased at the postnatal period critical for DG development. Tmem108 is specifically expressed in the nervous system and enriched in the postsynaptic density fraction. Tmem108 is required for spine formation and maturation and AMPA receptor expression. EPSCs were decreased in Tmem108 mutant mice, which have compromised sensorimotor gating and cognitive functions."
> "Q8BHE4-1","RefSeq","NP_848753.1","21849472","Retrolinkin functions in the endocytic trafficking of BDNF-TrkB and mediates BDNF-triggered ERK signaling in CNS neurons"
> "O54792-1","RefSeq","NP_032262.2","24015274","The transcription and expression patterns of Notch pathway components (Notch 1-3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated in the mouse testis Publication Status: Online-Only"
> "Q8BPQ7-1","RefSeq","NP_766306.2","25220469","Crystal structure of the Rab9A-RUTBC2 Rab-binding domain complex reveals that RUTBC2 Rab-binding doamin adopts a PH domain fold and mainly uses beta1 and eta1 insertion to bind Rab9A."
> "Q8BPQ7-1","RefSeq","NP_766306.2","19765553","Overall, the expression pattern of NuIP in adult mouse brain suggests that it may be involved in motor activity control in basal ganglia as well as higher central nervous system (CNS) functions such as cognition and memory in cortex and hippocampus."
> "P16125-1","RefSeq","NP_032518.1","27738103","These results identified a previously unrecognized Ldhb-driven alteration in muscle mitochondrial function and suggested a mechanism for the adaptive metabolic response induced by exercise training."
162,166c234,236
< "Q3UHD9-1","RefSeq","NP_001028435.1","28404596","Depletion of PIKE-A in C2C12 myotubes diminished the inhibitory activities of TNF-alpha on mitochondrial respiration and lipid oxidation, whereas PIKE-A overexpression exacerbated these cellular responses."
< "Q3UHD9-1","RefSeq","NP_001028435.1","28096359","Dopamine and DOPAC were not changed in 3-mo-old mice but were decreased at 8 mo in the striatum of PIKE-KO mice compared with wild-type mice.  DA and DOPAC in hippocampus and substantia nigra were significantly decreased in 3-mo-old and 8-mo-old PIKE-KO mice as compared with wild-type mice. More severe motor defects in PIKE-KO and Fyn-KO mice than in wild-type mice exposed to alpha synuclein and MPTP."
< "Q3UHD9-1","RefSeq","NP_001028435.1","24449917","PIKE plays pivotal roles to advance oligodendroglia development and myelinogenesis through Akt/mTOR activation."
< "Q3UHD9-1","RefSeq","NP_001028435.1","20068140","PIKE knockout mice show augmented lipid oxidation, which is accompanied by enhanced AMPK phosphorylation in muscle and adipose tissue and is implicated in obesity and diabetes development."
< "Q3UHD9-1","RefSeq","NP_001028435.1","18469807","PIKE-L acts as a downstream survival effector for netrin-1 through UNC5B in the nervous system"
---
> "Q8CIE4-1","RefSeq","NP_001157048.1","30097860","Murine Artd8 macrodomain constructs can serve as a tool to evaluate intracellular ARTD10 auto-modification levels using the described methods, while the human ARTD8 macrodomains are less suited because of ADPr-independent binding to ARTD10. Protocols for co-immunoprecipitation and co-localization experiments are described in detail."
> "Q9D0L1-1","RefSeq","NP_082382.1","28992324","The loss of maternal Zbed3 results in asymmetric zygotic division and abnormal distributions of organelles in the affected oocytes and zygotes, similar to the phenotypes observed in females with disrupted core subcortical maternal complex genes."
> "Q9D0L1-1","RefSeq","NP_082382.1","19141611","Zbed3 is a novel Axin-binding protein that is involved in Wnt/beta-catenin signaling modulation."
167a238,245
> "P56812-1","RefSeq","NP_062720.1","29588416","Serum PDCD5 levels reflect endothelial NO production and are correlated with diabetes mellitus, high-density lipoprotein cholesterol, and coronary calcium"
> "P56812-1","RefSeq","NP_062720.1","28542142","Pdcd5 knockout in mouse embryos results in placental defects and embryonic lethality. Publication Status: Online-Only"
> "P56812-1","RefSeq","NP_062720.1","27846830","These data demonstrate an association between level of PDCD5 and asthma severity and indicate that PDCD5 may play a role in allergic asthma. Publication Status: Online-Only"
> "P56812-1","RefSeq","NP_062720.1","27608954","PDCD5 gene knockout mice presented obvious improved brain blood flow, improved neurological behavior and decreased cerebral infarction compared with wild type mice. mice lacking PDCD5 had no changes in the expression of VHL and have slighter increases in the expression of HIF-1alpha and BNIP3, suggesting that PDCD5 may regulate apoptosis and autophagy through VHL-HIF-1alpha-BNIP3 pathway."
> "P56812-1","RefSeq","NP_062720.1","26077467","PDCD5 selectively mediates HDAC3 dissociation from p53, which induces HDAC3 cleavage and ubiquitin-dependent proteasomal degradation. This is a a mechanism for p53 activation via PDCD5-dependent HDAC3 decay under genotoxic stress conditions. Erratum:[Nat Commun. 2015;6:8225. Jeong, Jae-Ho [Corrected to Cheong, Jae-Ho]. PMID: 26293611] Publication Status: Online-Only"
> "P56812-1","RefSeq","NP_062720.1","22282256","It is implied that overexpression of PDCD5 causes the increase in caspase-3 activity and the subsequent increase of apoptosis in cochlear hair cells and SGNs, and thereby plays a role in the pathogenesis of presbycusis."
> "P56812-1","RefSeq","NP_062720.1","22177044","The expression levels of PDCD5 and caspase 3 in the cochlea of C57 mice increase with age."
> "P56812-1","RefSeq","NP_062720.1","17393091","Suppresses the pathogenicity of transplanted mouse erythroleukemia (MEL) cells in mice."
170,180c248,272
< "O70546-1","RefSeq","NP_001297373.1","30389724","Overexpression of the H3K27me3-specific demethylase KDM6A, but not of KDM6B, improves the efficiency of somatic cell nuclear transfer."
< "O70546-1","RefSeq","NP_001297373.1","30006524","Lymphomas with low UTX expression express high levels of Efnb1, and cause significantly poor survival. Publication Status: Online-Only"
< "Q9D6Y7-1","RefSeq","NP_001240641.1","30096435","It has been proposed that MsrA-dependent 14-3-3 zeta ubiquitination affects the regulation of alpha synuclein degradation and dopamine synthesis in the brain."
< "Q9D6Y7-1","RefSeq","NP_001240641.1","29649787","Our findings demonstrate that reversal of methionine oxidation is required for maintenance of cellular homeostasis in the absence of increased oxidative stress. These data provide the first link between autophagy and activation of Nrf2 in the setting of MsrA deletion"
< "Q9D6Y7-1","RefSeq","NP_001240641.1","29929200","MsrA knockout mice showed an increased sensitivity to noise at young and older ages, suggesting that MsrA is part of a mechanism that protects the cochlea from acoustic damage. MsrA mRNA in the cochlea was increased following acoustic stimulation."
< "Q9D6Y7-1","RefSeq","NP_001240641.1","28803836","MsrA protects against lipopolysaccharide-induced septic shock, and negatively regulates proinflammatory responses via inhibition of the ROS-MAPK-NF-kappaB signaling pathways."
< "Q9D6Y7-1","RefSeq","NP_001240641.1","28442342","Collectively, our results suggest that MsrA protects hepatocytes from APAP-induced cytotoxicity through the modulation of TXNRD1 expression."
< "Q9D6Y7-1","RefSeq","NP_001240641.1","15924425","Proper structure-function organization of MsrA plays a role in subcellular distribution of this protein in mouse cells."
< "Q9D6Y7-1","RefSeq","NP_001240641.1","12792026","Msra expression is regulated by (dietary)selenium"
< "P05017-1","RefSeq","NP_001104745.1","30915127","In osteocytes (but not osteoblasts), miR-29b-3p was responsive to the mechanical tensile strain and regulated osteoblast differentiation via regulating IGF-1 secretion of mechanically strained osteocytes. Publication Status: Online-Only"
< "P05017-1","RefSeq","NP_001104745.1","30808767","Hese data identify that dopamine neuron-derived IGF-1 acts as a regulator of dopamine neurons and regulates dopamine-mediated behaviors."
---
> "Q62158-1","RefSeq","NP_033080.2","29897614","The roles of Trim27 in hematopoiesis were studied by enforcing its expression in mouse hematopoietic stem and progenitor cells (HSPC). Ectopic expression of Trim27 in mouse fetal liver HSPC confers repopulating advantage with myeloid dominance. Trim27 up-regulated essential regulators of myelopoiesis.The myeloproliferative advantage caused by overexpressing Trim27/TRIM27 is conserved between mouse and human hematopoiesis."
> "Q62158-1","RefSeq","NP_033080.2","30143645","Deficiency of TRIM27 significantly impairs dextran sulfate sodium (DSS)-induced STAT3 activation, inflammatory cytokine expression and colitis as well as azoxymethane (AOM)/DSS-induced colitis-associated cancer in mice Publication Status: Online-Only"
> "Q62158-1","RefSeq","NP_033080.2","27612028","Trim27 connecting Slx2 may regulate meiotic processes in multiple ways by influencing XY body formation and germ cell proliferation during spermatogenesis."
> "Q62158-1","RefSeq","NP_033080.2","26607717","Our study suggests that nicotine may induce murine spermatozoal apoptosis via the TNF apoptotic pathway through up-regulation of deubiquitinated RIP1 by Trim27 promoter hypomethylation."
> "Q62158-1","RefSeq","NP_033080.2","26358190","TRIM27 inhibits VSV infection-induced type I IFN production by promoting TBK1 degradation."
> "Q8C551-1","RefSeq","NP_033039.2","23271971","VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages."
> "Q8C551-1","RefSeq","NP_033039.2","21307306","RAD51AP1 foci colocalize with a subset of DMC1 foci in spermatocytes."
> "P23611-1","RefSeq","NP_032346.1","31061494","Gene network analysis and conditional deletion revealed IRF8 as a master regulator that drives the maturation and diversity of brain macrophages"
> "P23611-1","RefSeq","NP_032346.1","24528256","We found that the transcriptional factor IRF8 plays a protective role in the cerebral ischaemic-reperfusion injury by attenuating neuronal apoptosis"
> "Q8BGD5-1","RefSeq","NP_710146.1","28472467","CPT1C in the mediobasal hypothalamus is necessary for proper hypothalamic sensing of a negative energy balance and fuel partitioning in liver and muscle."
> "Q8BGD5-1","RefSeq","NP_710146.1","26338711","Data newly identify CPT1C as a regulator of AMPAR translation efficiency and therefore also synaptic function in the hippocampus"
> "Q8BGD5-1","RefSeq","NP_710146.1","17559810","CPT1c is appropriately localized in regions and cell types to regulate energy homeostasis"
> "Q8BGD5-1","RefSeq","NP_710146.1","16651524","CPT1c is necessary for the regulation of energy homeostasis"
> "Q9Z2Y3-1","RefSeq","NP_687036.1","12176012","Molecular cloning of Homer1d, an alternativly splice isoform, that controls trafficking of group I metabotropic glutamate receptor"
> "E9PXX8-1","RefSeq","NP_001156608.1","25444928","Data suggest a critical role for MACC1 in lymphatic dissemination of GC, providing evidence that MACC1 upregulated VEGF-C/VEGF-D secretion to promote lymphangiogenesis via c-Met signaling."
> "E9PXX8-1","RefSeq","NP_001156608.1","24469707","HGF, MACC1 and C-met genes involve into malignant cervical tumors occurrence, development and prognosis, and might become potential molecular target therapy site of cervical cancer"
> "E9PXX8-1","RefSeq","NP_001156608.1","22484916","MACC1 has a role in colorectal cancer and can be used for imaging in xenografts"
> "E9PXX8-1","RefSeq","NP_001156608.1","19098908","MACC1 will be useful for the identification of poor prognosis subjects with colorectal cancer and is a promising new target for intervention in metastasis formation."
> "Q9ET78-1","RefSeq","NP_067541.1","30867288","RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure"
> "Q9ET78-1","RefSeq","NP_067541.1","30409805","Loss of nuclear JP2NT function accelerates stress-induced development of hypertrophy and heart failure in mutant mice"
> "Q9ET78-1","RefSeq","NP_067541.1","29632175","Physical interaction of junctophilin and the CaV1.1 C terminus is crucial for skeletal muscle contraction."
> "Q9ET78-1","RefSeq","NP_067541.1","29055091","Junctophilin 2, as junctional membrane complex (JMC) protein, is an important regulator of the cardiac SK channels"
> "Q9ET78-1","RefSeq","NP_067541.1","27909078","A 3-fold increase in the junctophilin-2 to RyR2 ratio is compatible with direct inhibition of RyR2 opening by junctophilin-2 to intrinsically stabilize the Ca2+ signaling properties of the junction and thus the contractile function of the cell."
> "Q09324-1","RefSeq","NP_775618.3","27505708","We show that Gcnt1 transcription and subsequent P-lselectin ligand induction in Th1 cells is governed by binding of STAT4 and T-bet to a distal enhancer and further regulated by epigenetic marks such as H3K27me3."
> "Q09324-1","RefSeq","NP_775618.3","23555902","Simultaneous deletion of the Core2 beta1,6-N-acetylglucosaminyltransferase (C2GnT) enzymes C2GnT1 and C2Gnt2 resulted in delayed expulsion of worms."
185a278,280
> "Q8VG45-1","RefSeq","NP_666987.1","29367680","These findings suggest that Olfr15 and Olfr821 in pancreatic beta-cells has a chemo-sensor function allowing recognition of environmental substances obtained from food, and potentiates insulin secretion in a cell-autonomous manner, thereby modulating systemic glucose metabolism. Publication Status: Online-Only"
> "Q9D424-1","RefSeq","NP_859420.2","27802166","It is the role of CABYR in the formation of the fibrous sheath that is essential for male fertility."
> "Q9D424-1","RefSeq","NP_859420.2","20731842","CABYR expresses at the late stage of spermiogenesis and its isoforms oligomerize and bind with AKAPs and ropporin; which suggests that CABYR participates in the assembly of the fibrous sheath. Publication Status: Online-Only"
187,191d281
< "Q99K48-1","RefSeq","NP_001239447.1","29673854","Nono overexpression increased the expression of pro-inflammatory cytokines leading to increased atherosclerotic plaque formation."
< "Q99K48-1","RefSeq","NP_001239447.1","29358041","NONO post-transcriptionally coordinates circadian mRNA expression of metabolic genes with the feeding/fasting cycle, thereby playing a critical role in energy homeostasis."
< "Q99K48-1","RefSeq","NP_001239447.1","28209515","NONO deficiency significantly compromises the response to ionizing radiation-induced DNA damage in the testes, consistent with cell type-specific loss of DSB repair capacity. The results provide evidence that this RNA binding protein significantly contributes to the DNA damage response in vivo."
< "Q91X46-1","RefSeq","NP_001276616.1","28542600","Data suggest that modulation of ARHGEF3 gene expression in humans with a promoter-localized SNP plays a role in human megakaryocytes and human platelet function-a finding resulting from the biological follow-up of human genetic studies. Arhgef3 KO mice partially recapitulate the human phenotype. Publication Status: Online-Only"
< "Q91X46-1","RefSeq","NP_001276616.1","23192023","The crystal structure of the tandemly arranged DH-PH domains of mouse Xpln, with a single molecule in the asymmetric unit, was determined at 1.79 A resolution (Xpln)"
196a287,292
> "Q3UNZ2-1","RefSeq","NP_001030044.1","29108956","GM853 is a stable protein that was not able to decarboxylate l-ornithine or l-lysine or act as an antizyme inhibitor. GM853 showed leucine decarboxylase activity, an activity never described in animal cells. By acting on l-leucine it produced isopentylamine, of unknown function. L-valine and l-isoleucine were poor substrates. Expression was mainly detected in the kidney, and it was stimulated by testosterone."
> "Q3UNZ2-1","RefSeq","NP_001030044.1","28607032","Characterization of an androgen-responsive, ornithine decarboxylase-related protein in mouse kidney. Publication Status: Online-Only"
> "Q99JW4-1","RefSeq","NP_080424.2","25609703","Findings suggest that PINCH-1 regulates integrin-mediated adhesion of keratinocytes through the interactions with ILK as well as EPLIN."
> "P53368-1","RefSeq","NP_032663.1","29281266","The crystal structures of mouse MTH1 in complex with inhibitor TH588 and dog MTH1 elucidate the structural and sequence basis for the observed difference in their affinities for TH588. Amino acid residue 116 in MTH1 is an important determinant of TH588 affinity. The structure of mouse MTH1 in complex with the substrate 8-oxo-dGTP is presented."
> "P53368-1","RefSeq","NP_032663.1","28067232","Increased cytotoxicity following MTH1 knockout or treatment with MTH1 inhibitor suggests the oxidation of precursor nucleotides. Publication Status: Online-Only"
> "Q921T2-1","RefSeq","NP_659040.2","24055652","LAP1 interacts physically and functionally with emerin and plays an essential and selective role in skeletal muscle maintenance."
205a302,308
> "Q9Z2P8-1","RefSeq","NP_058568.1","29330887","Loss of VAMP5 in mice results in duplication of the ureter and insufficient expansion of the lung"
> "Q9Z2P8-1","RefSeq","NP_058568.1","23180306","Study found that VAMP5 was expressed in the type IIa fibers of skeletal muscle and that in cardiomyocytes, VAMP5 expression was localized to the vicinity of intercalated discs"
> "Q9Z2P8-1","RefSeq","NP_058568.1","12682051","The cytoplasmic domain of this protein is responsible for its correct subcellular targeting."
> "Q99P87-1","RefSeq","NP_075360.1","30076527","Recombinant adiponectin and resistin, at a concentration found in the cerebrospinal fluid, have opposing effects on glucose metabolism."
> "Q99P87-1","RefSeq","NP_075360.1","30232730","Swimming exercises delayed the progression of atherosclerosis and prevents insulin resistance, possibly by upregulating miR-492 and downregulating resistin in aortic endothelium."
> "Q99P87-1","RefSeq","NP_075360.1","29925443","DNA methylation of adiponectin and resistin is affected by short chain fatty acids in a high fat diet"
> "Q99P87-1","RefSeq","NP_075360.1","29773580","Resistin and TLR4 are part of a new regulatory pathway of neuronal autophagy."
216a320
> "Q8C0R7-1","RefSeq","NP_001335266.1","20675388","ZMYND15 represents the first transcriptional repressor identified to be essential for sperm production and male fertility."
222a327
> "Q6A058-1","RefSeq","NP_080415.3","15759267","Has a role in specification or development of the interstitial cell lineage in the developing testis"
227,231d331
< "Q9JL26-1","RefSeq","NP_001071166.1","28361956","FMNL1 is required for actin assembly on lipid droplets (LDs) in vitro and for NMIIa recruitment to LDs in cells. We propose a novel acto-myosin structure regulating lipid storage: FMNL1-dependent assembly of myosin II-functionalized actin filaments on LDs facilitates their dissociation, thereby affecting LD surface-to-volume ratio and enzyme accessibility to triglycerides. Publication Status: Online-Only"
< "Q9JL26-1","RefSeq","NP_001071166.1","25447542","Depleting FMNL1, another Formin family member, resulted in reduced mDia1 expression, while RhoA inhibition did not alter mDia1 expression, which indicated that there was a FMNL1-mDia1-Profilin1 signaling pathway in mouse oocytes."
< "Q9JL26-1","RefSeq","NP_001071166.1","26083584","In oocyte meiosis, FMNL1 is required for spindle organization and actin assembly."
< "Q9JL26-1","RefSeq","NP_001071166.1","16556604","The bundling activities of FRL1 and mDia2, while producing phenotypically similar bundles, differ in mechanistic detail"
< "Q9JL26-1","RefSeq","NP_001071166.1","16480715","Binding to interphase microtubules through exon-2-encoded domain of Fmn1 provides a novel mechanism by which Fmn1 isoform Ib could coordinate actin filaments and microtubules."
237a338
> "Q08639-1","RefSeq","NP_033387.1","25940086","Kbtbd5 regulates skeletal muscle myogenesis through the regulation of E2F1-DP1 activity"
247a349
> "O35453-1","RefSeq","NP_032307.2","12962630","Crystal structure of human hepsin, confirming cleavage and association of the two chains"
248a351
> "Q3TY65-1","RefSeq","NP_081683.3","26306493","ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis."
252a356,361
> "Q7TQI0-1","RefSeq","NP_001001183.1","20439428","CLP24 is a novel regulator of VEGFR-2 and VEGFR-3 signaling pathways and of normal lymphatic vessel structure"
> "Q9DBE0-1","RefSeq","NP_659191.1","26327310","Taurine biosynthesis in vertebrates involves two structurally related PLP-dependent decarboxylases (cysteine sulfinic acid decarboxylase and glutamic acid decarboxylase like 1)"
> "Q9DBE0-1","RefSeq","NP_659191.1","25394658","Estradiol decreases taurine concentration mainly via the reduction of cysteine sulfinic acid decarboxylase expression level through the ER-alpha."
> "Q9DBE0-1","RefSeq","NP_659191.1","16252094","The results show that CSD is expressed both at the mRNA and protein levels in the testis, epididymis and ductus deferens."
> "Q9DBE0-1","RefSeq","NP_659191.1","11997111","CDNA sequence that predicts a polypeptide of 493 amino acids - both sequences given"
> "Q9R1P0-1","RefSeq","NP_036096.1","24668818","Data indicate that proteasome subunit alpha4 (alpha4s) is exclusively expressed in germ cells that enter the meiotic prophase."
254a364,368
> "P26149-1","RefSeq","NP_694873.2","23485106","Molecular chaperone-assisted folding of 3-beta hydroxysteroid dehydrogenase-2 is a physiological requirement"
> "O54751-1","RefSeq","NP_031796.1","30526792","CRX gene could induce the differentiation of Muller cell-derived progenitor into rod photoreceptors, indicating a new avenue to study muller cells as endogenous seed cells for retinal photoreceptor"
> "O54751-1","RefSeq","NP_031796.1","30084954","A Crx-dependent gene regulatory network was unraveled involving presynaptic genes that encode cytomatrix-associated proteins governing the organization of the photoreceptor ribbon synapse but not the formation of ribbon structure."
> "O54751-1","RefSeq","NP_031796.1","30158147","Results demonstrate that the activity of CRX binding sites is highly dependent on sequence context, providing insight into photoreceptor gene regulation and illustrating functional principles of homeodomain binding sites that may be conserved in other cell types."
> "O54751-1","RefSeq","NP_031796.1","30068366","CRX is required for chromatin remodeling at only a subset of its binding sites, which undergo retina or neuronal specific activation during photoreceptor differentiation. Publication Status: Online-Only"
267a382,385
> "P97468-1","RefSeq","NP_032179.1","30576947","Findings show that chemerin-activated CMKLR1 regulation in inflammatory macrophages is largely GRK6 and beta-arrestin mediated, which may impact innate immunity and have therapeutic implications in rheumatic disease."
> "P97468-1","RefSeq","NP_032179.1","29556954","In a pregnant-mouse model, the embryo resorption rate of alpha-NETA group was higher than that in the negative control group. These results suggested that the inhibition of the chemerin/CMKLR1 signaling pathway can lead to the abortion of mouse embryos, and that chemerin/CMKLR1 may play an important role in the maintenance of early pregnancy possibly by regulating ERK1/2 phosphorylation."
> "P97468-1","RefSeq","NP_032179.1","28905319","PI3K inhibition attenuates hepatic steatosis and KC-mediated inflammation via down-regulation of CMKLR1 and NLRP3 in HFD mice"
> "P97468-1","RefSeq","NP_032179.1","15019996","Results provide a necessary basis for further studies of the gene regulation and function of this chemoattractant-like receptor and will be useful when manipulating the gene in the development of transgenic animal models."
273a392,394
> "P01193-1","RefSeq","NP_032921.1","30311908","In vitro inhibition of miR-103/107 causes a reduction in the number of Pomc-expressing cells and increases the proportion of Pomc progenitors differentiating into NPY neurons. Publication Status: Online-Only"
> "P01193-1","RefSeq","NP_032921.1","30307151","Continuous expression in the arcuate nucleus of the hypothalamus induces either anorexigenic or orexigenic effects depending on the nutritional status Publication Status: Online-Only"
> "Q810F8-1","RefSeq","NP_035663.1","20162674","Data show that the LacZ-marked Tbx10 expressing cells are likely to be a subpopulation of interneurons in the ventral pons."
278,279d398
< "Q3UPW2-1","RefSeq","NP_001156603.1","27222093","ELF3 controls LCN2 expression in cooperation with NFkappaB."
< "Q3UPW2-1","RefSeq","NP_001156603.1","11893733","Evidence that mElf-3, a member of the Ets family, plays a key role in the activation of the mTbetaR-II promoter."
287d405
< "Q6ZPE2-1","RefSeq","NP_001074499.2","11994405","Expressed at high levels in seminiferous tubules of the testis; mice that are nullizygous for Sbf1 exhibit male infertility characterized by azoospermia."
288a407,409
> "Q3UQ17-1","RefSeq","NP_001028496.1","31123254","Using an inducible knockout mouse model study reveals essential role for Ddx5 in spermatogonial maintenance and show that Ddx5 is indispensable for male fertility. Ddx5 regulates appropriate splicing of key genes necessary for spermatogenesis and can also act as a transcriptional co-activator. Ddx5 interacts with PLZF, a transcription factor required for germline maintenance, to co-regulate select target genes. Publication Status: Online-Only"
> "Q3UQ17-1","RefSeq","NP_001028496.1","31027502","Plzf expression was detected as early as embryonic day (E) 9.5 in Pax6(+) cells in the mouse brain, and was completely disappeared in telencephalon before the initiation of cortical neurogenesis. Loss of Plzf resulted in a smaller cerebral cortex with a decrease in the number of Tbr1(+) deep layer neurons due to a decrease of mitotic cell number in the ventricular zone of forebrain at early developmental stage. Publication Status: Online-Only"
> "Q3UQ17-1","RefSeq","NP_001028496.1","30374131","We show that Bcl11b in pro-T cells blocked expression of the E-protein antagonist Id2 (encoded by Id2) and the innate-response regulator PLZF (encoded by Zbtb16)."
297c418,421
< "Q924Z6-1","RefSeq","NP_001298072.1","22323606","Measurements of nuclear export rates and depletion studies clarified that nuclear export of actin is mediated by exportin 6."
---
> "P29754-1","RefSeq","NP_796296.1","30776402","Data suggests central AT1R recruitment in modulation of fear behaviors associated with CO2 inhalation via engagement of neurocircuits regulating homeostasis and defensive behaviors."
> "P29754-1","RefSeq","NP_796296.1","29993275","That angiotensin receptor type 1 activation and inflammation are primary factors in the development of glucose intolerance in a setting of metabolic syndrome and that the associated increase in SBP is primarily mediated by angiotensin receptor type 1 activation"
> "P29754-1","RefSeq","NP_796296.1","30181481","Results provide support of a direct role of BM-derived cells AT1R in Ang II-induced atherosclerosis burden and plaque vulnerability. AT1R activation promotes hepatic mRNA expression of cholesterol-metabolism-related genes and vascular mRNA expression of pro-inflammatory cytokines. Publication Status: Online-Only"
> "P29754-1","RefSeq","NP_796296.1","29990483","High AT1R expression is associated with acute lung injury."
299,305c423,428
< "Q3UUY6-1","RefSeq","NP_620089.2","20333396","Data show the distribution and subcellular localization of prominin-2 within the kidney in situ."
< "Q3UUY6-1","RefSeq","NP_620089.2","18536929","Prominin-2 is widely and abundantly expressed along the epithelia of various segments of the adult male genitourinary tract."
< "Q3UUY6-1","RefSeq","NP_620089.2","17874118","Expression Prominin-2, in the three pairs of major salivary glands, i.e., submandibular-, major sublingual-, and parotid glands in adult mice."
< "Q3UUY6-1","RefSeq","NP_620089.2","17109118","These data show that all the characteristics of prominin-1 are shared by prominin-2, which is in agreement with a possible redundancy in their role as potential organizers of plasma membrane protrusions."
< "Q3UUY6-1","RefSeq","NP_620089.2","12514187","Identification as well as molecular and cell biological characterization"
< "Q69ZW3-1","RefSeq","NP_001239444.1","15247266","EHD1 and EHBP1, but not EHD2, are required for perinuclear localization of GLUT4 and reveal that loss of EHBP1 disrupts insulin-regulated GLUT4 recycling in cultured adipocytes."
< "Q69ZW3-1","RefSeq","NP_001239444.1","14676205","EHBP1 is an EH domain binding protein that, along with EHD2, has a role in coupling endocytosis to the actin cytoskeleton [EHBP1]"
---
> "P25425-1","RefSeq","NP_945151.2","30247265","This findings of this study indicated that OCT1 may participate in neuropathic pain at least in part by transcriptionally activating Dnmt3a and subsequently epigenetic silencing of Oprm1 and Kcan2 in the DRG."
> "P25425-1","RefSeq","NP_945151.2","30683852","CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGgamma. Publication Status: Online-Only"
> "P25425-1","RefSeq","NP_945151.2","28537559","In embryonic stem cells, Oct1 co-occupies a specific set of targets with Oct4, but does not occupy differentially expressed developmental targets. Instead, Oct1 occupies these targets as cells differentiate and Oct4 declines. Publication Status: Online-Only"
> "P25425-1","RefSeq","NP_945151.2","28199510","At low oxLDL levels LOX-1 activates the protective Oct-1/SIRT1 pathway, while at higher levels of the lipoprotein switches to the thrombogenic ERK1/2 pathway."
> "P25425-1","RefSeq","NP_945151.2","28362799","Study conclude that pentamidine interacts with multiple transporters, is taken into brain endothelial cells by OCT1 transporter and is extruded into the blood by ATP-dependent mechanisms. These interactions along with the predominant presence of OCT1 in the luminal membrane of the BBB contribute to the limited entry of pentamidine into the brain. Publication Status: Online-Only"
> "P97333-1","RefSeq","NP_032763.2","30355201","Nrp1 signaling mediated accumulation of Tregs within tumor might play a critical role in exacerbating ischemic brain injury in cancer-bearing mice."
310a434
> "Q8K0U8-1","RefSeq","NP_031702.3","22302612","PSG16 does not mediate CEACAM1a-independent spread of murine coronavirus."
313a438,444
> "P60853-1","RefSeq","NP_955396.2","31239441","Lzts1 functions as a master modulator of cellular dynamics, contributing to increasing complexity of the cerebral architecture during evolution. Publication Status: Online-Only"
> "P60853-1","RefSeq","NP_955396.2","26490870","The results of this study provide a novel Rap2-specific regulatory mechanism in synaptic maturation involving PSD-Zip70."
> "P60853-1","RefSeq","NP_955396.2","22419569","Taken together, the spatial and temporal distribution of Lzts1 is consistent with a potential function(s) in cell cycle regulation, axon growth or guidance, and/or migration of neurons."
> "P60853-1","RefSeq","NP_955396.2","18192690","Loss of one or both LZTS1 alleles hampers the normal defenses of urothelial cells against carcinogens, favoring bladder cancer development, which may make FEZ1 a target for gene therapy."
> "P60853-1","RefSeq","NP_955396.2","17419986","Partial or complete loss of Lzts1 downregulates Cdc25C and inhibits Cdk1 activity during mitosis, leading to premature transition from metaphase to anaphase."
> "P60853-1","RefSeq","NP_955396.2","17349584","Lzts1 deficiency was associated with an increased incidence of both spontaneous and carcinogen-induced cancers in mice."
> "Q62179-1","RefSeq","NP_038687.2","21270411","Sema4B negatively regulates basophil-mediated T helper type (Th)2 cell and humoral memory responses."
314a446,448
> "P30873-1","RefSeq","NP_033242.1","25784603","This study showed that reduced expression of the Sstr1 which modulate antidepressant action in hippocampus."
> "P30873-1","RefSeq","NP_033242.1","25149275","The expression and localization of the three receptors (SSTR3-SSTR5) in wild-type (WT), single-knockout (SSTR1 KO) and double-knockout SSTR1/SSTR2 (DKO) mice, are reported."
> "P30873-1","RefSeq","NP_033242.1","22986312","SSTR1 was expressed in Kolliker's organ on E14, on cochlear duct hair cells & supporting cells on E17 and only on the organ of Corti at birth, increasing & peaking at P14 but dropping off at P21."
321a456,457
> "P62880-1","RefSeq","NP_034442.1","22917497","Results indicate that G protein beta2 (Gbeta2) is required for starvation-induced NF-kappaB activation and constitutive NF-kappaB activity."
> "P62880-1","RefSeq","NP_034442.1","20525682","G protein subunits beta1 and beta2 have different roles in neutrophil function, as revealed by gene expression silencing in primary mouse neutrophils"
326a463,465
> "O88932-1","RefSeq","NP_062638.1","26501103","Data show that KCNJ15 inward rectifier potassium channel and hyperpolarization-activated cyclic nucleotide-gated (HCN) channel currents are changed in Trisomic neuron. Publication Status: Online-Only"
> "O88932-1","RefSeq","NP_062638.1","22566534","It was shown that downregulation of Kcnj15 leads to increased insulin secretion in vitro and in vivo. The mechanism for regulating insulin secretion inolved a calcium-sensiong receptor."
> "O88932-1","RefSeq","NP_062638.1","21719736","In nonsecreting parietal cells, KCNJ15 is stored in vesicles distinct from the H(+)-K(+)-ATPase-enriched tubulovesicles. Furthermore, upon stimulation, KCNJ15 and H(+)-K(+)-ATPase both translocate to the apical membrane for active acid secretion."
330,333c469
< "Q8BJS4-1","RefSeq","NP_001192274.1","29995584","A fragment of SUN2 containing CC1, CC2, and the SUN domain model is reported."
< "Q8BJS4-1","RefSeq","NP_001192274.1","19509342","These results clearly indicate that SUN1 and SUN2 function critically in skeletal muscle cells for Syne-1 localization at the nuclear envelope, which is essential for proper myonuclear positioning."
< "Q8BJS4-1","RefSeq","NP_001192274.1","17452644","Sun2 is part of a membrane-spanning fibrillar complex that interconnects attached telomeres with cytoplasmic structures"
< "Q8BJS4-1","RefSeq","NP_001192274.1","17132086","SUN1 and SUN2 may form a physical interaction between the nuclear envelope and the centrosome"
---
> "Q8BFZ9-1","RefSeq","NP_705820.1","30135210","The erlin2 threonine to isoleucine 65 substitution inhibits erlin1/erlin2 complex-mediated inositol 1,4,5-trisphosphate receptor ubiquitination and phosphatidylinositol 3-phosphate binding."
351a488,490
> "Q8BGW8-1","RefSeq","NP_722481.1","28769032","These results suggest that Vgll2 may be both directly and indirectly involved in the programing of slow muscle fibers through the formation of the Vgll2-TEAD complex. Publication Status: Online-Only"
> "Q8BGW8-1","RefSeq","NP_722481.1","15287000","Vestigial like 2 homolog is required for muscle gene expression, in part by switching DNA binding of TEF-1 factors during muscle differentiation. GeneRIF: A transcription cofactor required for skeletal muscle differentiation that modifies DNA target selectivity of the Transcriptional Enhancer Factor-1 (TEF-1) transcription factors."
> "Q8BGW8-1","RefSeq","NP_722481.1","14762206","VITO-1 is a crucial new cofactor of the muscle regulatory programme; VITO-1, a new scalloped interaction domain-containing protein, binds to TEF1 in vitro and strongly stimulates transcription of a reporter plasmid together with TEF-1 Publication Status: Online-Only"
361,365d499
< "Q70IV5-1","RefSeq","NP_964001.2","29247678","Synemin plays an important regulatory role in the heart and that the consequences of its absence are profound."
< "Q70IV5-1","RefSeq","NP_964001.2","25567810","Suggest that synemin contributes to linkage between costameres and the contractile apparatus and that the absence of synemin results in decreased fiber size and increased sarcolemmal deformability and susceptibility to injury."
< "Q70IV5-1","RefSeq","NP_964001.2","17654553","Alpha- and beta-synemin transcripts and their encoded proteins colocalize in neurons, especially in the midbrain and pons."
< "Q70IV5-1","RefSeq","NP_964001.2","17356066","Dmn is expressed in reactive astrocytes in neurotrauma and interacts differentially with Vim and Gfap."
< "Q70IV5-1","RefSeq","NP_964001.2","16817202","Synemin gene encodes proteins belonging to the intermediate filament which confer resistance to mechanical stress and modulate cell shape."
377a512,515
> "Q02248-1","RefSeq","NP_031640.1","31194980","Hepatocellular carcinomas with mutations that activate beta-catenin are characterized by increased uptake of a fluorocholine tracer, and can be detected by PET scan."
> "O08575-1","RefSeq","NP_034295.1","30628662","Immunoglobulin enhancerbinding factor/hepatic leukemia factor oncogenic fusion protein (E2AHLF) enhances the EYA transcriptional coactivator and phosphatase 2 (Eya2) expression by binding to the promoter region containing the E2AHLFbinding consensus sequence. Eya2 knockdown in E2AHLFimmortalized cells resulted in reduced colonyforming efficiency."
> "P35377-1","RefSeq","NP_035142.1","26294734","Nociceptin opioid receptor agonists are promising drugs for treating pain in sickle cell anemia."
> "P35377-1","RefSeq","NP_035142.1","26290245","These knock-in mice have NOP receptors that function both in vitro and in vivo and have provided a detailed characterization of NOP receptors in brain, spinal cord, and DRG neurons."
378a517,518
> "Q9DBT5-1","RefSeq","NP_083055.1","25361754","A novel mouse model of transient hypercholesterolemia with concurrent nephrotic syndrome associated with defective Ampd2 function. Publication Status: Online-Only"
> "Q9DBT5-1","RefSeq","NP_083055.1","24755741","In diabetic mice, AMPD2 activation counterregulates AMPK and increases hepatic glucose production, in association with up-regulation of PEPCK and G6Pc."
389a530,534
> "P54254-1","RefSeq","NP_033150.2","30507379","We also found that brain-region-specific differences occur early in disease initiation and progression, and they are shared across the two mouse models of SCA1. This suggests different mechanisms of degeneration at work in the inferior olive and cerebellum Publication Status: Online-Only"
> "P54254-1","RefSeq","NP_033150.2","29953616","Sca-1(+) cardiac fibroblasts direct the type of immune cells infiltrating the heart during cardiac inflammation and drive the development of heart failure."
> "P54254-1","RefSeq","NP_033150.2","29860311","Furthermore, pharmacological inhibition of PAKs decreases ATXN1 levels in a mouse model of SCA1. To explore the potential of using PAK inhibitors in combination therapy, we combined the pharmacological inhibition of PAK with MSK1, a previously identified modulator of ATXN1, and examined their effects on ATXN1 levels. We found that inhibition of both pathways results in an additive decrease in ATXN1 levels."
> "P54254-1","RefSeq","NP_033150.2","29758256","Reduction of protein kinase A-mediated ATXN1-pS776 results in enhanced degradation of ATXN1 and improved cerebellar-dependent motor performance."
> "P54254-1","RefSeq","NP_033150.2","29533923","Expanded ATXN1 stimulates the proliferation of postnatal cerebellar stem cells in SCA1 mice. These hyperproliferating stem cells tended to differentiate into GABAergic inhibitory interneurons rather than astrocytes; this significantly increased the GABAergic inhibitory interneuron synaptic connections, disrupting cerebellar Purkinje cell function in a non-cell autonomous manner."
398a544,547
> "O88273-1","RefSeq","NP_035955.1","29794428","Grem2 knockdown inhibited cardiomyocyte differentiation, and this effect was similar to that of Notch1 pathway inhibition in vitro. Grem2 enhances the protective effect of cardiac progenitor cells on heart function in a mouse model of myocardial infarction."
> "O88273-1","RefSeq","NP_035955.1","27283840","Grem2 provides a molecular barrier that controls the extent of inflammatory cell infiltration by suppressing BMP2 after myocardial infarction."
> "O88273-1","RefSeq","NP_035955.1","17222801","We propose that PRDC might serve as a mediator to antagonize BMP-4 signaling by Wnt."
> "O88273-1","RefSeq","NP_035955.1","15039429","Ovarian PRDC expressed in granulosa cells could be involved in follicular development by antagonizing the actions of theca cell-derived Bone morphogenetic proteins"
400,403d548
< "Q61990-1","RefSeq","NP_001096635.1","29866654","Embryos lacking the KH domain poly(C) binding protein, Pcbp2, are selectively deficient in the definitive erythroid lineage. Compared to wild-type controls, transcript splicing analysis of the Pcbp2(-/-) embryonic liver reveals accentuated exclusion of an exon (exon 6) that encodes a highly conserved transcriptional control segment of the hematopoietic master regulator, Runx1. Publication Status: Online-Only"
< "Q61990-1","RefSeq","NP_001096635.1","29422543","These findings suggest that Hr mRNA expression is regulated at the post-transcriptional level via IRES-mediated translation control through interaction with PCPB2, but not in MUHH. Publication Status: Online-Only"
< "Q61990-1","RefSeq","NP_001096635.1","27215387","Study determined that PCBP2 specifically associates with components of this kinase cascade and regulates the activities of its downstream transcriptional coactivators. Publication Status: Online-Only"
< "Q61990-1","RefSeq","NP_001096635.1","26907686","Data suggest that PCBP2 regulates p73 expression via mRNA stability and p73-dependent biological function in ROS production and cellular senescence."
414a560,562
> "P70166-1","RefSeq","NP_031781.1","30335155","Using the 3'-UTRs of mouse Cpeb1, Btg4 and Cnot6l mRNAs, we deciphered the combinatorial code that controls developmental stage-specific translation during meiotic maturation"
> "P70166-1","RefSeq","NP_031781.1","29242136","CPEB1 level was increased in the basolateral amygdala (BLA) of model mice injected with Complete Freund's Adjuvant. CPEB1 knockdown in the BLA can relieve anxiety-like behaviors but not pain-like behaviors by heightening inhibitory transmission and restoring the excitatory/inhibitory balance in model mice."
> "P70166-1","RefSeq","NP_031781.1","26826184","DAZL and CPEB1 regulate mRNA translation during oocyte maturation."
418a567,571
> "Q91YI1-1","RefSeq","NP_663503.1","29173006","These data establish the interaction between ATG13 and ATG101 as a promising target in disease-settings where the inhibition of autophagy is desired."
> "Q91YI1-1","RefSeq","NP_663503.1","27304681","ATG7, but not ATG13 or ULK1 has a role in functional autophagy in glioblastoma development"
> "Q91YI1-1","RefSeq","NP_663503.1","26801615","ATG13 phosphorylation plays a crucial role in autophagy regulation."
> "Q91YI1-1","RefSeq","NP_663503.1","26644405","Atg13-deficient embryos show growth retardation and myocardial growth defects. Publication Status: Online-Only"
> "Q91YI1-1","RefSeq","NP_663503.1","26213203","Autophagy can be executed by mechanisms that are dependent or independent of the ULK1/2-ATG13 interaction."
439a593,595
> "P62696-1","RefSeq","NP_031799.1","30291584","Mutated Crybb2 is implicated in the development of schizophrenia."
> "P62696-1","RefSeq","NP_031799.1","29864422","Tmsb4X was up-regulated in Crybb2 mutant brain. Additionally, Tmsb4X was co-expressed with Crybb2 at actin-enriched cell ruffles. Over-expression of Tmsb4X in cultured hippocampal neurons inhibited dendritogenesis, which phenocopied Crybb2 knock-down."
> "P62696-1","RefSeq","NP_031799.1","27666820","In conclusion, CRYBB2 regulates expression of different lncRNAs to influence ovary development"
441a598,600
> "E9PWH2-1","RefSeq","NP_001156610.1","29729191","Gain-of-function and loss-of-function Card6 mouse models demonstrated that Card6 protected mice from insulin resistance, hepatic steatosis, and inflammatory responses upon high-fat diet administration. Mechanistically, Card6 interacted with and inhibited apoptosis signal-regulating kinase 1 (Ask1) and its subsequent downstream c-Jun N-terminal kinase/p38 signaling."
> "E9PWH2-1","RefSeq","NP_001156610.1","24777975","These data indicated that CARD6 serves as a novel cardioprotective factor via negative regulation of MEK kinase-1-dependent MEK-ERK1/2 and JNK1/2 signaling"
> "E9PWH2-1","RefSeq","NP_001156610.1","16418290","CARD6 is a regulator of NF-kappaB activation that modulates the functions of RICK protein"
443a603,605
> "Q61143-1","RefSeq","NP_038866.2","31099508","Trpc3 mRNA expression was significantly elevated in kidneys of Trpc6(-/-) mice underwent unilateral ureteral obstruction (UUO) while the levels did not change in kidneys of neither WT nor in New Zealand obese mice underwent UUO."
> "Q61143-1","RefSeq","NP_038866.2","30873821","This work indicates that TRPC6 exerts critical pathophysiological functions in placenta, and provides further evidence for a role of this channel in the homeostasis of cations like Zn and Fe."
> "Q61143-1","RefSeq","NP_038866.2","29958896","Results together suggested that miR-200b-3p inhibition reduced the currents of TRPC6, which led to the decrease of intracellular Ca(2+) concentration"
445a608,609
> "Q6NZA9-1","RefSeq","NP_001161460.1","25006164","TAF9B also regulates neuronal gene transcription in vivo. Publication Status: Online-Only"
> "Q6NZA9-1","RefSeq","NP_001161460.1","21576927","These observations suggest that although CINAP deletion in mice does not influence learning and memory behaviors, CINAP is required for restriction of locomotor and exploratory activities."
455a620,625
> "Q920Q2-1","RefSeq","NP_062516.2","28970491","Rev1 contributes to proper mitochondrial function via the PARP-NAD-SIRT1-PGC1A axis. Erratum:[Sci Rep. 2018 Mar 6;8(1):4245. PMID: 29511198] Publication Status: Online-Only"
> "Q920Q2-1","RefSeq","NP_062516.2","28498946","These data indicate that dysregulation of cellular Rev1 levels leads to the accumulation of mutations and suppression of cell death, which accelerates the tumorigenic activities of DNA-damaging agents."
> "Q920Q2-1","RefSeq","NP_062516.2","27683219","Rev1 could serve as a backup polymerase in base excision repair and could potentially contribute to activation-induced cytidine deaminase-initiated antibody diversification through this activity."
> "Q920Q2-1","RefSeq","NP_062516.2","27497692","The results support the idea that Rev1 is not essential for the cellular translesion DNA synthesis functions of DNA polymerase zeta in mammalian cells."
> "Q920Q2-1","RefSeq","NP_062516.2","26795561","REV1 promote PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18."
> "Q920Q2-1","RefSeq","NP_062516.2","15653636","The BRCT domain of Rev1 is involved in regulating DNA replication during the mutagenic bypass of spontaneous and induced DNA lesions. Publication Status: Online-Only"
460a631
> "Q02788-1","RefSeq","NP_666119.1","26908621","Gamma-sarcoglycan-null/Col6a2Deltaex5 (Col6a2 deficient) mice exhibit reduced muscle pathology compared with gamma-sarcoglycan-null mice. Specifically, fewer muscle fibers are degenerating, fiber size varies less. Surprisingly, in spite of this reduction in muscle pathology, muscle function is not significantly improved."
461a633,639
> "Q60611-1","RefSeq","NP_033148.2","30710091","Satb1 regulates the specific gene expression and function of effector Th17 cells in tissue inflammation. Publication Status: Online-Only"
> "Q60611-1","RefSeq","NP_033148.2","30560927","Study using a mouse model with reduced IL-2 signaling revealed that IL-2, possibly through the positioning of the genome organizer SATB1, modulates thymic-derived Treg cell epigenetic identity prior to Foxp3 expression. Publication Status: Online-Only"
> "Q60611-1","RefSeq","NP_033148.2","29442043","Satb1 promotes osteoclastogenesis by recruiting CREB-binding protein to upregulate miR-223 expression in chronic kidney disease-mineral and bone disorder"
> "Q60611-1","RefSeq","NP_033148.2","15851481","SATB1-mediated transcriptional repression is regulated by nuclear matrix binding"
> "Q60611-1","RefSeq","NP_033148.2","15814699","Essential role for SATB1 late in the development and maturation of CD8SP T cells"
> "Q60611-1","RefSeq","NP_033148.2","12692553","In thymocyte nuclei, SATB1 has a cage-like 'network' distribution circumscribing heterochromatin and selectively tethers specialized DNA sequences onto its network"
> "P62881-1","RefSeq","NP_619733.1","28687610","Stimulation of the ERK pathway in Gnb5(-/-) cells by epidermal growth factor restored M3R-stimulated insulin release to near normal levels. Identification of the novel role of Gbeta5-R7 in insulin secretion may lead to a new therapeutic approach for improving pancreatic beta-cell function"
465a644,647
> "Q6ZPQ6-1","RefSeq","NP_035386.1","26269578","Here we found that under high light intensities, RdgB2(-/-) mutant mice showed normal pupillary light responses and circadian photoentrainment"
> "Q8BHJ5-1","RefSeq","NP_109657.2","28612505","Our data suggest that Setd5 is required for maintaining PGC-associated genes and Setd5-associated protein complexes containing Tbl1xr1 and Ctr9, which in turn are likely involved in regulating germ cell-related genes in mESCs"
> "Q8BHJ5-1","RefSeq","NP_109657.2","28475176","SMRT/N-CoR repressor complex is involved in gene regulation during sperm differentiation since members of this complex, in particular TBL1XR1, interact with SLY in postmeiotic male germ cells."
> "Q8BHJ5-1","RefSeq","NP_109657.2","14980219","TBLR1 and TBL1 have roles in specific nuclear receptor-mediated gene activation events"
471c653,660
< "Q99N48-1","RefSeq","NP_113572.1","11773082","Synaptotagmin-like protein 3-a (Slp3-a) contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slp3-a specifically and directly binds the GTP-bound form of Rab27A."
---
> "P41731-1","RefSeq","NP_031679.1","28031320","In renal proximal tubules, CD63 determines the insertion of OCT2 into the proper membrane domain and mediates transporter regulation by trafficking processes."
> "P41731-1","RefSeq","NP_031679.1","27506299","TIMP1 signaling via CD63 leads to activation of hepatic stellate cells, which create an environment in the liver that increases its susceptibility to pancreatic tumor cells."
> "P41731-1","RefSeq","NP_031679.1","27531610","The Muted protein is important for the steady-state level of CD63."
> "P58390-1","RefSeq","NP_536713.1","30635400","Results indicate that FBXO-32 contributes to SK2 down-regulation and that the F-box domain is essential for FBXO-32 function."
> "P58390-1","RefSeq","NP_536713.1","29055091","Junctophilin 2, as junctional membrane complex (JMC) protein, is an important regulator of the cardiac SK channels"
> "P58390-1","RefSeq","NP_536713.1","28282037","SK2 channels regulate mitochondrial respiration and mitochondrial Ca(2+) uptake."
> "P58390-1","RefSeq","NP_536713.1","28175299","SK2 is nuclear in primary neurons and, unexpectedly, overexpressed SK2 is neurotoxic in a dose-dependent manner.. We also found that SK2 is hyperphosphorylated in the brain samples from a model of HD, the BACHD mice.Our results identify a novel regulator of mutant huntingtin-mediated neurotoxicity and provide a new target for developing developing therapies for Huntington disease"
> "P58390-1","RefSeq","NP_536713.1","27874831","Probing the responsible cellular mechanisms pinpoints a disturbance in the expression and function of small-conductance Ca(2+)-activated K(+) (SK) channels and reveals an important role for both SK2 and SK3 channels in normal regulation of serotinin (5-HT) neuronal excitability. Publication Status: Online-Only"
474a664,668
> "Q9R0Y5-1","RefSeq","NP_067490.1","24740601","In addition to AK1 and AK2, which we previously demonstrated are present in outer dense fibers and mitochondrial sheath of the mouse sperm tail, we show that another AK, AK8, is present in a third flagellar compartment, the axoneme."
> "Q9R0Y5-1","RefSeq","NP_067490.1","23447692","CaMKIalpha regulates AMP kinase-dependent, TORC-1-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation."
> "Q8K1H1-1","RefSeq","NP_666254.1","21670278","Results identify TRPC3 as a pivotal signaling gateway in Ca(2+)-dependent control of cardiac gene expression"
> "Q8K1H1-1","RefSeq","NP_666254.1","21436445","Tdrd7 nullizygosity causes cataract and glaucoma and arrest in spermatogenesis;TDRD7 coimmunoprecipitates with specific lens mRNAs; required for posttranscriptional control of mRNAs critical to normal lens development and RNA granule function"
> "Q8K1H1-1","RefSeq","NP_666254.1","17141210","Tudor-related proteins, which contain multiple repeats of the Tudor domain, constitute an evolutionarily conserved class of nuage components in the germ-line, and their localization or accumulation to nuage is likely conferred by a Tudor domain structure"
484a679
> "Q9CQX0-1","RefSeq","NP_080856.1","23515685","SiRNAs of OTUB2 impaired insulin secretion both under basal conditions and in cytokine-treated MIN6 cells"
497a693,695
> "A2AD83-1","RefSeq","NP_001177261.1","26711119","FRMD7 as a key regulator in establishing a neuronal circuit asymmetry"
> "A2AD83-1","RefSeq","NP_001177261.1","22128244","A novel splice variant of FRMD7 (FRMD7-S) with a shortened exon 4 relative to the original form of FRMD7 (FRMD7-FL) was identified from the cDNA of the human NT2 cell line and mouse fetal brain."
> "A2AD83-1","RefSeq","NP_001177261.1","19892780","FRMD7 expression is spatially and temporally regulated in human and mouse brain during embryonic and fetal development."
500a699,702
> "Q69ZK6-1","RefSeq","NP_001229325.1","28826851","JMJD1C ensures efficient generation and maintenance of induced pluripotent stem cells, at least partially through controlling the expression of microRNAs."
> "Q69ZK6-1","RefSeq","NP_001229325.1","28501567","Data suggest that Jmjd1c may participate in mitotic clonal expansion and the activation of the adipogenic transcription program during the induction phase of adipocyte differentiation in 3T3-L1 cells."
> "Q69ZK6-1","RefSeq","NP_001229325.1","27649575","These results indicate that JMJD1C has multiple functions during spermatogenesis through interactions with different partners during the spermatogenic stages Publication Status: Online-Only"
> "Q69ZK6-1","RefSeq","NP_001229325.1","26878175","JMJD1C is an important mediator of MLL-AF9- and HOXA9-driven leukemia stem cell function that is largely dispensable for hematopoietic stem cells function."
510a713,714
> "Q9R194-1","RefSeq","NP_034093.1","29466738","Myogenic differentiation is achieved through the specific interaction between Cry2 and Bclaf1, which stabilizes mRNAs encoding cyclin D1, a G1/S phase transition regulator, and Tmem176b, a transmembrane regulator for myogenic cell fusion."
> "Q9R194-1","RefSeq","NP_034093.1","29109286","Circadian clock cryptochrome proteins Cry1 and Cry2 regulate autoimmunity."
511a716,719
> "Q8K3W0-2","RefSeq","NP_851799.1","28436570","Bre enhances osteoblastic differentiation by promoting the Mdm2-mediated degradation of p53."
> "Q8K3W0-2","RefSeq","NP_851799.1","27001068","Results demonstrate a role for BRE in both replicative senescence and DNA damage-induced premature senescence. This can be attributed to BRE being required for BRCA1-A complex-driven HR DNA repair Publication Status: Online-Only"
> "Q8K3W0-2","RefSeq","NP_851799.1","24395041","Depletion of BRE also increased tumor cell apoptosis, and decreased both local and metastatic tumor growth."
> "Q8K3W0-2","RefSeq","NP_851799.1","14565866","A highly conserved gene in two species can generate alternative transcripts different in both of the sequence structure and expression pattern, as well as a similar class of transcripts resulting from unconventional transcript processing."
523a732,738
> "Q3ULZ2-1","RefSeq","NP_001192284.1","29742020","FHDC1 plays a role in coordinating cytoskeletal dynamics during normal cilia assembly."
> "Q8R216-1","RefSeq","NP_598521.1","29845740","The findings reveal the critical role for SIRT4 in the control of energy metabolism and meiotic apparatus during oocyte maturation and indicate that SIRT4 is an essential factor determining oocyte quality."
> "Q8R216-1","RefSeq","NP_598521.1","29777709","SIRT4 is downregulated in cardiomyocytes after myocardial ischemia-reperfusion (MI-R), ameliorates MI-R injury, preserves mitochondrial function and reduces cardiomyocyte apoptosis after MI-R."
> "Q8R216-1","RefSeq","NP_598521.1","28726069","Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in mice from multiple genetic backgrounds."
> "Q8R216-1","RefSeq","NP_598521.1","28380376","These findings identify a robust enzymatic activity for SIRT4, uncover a mechanism controlling branched-chain amino acid flux, and position SIRT4 as a crucial player maintaining insulin secretion and glucose homeostasis during aging."
> "Q8R216-1","RefSeq","NP_598521.1","27992564","MiR-497 modulates cardiac hypertrophy by targeting Sirt4 and may serve as a potential therapeutic substance in the course. Publication Status: Online-Only"
> "Q8R216-1","RefSeq","NP_598521.1","16959562","Controls insulin secretion in pancreatic beta cells; also transfers an ADP-ribosyl group from NAD to histones"
524a740,746
> "Q6P5C5-1","RefSeq","NP_082161.2","28775312","We showed that SMUG1 efficiently prevent genomic uracil accumulation, even in the presence of UNG, and identified mutational signatures associated with combined UNG and SMUG1 deficiency. Publication Status: Online-Only"
> "Q6P5C5-1","RefSeq","NP_082161.2","24771041","Nonetheless, using a highly MSH2-dependent mechanism, Ung(-/-) Smug1(-/-) mice can still produce detectable levels of switched isotypes, especially IgG1"
> "Q6P5C5-1","RefSeq","NP_082161.2","22447450","SMUG1 is the dominant glycosylase responsible for 5-hydroxymethyluracil-excision in mice as well as the major UNG-backup for U-excision."
> "Q6P5C5-1","RefSeq","NP_082161.2","12820976","The structure and specificity of SMUG1 have been solved."
> "O70145-1","RefSeq","NP_035007.1","29499563","We found that ROS formation and expression of p47(phox) and p67(phox), subunits of NADPH oxidase, were increased in AppTg mice but attenuated in AppTg/Cebpd(-/-) mice. Cebpd can up-regulate p47(phox) and p67(phox) transcription via a direct binding on their promoters, which results in an increase in intracellular oxidative stress"
> "O70145-1","RefSeq","NP_035007.1","28471497","Just as patients with chronic granulomatous disease who lack NADPH oxidase rarely develop SLE, NCF-2-null mice on a nonautoimmune background were susceptible to a chronic granulomatous disease-like opportunistic infection but did not develop lupus. In contrast, on a lupus-prone background, even haploinsufficiency of NCF-2 accelerated the development of full-blown lupus disease."
> "O70145-1","RefSeq","NP_035007.1","23401562","P67(phox) binds to phosphoPrdx6 and inhibits its PLA2 activity, an interaction that could function to terminate the PLA2-mediated NOX2 activation signal."
527a750
> "Q9JIB0-1","RefSeq","NP_067304.1","18184654","In cardiomyocytes, MOG1 is mostly localized in the cell membrane and co-localized with Nav1.5, indicating that MOG1 is a critical regulator of sodium channel function in the heart"
529a753,760
> "Q9QZ11-1","RefSeq","NP_036142.2","30312299","Mice homozygous for a point mutation (D173A) in Exo1 that eliminates its nuclease activity but retains its native conformation, shows a level of trinucleotide expansion that is intermediate between Exo1+/+ and Exo1-/- animals. Publication Status: Online-Only"
> "Q9QZ11-1","RefSeq","NP_036142.2","28711786","Like canonical DNA mismatch-repair proteins, EXO1 can restrain aberrant homologous recombination events between diverged sequence elements in the genome."
> "Q9QZ11-1","RefSeq","NP_036142.2","26160886","The results establish a key role for EXO1 in modulating the severity of hypomorphic MRE11 complex mutations."
> "Q9QZ11-1","RefSeq","NP_036142.2","12629043","Functions in mutation avoidance and is essential for male and female meiosis."
> "Q60700-1","RefSeq","NP_033608.3","29968565","DLK is required for mechanical allodynia and microgliosis after nerve injury by controling a transcriptional program in somatosensory neurons regulating the expression of numerous genes implicated in pain pathogenesis, including Csf1. Publication Status: Online-Only"
> "Q60700-1","RefSeq","NP_033608.3","28814543","These findings demonstrate that pathological activation of DLK is a conserved mechanism that regulates neurodegeneration."
> "Q60700-1","RefSeq","NP_033608.3","28641113","LZK cooperates with DLK to promote retinal ganglion cell death in response to axon injury."
> "Q60700-1","RefSeq","NP_033608.3","28440222","These findings identify DLK as a central regulator of not only JNK but also PERK stress signaling in neurons, with both pathways contributing to neurodegeneration. Publication Status: Online-Only"
534a766,771
> "Q9JLG4-1","RefSeq","NP_058623.2","21508103","All channel-forming isoforms of TRPP channels (polycystin-2, polycystin-L, and polycystin-2L2) were expressed in adult mouse lacrimal gland. Publication Status: Online-Only"
> "Q9JLG4-1","RefSeq","NP_058623.2","18670078","Pkd2l2 may be involved in the mid-late stage of spermatogenesis through modulation of the intracellular calcium concentration."
> "Q62048-1","RefSeq","NP_035193.1","30049418","This study shows that PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models"
> "Q62048-1","RefSeq","NP_035193.1","29928894","Epigenetic changes imposed at this region by diets, which impair glucose tolerance generate metabolic memory of the nutritional injury and leave Ped/Pea-15 induction in a poised state."
> "Q62048-1","RefSeq","NP_035193.1","27426254","The neurological and neurochemical phenotype of transgenic mice overexpressing PED/PEA-15 (tgPED), were analyzed. Publication Status: Online-Only"
> "Q62048-1","RefSeq","NP_035193.1","19917132","We suggest PEA-15 may be an essential regulator of ERK-dependent spatial learning. Publication Status: Online-Only"
539a777,792
> "P26039-1","RefSeq","NP_035732.2","30442677","Findings suggest that direct Rap1/Talin1 interaction is of particular importance in regulating the activity of different integrin classes expressed on platelets and neutrophils, which both depend on fast and dynamic integrin-mediated responses."
> "P26039-1","RefSeq","NP_035732.2","30420438","This study shows that Talin1 methylation is required for neutrophil infiltration during murine peritonitis"
> "P26039-1","RefSeq","NP_035732.2","30242097","The Rap1-talin 1 F0 interaction has little effect on platelet GPIIb-IIIa activation and hemostasis and cannot account for the dramatic effects of loss of Rap1 activity on these platelet functions."
> "Q91W10-1","RefSeq","NP_080504.3","29927321","Hepatic ZIP8 knockdown leads to selenium deficit, liver pathology, oxidative stress and tumor formation. Erratum:[Am J Physiol Gastrointest Liver Physiol. 2018 Nov 1;315(5):G908. PMID: 30444645]"
> "Q91W10-1","RefSeq","NP_080504.3","29337306","Slc39a8 is expressed in the developing heart and regulates Zn levels. Slc39a8 deletion results in hypertrabeculation and noncompaction."
> "Q91W10-1","RefSeq","NP_080504.3","28481222","ZIP8 reclaims Mn from bile and regulates whole-body Mn homeostasis."
> "Q91W10-1","RefSeq","NP_080504.3","28057442","Intravitreal holo-transferrin injection decreased Zip 14 protein levels. These data indicate that Zip8 and Zip14 may take up increasing amounts of non-transferrin bound iron in these two mouse models of retinal iron accumulation."
> "Q91W10-1","RefSeq","NP_080504.3","17108009","Cd treatment caused acute renal failure and signs of proximal tubular damage in the BTZIP8-3 but not nontransgenic littermates. BTZIP8-3 mice should be a useful model for studying Cd-induced disease in kidney."
> "Q8BG60-1","RefSeq","NP_076208.2","30138646","This study showed that the thioredoxin-interacting protein in brain increase after exposed to chronic stress."
> "Q8BG60-1","RefSeq","NP_076208.2","30168649","TXNIP regulates cellular senescence by inhibiting AKT pathways via a direct interaction under conditions of glucose-derived metabolic stress."
> "Q8BG60-1","RefSeq","NP_076208.2","30142540","TXNIP facilitates the oxidative stress response in glomerular mesangial cells partially through AMPK pathway."
> "Q8BG60-1","RefSeq","NP_076208.2","29884908","Our study suggests that TXNIP plays a key role in the renal inflammation and fibrosis induced by unilateral ureteral obstruction. The expression of TXNIP was increased in a time-dependent manner in the ligated kidneys."
> "Q4FZC9-1","RefSeq","NP_766088.2","23761073","Nesprin-3 is critical for the localization of plectin to the nuclear perimeter of Sertoli cells."
> "Q4FZC9-1","RefSeq","NP_766088.2","23336069","Data indicate roles for linkers of nucleus to cytoskeleton (LINC) molecules nesprin2giant and nesprin3, which anchor actin cap fibers to the nucleus."
> "Q4FZC9-1","RefSeq","NP_766088.2","17881500","Data support a model in which the actin cytoskeleton influences the binding of plectin dimers to dimers of nesprin-3alpha, which in turn are retained at the nuclear envelope through an interaction with Sun proteins."
> "Q4FZC9-1","RefSeq","NP_766088.2","16330710","Plectin binds to the integrin alpha6beta4 at the cell surface and to nesprin-3 at the ONM in keratinocytes."
548a802,803
> "Q8C4U3-1","RefSeq","NP_038862.2","30586565","Low Sfrp1 expression is associated with pulmonary fibrosis."
> "Q8C4U3-1","RefSeq","NP_038862.2","29215727","SFRP1 regulates spinal nerve ligation-induced mechanical allodynia and thermal hyperalgesia through the Wnt/beta-catenin signaling pathway involved in neuropathic pain."
551,554c806,813
< "O08785-1","RefSeq","NP_001276755.1","30530698","HNF4A strongly transrepresses the transcriptional activity of the CLOCK:BMAL1 heterodimer."
< "O08785-1","RefSeq","NP_001276755.1","30413606","The predicted CLOCK regulated miRNAs at two time points participated in extremely diverse pathways. The study validated nine miRNAs (miR-125a-3p, miR-144, miR-199a-5p, miR-199b*, miR-200a, miR-200b, miR-203, miR-449a, and miR-96), which were involved in the same signaling pathway-hippo signaling pathway. Publication Status: Online-Only"
< "O08785-1","RefSeq","NP_001276755.1","30124738","Results indicate that circadian locomotor output cycles kaput protein (CLOCK) overexpression triggers the formation of atherosclerotic plaques by directly upregulating plasminogen activator inhibitor 1 (PAI-1) expression."
< "O08785-1","RefSeq","NP_001276755.1","30695595","Carcinogenic exposure decreased BMAL1 and CRYI- expression in the skin, CLOCK expression was upregulated and CRYl downregulated in tumor compared to normal skin. BMAL1 expression increased under disrupted light regimen; melatonin treatment affected CLOCK expression in tumors and CRYI in skin at the carcinogens application sites."
---
> "P28310-1","RefSeq","NP_031876.1","30718392","We engineered a monoclonal antibody against HNP-1 to block the interaction with P2X7 and found that the blocking antibody protected mice carrying high copy number of DEFA1/DEFA3 from lethal sepsis. We thus demonstrate that DEFA1/DEFA3 copy number variation strongly modulates sepsis development in vivo and explore a paradigm for the precision treatment of sepsis tailored by individual genetic information."
> "P28310-1","RefSeq","NP_031876.1","11960772","Cryptdin 3 forms anion-selective channels on the cytoplasmic membrane of HEK cells and that the kinetics of one such channel are affected by its interaction with other such channels."
> "P28310-1","RefSeq","NP_031876.1","11733520","MMP-7-dependent procryptdin activation in vivo provides mouse Paneth cells with functional peptides for apical secretion into the small intestine lumen"
> "Q8CJC7-1","RefSeq","NP_705818.3","15069013","Mediates recognition and rejection of allogeneic target cells in the host immune system"
> "Q8CJC7-1","RefSeq","NP_705818.3","12782717","Cloning and functional characterization of a novel natural killer (NK) cell receptor termed KLRE1"
> "Q61334-1","RefSeq","NP_031556.1","15187134","Results are consistent with the view that class I molecules are largely recruited to ER exit sites by Bap29/31, and that Bap29/31 is a cargo receptor for MHC class I molecules"
> "Q61334-1","RefSeq","NP_031556.1","12886015","A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum."
> "Q7TSH2-1","RefSeq","NP_955517.1","18549242","The interactions described herein between the beta subunit of PhK and GAPDH provide a possible mechanism for the direct linkage of glycogenolysis and glycolysis in skeletal muscle."
561a821,825
> "Q68FG0-1","RefSeq","NP_001276626.1","30177510","RNF220 interacts with, and is co-expressed with, a zinc-finger protein ZC4H2, and they cooperate to degrade Dbx1/2 and Nkx2.2. Co-expression of RNF220 and ZC4H2 further promotes the ability of Nkx6.1 to induce ectopic Chx10+ V2 interneurons. Publication Status: Online-Only"
> "Q68FG0-1","RefSeq","NP_001276626.1","28814648","Results demonstrate that ZC4H2 promotes BMP signaling and is involved in BMP regulated myogenic and osteogenic differentiation of mouse myoblast cells."
> "Q68FG0-1","RefSeq","NP_001276626.1","23623388","In mouse primary hippocampal neurons, transiently produced ZC4H2 localized to the postsynaptic compartment of excitatory synapses, and the altered protein influenced dendritic spine density."
> "Q6P8Y0-1","RefSeq","NP_083611.2","17971504","1700026D08Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
> "Q99PM3-1","RefSeq","NP_780544.1","25664857","TFIIA is the principal TASP1 substrate that orchestrates craniofacial morphogenesis."
566a831,834
> "Q62219-1","RefSeq","NP_001276482.1","29242607","High HIC5 expression is associated with tumorigenesis of colorectal cancer."
> "Q62219-1","RefSeq","NP_001276482.1","27893716","Isolated Hic-5(-/-);PyMT CAFs were defective in stress fiber organization and exhibited reduced contractility. These cells also failed to efficiently deposit and organize the ECM in two and three dimensions. This, in turn, impacted three-dimensional MDA-MB-231 tumor cell migration behavior"
> "Q62219-1","RefSeq","NP_001276482.1","28139974","Together, the authors show the antagonistic regulation of the alpha-enhancer activity by Pax6 and the LIM protein complex is necessary for the establishment of an inner retinal circuitry, which controls visual adaptation. Publication Status: Online-Only"
> "Q62219-1","RefSeq","NP_001276482.1","27269065","Paxillin and Hic-5 have both redundant and distinctive functions in invadosome formation."
585a854,858
> "Q9ET80-1","RefSeq","NP_065629.1","29632175","Physical interaction of junctophilin and the CaV1.1 C terminus is crucial for skeletal muscle contraction."
> "Q9ET80-1","RefSeq","NP_065629.1","23148318","This study demonstrates that both JP1 and JP2 in skeletal muscle undergo Ca2+-dependent proteolysis by endogenous proteases when the intracellular Ca2+ is raised within the physiological range for a sustained period"
> "Q9ET80-1","RefSeq","NP_065629.1","22927069","JP1 gene is expressed during the whole process of cardiogenesis, while JP1 protein only appears during the early stage."
> "Q9ET80-1","RefSeq","NP_065629.1","14559359","We report a novel Junctophilin subtype, JP-4, encoded in the human (chromosome 14q11.1) and mouse (chromosome 14C1-2) genomes. JP-4 shares characteristic structural features with other JP subtypes, and is found in the brain."
> "Q9ET80-1","RefSeq","NP_065629.1","12729900","Abnormal junctional membrane structures in cardiac myocytes in transgenic mice expressing junctophilin type 1."
594a868,874
> "Q7TSA3-1","RefSeq","NP_808252.1","30134817","Soluble BTLA is produced as a result of alternative RNA splicing. This isoform of BTLA has biological significance through changes in cellular proliferation and can predict the diagnosis of sepsis. Publication Status: Online-Only"
> "Q7TSA3-1","RefSeq","NP_808252.1","29518903","These data support a role of BTLA on type I NKT cells in limiting anti-tumor immunity. Publication Status: Online-Only"
> "Q7TSA3-1","RefSeq","NP_808252.1","28393074","These data indicate that CCR7 and BTLA cooverexpression imparts an intermediate immune phenotype in mmature dendritic cells when compared to that in CCR7- or BTLA-expressing counterparts that show a more immunocompetent or immunotolerant phenotype"
> "Q7TSA3-1","RefSeq","NP_808252.1","28164546","The percentage of circulating BTLA+CD4+ lymphocytes was significantly higher in mice with LPS-induced acute lung inflammation."
> "Q7TSA3-1","RefSeq","NP_808252.1","27793593","Dendritic cells require BTLA and HVEM to actively adjust tolerizing T cell responses under steady-state conditions."
> "Q7TSA3-1","RefSeq","NP_808252.1","15128774","BTLA is expressed by all mature lymphocytes, splenic macrophages, and mature, but not immature bone marrow-derived dendritic cells. BTLA is implicated as a negative regulator of the activation and/or function of various hemopoietic cell types."
> "Q7TSA3-1","RefSeq","NP_808252.1","12796776","BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1)."
595a876,879
> "P61092-1","RefSeq","NP_033198.1","28843785","Depletion of KDM3A coincided with the loss of SIAH1 induction and the accumulation of dimethylated H3K9 surrounding the SIAH1 promoter. Interestingly, KDM3A expression was also up-regulated by nutritional stress in a HIF-1alpha dependent manner."
> "P61092-1","RefSeq","NP_033198.1","25561546","Combination of netrin-1 and SIAH RNAi may prove to be a substantially effective therapy for myocardial infarction."
> "P61092-1","RefSeq","NP_033198.1","23027902","The B23 regulates neuronal survival by preventing SIAH1-GAPDH death signaling under stress-induced conditions in the brain."
> "P61092-1","RefSeq","NP_033198.1","22132158","The present study demonstrated for the first time that zygotic specific miRNA modulates the first cell cleavage through regulating expression of Siah1a."
596a881,882
> "P43006-1","RefSeq","NP_035523.1","29722912","Nerve injury-induced neuropathic pain was enhanced in spinal cord-specific GLT1 knockout mice but alleviated in periaqueductal gray (PAG)-specific GLT1 knockout mice. In addition, ceftriaxone upregulated GLT1 expression in the spinal cord, but not the PAG, of control mice and attenuated tactile hypersensitivity in nerve-injured control mice but not in nerve-injured spinal cord-specific GLT1 knockout mice."
> "P43006-1","RefSeq","NP_035523.1","29880815","Data demonstrate that the interaction occurs between PS1 and GLT-1 expressed at their endogenous levels in vivo and in vitro, takes place in both neurons and astrocytes, and is independent of the PS1 autoproteolysis and gamma-secretase activity. Publication Status: Online-Only"
601a888
> "P16882-1","RefSeq","NP_034414.2","30295789","Chow-fed, adult-onset, hepatocyte-specific, GH receptor knockdown (aHepGHRkd) mice rapidly (within 7 days) develop steatosis associated with increased hepatic de novo lipogenesis, independent of changes in systemic metabolic function. 6 months after induction of aHepGHRkd early signs of NASH develop, which include hepatocyte ballooning, inflammation, signs of mild fibrosis, and elevated plasma alanine aminotransferase."
605a893,900
> "P67871-1","RefSeq","NP_034105.1","29483533","GLT8D1 and CSNK2B knockdown promote the proliferation and inhibit the differentiation abilities of neural stem cells, and alter morphology and synaptic transmission of mouse neurons. Erratum:[Nat Commun. 2018 Nov 16;9(1):4905. PMID: 30446647] Publication Status: Online-Only"
> "P67871-1","RefSeq","NP_034105.1","28928125","Thrombotic vascular occlusion in vivo was significantly blunted in ck2beta(-/-) mice, accompanied by a slight prolongation of bleeding time"
> "P67871-1","RefSeq","NP_034105.1","26108355","AMPKalpha signalling suppresses EMT and secretion of chemokines in renal tubular epithelia through interaction with CK2beta to attenuate renal injury."
> "Q9R0T8-1","RefSeq","NP_062751.2","30902986","The GEF-H1-IKKepsilon-IRF5 signaling axis functions independent of NOD-like receptors and is critically required for the recognition of intracellular peptidoglycans and host defenses against Listeria monocytogenes. Publication Status: Online-Only"
> "Q9R0T8-1","RefSeq","NP_062751.2","28481329","Virus-activated kinase IKKepsilon phosphorylated YAP at Ser403 and thereby triggered degradation of YAP in lysosomes and, consequently, relief of YAP-mediated inhibition of the cellular antiviral response. Erratum:[Nat Immunol. 2017 Oct 18;18(11):1270. PMID: 29044228]"
> "Q9R0T8-1","RefSeq","NP_062751.2","27346349","IKKepsilon promotes NFATc1 phosphorylation and inhibits T cell responses, identifying IKKepsilon as a crucial negative regulator of T cell activation and a potential target for immunotherapy."
> "Q9R0T8-1","RefSeq","NP_062751.2","15879144","In stimulated murine fibroblast-like synoviocyte cultures, induction of matrix metalloproteinases MMP3 and MMP13 is significantly greater in the IKK epsilon-positive cells compared with IKK epsilon-deficient cultures."
> "Q9R0T8-1","RefSeq","NP_062751.2","12736252","IKKi/IKKepsilon plays a key role in integrating signals induced by pro-inflammatory stimuli."
612a908
> "Q60682-1","RefSeq","NP_034780.1","27831490","Furthermore, Ly49/MHC-I interactions are diffusion-controlled and enthalpy-driven."
623a920,930
> "A2ALK8-1","RefSeq","NP_035337.2","22730326","P38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response."
> "A2ALK8-1","RefSeq","NP_035337.2","19107198","PTPN3 and PTPN4 are dispensable for TCR signal transduction."
> "A2ALK8-1","RefSeq","NP_035337.2","17921143","PTP-H1 has a role in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion"
> "P49586-1","RefSeq","NP_034111.1","26174230","The findings reported herein indicate that palmitate-induced cisternal endoplasmic reticulum expansion is dependent on the activation of XBP-1/CCTalpha-mediated phospholipid accumulation in RAW 264.7 cells. Publication Status: Online-Only"
> "P49586-1","RefSeq","NP_034111.1","23074967","Data suggest that CTalpha is an important factor in hepatocyte proliferation in vitro; however, liver regeneration, DNA synthesis, and phosphatidylcholine biosynthesis after partial hepatectomy are not impaired in CTalpha(-/-) knockout mice."
> "Q3U827-1","RefSeq","NP_082210.1","23926250","Rines is a critical regulator of the monoaminergic system and emotional behavior and identify a promising candidate drug target for treating diseases associated with emotion."
> "Q3U827-1","RefSeq","NP_082210.1","18363970","The involvement of RNF180 in the ubiquitin-proteasome pathway was further supported by its binding to the UbcH6 ubiquitin-conjugating enzyme and by its trans-ubiquitination enhancing activities."
> "Q6Q783-1","RefSeq","NP_666289.2","27920088","Expression of Suv4-20h2 leads to sustained levels of H4K20me3, developmental arrest, and defects in S-phase progression."
> "Q6Q783-1","RefSeq","NP_666289.2","26904956","Upregulation of long non-coding RNA PAPAS in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2."
> "Q6Q783-1","RefSeq","NP_666289.2","24768537","Results uncover a lncRNA-mediated mechanism that guides Suv4-20h2 to specific genomic loci to establish a more compact chromatin structure in growth-arrested cells."
> "Q6Q783-1","RefSeq","NP_666289.2","17846168","There is a novel role for histone lysine methylation in controlling telomere recombination."
629a937
> "Q99L20-1","RefSeq","NP_598755.1","12038961","Identification and characterization of GSTT3 [GSTT3]"
647a956,958
> "Q91WJ0-1","RefSeq","NP_659188.1","29155277","FRS2 and FRS3, are together required for postnatal brain development. In the hippocampus, FRS2&3 promote dentate gyrus morphogenesis and dentate granule cell (DGC) maturation during developmental neurogenesis. Frs2,3-double mutants have reduced numbers of dendritic branches and spines in DGCs. Double-mutant mice exhibit fewer excitatory synaptic inputs onto DGCs."
> "Q91WJ0-1","RefSeq","NP_659188.1","24465223","Analysis of a mutant Fgfr1 allele, unable to bind to the adaptor protein, Frs2/3, indicates that Sox2 maintenance can be"
> "Q91WJ0-1","RefSeq","NP_659188.1","12586769","Data indicate that the fibroblast growth factor receptor substrate 2 and fibroblast growth factor receptor substrate 3 adapters may have a role in thyroid carcinogenesis triggered by TRK oncogenes"
650,653d960
< "Q99JA4-1","RefSeq","NP_001268788.1","29916540","Montelukast also served a protective role in a murine ovariectomy (OVX) and unloadinginduced bone loss model. Altogether, these results confirmed that the CysLTR1 antagonist exerted an inhibitory effect on OC formation in vitro and in vivo. It may be useful for the treatment of bone diseases associated with excessive bone resorption."
< "Q99JA4-1","RefSeq","NP_001268788.1","29412178","These findings highlight the essential role of cysLT1R in suppressing pancreatic insulin secretion, and potentially provided a new insight into understanding the mechanical regulation of glucose homeostasis."
< "Q99JA4-1","RefSeq","NP_001268788.1","30183378","Cysteinyl leukotriene receptor 1 (cysLT1R) regulates osteoclast differentiation and bone resorption."
< "Q99JA4-1","RefSeq","NP_001268788.1","11932261","Determination of role in enhanced vascular permeability of mice undergoing acute inflammatory responses"
665a973
> "Q9JMB0-1","RefSeq","NP_062806.1","25586176","Data show that cGMP-dependent kinase (cGK-Ialpha) knockdown partially rescued TNF-alpha-induced decrease in 42-kDa cGMP-dependent protein kinase-anchoring protein (GKAP42) and impairment of insulin signals."
668a977
> "Q9D384-1","RefSeq","NP_083808.1","27557711","Elevated U12-intron retention has been demonstrated in all examined tissues from spinal muscular atrophy mice."
677a987,989
> "Q6P8J2-1","RefSeq","NP_081267.1","28578006","In testis tissue subjected to busulfan, increased expression of Sat2 can cause cellular injury and subsequent organ damage, which could lead to male infertility. Therefore, Sat2 may be a novel molecular target for treating busulfan-induced testicular toxicity."
> "Q6P8J2-1","RefSeq","NP_081267.1","19164485","These studies indicate that SAT2 deficient animals are protected against ischemia-reperfusion injuries (IRI) and suggest that SAT2 is an important mediator of the tissue damage in IRI."
> "Q6P8J2-1","RefSeq","NP_081267.1","17371273","Sat2 acts as a tumor promoter in the adenomaatous polyposis coli mouse (Min/+) model."
688a1001,1003
> "Q60772-1","RefSeq","NP_031697.1","29298882","Host Tumor Suppressor p18(INK4c) Functions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis. Publication Status: Online-Only"
> "Q6S5C2-1","RefSeq","NP_766117.2","19955174","Analysis of functional differences in alpha, beta, and gamma subunits of UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase"
> "Q8R3P0-1","RefSeq","NP_075602.2","18987190","Nur7( Q193X) is a nonsense mutation in the mouse aspartoacylase gene that causes spongy degeneration of the CNS."
693a1009,1011
> "Q3U3C9-1","RefSeq","NP_941073.2","16169686","Some mKIAA genes are apparently relevant to retinoic acid-induced neurite outgrowth. (mKIAA gene)"
> "P46656-1","RefSeq","NP_032022.1","28274746","Data suggest that Sf1 and c-jun interact and cooperate to activate the Fdx1 promoter in MA-10 (tumorigenic cell line) and TM3 (non-tumorigenic cell line) Leydig cells; such activation requires different regulatory elements located between -124 and -306 bp of Fdx1 promoter and involves recruitment of Sf1 to this region. (Sf1 = splicing factor 1; c-jun = proto-oncogene c-jun; Fdx1 = ferredoxin 1)"
> "P46656-1","RefSeq","NP_032022.1","16899466","Mouse MT-CYP1A1 is an extrinsic membrane protein, which exhibited high FDX1 plus FDXR-mediated N-demethylation of a number of tricyclic antidepressants, pain killers, anti-psychotics, and narcotics that are poor substrates for microsomal CYP1A1"
701a1020,1023
> "O08739-1","RefSeq","NP_033797.2","28746349","Data show that AMP deaminase 3 (Ampd3)-/-/5'-nucleotidase (CD73)-/- knockout mice are more sensitive to AMP-induced hypometabolism than mice with a single enzyme deficiency, which are more sensitive than wild type. Publication Status: Online-Only"
> "O08739-1","RefSeq","NP_033797.2","27991918","Depletion of the epigenome modifier histone deacetylase 3 (HDAC3) specifically in skeletal muscle causes severe systemic insulin resistance in mice but markedly enhances endurance and resistance to muscle fatigue, despite reducing muscle force. This is due to lower glucose utilization and greater lipid oxidation in HDAC3-depleted muscles, a fuel switch caused by the activation of anaplerotic reactions driven by Ampd3."
> "O08739-1","RefSeq","NP_033797.2","27465915","Mice carrying the mutation exhibit rapid RBC turnover, with increased erythropoiesis, dramatically shortened RBC lifespan, and signs of increased RBC senescence/eryptosis, suggesting a key role for AMPD3 in determining RBC half-life. Mice were also found to be resistant to infection with the rodent malaria Plasmodium chabaudi."
> "O08739-1","RefSeq","NP_033797.2","17384464","Along with the activation of AMPD3, ischemia-reperfusion-induced lung inflammation is associated with increased MPO activity and TNF-alpha level."
710a1033,1043
> "Q8K2V1-1","RefSeq","NP_666193.2","30132533","MiR3383p may be involved in TNFalphamediated gluconeogenesis via targeting of PP4R1 in hepatocytes."
> "Q8K2V1-1","RefSeq","NP_666193.2","27507813","LCMT-1 homozygous knock-out MEFs exhibited hyperphosphorylation of HDAC3, a reported target of the methylation-dependent PP4R1-PP4c complex. Collectively, our data suggest that LCMT-1 coordinately regulates the carboxyl methylation of PP2A-related phosphatases and, consequently, their holoenzyme assembly and function."
> "Q91Z31-1","RefSeq","NP_062423.1","30733148","Axonogenesis-associated splicing changes are governed by PTBP2."
> "Q91Z31-1","RefSeq","NP_062423.1","29045475","Ptbp2 is an essential factor in heat stress-induced sperm cell injury and non-obstructive azoospermia. Publication Status: Online-Only"
> "Q91Z31-1","RefSeq","NP_062423.1","10829067","PTBP2 was identified as a brain-expressed protein that interacts with the paraneoplastic target antigen Nova1 by yeast 2-hybrid, in vivo co-IP and co-localization in neurons. Functionally, the proteins antagonize each other in splicing assays."
> "Q9ERB5-1","RefSeq","NP_067446.1","29706500","Our data provide solid evidence for a unique gate-keeper function of MCT8 and OATP1C1 in SC activation, underscoring the importance of a finely tuned TH signaling during myogenesis."
> "Q9ERB5-1","RefSeq","NP_067446.1","25594699","The data demonstrate that OATP1c1 and MCT8 expression are regulated in a parallel manner during inflammation at the blood-brain barrier of rodents."
> "Q9ERB5-1","RefSeq","NP_067446.1","24129767","This study identified the thyroid hormone transporter OATP1C1 as the SR101-uptake transporter in hippocampus and cortex"
> "Q9ERB5-1","RefSeq","NP_067446.1","24691440","Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis."
> "Q9ERB5-1","RefSeq","NP_067446.1","18687783","OATP14 mRNA and protein are strongly enriched in mouse and rat cerebral microvessels but not in human microvessels."
> "Q9ERB5-1","RefSeq","NP_067446.1","15166123","Basolateral localization of mOatp14 in the choroid plexus in which it may also play a role in T4 uptake."
724a1058,1066
> "I7HJS2-1","RefSeq","NP_001167018.1","30632304","Tafazzin was elevated in the hearts of high-fat-diet fed mice.Increased tafazzin contributes to insulin resistance via mediating Drp-1 translocation to the mitochondria."
> "I7HJS2-1","RefSeq","NP_001167018.1","30154246","Targeting mTORC2 retards fibroblast activation and kidney fibrosis through suppressing Yap/Taz activation."
> "I7HJS2-1","RefSeq","NP_001167018.1","30055293","Findings demonstrate that TAZ-mediated remodeling of cardiolipin (CL) contributes significantly to the expansive distribution of CL molecular species in the brain, plays a key role in mitochondria respiratory activity, maintains normal cognitive function."
> "I7HJS2-1","RefSeq","NP_001167018.1","21068380","Tafazzin knockdown mice provide a mammalian model system for Barth syndrome in which the pathophysiological relationships between altered content of mitochondrial phospholipids, ultrastructural abnormalities, myocardial and mitochondrial dysfunction"
> "I7HJS2-1","RefSeq","NP_001167018.1","19114128","The data suggest that tafazzin deficiency affects cardiolipin in all mitochondria, but significant alterations of the ultrastructure, such as remodeling and aggregation of inner membranes, will only occur after specific differentiation."
> "P11862-1","RefSeq","NP_032113.1","28990109","These findings suggest that downregulated miR3425p is involved in regulating cell proliferation and cell cycles in Zmpste24/ MEFs by suppressing GAS2 in vitro."
> "P11862-1","RefSeq","NP_032113.1","27734842","GAS2 is a critical and novel regulator of tissue remodeling in the ovary during oocyte cyst breakdown and folliculogenesis Publication Status: Online-Only"
> "P11862-1","RefSeq","NP_032113.1","15817486","Gas2DN can increase the activity of calpain and induce degradation of stabilized/mutated beta-catenin"
> "Q8CG47-1","RefSeq","NP_598547.1","29043883","Study examined the expression of SMC4 in acute myeloid leukemia (AML) pediatric patients cells and normal cells and revealed that SMC4 was significantly higher than control. Utilizing SMC4 gene knockdown in the established MLL-AF9 AML mouse model study found that SMC4 knockdown inhibited AML progression by maintaining leukemia stem cells."
727a1070,1073
> "Q9R155-1","RefSeq","NP_035997.1","30146013","Study in a mouse model carrying a human WNK4 missense mutation (Q562E) previously identified in patients with pseudohypoaldosteronism type II (PHAII) demonstrated an important contribution of pendrin in renal regulation of sodium chloride, potassium and acid-base homeostasis and in the pathophysiology of PHAII and identified renal distal bicarbonate secretion as a novel mechanism of renal tubular acidosis."
> "Q9R155-1","RefSeq","NP_035997.1","29021385","Our results suggest that pendrin contributes to the maintenance of normal BP in cooperation with NCC during activation of the renin-angiotensin- aldosterone system by dietary salt restriction."
> "Q9R155-1","RefSeq","NP_035997.1","28994389","Here, the authors show that the mouse endolymphatic sac absorbs fluid in an SLC26A4-dependent fashion. Publication Status: Online-Only"
> "Q9R155-1","RefSeq","NP_035997.1","12217866","Its presence in both the apical plasma membrane and the apical intracellular vesicles of type B and non-A-non-B intercalated cells suggests that HCO secretion may be regulated by trafficking between the two membrane compartments"
739a1086,1087
> "Q80WT2-1","RefSeq","NP_796334.2","30143575","Study suggests that DMRT3/5 function with EMX2 in positioning the pallial-subpallial boundary by antagonizing the ventral homeobox transcription factor GSX2."
> "Q80WT2-1","RefSeq","NP_796334.2","28031177","Finely tuned levels of DMRT5, together with DMRT3, regulate patterning of the cerebral cortex."
741,746d1088
< "Q80U58-1","RefSeq","NP_001153691.1","30642763","A PUM2-mediated layer of post-transcriptional regulation links altered Mff translation to mitochondrial dynamics and mitophagy, thereby mediating age-related mitochondrial dysfunctions."
< "Q80U58-1","RefSeq","NP_001153691.1","29046322","These results argue for a role of Pum2 in epileptogenesis and the maintenance of epilepsy."
< "Q80U58-1","RefSeq","NP_001153691.1","28794184","Major role of Pum1 and Pum2 in hippocampal neurogenesis and function"
< "O08532-1","RefSeq","NP_001104313.1","30355732","The interaction between alpha2delta-1 and NMDARs is of high physiological relevance"
< "O08532-1","RefSeq","NP_001104313.1","16460711","Alpha(2)-delta Type 1 subunit of voltage-gated calcium channels is the major binding protein for pregabalin in the brain and spinal cord."
< "O08532-1","RefSeq","NP_001104313.1","1847144","This study of the rabbit ortholog of dihydropyridine-sensitive calcium channel alpha 2 provides N-terminal sequencing evidence of the cleavage junction of the alpha2 and delta subunits from the preprotein"
754a1097
> "Q01320-1","RefSeq","NP_035753.2","28250416","TOP2 and BAF cooperate to recruit pluripotency factors, which explains some of the instructive roles of BAF complexes."
757a1101,1103
> "P08923-1","RefSeq","NP_996825.2","22079349","In hippocampus, Ltk and Alk (anaplastic lymphoma kinase) are expressed throughout dentate gyrus, CA1, and CA3. Data suggest genetic interactions between Ltk and Alk in neurogenesis and behavioral measures (i.e., activity, anxiety, spatial memory)."
> "P08923-1","RefSeq","NP_996825.2","18854310","LAR regulates Fyn/JAK2/STAT3 and Fyn/p38 MAPK pathways involved in ROS-induced apoptosis"
> "P08923-1","RefSeq","NP_996825.2","2357970","Translation initiates from a non-AUG codon (CUG) in some Ltk transcript variants."
786a1133,1137
> "Q7TSY8-1","RefSeq","NP_950172.1","28781233","Molecular chaperone SET-assisted eviction of linker histones and Shugoshins is a fundamental step in mammalian mitotic progression."
> "Q7TSY8-1","RefSeq","NP_950172.1","28502659","By promoting proteolysis of cyclins and Cdc25B at germinal vesicle stage, APC/C associated Cdh1(APC/CCdh1) delays increase in Cdk1 activity, leading to germinal vesicle breakdown (GVBD); by moderating the rate at which Cdk1 is activated following GVBD, APC/CCdh1 creates conditions necessary for the removal of shugoshin-2 from chromosome arms by Aurora B/C kinase, an event crucial for efficient resolution of chiasmata."
> "Q7TSY8-1","RefSeq","NP_950172.1","27629923","In mouse, Sgol2a encoding shugoshin-like 2a is necessary during meiosis in both sexes to maintain the integrity of the cohesin complex that tethers sister chromatids. Human SGO2 has not previously been implicated in any disorder, but in this case of POI and perhaps others, it is a candidate for unexplained infertility."
> "Q7TSY8-1","RefSeq","NP_950172.1","18765791","SGOL2 is necessary for protecting centromeric cohesion during mammalian meiosis I. In vivo, the loss of SGOL2 promotes a premature release of the meiosis-specific REC8 cohesin complexes from anaphase I centromeres"
> "Q7TSY8-1","RefSeq","NP_950172.1","18084284","Results show that shugoshin Sgo2 is expressed in germ cells."
789,790c1140,1148
< "Q3UUJ4-1","RefSeq","NP_001239377.1","21903876","Quantitative PCR revealed significantly reduced LKB1, MO25alpha, and STRADbeta mRNA in LKB1(-/-) muscle. These findings demonstrate that the LKB1-MO25-STRAD complex is the principal AMPKK in skeletal muscle."
< "Q3UUJ4-1","RefSeq","NP_001239377.1","20424326","Aberrant nuclear accumulation of LKB1 caused by STRADalpha deficiency contributes to hyperactivation of mTORC1 signaling and disruption of neuronal lamination during corticogenesis"
---
> "P26955-1","RefSeq","NP_031806.3","30100408","This study demonstrates that induced pluripotent stem cell-derived macrophages effectively treat pulmonary alveolar proteinosis in Csf2rb-deficient mice after pulmonary transplantation."
> "Q99K51-1","RefSeq","NP_663604.1","30204862","Regulation of osteoclastogenesis and bone remodeling via the PLS3-NKRF-NFkappaB-NFATC1 axis unveils a novel possibility to counteract osteoporosis."
> "Q99K51-1","RefSeq","NP_663604.1","30188931","Of the six biomarkers, only COMP and DPP4 showed high and SPP1 moderate correlation with the spinal muscular atrophy phenotype. PLS3 overexpression neither influenced the SMN level nor the six biomarkers, supporting the hypothesis that PLS3 acts as an independent protective modifier. Publication Status: Online-Only"
> "Q99K51-1","RefSeq","NP_663604.1","28646489","Data indicate there are 6 mutations in Plastin-3 (PLS3) responsible for X-linked osteoporosis, and the mutation c.759_760insAAT (p.Ala253_Leu254insAsn) is located in exon 8."
> "Q99K51-1","RefSeq","NP_663604.1","28559444","Depletion of Pls3 transcripts in mouse embryos caused basement membrane and polarity defects in the epidermis which were secondary to the disruption of the basement membrane but had little effect on cell adhesion and differentiation. Publication Status: Online-Only"
> "Q99K51-1","RefSeq","NP_663604.1","28289706","PLS3 coadministration improves the phenotype beyond the antisense oligonucleotides, demonstrating the potential utility of combinatorial therapeutics in spinal muscular atrophy that target SMN-independent and SMN-dependent pathways. Publication Status: Online-Only"
> "P97872-1","RefSeq","NP_034362.2","28646079","Fmo5(-)(/)(-) mice have metabolic characteristics similar to those of germ-free mice, indicating that FMO5 plays a role in sensing or responding to gut bacteria. In WT mice, FMO5 is present in the mucosal epithelium of the gastrointestinal tract where it is induced in response to a high-fat diet."
> "P97872-1","RefSeq","NP_034362.2","26049045","The phenotype of a knockout mouse identifies FMO5 as a regulator of metabolic aging."
> "P97872-1","RefSeq","NP_034362.2","17721934","The functional activity of Fmo5 was determined."
792a1151,1163
> "Q2LA85-1","RefSeq","NP_001028577.2","27143430","TREM2 and TREML2 play opposite roles in microglia activation"
> "Q2LA85-1","RefSeq","NP_001028577.2","22573805","Thus, our studies identified TLT2 as an engulfment receptor for apoptotic cells."
> "Q2LA85-1","RefSeq","NP_001028577.2","21804015","TLT2 ligation enhances the neutrophil response to the formylated peptide FMLF, leading to increased reactive oxygen species production, degranulation, and chemotaxis"
> "Q2LA85-1","RefSeq","NP_001028577.2","20141543","(+) T-cell effector function, possibly by ligation of TLT-2 on tumour-infiltrating CD8(+) T cells at the local tumour site."
> "Q2LA85-1","RefSeq","NP_001028577.2","19544488","Data do not point to a role for TREML2 as a receptor for B7-H3."
> "Q2LA85-1","RefSeq","NP_001028577.2","18650384","Analysis of an interaction between B7-H3 and TLT-2 that preferentially enhances CD8(+) T cell activation Erratum:[Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14744]"
> "Q2LA85-1","RefSeq","NP_001028577.2","16670310","TLT2 may be involved in the innate immune response based on its expression profile and the fact that it is up-regulated in response to inflammation."
> "Q80W99-1","RefSeq","NP_084048.1","29371110","Data suggest that Catsper1, Catsper2, Catsper3, and Catsper4 form protein multimer with hypothetical activities of flippase and disulfide isomerase."
> "Q80W99-1","RefSeq","NP_084048.1","20586097","Hydrogen peroxide induced upregulation of catsper3 in brain."
> "Q80W99-1","RefSeq","NP_084048.1","18607386","Data show that spinal cord injury doesn't significantly change the expression of CatSpers 3."
> "Q80W99-1","RefSeq","NP_084048.1","17344468","Catsper3 and Catsper4 knockout male mice are completely infertile due to a quick loss of motility and a lack of hyperactivated motility under capacitating conditions."
> "Q80W99-1","RefSeq","NP_084048.1","16107607","CATSPER3 is a cation-channel protein and has role in acrosome reaction and male fertility"
> "Q80W99-1","RefSeq","NP_084048.1","12932298","Catsper3 has a single channel-forming domain, a pore-loop with the consensus sequence TxDxW, & a coiled-coil protein-protein interaction domain in the C-terminal tail. CatSpers 1,2,3 & 4 may interact directly or indirectly to form a functional tetramer. Publication Status: Online-Only"
793a1165,1166
> "P58659-1","RefSeq","NP_081903.1","25122090","We demonstrate that MADD-4 interacts with an EVA-1/UNC-40 co-receptor complex to attract cell extensions Publication Status: Online-Only"
> "P58659-1","RefSeq","NP_081903.1","24040182","We report that EVA1C is expressed by axons contributing to commissures, tracts and nerve pathways of the developing spinal cord and forebrain. Publication Status: Online-Only"
817,819c1190
< "Q08874-1","RefSeq","NP_001106669.1","30471646","Cardiac mast cells are dependent on Mitf expression, with loss-of-function mutation in the Mitf gene leading to near-complete lack of cardiac mast cells. Loss of a single Mitf allele is sufficient for relative mast cell deficiency."
< "Q08874-1","RefSeq","NP_001106669.1","17438132","Data show that there is physiological switching of Mitf isoforms and that the promoter context and the cell context have a combined influence on gene expression programs."
< "Q08874-1","RefSeq","NP_001106669.1","17182576","This work defines the transcriptome regulated by Mitf in mast cells and supports its role as master regulator of mast cell differentiation."
---
> "P10820-1","RefSeq","NP_035203.3","30575733","Prf1(-/-) mice with impaired cell cytotoxicity exhibit higher senescent-cell tissue burden and chronic inflammation. They suffer from multiple age-related disorders and lower survival. Publication Status: Online-Only"
823a1195
> "Q3UQU0-1","RefSeq","NP_001294970.1","30510198","Bromodomain containing 9 (BRD9) regulates transcription for the maintenance of embryonic stem cell (ESC). Publication Status: Online-Only"
831a1204
> "Q8BTZ5-1","RefSeq","NP_780343.1","25542822","MiR-451 was specifically up-regulated during the implantation period, and it may play a major role in embryo implantation by targeting Ankrd46."
832a1206,1211
> "P52479-1","RefSeq","NP_033488.1","30898698","Results show that Mirt2-mediated upregulation of USP10 protein expression can be reversed by silencing USP10 in the hepatocytes. USP10 inhibition could abolish Mirt2 overexpression-induced suppression of glucose production and lipogenesis in hepatocytes."
> "P52479-1","RefSeq","NP_033488.1","29698567","USP10 inhibits hepatic steatosis, insulin resistance, and inflammation through Sirt6."
> "P52479-1","RefSeq","NP_033488.1","28852924","USP10 directly interacted with and stabilized PTEN via deubiquitination."
> "P52479-1","RefSeq","NP_033488.1","27974222","USP10 is an essential deubiquitinase in hematopoiesis and functions by inhibiting apoptosis of hematopoietic stem cells including long-term HSCs."
> "P52479-1","RefSeq","NP_033488.1","26393420","Thus, modulating the levels of both Huwe1 and USP10 appears to fine-tune the requisite degradation of TBP during myogenesis. Publication Status: Online-Only"
> "P52479-1","RefSeq","NP_033488.1","18632802","Vasopressin-induced Usp10 deubiquitylates and stabilizes endogenous SNX3 and consequently promotes cell surface expression of ENaC in kidney"
834a1214,1215
> "Q8C5L3-1","RefSeq","NP_082358.2","24200330","These data have uncovered a novel role of core components of the Ccr4-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells."
> "Q8C5L3-1","RefSeq","NP_082358.2","22367759","Cnot1, Cnot2, and Cnot3 represent a novel component of the core self-renewal and pluripotency circuitry conserved in mouse and human ESCs."
840a1222,1223
> "Q921L8-1","RefSeq","NP_659157.1","15486088","Homology models of several ppGaNTase isoforms predict dramatically different surface chemistries consistent with isoform-selective acceptor substrate recognition"
> "Q921L8-1","RefSeq","NP_659157.1","12651884","Real-time polymerase chain reaction using the Taqman method to determine the expression of ppGaNTase isoforms in mouse tissues. In contrast to the general pattern, testis, sublingual gland, and colon exhibited distinctive profiles of isoform expression"
846c1229,1231
< "Q32MG2-1","RefSeq","NP_001157611.1","12204287","Immunogold electron microscopy revealed that the protein is restricted, from its first detectable appearance, to a unique spermatid organelle called the 'flower-like structure'"
---
> "Q91YY5-1","RefSeq","NP_570931.1","21084765","Immunoreactivity to anti-Oatp1a antibody was colocalized with PDZK1 in the small intestine of wild-type mice, whereas apical localization of Oatp1a protein was reduced in pdzk1(-/-) mice. PDZK1 appears to act as an adaptor for Oatp1a[Oatp1a]"
> "Q09M02-1","RefSeq","NP_777274.1","28128286","Nna1 and CCP5 do not work coordinately in the same pathway in either the nervous system or spermatogenesis. Publication Status: Online-Only"
> "Q09M02-1","RefSeq","NP_777274.1","24022482","CCP5 functions as a dual-functional deglutamylase cleaving both alpha- and gamma-linked glutamate from tubulin."
859,860d1243
< "P59055-1","RefSeq","NP_700458.3","23076708","CpG methylation converses with histone modifications in an opposing sense of regulating Mbu-1 expression"
< "P59055-1","RefSeq","NP_700458.3","17433858","The mbu-1 gene was only expressed in the brain and spinal cord during the embryonic stages, and throughout all regions of the adult brain, showing higher levels in the hippocampus and hypothalamus"
863a1247,1250
> "Q8BYH8-1","RefSeq","NP_796198.1","29665362","A loosened chromatin structure, which is mediated by Chd9, is a prerequisite for the acquisition of totipotency after fertilization."
> "Q8BYH8-1","RefSeq","NP_796198.1","25689118","Our new findings support the role for CHD9 in chromatin regulation and association with rDNA genes, in addition to its already known function in transcription control of tissue specific genes"
> "Q8BYH8-1","RefSeq","NP_796198.1","16523501","CReMM is a chromodomain helicase-DNA-binding protein expressed by osteoprogenitors[CReMM]"
> "Q8BYH8-1","RefSeq","NP_796198.1","16419031","Results imply that in osteogenic cells CReMM/CHD9 selectively interacts with promoters activated in the tissue at the appropriate time of embryonic development."
887a1275,1278
> "Q07235-1","RefSeq","NP_033281.1","30254103","These data demonstrate that prevention of thrombin signaling by PN-1 constitutes an important endogenous mechanism of protection against lung fibrosis and associated mortality."
> "Q07235-1","RefSeq","NP_033281.1","28706437","PN-1 and PEDF share structural and functional features, and expression patterns in the retina. Publication Status: Online-Only"
> "Q07235-1","RefSeq","NP_033281.1","27793045","SerpinE2 is required in the extracellular milieu of breast tumors where it acts in multiple ways to regulate tumor matrix deposition, thereby controlling tumor cell dissemination."
> "Q07235-1","RefSeq","NP_033281.1","27059719","These data uncover a novel mechanism whereby loss of serine protease inhibition leads to lung lymphocyte accumulation."
889a1281,1282
> "Q8K2P6-1","RefSeq","NP_849247.3","21238580","Findings together provide novel evidence that mitochondria are the direct hypoxic targets in PASMCs, in which Rieske iron-sulfur protein in complex III may serve as an essential, primary molecule that mediates the hypoxic ROS generation"
> "Q8K2P6-1","RefSeq","NP_849247.3","18703841","Mouse Rieske-type ferredoxin was shown to be capable of accepting electrons from both eukaryotic and prokaryotic oxidoreductases, although it was unable to serve as an electron donor for a bacterial monooxygenase complex."
897c1290,1291
< "Q8BYW1-1","RefSeq","NP_001032816.1","27566826","Using Arhgap25-deficient mice, it identified ARHGAP25 as a relevant negative regulator of leukocyte transendothelial migration."
---
> "Q9JL27-1","RefSeq","NP_061364.2","28056490","Fut2 gene expression is responsible for disease progression in mice with primary sclerosing cholangitis."
> "Q9JL27-1","RefSeq","NP_061364.2","27161092","Results indicate that the fucosyltransferase 2 (FUT2) determines the O-glycosylation pattern of mucin-5AC (Muc5ac). Publication Status: Online-Only"
900a1295
> "P0C027-1","RefSeq","NP_067406.2","12689335","High levels are expressed primarily in brain"
921a1317
> "Q80TL4-1","RefSeq","NP_766278.1","27145804","GINIP is predominantly expressed by small nonpeptidergic nociceptive neurons and that nerve injury triggers loss of GINIP expression. Publication Status: Online-Only"
925a1322,1323
> "Q9Z1M7-1","RefSeq","NP_034817.1","29915039","These findings indicate that the fine-tuning of AMPA-R trafficking by LARGE at the Golgi is critical for hippocampus-dependent memory in the brain."
> "Q9Z1M7-1","RefSeq","NP_034817.1","27467128","Data suggest LARGE overexpression may only be deleterious under a forced regenerative context, such as that resulting from a reduction in FKRP: in the absence of such a defect we show that systemic expression of LARGE can indeed act therapeutically, and that even dramatic LARGE overexpression is well-tolerated in heart and skeletal muscle Publication Status: Online-Only"
934a1333
> "P52927-1","RefSeq","NP_034571.1","28963864","MiR-495 inhibits new bone regeneration via targeting high mobility group AT-Hook 2 (HMGA2). Publication Status: Online-Only"
956c1355,1356
< "P97931-1","RefSeq","NP_001035781.1","28775312","We showed that SMUG1 efficiently prevent genomic uracil accumulation, even in the presence of UNG, and identified mutational signatures associated with combined UNG and SMUG1 deficiency. Publication Status: Online-Only"
---
> "P86049-1","RefSeq","NP_001139800.1","28212427","Rbm46 regulates mouse embryonic stem cell differentiation through down-regulation of beta-Catenin.Rbm46 regulates mouse embryonic stem cell differentiation by targeting beta-Catenin mRNA for degradation. Publication Status: Online-Only"
> "P86049-1","RefSeq","NP_001139800.1","25397698","Rbm46 directly binds to and stabilizes Cdx2 mRNA in early mouse embryos."
976,979d1375
< "Q64702-1","RefSeq","NP_035625.2","28972102","Aurora A and Plk4 are rate-limiting factors contributing to microtubule growth as the acentriolar oocyte resumes meiosis."
< "Q64702-1","RefSeq","NP_035625.2","26595384","That aneuploidy induced by transient centrosome amplification can accelerate tumorigenesis in p53-deficient cells"
< "Q64702-1","RefSeq","NP_035625.2","26439168","Transient knockdown of KLF14 is sufficient to induce Plk4-directed centrosome amplification. Publication Status: Online-Only"
< "Q64702-1","RefSeq","NP_035625.2","12352953","2.0 A crystal structure of a novel domain composed of the polo box motif of murine Sak"
981a1378,1381
> "Q80SZ6-1","RefSeq","NP_570958.1","18063567","Results suggest that NXF7 plays a role in sorting, transport and/or storage of mRNAs through interactions with hnRNP A3."
> "Q80SZ6-1","RefSeq","NP_570958.1","16014633","NXF7 colocalizes with Staufen1, polyA, and 28 S RNA within mobile cytoplasmic granules in neurites and in extended cytoplasmic processes of non-neuronal cells"
> "Q80SZ6-1","RefSeq","NP_570958.1","16027110","NXF7 localizes exclusively to cytoplasmic granules and lacks mRNA export activity. Publication Status: Online-Only"
> "O35448-1","RefSeq","NP_062314.1","14528005","PPT2 deficiency in mice causes an unusual form of neuronal ceroid lipofuscinosis with striking visceral manifestations. All PPT2-deficient mice displayed a neurodegenerative phenotype with spasticity and ataxia by 15 mo."
990a1391,1396
> "Q2TV84-1","RefSeq","NP_061222.3","29854741","TRPM1 and mGluR6 are both essential components in the signaling pathway. Publication Status: Online-Only"
> "Q2TV84-1","RefSeq","NP_061222.3","28899920","Results suggest that TRPM1 channel opening is essential for rod bipolar pathway establishment in development"
> "Q2TV84-1","RefSeq","NP_061222.3","19966281","These results demonstrate that TRPM1-L is a component of the ON bipolar cell (BC) transduction channel downstream of mGluR6 in ON BCs."
> "Q9Z2W0-1","RefSeq","NP_058574.3","29122955","Study shows that in the absence of aspartyl aminopeptidase (DNPEP), the kidney lysates retain their ability to cleave STE20/SPS1-related proline/alanine-rich kinase(SPAK), indicating that DNPEP might have been misidentified as the protease behind the kidney lysate activity, or that the aspartyl aminopeptidase might not be the only protease cleaving SPAK in kidney."
> "Q9Z2W0-1","RefSeq","NP_058574.3","21576357","Results demonstrate that Mir140 is essential for normal endochondral bone development and suggest that the reduced BMP signaling caused by Dnpep upregulation plays a causal role in the skeletal defects of Mir140-null mice."
> "Q9Z2W0-1","RefSeq","NP_058574.3","11903661","Dietary fatty acids affect activity in mouse testis"
993a1400,1405
> "Q9Z0L0-1","RefSeq","NP_035757.2","29624737","The binding of osteoclast-derived CTHRC1 to WAIF1 in stromal cells activates PKCdelta-ERK osteoblastogenic signaling."
> "Q9Z0L0-1","RefSeq","NP_035757.2","22956548","The surface expression of 5T4 marks the use of the CXCR4 rather than the CXCR7 receptor, with distinct consequences for CXCL12 exposure."
> "Q9Z0L0-1","RefSeq","NP_035757.2","16506198","Because 5T4 is known to interact with actin cytoskeleton, these observations suggest that 5T4 is involved in the formation or maintenance of strata-specific dendritic ramification or synaptic connection of subsets of local interneurons."
> "Q9Z0L0-1","RefSeq","NP_035757.2","15977177","A limited expression profile of 5T4 may contribute to the migration of actively cycling, undifferentiated epithelial progenitor cells during embryogenesis"
> "Q9Z0L0-1","RefSeq","NP_035757.2","14576347","5T4 glycoprotein expression is associated with early differentiative events of embryonic stem cells"
> "Q9Z0L0-1","RefSeq","NP_035757.2","11903056","Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen"
997a1410,1412
> "Q9D032-1","RefSeq","NP_940840.1","27236334","Ssbp3 induces differentiation of mouse embryonic stem cells into trophoblast-like cells. Publication Status: Online-Only"
> "Q9D032-1","RefSeq","NP_940840.1","26495868","SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic beta-Cell Target Genes"
> "Q9D032-1","RefSeq","NP_940840.1","15857913","Ssdp1 regulates the development of late head organizer tissues and body growth by functioning as an essential activator component of a Lim1 complex through interaction with Ldb1."
1000a1416,1419
> "Q9CXG9-1","RefSeq","NP_082992.1","31089138","In B16 mouse melanoma model miR-155 enhances Polycomb repressor complex 2 (PRC2) activity indirectly by promoting the expression of the PRC2-associated factor Phf19 through downregulation of the Akt inhibitor, Ship1. Phf19 orchestrates a transcriptional program extensively shared with miR-155 to restrain T cell senescence and sustain CD8+ T cell antitumor responses. Publication Status: Online-Only"
> "Q91VA3-1","RefSeq","NP_570960.2","20686710","Gastrointestinal-tract-specific calpains 8 and 9 formed a complex we termed 'G-calpain,' in which both were essential for gastric mucosal defense Publication Status: Online-Only"
> "Q91VA3-1","RefSeq","NP_570960.2","17646163","NCL-2/calpain 8 is active without calpain regulatory subunit and oligomerizes through C2-like domains"
> "Q91VA3-1","RefSeq","NP_570960.2","16476741","NCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP"
1004a1424,1427
> "Q8BWF2-1","RefSeq","NP_778200.1","29382851","Gimap5 is a critical inhibitor of GSK3-beta in the CD4+ T cells. Publication Status: Online-Only"
> "Q8BWF2-1","RefSeq","NP_778200.1","27023180","Functional Gimap5 is required for optimal signaling through TCR and IL-7R in T cells. Publication Status: Online-Only"
> "Q8BWF2-1","RefSeq","NP_778200.1","25944983","Gimap5 has a role in maintaining peripheral tolerance and T cell homeostasis in the gut [review] Review article"
> "Q8BWF2-1","RefSeq","NP_778200.1","18796632","Mouse gimap5 is necessary for the survival of peripheral T cells, NK/NKT-cell development, and the maintenance of normal liver function"
1008a1432
> "Q61136-1","RefSeq","NP_038858.2","12077342","Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes."
1019a1444,1447
> "O88623-1","RefSeq","NP_932760.2","29490279","These findings have characterized an essential role of USP2a as a potential target for treatment of metastatic cancers."
> "O88623-1","RefSeq","NP_932760.2","28586165","3,3'-Diindolylmethane directly inhibits USP2 deubiquitinase activity in 3T3-L1 pre-adipocytes."
> "O88623-1","RefSeq","NP_932760.2","26643174","Usp2 is required for the PTH1-34-induced proliferation of osteoblasts"
> "O88623-1","RefSeq","NP_932760.2","26756164","Usp2 is a clock output effector related to bodily Ca2+ homeostasis, a feature that is conserved across evolution. Publication Status: Online-Only"
1035a1464,1466
> "O88843-1","RefSeq","NP_034080.1","25857265","The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd"
> "O88843-1","RefSeq","NP_034080.1","24958727","Define a novel function for CRADD in endothelial cells as an inducible suppressor of BCL10, a key mediator of responses to proinflammatory agonists"
> "O88843-1","RefSeq","NP_034080.1","12558660","Overexpression of Raidd cDNA in 3T3L1 cells inhibited differentiation of the preadipocytes."
1037a1469
> "Q80SZ7-1","RefSeq","NP_034448.2","24599258","Targeted disruption of the mouse Gng5 gene encoding the gamma5 subtype produces embryonic lethality associated with severe head and heart defects. Publication Status: Online-Only"
1046a1479,1486
> "Q7TQ33-1","RefSeq","NP_848730.2","28479601","These findings from the K113S variant provide not only a possible explanation for the B7-DC-triggered contradictory effects on T-cell responses, but also a novel approach to investigate the B7-DC/PD-1/RGMb axis."
> "Q7TQ33-1","RefSeq","NP_848730.2","29382757","Specific knockout of Rgmb in tubular cells increased MLKL expression at the apical membrane of proximal tubular cells and induced more tubular cell death and more severe renal dysfunction compared with wild-type mice."
> "Q7TQ33-1","RefSeq","NP_848730.2","27575743","These results reveal RGMb as a novel regulator for Autosomal dominant polycystic kidney disease by promoting renal tubule branching and regulating BMP signaling pathway."
> "Q7TQ33-1","RefSeq","NP_848730.2","27545491","Study focused on the RGMa and RGMb expression in cerebral cortex and hippocampus of newborn mice with maternal lead exposure. RGMa and RGMb expression in hippocampus were upregulated in lead exposed groups, and the RGMa and RGMb expression in cerebral cortex were also higher."
> "Q7TQ33-1","RefSeq","NP_848730.2","27143755","The results indicate that RGMB-neogenin-mediated cell-cell interactions between newly born neurons and progenitor cells control the ratio of glia and neurons produced in the developing olfactory epithelium."
> "Q7TQ33-1","RefSeq","NP_848730.2","15671031","The direct interaction of DRAGON with bone morphogenetic protein (BMP) ligands and receptors indicates that it is a BMP co-receptor that potentiates BMP signaling."
> "Q7TQ33-1","RefSeq","NP_848730.2","14985445","A gene with promoter binding to the DNA binding domain of DRG11; encodes a conserved developmentally regulated membrane-associated glycosyl-phosphatidylinositol-anchored protein which promotes dorsal root ganglion neuron adhesion."
> "Q7TQ33-1","RefSeq","NP_848730.2","14678836","Predominantly expressed in developing neuron."
1052a1493,1502
> "P63089-1","RefSeq","NP_032999.1","30643194","A new oncofetal lncRNA Ptn-dt is identified."
> "P63089-1","RefSeq","NP_032999.1","30497772","Adult hippocampal neural stem cells continuously supply pleiotrophin factor to newborn neurons."
> "P63089-1","RefSeq","NP_032999.1","30327824","Results reveal for the first time that pleiotrophin is a key player in preserving insulin sensitivity, driving the dynamics of adipose tissue lipid turnover and plasticity, and regulating energy metabolism and thermogenesis."
> "P63089-1","RefSeq","NP_032999.1","30100167","The Pleiotrophin (PTN) expression is increased in bone marrow endothelial cells (BMECs), and PTN(+) ECs are more frequent in the niche."
> "Q99LI5-1","RefSeq","NP_808311.1","29941555","These observations suggest that ZNF281 is a controller of neuronal differentiation that should be evaluated as a prognostic marker in neuroblastoma."
> "Q99LI5-1","RefSeq","NP_808311.1","29036642","An important role of Zfp281 in restricting the expression of F type of young L1s in mouse embryonic stem cells."
> "Q99LI5-1","RefSeq","NP_808311.1","29168693","By characterizing Zfp281 mutant phenotypes and identifying Zfp281 gene targets and protein partners in developing embryos and cultured pluripotent stem cells, the authors establish critical roles for Zfp281 in activating components of the Nodal signaling pathway and lineage-specific genes. Publication Status: Online-Only"
> "Q99LI5-1","RefSeq","NP_808311.1","28180295","AFF3 is associated with the Kruppel-like zinc finger protein ZFP281 in embryonic stem (ES) cells. ZFP281 recruits AFF3 to the Meg3 enhancer within the imprinted Dlk1-Dio3 locus, thus regulating the allele-specific expression of the Meg3 polycistron."
> "Q99LI5-1","RefSeq","NP_808311.1","27345836","Zfp281 interacts with Tet1, but not Tet2, and its direct transcriptional target, miR-302/367, to negatively regulate Tet2 expression to establish and maintain primed pluripotency."
> "Q99LI5-1","RefSeq","NP_808311.1","18757296","Zfp281 plays bifunctional roles in regulating gene expression within the network."
1062a1513,1520
> "P56404-1","RefSeq","NP_031500.1","27256569","AQP8 silencing impairs H2O2 entry into I.29micro+ B lymphoma cells.  AQP8 can act as an efficient H2O2 channel also in cells of the B lineage."
> "P56404-1","RefSeq","NP_031500.1","25160756","Rotavirus diarrhea is associated with the downregulation of AQP1, -4, and -8 expression."
> "Q8K211-1","RefSeq","NP_780299.2","28507097","Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2"
> "Q8K211-1","RefSeq","NP_780299.2","27143361","Studies identify a new processing event and the key protease that cleaves the Ctr1 metal-binding ectodomain, which functions to regulate cellular Cu(+) and cisplatin acquisition"
> "Q9WTU6-1","RefSeq","NP_997575.2","29950132","The role of MAPK8/9 in autophagy may be context-dependent and more complex than previously considered."
> "Q8C726-1","RefSeq","NP_766206.1","22678064","Btbd9 mutant mice had motor restlessness including increased total activity, voluntary activity, and wake time and arousals during the rest phase mimicking restless leg syndrome."
> "Q8C726-1","RefSeq","NP_766206.1","22536397","Btbd9 is naturally expressed in the hippocampus of mice and is involved in regulating synaptic plasticity and memory."
> "Q8C726-1","RefSeq","NP_766206.1","18363860","In a homologous region in mouse, an area containing btbd9 was also identified as being related to iron homeostasis Review article"
1077c1535,1544
< "Q9ERD6-1","RefSeq","NP_001153437.1","17462626","RalGPS2 was characterized."
---
> "Q61990-1","RefSeq","NP_035172.2","29866654","Embryos lacking the KH domain poly(C) binding protein, Pcbp2, are selectively deficient in the definitive erythroid lineage. Compared to wild-type controls, transcript splicing analysis of the Pcbp2(-/-) embryonic liver reveals accentuated exclusion of an exon (exon 6) that encodes a highly conserved transcriptional control segment of the hematopoietic master regulator, Runx1. Publication Status: Online-Only"
> "Q61990-1","RefSeq","NP_035172.2","29422543","These findings suggest that Hr mRNA expression is regulated at the post-transcriptional level via IRES-mediated translation control through interaction with PCPB2, but not in MUHH. Publication Status: Online-Only"
> "Q61990-1","RefSeq","NP_035172.2","27215387","Study determined that PCBP2 specifically associates with components of this kinase cascade and regulates the activities of its downstream transcriptional coactivators. Publication Status: Online-Only"
> "Q61990-1","RefSeq","NP_035172.2","26907686","Data suggest that PCBP2 regulates p73 expression via mRNA stability and p73-dependent biological function in ROS production and cellular senescence."
> "Q6P1F6-1","RefSeq","NP_082308.1","26868295","Data suggest IGT10 mice, diabetes type 2 model, exhibit 2 genetic defects: haploinsufficiency (heterozygosity for null allele) of insulin receptor (Insr); splice-site mutation in protein phosphatase 2 regulatory subunit B alpha (Ppp2r2a). Inheritance of either allele results in insulin resistance but not overt diabetes. Double heterozygosity leads to insulin resistance and diabetes type 2 without increase in body weight."
> "Q6P1F6-1","RefSeq","NP_082308.1","26310906","Concurrent mTORC1 inactivation and PP2A-B55alpha stimulation fuel ULK1-dependent autophagy. Publication Status: Online-Only"
> "Q6P1F6-1","RefSeq","NP_082308.1","24390425","FBXL16 negatively regulates the activity of B55alpha-PP2A to modulate the genesis of FLK1+ progenitor cells."
> "Q6P1F6-1","RefSeq","NP_082308.1","24433183","Ppp2r2a is required for Connexin-43 dephosphorlyation during epidermal barrier acquisition"
> "Q6P1F6-1","RefSeq","NP_082308.1","18432318","PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed. Publication Status: Online-Only"
> "Q6P1F6-1","RefSeq","NP_082308.1","18042541","That B55alpha-dependent targeting of the PP2A holoenzyme to Akt selectively regulates Akt phosphorylation at Thr-308 to regulate cell proliferation and survival."
1080,1082d1546
< "Q5UAK0-3","RefSeq","NP_001034170.1","26938916","Biochemical analysis of the BAHD1-associated multiprotein complex identifies MIER proteins as novel partners of BAHD1 and suggests that BAHD1-MIER interaction forms a hub for histone deacetylases and methyltransferases Publication Status: Online-Only"
< "Q5UAK0-3","RefSeq","NP_001034170.1","17622490","This study represents the first immunohistochemical analysis of MI-ER1alpha expression in mammals."
< "Q5UAK0-3","RefSeq","NP_001034170.1","16147882","Characterization of the mouse ortholog of mi-er1 Erratum:[DNA Seq. 2005 Oct;16(5):402]"
1087d1550
< "Q6RFH4-1","RefSeq","NP_001152769.1","15482850","Assays identified a non-consensus binding site for Sp factors near sites of transcriptional initiation. The site binds Spl and Sp3 in nuclear extracts."
1103c1566,1567
< "Q8CC21-1","RefSeq","NP_082636.3","28673544","UQCRFS1 produces N-terminal polypeptides, which remain bound to holocomplex III. We show that, in normal conditions, these UQCRFS1 fragments are rapidly removed, but when TTC19 is absent they accumulate within complex III, causing its structural and functional impairment."
---
> "Q91VD9-1","RefSeq","NP_663493.2","23419200","The transition of mitochondrial complex I into the D-form in the absence of oxygen may represent a key event in promoting cardiac injury during I/R."
> "Q91VD9-1","RefSeq","NP_663493.2","23788428","Lysosomal membrane permeability induced by TNFalpha plus cycloheximide, the release of lysosomal cathepsins and reactive oxygen species formation require the caspase-3-mediated cleavage of the p75 NDUFS1 subunit of respiratory complex I."
1105a1570
> "Q8BK26-1","RefSeq","NP_775577.2","25970626","FBXO44-mediated degradation of RGS2 protein uniquely depends on a Cul4B/DDB1 complex. Publication Status: Online-Only"
1109a1575,1578
> "O54784-1","RefSeq","NP_031854.1","26117336","DAPK3 plays a central role in preventing miR-17/miR-20a depletion-induced genome instability and in miR-17/miR-20a overexpression-triggered tumor formation."
> "O54784-1","RefSeq","NP_031854.1","25304685","Cellular and mouse modeling studies show that DAPK3 is a tumor suppressor gene and is important in early development."
> "O54784-1","RefSeq","NP_031854.1","20854903","The C-terminal domain (NLS2 motif)of ZIPK of murine is nonfunctional for transport."
> "O54784-1","RefSeq","NP_031854.1","20038585","ZIPK may act as a cardiac RLC kinase and thereby affect contractility."
1120a1590,1602
> "Q8CJH3-1","RefSeq","NP_766363.2","28624895","These results demonstrate a novel physiological function for sema4D/plxnB1 signaling in retinal pigment epithelium phagocytosis."
> "Q8CJH3-1","RefSeq","NP_766363.2","28635959","Plexin-B1 coordinates cell repolarization through RhoA-ROCK-mediated redistribution of Plexin-B1. Publication Status: Online-Only"
> "Q8CJH3-1","RefSeq","NP_766363.2","12196628","LARG plays a critical role in plexin-B1 signaling to stimulate Rho activation and cytoskeletal reorganization."
> "Q8CJH3-1","RefSeq","NP_766363.2","12198496","Binding of Sema 4D to Plexin B1 stimulates the tyrosine kinase activity of Met"
> "P28301-1","RefSeq","NP_034858.2","30890638","The copper transporter ATP7A is necessary for the activity of LOX and LOXL enzymes. Silencing of ATP7A inhibited LOX activity in the 4T1 mammary carcinoma cell line."
> "P28301-1","RefSeq","NP_034858.2","15277520","Lysyl oxidase functions to inhibit ras-dependent cell transformation"
> "Q80U62-1","RefSeq","NP_766203.1","30783089","Rubicon role in aging and autophagy. Publication Status: Online-Only"
> "Q80U62-1","RefSeq","NP_766203.1","28933590","Silencing Rubcn, preventing EGFR activity or directly inducing autophagy in retinal pigment epithelial cells by starvation inhibits phagocytic degradation of photoreceptor outer segments."
> "Q80U62-1","RefSeq","NP_766203.1","19270696","Two Beclin 1 associated proteins, Atg14L and Rubicon, were identified."
> "Q80U62-1","RefSeq","NP_766203.1","19270693","Beclin 1 and its binding proteins orchestrate the precise function of the class III PI(3)K in regulating autophagy at multiple steps."
> "Q8CGM1-1","RefSeq","NP_775094.2","28894906","Surface expression of Bai2 R619W is markedly reduced relative to wild-type Bai2."
> "Q8CGM1-1","RefSeq","NP_775094.2","20367554","BAI2 is a functional GPCR regulated by proteolytic processing and activates the NFAT pathway"
> "Q8CGM1-1","RefSeq","NP_775094.2","16412436","Results point out that brain-specific angiogenesis inhibitor 2 controls VEGF transcription through GA-binding protein under normal conditions and cerebral ischemia."
1121a1604
> "Q920B0-1","RefSeq","NP_660130.2","29947801","His study reveals a critical role of FRMD4B in maintaining ELM integrity and in rescuing morphological abnormalities of the outer nuclear layer in photoreceptor dysplasia."
1126a1610,1612
> "P24161-1","RefSeq","NP_112439.1","30356906","Study findings underline the important roles of p38 and STAT3 in the regulation of PD-L1 expression and prove that IFNalpha induces STAT3/p38-mediated expression of PD-L1 and thereby a reduced stimulatory ability of dendritic cells. Publication Status: Online-Only"
> "P24161-1","RefSeq","NP_112439.1","28733484","ITAM sequence diversity is required for optimal TCR signal transduction and subsequent T cell maturation"
> "P70378-1","RefSeq","NP_034328.1","29852165","Endothelial miR-342-3p expression was significantly compromised in T2DM organisms and this inhibition powerfully blocked vasculogenesis in vivo by repressing endothelial proliferation and migration. From a mechanistic standpoint, miR-342-3p promoted the transactivation of fibroblast growth factor 11 (FGF11) by directly targeting its 3' untranslated regions (3'UTRs)."
1132,1134d1617
< "Q9R0L1-1","RefSeq","NP_001242971.1","30316871","During lens development, phosphorylation of HSF4/S299 is downregulated in P3 lens and upregulated in P7 and P14 lens. However, in 2 months old lens, both phosphorylation of HSF4/S299 and total HSF4 protein are decreased."
< "Q9R0L1-1","RefSeq","NP_001242971.1","27586257","A novel molecular mechanism of HSF4 in regulating lens epithelial cell homeostasis"
< "Q9R0L1-1","RefSeq","NP_001242971.1","15483628","Data reveal the lens-specific role of heat shock transcription factor 4 (HSF4), and indicate that HSF1 and HSF4 are involved in regulating expression of growth factor genes."
1139,1140d1621
< "O88509-1","RefSeq","NP_001003961.2","30468428","These genome-wide data combined with ultra-deep locus-specific bisulfite sequencing suggest a distributive activity of ectopically expressed Dnmt3b that leads to discordant CpG island hypermethylation and provides new insights for interpreting the cancer methylome. Publication Status: Online-Only"
< "O88509-1","RefSeq","NP_001003961.2","21666347","Dnmt3bDelta6 could induce a hypomethylation status especially in in vitro manipulated embryos."
1145a1627
> "P58771-1","RefSeq","NP_077745.2","30567734","Tropomyosin pseudo-phosphorylation results in dilated cardiomyopathy."
1147c1629,1639
< "Q9JMD0-1","RefSeq","NP_001123641.1","27177335","Data show that Zfp207 binds to Bub3 to form a complex and maintains its protein level in oocytes, and that overexpression of Bub3 is able to partially rescue the occurrence of aneuploid eggs in Zfp207-depleted oocytes."
---
> "Q8R361-1","RefSeq","NP_803417.3","26515129","The ability of insulin to increase the appearance of Rip11 at the cell surface involves an inhibition of Rip11 internalisation from the plasma membrane"
> "Q8R361-1","RefSeq","NP_803417.3","25972173","The results of this study suggest a requirement for Rab11Fip5, and presumably Rab11, during Hippocampal Long-Term Depression."
> "Q8R361-1","RefSeq","NP_803417.3","21149599","Delivery of Rab11-containing membrane stores effects broad and functional pseudopods during FcgammaR-mediated phagocytosis in mutant cultures of kinesin 5B-expressing cells."
> "Q8R361-1","RefSeq","NP_803417.3","18003705","Rip11 is a Rab11- and AS160-RabGAP-binding protein required for insulin-stimulatd glucose uptake in adipocytes."
> "Q9BCZ4-1","RefSeq","NP_077759.3","30146262","It has been proposed that SelS promoted cell survival through the IRE1a-XBP1 signaling pathway."
> "Q9BCZ4-1","RefSeq","NP_077759.3","29668323","Seps1 is a novel regulator of contractile function and cellular stress responses in fast-twitch muscles."
> "Q9BCZ4-1","RefSeq","NP_077759.3","29805311","Findings suggest that SelS protects endothelial cells against TNF-alpha-induced dysfunction by inhibiting the activation of p38 MAPK and NF-kappaB pathways and implicates it as a possible modulator of vascular inflammatory diseases. Publication Status: Online-Only"
> "Q9BCZ4-1","RefSeq","NP_077759.3","30537728","These results suggest that VIMP may function as a novel regulator to modulate beta-cell survival, proliferation, cell cycle, unfolded protein response and insulin secretion in MIN6 cells. VIMP knockdown (KD) decreases cell proliferation and G1 cell cycle arrest."
> "Q9BCZ4-1","RefSeq","NP_077759.3","18498015","We found that suppression of SEPS1 by small interfering RNA severely increases astrocyte injure caused by OGD, suggesting that selenoprotein S protects astrocytes against ischemia."
> "Q9BCZ4-1","RefSeq","NP_077759.3","17210132","These findings suggest that SEPS1 could be a new ER stress-dependent survival factor that protects macrophage against ER stress-induced cellular dysfunction."
> "Q8C255-1","RefSeq","NP_795887.2","12738806","Cloning and characterization of membrane-bound dipeptidase-2 and membrane-bound dipeptidase-3"
1150a1643,1647
> "Q3URD3-1","RefSeq","NP_114397.3","22180652","These data demonstrate that SLMAP is a regulator of E-C coupling at the level of the SR and its perturbation results in progressive deterioration of cardiac electrophysiology and function."
> "Q3URD3-1","RefSeq","NP_114397.3","21785580","SLMAP may be an important regulator of glucose uptake or involved in GLUT-4 fusion/translocation into the plasma membrane of mouse abdominal adipose tissue; changes in SLMAP expression are linked to hyperglycemia and diabetes."
> "Q3V0B4-1","RefSeq","NP_001034584.1","17971504","Ccdc108 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
> "Q8CAE2-1","RefSeq","NP_079999.2","29703750","Methylation substrates in mouse spermatogonial stem cells and the substrate-recognition mechanism of mammalian Hen1"
> "Q8CAE2-1","RefSeq","NP_079999.2","26496356","DNA damage and a catastrophic deregulation of the haploid germ cell gene expression. Collectively these results define a critical role for HENMT1 and piRNAs in the maintenance of TE repression in adult germ cells and setting the spermatogenic program. Erratum:[PLoS Genet. 2015 Dec;11(12):e1005782. PMID: 26714033] Publication Status: Online-Only"
1173a1671
> "D0QMC3-1","RefSeq","NP_001164324.1","19654412","Mndal acts as a tumor suppressor and displays haploinsufficiency"
1187a1686,1688
> "P97459-1","RefSeq","NP_032744.1","28499489","Study provides a clear, unbiased view of the full spectrum of genes regulated by NPAS1 and NPAS3 and shows that these transcription factors are master regulators of neuropsychiatric function. These findings expose the molecular pathophysiology of NPAS1/3 mutations and provide a striking example of the shared, combinatorial nature of molecular pathways that underlie diagnostically distinct neuropsychiatric conditions."
> "P97459-1","RefSeq","NP_032744.1","26311767","Npas1-expressing neurons and parvalbumin-expressing neurons are two distinct functional classes of globus pallidus neurons."
> "P97459-1","RefSeq","NP_032744.1","15347806","A regulatory program controlled in inhibitory interneurons by the NPAS1 and NPAS3 transcription factors may be either substantively or tangentially relevant to psychosis"
1192a1694
> "Q9D142-1","RefSeq","NP_079675.1","19896456","Nudt14 catalyzed the conversion of [beta-32P]UDP-glucose to [32P]glucose-1-P and UMP, confirming that it hydrolyzed the pyrophosphate of the nucleoside diphosphate sugar to generate glucose-1-P and UMP."
1213a1716,1720
> "Q3UUY6-1","RefSeq","NP_835148.2","20333396","Data show the distribution and subcellular localization of prominin-2 within the kidney in situ."
> "Q3UUY6-1","RefSeq","NP_835148.2","18536929","Prominin-2 is widely and abundantly expressed along the epithelia of various segments of the adult male genitourinary tract."
> "Q3UUY6-1","RefSeq","NP_835148.2","17874118","Expression Prominin-2, in the three pairs of major salivary glands, i.e., submandibular-, major sublingual-, and parotid glands in adult mice."
> "Q3UUY6-1","RefSeq","NP_835148.2","17109118","These data show that all the characteristics of prominin-1 are shared by prominin-2, which is in agreement with a possible redundancy in their role as potential organizers of plasma membrane protrusions."
> "Q3UUY6-1","RefSeq","NP_835148.2","12514187","Identification as well as molecular and cell biological characterization"
1215a1723,1724
> "Q9JJ43-1","RefSeq","NP_899011.2","30318414","Rbfox1 is a regulator in the development of cortical interneuron-subtype-specific efferent connectivity."
> "Q9JJ43-1","RefSeq","NP_899011.2","30001398","Rbfox1 is expressed in all retinal ganglion cells types and in certain types of amacrine cells in the ganglion cell and inner nuclear layer. In the developing retina, Rbfox1 is present as early as E12. Although no morphological abnormalities were observed in the retinas of adult Rbfox1 KO mice 2 months after downregulation, these animals have an evident deficiency in depth perception. Publication Status: Online-Only"
1220a1730,1731
> "O89033-1","RefSeq","NP_035929.1","28655335","Dele and Cdc6 G-quadruplex formation is significant in the transcriptional regulation. Dele and Cdc6 G-quadruplex DNA alone possess enhancer and promotor function. Publication Status: Online-Only"
> "O89033-1","RefSeq","NP_035929.1","25264619","CDK1 activation proceeds with concomitant inhibition by CDC6, which tunes the timing of the M-phase entry during the embryonic cell cycle"
1226a1738,1740
> "Q8BLU0-1","RefSeq","NP_958926.1","29487336","The observations propose that FLRT2 can regulate memory functions in the adulthood in a sex-specific manner and might thus contribute to further research on the mechanisms linking sexual dimorphism and cognition. Publication Status: Online-Only"
> "Q8BLU0-1","RefSeq","NP_958926.1","28576770","Fibronectin leucine-rich transmembrane protein 2 (FLRT2), a repulsive ligand of the UNC5 receptor family for neurons, is unexpectedly expressed in endothelial cells specifically in the placental labyrinth."
> "Q8BLU0-1","RefSeq","NP_958926.1","16872596","FLRT2 is expressed in a subset of the sclerotome, adjacent to the region that forms the syndetome in embryo"
1231a1746,1752
> "Q6TCG8-1","RefSeq","NP_940814.1","26834238","PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity"
> "Q6TCG8-1","RefSeq","NP_940814.1","26311497","PAQR3 regulates cholesterol homeostasis by anchoring Scap/SREBP to the Golgi and disruption of such function reduces cholesterol biosynthesis. Publication Status: Online-Only"
> "Q6TCG8-1","RefSeq","NP_940814.1","24035996","This study reveals that PAQR3 has an important physiological function in modulating obesity, energy metabolism, and leptin signaling."
> "Q6TCG8-1","RefSeq","NP_940814.1","23086038","PAQR3 negatively regulates insulin signaling by shunting cytosolic p110alpha to the Golgi apparatus while competing with p85 subunit in forming a PI3K complex with p110alpha."
> "Q6TCG8-1","RefSeq","NP_940814.1","22828136","Loss of PAQR3 is associated with tumorigenesis of colorectal cancers."
> "Q6TCG8-1","RefSeq","NP_940814.1","18550569","RKTG has a suppressive activity in chemical carcinogen-induced mitogenesis and tumor formation in mouse skin."
> "Q6TCG8-1","RefSeq","NP_940814.1","17724343","Reveal a paradigm of spatial regulation of Raf kinase by RKTG via sequestrating Raf-1 to the Golgi apparatus and thereby inhibiting the ERK signaling pathway."
1235a1757
> "Q8BZ60-1","RefSeq","NP_780576.1","23345427","Loss of Stn2 leads to selective missorting of synaptotagmin 1 to the neuronal surface, an elevated synaptic vesicle (SV) pool size, and accelerated SV protein endocytosis."
1245a1768,1774
> "Q8K1E3-1","RefSeq","NP_001272957.1","30888503","The expression pattern of DLK2 indicates that both proteins could play a synergistic role during cell differentiation. Erratum:[Histochem Cell Biol. 2019 May 16;:. PMID: 31093774]"
> "Q8K1E3-1","RefSeq","NP_001272957.1","29057471","The expression of the Dlk2 protein in the limb bud could be detected at embryonic day 11.5."
> "Q8K1E3-1","RefSeq","NP_001272957.1","28863347","Deletion of Dlk2 increased anxiety and depressive-like behaviors and altered the vulnerability to restraint stress."
> "Q8K1E3-1","RefSeq","NP_001272957.1","22306741","KLF4 mediates the transcriptional regulation of Dlk2 in response to IBMX during the early stages of adipogenesis"
> "Q8K1E3-1","RefSeq","NP_001272957.1","22185379","Our results provide the first characterization of Dlk2 transcripts, map the location of the Dlk2 core promoter, and show the role of Sp1 as a key regulator of Dlk2 transcription Publication Status: Online-Only"
> "Q8K1E3-1","RefSeq","NP_001272957.1","21419176","Data show that DLK1 and DLK2 act as inhibitory non-canonical protein ligands for the NOTCH1 receptor that modulate NOTCH signaling."
> "Q8K1E3-1","RefSeq","NP_001272957.1","17320102","Adipogenesis may be modulated by the coordinated expression of Dlk1 and EGFL9/Dlk2."
1248a1778,1780
> "Q925J9-1","RefSeq","NP_598788.2","29293266","B-cell conditional deficient mice for the Med1 subunit display robust somatic hypermutation."
> "Q925J9-1","RefSeq","NP_598788.2","29187405","High MED1 expression is associated with metastasis in breast Cancer."
> "Q925J9-1","RefSeq","NP_598788.2","28673966","Data, including data from studies using cells from transgenic/knockout mice, suggest that Med1 plays role in enamel formation; Med1 induces Alpl via stimulation of Notch1 signaling by forming Notch1-RBP-Jk complex on Alpl promoter. (Med1 = mediator complex subunit 1; Alpl = alkaline phosphatase, liver-bone-kidney; Notch1 = Notch gene homolog 1; RBP-Jk = kappa J region recombining binding protein suppressor of hairless)"
1252a1785
> "P23772-1","RefSeq","NP_032117.1","30295986","BMP and FGF signaling can up-regulate expression of Gata3 in differentiating lens fiber cells through the identified Gata3 enhancer and promoter elements."
1256a1790
> "Q8BHG9-1","RefSeq","NP_848762.1","14667814","Cggbp1 mRNAs of 1.2 and 4.5 kb are transcribed at varying ratios in embryonic, fetal tissues."
1264a1799,1807
> "Q3V0U9-1","RefSeq","NP_001001334.2","30911868","In this work, we performed a quantitative analysis of the expression of Spag6 and Spag16 genes in parallel with the immune-localization of the proteins in several tissues of adult mice."
> "Q3V0U9-1","RefSeq","NP_001001334.2","27566703","Our data indicate that Spag6 plays an essential role in the process of neuronal proliferation and differentiation."
> "Q3V0U9-1","RefSeq","NP_001001334.2","27169488","This novel report demonstrates the requirement of SPAG6 for optimal synapse formation and function. Publication Status: Online-Only"
> "Q3V0U9-1","RefSeq","NP_001001334.2","26130477","Spag6 was continuously expressed in the developing cerebral cortex.  Overexpression of Spag6 caused a significant decrease in neurite number and length of cortical neurons."
> "Q3V0U9-1","RefSeq","NP_001001334.2","26585507","Data show reduced motility of sperm associated antigen 6 (Spag6)-deficient mouse embryonic fibroblasts (MEFs). Publication Status: Online-Only"
> "Q8BXT1-1","RefSeq","NP_080656.2","29758252","These findings suggest that RGS8 participates in modulation of depression-like behavior"
> "Q8BXT1-1","RefSeq","NP_080656.2","26755720","The crystal structure of RGS8 was determined in complex with Galphaq."
> "Q8BXT1-1","RefSeq","NP_080656.2","25902068","ATXN2 interacted selectively with RGS8 mRNA. This interaction was impaired when ATXN2 harbored an expanded polyglutamine. Mutant ATXN2 also reduced RGS8 expression in an in vitro coupled translation Publication Status: Online-Only"
> "Q8BXT1-1","RefSeq","NP_080656.2","18762722","RGS8 null mutant mice were viable, fertile and showed apparently normal development Publication Status: Online-Only"
1266a1810,1811
> "P41971-1","RefSeq","NP_038536.2","29269298","Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis possibly by reducing NLRP3 activation and up-regulating NET expression."
> "P41971-1","RefSeq","NP_038536.2","27538444","Elk-3 contributes to the progression of liver fibrosis by modulating the epithelial-mesenchymal transition via the regulation of Egr-1 under MAPK signaling."
1272,1275c1817,1826
< "Q9QZX7-1","RefSeq","NP_001156783.1","30391323","The studies findings demonstrate neuronal serine racemase association with DISC1 and its agglomerates, which can be modulated by d-Serine."
< "Q9QZX7-1","RefSeq","NP_001156783.1","29913163","Serine racemase (SR) deficiency significantly prevented retinal ganglion cell (RGC) loss in diabetic mice. We conclude that D-serine is a critical factor in the degeneration of RGC in diabetic retinopathy (DR). Targeting SR expression or activity may be a strategy for ameliorating RGC loss in DR."
< "Q9QZX7-1","RefSeq","NP_001156783.1","28892569","This study demonstrated that SR deficiency reduces retinal pigment epithelial cells response to laser-induced inflammatory stimuli, resulting in decreased production of a cascade of pro-angiogenic cytokines, including(.) NO and VEGF, and reduced macrophage recruitment, which contribute synergistically to attenuated angiogenesis."
< "Q9QZX7-1","RefSeq","NP_001156783.1","12021263","Direct calcium binding results in activation in brain"
---
> "Q8WTY4-1","RefSeq","NP_598902.1","24973211","Among 46 putative substrates identified in MN9D neuronal cells, we further evaluated whether caspase-3-mediated cleavage of anamorsin, a recently recognized cell death-defying factor in hematopoiesis, is a general feature of apoptosis."
> "Q8WTY4-1","RefSeq","NP_598902.1","24440520","AM was essential for both autonomous and extrinsic regulation of fetal liver hematopoiesis. This study provided new insight into the molecular regulation of hematopoiesis."
> "Q8WTY4-1","RefSeq","NP_598902.1","21513700","Play cooperatively essential roles in embryogenesis as iron-sulfur cluster proteins."
> "Q8WTY4-1","RefSeq","NP_598902.1","21219862","These data suggest that PKCtheta;, PKCdelta, and p38MAPK activation lead to cell cycle retardation in AM KO MEF cells, and that AM may negatively regulate novel PKCs and p38MAPK in MEF cells."
> "Q8WTY4-1","RefSeq","NP_598902.1","16957168","CIAPIN1 was localized in both the cytoplasm and the nucleus and was accumulated in the nucleolus. Bioinformatic prediction disclosed a putative nuclear localization signal and a putative nuclear export signal within mouse CIAPIN1."
> "Q8WTY4-1","RefSeq","NP_598902.1","14970183","Anamorsin is considered to be a necessary molecule for hematopoiesis that mediates antiapoptotic effects of various cytokines."
> "Q920A1-1","RefSeq","NP_598481.2","30664709","This study shows that cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism"
> "Q920A1-1","RefSeq","NP_598481.2","29628047","CysLT2 receptors were constitutively expressed in the lung, and expression was strengthened in asthmatic mice. Activation of CysLT2 receptors was functionally involved in allergic leukocyte infiltration into the lung."
> "Q920A1-1","RefSeq","NP_598481.2","29282304","CysLT2R signaling, IL-33-dependent group 2 innate lymphoid cell expansion, and IL-33-driven mast cell activation are necessary for induction of type 2 immunopathology and aspirin sensitivity. CysLT2R-targeted drugs may interrupt these processes."
> "Q920A1-1","RefSeq","NP_598481.2","16756959","Findings show that CysLT1 receptor attenuates while CysLT2 receptor facilitates oxygen glucose deprivation -induced PC12 cell death"
1291a1843
> "Q8BZR0-1","RefSeq","NP_783600.1","22216272","GPR82-deficient mice showed decreased serum triacylglyceride levels, increased insulin sensitivity and glucose tolerance, most pronounced under Western diet"
1297a1850,1852
> "Q8VDU5-1","RefSeq","NP_598502.2","29242271","Endothelial cell SNRK/SP1-ITGB1 signaling axis promotes angiogenesis in vivo. Erratum:[Arterioscler Thromb Vasc Biol. 2019 Sep;39(9):e209. PMID: 31433694]"
> "Q8VDU5-1","RefSeq","NP_598502.2","28117339","Using SNRK transgenic and KO mouse models, study found that SNRK decreases cardiac metabolic substrate usage and mitochondrial coupling, while protecting against ischaemia/reperfusion injury. Effects on substrate usage and cell death are dependent on UCP3, which is downregulated through suppression of PPARalpha by Trib3, a novel binding partner of SNRK. Erratum:[Nat Commun. 2017 Aug 30;8:16155. PMID: 28853433] Publication Status: Online-Only"
> "Q8VDU5-1","RefSeq","NP_598502.2","27780848","SNRK in cardiomyocytes is responsible for maintaining cardiac metabolic homeostasis, which is mediated in part by ROCK, and alteration of this homeostasis influences cardiac function in the adult heart."
1309,1312c1864,1867
< "P97792-1","RefSeq","NP_001020363.1","31083261","In this study, a CEACAM-1 overexpression vector was constructed, and the effects of CC1 overexpression post CVB3 infection were analyzed. The results suggested that CC1 may promote CAR expression in cardiomyocytes after CVB3 infection, and CAR may be a potential target for CC1 to regulate the CVB3-induced process of myocardial injury. CC1 might regulate CAR expression by activating the CC1-SYK- TNF-[alpha] signaling axis."
< "P97792-1","RefSeq","NP_001020363.1","28381574","Coxsackievirus and Adenovirus Receptor and potentially an unidentified factor present in mouse serum might be important mediators of Human adenoviral serotype 5 transduction. Publication Status: Online-Only"
< "P97792-1","RefSeq","NP_001020363.1","21674029","CAR exerts important functions in the physiology of several organs in vivo"
< "P97792-1","RefSeq","NP_001020363.1","12823902","The mCAR gene is situated on the distal portion of murine chromosome 16, and is composed of at least eight exons, with intron-exon boundaries similar to those reported for the human CAR gene"
---
> "Q9JJI8-1","RefSeq","NP_075861.1","21529712","Study identified mutations of the Ribosomal Protein L38 (Rpl38) gene in mice exhibiting surprising tissue-specific patterning defects, including pronounced homeotic transformations of the axial skeleton."
> "Q9JJI8-1","RefSeq","NP_075861.1","21062742","Ectopic mineralization in the middle ear and chronic otitis media with effusion caused by RPL38 deficiency in the Tail-short (Ts) mouse."
> "Q9D3D9-1","RefSeq","NP_079589.2","29499186","Both gamma and delta subunits silenced cells displayed decreased ATP synthase function - lowered rate of ADP-stimulated respiration, a two-fold increased sensitivity of respiration to inhibitor oligomycin, and impaired utilization of mitochondrial membrane potential for ADP phosphorylation."
> "Q9D3D9-1","RefSeq","NP_079589.2","24615392","The interaction between Mpl and Atp5d was confirmed by the yeast two-hybrid system, mammalian two-hybrid assay, pull-down experiment, and co-immunoprecipitation study in vivo and in vitro."
1313a1869,1871
> "Q8C1A3-1","RefSeq","NP_766068.1","24800750","MTTR-deficient mouse strain exhibits short-term memory impairment and disturbances in brain choline metabolism."
> "Q8C1A3-1","RefSeq","NP_766068.1","24074862","The Mtrr genotype of either maternal grandparent dictates the developmental potential of their wild-type grandprogeny. These effects are associated with altered DNA methylation patterns and two distinct phenotypes: intrauterine growth defects and congenital malformations that are separable through embryo transfer experiments."
> "Q8C1A3-1","RefSeq","NP_766068.1","18413293","Mtrr deficiency adversely impacts reproductive outcomes and cardiac development in mice."
1318a1877,1878
> "Q3TTY0-1","RefSeq","NP_084348.1","23943622","Sperm surface phospholipase B is activated in response to sterol removal"
> "Q99J78-1","RefSeq","NP_473387.1","10460589","Def8 was first identified in a retroviral gene-trap screen"
1321a1882,1884
> "Q9JLK4-1","RefSeq","NP_038906.2","29661613","CaBP1 and CaBP2 are required for the normal function of the peripheral auditory system."
> "Q9JLK4-1","RefSeq","NP_038906.2","28183797","CaBP2 inhibits CaV1.3 Ca(2+)-channel inactivation."
> "Q9JLK4-1","RefSeq","NP_038906.2","27822497","Results show that CaBP1/caldendrin and CaBP2 are not required for normal gross retinal and synapse morphology but are necessary for the proper transmission of light responses through the retina; CaBP1/caldendrin and CaBP2 likely act by modulating presynaptic Ca(2+)-dependent signaling mechanisms. Publication Status: Online-Only"
1327a1891
> "E9Q6Y4-1","RefSeq","NP_001186250.1","12860387","Cloning and characterization of its expression during spermatogenesis"
1328a1893,1899
> "Q8BPM0-1","RefSeq","NP_766052.2","28682694","The data suggested that Daam1 affected actin assembly during oocyte meiotic division via the regulation of fascin expression."
> "Q8BPM0-1","RefSeq","NP_766052.2","27807130","DAAM1 loss evokes invasive abilities of epithelial cells."
> "Q8BPM0-1","RefSeq","NP_766052.2","27760153","DAAM1 organizes actin filaments into a nodal complex Publication Status: Online-Only"
> "Q8BPM0-1","RefSeq","NP_766052.2","15533824","Daams are expressed in tissues known to require Wnts, so effectors of Wnt signaling during vertebrate development."
> "Q8BPM0-1","RefSeq","NP_766052.2","15464228","Involved in pivotal steps in neuronal cell differentiation and movement"
> "Q91VW9-1","RefSeq","NP_076174.3","28581889","A mouse model lacking Zkscan3 expression, is reported."
> "Q91VW9-1","RefSeq","NP_076174.3","18940803","ZKSCAN3 regulates the expression of several genes favoring tumor progression including integrin beta 4 and VEGF"
1336a1908,1910
> "Q6GQT0-1","RefSeq","NP_001167024.1","29293958","CDC14A activity is necessary for hearing and male fertility."
> "Q6GQT0-1","RefSeq","NP_001167024.1","26283732","Cdc14B knockout (Cdc14B(-/-)) mouse embryonic fibroblasts showed defects in repairing ionizing radiation-induced DNA double-strand breaks, which occurred only at late passages when Cdc14A levels were low."
> "Q6GQT0-1","RefSeq","NP_001167024.1","19270517","CDC14A regulates oocyte maturation and functions to promote the meiosis I-to-meiosis II transition as its homolog does in budding yeast."
1350,1353d1923
< "P59438-1","RefSeq","NP_001005247.2","27333462","Nonsense Mutation in HPS5 gene is associated with hypopigmentation in colitis mice."
< "P59438-1","RefSeq","NP_001005247.2","23672590","Effects of the ru2(d) allele on pheomelanin synthesis were investigated."
< "P59438-1","RefSeq","NP_001005247.2","23030338","These results suggest that the ru2(d) allele suppresses the differentiation of melanocytes through the inhibition of eumelanin synthesis, but stimulates pheomelanin synthesis in melanocytes."
< "P59438-1","RefSeq","NP_001005247.2","22035301","These results suggest that the ru2(d) allele inhibits melanocyte differentiation, and that its impaired differentiation is rescued by excess tyrosine."
1358,1361c1928,1935
< "Q6PHZ8-1","RefSeq","NP_001186171.1","23457522","Genome-wide association study identifies KCNIP4 as an asthma gene in human and in mouse."
< "Q6PHZ8-1","RefSeq","NP_001186171.1","20550899","KChIP4a functions to promote tetrameric assembly and enhance surface expression of Kv4 channels."
< "Q6PHZ8-1","RefSeq","NP_001186171.1","20045463","These data demonstrate that PKA phosphorylation of Kv4.2 plays an important role in the trafficking of Kv4.2 through its specific interaction with KChIP4a."
< "Q6PHZ8-1","RefSeq","NP_001186171.1","15363885","KChIP4 was highly expressed by neurons in layers II-IV of cortex and in hippocampus, thalamus and the Purkinje cell layer of the cerebellum."
---
> "Q8BZ71-1","RefSeq","NP_808375.1","30071129","We provide evidence that endogenous STAC3 incorporates into triads in the absence of the DHPR in myotubes and muscle fibers of dysgenic mice. This finding demonstrates that STAC3 interacts with additional triad proteins and is consistent with its proposed role in directly or indirectly linking the DHPR with the RyR1"
> "Q8BZ71-1","RefSeq","NP_808375.1","29467163","RyR1 Ca2+ release by CaV1.1 depends on Stac3 being bound to critical domain residues in the II-III loop."
> "Q8BZ71-1","RefSeq","NP_808375.1","28112192","Thus, the C1 domain of STAC3 is responsible for its stable incorporation into the voltage-sensor (CaV1.1) of excitation-contraction-coupling complex, whereas the SH3 domain containing the Native American myopathy mutation site may be involved in low-affinity functional interactions in excitation-contraction-coupling. Publication Status: Online-Only"
> "Q8BZ71-1","RefSeq","NP_808375.1","27621462","Stac3 is directly involved in conformational coupling between CaV1.1 and RyR1."
> "Q8BZ71-1","RefSeq","NP_808375.1","27184118","These data together confirm a critical role of STAC3 in excitation-contraction coupling but also suggest that STAC3 may have additional functions in skeletal muscle, at least in the hindlimb muscle. Publication Status: Online-Only"
> "Q8BZ71-1","RefSeq","NP_808375.1","24788338","Stac3 may play a role in preventing precocious myoblast differentiation during skeletal muscle development Erratum:[PLoS One. 2014;9(8):e105240] Publication Status: Online-Only"
> "Q8BZ71-1","RefSeq","NP_808375.1","23818578","STAC3 mediates voltage-induced Ca2+ release and contractility in skeletal muscles."
> "Q8BZ71-1","RefSeq","NP_808375.1","23626854","Stac3 gene plays a critical role in skeletal muscle development and function in mice. Publication Status: Online-Only"
1368,1369d1941
< "Q05BC3-1","RefSeq","NP_001036800.1","29229923","Low Eml1 expression is associated with subcortical band heterotopia. Publication Status: Online-Only"
< "Q05BC3-1","RefSeq","NP_001036800.1","24859200","Eml1 knockdown mimicked the HeCo progenitor phenotype and reexpression rescued it"
1371a1944,1946
> "P41158-1","RefSeq","NP_031949.2","30068599","These data establish that low-level ERK signaling through ELK4 (and ELK1) promotes innate-like alphabeta CD8(+) T cell differentiation, tuning conventional versus innate-like development."
> "P41158-1","RefSeq","NP_031949.2","28275114","Dok-4 can target Elk-4 activity through multiple mechanisms, including binding of the transactivation domain, nuclear exclusion and protein destabilization. Publication Status: Online-Only"
> "P41158-1","RefSeq","NP_031949.2","14770179","SAP-1 is required for Erk-mediated transcriptional events in thymocyte development."
1374,1375d1948
< "Q8BJ52-1","RefSeq","NP_001292380.1","25074937","Data indicate that plasticity-related genes 5 (PRG5) expression is involved in proper spine formation."
< "Q8BJ52-1","RefSeq","NP_001292380.1","20032306","Data show that PRG5 induces filopodia growth independently of Cdc42, and that axon collapse and RhoA activation induced by LPA and myelin-associated neurite inhibitor Nogo-A is attenuated in the presence of PRG5."
1378a1952,1958
> "P52955-1","RefSeq","NP_034821.2","30487221","Loss of LBX1 gene is associated with Hypoventilation."
> "Q9WTR1-1","RefSeq","NP_035836.2","30914062","TRPV2 expression is profoundly downregulated in alveolar macrophages at early time points of cigarette smoke exposure. Reduced TRPV2-mediated phagocytic function renders the lung susceptible to cigarette smoke-induced alveolar space enlargement. Publication Status: Online-Only"
> "Q9WTR1-1","RefSeq","NP_035836.2","29695862","The mast cell is the central structure of acupoints and is activated by acupuncture through TRPV2 channels. Publication Status: Online-Only"
> "Q9WTR1-1","RefSeq","NP_035836.2","28533434","These findings suggest that TRPV2 activation via actin reorganization induced by Gq and G12/13 signaling is involved in LPI-stimulated GLP-1 secretion in enteroendocrine L cells."
> "Q9WTR1-1","RefSeq","NP_035836.2","28481959","Data suggest that knockout of the TRPV2 channel may attenuate macrophage-dependent pro-inflammatory processes and result in better cardiac recovery. TRPV2 may thus represent a novel therapeutic target for treatment of patients undergoing an acute MI Publication Status: Online-Only"
> "Q9WTR1-1","RefSeq","NP_035836.2","14622291","Analysis of glycosylation and localization in comparison to the endogenously expressed protein in F-11 cells"
> "Q9D244-1","RefSeq","NP_084374.2","15693621","The ancestral rodent RNase 6 was subject to accelerated evolution"
1380a1961,1962
> "Q9ES28-1","RefSeq","NP_059098.2","29858246","These findings indicate that AMPK promotes the assembly of beta1Pix, 14-3-3 proteins, and Nedd4-2 into a complex that inhibits ENaC by enhancing Nedd4-2 binding to ENaC and its degradation."
> "Q9ES28-1","RefSeq","NP_059098.2","29891904","The authors show that Arhgef7 interacts with the GTPase TC10 that is closely related to Cdc42. Expression of active TC10 can restore the ability to extend axons in Arhgef7-deficient neurons Publication Status: Online-Only"
1387,1388c1969
< "P97477-1","RefSeq","NP_001278114.1","30415701","In the absence of AURKC, AURKA localizes to chromosomes in a CPC-dependent manner. These data suggest that AURKC prevents AURKA from localizing to chromosomes by competing for CPC binding. This competition is important for adequate spindle length to support meiosis I. There is also a unique requirement for AURKB to negatively regulate AURKC to prevent aneuploidy."
< "P97477-1","RefSeq","NP_001278114.1","29842884","AURKA is expressed in several cell types in the testis. Spermatogonia and spermatocytes express AURKA as expected based on the known role of this kinase in cell division. Surprisingly, we also found AURKA localized to spermatids and the flagellum of spermatozoa."
---
> "Q9JLC6-1","RefSeq","NP_705617.2","30515906","Upregulation of TEF expression significantly retarded Bladder Cancer cell growth by inhibiting the G1/S transition via regulating AKT/FOXOs signalling."
1389a1971,1973
> "Q9R1X4-1","RefSeq","NP_035719.1","25448545","The obtained results suggest that Tim is expressed in neuronal tissues in a spatiotemporally regulated manner and involved in developmental stage-specific neuronal functions."
> "Q9R1X4-1","RefSeq","NP_035719.1","23266470","The Phosphorylation of timeless protein by Hck and Fyn induced Tim ubiquitylation on K48 and subsequent degradation, while c-Src and c-Yes led to K63-linked ubiquitylation and Tim accumulation within cells."
> "Q9R1X4-1","RefSeq","NP_035719.1","23418588","Data indicate that RNAi-mediated knockdown of TIMELESS (TIM) in NIH3T3 and U2OS cells shortens the period by 1 hour and diminishes DNA damage-dependent phase advancing."
1392a1977
> "Q7M760-1","RefSeq","NP_997185.1","26808229","Trabid regulates inflammatory T cell responses via facilitation of histone modifications at the promoters of Il12 and Il23, which involved deubiqutination and stabilization of the histone demethylase Jmjd2d."
1399a1985,1989
> "Q9R164-1","RefSeq","NP_064324.2","26246563","A novel cellular protein, Zfp111, binds to the JSRV Env protein, and this binding plays a role in retroviral transformation."
> "P10518-1","RefSeq","NP_032551.3","27650074","This study demonstrated for the first time the involvement of striatal delta-ALA-D activity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model and its correlation with the MPO activity."
> "P10518-1","RefSeq","NP_032551.3","23056320","Similar to its role at the beta-globin promoter, KLF1 induces factor recruitment and chromatin changes at the Alad1b promoter in a temporally-specific manner"
> "P10518-1","RefSeq","NP_032551.3","21640720","The data supports the hypothesis that ALAD, an important enzyme for heme synthesis, is also important as a proteasome interacting protein."
> "Q9D154-1","RefSeq","NP_079705.2","30459233","These results indicate that liver FoxO1 promotes serpinB1 expression in hepatic insulin resistance and that non-cell-autonomous factors contribute to FoxO1-dependent effects on serpinB1 expression in the liver."
1403a1994,1995
> "Q9QXC1-1","RefSeq","NP_067539.1","23562279","Fetuin-B-deficient female mice are infertile due to an early block to fertilization."
> "Q9QXC1-1","RefSeq","NP_067539.1","15499407","Overexpression of Fetuin-B in skin squamous carcinoma cells led to suppression of tumor growth in nude mice."
1417a2010,2011
> "Q9ESG6-1","RefSeq","NP_573463.1","29189936","P2Y14 receptor activation decreases interleukin-6 production and glioma GL261 cell proliferation in microglial transwell cultures. These data suggest that P2Y14 receptors may be a key a receptor involved in glioma cell-microglial/macrophage communication in the tumor environment."
> "Q9ESG6-1","RefSeq","NP_573463.1","28804125","Present study suggests that P2Y14 expression could be used as a phenotypic marker to further dissect placental HSPCs."
1418a2013,2016
> "Q8BH75-1","RefSeq","NP_080535.2","26390156","Data suggest that ring finger protein 41 Nrdp1 terminates T cell antigen receptors (TCRs) signaling by inactivating Zap70 kinase."
> "Q8BH75-1","RefSeq","NP_080535.2","26085571","The novel Pdx1-Clec16a-Nrdp1 pathway this study describes provides a genetic basis for the pathogenesis of mitochondrial dysfunction in multiple forms of diabetes."
> "Q8BH75-1","RefSeq","NP_080535.2","22707723","Demonstrate that Nrdp1-mediated ubiquitination and activation of C/EBPbeta contributes to a ubiquitin-dependent nonproteolytic pathway that up-regulates Arg1 expression and promotes M2 macrophage polarization"
> "Q8BH75-1","RefSeq","NP_080535.2","21738612","Nrdp1 may be a key mediator in the development of cardiac dysfunction after DOX treatment and associated with inhibition of Akt, ERK1/2 and STAT3."
1424a2023,2024
> "Q9D4H1-1","RefSeq","NP_079864.1","23844030","Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion. Publication Status: Online-Only"
> "Q9D4H1-1","RefSeq","NP_079864.1","12624092","The structure of the Ral-binding domain of Sec5"
1436a2037,2045
> "Q9D411-1","RefSeq","NP_001240817.1","26940607","Phosphorylated Tssk4 might participate in testis genes expressions by phosphorylating Crem at Ser-117."
> "Q9D411-1","RefSeq","NP_001240817.1","26961893","Testis-specific serine/threonine protein kinase 4 (Tssk4) phosphorylates Odf2 at Ser-76 Publication Status: Online-Only"
> "Q9D411-1","RefSeq","NP_001240817.1","25361759","Findings reveal that Tssk4 is required for maintaining the structural integrity of sperm flagellum and male fertility."
> "Q9D411-1","RefSeq","NP_001240817.1","23599433","HSP90 function abolished the catalytic activities of TSSK4 and -6 but did not significantly alter the specific activities of TSSK1 and -2. Inhibition of HSP90 resulted in increased TSSK ubiquitination and proteasomal degradation"
> "Q9D411-1","RefSeq","NP_001240817.1","23054012","Autophosphorylation at Thr-197 plays a critical role in maintaining Tssk4 kinase activity, which might be involved in spermiogenesis."
> "Q71FD7-1","RefSeq","NP_598515.3","25852081","Suggest migfilin regulates cardiac hypertrophy in transverse aortic constriction."
> "Q71FD7-1","RefSeq","NP_598515.3","24165133","C-terminal LIM domains of migfilin dictate its focal adhesion localization, and these domains mediate an interaction with kindlin in vitro and in cells, demonstrating that kindlin is important for normal migfilin dynamics."
> "Q71FD7-1","RefSeq","NP_598515.3","22649246","This study demonistrated that a molecular mechanism whereby FlnA loss impaired G2 to M phase entry, leading to cell cycle prolongation, compromised neural progenitor proliferation, and reduced brain size."
> "Q71FD7-1","RefSeq","NP_598515.3","14757752","Results suggest that a novel LIM protein Cal induces cardiomyocyte differentiation through its dynamic intracellular shuttling and association with CSX/NKX2-5"
1441a2051,2052
> "Q60823-1","RefSeq","NP_031460.1","30258434","Study has revealed a new intracellular mechanism in which Akt2 regulates ICOS expression via FoxO-1 and this signaling axis regulates the differentiation and function of NKT17 cells. This study provides a new linker between cell metabolism and function of iNKT cells. Publication Status: Online-Only"
> "Q60823-1","RefSeq","NP_031460.1","29933193","This study shows that over-expressed miRNA-200b ameliorates ulcerative colitis-related colorectal cancer in mice through orchestrating epithelial-mesenchymal transition and inflammatory responses by channel of AKT2"
1445a2057,2061
> "Q60963-1","RefSeq","NP_038765.2","28608449","Resveratrol downregulates Lp-PLA2 expression by inhibiting oxidative stress via SIRT1 pathway in a mouse model of chronic inflammation."
> "Q60963-1","RefSeq","NP_038765.2","26232205","Lp-PLA2 augments the inflammatory response after MI and antagonizes healing by disrupting the balance between inflammation and repair."
> "Q60963-1","RefSeq","NP_038765.2","16371369","PAF acetylhydrolases play key roles in the hydrolysis of F2-isoprostanes esterified on phospholipids in vivo"
> "Q60963-1","RefSeq","NP_038765.2","12551946","Deletion of both subunits induces a marked loss of germ cells at an early spermatogenic stage."
> "Q60963-1","RefSeq","NP_038765.2","11833932","PAF acetylhydrolase activity in the uterus in early pregnancy was not produced locally but probably resulted from the influx of the plasma form of the enzyme"
1450,1451d2065
< "Q8BK06-1","RefSeq","NP_001074959.1","27197753","FBXO9 directly interacted with PPAR gamma through the activation function-1 domain and ligand-binding domain. FBXO9 decreased the protein stability of PPAR gamma through induction of ubiquitination. Publication Status: Online-Only"
< "Q8BK06-1","RefSeq","NP_001074959.1","20459822","ICK and FBX9 are divergently transcribed from a bidirectional promoter that is GC-rich and contains a CpG island. Publication Status: Online-Only"
1454a2069,2071
> "G5E8K5-1","RefSeq","NP_733926.2","30562487","Results indicate an obligatory role for ankyrin-G protein (AnkG) in lens morphogenesis and growth."
> "G5E8K5-1","RefSeq","NP_733926.2","30046097","ANK3 functions in neuronal microtubule dynamics through GSK3 and its downstream substrate CRMP2. Publication Status: Online-Only"
> "G5E8K5-1","RefSeq","NP_733926.2","29963618","Study shows that simultaneous ablation of neuronal Neurofascin and Ankyrin G in young and adult mice reveals age-dependent increase in nodal stability in myelinated axons and differential effects on the lifespan. Publication Status: Online-Only"
1457a2075,2076
> "Q02357-1","RefSeq","NP_112435.2","28751503","This study highlights the first direct examination of allelic heterogeneity of the Ank-1 gene in the context of malaria resistance in mouse models. Publication Status: Online-Only"
> "Q02357-1","RefSeq","NP_112435.2","27848995","Parasites in ankyrin-1 (Ank-1) mutation erythrocytes grew normally, but red cells showed resistance to merozoite invasion. Publication Status: Online-Only"
1460,1461c2079,2081
< "Q8CHH9-1","RefSeq","NP_001239261.1","27084579","SEPT8 modulates beta-amyloidogenic processing of APP through a mechanism affecting the intracellular sorting and accumulation of BACE1."
< "Q8CHH9-1","RefSeq","NP_001239261.1","21770032","Signaling protein ras-related protein rab-7A and septin 8 levels were significantly higher in hippocampus of poor contextual fear conditioning extinguishers."
---
> "Q9QZ85-1","RefSeq","NP_068564.4","26934976","The study determined the crystal structure of an oligomerization-impaired Irga6 mutant bound to a non-hydrolyzable GTP analog. Publication Status: Online-Only"
> "Q9QZ85-1","RefSeq","NP_068564.4","26247512","These data identify Toxoplasma gondii GRA7 as a regulator for ROP18-specific inactivation of murine Irga6."
> "Q9QZ85-1","RefSeq","NP_068564.4","25118287","ROP5 uses a highly polymorphic surface to bind adjacent to the nucleotide-binding domain of an IRG and that this produces a profound allosteric change in the IRGa6 structure. [Rop5]"
1466,1471c2086,2088
< "P97443-1","RefSeq","NP_001153599.1","30061404","These findings provide functional evidence for a role of Smyd1, or any member of the Smyd family, in regulating cardiac energetics in the adult heart, which is mediated, at least in part, via modulating PGC-1alpha."
< "P97443-1","RefSeq","NP_001153599.1","29499397","The data suggest that skNAC and Smyd1 might be major players in the processes of myofibrillogenesis and sarcomerogenesis, probably specifically at later stages."
< "P97443-1","RefSeq","NP_001153599.1","27663768","Smyd1 is responsible for restricting growth in the adult heart, with its absence leading to cellular hypertrophy, organ remodeling, and fulminate heart failure. Molecular studies reveal Smyd1 to be a muscle-specific regulator of gene expression and indicate that Smyd1 modulates expression of gene isoforms whose expression is associated with cardiac pathology. Activation of Smyd1 can prevent pathological cell growth."
< "P97443-1","RefSeq","NP_001153599.1","26935107","This work illustrates a crucial role for SMYD1 in skeletal muscle physiology and myofibril integrity."
< "P97443-1","RefSeq","NP_001153599.1","12011100","Similar kinetics of induction and localization of m-Bop and skNAC during the induction of myogenesis in cultured C2C12 cells suggests a possible associated role for these proteins during this process."
< "P97443-1","RefSeq","NP_001153599.1","11923873","Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis."
---
> "Q8BGY9-1","RefSeq","NP_071308.2","27013347","Our findings suggest that CHT protein levels preferentially impact the capacity for ACh release afforded by mobilization of reserve pool vesicles"
> "Q7TPG5-1","RefSeq","NP_796207.2","24139797","TAFA4 is required to maintain the normal threshold of injury-induced mechanical and chemical pain hypersensitivity and strongly support a potential role of TAFA4 as a potent analgesic in the settings of inflammation and neuropathy."
> "Q571I4-1","RefSeq","NP_766499.2","15289607","Also known as SgK223, a member of the NKF3 family of protein kinases predicted to be catalytically inactive."
1476,1477d2092
< "Q8VDQ1-1","RefSeq","NP_001239554.1","17449869","15-oxoprostaglandin-Delta13-reductase (PGR-2) catalyzes the reaction converting 15-keto-PGE2 to 13,14-dihydro-15-keto-PGE2"
< "Q8VDQ1-1","RefSeq","NP_001239554.1","15229897","This mouse gene encodes a putative NADPH-dependent oxidoreductase. We report the crystal structure of the putative oxidoreductase determined by the semi-automated high-throughput pipeline of the Joint Center for Structural Genomics"
1484a2100
> "Q8BZS9-1","RefSeq","NP_598702.1","17239371","Electron microscope immunocytochemistry detected the presence of Dhx32 in the mitochondria of hepatocytes"
1488a2105,2109
> "P58682-1","RefSeq","NP_573475.2","30455267","The present study reveals a previously unknown role of TLR8 in the maintenance of neuropathic pain, suggesting that miR-21-TLR8 signaling may be potential new targets for drug development against this type of chronic pain."
> "P58682-1","RefSeq","NP_573475.2","29777026","The activation of TLR8, TLR7, or TLR3 results in dendritic shortening, and TLR7 and TLR3 but not TLR8 also control axonal growth."
> "P58682-1","RefSeq","NP_573475.2","28963929","Evaluation of the adjuvant effect of agonists of toll-like receptor 4 and 7/8 in a vaccine against leishmaniasis"
> "P58682-1","RefSeq","NP_573475.2","27798161","TLR8 coupling with SOCS-1 inhibits TLR7-mediated antiviral immunity during WNV infection in mice."
> "P58682-1","RefSeq","NP_573475.2","16737960","TLR8-mediated MEKK3-dependent IKKgamma phosphorylation might play an important role in the activation of IKK complex, leading to IkappaBalpha phosphorylation"
1496a2118
> "Q8CDG1-1","RefSeq","NP_067283.1","30590800","We show that mitochondria-anchored TDRKH controls multiple steps of pachytene piRNA biogenesis in mice. TDRKH specifically recruits MIWI, but not MILI, to engage the piRNA pathway. It is required for the production of the entire MIWI-bound piRNA population and enables trimming of MILI-bound piRNAs."
1507,1508c2129,2132
< "Q8CG19-1","RefSeq","NP_064303.2","27956181","LTBP1 has a role in female reproduction"
< "Q8CG19-1","RefSeq","NP_064303.2","25805620","Data show the complete knockout of both isoforms of LTBP-1 leads to defective cardiovascular development and subsequent perinatal lethality supporting the idea that LTBP-1 is essential in the development of the great arteries and cardiac cushions."
---
> "Q9WTP6-1","RefSeq","NP_058591.2","24740601","In addition to AK1 and AK2, which we previously demonstrated are present in outer dense fibers and mitochondrial sheath of the mouse sperm tail, we show that another AK, AK8, is present in a third flagellar compartment, the axoneme."
> "Q9WTP6-1","RefSeq","NP_058591.2","24548998","Results suggest that AK2 is an associated activator of DUSP26 and suppresses cell proliferation by FADD dephosphorylation, postulating AK2 as a negative regulator of tumour growth."
> "Q9WTP6-1","RefSeq","NP_058591.2","20876536","Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response."
> "Q9WTP6-1","RefSeq","NP_058591.2","20728450","Reduced Akt2 leads to up-regulation of Rab4a expression in cardiomyocytes in a cell-autonomous fashion that may involve activation of PPARalpha."
1513a2138,2139
> "Q3TQR0-1","RefSeq","NP_663558.1","15983387","The Frag1 signal pathway, by linking replication stress surveillance with apoptosis induction, plays a central role in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis."
> "Q8K249-1","RefSeq","NP_742047.1","29358324","Data (including data from studies conducted with cells from knockout mice) suggest that Cd300e on the surface of monocytes or mast cells recognizes the ligand sphingomyelin and thereby regulates non-classical and intermediate immunologic functions through FcRgamma and DAP12. (Cd300e = CD300 antigen like family member E; FcRgamma = Fc receptor subunit gamma; DAP12 = DNAX-activation protein-12)"
1517c2143,2148
< "Q8R3L2-1","RefSeq","NP_001032967.1","12107429","The complex expression pattern and unique protein sequence, including an acidic amino terminal and putative transcription activation domain, suggests that Nulp1 may have a distinct role in embryonic development of many organs, including the adult brain."
---
> "Q62225-1","RefSeq","NP_034025.1","29593227","We conclude that the Cish-SH2 domain is essential for PLC-gamma1 regulation in TCR-stimulated CD8(+) T cells. Publication Status: Online-Only"
> "Q62225-1","RefSeq","NP_034025.1","29050767","CISH mediates control of M. tuberculosis in mice early after infection via regulation of innate immune mechanisms."
> "Q62225-1","RefSeq","NP_034025.1","28038963","CIS interacted with phosphorylated EpoR at Y401, which was critical for the activation of STAT5 and ERK."
> "Q9Z222-1","RefSeq","NP_058584.3","24105809","These data clearly suggest that GCNT2 functions in vivo together with beta3GnT2 to determine poly-N-acetyllactosamine (PLN) levels in olfactory neurons by regulating beta1,6-branches that promote PLN extension."
> "Q9Z222-1","RefSeq","NP_058584.3","23006775","These results identify a novel function for beta3GnT2 glycosylation in maintaining expression of layer-specific vomeronasal receptors"
> "Q9Z222-1","RefSeq","NP_058584.3","22559903","Beta3GnT2(-/-) mice exhibit a relatively small deficit in their ability to discriminate divergent odors. Publication Status: Online-Only"
1522a2154,2156
> "P19258-1","RefSeq","NP_032648.1","29106596","Data show that elevated rGMP incorporation is associated with early-onset mtDNA depletion in liver and late-onset multiple deletions in brain of Mpv17-/- mice, suggesting aberrant ribonucleotide incorporation is a primary mtDNA abnormality that can result in pathology."
> "P19258-1","RefSeq","NP_032648.1","26760297","Changes in the expression of factors involved in mitochondrial deoxynucleotide homeostasis indicate a remodeling of nucleotide metabolism in MPV17 disease models Publication Status: Online-Only"
> "P19258-1","RefSeq","NP_032648.1","25205723","The nuclear gene MPV17, whose mutated forms are associated with hepatocerebral MDDS in humans, plays a so-far unknown role in mtDNA maintenance Review article"
1524a2159
> "Q7TMK6-1","RefSeq","NP_573518.2","19793914","Results identify Hook2, a linker protein that is essential for regulation of the microtubule network at the centrosome, as a binding partner of CENP-F."
1531a2167,2168
> "Q8VEL0-1","RefSeq","NP_081685.1","21792907","Mospd1 plays a pivotal role in the developmental regulation at the switch between mesenchymal and epithelial cells."
> "Q9DBU5-1","RefSeq","NP_083050.1","16204183","Rnf6 controls cellular LIMK1 concentrations and indicate a new function for the ubiquitin/proteasome system in regulating local growth cone actin dynamics Erratum:[Genes Dev. 2005 Nov 1;19(21):2643]"
1536a2174,2176
> "O08532-1","RefSeq","NP_033914.1","30355732","The interaction between alpha2delta-1 and NMDARs is of high physiological relevance"
> "O08532-1","RefSeq","NP_033914.1","16460711","Alpha(2)-delta Type 1 subunit of voltage-gated calcium channels is the major binding protein for pregabalin in the brain and spinal cord."
> "O08532-1","RefSeq","NP_033914.1","1847144","This study of the rabbit ortholog of dihydropyridine-sensitive calcium channel alpha 2 provides N-terminal sequencing evidence of the cleavage junction of the alpha2 and delta subunits from the preprotein"
1547c2187,2191
< "Q8BHZ5-1","RefSeq","NP_001129083.1","17043244","Characterizes the hamster ortholog and suggests that it may modulate the ability of the proteasome to degrade retroviral cores upon cellular infection."
---
> "Q61423-1","RefSeq","NP_067250.2","26152125","Data show that suprachiasmatic nucleus (SCN) explants from potassium channel Kv1.4(-/-)period2 protein Per2(Luc) and potassium channel Kv4.2(-/-) period2 protein Per2(Luc) mice have significantly shorter circadian periods in PER2 rhythms."
> "Q9QZ03-1","RefSeq","NP_038929.2","26979775","Under oxidative stress-loaded conditions, astrocytes exhibit increased zinc clearance activity and this is due, at least in part, to increased ZIP1 expression."
> "Q9QZ03-1","RefSeq","NP_038929.2","25089007","Mouse Zrt/Irt-like protein 1 (ZIP1) uptake of zinc is affected by divalent metal cations"
> "Q9QZ03-1","RefSeq","NP_038929.2","15054103","ZIP1 and ZIP3 zinc uptake transporter activity is controlled by zinc-stimulated endocytosis"
> "Q9QZ03-1","RefSeq","NP_038929.2","14525987","ZIP1, ZIP2 and ZIP3 may play cell-specific roles in zinc homeostasis rather than primary roles in the acquisition of dietary zinc"
1561,1564c2205,2209
< "Q80XP9-1","RefSeq","NP_001258607.1","26861815","WNK3 knockout mice show faster neurological functional recovery after occlusion of the left middle cerebral artery."
< "Q80XP9-1","RefSeq","NP_001258607.1","16357011","WNK3 is likely a component of one of the mechanisms that determines the balance between renal NaCl reabsorption and K+ secretion."
< "Q80XP9-1","RefSeq","NP_001258607.1","16275913","Effects of WNK3 on these transporters and their coexpression in renal epithelia implicate WNK3 in NaCl, water, and blood pressure homeostasis, perhaps via signaling downstream of vasopressin"
< "Q80XP9-1","RefSeq","NP_001258607.1","16275911","Suggest that WNK3 is part of the Cl(-)/volume-sensing mechanism necessary for the maintenance of cell volume during osmotic stress and the dynamic modulation of GABA neurotransmission"
---
> "P41242-1","RefSeq","NP_034898.1","29440352","Matk plays a critical role in bone metabolism by impairing the functions of osteoclasts and osteoblasts via distinct mechanisms involving inhibition of c-Src-dependent and -independent signaling pathways."
> "Q7TPG7-1","RefSeq","NP_877959.2","30137205","Chemokine-like protein TAFA-2"
> "Q3UP24-1","RefSeq","NP_001028539.1","30279514","This study shows that NLRC4 suppresses IL-17A-mediated neutrophil-dependent host defense through upregulation of IL-18 and induction of necroptosis during Gram-positive pneumonia"
> "Q3UP24-1","RefSeq","NP_001028539.1","29778503","This is the first report of a mutation in the LRR domain of NLRC4 causing autoinflammatory disease. c.G1965C/p.W655C NLRC4 increased inflammasome activation in vitro. Data generated from various NLRC4 mutations provides evidence that the LRR-LRR interface has an important and previously unrecognized role in oligomerization of the NLRC4 inflammasome complex."
> "Q3UP24-1","RefSeq","NP_001028539.1","15190255","Cell death triggered by stimuli that engage caspase-1 was ablated in macrophages lacking either ASC or Ipaf, suggesting a coupling between the inflammatory and cell death pathways [IPAF]"
1573,1577c2218,2221
< "Q91WE9-1","RefSeq","NP_001239239.1","29453251","Novel adipokine, FAM19A5, was capable of inhibiting postinjury neointima formation via sphingosine-1-phosphate receptor 2-G12/13-RhoA signaling."
< "Q91WE9-1","RefSeq","NP_001239239.1","29138422","Our results suggest that FAM19A5 and its target receptor FPR2 can act as novel endogenous ligand/receptor to negatively regulate osteoclastogenesis. They might be regarded as potential targets to control osteoclast formation and bone disorders. Publication Status: Online-Only"
< "Q52KR2-1","RefSeq","NP_001020238.1","26651291","Lrig2 has a role in negative regulation of ectodomain shedding of axon guidance receptors by ADAM17 protease"
< "Q52KR2-1","RefSeq","NP_001020238.1","24023893","Phenotype of Lrig2E12-/- mice showed that Lrig2 was a promoter of PDGFB-induced glioma Publication Status: Online-Only"
< "Q52KR2-1","RefSeq","NP_001020238.1","24086156","At later stages, Lrig1 expression is sustained in non-sensory tissues, whereas Lrig2 levels are enhanced in neurons and sensory epithelia"
---
> "Q5SWK7-1","RefSeq","NP_083138.2","30543180","N the absence of both RNF145 and gp78, Hrd1, a third UBE2G2-dependent E3 ligase, partially regulates HMGCR activity. Our findings reveal a critical role for the sterol-responsive RNF145 in HMGCR regulation and elucidate the complexity of sterol-accelerated HMGCR degradation Publication Status: Online-Only"
> "Q5SWK7-1","RefSeq","NP_083138.2","29068315","Mechanistic studies show that RNF145 triggers ubiquitination of SCAP on lysine residues within a cytoplasmic loop essential for COPII binding, potentially inhibiting its transport to Golgi and subsequent processing of SREBP-2. Publication Status: Online-Only"
> "Q5SWK7-1","RefSeq","NP_083138.2","28231341","We report the identification of RNF145 as an ER-resident E3 ubiquitin ligase that is transcriptionally controlled by LXR. Publication Status: Online-Only"
> "Q5SWK7-1","RefSeq","NP_083138.2","26194095","Implicated in proteostasis of Nox2 complex Publication Status: Online-Only"
1579,1581c2223,2228
< "Q91X88-1","RefSeq","NP_080927.1","25085363","Findings suggest that PomGnT1 promotes GBM progression via activation of beta-catenin and may serve as a prognostic factor for glioma patient survival as well as a novel molecular target for anticancer therapy in malignant glioma."
< "Q91X88-1","RefSeq","NP_080927.1","17034757","From these findings, we propose that fukutin forms a complex with POMGnT1 and may modulate its enzymatic activity."
< "Q91X88-1","RefSeq","NP_080927.1","16458488","The present study provides the first genetic animal model to further dissect the roles of POMGnT1 in MEB disease."
---
> "Q8BHK2-1","RefSeq","NP_839941.1","24581800","Beta1-beta3 is more likely to form a di-polymer than beta1-beta1 based on molecular interaction analysis, including potential energy analysis"
> "Q8BHK2-1","RefSeq","NP_839941.1","15334053","SCN3B mediates a p53-dependent apoptotic pathway and may be a candidate for gene therapy combined with anticancer drugs."
> "Q6P1B1-1","RefSeq","NP_573479.3","23131567","These results suggest an essential role for APP1-mediated peptide metabolism in body and brain development, and indicate a strong causal link between APP1 deficiency and peptiduria."
> "Q80YE4-1","RefSeq","NP_031403.2","29556912","The results showed that AATYK knockdown inhibited Oligodendrocytes differentiation and the expression of myelin genes in vitro."
> "Q80YE4-1","RefSeq","NP_031403.2","24672056","LMTK1 negatively controls dendritic formation by regulating Rab11A-positive endosomal trafficking."
> "Q80YE4-1","RefSeq","NP_031403.2","22573681","Overexpression of the unphosphorylated mutant LMTK1-S34A dramatically promotes axonal outgrowth in cultured neurons."
1587a2235,2236
> "Q5XJY6-1","RefSeq","NP_778192.3","26658157","Data suggest that Fanconi anemia complementation group B protein Fancb(-/y) mouse model for studying the Fanconi anemia (FA) pathway not only in germ cell development but also in the maintenance of hematopoietic stem cell (HSC) function. Publication Status: Online-Only"
> "Q5XJY6-1","RefSeq","NP_778192.3","26123487","FANCB functions at critical stages of germ cell development and reveal a novel function of the FA pathway in the regulation of H3K9 methylation in the germline."
1601a2251,2258
> "Q8R0X7-1","RefSeq","NP_033189.2","29301259","Partial genetic deletion of Sgpl1 protected mice against ventilator induced lung injury. Publication Status: Online-Only"
> "Q8R0X7-1","RefSeq","NP_033189.2","28931805","Study verifies the role of a high-ranked gene in dysregulation of sphingolipid metabolism in the disease and demonstrate that inhibiting the enzyme, sphingosine-1-phosphate lyase 1 (SPL), has neuroprotective effects in Huntington's disease models. Publication Status: Online-Only"
> "Q8R0X7-1","RefSeq","NP_033189.2","28706199","High SGPL1 expression is associated with Huntington's disease. Erratum:[Sci Rep. 2018 May 24;8(1):8266. PMID: 29795393] Publication Status: Online-Only"
> "Q8R0X7-1","RefSeq","NP_033189.2","12584204","SPL may be involved in the regulation of intracellular S1P levels during this differentiation"
> "Q30D77-1","RefSeq","NP_082046.2","23139630","Col24alpha1 imparts some of its regulatory control on osteoblast differentiation and mineralization at least partially through interaction with integrin beta3 and the transforming growth factor beta (TGF-beta) /Smads signaling pathway."
> "Q30D77-1","RefSeq","NP_082046.2","18382892","These findings lend further support to the hypothesis that collagen XXIV may be implicated in the formation of a mineralization-competent bone matrix."
> "Q30D77-1","RefSeq","NP_082046.2","16373341","Data report the characterization of the proximal promoter of the mouse collagen XXIV gene (Col24a1) and its regulation by CREB-AP1 in osteoblastic cells."
> "Q30D77-1","RefSeq","NP_082046.2","12874293","Collagen XXIV is an ancient molecule that may contribute to the regulation of type I collagen fibrillogenesis at specific anatomical locations during fetal development"
1609a2267,2282
> "P39428-1","RefSeq","NP_033447.2","29506272","The authors demonstrated that miR-23b mediated immunosuppression during late sepsis by inhibiting the noncanonical NF-kappaB signal and promoting the proapoptotic signal pathway by targeting NIK, TRAF1, and XIAP."
> "P39428-1","RefSeq","NP_033447.2","29358227","TRAF-1-/- mice fed with high fat diet failed to gain weight, and showed improved insulin resistance, increased lipid breakdown in adipocytes and UCP-1-enabled thermogenesis."
> "P39428-1","RefSeq","NP_033447.2","27893701","This study shows that Traf1 gene knock-out mice show increased susceptibility to lipopolysaccharide-induced septic shock"
> "Q9QWZ1-1","RefSeq","NP_035362.2","23468651","HUS1 acts as a component of the canonical 9-1-1 complex during meiotic prophase I to promote DSB repair and further propose that RAD1 and TOPBP1 respond to unsynapsed chromatin through an alternative mechanism that does not require RAD9 or HUS1."
> "Q9QWZ1-1","RefSeq","NP_035362.2","21637962","The rad1 protein is required for repairing DNA lesions induced by UV-light, HU and gamma rays, and for mediating G(2)/M and S/M checkpoint controls."
> "Q9QUS9-1","RefSeq","NP_001155213.1","17998566","Immunoreactivity to INGAP localized to the pancreatic endocrine cells in mouse. INGAP and/or related group 3 Reg proteins have a conserved expression in the pancreatic islet."
> "Q9JM63-1","RefSeq","NP_001034573.1","31042800","Our studies highlight that IRS-1, by regulating BMAL1, is an important regulator of Kir4.1 in Muller cells and the dysfunctional signaling mediated by IRS-1 may be detrimental to Kir4.1."
> "Q9JM63-1","RefSeq","NP_001034573.1","30110571","Modest reduction in Kir4.1 expression results in impaired K conservation, which appears to be mediated by reduced expression of activated NCC."
> "Q9JM63-1","RefSeq","NP_001034573.1","29897283","Association of Nedd4-2 with Kir5.1 facilitates the ubiquitination of Kir4.1, thereby regulating its plasma expression in the distal convoluted tubule"
> "Q9JM63-1","RefSeq","NP_001034573.1","30204081","This was accompanied by neuronal loss and neuro-axonal dysfunction in adult OL-Kcnj10 cKO mice as shown by delayed visual evoked potentials, inner retinal thinning and progressive motor deficits. Axon pathologies in OL-Kcnj10 cKO were exacerbated after WM injury in the spinal cord. Publication Status: Online-Only"
> "O35566-1","RefSeq","NP_033972.2","29274410","CD151 is a critical novel host factor of nuclear export signaling."
> "O35566-1","RefSeq","NP_033972.2","26245294","In complex with P2Y12 receptor contributes to thrombus growth and stability"
> "O35566-1","RefSeq","NP_033972.2","26136426","Tetraspanin CD151 Is a Negative Regulator of FcepsilonRI-Mediated Mast Cell Activation"
> "O35566-1","RefSeq","NP_033972.2","25486358","Integrin-associated CD151 represses mammary branching morphogenesis by controlling progenitor cell activities, extracellular matrix integrity and transcription program."
> "O35566-1","RefSeq","NP_033972.2","12805567","CD151 plays a key role in selectively strengthening alpha6beta1 integrin-mediated adhesion to laminin-1"
> "O35566-1","RefSeq","NP_033972.2","12456024","CD151 may be involved in the interaction of platelets with the subendothelial matrix at sites of vascular damage [review] Review article"
1611a2285,2287
> "Q9CS84-1","RefSeq","NP_796258.2","30262834","The Nrxn1beta-LRRTM2 interface involves Ca(2+)-mediated interactions and overlaps with the Nrxn-neuroligin interface. Publication Status: Online-Only"
> "Q9CS84-1","RefSeq","NP_796258.2","22196734","Findings uncover SAM68 as a key regulator of dynamic control of Nrxn1 molecular diversity and activity-dependent alternative splicing in the central nervous system."
> "Q6PIP5-1","RefSeq","NP_080425.3","24633332","Results indicate that OVA66 is important in oncogenic transformation, promoting proliferation, cell migration and reducing apoptosis via hyperactivating PI3K/AKT and ERK1/2 MAPK signaling pathway. Publication Status: Online-Only"
1617,1626c2293,2294
< "P0C605-1","RefSeq","NP_001013855.1","30327468","Prkg1 cascade role in platelet activation and thrombosis. Erratum:[Nat Commun. 2018 Nov 20;9(1):4969. PMID: 30459325] Publication Status: Online-Only"
< "P0C605-1","RefSeq","NP_001013855.1","30152261","These data thus demonstrate the existence of two differently distributed cGKI isoforms in the dorsal root ganglion, and may provide insight into the cellular and molecular mechanisms of pain."
< "Q5SSZ7-1","RefSeq","NP_001074393.1","30692207","Adrenocortical-specific loss of ZNRF3, but not RNF43, results in adrenal hyperplasia that depends on Porcupine-mediated Wnt ligand secretion."
< "Q5SSZ7-1","RefSeq","NP_001074393.1","29735715","XY mice lacking ZNRF3 exhibit complete or partial gonadal sex reversal, or related defects."
< "Q5SSZ7-1","RefSeq","NP_001074393.1","24349440","ZNRF3 binds RSPO1 and LGR5-RSPO1 with micromolar affinity via RSPO1 furin-like 1 (Fu1) domain. Publication Status: Online-Only"
< "Q5SSZ7-1","RefSeq","NP_001074393.1","22575959","Data suggest that R-spondin enhances Wnt signalling by inhibiting ZNRF3 Publication Status: Online-Only"
< "Q8C255-1","RefSeq","NP_001288133.1","12738806","Cloning and characterization of membrane-bound dipeptidase-2 and membrane-bound dipeptidase-3"
< "Q9EPU0-1","RefSeq","NP_001116301.1","29959727","Downregulation of UPF1 activated the TNFR1-dependent NF-kappaB/MAPKs pathway, and promoting inflammatory responses in colon might act as a causal role in Ulcerative Colitis."
< "Q9EPU0-1","RefSeq","NP_001116301.1","28128343","Status epilepticus led to increased protein levels of Up-frameshift suppressor 1 homolog (Upf1) within the mouse hippocampus. Upf1 protein levels were also higher in resected hippocampus from patients with intractable temporal lobe epilepsy. Publication Status: Online-Only"
< "Q9EPU0-1","RefSeq","NP_001116301.1","27149095","Upon removal of TDRD6, the association of several mRNAs with UPF1 and UPF2 is disturbed, and the long 3' UTR-stimulated but not the downstream exon-exon junction triggered pathway of NMD is impaired.This function depends on TDRD6-promoted assembly of mRNA and decay enzymes in Chromatoid bodies . Publication Status: Online-Only"
---
> "Q8R2R9-1","RefSeq","NP_083781.2","24923803","We have demonstrated genetic and alcohol-induced regulation of Ap3m2 expression. Although sequence analysis revealed no polymorphisms in the Ap3m2-coding region that could account for all phenotypic differences, there are several upstream SNPs that could."
> "P62983-1","RefSeq","NP_077239.1","22158882","Effector of HBx protein-mediated hepatocarcinogenesis"
1630a2299,2307
> "Q9R0C8-1","RefSeq","NP_666251.1","30450647","This study highlights Vav3 as a novel regulator of oligodendrocyte maturation and remyelination, suggesting that manipulation of the Vav3-dependent signaling pathway could help to improve myelin repair."
> "Q9R0C8-1","RefSeq","NP_666251.1","29858212","Inactivation of Vav3 in vivo resulted in increased vascular leakage, highlighting its function as a key regulator of barrier stability."
> "Q9R0C8-1","RefSeq","NP_666251.1","15365099","Three Vav proteins (vav1,vav2 and vav3) function specifically in distinct pathways that trigger NK cell cytotoxicity."
> "Q9R0C8-1","RefSeq","NP_666251.1","15249579","Vav1 and Vav3 proteins play an essential role coupling beta2 to Rho GTPases and regulating multiple integrin-induced events important in leukocyte adhesion and phagocytosis."
> "P40226-1","RefSeq","NP_033405.1","31301081","Study of hepatocarcinogenesis induced by diethylnitrosamine in B6C3F1 mice, the BrafV637E mutation, corresponding to the human BRAFV600E mutation, suggested that the TPO-mediated macroenvironmental changes involving the liver and bone marrow may promote proliferation of the BRAFV600E-mutated hepatocytes, but cause hematological, renal, and pulmonary disorders that lead to death."
> "Q8BIZ1-1","RefSeq","NP_852063.1","26085624","AIDA-1 regulates NMDAR subunit localization at synapses by facilitating transport of GluN2B."
> "Q8BIZ1-1","RefSeq","NP_852063.1","25457551","It induces PUMA protein activation, which involved in apoptosis."
> "Q8BIZ1-1","RefSeq","NP_852063.1","24636920","It inhibits Eg5, which reduces neurotrophin and neurotransmitter receptor function."
> "P47199-1","RefSeq","NP_034098.1","19657324","Induction of zeta-crystallin by an acid pH plays an important role in preventing BSC1 mRNA decay"
1641,1644c2318,2322
< "A4QPC6-1","RefSeq","NP_001276544.1","26809444","Btn2a2(-/-) mice exhibited enhanced effector CD4(+) and CD8(+) T cell responses, impaired CD4(+) regulatory T cell induction, potentiated antitumor responses, and exacerbated experimental autoimmune encephalomyelitis."
< "A4QPC6-1","RefSeq","NP_001276544.1","20208008","These data are consistent with a coinhibitory role for mouse Butyrophilins"
< "Q9CZ30-1","RefSeq","NP_080218.1","27481995","Data demonstrate that OLA1 is required for normal progression of mammalian development. OLA1 plays an important role in promoting cell proliferation at least in part through suppression of p21 and organogenesis via factors yet to be discovered. Publication Status: Online-Only"
< "Q9CZ30-1","RefSeq","NP_080218.1","26984302","Cell transformation induced by the metal mixture NaAsO2, CdCl2, and Pb(C2H3O2)2.3H2O through ROS generation was rescued by OLA1 knockdown during the initiation stage of morphological transformation."
---
> "Q64302-1","RefSeq","NP_032562.1","12855661","TAL6 may play a role in cancer invasion and metastasis"
> "Q3UMM4-1","RefSeq","NP_919428.1","28886341","CDK10 Mutations are associated with Severe Growth Retardation, Spine Malformations, and Developmental Delays."
> "Q3UMM4-1","RefSeq","NP_919428.1","22158035","Data indicate that peptidyl-prolyl isomerase Pin1(-/-) mouse embryonic fibroblasts (MEFs) showed higher cyclin-dependent kinase 10 (CDK10) expression than Pin1(+/+) MEFs."
> "Q3UMM4-1","RefSeq","NP_919428.1","16741970","Data show that murine cdk10 binds Ets2 transcription factors in vitro, does not show a direct involvement in the G2/M transition and, therefore, does not affect the proliferation rate of the cell lines analyzed."
> "Q3UMM4-1","RefSeq","NP_919428.1","8208557","Discusses PISSLRE, the human ortholog of mouse cyclin-dependent kinase 10."
1647a2326,2329
> "Q6P6N5-1","RefSeq","NP_891557.3","12646235","The finding of Spred-3 revealed the presence of a novel family of regulators for the Ras/MAP kinase pathway, each member of which may have different specificities for extracellular signals. [Spred-3]"
> "P25801-1","RefSeq","NP_001135809.1","29778661","Trichostatin A (TSA, a HDAC inhibitor) addition significantly attenuates MTX unsensitivity caused by dysfunction of LMO2/ZEB1 signaling. In conclusion, these findings have identified a molecular mechanism underlying LMO2/ZEB1-mediated leukaemogenesis, paving a way for treating T-ALL with a new strategy of epigenetic inhibitors."
> "P25801-1","RefSeq","NP_001135809.1","29880602","Transient LMO2 expression is sufficient for oncogenic function and induction of T-ALL. The resulting T-ALLs lacked LMO2 and its target-gene expression, and histologically, transcriptionally, and genetically similar to human LMO2-driven T-ALL."
> "P25801-1","RefSeq","NP_001135809.1","28973433","Genome-wide analysis indicated that LMO2 is required at the hemangioblast stage to position the TAL1/LMO2/LDB1 complex to regulatory elements that are important for the establishment of the hematopoietic developmental program."
1648a2331,2337
> "Q8BXL7-1","RefSeq","NP_083978.3","24186947","ARFRP1 and the Golgi apparatus play an important role in lipoprotein maturation in the liver."
> "Q8BXL7-1","RefSeq","NP_083978.3","22927645","Data indicate that ARFRP1 in the liver is involved in the regulation of IGF1 secretion and GLUT2 sorting and is thereby essential for normal growth and glycogen storage"
> "Q8BXL7-1","RefSeq","NP_083978.3","22505585","The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium."
> "Q8BXL7-1","RefSeq","NP_083978.3","20230794","Arfrp1 appears to be involved in sorting of GLUT4."
> "Q8BXL7-1","RefSeq","NP_083978.3","20038528","Lipid droplets of adipocytes of Arfrp1(-/-) mice were smaller and exhibited ultrastructural alterations, such as a disturbed interaction of small lipid particles with larger droplets."
> "Q8BXL7-1","RefSeq","NP_083978.3","18662990","ADP-ribosylation factor-like GTPase ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin."
> "Q8BXL7-1","RefSeq","NP_083978.3","18666447","This study provides the first detailed analysis of the regional distribution of ARFRP1 in the mouse brain and a quantitative view of its changes following sleep deprivation."
1650,1653d2338
< "Q9JHL0-1","RefSeq","NP_064428.1","25153696","NTAL is a negative regulator of FcepsilonRI activation events in murine bone marrow-derived mast cells, independently of possible compensatory developmental alterations. Publication Status: Online-Only"
< "Q9JHL0-1","RefSeq","NP_064428.1","24819605","Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation. Publication Status: Online-Only"
< "Q9JHL0-1","RefSeq","NP_064428.1","23675302","Our data define a novel link between LAB and beta-catenin nuclear accumulation in dendritic cells that facilitates IFN-gamma responses during anti-fungal immunity"
< "Q9JHL0-1","RefSeq","NP_064428.1","15477348","NTAL negatively regulates Fc-epsilon receptor I-mediated signaling events in bone marrow-derived mast cells."
1657d2341
< "O54834-1","RefSeq","NP_033837.2","11668396","Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice"
1662a2347,2350
> "Q5HZG9-1","RefSeq","NP_001013799.2","16908628","Zfp488 functions as an oligodendrocyte-specific transcription co-regulator important for oligodendrocyte maturation"
> "P28659-1","RefSeq","NP_941955.1","30158053","These results indicate that CELF1 target RNAs are aberrantly spliced in the Type 1 diabetic heart leading to abnormal gene expression."
> "P28659-1","RefSeq","NP_941955.1","28874395","Increased CELF1 expression down-regulates Cx43 mRNA level in the dilated cardiomyopathy heart."
> "P28659-1","RefSeq","NP_941955.1","28763438","LncBATE10 can decoy Celf1 from Pgc1alpha, thereby protecting Pgc1alpha mRNA from repression by Celf1 Publication Status: Online-Only"
1664a2353,2356
> "Q9R1K6-1","RefSeq","NP_035953.3","30975169","The Inhibition of GPR34-mediated signal by GPR34 gene deletion reduced nerve injury-induced neuropathic pain by suppressing pro-inflammatory responses of microglia without affecting their morphology. Publication Status: Online-Only"
> "Q9R1K6-1","RefSeq","NP_035953.3","26851221","Our study reveals a novel role of GPR34 in the fate of dendritic cells"
> "Q9R1K6-1","RefSeq","NP_035953.3","22343749","The present studies confirm that GPR34 is a cellular receptor for LysoPS, especially with a fatty acid at the sn-2 position."
> "Q9R1K6-1","RefSeq","NP_035953.3","21097509","GPR34-deficient mice showed significantly increased paw swelling in the delayed type hypersensitivity test and higher pathogen burden in extrapulmonary tissues after pulmonary infection with Cryptococcus neoformans compared with wild-type mice."
1694d2385
< "Q3UA16-1","RefSeq","NP_001186052.1","21084868","Spc25 is required for chromosome alignment, spindle formation, and proper spindle checkpoint signaling during meiosis."
1699a2391,2392
> "Q9WUH2-3","RefSeq","NP_034844.1","29565736","That Smurf1 promotes Lhx9 ubiquitylation and is involved in testosterone production in Leydig cells directly"
> "Q9WUH2-3","RefSeq","NP_034844.1","28456934","Lhx9 is a new molecular marker that defines a subset of amacrine cells and show that it is necessary for the development of the Nitric Oxide-Synthesizing Amacrine Cell subtype of amacrine cells."
1700a2394,2396
> "Q9D486-1","RefSeq","NP_083217.1","27650733","Unlike the human CMIP gene, only one Wt1 response element was identified in the mouse Cmip proximal promoter located at position -217/-206."
> "Q9D486-1","RefSeq","NP_083217.1","23200848","The c-mip protein is involve in regulating nephrin phosphorylation through Csk-Cbp/PAG-Fyn signaling pathway."
> "Q9D486-1","RefSeq","NP_083217.1","20808911","Expression of Cmip in the mouse hippocampus is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase). Publication Status: Online-Only"
1707,1712d2402
< "Q6P1G2-1","RefSeq","NP_001003953.1","29166607","Tthat bone morphogenetic protein (BMP) represses Oct4/Kdm2b-induced somatic reprogramming selectively"
< "Q6P1G2-1","RefSeq","NP_001003953.1","28319097","This study shows that long noncoding RNA Kdm2b expression sustains the maintenance of Innate lymphoid cells by promoting their proliferation through activation of the transcription factor Zfp292"
< "Q6P1G2-1","RefSeq","NP_001003953.1","24856970","Genetic ablation in embryonic stem cells reveal that deletion of PRC1 has genome-wide effects on PRC2 occupancy and H3K27me3; recognition of nonmethylated DNA by KDM2B, part of the PCGF1/PRC1 variant complex, is important for deposition of H2AK119ub1 and recruitment of PRC2 to a subset of CpG island targets and that this activity is essential for normal mouse development."
< "Q6P1G2-1","RefSeq","NP_001003953.1","21220025","Results suggest that the Fbxl10 gene makes important contributions to embryonic neural development by regulating cell proliferation and cell death in mice."
< "Q6P1G2-1","RefSeq","NP_001003953.1","18836456","Results indicate that Jhdm1b is an H3K36 demethylase that regulates cell proliferation and senescence through p15(Ink4b)."
< "Q6P1G2-1","RefSeq","NP_001003953.1","17296600","Study using a high throughput proteomics approach identified interactors with Rnf2 including Fbxl10/Jhdm1B, casein kinase subunits, and the BcoR corepressor"
1716a2407
> "Q3UPI1-1","RefSeq","NP_573450.2","18956345","Ened might be a novel target gene of the Fgfr signalling pathway during embryonic development"
1717a2409,2412
> "Q8K2W9-1","RefSeq","NP_083166.1","28230092","Rtfc (4931414P19Rik) regulates in vitro thyroid differentiation and in vivo thyroid function. Publication Status: Online-Only"
> "Q9CWR8-1","RefSeq","NP_062321.1","30321403","Our work uncovers a role for DNMT3L in maintaining DNMT3A stability, which contributes to the effect of DNMT3L on DNMT3A-dependent DNA methylation"
> "Q9CWR8-1","RefSeq","NP_062321.1","17060371","Sex-specific promoters control Dnmt3L expression in the mouse germ line, mirroring the situation at the Dnmt1 and Dnmt3A loci."
> "Q9CWR8-1","RefSeq","NP_062321.1","11719692","Likely to function not directly as a DNA methyltransferase but as a regulator of methylation at imprinted loci"
1720,1721c2415,2421
< "Q8CBW3-1","RefSeq","NP_001070658.1","30213875","This study shows that bone marrow-specific deletion of Abi1 in a novel mouse model leads to development of an myeloproliferative neoplasms-like phenotype resembling human primary myelofibrosis. Abi1 loss resulted in a significant increase in the activity of the Src family kinases (SFKs), STAT3, and NF-kappaB signaling."
< "Q8CBW3-1","RefSeq","NP_001070658.1","26428302","The expression of NESH/Abi-3 caused degradation of endogenous Abi-1, which led to the formation of a NESH/Abi-3-based WAVE2 complex. Publication Status: Online-Only"
---
> "Q9WUQ5-1","RefSeq","NP_062514.2","30958662","CXCL14 is expressed by islet delta-cells where it may have paracrine effects to inhibit insulin secretion in a CXCR4/CXCR7-independent manner through reductions in beta-cell ATP levels."
> "Q9WUQ5-1","RefSeq","NP_062514.2","30122557","The chemokine CXCL14 is secreted by brown fat in response to thermogenic activation. Brown-fat-secreted CXCL14 promotes the recruitment of M2-type macrophages. Lack of CXCL14 impairs brown fat activity and alters glucose homeostasis. CXCL14 induces browning of white fat via type 2 immune cells activation."
> "Q9WUQ5-1","RefSeq","NP_062514.2","28359053","Platelets are a relevant source of CXCL14. Platelet-derived CXCL14 at the site of vascular lesions might play an important role in vascular repair/regeneration."
> "Q3U1U7-1","RefSeq","NP_033774.1","29432714","Since AhRR knockdown increases the expression and activity of peroxisome proliferator-activated receptor gamma (PPARgamma), AhRR negatively regulates PPARgamma during adipogenesis"
> "Q3U1U7-1","RefSeq","NP_033774.1","27184933","These findings highlight the physiologic importance of cell-type specific balancing of AhR/AhRR expression in response to microbial, nutritional and other environmental stimuli. Specifically, AhRR contributes to the maintenance of colonic intraepithelial lymphocytes and prevents excessive IL-1beta production and Th17/Tc17 differentiation. In contrast, the AhRR enhances IFN-gamma-production by effector T cells in the in... Publication Status: Online-Only"
> "P54823-1","RefSeq","NP_851841.2","30044225","The Ddx6 knockout cells were phenotypically and molecularly similar to cells lacking all microRNAs (Dgcr8 knockout ESCs). These data show that the loss of DDX6 can separate the two canonical functions of microRNAs: translational repression and transcript destabilization Publication Status: Online-Only"
> "P54823-1","RefSeq","NP_851841.2","25722370","Data show that RNA helicase DDX6 colocalizes with ubiquitin-protein ligase TRIM32 in neural stem cells and neurons and that it increases the activity of microRNA Let-7a."
1722a2423,2427
> "P81615-1","RefSeq","NP_067265.1","28140406","Genetic deletion of Ucn1 reduced high levels of intake and preference across 2 weeks of continuous access drinking when alcohol concentrations were increased from 10 to 20 to 40%. Ucn1 deletion did not alter low-level drinking when the alcohol concentration remained at 10%. Publication Status: Online-Only"
> "P81615-1","RefSeq","NP_067265.1","27053649","Taken together, our data indicate that sex shows significant interaction with genotype and Ucn1 during colitis. Human duodenal and colonic biopsies revealed that sex-specific differences exist in levels of CRF receptors and Ucn1 expression in patients with CD compared with the matched non-IBD subjects. To conclude, Ucn1 mediates sex-specific immune and cellular signaling responses via CRF2, emphasizing the need for inclus"
> "P81615-1","RefSeq","NP_067265.1","25358399","This study aims to investigate the cellular localization of CRF and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation."
> "P81615-1","RefSeq","NP_067265.1","25473847","It is shown that CRH and UCN upregulate galectin-1 expression in Ishikawa cell line and macrophages and this effect is mediated through CRHR1. Publication Status: Online-Only"
> "P81615-1","RefSeq","NP_067265.1","12091910","Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior."
1724a2430,2435
> "Q9QY30-1","RefSeq","NP_066302.2","29850541","Studied effect of endotoxin exposure on liver following partial hepatectomy; found endotoxin exposure induced autoantibody production against Bsep (bile salt export pump) leading to dysfunction of hepatobiliary transporter systems. Publication Status: Online-Only"
> "Q9CQB7-1","RefSeq","NP_083886.1","26759027","Knockdown of LYRM1 induced mitochondrial impairment in P19 cells during differentiation, which was reflected by decreased ATP synthesis, lower MMP and increased ROS levels."
> "Q9CQB7-1","RefSeq","NP_083886.1","24771405","FCCP-induced mitochondrial dysfunction and insulin resistance are ameliorated by knockdown of LYRM1"
> "Q9CQB7-1","RefSeq","NP_083886.1","22820890","Alpha-LA protects 3T3-L1 adipocytes from LYRM1-induced insulin resistance partially via its capacity to restore mitochondrial function and/or increase phosphorylation of IRS-1 and Akt."
> "Q9CQB7-1","RefSeq","NP_083886.1","22249831","Knockdown of the Lyrm1 gene in adipocytes resulted in dramatically increased cellular ATP production, mitochondrial membrane potentials and levels Ucp2 mRNA, while ROS levels were significantly decreased."
> "Q9CQB7-1","RefSeq","NP_083886.1","22110480","Results suggest that the expression of LYRM1 mRNA is affected by a variety of factors that are related to insulin sensitivity; LYRM1 may be an important mediator in the development of obesity-related insulin resistance"
1727a2439
> "B3GLJ6-1","RefSeq","NP_001121982.1","18387948","Analysis of PATE, expressed primarily in prostate and less in testis, and additional PATE-like genes PATE-M, PATE-DJ, and PATE-B"
1736a2449,2452
> "Q925P2-1","RefSeq","NP_031569.1","27161904","Disruption of CEACAM2 induces a moderate integrin alphaIIbbeta3-mediated platelet function defect, and that CEACAM2 is essential to maintain a normal integrin alphaIIbbeta3-mediated platelet function."
> "Q925P2-1","RefSeq","NP_031569.1","26586918","CEACAM2 regulates insulin secretion, at least in part, by a GLP-1-mediated mechanism, independent of confounding metabolic factors."
> "Q925P2-1","RefSeq","NP_031569.1","25085348","Functional studies of platelets from Ceacam2(-/-)-deficient mice (Cc2(-/-)) revealed that CEACAM2 serves to negatively regulate collagen glycoprotein VI (platelet) (GPVI)-FcRgamma-chain and the C-type lectinlike receptor 2 (CLEC-2) signaling"
> "Q925P2-1","RefSeq","NP_031569.1","24948196","Sertoli cells recognize the excess cytoplasm of elongated spermatids through the PVR-CEACAM2-L interaction in mouse testis"
1764,1766d2479
< "Q30KP6-1","RefSeq","NP_001035116.1","26987518","Function in sperm maturation"
< "Q30KP6-1","RefSeq","NP_001035116.1","16023745","Defb41 and Defb42 are suggested to have a role in the antimicrobial protection of sperm and urogenital tract epithelia."
< "Q8R3P2-1","RefSeq","NP_001243025.1","16923970","Deltex can act as a negative regulator of Notch signals in T cells but that endogenous levels of Deltex1 and Deltex2 are not important for regulating Notch signals during thymocyte development"
1777a2491,2497
> "Q9Z2C6-1","RefSeq","NP_849255.2","11718558","Structure of the major membrane protein complex from urinary bladder epithelial cells by cryoelectron crystallography"
> "P97443-1","RefSeq","NP_033892.2","30061404","These findings provide functional evidence for a role of Smyd1, or any member of the Smyd family, in regulating cardiac energetics in the adult heart, which is mediated, at least in part, via modulating PGC-1alpha."
> "P97443-1","RefSeq","NP_033892.2","29499397","The data suggest that skNAC and Smyd1 might be major players in the processes of myofibrillogenesis and sarcomerogenesis, probably specifically at later stages."
> "P97443-1","RefSeq","NP_033892.2","27663768","Smyd1 is responsible for restricting growth in the adult heart, with its absence leading to cellular hypertrophy, organ remodeling, and fulminate heart failure. Molecular studies reveal Smyd1 to be a muscle-specific regulator of gene expression and indicate that Smyd1 modulates expression of gene isoforms whose expression is associated with cardiac pathology. Activation of Smyd1 can prevent pathological cell growth."
> "P97443-1","RefSeq","NP_033892.2","26935107","This work illustrates a crucial role for SMYD1 in skeletal muscle physiology and myofibril integrity."
> "P97443-1","RefSeq","NP_033892.2","12011100","Similar kinetics of induction and localization of m-Bop and skNAC during the induction of myogenesis in cultured C2C12 cells suggests a possible associated role for these proteins during this process."
> "P97443-1","RefSeq","NP_033892.2","11923873","Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis."
1779a2500
> "Q8K385-1","RefSeq","NP_033172.2","14499595","Data show that four members of the b561 family of predicted ferric reductases:  mouse cytochrome b561, human duodenal cytochrome b, and mouse stromal cell-derived receptor 2, have ferric reductase activity."
1784a2506
> "Q9CVB6-1","RefSeq","NP_083987.1","28827576","Study shows that the T-cell-specific deletion of Arpc2 results in compromised peripheral T-cell homeostasis suggesting that ARPC2 is essential for T-cell homeostasis probably by maintaining surface TCR levels via regulating TCR(+) endosome trafficking. Publication Status: Online-Only"
1800a2523,2541
> "Q65Z40-1","RefSeq","NP_001288259.1","29217590","The results demonstrate that the zygotic genome folds into loops and domains that critically depend on Scc1-cohesin and that are regulated in size and linear density by Wapl."
> "Q65Z40-1","RefSeq","NP_001288259.1","28424523","Distribution of cohesin in the mouse genome depends on transcription, CTCF and the cohesin release factor Wings apart-like (Wapl)"
> "Q65Z40-1","RefSeq","NP_001288259.1","27760328","NEK1 phosphorylates PP1gamma, leading to the dephosphorylation of WAPL, which, in turn, results in its retention on chromosome cores to promote loss of cohesion at the end of prophase I in mammals."
> "Q65Z40-1","RefSeq","NP_001288259.1","23975099","In mitosis, Wapl-mediated release of cohesin from DNA is essential for proper chromosome segregation and protects cohesin from cleavage by the protease separase, thus enabling mitotic exit in the presence of functional cohesin complexes"
> "Q65Z40-1","RefSeq","NP_001288259.1","15620708","MWAPL may be involved in spermatogenesis and be target genes mediating the reproductive toxicity induced by 2,3,7,8-trachlorodibenzo-p-dioxin ."
> "Q65Z40-1","RefSeq","NP_001288259.1","15150110","High levels of WAPAL are observed in human cervical cancers, and expression of human WAPAL in mice causes tumor formation."
> "O35182-1","RefSeq","NP_032568.3","26957275","A complex form of acute rheumatic heart disease with tissue hardening is seen in the absence of either Smad-6 (or NKX2-5)."
> "Q08943-1","RefSeq","NP_892035.2","30344095","It has been demonstrated that FACT potentiates H2A.X-dependent signaling of DNA damage."
> "Q08943-1","RefSeq","NP_892035.2","29953487","Uncovering the fine print of the CreERT2-LoxP system while generating a conditional knockout mouse model of Ssrp1 gene. Publication Status: Online-Only"
> "Q08943-1","RefSeq","NP_892035.2","26842758","FACT is required for TOP1 binding to H3K4me3 at non-B DNA containing chromatin for the site-specific cleavage. Publication Status: Online-Only"
> "Q9D956-1","RefSeq","NP_997612.2","20164257","MarvelD3, occludin, and tricellulin define the tight junction-associated MARVEL protein family"
> "Q61584-1","RefSeq","NP_032079.1","30803859","FXR deficiency increased hepatic steatosis and altered bile acid pool composition, contributing to worsened liver toxicity."
> "Q61584-1","RefSeq","NP_032079.1","30770808","Data show that recessive mutations in the particular exon of RNA binding proteins (FXR1P; FXR1) cause congenital multi-minicore myopathy in humans and mice. Publication Status: Online-Only"
> "Q61584-1","RefSeq","NP_032079.1","30397356","GUDCA was further identified as an intestinal FXR antagonist that improved various metabolic endpoints in mice with established obesity. Thus, we conclude that metformin acts in part through a B. fragilis-GUDCA-intestinal FXR axis to improve metabolic dysfunction, including hyperglycemia"
> "Q61584-1","RefSeq","NP_032079.1","29730159","FXR deficiency in hepatocytes might only play a minor role in alcoholic liver diseases (ALD) development. Deficiency of FXR in other non-hepatic tissues and/or increased bile acid levels resultant from whole-body FXR deficiency might be responsible for more severe ALD development."
> "Q61584-1","RefSeq","NP_032079.1","11178106","Four FXR1 isoforms of molecular weight 70, 74, 78, 80 kDa are widely distributed in mouse organs, while in striated muscles these isoforms are replaced by proteins of 82 and 84 kDa containing an extra pocket of 27 amino acids."
> "C0LLJ0-1","RefSeq","NP_001334460.1","28189564","A decreased H7N9 influenza A virus polymerase activity when importin-alpha7 was silenced by siRNA, is reported."
> "C0LLJ0-1","RefSeq","NP_001334460.1","20699224","Knocking out of Kpna7 induced abnormalities of gene expression (dppa2, dppa4, and piwil2) and epigenetic modifications (down-regulation of histone H3K27me3). Biochemical analysis showed that KPNA7 interacts with KPNB1 (importin-beta1)."
> "C0LLJ0-1","RefSeq","NP_001334460.1","20701745","A novel importin alpha family member with distinct subcellular localization and nuclear localization signal binding characteristics Publication Status: Online-Only"
1804a2546,2548
> "Q9ER69-1","RefSeq","NP_780603.1","29866655","WTAP, coupled with METTL3 and METTL14, is increased and distributed in nucleus by the induction of adipogenesis dependently on RNA in vitro knockdown of each of these three proteins leads to cell cycle arrest and impaired adipogenesis. Publication Status: Online-Only"
> "Q9ER69-1","RefSeq","NP_780603.1","26190105","Wtap is required for Xist-mediated silencing"
> "Q9ER69-1","RefSeq","NP_780603.1","18224709","Findings indicate that Wtap is indispensable for differentiation of mesoderm and endoderm in the mouse embryo"
1816,1818d2559
< "Q2TV84-1","RefSeq","NP_001034193.2","29854741","TRPM1 and mGluR6 are both essential components in the signaling pathway. Publication Status: Online-Only"
< "Q2TV84-1","RefSeq","NP_001034193.2","28899920","Results suggest that TRPM1 channel opening is essential for rod bipolar pathway establishment in development"
< "Q2TV84-1","RefSeq","NP_001034193.2","19966281","These results demonstrate that TRPM1-L is a component of the ON bipolar cell (BC) transduction channel downstream of mGluR6 in ON BCs."
1822,1824c2563,2566
< "Q9DCB1-1","RefSeq","NP_080398.1","26112184","Hmgn3 may play an important role during mouse decidualization."
< "Q9DCB1-1","RefSeq","NP_080398.1","23620591","Phenotypic analysis of Hmgn1(tm1/tm1), Hmgn3(tm1/tm1), and Hmgn5(tm1/tm1) mice and their wild type littermates with a battery of standardized tests uncovered variant-specific abnormalities."
< "Q9DCB1-1","RefSeq","NP_080398.1","15082770","Results suggest that HMGN3 regulates glycine transporter 1 expression and demonstrate that members of the HMGN family can regulate the transcription of specific genes"
---
> "Q8R2K4-1","RefSeq","NP_666204.2","19574399","Gonadotropin-releasing hormone-mediated phosphorylation of ERalpha in LbetaT2 pituitary cells results in its rapid association with p300-CBP-associated factor and the transcriptional activation of fosB."
> "Q9R0N3-1","RefSeq","NP_061274.2","30808661","Syt11 is an essential component of a neuronal vesicular trafficking pathway that differs from the well-characterized synaptic vesicle trafficking pathway but is also essential for life."
> "Q9R0N3-1","RefSeq","NP_061274.2","28686317","The results of this study proposed that Syt11 suppresses microglial activation under both physiological and pathological conditions through the inhibition of cytokine secretion and phagocytosis."
> "Q9R0N3-1","RefSeq","NP_061274.2","26450452","These results identify the lysosomes and Syt XI as the sub-cellular and molecular regulators, respectively of astrocyte cell membrane repair."
1825a2568,2572
> "P97325-1","RefSeq","NP_033202.3","25846372","St3gal2/3 double-null mice displayed dysmyelination marked by a reduction in major myelin proteins, fewer myelinated axons, a decrease in myelin thickness, possibly by dysregulation of ganglioside-mediated oligodendroglial precursor cell proliferation."
> "P97325-1","RefSeq","NP_033202.3","23830412","Knock-out mice have enhanced allergic eosinophilic airway inflammation"
> "P97325-1","RefSeq","NP_033202.3","23677475","These studies demonstrate that ST3Gal-III plays an important role in Siglec-F ligand formation and eosinophil apoptosis with resultant effects on eosinophilic inflammation in the lung."
> "P97325-1","RefSeq","NP_033202.3","23678987","MRNA levels of St3gal3 potentially involved in antithrombin sialylation, were 85% lower in neonates in comparison with adults. Publication Status: Online-Only"
> "P97325-1","RefSeq","NP_033202.3","12393657","Was not found to play a role in regulating synthesis of selectin ligands nor in vitro rolling of marrow-derived neutrophils on E- or P-selectins presented by Chinese hamster ovary cells"
1827,1828d2573
< "Q61411-1","RefSeq","NP_001123915.1","30655611","Study identifies WD40-repeat protein 76 (WDR76) as one of the HRAS binding proteins using proteomic analyses of hepatocellular carcinomas tissue form human patients and mouse diethylnitrosamine-induced liver carcinogenesis model and demonstrates that WDR76 functions as a tumor suppressor via RAS degradation. Publication Status: Online-Only"
< "Q61411-1","RefSeq","NP_001123915.1","29720552","Mice lacking R-Ras1 and/or R-Ras2 show a diminished oligodendrocytes population with a higher proportion of immature oligodendrocytes, explaining the observed hypomyelination"
1836a2582,2594
> "Q7TSZ8-1","RefSeq","NP_080064.3","28781078","NAC1 downregulates the E-cadherin repressor ZEB1 directly via transcriptional repression."
> "Q7TSZ8-1","RefSeq","NP_080064.3","28548937","Nac1 overexpression promotes ESC proliferation and delays ESC differentiation in the absence of leukemia inhibitory factor (LIF). Furthermore, we demonstrated that Nac1 directly binds to the c-Myc promoter and regulates c-Myc transcription."
> "Q7TSZ8-1","RefSeq","NP_080064.3","26832399","A sub-network of four factors, Nac1, Oct4, Tcf3, and Sox2, regulates mouse embryonic stem cell differentiation into the alternative mesendodermal and neuroectodermal fates."
> "Q7TSZ8-1","RefSeq","NP_080064.3","24702277","The interaction of Nac1 with Miz1 may thus be relevant to its mechanism of tumourigenesis in ovarian cancer. Publication Status: Online-Only"
> "Q7TSZ8-1","RefSeq","NP_080064.3","17945361","These data indicate involvement of NAC1 in the acute behavioral and neurochemical responses to psychomotor stimulants"
> "Q7TSZ8-1","RefSeq","NP_080064.3","14521994","The mouse Nac1 gene consist of six exons, with exon 2 containing an alternative splice donor, providing a molecular explanation of the splice variants observed in mouse and rat."
> "Q9CWR2-1","RefSeq","NP_081464.1","26908355","The transcription-potentiating function of Smyd3 is restricted to a particular set of genes."
> "Q9CWR2-1","RefSeq","NP_081464.1","25728514","Represent the proof of principle that SMYD3 is a druggable target"
> "Q9CWR2-1","RefSeq","NP_081464.1","25669152","Epigenetic control of Foxp3 by SMYD3 H3K4 histone methyltransferase controls iTreg development and regulates pathogenic T-cell responses during pulmonary viral infection."
> "Q9CWR2-1","RefSeq","NP_081464.1","25918436","These findings indicate that SMYD3 plays an important role in early embryonic lineage commitment and peri-implantation development through the activation of lineage-specific genes."
> "Q9CWR2-1","RefSeq","NP_081464.1","15235609","SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells."
> "Q8K0T0-1","RefSeq","NP_703187.2","29167231","Reticulon-1 is responsible for reduced chemotaxis of macrophages differentiated from the one bone marrow of ultraviolet-irradiated and ultraviolet-chimeric mice"
> "Q8K0T0-1","RefSeq","NP_703187.2","28336924","These data suggest that endoplasmic reticulum stress plays a major role in podocyte injury in diabetic nephropathy and RTN1A might be a key regulator of reticulum stress stress in podocytes. Publication Status: Online-Only"
1847a2606
> "O08810-1","RefSeq","NP_035561.1","24361939","Eftud2 regulates alternative splicing of MyD88 to control the innate immune response in macrophages"
1859,1860c2618
< "Q921U8-1","RefSeq","NP_001271356.1","18678771","Smoothelins as key determinants of arterial smooth muscle contractility and cardiovascular performance"
< "Q921U8-1","RefSeq","NP_001271356.1","16285958","Smoothelin-A is essential for functional contractility of intestinal smooth muscle."
---
> "Q9D410-1","RefSeq","NP_001136163.1","17660561","Transcripts highly enriched in ovary; gene identified as candidate female fertility factor."
1868,1869c2626,2633
< "Q8VCF1-1","RefSeq","NP_001020788.1","28330694","CANT1 long non-coding RNA triggers efficient therapeutic efficacy by correcting aberrant long non-coding cascade in malignant uveal melanoma."
< "Q8VCF1-1","RefSeq","NP_001020788.1","22451650","Restoring CANT1 levels in neuroblastoma clones recovered the phenotype, thus confirming a key role of CANT1, and of the regulation of its gene by DREAM, in the control of protein synthesis and degradation"
---
> "Q8BXK8-1","RefSeq","NP_835220.1","22453919","GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity."
> "Q8BXK8-1","RefSeq","NP_835220.1","20664521","The elimination of adaptor protein 3 or abrogation of AGAP1-M5 muscarinic receptor interaction in vivo decreased the magnitude of presynaptic M5 muscarinic receptor mediated dopamine release potentiation in the striatum."
> "Q8BXK8-1","RefSeq","NP_835220.1","15381706","AGAP1 is a novel binding partner of nitric oxide-sensitive guanylyl cyclase"
> "Q8K467-1","RefSeq","NP_666372.1","25467981","This study demonistrated that TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells."
> "Q8K467-1","RefSeq","NP_666372.1","23582420","Tmie is required for maturation and maintenance of hair cells."
> "Q8K467-1","RefSeq","NP_666372.1","18586001","These results clearly indicate that tmie protein plays an important role when the appropriate expression level of tmie was expressed in the inner ear."
> "Q8K467-1","RefSeq","NP_666372.1","17219777","Characterized the circling mutation as a 40-kilobase deletion that includes the transmembrane inner ear (tmie) gene"
> "Q8K467-1","RefSeq","NP_666372.1","12140191","Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6."
1872a2637,2638
> "Q8R0S4-3","RefSeq","NP_666235.1","27003325","Study demonstrates that the lack of the voltage-gated calcium channel beta4 subunit causes a decreased late development in cerebellar cortical networks, characterized by reduced parallel fibre-purkinje cell input, shorter purkinje cell dendrites and depressed purkinje cell output."
> "Q8R0S4-3","RefSeq","NP_666235.1","24875574","The nuclear targeting properties of the truncated beta(4b(1-481)) subunit in tsA-201 cells, skeletal myotubes, and in hippocampal neurons, were investigated."
1878,1879d2643
< "Q60954-1","RefSeq","NP_001180200.1","29592525","Meis1 is specifically expressed in stroma and myofibroblasts of mouse. It is not required for kidney development, disease, or aging."
< "Q60954-1","RefSeq","NP_001180200.1","29719258","PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21."
1883a2648,2649
> "P61600-1","RefSeq","NP_080701.1","22101279","Mdm20 is not necessarily co-expressed with Nat5 in the developing mouse brain."
> "P61600-1","RefSeq","NP_080701.1","20145209","ARD1 functions as an inhibitor of the mTOR pathway and that dysregulation of the ARD1-TSC2-mTOR axis may contribute to cancer development Publication Status: Online-Only"
1887a2654,2657
> "P14824-1","RefSeq","NP_038500.2","30110341","AnxA6 contributing to the fine-tuning of hepatic glucose metabolism with potential consequences for the systemic control of glucose in health and disease. Publication Status: Online-Only"
> "P14824-1","RefSeq","NP_038500.2","29921656","Annexin A6-deficient mice showed increased sensitivity to mechanical stimuli, overexpression of annexin A6 in sensory neurons attenuated mechanical pain in a mouse model of osteoarthritis Publication Status: Online-Only"
> "P14824-1","RefSeq","NP_038500.2","29771996","Findings define a novel role for AnxA6 in articular chondrocytes via its modulation of Wnt/beta-catenin and NF- kappaB signaling activities and the cross-talk between these two signaling pathways. Publication Status: Online-Only"
> "P14824-1","RefSeq","NP_038500.2","28712927","Morphological analysis of liver sections from annexin A6-KO mice revealed significantly lower lipid droplet numbers compared to wildtype animals"
1906d2675
< "A8Y5H7-1","RefSeq","NP_001159978.1","15531584","The Sec14 domain regulates Dbs transformation through at least two distinct mechanisms, neither of which appears to directly influence the in vivo exchange activity of the protein"
1912c2681,2683
< "Q3U3C9-1","RefSeq","NP_001139368.1","16169686","Some mKIAA genes are apparently relevant to retinoic acid-induced neurite outgrowth. (mKIAA gene)"
---
> "P60670-1","RefSeq","NP_955763.1","26112410","The study revealed a regulatory role of the p97-Npl4-Ufd1 complex in regulating a partial degradation of the NF-kappaB subunit p100."
> "P60670-1","RefSeq","NP_955763.1","17491009","Structural analysis of the p97-Npl4-Ufd1 interface"
> "P60670-1","RefSeq","NP_955763.1","16103111","The p97-Ufd1-Npl4 complex couples ubiquitinated IP(3) receptors to proteasomal degradation and, thus, plays a key role in IP(3) receptor processing"
1934a2706
> "Q01237-1","RefSeq","NP_032281.2","30354246","Myeloid cell Hmgcr drives atherosclerosis by promoting macrophage migration."
1939,1942c2711,2712
< "Q62315-1","RefSeq","NP_001191972.1","30700554","This study demonstrates that ablation of Jarid2 in cardiomyocytes results in dilated cardiomyopathy and suggest that Jarid2 plays important roles in cardiomyocyte maturation during neonatal stages."
< "Q62315-1","RefSeq","NP_001191972.1","30423295","In this study, genetic mouse models and patient-derived xenografts demonstrated that JARID2 acts as a tumor suppressor in chronic myeloid disorders."
< "Q62315-1","RefSeq","NP_001191972.1","30119689","JARID2 regulates muscle differentiation by modulating Wnt signaling through direct repression of SFRP1. Publication Status: Online-Only"
< "Q62315-1","RefSeq","NP_001191972.1","29891551","The deletion of Jarid2 by Nkx2.5-Cre mice (Jarid2(Nkx)) caused cardiac malformations including ventricular septal defects, thin myocardium, hypertrabeculation, and neonatal lethality. Jarid2(Nkx) mice exhibited elevated expression of neural genes, cardiac jelly, and other key factors including Isl1 and Bmp10 in the developing heart."
---
> "Q8BTY1-1","RefSeq","NP_765992.2","28097769","One is the native structure with the cofactor in the PLP form bound to Lys247 with the highest resolution yet available for KAT-I at 1.28 A resolution, and the other with the general PLP-dependent aminotransferase inhibitor, aminooxyacetate (AOAA) covalently bound to the cofactor at 1.54 A."
> "Q8BTY1-1","RefSeq","NP_765992.2","20482848","KAT I inhibited by equimolar tryptophan and half-life is 69.7 minutes at 65 degree C. Publication Status: Online-Only"
1958a2729,2731
> "Q149L0-1","RefSeq","NP_082066.2","29106393","Low DHRS2 expression promotes esophageal squamous cell carcinoma."
> "Q149L0-1","RefSeq","NP_082066.2","23036705","M. musculus DHRS2 and DHRS4 genes are syntenic outparalogs that originated from a duplication of the DHRS4 gene that took place before the formation of the mammalian clade. M. musculus genes are orthologs of human DHRS2 and DHRS4 genes respectively."
> "Q149L0-1","RefSeq","NP_082066.2","16685466","Functional analysis of the human Dhrs2 ortholog."
1961a2735,2743
> "P61021-1","RefSeq","NP_803130.1","26399387","Clear effect of subcutaneous zoledronic acid administration in vivo on the prenylation of Rab1A, Rab5B, Rab7A and Rab14 in mouse peritoneal macrophages, confirming that systemic treatment with bisphosphonate drug can inhibit prenylation in myeloid cells in vivo outside the skeleton."
> "Q8K4K6-1","RefSeq","NP_076281.1","26549575","Pank1 genetic deficiency can be corrected using phosphopantothenate diet replacement therapy."
> "Q8K4K6-1","RefSeq","NP_076281.1","24781151","The results indicate that Pank1 deficiency drives a whole-body metabolic adaptation that improves aspects of the diabetic phenotype and uncouples hyperglycaemia and hyperinsulinaemia from obesity in leptin-deficient mice."
> "Q8K4K6-1","RefSeq","NP_076281.1","23343762","P53 plays an important role in regulating energy homeostasis through transcriptional control of PANK1."
> "Q8K4K6-1","RefSeq","NP_076281.1","20559429","Data illustrate the importance of PanK1 and elevated liver CoA levels during fasting to support the metabolic transition from glucose utilization and fatty acid synthesis to gluconeogenesis and fatty acid oxidation Publication Status: Online-Only"
> "E9Q4Z2-1","RefSeq","NP_598665.2","30018077","AMPK-ACC signaling is coupled to the control of thrombosis by specifically modulating thromboxane and granule release in response to collagen."
> "E9Q4Z2-1","RefSeq","NP_598665.2","29931154","Findings suggest that ACC2 deletion leads to intramyocellular lipid reduction without suppressing glucose use via an elevation in acetyl-CoA metabolism even under high-fat diet conditions and offer new mechanistic insight into the therapeutic potential of ACC2 inhibition on insulin resistance."
> "E9Q4Z2-1","RefSeq","NP_598665.2","15677334","Fatty acid oxidation in the adipocytes of Acc2-/- mutant mice, combined with a higher level of glucose oxidation and a higher rate of lipolysis, are major factors leading to efficient maintenance of insulin sensitivity and leaner Acc2-/- mutant mice."
> "E9Q4Z2-1","RefSeq","NP_598665.2","12920182","ACC2 plays an essential role in controlling fatty acid oxidation and is a potential target in therapy against obesity and related diseases."
1962a2745,2746
> "Q9D700-1","RefSeq","NP_080145.1","26247726","DUSP26 down-regulation is an effective antineoplastic neuroblastoma strategy through activation of the p53 and p38 MAPK tumor-suppressor pathways. Publication Status: Online-Only"
> "Q9D700-1","RefSeq","NP_080145.1","24548998","Results suggest that AK2 is an associated activator of DUSP26 and suppresses cell proliferation by FADD dephosphorylation, postulating AK2 as a negative regulator of tumour growth."
1963a2748
> "Q4TU90-1","RefSeq","NP_918952.2","25790000","The Rhox3 shRNA causes spermatogenic defects by sequestering one or more components of the endogenous small RNA biogenesis machinery. Publication Status: Online-Only"
1966a2752,2753
> "Q91YT8-1","RefSeq","NP_659043.1","27045885","TMEM63 proteins may serve as an osmolarity sensitive ion channel for the osmoreception."
> "Q3UVR3-1","RefSeq","NP_542966.2","23141541","Study shows that TTBK2 is a dedicated regulator of the initiation of ciliogenesis in vivo; TTBK2 acts at the distal end of the basal body, where it promotes the removal of CP110, which caps the mother centriole, and promotes recruitment of intraflagellar transport proteins."
1984a2772,2776
> "P21447-1","RefSeq","NP_035206.2","30942458","WYE354 stimulated the ATPase activity of ABCB1, which was consistent with in silico predictions using a human ABCB1 mouse homology model, indicating that WYE354 is a potent substrate of ABCB1."
> "P21447-1","RefSeq","NP_035206.2","29499278","The activation of P-Glycoprotein, Abcb1a, -mediated ATP hydrolysis by methadone was monophasic, whereas loperamide activation of ATP hydrolysis was biphasic implying methadone has a single binding site and loperamide has 2 binding sites on P-gp."
> "Q9D541-1","RefSeq","NP_083337.1","25706396","Silencing Biot2 in CT26 cells by RNA interference can inhibit cell growth in vitro and in vivo."
> "Q9D541-1","RefSeq","NP_083337.1","19950598","Biot2-L was highly expressed in adult testis, and its expression increased regularly during testis development."
> "Q9D541-1","RefSeq","NP_083337.1","19277478","The Biot2 transcript was detected only and strongly in the testis tissues and abundantly in five types of murine cancer cell line."
1988a2781,2785
> "Q9D2P8-1","RefSeq","NP_032640.1","26801084","MOBP synthesis is stimulated by Fyn activity."
> "O88665-1","RefSeq","NP_036177.1","29127434","A novel basis for understanding the molecular dynamics of glucose metabolism and the unique function of BRD7 in the regulation of glucose homeostasis."
> "O88665-1","RefSeq","NP_036177.1","29273506","Furthermore, Brd7 inhibition alters the phenotype of macrophages and promotes plaque instability, at least partly via STAT6 signaling. Our data define a previously undescribed role of Brd7 in the development of atherosclerosis."
> "O88665-1","RefSeq","NP_036177.1","27374794","These findings suggest that BRD7 has an anti-inflammatory role during early acute inflammation by inhibiting activation of the NF-small ka, CyrillicB signaling pathway, which provides evidence to aid in understanding the therapeutic effects of BRD7 on inflammatory diseases"
> "O88665-1","RefSeq","NP_036177.1","27444544","Homozygous BRD7 knockout (KO) mice showed retardation in development. Erratum:[J Cell Mol Med. 2017 Jun;21(6):1243. PMID: 28504477]"
1993a2791,2792
> "F8VPK8-1","RefSeq","NP_001074846.1","25802080","Quantitative analysis of basic mouse behavior uncovered a role for Pcdh9 in specific cognitive functions required for long-term recognition, involvement of Pcdh9 in sensory cortex development and showed effect of its deletion on sensorimotor behaviors"
> "F8VPK8-1","RefSeq","NP_001074846.1","22982106","The results of this study demonistrated that the distribution of Pcdh9 protein in the olfactory bulb, retina, spinal cord, and dorsal root ganglion"
1996a2796,2798
> "Q80U72-1","RefSeq","NP_598850.1","30083817","Scribdeficient hematopoietic stem cells reveal impaired migratory capacity."
> "Q80U72-1","RefSeq","NP_598850.1","12499390","Scrb1, encodes a member of the LAP protein family related to Drosophila scribble.Disruption of scribble (Scrb1) gene causes severe neural tube defects in the circletail mouse"
> "Q80U72-1","RefSeq","NP_598850.1","12112872","Heterozygotes are incompletely penetrant for a circled-tail phenotype, while homozygotes die at birth of a severe neural tube defect."
1997a2800,2802
> "P09581-1","RefSeq","NP_001032948.2","30767584","In ovarian follicles, following the luteinizing hormone surge, levels of MCSF and MCSF receptor decrease"
> "Q3UV70-1","RefSeq","NP_001277320.1","27538372","Mitochondrial PDP1 is a potential regulator that controls cardiac differentiation at an early differentiation stage in mouse embryonic stem cells. Publication Status: Online-Only"
> "Q3UV70-1","RefSeq","NP_001277320.1","19411760","Defects in PP2Cm may be responsible for a subset of human maple syrup urine disease"
2006a2812,2815
> "Q6P5G0-1","RefSeq","NP_766220.2","25002529","Results uncover a unique role for ERK3, dependent on its kinase activity, during T cell development and show that this atypical MAPK is essential to sustain CD4(+) CD8(+) (DP) thymocytes survival during RAG-mediated rearrangements."
> "Q6P5G0-1","RefSeq","NP_766220.2","24475167","The atypical MAPK ERK3 is a new and important regulator of T cell receptor-induced T cell activation. Erratum:[PLoS One. 2014;9(8):e104727] Publication Status: Online-Only"
> "Q6P5G0-1","RefSeq","NP_766220.2","20956558","Data suggest that Erk4 is dispensable for mouse embryonic development and reveals that Erk3 and Erk4 have acquired specialized functions through evolutionary diversification."
> "Q6P5G0-1","RefSeq","NP_766220.2","16973613","Data show that in contrast to ERK3, ERK4 (MAPK4) is a stable protein and binds to MAPKAPK-5. Interaction of ERK4 with MAPKAPK-5 leads to translocation of MAPKAPK-5 to the cytoplasm and to its activation by phosphorylation. ERK4 can form dimers with ERK3."
2023a2833,2835
> "Q99M80-1","RefSeq","NP_067439.1","24895325","Receptor protein tyrosine phosphatase rho (RPTPrho, gene symbol PTPRT) is a transmembrane protein expressed at high levels in the developing hippocampus, olfactory bulb, cortex, and cerebellum."
> "Q99M80-1","RefSeq","NP_067439.1","24949727","These studies implicate PTPRT-modulated STAT3 signaling in the regulation of high-fat diet-induced obesity Publication Status: Online-Only"
> "Q99M80-1","RefSeq","NP_067439.1","22767509","BCR is a novel substrate of PTPRT ."
2031,2035c2843,2846
< "Q3U0P1-1","RefSeq","NP_001074707.1","29739757","The tumor suppression mechanisms of the BRCA1-PALB2 DNA damage response pathway."
< "Q3U0P1-1","RefSeq","NP_001074707.1","28240985","The findings demonstrate that RNF168 couples PALB2-dependent homologous recombination to H2A ubiquitylation to promote DNA repair and preserve genome integrity. Publication Status: Online-Only"
< "Q3U0P1-1","RefSeq","NP_001074707.1","20484223","A key function for PALB2 is to interact with and to build up appropriate communication between BRCA1 and BRCA2."
< "P58659-1","RefSeq","NP_001186139.1","25122090","We demonstrate that MADD-4 interacts with an EVA-1/UNC-40 co-receptor complex to attract cell extensions Publication Status: Online-Only"
< "P58659-1","RefSeq","NP_001186139.1","24040182","We report that EVA1C is expressed by axons contributing to commissures, tracts and nerve pathways of the developing spinal cord and forebrain. Publication Status: Online-Only"
---
> "Q3UEG6-1","RefSeq","NP_001297665.1","27752141","This study shows that diabetes-linked transcription factor HNF4alpha regulates maminotransferase 2etabolism of endogenous methylarginines and beta-aminoisobutyric acid by controlling expression of alanine-glyoxylate Publication Status: Online-Only"
> "Q3UEG6-1","RefSeq","NP_001297665.1","27752063","We experimentally proved the presence of a new pathway of homoarginine catabolism - its transamination by AGXT2 with formation of GOCA and demonstrated that endogenous AGXT2 is required for maintenance of homoarginine levels in mice. Publication Status: Online-Only"
> "Q3UEG6-1","RefSeq","NP_001297665.1","23280748","In this work, we describe an assay for the AGXT2 activity in mouse liver and kidney tissue. The overall production rates of DMGV-d(6) in mice were 195.37 pmol/min/mg total protein in liver and 85.21 pmol/min/mg total protein in kidney tissue."
> "Q3UEG6-1","RefSeq","NP_001297665.1","23023372","Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure."
2053a2865,2867
> "Q4VBE4-1","RefSeq","NP_848863.1","26091521","Pikachurin Protein Required for Increase of Cone Electroretinogram B-Wave during Light Adaptation Publication Status: Online-Only"
> "Q4VBE4-1","RefSeq","NP_848863.1","21129441","These results indicate that pikachurin interactions with alpha-dystroglycan and its localization at the photoreceptor ribbon synapse require normal glycosylation of alpha-dystroglycan."
> "Q4VBE4-1","RefSeq","NP_848863.1","20682766","Post-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization."
2059a2874,2879
> "Q91VU0-1","RefSeq","NP_613053.3","29871931","ILEI contributes to melanoma cell invasiveness in vivo without affecting primary tumor growth and is transcriptionally up-regulated by USF-1."
> "Q91VU0-1","RefSeq","NP_613053.3","28751379","Data suggest that Ilei does not form interleukin-like four helix-bundle structures; Ilei exists as monomers and as covalent dimers; Ilei dimer exhibits a trans-linked domain swap converting an intramolecular disulfide to an intermolecular disulfide; dimeric Ilei appears to be involved in neoplastic invasiveness."
> "Q91VU0-1","RefSeq","NP_613053.3","28246289","In obese diabetic mice, FAM3C expression was reduced in the liver, and hepatic FAM3C restoration improved insulin resistance, hyperglycemia, and fatty liver. FAM3C overexpression increased the expression of heat shock factor 1 (HSF1), calmodulin (CaM), and phosphorylated Akt and reduced that of gluconeogenic and lipogenic genes in diabetic mouse livers with the suppression of gluconeogenesis and lipid deposition."
> "Q91VU0-1","RefSeq","NP_613053.3","27914282","Overexpression of Fam3c caused reduction of Runx2 expression at both mRNA and protein levels. Fam3c was localized in the cytoplasm and it was not secreted outside the cell during osteoblast differentiation and therefore, may function intracellularly. Furthermore, Fam3c and TGF-beta1 were found to regulate each other reciprocally"
> "Q91VU0-1","RefSeq","NP_613053.3","27256505","Study used immunohistochemical staining and biochemical fractionation to examine the regional distribution and subcellular localization of ILEI in mouse brains and in autopsy brains of patients with Alzheimer's disease; results suggest that a decline of ILEI expression may cause accumulation of Abeta in the brain and the eventual development of Alzheimer's disease."
> "Q91VU0-1","RefSeq","NP_613053.3","15194199","FAM3C orthologous protein, may be involved in cell differentiation and proliferation during inner ear embryogenesis"
2078a2899
> "P48346-1","RefSeq","NP_032383.1","30587590","IL-15 is a component of the inflammatory milieu in the tumor microenvironment promoting antitumor responses."
2079a2901,2902
> "Q8VHI6-1","RefSeq","NP_660137.1","28794159","P63alpha protein up-regulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion"
> "Q8VHI6-1","RefSeq","NP_660137.1","12185600","WAVE3 transcript is mainly expressed in the nervous system and, like all the members of the WASP gene family, WAVE3 is a key element in actin polymerization and cytoskeleton organization."
2080a2904,2907
> "O54689-1","RefSeq","NP_033965.1","29695802","Obesity-induced IL-6 shifts macrophage polarization towards tumor-promoting macrophages that produce the CCL-20 in the colitis-associated colorectal cancer (CAC) microenvironment. CCL-20 promotes CAC progression by recruiting CCR6-expressing B-cells and gammadelta T cells via chemotaxis. Publication Status: Online-Only"
> "O54689-1","RefSeq","NP_033965.1","29097259","CCR6 facilitates tumor angiogenesis via the AKT/NF-kappaB/VEGF pathway in colorectal cancer"
> "O54689-1","RefSeq","NP_033965.1","29262350","CCR6 defines memory B cell precursors in mouse and human germinal centers, revealing light-zone location and predominant low antigen affinity."
> "O54689-1","RefSeq","NP_033965.1","9862452","This gene is a mouse CC chemokine receptor CCR6 but not carbon catabolite repression 6. The definition line of the GenBank file (AB009639) has been corrected as G protein-coupled receptor."
2081a2909,2915
> "Q9JKL1-1","RefSeq","NP_067356.2","30253862","The study shows that PK2beta ligand, a splice variant of prokineticin 2, is able to modulate and drive signaling through prokineticin receptor 1."
> "Q9JKL1-1","RefSeq","NP_067356.2","29038558","Upon high fat diet exposure, PKR1 (tcf-/-) mice displayed excessive fat deposition in the atrioventricular groove, perivascular area, and pericardium, which was accompanied by an impaired vascular network and cardiac dysfunction. Publication Status: Online-Only"
> "Q9JKL1-1","RefSeq","NP_067356.2","27084889","These results establish PKR1 via NFATc3 as a crucial modifier of mesenchymal-epithelial transition processing to the development of nephron."
> "Q9JKL1-1","RefSeq","NP_067356.2","27150455","The authors discovered that PKR1 regulates epicardial-mesenchymal transition (EMT) for epicardial-derived progenitor cell (EPDC), formation. This event affects at least three consequential steps during heart development: (i) EPDC and cardiomyocyte proliferation involved in thickening of an outer compact ventricular chamber wall, (ii) rhythmicity, (iii) formation of coronary circulation. Publication Status: Online-Only"
> "Q9JKL1-1","RefSeq","NP_067356.2","26829592","Show that MRAP2 significantly and specifically inhibits PKR1 signaling. Publication Status: Online-Only"
> "Q8BM11-1","RefSeq","NP_808394.1","23331848","TG6 is an active enzyme and reacts to glutamine donor substrates in the skin."
> "Q8BM11-1","RefSeq","NP_808394.1","21984379","Localization of mRNA and protein in the mouse identified abundant expression of TG6 in the central nervous system."
2100a2935,2936
> "O09012-1","RefSeq","NP_787947.1","26086376","Monoubiquitination of the N-terminal cysteine of peroxisome-associated PEX5 not only functions to recycle the peroxin back to the cytosol, but also serves as a quality control mechanism to eliminate peroxisomes with a defective protein import machinery"
> "O09012-1","RefSeq","NP_787947.1","22458306","Demyelination in cerebellum and brain stem preceded major myelin loss in corpus callosum of Pex5 deficient mice. Publication Status: Online-Only"
2108,2110c2944,2947
< "O54931-1","RefSeq","NP_001030610.1","26432469","Knocking down akap2 expression remarkably decreased tumorigenicity and metastatic ability of prostate cancer cells. AKAP2 may serve as a critical component of Calcitonin receptor-mediated oncogenic actions."
< "O54931-1","RefSeq","NP_001030610.1","22095752","The AKAP2 protein is direct phosphorylation within a regulatory region of aquaporin-0 to modulate water permeability."
< "O54931-1","RefSeq","NP_001030610.1","16260760","Distinct modes of AKAP binding may contribute to the more discriminating nature of the RIalpha (protein kinase A isoform) and AKAP docking surface"
---
> "Q9D7P9-1","RefSeq","NP_082247.1","26220980","Data suggest that SERPINB12, like some other intracellular serpins, may play a vital role in barrier function by providing protection of epithelial cells."
> "Q3V3R1-1","RefSeq","NP_758512.3","29483189","This study performed untargeted metabolomics on whole Mthfd1l-null and wildtype mouse embryos in combination with isotope tracer analysis in mouse embryonic fibroblast cell lines to identify Mthfd1l deletion-induced disruptions in 1-carbon metabolism, glycolysis, and the TCA cycle. Mthfd1l-null fibroblasts have altered methionine synthesis, indicating that Mthfd1l deletion impairs the methyl cycle."
> "Q3V3R1-1","RefSeq","NP_758512.3","23267094","Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice."
> "Q3V3R1-1","RefSeq","NP_758512.3","19948730","Data show that the MTHFD1L enzyme is present in mitochondria from normal embryonic tissues and embryonic fibroblast cell lines, and embryonic mitochondria possess the ability to synthesize formate from glycine."
2112a2950,2957
> "Q9ERZ4-1","RefSeq","NP_987076.2","30102779","Synaptic enrichment in M2R density may reflect a compensatory mechanism activated in tibialis anterior and Soleus motor neurons to different extent in response to reduced strength of cholinergic signaling"
> "Q9ERZ4-1","RefSeq","NP_987076.2","29740092","The conjugated bile acids were found to be partial agonists of the muscarinic M2, but not sphingosin-1-phosphate-2, receptors, and act partially through the Gi pathway. Furthermore, the contraction slowing effect of unconjugated bile acids may also relate to cytotoxicity at higher concentrations Publication Status: Online-Only"
> "Q9ERZ4-1","RefSeq","NP_987076.2","29563233","M2 receptors promote arginine-vasopressin synthesis in the supraoptic nuclei and play a role in the regulation and maintenance of body fluid."
> "Q8R081-1","RefSeq","NP_796275.3","27271479","Data suggest that hnRNP L is critical for the survival and functional integrity of HSCs by restricting the activation of caspase-dependent death receptor pathways Publication Status: Online-Only"
> "Q8R081-1","RefSeq","NP_796275.3","26904944","LncLGR facilitates the recruitment of hnRNPL to the GCK promoter and suppresses GCK transcription."
> "Q8R081-1","RefSeq","NP_796275.3","25936916","Hnrnpl binds to p53 and inhibits its activation in mouse embryonic stem cells."
> "Q8R081-1","RefSeq","NP_796275.3","24434558","Aire-containing complexes include 7SK RNA, the latter interaction disrupted by HNRNPL knockdown, suggesting that HNRNPL may partake in delivering inactive P-TEFb to Aire"
> "Q8R081-1","RefSeq","NP_796275.3","12130696","Inflammation modulates the interaction of hnRNP I and hnRNP L with the 3'untranslated region of the murine inducible nitric-oxide synthase mRNA"
2120c2965,2967
< "Q9R0H0-1","RefSeq","NP_001258827.1","30312667","Study describes an Acox1-deficient cell line presenting the main biochemical characteristics of severe peroxisomal leukodystrophy and will serve as a promising model to further investigate the consequences of a specific microglial peroxisomal beta-oxidation defect on oxidative stress, inflammation and cellular functions."
---
> "Q62447-1","RefSeq","NP_058026.2","30516433","Cyclin C binding stimulates the reduction of low-GTPase activity Drp1 oligomers into dimers capable of producing high-GTPase activity filaments."
> "Q62447-1","RefSeq","NP_058026.2","28351837","These data indicate that CycC activates adipogenesis in part by stimulating the transcriptional activity of C/EBPalpha."
> "Q62447-1","RefSeq","NP_058026.2","26042770","Our results suggest that mTORC1 activation in NAFLD and insulin resistance results in down-regulation of the CDK8-CycC complex and elevation of lipogenic protein expression. Publication Status: Online-Only"
2126a2974,2975
> "Q8BWB1-1","RefSeq","NP_780341.1","21948713","Analysis of CHAP expression in mouse during embryonic and adult stages; CHAP is expressed in the developing heart and somites, as well as muscle precursors of the limb buds in mouse and chick embryos"
> "Q8BWB1-1","RefSeq","NP_780341.1","20215401","Essential for heart and skeletal muscle function GeneRIF: Cloning and characterization of CHAP, both a sarcomeric and nuclear protein which is essential for striated muscle development and function. Two isoforms are described: ChapA is predominantly expressed in adult muscle and ChapB in embryonic/fetal muscle."
2146a2996,2997
> "P58269-1","RefSeq","NP_478119.1","30824325","Lnc-Dpf3 directly bound to HIF-1alpha."
> "P58269-1","RefSeq","NP_478119.1","18765789","DPF3 adds a further layer of complexity to the BAF complex by representing a tissue-specific anchor between histone acetylations as well as methylations and chromatin remodeling."
2147a2999
> "Q64521-1","RefSeq","NP_034404.3","21908222","Hepatic metabolite perturbations in citrin-mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mice, a model of human citrin deficiency"
2152,2153d3003
< "Q8K2Q9-1","RefSeq","NP_001107784.1","26849555","These results point to a role of CDKL5 in the early steps of neuronal differentiation that can be explained, at least in part, by its association with shootin1. Publication Status: Online-Only"
< "Q8K2Q9-1","RefSeq","NP_001107784.1","23864681","Our data demonstrate the importance of the Shootin1/KIF20B interaction to the dynamic process of pyramidal neuronal polarization and migration."
2159c3009,3013
< "Q6P1H6-1","RefSeq","NP_001240743.1","25343476","Restoring the expression of one Zfp335 target, Ankle2, partially rescues T cell maturation. Publication Status: Online-Only"
---
> "Q61527-1","RefSeq","NP_034284.1","30498032","Loss of Erbb4 expression is associated with impaired behavior and abnormal neural development."
> "Q61527-1","RefSeq","NP_034284.1","30179154","The critical role of ErbB4 signaling in regulating locus coeruleus-noradrenergic neuronal function, is reported. Erratum:[Elife. 2019 Jan 08;8:. PMID: 30618378] Publication Status: Online-Only"
> "Q8BK06-1","RefSeq","NP_076094.2","27197753","FBXO9 directly interacted with PPAR gamma through the activation function-1 domain and ligand-binding domain. FBXO9 decreased the protein stability of PPAR gamma through induction of ubiquitination. Publication Status: Online-Only"
> "Q8BK06-1","RefSeq","NP_076094.2","20459822","ICK and FBX9 are divergently transcribed from a bidirectional promoter that is GC-rich and contains a CpG island. Publication Status: Online-Only"
> "Q99MD6-1","RefSeq","NP_694802.2","20018845","Study shows that CUG codon is used as an inefficient start codon to generate protein Thioredoxin/glutathione reductase isoforms in mouse."
2169a3024,3031
> "Q9QYY1-1","RefSeq","NP_062324.2","29891552","These data reveal that IL-1Ra and IL-36Ra have opposing effects on the outcome of Pseudomonas aeruginosa keratitis"
> "Q9QYY1-1","RefSeq","NP_062324.2","24829417","IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin"
> "Q02780-1","RefSeq","NP_035035.1","30290178","It identified NFIA and ATF3 as drivers of astrocyte differentiation from neural precursor cells while RUNX2 promotes astrocyte maturation."
> "Q61142-1","RefSeq","NP_666155.1","23894536","Spin1 regulates maternal transcripts post-transcriptionally and is involved in meiotic resumption Publication Status: Online-Only"
> "Q61142-1","RefSeq","NP_666155.1","21960006","Spindlin1 localizes to the active ribosomal DNA (rDNA) repeats, and Spindlin1 facilitates the expression of ribosomal RNA genes. Publication Status: Online-Only"
> "Q61142-1","RefSeq","NP_666155.1","18645677","Spin1 isoform2 is a protein expressed highly in adult testis, which might be involved in spermatogenesis and could be necessary for normal sperm motility"
> "Q61142-1","RefSeq","NP_666155.1","18201843","SPINDLIN1 is an important gene for mammalian mitotic chromosome functions, and disrupted regulation results in abnormal cell division, a mechanism that may be involved in tumorigenesis"
> "Q61142-1","RefSeq","NP_666155.1","16098913","Spindlin1 gene may contribute to tumorigenesis"
2170a3033,3037
> "Q9ERQ8-1","RefSeq","NP_444300.1","23881097","Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures."
> "Q9ERQ8-1","RefSeq","NP_444300.1","20820888","Car2, Car3, Car7, and Car15 mRNAs were barely within the detection limits in the mouse harderian gland."
> "Q11204-1","RefSeq","NP_033205.2","27683310","T3gal2-null mice display a reduced respiratory exchange ratio compared to WT mice, indicating a preference for lipid oxidation as an energy source. Despite their altered metabolism, St3gal2-null mice were hyperactive. We conclude that altered ganglioside expression in adipose tissue results in diminished IR sensitivity and late-onset obesity."
> "Q11204-1","RefSeq","NP_033205.2","25846372","St3gal2/3 double-null mice displayed dysmyelination marked by a reduction in major myelin proteins, fewer myelinated axons, a decrease in myelin thickness, possibly by dysregulation of ganglioside-mediated oligodendroglial precursor cell proliferation."
> "Q11204-1","RefSeq","NP_033205.2","21986317","An adult onset cardiac dilatation in a transgenic mouse line with Galbeta1,3GalNAc alpha2,3-sialyltransferase II (ST3Gal-II) transgenes, is reported."
2172a3040
> "Q8BX35-1","RefSeq","NP_780749.3","14749376","EDA-A2 transgenic mice exhibited multifocal myodegeneration; this phenotype was not observed in the absence of XEDAR"
2173a3042,3044
> "P07091-1","RefSeq","NP_035441.1","30080858","FSP1-expressiing fibroblasts maintain preadipocyte pool via PDGF signaling and regulate adipose homeostasis. Publication Status: Online-Only"
> "P07091-1","RefSeq","NP_035441.1","30045697","Studied the role of S100A4 on the proliferation of MB49 bladder cancer stem cells (MSCSs) and MB49 cells. Found S100A4 was significantly up-regulated in MCSCs and led to increased cell proliferation and an increase in NF-kappaB, IKK, IL-2 and TNF; whereas knock-down of S100A4 reversed such effect. Publication Status: Online-Only"
> "P07091-1","RefSeq","NP_035441.1","30196299","S100A4 knockout alone inhibits ATC cells (rich endogenous S100A4) survival and invasion, regardless of the BRAFV600E status, and potentiates the effect of vemurafenib on tumor regression in vitro and in vivo."
2174a3046,3050
> "Q62431-1","RefSeq","NP_031906.1","29462197","Our data show that signals provided by thymic epithelial cells control thymic B cell development by up-regulating Let-7, suppressing Arid3a expression in intrathymic progenitor B cells to limit their proliferation during the neonatal to adult transition. Publication Status: Online-Only"
> "Q62431-1","RefSeq","NP_031906.1","27965054","ARID3A is required for normal murine trophoblast development in vivo.  The results reveal an essential, conserved function for ARID3A in mammalian placental development through regulation of both intrinsic and extrinsic developmental programs."
> "Q62431-1","RefSeq","NP_031906.1","15743806","The ability of Bright to enhance immunoglobulin transcription critically requires functional Bruton's tyrosine kinase ."
> "Q62431-1","RefSeq","NP_031906.1","15456761","Identify regions within Bright that are required for the DNA binding activity of Bright and for its function as a transcription factor"
> "Q62431-1","RefSeq","NP_031906.1","12193717","Variations in Bright binding and matrix attachment region activity contribute to localized control of accessibility and therefore nonrandom gene use during V(D)J recombination."
2181,2184d3056
< "Q8BFW7-1","RefSeq","NP_001139424.1","29251630","Cancer-associated fibroblasts regulate endothelial LPP via a calcium-dependent signaling pathway involving microfibrillar-associated protein 5 (MFAP5), focal adhesion kinase (FAK), ERK, and LPP"
< "Q8BFW7-1","RefSeq","NP_001139424.1","23447672","Interaction between LPP and alpha-actinin, an actin cross-linking protein, is necessary for TGFbeta-induced migration and invasion of ErbB2-expressing breast cancer cells."
< "Q8BFW7-1","RefSeq","NP_001139424.1","22886954","Inactivation of Rho kinase (ROK) with ROK inhibitors significantly inhibited LPP mRNA expression in TGF-beta1-treated SMPCs."
< "Q8BFW7-1","RefSeq","NP_001139424.1","12441356","LPP contains specific domains that enable its focal adhesion and nuclear targeting capacity [LIM-containing lipoma-preferred partner [LPP]"
2199a3072
> "Q9D8Z1-1","RefSeq","NP_081213.1","26924529","Homozygous and compound-heterozygous nonsense and frameshift TRIP4 and ASCC1 mutations that cosegregated with the Prenatal Spinal Muscular Atrophy and Congenital Bone Fracture phenotype"
2215d3087
< "Q6NSU3-1","RefSeq","NP_001159402.1","29483533","GLT8D1 and CSNK2B knockdown promote the proliferation and inhibit the differentiation abilities of neural stem cells, and alter morphology and synaptic transmission of mouse neurons. Erratum:[Nat Commun. 2018 Nov 16;9(1):4905. PMID: 30446647] Publication Status: Online-Only"
2218a3091,3095
> "Q5SXJ3-1","RefSeq","NP_840094.1","26490168","FANCJ play roles in spermatogenesis at two stages: firstly in the proliferative activity that gives rise to the full complement of testicular spermatogonia and secondly in the establishment of appropriate crossovers numbers during prophase I."
> "Q5SXJ3-1","RefSeq","NP_840094.1","20122882","Review of the functions and disease associations of human FANCJ. Review article"
> "Q5SXJ3-1","RefSeq","NP_840094.1","11595410","Compares the human homolog to other members of the RecQ helicase family"
> "Q9JJJ7-1","RefSeq","NP_665915.1","29066530","Porcn mosaicism results in reduced fertility."
> "Q9JJJ7-1","RefSeq","NP_665915.1","29036275","This study showed that postnatal ablation of Porcupine in the uterine luminal epithelium alone results in the decrease in endometrial gland number; mutant females are completely infertile."
2227a3105,3108
> "P16563-1","RefSeq","NP_033446.1","26786179","Crisp2 genetic defects in sperm from humans and mice result in male infertility."
> "P16563-1","RefSeq","NP_033446.1","19686095","Expression and localization of SHTAP in testis and sperm raise the possibility that the SHTAP-CRISP2 complex has a potential role in sperm formation and/or function. Publication Status: Online-Only"
> "P16563-1","RefSeq","NP_033446.1","17377140","These data raise the possibility that CRISP2 is a MAP3K11-modifying protein or, alternatively, that MAP3K11 acts to phosphorylate CRISP2 during acrosome development."
> "P16563-1","RefSeq","NP_033446.1","17202389","Evidence for a functional role of CRISP2 in fertilization."
2242,2245c3123
< "O70494-1","RefSeq","NP_001018052.1","28359915","Sp3 binds and activates the FGFR4 promoter."
< "O70494-1","RefSeq","NP_001018052.1","28522827","Sp3 interacts with the STING promoter and activates the basal transcription of the STING gene. Publication Status: Online-Only"
< "O70494-1","RefSeq","NP_001018052.1","27143785","Dp71 expression in hepatic cells is carried out, in part, by YY1-, Sp1- and Sp3-mediated transcription from the Dp71 promoter."
< "O70494-1","RefSeq","NP_001018052.1","11472836","Sp3 is an essential transcription factor for late bone development."
---
> "Q91WE2-1","RefSeq","NP_082497.2","26497270","Nip30 is expressed in skeletal muscle.Nip30 and Rspry1 common promoter region contains a conserved E-box element. Nip30 localizes to the nucleus."
2251a3130,3137
> "Q9DAS9-1","RefSeq","NP_079554.1","19568691","Modulating Gng12 mRNA levels using RNAi revealed a novel role for the factor in the negative regulation of the overall inflammatory response as based on effects on nitrite and TNFalpha levels. Erratum:[Inflamm Res. 2009 Oct;58(10):725]"
> "Q3UHF7-1","RefSeq","NP_034567.2","30285890","The Shn2 deficiency attenuates bidirectional short-term synaptic plasticity at the medial perforant path-granule cell synapse. Publication Status: Online-Only"
> "Q3UHF7-1","RefSeq","NP_034567.2","29233179","Shn2 knockout mice serve as a unique tool for investigating morphological abnormalities of subcellular-scale structures in schizophrenia, intellectual disability, and its related disorders. Publication Status: Online-Only"
> "Q3UHF7-1","RefSeq","NP_034567.2","16836985","Shn-2 plays a critical role in locomotion and anxiety-like behavior. Stress-induced corticosterone levels were significantly higher in Shn-2(-/-) mice compared to wild-type controls."
> "Q3UHF7-1","RefSeq","NP_034567.2","15699073","Data suggest that Schnurri-2 plays a crucial role in the control of T helper type 2 cell differentiation by regulating NF-kappaB function."
> "Q8C7Q4-1","RefSeq","NP_033058.2","30327195","Our studies demonstrated that RBM4a-regulated alternative splicing constituted another regulatory mechanism for strengthening the influence of PRDM16 on the development of brown adipocytes."
> "Q8C7Q4-1","RefSeq","NP_033058.2","30200638","Study identified a novel splicing network composed of RBM4a, SRSF3, and MAP4K4 in brown adipogenesis and subsequently manipulating the effect of downstream JNK signaling which contributes to insulin resistance and reduced metabolism. Publication Status: Online-Only"
> "Q8C7Q4-1","RefSeq","NP_033058.2","29581187","RBM4 plays a role in neuronal migration via modulating the expression of Dab1 splice isoforms. This finding implies that RBM4 is necessary during brain development and that its deficiency may lead to developmental brain abnormality. Publication Status: Online-Only"
2262a3149,3153
> "P47757-1","RefSeq","NP_033928.1","20969875","Capping protein interacts with both actin protomers at the barbed end of the filament, and the amphipathic helix at the C-terminus of the beta-subunit binds to the hydrophobic cleft on actin."
> "P47757-1","RefSeq","NP_033928.1","19806181","Capzb2 plays an important role in growth cone formation and neurite outgrowth and that the underlying mechanism may involve direct interaction between Capzb2 and microtubules."
> "O35409-1","RefSeq","NP_058050.3","30458729","Decrease in both glutamate and N-acetylaspartate levels in the ipsilateral hippocampus at 24 h post-traumatic brain injury (TBI); however, the reduction in glutamate and N-acetylaspartate levels was less marked in GCP II-KO mice than in WT mice. T2 MR data and brain water-content analysis demonstrated that the extent of cortical edema and brain swelling was less in KO than in WT mice after TBI . Publication Status: Online-Only"
> "O35409-1","RefSeq","NP_058050.3","27091009","Data support the hypothesis that the neuroprotective efficacy of glutamate carboxypeptidase II knockout in traumatic brain injury is mediated via a reduction in oxidative stress. Publication Status: Online-Only"
> "O35409-1","RefSeq","NP_058050.3","25872793","Knockout of the GCPII gene is not embryonic lethal and affords histopathological protection with improved long-term behavioral outcomes after traumatic brain injury"
2266,2275c3157,3160
< "Q69ZU8-1","RefSeq","NP_001012453.1","25218921","Results indicated that mAnkrd6 is a functional homolog of the Drosophila diego gene for mammalian planar cell polarity (PCP) regulation."
< "Q69ZU8-1","RefSeq","NP_001012453.1","20827749","Results indicate that Diversin plays an important role in the proliferation of neuroblasts in the subventricular zone of the adult brain."
< "Q69ZU8-1","RefSeq","NP_001012453.1","19789178","These observations suggest that the centrosomal localization of Diversin is crucial for its function in Wnt signaling."
< "Q69ZU8-1","RefSeq","NP_001012453.1","12203740","These data suggest that ankyrin repeat domain 6 (Ankrd6) may be involved in brain development in interaction not only with Celsr/Flamingo but also with other signaling pathways."
< "Q9ESL4-1","RefSeq","NP_075544.1","27598200","Zak-/- mice demonstrate a distinct ribotoxic stress-associated phenotype in response to ricin. Publication Status: Online-Only"
< "Q9ESL4-1","RefSeq","NP_075544.1","26755636","ZAK is a key player in mammalian limb patterning in humans and mice."
< "Q9ESL4-1","RefSeq","NP_075544.1","24789282","Exome sequencing analysis between SM/J and A/J mice identified 4 genes (Itga6, Zak, Gpr155, and Mtx2) with nonsynonymous coding SNPs. These four genes might be candidate genes for type 2 diabetes caused by gene-gene interactions. Publication Status: Online-Only"
< "Q9ESL4-1","RefSeq","NP_075544.1","15737997","Mixed lineage kinase 7 (MLK7), a splice variant of the human ZAK gene (ortholog of mouse B230120H23Rik), encodes an isoform which is the MAPKKK required for modulation of the stress-activated MAPKs downstream of anisomycin and UV stimulation."
< "Q9ESL4-1","RefSeq","NP_075544.1","15684425","Results show that mixed lineage kinase-like mitogen-activated protein triple kinase (MLTK_-alpha plays a key role in the UVB- and EGF-induced phosphorylation of histone H3 at Ser28."
< "Q9ESL4-1","RefSeq","NP_075544.1","12761180","PKNalpha functions as not only an upstream activator of MLTKalpha but also a putative scaffold protein for the p38gamma MAPK signaling pathway"
---
> "P97477-1","RefSeq","NP_035627.1","30415701","In the absence of AURKC, AURKA localizes to chromosomes in a CPC-dependent manner. These data suggest that AURKC prevents AURKA from localizing to chromosomes by competing for CPC binding. This competition is important for adequate spindle length to support meiosis I. There is also a unique requirement for AURKB to negatively regulate AURKC to prevent aneuploidy."
> "P97477-1","RefSeq","NP_035627.1","29842884","AURKA is expressed in several cell types in the testis. Spermatogonia and spermatocytes express AURKA as expected based on the known role of this kinase in cell division. Surprisingly, we also found AURKA localized to spermatids and the flagellum of spermatozoa."
> "Q9JKK0-1","RefSeq","NP_075356.1","25783055","Found that RCAN1/3 interact with RAF kinases and CN in a non-exclusive manner. Our data suggests that the balance of RCAN interactions with CN and/or RAF kinases may influence T cell positive selection"
> "Q9JKK0-1","RefSeq","NP_075356.1","17767500","The adult mice, RCAN3 was mainly expressed in the neuropil throughout the brain."
2280a3166,3173
> "Q3UZP0-1","RefSeq","NP_001033691.1","30100545","This study has shown that the Endolymphatic Sac in Tric-/- mice showed no changes in morphology or disruption in macromolecular barrier function. The effects of solute leakages in the ES of Tric-/- mice may be very limited and compensable, or that the ES epithelia may have other sealing system covering the lack of tricellulin."
> "Q3UZP0-1","RefSeq","NP_001033691.1","28767685","Findings suggest that both tricellular tight junctions proteins TRIC and LSR have crucial roles for the differentiated cochlear cell survival. Publication Status: Online-Only"
> "Q3UZP0-1","RefSeq","NP_001033691.1","25919114","Tricellulin is a specific redox sensor and sealing element at 3-cell contacts and may compensate as a redox mediator for occludin loss at 2-cell contacts in vivo and in vitro."
> "Q3UZP0-1","RefSeq","NP_001033691.1","21097846","The tricellulin may be a component to maintain the integrity for PNS myelin function and morphology."
> "Q3UZP0-1","RefSeq","NP_001033691.1","20164257","MarvelD3, occludin, and tricellulin define the tight junction-associated MARVEL protein family"
> "Q3UZP0-1","RefSeq","NP_001033691.1","18768749","Knockdown of occludin caused mislocalization of tricellulin to bTJs, implying that occludin supports tricellular localization of tricellulin by excluding tricellulin from bicellular tight junctions."
> "Q3UZP0-1","RefSeq","NP_001033691.1","17186462","In the inner ear, tricellulin is concentrated at the tricellular tight-junctions in cochlear and vestibular epithelia, including the structurally complex and extensive junctions between supporting and hair cells."
> "Q3UZP0-1","RefSeq","NP_001033691.1","16365161","In this study, we identify tricellulin, the first integral membrane protein that is concentrated at the vertically oriented TJ strands of tricellular contacts."
2283,2287d3175
< "Q8K341-1","RefSeq","NP_001136216.1","30953095","ATAT1 found in regulating mouse forebrain development and governing tubulin hyperacetylation during stress responses, but also suggests the existence of an additional alpha-tubulin acetyltransferase."
< "Q8K341-1","RefSeq","NP_001136216.1","29703898","TAK1 directly interacts with and phosphorylates alphaTAT1 at Ser237 to critically enhance its catalytic activity. Publication Status: Online-Only"
< "Q8K341-1","RefSeq","NP_001136216.1","28687926","Atat1 knockdown resulted in a significant increase in the expression of ACTH-producing genes and decreased the dexamethasone-induced nuclear translocation of glucocorticoid receptor accompanied with a reduction in alpha-tubulin acetylation."
< "Q8K341-1","RefSeq","NP_001136216.1","27976998","Here the authors demonstrate that mice lacking the alpha-tubulin acetyltransferase Atat1 in sensory neurons display profound deficits in their ability to detect mechanical stimuli. Publication Status: Online-Only"
< "Q8K341-1","RefSeq","NP_001136216.1","23126280","Acetylation of alpha-tubulin is under the control of the acetyltransferase MEC-17 and deacetylases SIRT2 (Sirtuin 2) and HDAC6 (histone deacetylase 6). Adipocyte development is inhibited in MEC-17-knockdown cells, but enhanced in MEC-17-overexpressing cells."
2292a3181,3183
> "O55188-1","RefSeq","NP_058059.2","29775615","This study provides a new understanding of DMP1's function in regulation of osteogenesis: not only an enhancer of bone formation, but also a negative regulator of mesenchymal stem cell differentiation in bone."
> "O55188-1","RefSeq","NP_058059.2","28822114","Study not only revealed a novel element, i.e., DMP1-PG, that regulated BBB formation, but also assigned a new function to DMP1-PG. Erratum:[Protein Cell. 2018 Aug 29;:. PMID: 30159643]"
> "Q8CDJ8-1","RefSeq","NP_084134.2","26437238","Data establish Stonin1 as a specific adaptor for the endocytosis of NG2 and as an important factor for focal adhesion dynamics and cell migration. Publication Status: Online-Only"
2296a3188,3190
> "Q9ESM6-1","RefSeq","NP_076097.1","28849762","The results establish GDE3 as a negative regulator of the uPAR signaling network and, furthermore, highlight GPI-anchor hydrolysis as a cell-intrinsic mechanism to alter cell behavior. Publication Status: Online-Only"
> "Q9ESM6-1","RefSeq","NP_076097.1","19596859","GDE3 substrate GroPIns is a candidate mediator for osteoblast proliferation"
> "Q9ESM6-1","RefSeq","NP_076097.1","12933806","GDE3 is a novel seven-transmembrane protein with a GP-PDE-like extracellular motif expressed during osteoblast differentiation that accelerates the program of osteoblast differentiation and is involved in morphological change of cells"
2308d3201
< "A2AJL3-1","RefSeq","NP_001106883.1","29220483","The strength of Fggy mRNA expression significantly correlated with increased whole body weight and gonadal fat weight of males but not females."
2312a3206
> "Q80UG8-1","RefSeq","NP_001014974.1","29593216","Klf4 polyglutamylation plays a critical role in the regulation of cell reprogramming and pluripotency maintenance in a process that involves TTLL4 and TTLL1 Publication Status: Online-Only"
2313a3208,3213
> "Q8R4I7-1","RefSeq","NP_659195.3","28854365","KAR-mediated excitation of interneurons is contingent upon Neto1 because kainate yields comparable effects in Neto2 knockouts and wild-types but fails to excite interneurons or recruit inhibition in Neto1 knockouts."
> "Q8R4I7-1","RefSeq","NP_659195.3","28680963","The data of this study showed that a novel role for NETO1 in regulation of axonal Kainate Receptors and identify its physiological significance in development of the CA3-CA1 circuit. Publication Status: Online-Only"
> "Q8R4I7-1","RefSeq","NP_659195.3","21593317","Assembly with NETO1 and NETO2 differentially modifies homomeric glutamate K1 (GluK1) kainate receptor gating."
> "Q8R4I7-1","RefSeq","NP_659195.3","19243221","Neto1 regulates NMDA receptor-dependent synaptic plasticity and cognition."
> "Q8R4I7-1","RefSeq","NP_659195.3","12810072","Data describe the isolation and characterization of a novel gene, Btcl1 (brain-specific transmembrane protein containing two CUB and an LDLa domains), which has significant homology with neuropilin-1 and -2 in their CUB domains. [Btcl1]"
> "Q8R4I7-1","RefSeq","NP_659195.3","11943477","Focuses mainly on human NETO1 but also describes identification of mouse Neto1."
2319a3220,3223
> "O09048-1","RefSeq","NP_034802.1","15601842","K6alpha, K6beta, and K17 have roles in normal development of the nail bed epithelium"
> "O09048-1","RefSeq","NP_034802.1","15385554","Krtap16 is a hair keratin-associated protein gene complex regulated by Hoxc13; localized to chromosome 16"
> "Q91YI4-1","RefSeq","NP_663404.1","31270323","Mice lacking beta-arrestin-2 (barr2) selectively in adipocytes show significantly reduced adiposity and striking metabolic improvements when consuming excess calories. Publication Status: Online-Only"
> "Q91YI4-1","RefSeq","NP_663404.1","30576947","Findings show that chemerin-activated CMKLR1 regulation in inflammatory macrophages is largely GRK6 and beta-arrestin mediated, which may impact innate immunity and have therapeutic implications in rheumatic disease."
2327a3232
> "Q8CCT4-1","RefSeq","NP_808587.1","27580811","Sufficient to increase the growth rate of pituitary progenitors, suggesting a role as a proto-oncogene"
2337,2338c3242,3243
< "P97434-1","RefSeq","NP_036157.2","16243315","P116Rip oligomerizes via its C-terminal coiled-coil domain and, when overexpressed, inhibits RhoA-induced SRF activation without affecting RhoA-GTP levels."
< "P97434-1","RefSeq","NP_036157.2","12732640","P116Rip is an F-actin-binding protein with in vitro bundling activity and in vivo capability of disassembling the actomyosin-based cytoskeleton."
---
> "Q9CYB0-1","RefSeq","NP_075722.1","28087809","These data identify Trim13 as a positive regulator of NF-kappaB activation and suggest that lysine 29-linked polyubiquitination is a specific ubiquitin-linked pattern involved in the control of TLR2 signaling."
> "Q9CYB0-1","RefSeq","NP_075722.1","25008915","TRIM13 interacts with MDA5 and negatively regulates MDA5-mediated type I IFN production."
2341,2346d3245
< "Q8VBT9-1","RefSeq","NP_081153.1","25944897","Insulin acts through TUG proteins to control IRAP targeting, similar to GLUT4; the activity of vasopressin, an IRAP substrate, is reduced in mice with disrupted TUG action in muscle."
< "Q8VBT9-1","RefSeq","NP_081153.1","25453902","A conditional expression in mice of the fusion gene ASPSCR1-TFE3 from human alveolar soft part sarcoma (ASPS) generated a model that recapitulates the human tumor histologically and by expression profile."
< "Q8VBT9-1","RefSeq","NP_081153.1","23744065","Data indicate that insulin stimulates proteolysis of TUG (tether containing a ubiquitin regulatory X (UBX) domain for glucose transporter 4 (GLUT4)) to translocate GLUT4 in muscle."
< "Q8VBT9-1","RefSeq","NP_081153.1","22610098","Data suggest a model whereby insulin stimulates TUG cleavage to liberate GLUT4 storage vesicles from the Golgi matrix, which promotes GLUT4 translocation to the cell surface and enhances glucose uptake."
< "Q8VBT9-1","RefSeq","NP_081153.1","17202135","Insulin-stimulated dissociation of TUG and GLUT4 as an important action by which insulin stimulates glucose uptake."
< "Q8VBT9-1","RefSeq","NP_081153.1","14562105","TUG traps endocytosed GLUT4 and tethers it intracellularly, and insulin mobilizes this pool of retained GLUT4 by releasing this tether"
2349,2350c3248,3256
< "O54918-1","RefSeq","NP_997563.1","30590105","Bim is expressed in dopaminergic neurons and contributes to parkinsonian neurodegeneration. The transcriptional activation of Bim by c-Jun promotes MPTP-induced nigral dopaminergic neuron death. This study is significant because it precisely demonstrates a pro-death role of c-Jun/Bim upregulation in nigral dopaminergic neurons by using cell type-specific knockout mice."
< "O54918-1","RefSeq","NP_997563.1","30610162","Fas and Bim both function to regulate T cell apoptosis in early stages of viral infections and during costimulation blockade."
---
> "P40223-1","RefSeq","NP_031808.2","29868014","Expression of the Sle2c2 Csf3r allele confers autoimmune suppression through the expansion of tolerogenic dendritic cells Publication Status: Online-Only"
> "P40223-1","RefSeq","NP_031808.2","28320832","This study shows that dorsal root ganglion neurons cultured in G-CSF failed to respond to G-CSF in vitro, and Csf3r gene expression could not be detected in dorsal root ganglion neurons by single-cell RT-PCR"
> "Q8BX10-1","RefSeq","NP_082549.2","29770487","Melatonin treatment inhibited the Ripk3-PGAM5-CypD-mPTP cascade and thus reduced cellular necroptosis, conferring a protective advantage to the endothelial system in IR stress."
> "Q8BX10-1","RefSeq","NP_082549.2","29524517","Findings suggest that HO-1 protects against I/R-induced hepatic injury via regulation of mitochondrial QC by PGAM5 signaling."
> "Q8BX10-1","RefSeq","NP_082549.2","29438981","Damaged mitochondria may induce replenishment of the mitochondrial pool by cell-intrinsic activation of Wnt signaling via the Pgam5-beta-catenin axis."
> "Q8BX10-1","RefSeq","NP_082549.2","26381214","Results identify a crucial role for RIPK3-PGAM5-Drp1/NFAT signalling in NKT cell activation, and further suggest that RIPK3-PGAM5 signalling may mediate crosstalk between mitochondrial function and immune signalling. Publication Status: Online-Only"
> "Q8BX10-1","RefSeq","NP_082549.2","25222142","Loss of PGAM5 disables PINK1-mediated mitophagy in vitro and leads to dopaminergic neurodegeneration and mild dopamine loss in vivo causing a Parkinson's-like movement disorder. Publication Status: Online-Only"
> "Q8BX10-1","RefSeq","NP_082549.2","25012655","Data indicate that phosphoglycerate mutase 5 (PGAM5) contains an N-terminal WDXNWD motif required for multimerization and maximal phosphatase activity."
> "Q8BX10-1","RefSeq","NP_082549.2","22265414","Experimental data indicate that the two splice variants of the mitochondrial protein phosphatase PGAM5 are at the convergent point of multiple necrosis pathways."
2357a3264,3265
> "P28654-1","RefSeq","NP_031859.1","30099770","Taken together, these findings suggest that DECORIN promotes the proliferation and migration of ORS keratinocytes in vitro and maintains hair anagen in mice."
> "O55040-1","RefSeq","NP_034471.1","28864416","These results suggested that NMU can act directly on beta cells through NMUR1 in an autocrine or paracrine fashion to suppress insulin secretion. Collectively, our results highlight the crucial role of NMU in suppressing pancreatic insulin secretion, and may improve our understanding of glucose homeostasis."
2358a3267,3270
> "E9Q784-1","RefSeq","NP_080359.2","29547716","Zc3h13 plays a critical role in anchoring WTAP, Virilizer, and Hakai in the nucleus to facilitate m(6)A methylation and to regulate murine embryonic stem cell self-renewal."
> "E9Q784-1","RefSeq","NP_080359.2","29535189","Identified Zc3h13 (zinc finger CCCH domain-containing protein 13)/Flacc [Fl(2)d-associated complex component] as a novel interactor of m(6)A methyltransferase complex components in Drosophila and mice"
> "Q5DTM8-1","RefSeq","NP_892044.1","28453857","The results demonstrate that Fbxl19 recruitment to CpG islands is required for Rnf20-mediated H2B monoubiquitination."
> "Q5DTM8-1","RefSeq","NP_892044.1","20738173","The observed defects in the radiation response of Bre1a/b-deficient cells"
2368,2369d3279
< "Q64338-3","RefSeq","NP_001153425.1","30469494","Cardiac Pde1C is a direct transcriptional target of PPARalpha. Publication Status: Online-Only"
< "Q64338-3","RefSeq","NP_001153425.1","29860631","By whole-mount immunofluorescence on postnatal day 3 mouse cochlea, we show its expression in outer (OHC) and inner (IHC) hair cells cytosol co-localizing with Lamp-1 in lysosomes. Furthermore, we provide evidence that the variant alters the PDE1C hydrolytic activity for both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)."
2387a3298
> "Q60644-1","RefSeq","NP_033499.1","30018108","Type I interferon increases liver X receptor (LXR) expression following gammaherpesvirus infection. Gammaherpesvirus replication is increased in macrophages derived from mice genetically deficient in both LXRalpha and LXRbeta isoforms. Suppression of cholesterol and fatty acid synthesis pathways by liver X receptors in primary macrophages creates an intrinsic antiviral state that attenuates gammaherpesvirus replication. Publication Status: Online-Only"
2404a3316,3321
> "P41593-1","RefSeq","NP_035329.2","30682096","Data demonstrate that PPR expression along the osteoblast lineage is essential for exercise to improve the mechanical properties of cortical bone. Furthermore, the influence of PPR activation on material properties is unique to exercise and not during normal growth and development. Publication Status: Online-Only"
> "P41593-1","RefSeq","NP_035329.2","30053608","Acute calcemic response to PTH in vivo in mice lacking PTH receptors in osteocytes vs littermate controls, is resported."
> "Q60596-1","RefSeq","NP_033558.3","29477978","Interaction with phosphorylated XRCC1 is a requirement for significant APTX recruitment to cellular DNA damage and enzymatic activity in cell extracts."
> "Q60596-1","RefSeq","NP_033558.3","29100039","Repair independent of the well documented XRCC1-PNKP interaction was studied. XRCC1 can mediate repair of strand breaks without PNKP binding."
> "Q60596-1","RefSeq","NP_033558.3","28436431","Unrepaired single strand DNA breaks (SSBs) activate DNA damage response and increase the expression of inflammatory cytokines through NF-kappaB signalling. Pressure overload-induced heart failure is more severe in the mice lacking XRCC1, an essential protein for SSB repair. Publication Status: Online-Only"
> "O70435-1","RefSeq","NP_035314.3","26070558","Protein interaction between Ambn and Psma3 can facilitate redistribution of ameloblastin domains within forming enamel."
2409a3327,3329
> "Q8C796-1","RefSeq","NP_473389.2","28049845","An INSM1/RCOR1/2 complex controls the balance of proliferation and differentiation during brain development."
> "Q8C796-1","RefSeq","NP_473389.2","26795843","Rcor2, a co-repressor of LSD1, controls neurogenesis in the developing mouse brain. Publication Status: Online-Only"
> "Q8C796-1","RefSeq","NP_473389.2","25793264","CoREST1 promotes tumorigenesis in a breast cancer model at least in part through regulation of gene expression patterns in tumor cells. Publication Status: Online-Only"
2415a3336,3341
> "Q9D6X5-1","RefSeq","NP_081448.2","27272163","Our knowledge, this is the first report to indicate that Rfvt3 contributes to placental riboflavin transport, and that disruption of Slc52a3 gene caused neonatal mortality with hyperlipidemia and hypoglycemia owing to riboflavin deficiency. Publication Status: Online-Only"
> "Q9D6X5-1","RefSeq","NP_081448.2","26976849","Loss of Slc52a3 gene is associated with Brown-Vialetto-van Laere syndrome."
> "Q9D6X5-1","RefSeq","NP_081448.2","26660539","The RFVT-3 system is the main transporter involved in carrier-mediated riboflavin uptake in the native mouse small and large intestine"
> "Q923M0-1","RefSeq","NP_203535.1","18202305","R16A at the membrane may mediate the PB signal to initiate CAR nuclear translocation, through a mechanism including its dimerization and inhibition of PP1beta activity."
> "Q8R2V3-1","RefSeq","NP_775540.4","30602440","ZFP445 and ZFP57 act together, maintaining all but one imprinting control region in vivo"
> "Q8R2V3-1","RefSeq","NP_775540.4","23291531","KAP-1 may contribute to the repression of Ey and beta-major globin gene transcription through recruitment to the promoters of these two genes, mediated by the interaction of KAP-1 with either Zfp445 or MafK, respectively"
2417a3344,3348
> "P09813-1","RefSeq","NP_038502.2","29618729","High Apolipoprotein A-II is associated with acute-phase response and AA amyloidosis by conformational changes of plasma lipoprotein structure. Publication Status: Online-Only"
> "P09813-1","RefSeq","NP_038502.2","27756649","Study reports a deterministic role for the B6 apoa2 gene polymorphism in respiratory rhythmogenesis. The in vivo inheritance pattern discloses a recessive effect of the B6 allele on the apnea phenotype, as the presence of both B6 alleles in the brain is required for transcript and trait expression; in contrast, apoa2 mRNA expression in the liver requires only one allele."
> "Q8C0F9-1","RefSeq","NP_848853.2","23451081","The study demonstrates the distinct expression of Prss23 and Prss35 in the periimplantation uterus and the dispensable role of Prss35 in fertility and embryo development."
> "Q8C0F9-1","RefSeq","NP_848853.2","18566130","HtrA1 and PRSS35 may be involved in ovulation and corpus luteum formation and regression, and that PRSS23 may play a role in follicular atresia"
> "Q8C0F9-1","RefSeq","NP_848853.2","16870946","Prss35 mRNA levels increased around the time of ovulation and remained elevated in the developing corpus luteum GeneRIF: Mouse ortholog of human PRSS35 is an ovary-selectively expressed gene."
2423a3355,3356
> "Q8BJ52-1","RefSeq","NP_083701.2","25074937","Data indicate that plasticity-related genes 5 (PRG5) expression is involved in proper spine formation."
> "Q8BJ52-1","RefSeq","NP_083701.2","20032306","Data show that PRG5 induces filopodia growth independently of Cdc42, and that axon collapse and RhoA activation induced by LPA and myelin-associated neurite inhibitor Nogo-A is attenuated in the presence of PRG5."
2431a3365
> "A2A8Z1-1","RefSeq","NP_775485.2","19413330","Includes data showing N-alpha terminal acetylation of the homologous human protein (OSBL9_HUMAN), where the N-terminal sequence is nASIMEGPLSK following cleavage of the initiating Met-1 derived from a downstream start codon in the transcript."
2441a3376
> "P82350-1","RefSeq","NP_033187.1","30448410","The Danger Signal Extracellular ATP Is Involved in the Immunomediated Damage of alpha-Sarcoglycan-Deficient Muscular Dystrophy."
2451a3387,3388
> "Q5SW46-1","RefSeq","NP_536345.2","24204315","We postulate that Lpo upregulation in the intestinal epithelium of miR-10a deficient mice together with the predominant abundance of estrogens in female animals mainly accounts for the sex-related cancer phenotype we observed"
> "Q5SW46-1","RefSeq","NP_536345.2","22343415","Methylation of the Lpo intragenic CpG island was not directly induced by inflammation, because dextran sulfate sodium-induced colitis did not increase DNA methylation in B6 DKO colon. Also, Lpo DNA methylation is not correlated with gene expression"
2457a3395,3397
> "A2A884-1","RefSeq","NP_034787.2","24563464","Thus, Alg2, as a downstream mediator of Hivep3, suppresses osteogenesis, whereas it promotes chondrogenesis."
> "A2A884-1","RefSeq","NP_034787.2","23945236","Knockdown of Shn3 in adult mice results in a high-bone mass phenotype."
> "A2A884-1","RefSeq","NP_034787.2","11804591","KRC overexpression inhibits while antisense or dominant-negative KRC enhances NFkappaB-dependent transactivation and JNK phosphorylation and consequently, apoptosis and cytokine gene expression"
2461a3402,3404
> "P70196-1","RefSeq","NP_033450.2","30392071","MiR-590-3p has the ability to suppress LPS-induced Acute Kidney Injury and podocyte apoptosis by targeting TRAF6"
> "P70196-1","RefSeq","NP_033450.2","30190125","The expression of TRAF6 in T cells might be implicated in tissue-specific sialadenitis by regulating the chemokine-chemokine receptor system"
> "P70196-1","RefSeq","NP_033450.2","30103950","The data suggest that TFAF6 inhibition reduces choroidal neovascularization formation via down-regulating expression of HIF-1a and VEGF and activation of macrophages and microglia."
2474a3418,3420
> "P28776-1","RefSeq","NP_032350.1","31325428","Expression of IDO1 in the intestinal epithelial promotes secretory cell differentiation, via Ahr/Notch signaling, and mucus production, to alter muscus-associated bacteria."
> "P28776-1","RefSeq","NP_032350.1","30403776","The current study shows that the Ido1 and Ido2 genes are imprinted and maternally expressed in mouse placentas. DNA methylation analysis demonstrates that nine CpG sites at the Ido1 promoter constitute a differentially methylated region that is highly methylated in sperm but unmethylated in oocytes"
> "P28776-1","RefSeq","NP_032350.1","30693061","High IDO1 expression is associated with Poststroke Depression. Publication Status: Online-Only"
2479a3426
> "Q922Q5-1","RefSeq","NP_598821.1","20011239","PAPST-dependent sulfation of heparan sulfate or chondroitin sulfate chains regulates the extrinsic signaling required for the maintenance and normal differentiation of mouse embryonic stem cells.[PAPST1, PAPST2] Publication Status: Online-Only"
2481a3429
> "Q80XC3-1","RefSeq","NP_852064.2","24239119","These findings identify RN-tre as the Rab5-GAP that spatiotemporally controls focal adhesion remodeling during chemotactic cell migration."
2483a3432,3437
> "Q60651-1","RefSeq","NP_034779.1","27438766","This study shows that after mouse cytomegalovirus infection, Ly49D augmented IFN-gamma production by virus-specific Ly49H(+) NK cells and preferentially promoted the generation of memory Ly49H(+) NK cells"
> "Q60651-1","RefSeq","NP_034779.1","19247984","These data demonstrate that DAP10 does associate with Ly49H and Ly49D in primary NK cells."
> "Q60651-1","RefSeq","NP_034779.1","19109149","Ly49D stimulation triggers cellular activation of CD4 and CD8 populations; Ly49D recognizes the classical hamster class I molecule Hm1-C4 on CHO cells, as demonstrated by the killing of Hm1-C4-transfected thymoma cells by Ly49D cytotoxic T cells."
> "P23927-1","RefSeq","NP_034094.1","30497777","Results reveal a novel function for extracellular CRYAB in the regulation of neuroinflammation; targeting extracellular CRYAB-modulated neuroinflammation is a potential therapeutic intervention for multiple sclerosis"
> "P23927-1","RefSeq","NP_034094.1","30389787","Chaperone alphaB-crystallin (CRYAB) is a MYOC-binding partner and that co-expression of these two proteins increases protein aggregates."
> "P23927-1","RefSeq","NP_034094.1","29338044","Findings offer additional insight into the early transcriptional changes caused by Cryaa and Cryab mutations associated with autosomal dominant cataracts, and indicate that the transcript levels of certain genes are affected by the expression of mutant alpha-crystallin in vivo Publication Status: Online-Only"
2500a3455,3457
> "P60762-1","RefSeq","NP_077751.1","27573846","In round spermatids, MRG15 colocalizes with splicing factors PTBP1 and PTBP2 at H3K36me3 sites between the exons and single intron of transition nuclear protein 2 (Tnp2). Thus, our results reveal that MRG15 is essential for pre-mRNA splicing during spermatogenesis and that epigenetic regulation of pre-mRNA splicing by histone modification could be useful to understand not only spermatogenesis but also, epigenetic disorder"
> "P60762-1","RefSeq","NP_077751.1","24451372","HDAC2-dependent deacetylation of MORF4L1 enhances MORF4L1 homodimerization, thus facilitating the functionality of complex formation to repress cell proliferation. Erratum:[J Biol Chem. 2014 Sep 5;289(36):24943]"
> "E9Q7L6-1","RefSeq","NP_851305.2","12351180","The dynamic and specific expression of Foxn2 during embryonic development suggest multiple independent roles for Foxn2 function during gestation"
2506,2508c3463,3468
< "O55143-1","RefSeq","NP_001103610.1","30717322","For the in vivo study, BALB/c mice were treated with ATO and/or Sal A via daily tail vein injections for two weeks... Sal A increased sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA) activity and expression, alleviated [Ca(2+)]ER depletion, and decreased ER stress-related protein expression Publication Status: Online-Only"
< "O55143-1","RefSeq","NP_001103610.1","30299255","Here the show that DWORF has a higher apparent binding affinity for SERCA than PLN and that DWORF overexpression mitigates the contractile dysfunction associated with PLN overexpression, substantiating its role as a potent activator of SERCA. Publication Status: Online-Only"
< "O55143-1","RefSeq","NP_001103610.1","29986885","These data demonstrate that the activity of RyR2, but not SERCA2a, is a major determinant of Ca2+ alternans in intact working mouse hearts."
---
> "Q9DAM5-1","RefSeq","NP_080347.1","26316591","Chronic alcohol exposure negatively impacts pancreatic mitochondrial thiamin pyrophosphate transport, and this effect is exerted, at least in part, at the level of Slc25a19 transcription and appears to involve an epigenetic mechanism."
> "Q9DAM5-1","RefSeq","NP_080347.1","18280798","We review the evidence that the function of the SLC25A19 gene product, previously identified as the mitochondrial deoxyribonucleotide carrier (DNC), is actually the transport of thiamine pyrophosphate.[review] Review article"
> "Q9DAM5-1","RefSeq","NP_080347.1","17035501","Mitochondria of Slc25a19(-/-) and Amish lethal microcephaly cells have undetectable and markedly reduced thiamine pyrophosphate content, respectively"
> "Q99NH2-1","RefSeq","NP_001013599.1","30467379","Loss of Par3 promotes prostatic tumorigenesis by enhancing cell growth and changing cell division modes"
> "Q99NH2-1","RefSeq","NP_001013599.1","30018153","Loss of endothelial PAR-3 disrupts regional axial cell polarity and increases pro-inflammatory response of endothelial cells."
> "Q99NH2-1","RefSeq","NP_001013599.1","29899142","Radial glial progenitor behavior and cortical development are controlled by temporally distinct actions of partitioning-defective 3 (PARD3) in concert with dynamic HIPPO signaling"
2514a3475
> "Q8BP71-1","RefSeq","NP_780596.1","30867288","RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure"
2516a3478
> "Q9Z2H5-1","RefSeq","NP_038538.1","19503082","Study describes a previously unknown mechanism that governs activity-dependent GluR1 trafficking, reveals an interaction between AMPAR palmitoylation and phosphorylation, and underscores the importance of 4.1N in AMPAR trafficking and synaptic plasticity."
2520a3483,3486
> "Q811P0-1","RefSeq","NP_758462.2","12809675","PAT3 was isolated and identified, but its function is not yet known."
> "Q64374-1","RefSeq","NP_033086.1","30266650","In SMP30 deficient mice, colitis was significantly exacerbated as demonstrated by increased mortality (p=0.001), body weight loss (p=0.0105 at day 8), rectal bleeding (p=0.0047 at day 8) and diarrhea (p=0.0030 at day 8), histological scores (ulcers, p=0.0002; edema, p=0.0125; leukocyte infiltration, p=0.0016) and productions of pro-inflammatory cytokines (IL-1alpha, p=0.0452; IL-6, p=0.0074; G-CSF)."
> "Q64374-1","RefSeq","NP_033086.1","28652426","It was confirmed that hair growth was significantly promoted; hair growth from hair papilla cells was also confirmed by HE staining of the shaved backs of SMP-30/GNL-KO mice in the vitamin C(+) group"
> "Q64374-1","RefSeq","NP_033086.1","12368201","Results demonstrate that SMP30 acts to protect cells from apoptosis"
2527a3494,3497
> "Q80XP9-1","RefSeq","NP_001258608.1","26861815","WNK3 knockout mice show faster neurological functional recovery after occlusion of the left middle cerebral artery."
> "Q80XP9-1","RefSeq","NP_001258608.1","16357011","WNK3 is likely a component of one of the mechanisms that determines the balance between renal NaCl reabsorption and K+ secretion."
> "Q80XP9-1","RefSeq","NP_001258608.1","16275913","Effects of WNK3 on these transporters and their coexpression in renal epithelia implicate WNK3 in NaCl, water, and blood pressure homeostasis, perhaps via signaling downstream of vasopressin"
> "Q80XP9-1","RefSeq","NP_001258608.1","16275911","Suggest that WNK3 is part of the Cl(-)/volume-sensing mechanism necessary for the maintenance of cell volume during osmotic stress and the dynamic modulation of GABA neurotransmission"
2532a3503,3505
> "Q80V72-1","RefSeq","NP_083910.2","30006360","IP6K2 binds selectively to the neuronal protein 4.1N. Both are highly expressed in granule cells of the cerebellum. In IP6K2 knock-out mice, IP6K2-4.1N interactions in granule cells regulate Purkinje cell morphology, the viability of cerebellar neurons, and psychomotor behavior."
> "Q80V72-1","RefSeq","NP_083910.2","25617365","IP6K2 is a major mediator of cancer cell migration and tumor metastasis, acting by enhancing cell-matrix adhesion and decreasing cell-cell adhesion."
> "Q80V72-1","RefSeq","NP_083910.2","19430495","Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma."
2542a3516,3517
> "Q8BYW9-1","RefSeq","NP_780522.1","22310717","The characterization of A130022J15Rik, a mouse gene homolog of Drosophila Eogt (Eogt 1), was reported."
> "Q61137-1","RefSeq","NP_031521.2","11861479","Astrotactin is required for appropriate and timely migration of cerebellar granule cells."
2543a3519,3523
> "Q9D8U8-1","RefSeq","NP_077187.1","28771744","Thyroid cancer model using carcinogen and an anti-thyroidal agent revealed that Snx5(-/-) mice developed metastasizing thyroid tumors with activation of MAP kinase and AKT pathways"
> "Q9D8U8-1","RefSeq","NP_077187.1","28252385","Finally, Chlamydia trachomatis infection interferes with the SNX5:cation-independent mannose-6-phosphate receptor interaction, suggesting that Chlamydia IncE and cation-independent mannose-6-phosphate receptor are dependent on the same binding surface on SNX5. Publication Status: Online-Only"
> "Q9D8U8-1","RefSeq","NP_077187.1","26459636","Findings reveal the important contribution of dorsal ruffing to receptor-activated macropinocytosis in primary macrophages and show that SNX5 selectively regulates macropinosomes derived from the dorsal ruffles."
> "Q9D8U8-1","RefSeq","NP_077187.1","23526992","Histological analysis revealed that Snx5(-/-) mice exhibited thickened alveolar walls associated with undifferentiated alveolar epithelial type I cells. In contrast, type II cells were intact, exhibiting normal surfactant synthesis and secretion."
> "Q9D8U8-1","RefSeq","NP_077187.1","22486813","Data indicate high expression of sorting nexin 5 (Snx5) in chemically induced papillary thyroid carcinoma."
2545,2548c3525,3529
< "Q9QYN3-1","RefSeq","NP_001170844.1","28867182","Together, our results suggest that KLF4 regulates asthma development in a TSLP- and fibrocyte-dependent manner."
< "Q68FG0-1","RefSeq","NP_001003916.1","30177510","RNF220 interacts with, and is co-expressed with, a zinc-finger protein ZC4H2, and they cooperate to degrade Dbx1/2 and Nkx2.2. Co-expression of RNF220 and ZC4H2 further promotes the ability of Nkx6.1 to induce ectopic Chx10+ V2 interneurons. Publication Status: Online-Only"
< "Q68FG0-1","RefSeq","NP_001003916.1","28814648","Results demonstrate that ZC4H2 promotes BMP signaling and is involved in BMP regulated myogenic and osteogenic differentiation of mouse myoblast cells."
< "Q68FG0-1","RefSeq","NP_001003916.1","23623388","In mouse primary hippocampal neurons, transiently produced ZC4H2 localized to the postsynaptic compartment of excitatory synapses, and the altered protein influenced dendritic spine density."
---
> "Q00993-1","RefSeq","NP_033491.2","30541554","Axl and Tyro3, but not Mertk, have an important role in platelet activation and thrombus formation Publication Status: Online-Only"
> "Q00993-1","RefSeq","NP_033491.2","30335822","Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis. Publication Status: Online-Only"
> "Q9QYC0-1","RefSeq","NP_038485.1","29032200","Sez6l2 is one of the auxiliary subunits of the AMPA receptor and acts as a scaffolding protein to link GluR1 to ADD. Furthermore, Sez6l2 overexpression upregulates ADD phosphorylation, whereas siRNA-mediated downregulation of Sez612 prevents ADD phosphorylation, suggesting that Sez6l2 modulates AMPA-ADD signal transduction."
> "Q9QYC0-1","RefSeq","NP_038485.1","28982183","Reduction in ADD1 protein in NEK1 mutant mice is associated with hyperphosphorylation of ADD1, thereby preventing the interaction with MYO10 during meiotic spindle formation Publication Status: Online-Only"
> "Q9QYC0-1","RefSeq","NP_038485.1","27068466","Adducin activity is not essential for actin ring assembly and periodicity but is necessary to control the diameter of both actin rings and axons and actin filament growth within rings."
2549a3531,3533
> "Q80TH2-3","RefSeq","NP_001276404.1","29980571","Tumor organoids derived from Erbin/Apc double knockout mice displayed increased tumor initiation potential and activation of Wnt signaling"
> "Q80TH2-3","RefSeq","NP_001276404.1","26025865","Overexpression of FHL2 alone had no effect on Erbin expression, but in the presence of MITF, Erbin expression was decreased."
> "Q80TH2-3","RefSeq","NP_001276404.1","26056141","By degrading Erbin and Nrf2, Sag activates the Ras-Raf pathway and causes ROS accumulation to trigger autophagy and senescence"
2552a3537,3540
> "Q7TPM3-1","RefSeq","NP_112449.1","25215946","NFATc3 interacted in a SUMO-dependent manner with Trim17, an E3 ubiquitin ligase necessary for neuronal apoptosis"
> "Q7TPM3-1","RefSeq","NP_112449.1","22976837","Trim17 contributes to the ubiquitination and the proteasomal degradation of Mcl-1 in neurons."
> "Q7TPM3-1","RefSeq","NP_112449.1","20559321","Overexpression and silencing data indicate that Trim17 is necessary and sufficient for inducing the Bax-dependent intrinsic pathway of neuronal apoptosis and that its pro-apoptotic effect depends on its E3 activity."
> "Q7TPM3-1","RefSeq","NP_112449.1","19358823","Terf interacts with TRIM44;TRIM44 inhibited ubiquitination of terf, and thus stabilized the protein."
2567a3556,3562
> "Q8CD15-1","RefSeq","NP_080186.3","28967702","Results demonstrate the TGFbeta signaling pathway plays a critical role in regulating Mina expression and SNP rs4191790 controls heritable variation in Mina expression level, raising important questions regarding the evolution of an allele that uncouples Mina expression from the TGFbeta signaling pathway."
> "Q8CD15-1","RefSeq","NP_080186.3","25669985","Results suggest that mdig may contribute to silica-induced lung fibrosis by altering the balance between Th17 and Treg cells."
> "Q8CD15-1","RefSeq","NP_080186.3","25282476","Mina: a Th2 response regulator meets TGFbeta. Review article"
> "Q8CD15-1","RefSeq","NP_080186.3","24324617","Sp1/3 transcription factors trigger Mina expression through additive activity targeted to a cluster of four Sp1/3 binding sites forming the P1 promoter. Publication Status: Online-Only"
> "Q8CD15-1","RefSeq","NP_080186.3","23748603","Mina53 plays a role in the allergic response to inhaled allergens, possibly through controlling IL-4 production."
> "Q8CD15-1","RefSeq","NP_080186.3","19561615","Mina specifically bound to and repressed the Il4 promoter. Mina overexpression in transgenic mice impaired Il4 expression, whereas its knockdown in primary CD4(+) T cells led to Il4 derepression."
> "Q8CD15-1","RefSeq","NP_080186.3","16533354","Mina53 is prominently expressed in proliferating, undifferentiated spermatogonia, and plays a role in cell proliferation from the spermatogonial stage to the meiotic prophase in spermatogenesis, but not in meiotic divisions per se."
2572a3568,3570
> "Q8BWH0-1","RefSeq","NP_766346.1","21511949","The preferred substrate and axonal localization of SLC38A7 close to the synaptic cleft indicates that SLC38A7 could have an important function for the reuptake and recycling of glutamate."
> "Q8R3Z5-1","RefSeq","NP_112450.1","29212769","Data show that mutant variant V156A results in instability of protein subdomains of beta1a subunit leading to a phenotype of Ca(2+) dysregulation that partly resembles that of other malignant hypertension-linked mutations of DHPR alpha1S subunit."
> "Q8R3Z5-1","RefSeq","NP_112450.1","28351836","Structural and biophysical analyses of the skeletal dihydropyridine receptor beta subunit beta1a reveal critical roles of domain interactions for stability."
2584a3583,3587
> "Q99P72-2","RefSeq","NP_918942.1","30019429","While Nogo-B depletion inhibited tumor angiogenesis, Nogo-B overexpression promoted tumor angiogenesis in a tumor xenograft subcutaneous model of hepatocellular carcinoma."
> "Q99P72-2","RefSeq","NP_918942.1","30055160","These data show for the first time with genetic evidence that Nogo specifically expressed by oligodendrocytes restricts compensatory sprouting after CNS injury."
> "Q99P72-2","RefSeq","NP_918942.1","30051920","Results demonstrate a marked upregulation of the Nogo-A receptor sphingosine 1-phosphate receptor 2 in blood vessels following oxygen-induced retinopathy, while Nogo-A is abundantly expressed in surrounding glial cells. Acute inhibition of Nogo-A with function-blocking antibody 11C7 significantly improved vascular regeneration and consequently prevented pathological pre-retinal angiogenesis."
> "Q99P72-2","RefSeq","NP_918942.1","30040841","Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits Publication Status: Online-Only"
> "Q99P72-2","RefSeq","NP_918942.1","12225863","Expression by growing axons in the developing nervous system"
2587a3591,3592
> "P48026-1","RefSeq","NP_033147.1","29715464","SAT1 activation plays a key role in cold and beta3-AR agonist-induced beige adipocyte biogenesis and low-grade inflammation."
> "P48026-1","RefSeq","NP_033147.1","25390069","Enhanced SSAT expression by proximal tubule epithelial cells leads to tubular damage, and its deficiency reduces the severity of renal I/R injury through reduction of cellular damage and modulation of the innate immune response Publication Status: Online-Only"
2594a3600
> "Q8R3P2-1","RefSeq","NP_076231.1","16923970","Deltex can act as a negative regulator of Notch signals in T cells but that endogenous levels of Deltex1 and Deltex2 are not important for regulating Notch signals during thymocyte development"
2609a3616,3617
> "O35973-1","RefSeq","NP_035195.2","30242505","Autonomous clock in the rostral and caudal part of the habenula requires integrity of circadian genes Per1/2 to tick, and light information or suprachiasmic nuclei innervation to keep synchrony."
> "O35973-1","RefSeq","NP_035195.2","30127461","Hippocampal Per1 is critical for long-term memory formation. Publication Status: Online-Only"
2613a3622,3626
> "Q8BH43-1","RefSeq","NP_700472.1","29915352","WAVE2/c-Abl survival signal required at the hematopoietic stem cell (HSC) fetal liver to marrow transition that confers fitness to the HSC for marrow hematopoiesis Publication Status: Online-Only"
> "Q8BH43-1","RefSeq","NP_700472.1","29162704","TrkC signals to the podocyte actin cytoskeleton to induce migration by phosphorylating WAVE2 Erk dependently. This signaling mechanism may be important for TrkC-mediated cytoskeletal dynamics in podocyte disease."
> "Q8BH43-1","RefSeq","NP_700472.1","27278019","Rho family GTPases use the I-BAR proteins, IRSp53 (also known as BAIAP2), IRTKS and Pinkbar, as a central mechanism to modulate cell morphology."
> "Q8BH43-1","RefSeq","NP_700472.1","27095595","Data show that the primary effect of costimulation blockade was to decrease recruitment of the activator of actin nucleation WAVE2 (Wiskott-Aldrich syndrome protein family member protein 2) and cofilin (actin-severing protein) to F-actin. Publication Status: Online-Only"
> "Q8BH43-1","RefSeq","NP_700472.1","12589062","Scar2 and the Arp2/3 complex appear to be involved in the establishment and maintenance of Golgi polarity during directed migration"
2618,2624d3630
< "Q8VHL0-1","RefSeq","NP_001164482.1","27914708","Functional deficiency of all UTs caused a urea-selective urine-concentrating defect with little physiological abnormality in extrarenal organs."
< "Q8VHL0-1","RefSeq","NP_001164482.1","27091563","These results demonstrate that the descending thin limb (DTL) of the intermediate loop is composed of type I epithelium and expresses both UT-A2. The functional role of the DTL of the intermediate loop may be distinct from the short or long loops."
< "Q8VHL0-1","RefSeq","NP_001164482.1","26407594","We conclude that transgenic expression of UT-A1 restores basal urea permeability to the level in wild-type mice but does not restore vasopressin-stimulated levels of urea permeability. This information suggests that transgenic expression of UT-A1 alone in mice lacking UT-A1 and UT-A3 is sufficient to restore urine-concentrating ability"
< "Q8VHL0-1","RefSeq","NP_001164482.1","25298344","Studies indicate that urea transporter Slc14a1 UT-B is an indispensable transporter involved in maintaining physiological functions in different tissues. Review article"
< "Q8VHL0-1","RefSeq","NP_001164482.1","12965892","UT-B-deficient mice reveal that countercurrent exchange of urea in renal medullary vessels and red blood cells accounts for a major part of the kidney's concentrating ability and for the adaptation of renal urea handling during a high-protein intake."
< "Q8VHL0-1","RefSeq","NP_001164482.1","12952854","Potassium depletion is associated with reduced expression of UT-A1, UT-A3, and UT-B but increased expression of UT-A2"
< "Q8VHL0-1","RefSeq","NP_001164482.1","12133842","UT-B has a role in urinary concentrating ability in mice"
2643a3650,3652
> "Q05BQ1-1","RefSeq","NP_291086.2","24647940","These results provide genetic evidence for a specific role of IgSF9 in inhibitory synapse development/maintenance, presumably by its cell adhesion molecule-like activity."
> "Q05BQ1-1","RefSeq","NP_291086.2","18268009","Dendrite arborization phenotype was caused by off-target effects and that Dasm-1 is dispensable for hippocampal dendrite arborization"
> "Q05BQ1-1","RefSeq","NP_291086.2","15755926","Review. Dasm1, a protein likely to function as a neuronal cell-surface receptor, plays an important role in both shaping the dendritic tree and affecting the fraction of electrically active glutamatergic synapses. Review article Publication Status: Online-Only"
2649,2654c3658,3664
< "Q2Q5T5-1","RefSeq","NP_001170939.1","29581287","Genetic deletion of Myomixer in satellite cells abolishes satellite cell fusion and prevents muscle regeneration, resulting in severe muscle degeneration after injury."
< "Q2Q5T5-1","RefSeq","NP_001170939.1","28569755","Myomerger is a fundamental myoblast fusion protein with roles in skeletal muscle development Publication Status: Online-Only"
< "Q2Q5T5-1","RefSeq","NP_001170939.1","28569745","Minion is a novel microprotein required for muscle development Publication Status: Online-Only"
< "Q2Q5T5-1","RefSeq","NP_001170939.1","28386024","The Myomixer-Myomaker pair controls the critical step in myofiber formation during muscle development."
< "Q2Q5T5-1","RefSeq","NP_001170939.1","28637957","Gm7325, as a novel MyoD-target gene, is specifically induced in activated satellite cells, and may have an important role in skeletal myogenesis."
< "Q2Q5T5-1","RefSeq","NP_001170939.1","16331322","The expression of ESGP is consistent with the expression of Oct-4 during embryonic development.Forced expression of ESGP is not indispensable for the effect of Oct-4 on ES cell self-renewal, and does not affect the differentiation to three germ layers."
---
> "Q9Z307-1","RefSeq","NP_034734.3","29897283","That Nedd4-2 binds to Kir5.1 at the phosphothreonine motif of the COOH terminus, and the association of Nedd4-2 with Kir5.1 facilitates the ubiquitination of Kir4.1, thereby regulating its plasma expression in the distal convoluted tubule"
> "Q9Z307-1","RefSeq","NP_034734.3","28577853","HNF1beta renal knockout mouse exhibits down-regulation of Kcnj16.Thus, HNF1beta is a transcriptional activator of Kcnj16."
> "Q9Z307-1","RefSeq","NP_034734.3","26879293","Results demonstrate that, in addition to astrocytes, oligodendrocytes express both homomeric Kir4.1 and heteromeric Kir4.1/Kir5.1 channels."
> "Q9Z307-1","RefSeq","NP_034734.3","27376812","Down-regulation of Kir5.1 is associated with the decline in auditory function in aging mice."
> "Q9Z307-1","RefSeq","NP_034734.3","15310750","Kir4.1/5.1 and Kir4.1 expression appeared to occur only in astrocytes, specifically in the membrane domains facing the pia mater and blood vessels or in the processes surrounding synapses."
> "P47931-1","RefSeq","NP_032072.1","30995923","This study identified Sp1 as the critical transcription factor regulating activation of the FST promoter in cav-1 KO MC through binding to a region within 123 bp of the transcription start site. Publication Status: Online-Only"
> "P47931-1","RefSeq","NP_032072.1","20032047","The FST288-only isoform is sufficient for development. Loss of FST303 and FST315 isoforms results in fertility defects that resemble activin hyperactivity and premature ovarian failure."
2655a3666,3669
> "Q61644-1","RefSeq","NP_848142.1","29028184","Overall, the global native-KCC2 interactome and subsequent characterization revealed PACSIN1 as a novel and potent negative regulator of KCC2. Publication Status: Online-Only"
> "Q61644-1","RefSeq","NP_848142.1","27488904","Structure and function analysis reveals a requirement for the PACSIN1 F-BAR and SH3 domains in controlling NMDA receptor-dependent processes. Publication Status: Online-Only"
> "Q61644-1","RefSeq","NP_848142.1","24751538","Syndapin I functions reflected direct, SH3 domain-mediated associations and functional interactions with ProSAP1/Shank2."
> "Q61644-1","RefSeq","NP_848142.1","24509844","The SdpI-binding site was mapped to a proline-rich sequence of 22 amino acids within the intracellular loop of GlyRbeta."
2660,2663c3674,3677
< "Q5NBU8-1","RefSeq","NP_001032802.2","29132171","Macrophages activated by metabolic endotoxemia infiltrated into islets and produced IFNbeta, which induced beta-cell apoptosis by increasing the expression of Xaf1."
< "Q5NBU8-1","RefSeq","NP_001032802.2","27097110","XAF1 may be a candidate tumor suppressor in neuroblastoma"
< "Q5NBU8-1","RefSeq","NP_001032802.2","18192275","Interferon gamma induces XAF1 and Noxa expression and potentiates apoptosis by STAT3 activation"
< "Q5NBU8-1","RefSeq","NP_001032802.2","18544999","XAF1 possesses a potential antiangiogenesis effect. Suppressed expression of Tie-1, Ang-1, Ang-2 and c-Myc may be mechanistically responsible for the observed antiangiogenesis effect."
---
> "Q9Z2G6-1","RefSeq","NP_035474.1","30389665","This study not only establishes the importance of Sel1L-Hrd1 ERAD in the liver in the regulation of systemic energy metabolism, but also reveals a novel hepatic 'ERAD-Crebh-Fgf21' axis directly linking ER protein turnover to gene transcription and systemic metabolic regulation."
> "Q9Z2G6-1","RefSeq","NP_035474.1","28920918","Mice deficient for ERAD machinery component Sel1L develop central diabetes insipidus"
> "Q9Z2G6-1","RefSeq","NP_035474.1","20170518","Data suggest that Sel1l is essential for the growth and differentiation of endoderm-derived pancreatic epithelial cells during mouse embryonic development. Publication Status: Online-Only"
> "E9Q5N9-1","RefSeq","NP_950194.2","17693064","Highly related cDNAs Pbf and Gig1 interact with required element MyoD core enhancer; they represents a new family of DNA binding proteins that may be components of transciptional pathways that regulate a number of developmental and physiologic processes."
2678a3693,3704
> "Q5U4H9-1","RefSeq","NP_062718.2","28864529","Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation."
> "Q5U4H9-1","RefSeq","NP_062718.2","28375153","These studies demonstrate the importance of ferritin for the vectorial transfer of imported iron to mitochondria in developing red cells and of PCBP1 and NCOA4 in mediating iron flux through ferritin."
> "Q5U4H9-1","RefSeq","NP_062718.2","26776506","NCOA4 prevents iron accumulation and ensures efficient erythropoiesis, playing a central role in balancing iron levels in vivo."
> "Q5U4H9-1","RefSeq","NP_062718.2","25327288","Provide a new mechanism for selective autophagy of ferritin and reveal a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo"
> "Q5U4H9-1","RefSeq","NP_062718.2","20814820","High ARA70alpha inhibited cell proliferation, and that ARA70beta promotes proliferation in breast cancer."
> "Q5U4H9-1","RefSeq","NP_062718.2","20354146","Results demonstrate ubiquitous NcoA4 expression throughout development and suggest that this coactivator may play a role in modulating nuclear receptor activity, particularly that of the aryl hydrocarbon receptor, during development."
> "Q5U4H9-1","RefSeq","NP_062718.2","20167864","ARA70alpha functions as a tumor suppressor gene"
> "Q5U4H9-1","RefSeq","NP_062718.2","16110473","Data suggest that myostatin decreases the activity of androgen receptors (AR) by down-regulating the expression of ARA70, a known stimulating co-factor of AR"
> "Q8BNJ6-1","RefSeq","NP_001074793.1","28854365","KAR-mediated excitation of interneurons is contingent upon Neto1 because kainate yields comparable effects in Neto2 knockouts and wild-types but fails to excite interneurons or recruit inhibition in Neto1 knockouts."
> "Q8BNJ6-1","RefSeq","NP_001074793.1","28235897","Pain-transducing peripheral sensory neurons of the dorsal root ganglia (DRG) express kainate receptors (KARs), a subfamily of glutamate receptors that modulate neurite outgrowth and regulate glutamate release at the DRG-dorsal horn synapse."
> "Q8BNJ6-1","RefSeq","NP_001074793.1","26720915","These results establish critical roles for Neto auxiliary subunits controlling Kainate receptor properties and synaptic incorporation. Publication Status: Online-Only"
> "Q8BNJ6-1","RefSeq","NP_001074793.1","15464227","Btcl2 mRNA was observed restrictively in brain throughout embryonic and postnatal stages; expressed in the pontine nucleus and subplate, which are required for establishing the neuronal circuit formation."
2695,2696c3721,3723
< "Q9JKK7-1","RefSeq","NP_001033799.1","24746171","Role of Tmod2 protein's leucine rich repeat domain in the formation of neurite-like processes"
< "Q9JKK7-1","RefSeq","NP_001033799.1","12799133","Tmod2 plays a role in behavior, learning, memory, and synaptic plasticity."
---
> "Q9QYB8-1","RefSeq","NP_038486.2","29032200","Sez6l2 is one of the auxiliary subunits of the AMPA receptor and acts as a scaffolding protein to link GluR1 to ADD. Furthermore, Sez6l2 overexpression upregulates ADD phosphorylation, whereas siRNA-mediated downregulation of Sez612 prevents ADD phosphorylation, suggesting that Sez6l2 modulates AMPA-ADD signal transduction."
> "Q9QYB8-1","RefSeq","NP_038486.2","27480796","Study shows that a single injection of 3 pharmacologically distinct psychoactive drugs can modify spines in the nucleus accumbens within a day. beta-adducin is necessary for these effects. Study suggests that fine regulation of DARPP-32 phosphorylation is a major factor in mediating common effects on beta-adducin of various drugs with distinct or even opposite modes of action."
> "Q9QYB8-1","RefSeq","NP_038486.2","15728854","Beta-Adducin may play an important role in the cellular mechanisms underlying activity-dependent synaptic plasticity associated with learning and memory. Erratum:[J Neurosci. 2005 Apr 6;25(14):1 p following 3627]"
2701a3729,3730
> "O35975-1","RefSeq","NP_064299.2","29508376","This study shows that blocking the ART2.2/P2X7-system is essential to avoid a detrimental bias in functional CD4 T cell studies"
> "O35975-1","RefSeq","NP_064299.2","26209623","Data show that shedding of T Cell Ecto-ADP-ribosyltransferase ARTC2.2 alters its substrate profile."
2712a3742,3745
> "B9EHT4-1","RefSeq","NP_001074583.1","25572395","Collectively, our studies demonstrate that formation of an Elmo2.ClipR-59 complex plays an important role in myoblast fusion."
> "B9EHT4-1","RefSeq","NP_001074583.1","23482493","CLIPR-59 is involved in the stabilization of specific motor axons at the neuromuscular junction during mouse late embryogenesis and its role is crucial for mouse perinatal development. Erratum:[Development. 2013 Jun;140(11):2444]"
> "B9EHT4-1","RefSeq","NP_001074583.1","22689584","Because ClipR-59 also interacts with Akt and enhances the interaction between Akt and AS160, we suggest that ClipR-59 functions as a scaffold protein to facilitate Akt-mediated AS160 phosphorylation, thereby regulating glucose transport"
> "B9EHT4-1","RefSeq","NP_001074583.1","19139280","ClipR-59 functions as a scaffold protein that interacts with phospho-Akt and recruits active Akt on the membrane and may play an important role in adipocyte glucose transport."
2727a3761,3767
> "Q9D8T0-1","RefSeq","NP_079749.1","30996264","Study identified Fam3a, a cytokine-like protein, as a major Stat3 downstream effector in muscle stem cells and demonstrated that Fam3a is required for muscle stem cell commitment and skeletal muscle development. These findings indicate that Fam3a is a Stat3-regulated secreted factor that promotes muscle stem cell oxidative metabolism and differentiation. Publication Status: Online-Only"
> "Q9D8T0-1","RefSeq","NP_079749.1","28562339","FAM3A protects against liver IRI by activating Akt survival pathways, repressing inflammation and attenuating oxidative stress. Moreover, the protective effects of PPARgamma agonist(s) on liver IRI are dependent on FAM3A-ATP-Akt pathway."
> "Q9D8T0-1","RefSeq","NP_079749.1","28515350","FAM3A enhances the adipogenesis of preadipocytes by activating ATP-P2 receptor-Akt pathway. Under obese condition, a decrease in FAM3A expression in adipose tissues plays important roles in the development of adipose dysfunction and type 2 diabetes."
> "Q9D8T0-1","RefSeq","NP_079749.1","26939760","FAM3A has a protective role against cytotoxicity via regulating the CHOP-Wnt pathway in mitochondria."
> "Q9D8T0-1","RefSeq","NP_079749.1","24806753","FAM3A plays crucial roles in the regulation of glucose and lipid metabolism in the liver, where it activates the PI3K-Akt signaling pathway by way of a Ca(2+) /CaM-dependent mechanism"
> "Q9JLN6-1","RefSeq","NP_899222.1","28707394","The results suggest that CD19 controls the differentiation of marginal zone precursors to marginal zone B cells by regulating ADAM28-mediated Notch2 cleavage."
> "Q9JLN6-1","RefSeq","NP_899222.1","11724793","The authors report that recombinant human MDC-L (ADAM 28) protein with the disintegrin domain binds to the alpha(4)beta(1) integrin, and this binding may regulate the interaction between lymphocytes and leukocytes expressing alpha(4)beta(1)."
2746a3787
> "Q9CZM2-1","RefSeq","NP_079862.1","16608517","RPL15 promotes cell proliferation in gastric neoplasms Publication Status: Online-Only"
2749a3791,3793
> "Q60575-1","RefSeq","NP_032467.2","30126838","These data have supported the relevance of KIF1Bbeta in IGF1R transport, which may give new clue to the neuropathic pathogenesis."
> "Q60575-1","RefSeq","NP_032467.2","28637693","Pathogenic KIF1Bbeta mutations identified in neuroblastoma impair TRKA transport."
> "Q60575-1","RefSeq","NP_032467.2","27696585","Study demonstrates that mouse KIF1B is important for spindle assembly, chromosome congression, and mitochondrial distribution during oocyte maturation and early embryonic development."
2757c3801
< "P97863-1","RefSeq","NP_001106680.1","29965871","Results imply that the long noncoding RNA lnc158 positively modulates the transcription level of nuclear factor-IB mRNA, leading to the enhanced induction of oligodendrocytes."
---
> "A2ARM1-1","RefSeq","NP_080527.2","20826699","HPat1b localizes to P-bodies, while mPat1a-GFP is either found weakly in P-bodies or disperses P-bodies in a dominant-negative fashion."
2760a3805,3806
> "Q8JZR0-1","RefSeq","NP_082252.1","23767941","Acsl5 is a major activator of dietary long chain fatty acids , yet in Acsl5 KO mice residual ACS activity is sufficient for maintaining a normal long chain fatty acids absorption. Publication Status: Online-Only"
> "Q8JZR0-1","RefSeq","NP_082252.1","15051725","Acyl-CoA synthetase 2 has a role in fatty acid internalization and neurite outgrowth Erratum:[J Biol Chem. 2005 Mar 25;280(12):12064]"
2762,2764c3808,3809
< "Q8VDF2-1","RefSeq","NP_001104548.1","29859850","Findings suggest that Np95 plays an essential role in proliferation and differentiation of aNS/PCs through the regulation of tumor suppressor gene expression in adult neurogenesis."
< "Q8VDF2-1","RefSeq","NP_001104548.1","31024001","During limb development in mouse embryos, Uhrf1 is expressed in the undifferentiated autopodial mesoderm and in subsequent stages, expression becomes restricted to the interdigital mesoderm. By day 14 post coitum, interdigit regression is almost accomplished and Uhrf gene expression become restricted to zones of the joint formation. Publication Status: Online-Only"
< "Q8VDF2-1","RefSeq","NP_001104548.1","29968706","Study report that Uhrf1 forms a complex with the active trithorax group, the Setd1a/COMPASS complex, to maintain bivalent histone marks, particularly those associated with neuroectoderm and mesoderm specification. Publication Status: Online-Only"
---
> "O35737-1","RefSeq","NP_067485.1","26658939","These results define a novel contribution of Hnrnph1 to neurobehavioral dysfunction associated with dopaminergic neurotransmission. Publication Status: Online-Only"
> "O35737-1","RefSeq","NP_067485.1","25846207","HnRNP C and hnRNP H bind to the 3'-UTR of the circadian clock gene Period 2 (mPer2)."
2774,2777c3819,3821
< "Q6I6G8-1","RefSeq","NP_001001883.1","29260931","That circHECW2 regulated the EndoMT by directly binding to MIR30D, a significantly downregulated miRNA from miRNA profiling, which subsequently caused an increased expression of ATG5"
< "Q6I6G8-1","RefSeq","NP_001001883.1","27119228","Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity."
< "Q6I6G8-1","RefSeq","NP_001001883.1","25555806","NEDL2 positively regulates enteric neural precursor proliferation through the GDNF/Akt signaling pathway."
< "Q6I6G8-1","RefSeq","NP_001001883.1","15284439","Grk2 phosphorylates the C terminus of the Na-channel beta subunit and renders the channels insensitive to inhibition by Nedd4-2"
---
> "O70443-1","RefSeq","NP_034441.1","29088301","Present study suggest that Gnaz links the circadian clockwork-via dopamine acting on D4 receptors-to G protein-mediated signaling in intact but not diabetic retina Publication Status: Online-Only"
> "O70443-1","RefSeq","NP_034441.1","28419211","Galphaz plays a key role in beta-cell signaling that becomes dysfunctional in the type 1 diabetes setting, accelerating the death of beta-cells, which promotes further accumulation of immune cells in the pancreatic islets, and inhibiting a restorative proliferative response."
> "O70443-1","RefSeq","NP_034441.1","22457354","Deletion of GalphaZ protein protects against diet-induced glucose intolerance via expansion of beta-cell mass."
2780a3825,3829
> "Q8K4K3-1","RefSeq","NP_653134.2","30031847","The expression profiles of TRIB1, TRIB2, and TRIB3 in human and murine hematopoietic stem, progenitor and mature cells, and in human leukemia datasets have been mapped."
> "Q8K4K3-1","RefSeq","NP_653134.2","28364459","The absence of a change in hypocretin cell populations suggested that factors other than anti-TRIB2 antibody play a part in the loss of hypocretin neurons in narcolepsy. The increased anti-TRIB2 antibody after the destruction of hypocretin neurons suggest that anti-TRIB2 antibody in narcolepsy patients is the consequence rather than the inciting cause of hypocretin cell destruction."
> "Q8K4K3-1","RefSeq","NP_653134.2","17988908","Mice reconstituted with HSC cotransduced with HoxA9 and Trib2 had accelerated onset of AML compared to either gene alone"
> "Q8K4K3-1","RefSeq","NP_653134.2","17576771","Describe suppression of adipocyte differentiation by TRBs Trib1, Trib2, Trib3"
> "Q8K4K3-1","RefSeq","NP_653134.2","17097562","Data identify Tribbles homolog 2 as an oncogene that induces acute myelogenous leukemia through a mechanism involving inactivation of C/EBPalpha."
2793d3841
< "Q8BZM0-1","RefSeq","NP_001298065.1","18303015","KLHL12 specifically interacts with the D4 polymorphism, thereby building up a Cul3-E3 ligase complex with substrate specificity toward the D4 receptor"
2797a3846
> "Q9D8K8-1","RefSeq","NP_080818.1","19656490","Required for functional heme biosynthesis in erythroid cells. Possibly regulate ALAS2 through iron-sulfur cluster biogenesis."
2799,2801d3847
< "Q9QXS1-1","RefSeq","NP_001157012.1","18541706","Plectin 1b both forms a mitochondrial signaling platform and affects organelle shape and network formation by tethering mitochondria to intermediate filaments."
< "Q9QXS1-1","RefSeq","NP_001157012.1","17389230","We propose a model in which plectin acts as a universal mediator of desmin intermediate filament anchorage at the sarcolemma and Z-disks."
< "Q9QXS1-1","RefSeq","NP_001157012.1","12542521","Expression of plectin 1a, but not of its N-terminal fragment alone, or of a third alternative full length isoform (plectin 1), restored the reduced number of hemidesmosome-like stable anchoring contacts in cultured plectin-null keratinocytes"
2808,2811d3853
< "Q3ULW8-1","RefSeq","NP_001298079.1","30213852","These data indicate that Parp3 and Parp1 promote rearrangements with distinct phenotypes."
< "Q3ULW8-1","RefSeq","NP_001298079.1","26000965","We show that Poly(ADP)ribose polymerase 3 (Parp3), an enzyme recently implicated in DNA repair, contributes to antibody diversification by negatively regulating class switch recombination without affecting somatic hypermutation. Publication Status: Online-Only"
< "Q3ULW8-1","RefSeq","NP_001298079.1","21211721","PARP-3 has a role in chromosomal DNA double-strand break repair."
< "Q3ULW8-1","RefSeq","NP_001298079.1","12448766","We cloned and sequenced the cDNAs of the mouse PARP-3 (Adprt3) gene encoding poly(ADP-ribose) polymerase 3 and of the closely linked U3-55k gene coding for the U3 small nucleolar ribonucleoprotein complex-associated 55-kilodalton protein."
2818a3861,3870
> "Q9JKC6-1","RefSeq","NP_067291.1","26321141","Data suggest that common reprogramming mechanisms exist driving the conversion of lineage-distant somatic cell types to neurons and reveal a critical role for CEND1 in NEUROG2-driven astrocytic reprogramming."
> "Q9JKC6-1","RefSeq","NP_067291.1","24312406","Results suggest that functional interactions between BM88/Cend1, RanBPM and Dyrk1B affect the balance between cellular proliferation and differentiation in Neuro 2a cells Publication Status: Online-Only"
> "Q9JKC6-1","RefSeq","NP_067291.1","23658157","This study suggested that Cend1 is involved in Ahi1-associated hypothalamic neuronal differentiation in early development, giving us fresh insight into the mechanism behind the delayed development in Joubert syndrome."
> "Q9JKC6-1","RefSeq","NP_067291.1","20153830","Our results suggest that Cend1 is required for normal cerebellar development."
> "Q9JKC6-1","RefSeq","NP_067291.1","18499894","BM88/Cend1 participates in cell cycle control and neuronal differentiation mechanisms during neonatal SVZ neurogenesis and becomes crucial for the transition from neuroblasts to mature neurons when reaching high levels"
> "Q9JKC6-1","RefSeq","NP_067291.1","17971443","Results implicate BM88 in the synchronization of cell cycle exit and differentiation of neuronal precursors in the developing nervous system."
> "Q9JKC6-1","RefSeq","NP_067291.1","16949349","BM88 is widely expressed in the embryonic CNS and PNS, in both nestin-positive neuroepithelial cells and post-mitotic betaIII-tubulin positive neurons."
> "P06240-1","RefSeq","NP_034823.1","30232256","LCK nitration inhibits T cell activation, leading to reduced interleukin 2 (IL2) production and proliferation."
> "P06240-1","RefSeq","NP_034823.1","29062038","LCK cooperates with oncogenic FLT3-ITD in cellular transformation Publication Status: Online-Only"
> "P06240-1","RefSeq","NP_034823.1","28735895","A phosphosite within the SH2 Domain of Lck regulates its activation by CD45. A negative feedback loop that responds to signaling events tunes active Lck amounts and TCR sensitivity."
2820,2821d3871
< "P24161-1","RefSeq","NP_001106862.1","30356906","Study findings underline the important roles of p38 and STAT3 in the regulation of PD-L1 expression and prove that IFNalpha induces STAT3/p38-mediated expression of PD-L1 and thereby a reduced stimulatory ability of dendritic cells. Publication Status: Online-Only"
< "P24161-1","RefSeq","NP_001106862.1","28733484","ITAM sequence diversity is required for optimal TCR signal transduction and subsequent T cell maturation"
2824a3875,3877
> "Q30KP6-1","RefSeq","NP_898947.1","26987518","Function in sperm maturation"
> "Q30KP6-1","RefSeq","NP_898947.1","16023745","Defb41 and Defb42 are suggested to have a role in the antimicrobial protection of sperm and urogenital tract epithelia."
> "Q99NC0-1","RefSeq","NP_573514.1","22632831","Vgll1 interacts with TEAD4 in a manner similar to the transcription coactivators, as well as oncogenes YAP and TAZ, despite having a varied primary sequence. Vgll1 has the potential to promote cancer progression."
2827a3881,3884
> "Q9Z1G4-1","RefSeq","NP_058616.1","27512951","These results suggest that the Golgi complex may serve as a membrane platform for noncanonical autophagy where V-ATPase is a key player. Publication Status: Online-Only"
> "Q9Z1G4-1","RefSeq","NP_058616.1","26427489","Data suggest a mechanism by which betaA3/A1-crystallin regulates lysosomal function by modulating the activity of V-ATPase."
> "Q9Z1G4-1","RefSeq","NP_058616.1","24468901","Demonstrated that CRYBA1 coimmunoprecipitates with the ATP6V0A1/V0-ATPase a1 subunit"
> "Q9Z1G4-1","RefSeq","NP_058616.1","24165939","V-ATPase membrane domain would allow the exocytotic machinery to discriminate fully loaded and acidified vesicles from vesicles undergoing neurotransmitter reloading."
2832a3890,3895
> "A2AWR3-1","RefSeq","NP_001177226.1","24789282","Exome sequencing analysis between SM/J and A/J mice identified 4 genes (Itga6, Zak, Gpr155, and Mtx2) with nonsynonymous coding SNPs. These four genes might be candidate genes for type 2 diabetes caused by gene-gene interactions. Publication Status: Online-Only"
> "A2AWR3-1","RefSeq","NP_001177226.1","20537985","This study reports the structural organization of mouse GPR155 gene and the generation of five variants (Variants 1-5) of GPR155 mRNA, including so far unknown four variants."
> "Q9CQ37-1","RefSeq","NP_080300.1","18667844","Overexpression of UBE2T in NIH3T3 cells significantly promoted colony formation in mouse cell cultures."
> "Q8BST6-1","RefSeq","NP_291080.2","29674674","The functions of Pellino2 in the NLRP3 pathway are dependent on Pellino2 FHA and RING-like domains, with Pellino2 promoting the ubiquitination of NLRP3 during the priming phase of activation. Publication Status: Online-Only"
> "Q8BST6-1","RefSeq","NP_291080.2","22669975","Pellino 2 plays a critical role for TLR/IL-1R-mediated post-transcriptional control."
> "Q8BST6-1","RefSeq","NP_291080.2","12370331","Pellino-2 is a tissue-restricted component of a signaling pathway that couples the mouse pelle-like kinase/IL-1 receptor-associated kinase protein to IL-1- or lipopolysaccharide-dependent signaling."
2840a3904,3907
> "Q8VDG7-1","RefSeq","NP_598641.2","18024956","These results indicate that PAF-AH (II) is involved in the metabolism of esterified 8-isoprostaglandin F(2alpha) and protects tissue from oxidative stress-induced injury."
> "Q9WTW2-1","RefSeq","NP_065599.1","28356343","This study showed that Kcne3 deletion impairs muscle strength and flexibility in mice."
> "Q9WTW2-1","RefSeq","NP_065599.1","26985008","The findings uncover detailed molecular mechanisms underpinning a channelopathy-linked form of atrial fibrillation and emphasize the inevitability of considering extracardiac mechanisms in genetic arrhythmia syndromes."
> "Q9WTW2-1","RefSeq","NP_065599.1","26410412","KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation Review article"
2844a3912,3913
> "Q04736-1","RefSeq","NP_033561.1","25940087","Ganglioside GD3 enhances invasiveness of gliomas by forming a complex with PDGFRalpha and Yes Kinase."
> "Q04736-1","RefSeq","NP_033561.1","25301940","Serum also activates TEAD-dependent transcription in a time- and dose-dependent manner and we identify Inter-alpha-inhibitor (IalphaI) as a component in serum capable of activating the Yes/YAP/TEAD pathway"
2848a3918,3919
> "P30275-1","RefSeq","NP_034027.1","29753758","Mechanistic studies showed lncRNA n335586 promoted hepatocellular carcinoma (HCC) cells migration and invasion through facilitating the expression of its host gene mitochondrial creatine kinase (CKMT1A) by competitively binding miR-924."
> "P30275-1","RefSeq","NP_034027.1","24174293","Mitochondrial creatine kinase expression in hepatocellular carcinoma may be caused by hepatocarcinogenesis per se but not by loss of mitochondrial integrity, of which ASB9 could be a negative regulator"
2867,2870c3938,3941
< "P79621-1","RefSeq","NP_001289547.1","30327417","Results uncover an NFAT5-regulated mechanism that maintains CIITA and MHCII expression in macrophages and thus modulates their T lymphocyte priming capacity."
< "P79621-1","RefSeq","NP_001289547.1","30165873","This study provided evidence that CIITA is required for alpha-syn-induced MHCII expression and subsequent infiltration of peripheral immune cells in to the midbrain. Publication Status: Online-Only"
< "P79621-1","RefSeq","NP_001289547.1","29238041","Low CIITA expression is associated with cancer."
< "P79621-1","RefSeq","NP_001289547.1","28608405","Study found that CIITA exerts a highly restricted control over only the MHCII, H2-DO and H2-DM genes, in DC1 and DC2 cDC subsets, but not over other proposed targets"
---
> "Q923A2-1","RefSeq","NP_081687.2","20505367","Overexpression of mSpindly failed to enhance inactivation of SAC and acceleration of the meiotic process."
> "P08752-1","RefSeq","NP_032164.2","30804203","These results identify Galphai2 as the primary G protein alpha-subunit mediating the detection of volatile chemosignals in the apical layer of the vomeronasal organ."
> "P08752-1","RefSeq","NP_032164.2","28646160","These results delineate a role for Galphai2 in early thymocyte development and for Galphai2/3 in multiple aspects of T cell biology. Publication Status: Online-Only"
> "Q810S1-1","RefSeq","NP_080055.2","23900286","Functional characterization of the MCUb protein; shows that it inhibits mitochondrial calcium uptake"
2879a3951,3954
> "Q9D8F1-1","RefSeq","NP_082346.1","25153837","ALKBH4 is essential for the development of spermatocytes during the prophase of meiosis. Publication Status: Online-Only"
> "Q9D8F1-1","RefSeq","NP_082346.1","23673617","ALKBH4-dependent actin demethylation regulates actomyosin function by promoting actin-non-muscle myosin II interaction."
> "Q925H0-1","RefSeq","NP_031410.1","30074209","ASICs promote the inflammatory response and apoptosis of RAW 264.7 cells."
> "Q925H0-1","RefSeq","NP_031410.1","27402850","The potentiation of ASICs by quinine depends on the presence of the ASIC1a, ASIC2a subunits, but not ASIC1b, ASIC3 subunits. Furthermore, we have determined the amino acids in ASIC1a that are involved in the modulation of ASICs by pHi."
2882,2883d3956
< "Q91ZT5-1","RefSeq","NP_001288747.1","25356636","The enrichment of activated Cdc42 in SSeCKS-null leading edge filopodia correlated with recruitment of the Cdc42-specific guanine nucleotide exchange factor, Frabin. Publication Status: Online-Only"
< "Q91ZT5-1","RefSeq","NP_001288747.1","23171661","This study demonistrated that the disease-initiating event in CMT4H is loss of a Schwann cell-specific cellular function of Frabin/Fgd4."
2887a3961,3966
> "B2RUP2-1","RefSeq","NP_001009573.2","29884704","These results demonstrate that both C2 domains of Munc13-4 play critical roles in Ca(2+)-dependent exocytosis and cytotoxicity by regulating single-granule membrane fusion dynamics in immune cells"
> "B2RUP2-1","RefSeq","NP_001009573.2","29674495","We found that platelet-specific Munc13-4 KO mice had a reduction in airway hyper-responsiveness and eosinophilic inflammation. Taken together, our results indicate that Munc13-4-dependent platelet dense granule release plays essential roles in hemostasis, thrombosis and allergic inflammation."
> "B2RUP2-1","RefSeq","NP_001009573.2","29141910","In a model of systemic anaphylaxis, we found no difference between WT and Munc13-2 KO mice, but global and mast cells-specific Munc13-4 KO mice developed less hypothermia. We conclude that although Munc13-2 plays a minor role, Munc13-4 is essential for regulated exocytosis in mast cells"
> "B2RUP2-1","RefSeq","NP_001009573.2","18354201","Doc2alpha-Muunc13-4 system regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells"
> "B2RUP2-1","RefSeq","NP_001009573.2","17420270","Hemophagocytic lymphohistiocytosis phenotype is conditional, which suggests the existence of a specific infectious trigger of familial hemophagocytic lymphohistiocytosis in humans Erratum:[J Exp Med. 2008 Mar 17;205(3):737]"
> "Q8K0E1-1","RefSeq","NP_666300.1","29665387","The physiological role played by the complex KCTD15-GRP78 in the adipogenesis"
2888a3968,3975
> "Q8BUY8-1","RefSeq","NP_001156489.1","30926797","Manipulating the levels of Gprasp2 bidirectionally modulates the surface availability of mGluR5 and produces alterations in dendritic complexity, spine density and synaptic maturation. Publication Status: Online-Only"
> "Q8BUY8-1","RefSeq","NP_001156489.1","26901434","Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation. Publication Status: Online-Only"
> "Q8BUY8-1","RefSeq","NP_001156489.1","25657005","Present the First low resolution solution structure of myostatin-free and myostatin-bound states of GASP-1 and GASP-2"
> "Q9ER88-1","RefSeq","NP_075370.2","26306039","DAP3 plays important roles in mitochondrial function and dynamics"
> "Q9ER88-1","RefSeq","NP_075370.2","20381457","DAP3 is critical for TCR-mediated induction of apoptosis at the downstream of Nur77."
> "Q9ER88-1","RefSeq","NP_075370.2","17135360","Requirement for DAP3 in mitochondrial respiration was also revealed by oxygen consumption measurements using cultured cells treated with DAP3-specific small interfering RNA"
> "Q9ER88-1","RefSeq","NP_075370.2","17056041","DAP3 is reduced in both replicative and premature senescence induced by oxidative stress, and the DAP3 reduction induced by oxidative stress is observed mostly in a mitochondrial fraction."
> "Q9ER88-1","RefSeq","NP_075370.2","15175341","DAP3 has a role in the molecular pathway that culminates in fragmented mitochondria"
2903d3989
< "O88346-1","RefSeq","NP_001264832.1","29931346","Similar functional and histological phenotypes were observed in other human cohorts and two transgenic murine models (Tnnt1-/- and Tnnt1 c.505G>T). These findings have implications for emerging molecular therapies, including the suitably of TNNT1 gene replacement for newborns with 'Amish' nemaline myopathy or other TNNT1-associated myopathies."
2904a3991,3993
> "P31324-1","RefSeq","NP_035288.2","29518769","RNAi-mediated Prkar2b suppression resulted in MI-stage arrest during oocyte development, and these oocytes exhibited abnormal spindle formation and chromosome aggregation."
> "P31324-1","RefSeq","NP_035288.2","28409622","Data (including data from studies using knockout mice) suggest that S100A1 (S-100 calcium-binding protein A1, alpha chain) is involved in protein kinase A- (RIIalpha and RIIbeta)-dependent signaling resulting in nuclear redistribution/influx of HDAC4 (histone deacetylase 4) in skeletal muscle fibers."
> "P31324-1","RefSeq","NP_035288.2","27967236","Deficiency induces brownlike adipocytes in inguinal white adipose tissue, increases expression of uncoupling protein1 and other thermogenic genes"
2907a3997,4004
> "P47774-1","RefSeq","NP_031745.2","30824325","A critical role for CCR7-inducible lnc-Dpf3 in coupling epigenetic."
> "P47774-1","RefSeq","NP_031745.2","30210501","CRISPR/Cas9 Immunoengineering of Hoxb8-Immortalized Progenitor Cells for Revealing CCR7-Mediated Dendritic Cell Signaling and Migration Mechanisms in vivo. Publication Status: Online-Only"
> "P56477-1","RefSeq","NP_036187.1","30902986","The GEF-H1-IKKepsilon-IRF5 signaling axis functions independent of NOD-like receptors and is critically required for the recognition of intracellular peptidoglycans and host defenses against Listeria monocytogenes. Publication Status: Online-Only"
> "P56477-1","RefSeq","NP_036187.1","30457675","This study provides novel insights into the distinct and unique innate immune and immune gene regulatory program directed by IRF5."
> "P56477-1","RefSeq","NP_036187.1","29483597","IRF5 was a regulator of age-associated B cells in autoimmune settings"
> "P56477-1","RefSeq","NP_036187.1","17275788","We also provide evidence that this TLR synergy is mediated, at least in part, by activation of the transcription factor interferon regulatory factor 5 (IRF5)."
> "P56477-1","RefSeq","NP_036187.1","17360658","IRF5 is critical for antiviral immunity and for the induction of apoptosis, but not cell cycle arrest in response to DNA damage, and acts as a tumor suppressor on a pathway that may be distinct from that for p53."
> "P56477-1","RefSeq","NP_036187.1","15665823","Study identifies IRF-5 as a new, principal downstream regulator of the TLR-MyD88 signalling pathway and a potential target of therapeutic intervention to control harmful immune responses"
2919a4017,4020
> "O70628-1","RefSeq","NP_032830.3","29505961","Brain PDE9 is localized to preferentially regulate nuclear- and membrane-proximal pools of cGMP, and its function likely changes across the life span."
> "O70628-1","RefSeq","NP_032830.3","25799991","PDE9A can regulate cGMP signalling independent of the nitric oxide pathway, and its role in stress-induced heart disease suggests potential as a therapeutic target."
> "O70628-1","RefSeq","NP_032830.3","22596207","Data suggest that increases in hippocampal and amygdalar cGMP levels via blockade of PDE9 have prominent roles in consolidation of extinction learning (here, prevention of learning disorder due to cocaine neurotoxicity)."
> "O70628-1","RefSeq","NP_032830.3","9624146","This paper describes the human Pde9 gene but discusses the comparisons between the mouse and human Pde9 genes."
2934a4036,4042
> "Q91V14-1","RefSeq","NP_065066.2","30758780","KCC2 enhances spine density."
> "Q91V14-1","RefSeq","NP_065066.2","30874549","Study in mice shows that photo-depolarization of parvalbumin-positive (PV+) interneurons rapidly switches from an anti-ictal to a pro-ictal effect within a few seconds of seizure initiation. This switch can be prevented by overexpression of the neuronal potassium-chloride co-transporter KCC2 in principal cortical neurons. Publication Status: Online-Only"
> "Q91V14-1","RefSeq","NP_065066.2","30406192","That the KCC2a isoform is important for establishing proper breathing behavior at the time of birth Publication Status: Online-Only"
> "Q91V14-1","RefSeq","NP_065066.2","30224498","Increase in KCC2 function mitigated induction of aberrant high-frequency activity during seizures, highlighting depolarizing GABA as a key contributor to the pathological neuronal synchronization seen in epilepsy."
> "Q91V14-1","RefSeq","NP_065066.2","29949744","The amount of KCC2 expression decreased in the reticular nucleus by P60, and more so in mice expressing a mutant subunit of the nicotinic acetylcholine receptor."
> "Q91V14-1","RefSeq","NP_065066.2","11701957","Chromosomal localization of SLC12A5/Slc12a5, the human and mouse genes for the neuron-specific K(+)-Cl(-) cotransporter (KCC2) defines a new region of conserved homology. Erratum:[Cytogenet Cell Genet. 2002;98(2-3):232]"
> "Q62398-1","RefSeq","NP_031750.2","26377105","In Cnga2 knock-out mice there was an overproduction of Amyloid beta protein, tau hyper-phosphorylation, and behavioral abnormalities."
2949a4058,4061
> "Q9JHF5-1","RefSeq","NP_058617.3","29712939","A3 directly interacted with the GDP-bound forms of Rab7 and Rab27A. These findings reveal a novel role for the proton pump V-ATPase in secretory lysosome trafficking and an unexpected mechanistic link with Rab GTPases. Publication Status: Online-Only"
> "Q9JHF5-1","RefSeq","NP_058617.3","23908015","Here we show mice homozygous for R740S (R740S/R740S) of the Vacuolar-type H(+)-ATPases have more severe osteopetrosis and die by postnatal day 14"
> "P0C7T6-1","RefSeq","NP_001074399.1","17322884","Results provide genetic evidence that the selective neuropathology of Spinocerebellar ataxia type 1 arises from modulation of a core functional activity of ataxin-1"
> "P0C7T6-1","RefSeq","NP_001074399.1","16121196","Boat is an in vivo binding partner of ataxin-1 whose altered expression in Purkinje cells may contribute to their degeneration in causes spinocerebellar ataxia type 1 animals"
2955a4068,4072
> "O70479-1","RefSeq","NP_033421.3","28655611","ABETA 25-35 downregulated miR-137 and upregulated TNFAIP1 in cortical neurons and N2a cells."
> "O70479-1","RefSeq","NP_033421.3","27430312","Results demonstrated that TNFAIP1 was significantly upregulated by Abeta25-35 in mouse primary cortical neurons and N2a cells, and TNFAIP1 may be a key player that mediated Abeta25-35-induced neurotoxicity by inactivating the Akt/CREB signaling pathway, and in turn downregulating anti-apoptotic protein Bcl-2. Publication Status: Online-Only"
> "O70479-1","RefSeq","NP_033421.3","26969432","Study identifies Bacurd1/Kctd13 and Bacurd2/Tnfaip1 as interacting partners to RhoA GTPase proteins which influence the development of cortical neurons. Publication Status: Online-Only"
> "O70479-1","RefSeq","NP_033421.3","25888806","Bacurd2 influences the multipolar-to-bipolar transition of radially migrating neurons in a cell autonomous fashion. Bacurd2 and Rnd2 interact to promote radial migration within the embryonic cortex. Publication Status: Online-Only"
> "O70479-1","RefSeq","NP_033421.3","24737445","Estrogen and ERbeta regulate Tnfaip1 expression in mouse hippocampus."
2964a4082,4083
> "P97367-1","RefSeq","NP_034955.1","30190278","A previously unknown link between PcG proteins and downregulation of RA-related signals to mediate the phase transition of Meis2 transcriptional status during forelimb patterning, is reported. Publication Status: Online-Only"
> "P97367-1","RefSeq","NP_034955.1","29641989","Methylation impairs interaction with CRM1 without affecting PBX1 dimerization and thereby allows MEIS2 nuclear accumulation, a prerequisite for neuronal differentiation."
2966a4086,4091
> "D3Z1Q2-1","RefSeq","NP_001171202.1","30352741","MRAP2 in paraventricular MC4R neurons controls energy intake and expenditure."
> "D3Z1Q2-1","RefSeq","NP_001171202.1","28959025","MRAP2 is an important modulator of the energy homeostasis machinery that operates through the regulation of multiple GPCRs throughout the hypothalamus. Publication Status: Online-Only"
> "D3Z1Q2-1","RefSeq","NP_001171202.1","27106110","Mrap2 KO mice have a significant increase in body weight, with increased fat and lean mass, but without detectable changes in food intake or energy expenditure. Transcriptomic analysis showed significantly decreased expression of Sim1, Trh, Oxt and Crh within the paraventricular nucleus of Mrap2 KO mice. Circulating levels of both high-density and low-density lipoprotein were increased in Mrap2 KO mice."
> "D3Z1Q2-1","RefSeq","NP_001171202.1","26829592","Show that MRAP2 significantly and specifically inhibits PKR1 signaling. Publication Status: Online-Only"
> "D3Z1Q2-1","RefSeq","NP_001171202.1","23869016","Mrap2 interacts directly with melanocortin 4 receptor (Mc4r), a protein previously implicated in mammalian obesity, and it enhances Mc4r-mediated generation of the second messenger cyclic adenosine monophosphate, suggesting that alterations in Mc4r signaling may be one mechanism underlying the association between Mrap2 disruption and obesity. Erratum:[Science. 2013 Aug 30;341(6149):959]"
> "D3Z1Q2-1","RefSeq","NP_001171202.1","22366472","The data suggest that MRAPalpha is involved in MC2R targeting to the plasma membrane, while MRAPbeta may enhance ACTH-MC2R coupling to cAMP production."
2968a4094
> "Q8CGF6-1","RefSeq","NP_852065.2","22523538","We identify a novel LisH/WD40 repeat protein, tentatively named nemitin (neuronal enriched MAP interacting protein), as a potential regulator of MAP8-associated microtubule function"
2970a4097
> "Q75N62-1","RefSeq","NP_997651.1","16088918","GIMAP8 exerts an anti-apoptotic effect in the immune system and is involved in responses to infections"
2975c4102,4104
< "Q9QXA1-1","RefSeq","NP_062269.1","29609111","These results suggest that Lmo3 promotes anxiety-like behavior specifically in the BLA, possibly by altering Crhr1 expression."
---
> "P70175-1","RefSeq","NP_058027.1","27466188","Following the critical period NMDA receptor function was unaffected by loss of SAP102 but there was a reduction in the divergence of TC connectivity. These data suggest that changes in synaptic function early in development caused by mutations in SAP102 result in changes in network connectivity later in life."
> "P70175-1","RefSeq","NP_058027.1","12738960","SAP102 interacts with the PDZ-binding domain of Sec8, a member of the exocyst complex.  nteractions between the two proteins are involved in the delivery of N-methyl-D-aspartate receptors to the cell surface in heterologous cells and neurons."
> "Q8BNV8-1","RefSeq","NP_848911.2","18287072","PDC-TREM is responsible for IFN-alpha production in plasmacytoid dendritic cells."
2994a4124,4125
> "O35864-1","RefSeq","NP_038743.1","28292897","Genetic deletion of Csn5 in Apoe(-/-) mice markedly exacerbated atherosclerotic lesion formation."
> "O35864-1","RefSeq","NP_038743.1","25713139","COPS5 overexpression reduced spinophilin in both the cortex (19%, p < 0.05) and the hippocampus (20%, p < 0.05), leading to significant deficits in learning and memory skills"
3004d4134
< "Q8C9A2-3","RefSeq","NP_001158108.1","27108838","Mouse Endonuclease V shares substrate preferences with human EndoV by catalyzing cleavage at inosines in RNA and being inert towards inosines in DNA. Publication Status: Online-Only"
3015a4146,4149
> "Q8VBY2-1","RefSeq","NP_061371.2","26772170","The CaMKK-CaMKIalpha cascade is required for the axonal growth effect of Wnt5a during neuronal polarization. Publication Status: Online-Only"
> "Q8VBY2-1","RefSeq","NP_061371.2","25159322","Data (including data from knockout mice) suggest that up-regulation of Camkk1 and calcium signaling stimulates muscle growth via up-regulation of mTORC1 (mammalian target of rapamycin complex 1) signaling and muscle protein biosynthesis."
> "Q8VBY2-1","RefSeq","NP_061371.2","24101676","CaCaMKKalpha stimulates glucose uptake additively with insulin, and in insulin-resistant muscle, and alters the phosphorylation of TBC1D1/TBC1D4."
> "Q8VBY2-1","RefSeq","NP_061371.2","15150258","ERK activation and neurite outgrowth in response to depolarization are mediated by CaMKK activation of CaMKI"
3022,3023d4155
< "P81069-1","RefSeq","NP_084161.1","22862946","The findings identify the tetramer-forming GABPbeta2 as specific HSC regulators and potential therapeutic targets in treating LSC-based hematological malignancy."
< "P81069-1","RefSeq","NP_084161.1","18628204","GABPbeta2 has a distinct role in restraining B cell expansion and humoral responses."
3031,3035d4162
< "Q8K2P7-1","RefSeq","NP_001159928.1","29065407","The amino acid transporter gene Slc38a1 appears to be a novel gene responsive to hypoxic stress in a manner dependent on HIF-1alpha in brown adipocytes. In addition to in vitro studies, we showed that the Slc38a1 expression was enhanced in the brown adipose tissue of obesity model mice in vivo."
< "Q8K2P7-1","RefSeq","NP_001159928.1","28095293","Hence, pro-degenerative MAPK signaling functions upstream of SARM1 by limiting the levels of the essential axonal survival factor NMNAT2 to promote injury-dependent SARM1 activation. Publication Status: Online-Only"
< "Q8K2P7-1","RefSeq","NP_001159928.1","27373508","Changes in transporter expression likely reflect different amino acid requirements during development. Findings include the differential expression of SNAT1 in the inner and outer cells of the compacted morula and nuclear localisation of SNAT2 in the trophectoderm and placental lineages."
< "Q8K2P7-1","RefSeq","NP_001159928.1","25957749","Overexpression of X-box binding protein-1 led to a marked increase in luciferase activity in P19 cells transfected with the Slc38a1 reporter plasmid. These results suggest that theanine accelerates cellular proliferation and subsequent neuronal specification through a mechanism relevant to upregulation of Slc38a1 gene in undifferentiated neural progenitor cells"
< "Q8K2P7-1","RefSeq","NP_001159928.1","25673846","We found that MeCP2 acts as a microglia-specific transcriptional repressor of"
3057a4185,4187
> "Q61701-1","RefSeq","NP_001334107.1","31013625","We demonstrated HuD downregulation and HuB upregulation in DRG sensory neurons induced by diabetes, which might be correlated with altered post-transcriptional control of RNAs involved in the regulation of thermal hypoalgesia condition caused by the advanced diabetic neuropathy. Publication Status: Online-Only"
> "Q61701-1","RefSeq","NP_001334107.1","30014466","HuD enhanced p27 mRNA translation by interacting with both the 5'-untranslated region (UTR) and the 3'-UTR of p27 mRNA, and consequently suppressed cell cycle progression and growth of pancreatic neuroendocrine tumors."
> "Q3U213-1","RefSeq","NP_796285.2","15722415","Role in proximal t-haplotype mediated mouse sterility"
3061a4192
> "Q8R4V1-1","RefSeq","NP_083004.1","15143214","NFAM1 modulates B cell signaling through its immunoreceptor tyrosine-based activation motif, which regulates B cell development"
3069a4201,4202
> "P11985-1","RefSeq","NP_932772.1","19778998","Results support a role of Tcte3-3 in generation of sperm motility as well as in male germ cell differentiation"
> "Q9JLR9-1","RefSeq","NP_062788.1","16815968","Important role in stress protective programs in mitochondria."
3072a4206,4214
> "Q80TQ2-1","RefSeq","NP_775545.1","30964341","IL-33 mediated immunoregulation in pulmonary adenocarcinoma by improving DC-induced T cell proliferation by upregulating CYLD expression"
> "Q80TQ2-1","RefSeq","NP_775545.1","30554661","CYLD in the vasculature may be a novel therapeutic target, especially in the early preventive intervention against the initiation of age-related atherogenesis."
> "Q80TQ2-1","RefSeq","NP_775545.1","29291351","Our findings demonstrate that CYLD mitigates Nonalcoholic steatohepatitis severity and identify the CYLD-TAK1 axis as a promising therapeutic target for management of the disease."
> "Q80TQ2-1","RefSeq","NP_775545.1","29259980","The present results support the involvement of CYLD in the regulation of NF-kappaB inflammatory signaling induced by elevated glucose, implicating CYLD as a potential therapeutic target of diabetic nephropathy ."
> "Q80TQ2-1","RefSeq","NP_775545.1","17392286","A critical role for CYLD in regulating the basal activity of NF-kappaB and maintaining the naive phenotype and proper activation of B cells."
> "Q80TQ2-1","RefSeq","NP_775545.1","17053834","CYLD limits inflammation and tumorigenesis by regulating ubiquitination in vivo"
> "Q80TQ2-1","RefSeq","NP_775545.1","16713561","These data indicate that, depending on the external signals, Cyld can negatively regulate different NF-kappaB pathways; inactivation of TRAF2 controls survival and inflammation, while inhibition of Bcl-3 controls proliferation and tumor growth."
> "Q80TQ2-1","RefSeq","NP_775545.1","16501569","Identifed CYLD as a positive regulator of proximal T cell receptor signaling in thymocytes"
> "Q80TQ2-1","RefSeq","NP_775545.1","15226292","CYLD is induced by NF-kappaB"
3082a4225,4227
> "Q9D0I4-1","RefSeq","NP_080619.2","28504273","L. pneumophila Lpg1137 can shut down ER-mitochondria communication through cleavage of syntaxin 17 Publication Status: Online-Only"
> "Q9D0I4-1","RefSeq","NP_080619.2","27458136","Syntaxin-17 can be traced to the last eukaryotic common ancestor, hinting that the removal of damaged mitochondrial content may represent one of the earliest vesicle transport routes in the cell."
> "Q9D0I4-1","RefSeq","NP_080619.2","23217709","Study identifies syntaxin 17 (Stx17) as the autophagosomal SNARE required for fusion with the endosome/lysosome."
3089a4235,4238
> "Q5SSZ7-1","RefSeq","NP_001277430.1","30692207","Adrenocortical-specific loss of ZNRF3, but not RNF43, results in adrenal hyperplasia that depends on Porcupine-mediated Wnt ligand secretion."
> "Q5SSZ7-1","RefSeq","NP_001277430.1","29735715","XY mice lacking ZNRF3 exhibit complete or partial gonadal sex reversal, or related defects."
> "Q5SSZ7-1","RefSeq","NP_001277430.1","24349440","ZNRF3 binds RSPO1 and LGR5-RSPO1 with micromolar affinity via RSPO1 furin-like 1 (Fu1) domain. Publication Status: Online-Only"
> "Q5SSZ7-1","RefSeq","NP_001277430.1","22575959","Data suggest that R-spondin enhances Wnt signalling by inhibiting ZNRF3 Publication Status: Online-Only"
3097a4247,4250
> "Q5SZ99-1","RefSeq","NP_001025106.1","29753717","Our data suggest that TRIM38 plays a critical role in bone remodeling as a negative regulator of NF-kappaB in both osteoclast and osteoblast differentiation."
> "Q5SZ99-1","RefSeq","NP_001025106.1","26392463","Data show that tripartite motif-containing 38 protein (Trim38) deficiency potentiates toll like receptors TLR3/4-mediated signaling in primary immune cells."
> "Q5SZ99-1","RefSeq","NP_001025106.1","22539786","TRIM38 is a negative regulator for Toll like receptor (TLR) and retinoic acid-inducible gene (RIG)-I-mediated IFN-beta production by targeting Nck-associated protein NAP1 for ubiquitination and subsequent proteasome-mediated degradation."
> "Q5SZ99-1","RefSeq","NP_001025106.1","22323536","Ur findings defined a novel function for TRIM38 to prevent excessive TLR-induced inflammatory responses through proteasomal degradation of TRAF6."
3107,3108c4260,4263
< "Q7TQA1-1","RefSeq","NP_808259.2","28686733","Contrary to earlier predictions, neither the murine nor rat IGSF1-2 is secreted from heterologous or homologous cells. In addition, neither protein associates with the plasma membrane. Rather, IGSF1-2 appears to be retained in the endoplasmic reticulum. Publication Status: Online-Only"
< "Q7TQA1-1","RefSeq","NP_808259.2","28324000","Igsf1-deficient males exhibit normal serum TSH levels as well as normal numbers of TSH-expressing thyrotropes. However, pituitary expression of the TSH subunit genes and TSH protein content are reduced, as is expression of the receptor for thyrotropin-releasing hormone (TRH"
---
> "P34927-1","RefSeq","NP_033844.1","27405760","The key roles of the ManR and ASGR in controlling circulating levels of numerous glycoproteins critical for regulating reproductive hormones and blood coagulation."
> "P20334-1","RefSeq","NP_035742.1","30778712","Enhanced CD137 costimulation occurs in early cerebral ischemia and promotes T cell activation, which in turn upregulates inflammatory immune response and possibly exerting deleterious effects on cerebral ischemia."
> "P20334-1","RefSeq","NP_035742.1","30250465","These data suggest that 4-1BB signaling plays an important role in promoting AMs-mediated pro-fibrotic responses and pulmonary fibrosis. Publication Status: Online-Only"
> "P20334-1","RefSeq","NP_035742.1","29242193","M4-1BBL and Gal-9 act together to aid aggregation of m4-1BB monomers to efficiently initiate m4-1BB signaling."
3117c4272,4281
< "Q80XC3-1","RefSeq","NP_001074017.1","24239119","These findings identify RN-tre as the Rab5-GAP that spatiotemporally controls focal adhesion remodeling during chemotactic cell migration."
---
> "Q9D140-1","RefSeq","NP_081082.1","28095415","Ablation of KLK5 is not sufficient to rescue the lethal effect of LEKTI-deficiency. Double deficiency of both KLK5 and KLK7 completely rescues Netherton Syndrome-like phenotype. Publication Status: Online-Only"
> "Q9D140-1","RefSeq","NP_081082.1","26268952","The pruritogenic action of KLK5 may be primarily mediated by PAR2 receptors"
> "Q9D140-1","RefSeq","NP_081082.1","26390218","Findings illustrate the crucial role of protease regulation in skin homeostasis and inflammation, and establish KLK5 inhibition as a major therapeutic target for NS Publication Status: Online-Only"
> "Q9D140-1","RefSeq","NP_081082.1","17189908","The cloning and characteriazation of recombinant Klk5 is reported."
> "Q8HWE5-1","RefSeq","NP_715642.2","30337538","MILL2 has a unique structural architecture and physiological role, with binding to heparan sulfate proteoglycans on fibroblasts possibly regulating cellular recruitment in biological events. Publication Status: Online-Only"
> "Q8HWE5-1","RefSeq","NP_715642.2","26902929","Reversal of epigenetic silencing of MICA and MICB improves immune recognition and killing of Merkel cell carcinoma cells. Publication Status: Online-Only"
> "Q8HWE5-1","RefSeq","NP_715642.2","18560379","Our results suggest a role for the Mill proteins in cellular metabolism, with possible therapeutic significance."
> "Q8HWE5-1","RefSeq","NP_715642.2","16920948","Two members of the mouse MILL family, MILL1 and MILL2, are GPI-anchored glycoproteins associated with beta2-microglobulin (beta2m)"
> "Q8HWE5-1","RefSeq","NP_715642.2","15652646","Analysis of functional sites in NKG2D-MICA interaction in mouse and human"
> "Q8HWE5-1","RefSeq","NP_715642.2","12370446","Mill1 and Mill2 genes are predicted to encode membrane glycoproteins with domain organization essentially similar to that of MHC class I heavy chains."
3121a4286,4287
> "Q60954-1","RefSeq","NP_034919.1","29592525","Meis1 is specifically expressed in stroma and myofibroblasts of mouse. It is not required for kidney development, disease, or aging."
> "Q60954-1","RefSeq","NP_034919.1","29719258","PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21."
3124,3126d4289
< "Q3URY2-1","RefSeq","NP_001272845.1","26933123","The authors found that GEMC1-deficient mice are growth impaired, develop hydrocephaly with a high penetrance, and are infertile, due to defects in the formation of multiciliated cells in the brain, respiratory tract, and germline."
< "Q3URY2-1","RefSeq","NP_001272845.1","26882546","GemC1 directly transactivates the promoters of MCIDAS and FOXJ1."
< "Q3URY2-1","RefSeq","NP_001272845.1","26395491","Results suggest that Mcidas and GemC1 are key players in the generation of multiciliated ependymal cells of the adult neurogenic niche."
3133a4297,4301
> "Q80TV8-1","RefSeq","NP_083985.2","21937714","CLASP displays both plus end-binding and lattice-binding activities in nerve growth cones, and reveal that the two MT-binding activities regulate axon growth in an opposing manner"
> "Q61292-1","RefSeq","NP_032509.2","29599141","Age-related modulation of laminin beta1 versus beta2 chain expression changes the functional properties and phenotype of endothelial cells. The dysregulation of the extracellular matrix during vascular aging may contribute to age-associated impairment of organ function and fibrosis."
> "Q61292-1","RefSeq","NP_032509.2","29263159","Collectively, these data show the pathogenicity of LAMB2-S80R and provide the first evidence of genetic modification of Alport phenotypes by variation in another GBM component. This"
> "Q9QXE7-1","RefSeq","NP_065626.1","29794369","These results suggest that TBL1X is needed for the full activation of TRH and TSHbeta gene promoters by unliganded thyroid hormone receptors."
> "Q9QXE7-1","RefSeq","NP_065626.1","14980219","TBLR1 and TBL1 have roles in specific nuclear receptor-mediated gene activation events"
3150a4319,4322
> "P30987-1","RefSeq","NP_033351.1","30300909","This study shows that genetic depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor signaling prevents microvascular dysfunction in ischemia reperfusion injury"
> "P30987-1","RefSeq","NP_033351.1","27818280","Platelet GP6 and thromboxane A2 receptor have a role in promoting inflammatory macrophage phenotype in skin inflammation"
> "P30987-1","RefSeq","NP_033351.1","28165064","The results suggest that EP3 along with TP contributes to vasoconstrictor responses evoked by PGI2, and hence imply a novel mechanism for endothelial cyclooxygenase metabolites (which consist mainly of PGI2) in regulating vascular functions. Publication Status: Online-Only"
> "P30987-1","RefSeq","NP_033351.1","26957525","Genetic deletion of thromboxane receptor in adipose-derived stromal cells accelerated endothelial cell differentiation."
3163a4336
> "Q06890-1","RefSeq","NP_038520.2","30585162","The role of CLU in the emergence, recovery, and repair of gastric metaplasia after tamoxifen-induced acute oxyntic atrophy, is reported."
3184,3189c4357,4362
< "Q8K445-1","RefSeq","NP_700434.1","29985171","Results identify clarin-1 as a key organizer of IHC ribbon synapses, and suggest new treatment possibilities for USH3A patients."
< "Q8K445-1","RefSeq","NP_700434.1","26943149","Mutations that are Clrn1-/- biallelic cause visual defects when placed under A/J background."
< "Q8K445-1","RefSeq","NP_700434.1","19414487","Clrn1 is necessary for hair cell function and associated neural activation."
< "Q8K445-1","RefSeq","NP_700434.1","19423712","Clarin-1 has a role in the regulation and homeostasis of actin filaments"
< "Q8K445-1","RefSeq","NP_700434.1","17493778","Clarin-1 ribozyme induced apoptosis of cochlear hair cells and cells of stria vascularis. Suggest role for apoptosis in progressin of Usher syndrome type 3."
< "Q8K445-1","RefSeq","NP_700434.1","12080385","A role for clarin-1 in hair cell and photoreceptor cell synapses, as well as a common pathophysiological pathway for different Usher syndromes"
---
> "Q3URR7-1","RefSeq","NP_001276413.1","28846095","The pluripotency factor ZSCAN10 is poorly expressed in A-iPSCs and addition of ZSCAN10 to the four Yamanaka factors (OCT4, SOX2, KLF4 and c-MYC) during A-iPSC reprogramming normalizes ROS-glutathione homeostasis and the DNA damage response, and recovers genomic stability. Erratum:[Nat Cell Biol. 2019 Apr;21(4):531-532. PMID: 30643186]"
> "Q3URR7-1","RefSeq","NP_001276413.1","26592664","Our results clearly indicate that Zscan10 is dispensable for the ability of self-renewal and differentiation in ES cells."
> "Q3URR7-1","RefSeq","NP_001276413.1","25111779","A role for Zscan10 in either maintaining progenitor cell subpopulation or impacting on fate choice decisions thereof Erratum:[PLoS One. 2015;10(3):e0118766. PMID: 25741700] Publication Status: Online-Only"
> "Q3URR7-1","RefSeq","NP_001276413.1","22505416","Optimized crystals diffracted to 1.85 A resolution and belonged to space group I422, with unit-cell parameters a = 67.57, c = 87.54 A. A Matthews analysis indicated the presence of one Zfp206SCAN molecule per asymmetric unit"
> "Q3URR7-1","RefSeq","NP_001276413.1","17628018","Zfp206 is an embryonic transcription factor that plays a role in regulating pluripotency of embryonic stem cells."
> "Q3URR7-1","RefSeq","NP_001276413.1","16971461","Zfp206 is a regulator of embryonic stem cell differentiation that controls a set of genes expressed very early in development, most of which themselves appear to be regulators."
3215,3217c4388,4397
< "Q60575-1","RefSeq","NP_001277924.1","30126838","These data have supported the relevance of KIF1Bbeta in IGF1R transport, which may give new clue to the neuropathic pathogenesis."
< "Q60575-1","RefSeq","NP_001277924.1","28637693","Pathogenic KIF1Bbeta mutations identified in neuroblastoma impair TRKA transport."
< "Q60575-1","RefSeq","NP_001277924.1","27696585","Study demonstrates that mouse KIF1B is important for spindle assembly, chromosome congression, and mitochondrial distribution during oocyte maturation and early embryonic development."
---
> "Q8BMY7-1","RefSeq","NP_899107.1","24699552","Overexpression of different variants of Spink2 in D407 tissue culture cells increases their susceptibility to the apoptosis-inducing agent staurosporine in a manner consistent with the differential susceptibility between the DBA/2J and BALB/cByJ strains Publication Status: Online-Only"
> "Q8BMY7-1","RefSeq","NP_899107.1","21705336","SPINK2 is required for maintaining normal spermatogenesis and potentially regulates serine protease-mediated apoptosis in male germ cells."
> "P0C5J4-1","RefSeq","NP_001139802.1","29608652","This study demonstrated that the Knocking-out Gpr52 significantly reduces mutant HTT levels in the striatum and rescues Huntington's disease-associated behavioural phenotypes in a knock-in Huntington's disease mouse model expressing endogenous mutant Htt."
> "P0C5J4-1","RefSeq","NP_001139802.1","24587241","GPR52 has the potential of being a therapeutic psychiatric receptor. Publication Status: Online-Only"
> "E9Q9R9-1","RefSeq","NP_082002.1","25644602","Dlg5 is required for Hh-induced enrichment of Kif7 and Gli2 at the tip of the cilium but is dispensable for Gpr161 exit from the cilium and the consequent suppression of Gli3 processing into its repressor form"
> "E9Q9R9-1","RefSeq","NP_082002.1","25232112","DLG5 is a MAGUK protein that regulates spine formation, synaptogenesis, and synaptic transmission in cortical neurons."
> "E9Q9R9-1","RefSeq","NP_082002.1","23466739","Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis."
> "E9Q9R9-1","RefSeq","NP_082002.1","20436275","Data report that Discs large 5 (Dlg5), a member of the MAGUK family, is an interactor of CitK required for CitK polarization."
> "P62748-1","RefSeq","NP_057886.1","14739275","Visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner"
> "Q8JZP2-1","RefSeq","NP_038750.2","30046897","Syn III constitutes a crucial mediator of alpha-synuclein aggregation and toxicity and identify Syn III as a novel therapeutic target for Parkinson's disease"
3219a4400,4404
> "Q8BFQ3-1","RefSeq","NP_780702.1","30165600","Ogr1 deficiency was associated with a decrease in fibrosis formation."
> "Q8BFQ3-1","RefSeq","NP_780702.1","29655915","The signal transduction activity of OGR1 is regulated by pH-dependent internalization and recycling to the plasma membrane."
> "Q8BFQ3-1","RefSeq","NP_780702.1","29677517","GPR68 is an essential flow sensor in arteriolar endothelium and is a critical signaling component in cardiovascular pathophysiology"
> "Q8BFQ3-1","RefSeq","NP_780702.1","18847331","OGR1 induces an increase in Ca(i) in response to acidic medium and is a prime candidate for an osteoblast proton sensor."
> "Q8BFQ3-1","RefSeq","NP_780702.1","17576169","Regulator of G-protein signaling 18 acts as a negative regulator of the acidosis-induced osteoclastogenic OGR1/NFAT signaling pathway"
3223,3224d4407
< "Q3TUL7-1","RefSeq","NP_001159452.1","29907856","Disruption of Dcaf17 caused asymmetric acrosome capping, impaired nuclear compaction and abnormal round spermatid to elongated spermatid transition. For the first time, these data indicate that DCAF17 is essential for spermiogenesis. Erratum:[Sci Rep. 2018 Aug 1;8(1):11779. PMID: 30068992] Publication Status: Online-Only"
< "Q3TUL7-1","RefSeq","NP_001159452.1","29178422","A mouse model mimicking loss of function in exon 2 of Dcaf17 was generated using CRISPR/Cas9 and showed female subfertility and male infertility."
3236a4420,4422
> "P47801-1","RefSeq","NP_034258.1","16087880","Role of the adhesion molecule, EMP-1, as a biomarker of gefitinib clinical resistance, and further suggests a probable cross-talk between this molecule and the epidermal growth factor receptor signaling pathway"
> "P05531-1","RefSeq","NP_035855.1","20395201","X-linked lymphocyte-regulated protein pM1 (XMR), XLR, and SCP3 render tumor cells resistant to antitumor immunity"
> "P05531-1","RefSeq","NP_035855.1","12390899","Xlr (X linked, lymphocyte regulated) was expressed in oocytes throughout meiotic prophase I. These findings indicate a sex-specific expression of two closely related members of the Xlr gene family during meiotic prophase I."
3241a4428
> "Q8BX57-1","RefSeq","NP_840063.1","16135750","MONaKA modulates brain Na,K-ATPase by binding tightly to its beta1 and beta3 subunits, and may thereby participate in the regulation of electrical excitability and synaptic transmission."
3249c4436
< "Q3UVR3-1","RefSeq","NP_001020027.1","23141541","Study shows that TTBK2 is a dedicated regulator of the initiation of ciliogenesis in vivo; TTBK2 acts at the distal end of the basal body, where it promotes the removal of CP110, which caps the mother centriole, and promotes recruitment of intraflagellar transport proteins."
---
> "A2AGA4-1","RefSeq","NP_898986.2","21833011","RHBDL2 and soluble thrombomodulin were upregulated in ex vivo tissue culture of injured mouse skin. 3,4-Dichloroisocoumarin inhibited thrombomodulin production and wound healing; this was reversed by recombinant thrombomodulin in mice."
3251a4439,4440
> "Q9QXL2-1","RefSeq","NP_057914.2","29158259","Several key residues (i.e. Thr-1147, Leu-1152, Leu-1153, and Tyr-1154) at the C-terminal half of the KIF21A KBD peptide contact with the hydrophobic patch formed by Tyr-1176, Met-1209, Leu-1210, Leu-1213, and Leu-1248 from KANK1."
> "Q9QXL2-1","RefSeq","NP_057914.2","22465342","The diffuse and widespread expression of KIF21A in the developing human and mouse central and peripheral nervous system as well as in extraocular muscle does not account for the restricted ocular phenotype observed in Congenital fibrosis of the extraocular muscles type 1."
3253a4443,4453
> "Q80WM9-1","RefSeq","NP_849262.1","30483269","The HVEM ligand CD160 counterbalances stimulatory signals in highly activated and cytotoxic CD8(+) T effector cells. Publication Status: Online-Only"
> "Q80WM9-1","RefSeq","NP_849262.1","29339444","Mice with a conditional deletion of the LIGHT receptor HVEM (herpesvirus entry mediator) in keratinocytes phenocopied LIGHT-deficient mice in exhibiting reduced epidermal thickening and dermal collagen deposition in a model of atopic dermatitis driven by house dust mite allergen."
> "Q80WM9-1","RefSeq","NP_849262.1","28422285","LIGHT promote myeloid differentiation of Hematopoietic stem/progenitor cells via LIGHT receptor signaling."
> "Q80WM9-1","RefSeq","NP_849262.1","28864473","HVEM represents a critical signal for memory precursor effector cells and development of protective mucosal CD8 T cell memory"
> "Q80WM9-1","RefSeq","NP_849262.1","15178556","In graft arterial disease, HVEM was detected in SMCs stimulated by IFN-gamma. The LIGHT pathway plays important roles in the regulation not only of T-cell activation but also of SMC proliferation."
> "Q80WM9-1","RefSeq","NP_849262.1","15016549","Exerts a significant antiviral effect against HSV-1 infection in vivo."
> "Q3UHD9-1","RefSeq","NP_001287943.1","28404596","Depletion of PIKE-A in C2C12 myotubes diminished the inhibitory activities of TNF-alpha on mitochondrial respiration and lipid oxidation, whereas PIKE-A overexpression exacerbated these cellular responses."
> "Q3UHD9-1","RefSeq","NP_001287943.1","28096359","Dopamine and DOPAC were not changed in 3-mo-old mice but were decreased at 8 mo in the striatum of PIKE-KO mice compared with wild-type mice.  DA and DOPAC in hippocampus and substantia nigra were significantly decreased in 3-mo-old and 8-mo-old PIKE-KO mice as compared with wild-type mice. More severe motor defects in PIKE-KO and Fyn-KO mice than in wild-type mice exposed to alpha synuclein and MPTP."
> "Q3UHD9-1","RefSeq","NP_001287943.1","24449917","PIKE plays pivotal roles to advance oligodendroglia development and myelinogenesis through Akt/mTOR activation."
> "Q3UHD9-1","RefSeq","NP_001287943.1","20068140","PIKE knockout mice show augmented lipid oxidation, which is accompanied by enhanced AMPK phosphorylation in muscle and adipose tissue and is implicated in obesity and diabetes development."
> "Q3UHD9-1","RefSeq","NP_001287943.1","18469807","PIKE-L acts as a downstream survival effector for netrin-1 through UNC5B in the nervous system"
3265a4466
> "Q3ULW6-1","RefSeq","NP_083488.1","20068295","Data show that Ccdc33 encodes a putative peroxisomal protein and is predominantly expressed in male germ cells."
3270a4472,4477
> "P48794-1","RefSeq","NP_033267.2","23463525","PH20 is elevated in demyelinating lesions and that increased PH20 expression is sufficient to inhibit oligodendrocyte precursor cell maturation and remyelination."
> "P48794-1","RefSeq","NP_033267.2","22362218","ACR or PRSS21 or both may function cooperatively with SPAM1 in sperm/cumulus penetration"
> "P48794-1","RefSeq","NP_033267.2","19926939","The data from this paper suggests that the hyaluronan-degrading activity of the sperm hyaluronidase SPAM1 may not be required for fertilization, at least in the mouse."
> "P48794-1","RefSeq","NP_033267.2","19605784","SPAM1 may function in sperm entry into the cumulus and sperm penetration through the cumulus matrix."
> "P48794-1","RefSeq","NP_033267.2","12065596","Sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg"
> "P48794-1","RefSeq","NP_033267.2","11845284","Entrapment of spontaneous Spam1 mutations, owing to recombination suppression near the Robertsonion translocation junctions, is proposed as the major underlying defect of the sperm dysfunction."
3272,3275c4479,4488
< "Q9JMH6-1","RefSeq","NP_001035988.1","30805084","TXNRD1 inhibition augments hyperoxia-induced glutathione-dependent antioxidant responses in neonatal mice. Publication Status: Online-Only"
< "Q9JMH6-1","RefSeq","NP_001035988.1","29749372","Study in transgenic mice finds that T-cell activation is linked to a drastic downregulation of Txnip and an increase in Txn1/Txnrd1 expression, which is absolutely required for synthesis of 2'-deoxyribonucleotides during T-cell metabolic reprogramming. Txnrd1 is critical for expansion of the activated T-cell population during viral and parasite infection. Publication Status: Online-Only"
< "Q9JMH6-1","RefSeq","NP_001035988.1","28775321","We have identified a novel molecular axis which functionally acts in skeletal muscle myogenesis through the modulation of the antioxidant enzyme TrxR1 by miR-23 Publication Status: Online-Only"
< "Q9JMH6-1","RefSeq","NP_001035988.1","28686716","GSR is not essential for the maintenance of antioxidant defenses in mouse cochlea; the thioredoxin/thioredoxin reductase system can probably operate as a functional backup for GSR. Publication Status: Online-Only"
---
> "Q8R066-1","RefSeq","NP_080437.2","27086950","CTRP4 plays an important role in inflammation and inflammation-associated colon tumorigenesis."
> "Q8R066-1","RefSeq","NP_080437.2","24366864","These results establish CTRP4 as a novel nutrient-responsive central regulator of food intake and energy balance."
> "Q80XA0-1","RefSeq","NP_722471.2","12204283","Mouse hole is not expressed in the developing heart, although it does share neural expression seen in the chick."
> "Q99JB8-1","RefSeq","NP_112019.2","29202928","The authors show that muscle cells of syndapin III knockout mice show severe reductions of caveolae reminiscent of human caveolinopathies. The membrane-shaping protein syndapin III is crucial for caveolar invagination and gene knockout rendered the cells sensitive to membrane tensions. Publication Status: Online-Only"
> "Q99JB8-1","RefSeq","NP_112019.2","24500282","Show that in neuroendocrine chromaffin cells fusion pore expansion and catecholamine release are limited specifically by mutation of syndapin 3."
> "Q99JB8-1","RefSeq","NP_112019.2","22573331","Rigidity of wedge loop in PACSIN 3 protein is a key factor in dictating diameters of tubules"
> "Q99JB8-1","RefSeq","NP_112019.2","22297988","Crystal of PACSIN 3 (1-341) diffracted to 2.6 A resolution and belonged to space group P2(1), with unit-cell parameters a = 46.9, b = 54.7, c = 193.7 A, alpha = 90, beta = 96.9, gamma = 90 degrees"
> "Q99JB8-1","RefSeq","NP_112019.2","16627472","PACSIN 3 specifically affects the endocytosis of TRPV4, thereby modulating the subcellular localization"
> "Q8CBY1-1","RefSeq","NP_083242.1","24799716","Samd4 has a role in leanness, myopathy, uncoupled mitochondrial respiration, and regulation of mTORC1 signaling"
> "Q8CBY1-1","RefSeq","NP_083242.1","16221671","Smaug 1 has a role in RNA granule formation and translation regulation in neurons"
3285a4499,4500
> "Q62252-1","RefSeq","NP_035579.1","18492746","MRBMY protein can bind to the testis and sperm-specific spa17 mRNA."
> "Q62252-1","RefSeq","NP_035579.1","17971504","Spa17 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
3293,3305c4508,4512
< "P28574-1","RefSeq","NP_032584.2","30403691","MAX associated with DNA methyltransferases (DNMTs) and the histone methyltransferase SETDB1 cooperatively control germ cell-related gene expression in embryonic stem cells. Publication Status: Online-Only"
< "P28574-1","RefSeq","NP_032584.2","30126925","We also describe that B lymphocytes lacking Myc, Max, or both show upregulation of signaling pathways associated with the B-cell receptor. These data suggest that c-Myc/Max heterodimers are not essential for the initiation of a subset of important biological processes in B lymphocytes, but are required for fine-tuning the initial response after activation."
< "P28574-1","RefSeq","NP_032584.2","28220481","Studies suggest that inducible MYC Associated Factor X (MAX) knockout embryonic stem cells (ESCs) provide an excellent platform for exploring the molecular mechanisms of meiosis initiation. Review article"
< "P28574-1","RefSeq","NP_032584.2","27025988","MAX is a new regulator of meiotic onset. Publication Status: Online-Only"
< "O88508-1","RefSeq","NP_001258682.1","31015495","Study of mice carrying a point mutation (Dnmt3aD329A) in the DNMT3A-PWWP domain, revealed that it is gain of function mutation and results in progressive DNA hypermethylation across domains marked by H3K27me3 and bivalent chromatin and de-repression of developmental regulatory genes in adult hypothalamus that manifests phenotypically as dominant postnatal growth retardation. Publication Status: Online-Only"
< "O88508-1","RefSeq","NP_001258682.1","12138111","These findings suggest that Dnmt3a and Dnmt3a2 may have distinct DNA targets and different functions in development."
< "Q80XE1-2","RefSeq","NP_001013459.1","29118104","Olfactory-specific Ric-8b knock-out mice of mixed sex do not express the Galphaolf protein in the olfactory epithelium. The mature olfactory sensory neuron layer is reduced and cell death increased. These mice have an impaired sense of smell. Ric-8b is essential for olfactory function, and it may also be essential for Galphaolf-dependent functions in the brain. Erratum:[J Neurosci. 2018 Jan 24;38(4):1054. PMID: 31329690]"
< "Q80XE1-2","RefSeq","NP_001013459.1","26062014","Data show that the localization of maternally expressed RIC8 protein is highly dynamic and is dependent on the stage of folliculogenesis, oogenesis and cleavage, and imply that it may have a regulatory function in mammalian gametogenesis. Publication Status: Online-Only"
< "Q80XE1-2","RefSeq","NP_001013459.1","24585571","Results indicate that a functional N-terminus in C/EBPbeta-LAP* is required for interacting with SWI/SNF and for Ric-8B gene repression in osteoblasts."
< "Q80XE1-2","RefSeq","NP_001013459.1","24134321","A new role of Ric-8B in the crosstalk of two distinct G protein signaling pathways, which are possibly involved in a part of mechanisms of chronic heart failure."
< "Q80XE1-2","RefSeq","NP_001013459.1","20133939","Ric-8B plays a critical and specific role in the control of G alpha(s) protein levels by modulating G alpha(s) ubiquitination and positively regulates G(s) signaling"
< "Q80XE1-2","RefSeq","NP_001013459.1","18462949","Ric-8B interacts with two different olfactory G protein subunits and is implicated as an important protein in odorant signal transduction."
< "Q80XE1-2","RefSeq","NP_001013459.1","16754875","Results show that Ric-8B, a putative guanine nucleotide exchange factor for Galphaolf, promotes efficient heterologous expression of odorant receptors."
---
> "Q61900-1","RefSeq","NP_035552.1","24803544","In corporal smooth muscle cells from a sickle-cell-disese mouse, there was Smr3a up-regulation at a life stage prior to priapism, so the changes in gene expression are unlikely due to priapism, but rather due to the hypoxic conditions in SCD."
> "P30875-1","RefSeq","NP_033243.2","30261745","SSTR2 is mainly expressed in distal tubules and collecting ducts in murine kidneys, and the expression of SSTR2 decreases during cyst growth in two polycystic kidney disease mouse models"
> "P30875-1","RefSeq","NP_033243.2","29409919","Unpredictable chronic mild stress (UCMS) caused neuroendocrine changes, physical deteriorations, increased anxiety- and depressive-like behaviors and working memory impairments. sst2KO mice displayed behavioral alterations which were similar to stressed WT and exhibited exacerbated changes following UCMS exposure. The evaluations performed in the older mice showed significant long-term effects of UCMS exposure."
> "P30875-1","RefSeq","NP_033243.2","27986975","Both hippocampal sst2 and sst4 receptors selectively inhibit stress-induced HPA axis activation but mediate anxiolytic and antidepressive effects through distinct mechanisms."
> "P30875-1","RefSeq","NP_033243.2","25683115","Loss of sst2 from pancreatic tissues activates PI3K signaling via AKT, leading to activation of NF-kappaB, amplification of oncogenic KRAS signaling, increased expression of CXCL16, and pancreatic tumor formation."
3315a4523,4531
> "Q91WG1-1","RefSeq","NP_835183.1","29679236","CRTC2 modulates hepatic SREBP1c cleavage by controlling Insig2a expression during fasting Review article"
> "Q91WG1-1","RefSeq","NP_835183.1","29899135","Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis. Publication Status: Online-Only"
> "Q91WG1-1","RefSeq","NP_835183.1","28855656","These results suggest that PPARalpha is a trans-acting factor that enhances Insig2a gene expression, thereby suppressing SREBP-1c processing during fasting. Publication Status: Online-Only"
> "Q91WG1-1","RefSeq","NP_835183.1","28416613","These results indicate that HIF-mediated induction of Insig-2 and degradation of HMGCR are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia."
> "Q91WG1-1","RefSeq","NP_835183.1","27568546","INSIG2 is a negative regulator of SREBP, and acute glucocorticoid treatment decreased active SREBP during refeeding or in livers of Ob/Ob mice, both systems of elevated SREBP-1c-driven lipogenesis."
> "Q91WG1-1","RefSeq","NP_835183.1","16100574","Results define Insig proteins 1 and 2 as essential elements of the feedback inhibition system of cholesterol synthesis in mouse liver."
> "Q91WG1-1","RefSeq","NP_835183.1","15528275","A vitamin D response element in the murine Insig-2 promoter may have a role in the differentiation of 3T3-L1 preadipocytes"
> "Q91WG1-1","RefSeq","NP_835183.1","12624180","Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis."
> "P16305-1","RefSeq","NP_032094.2","29673739","The GABRA6 SNP rs3219151 has been significantly associated with alcohol dependence in studies on the Taiwanese Han, Korean, Finnish and South-western Native American populations."
3323a4540,4546
> "Q8BMS2-1","RefSeq","NP_598664.3","26165142","Mindin is a novel modulator of hepatic I/R injury through regulating inflammatory responses, as well as hepatocyte apoptosis and proliferation via inactivation of the Akt signaling pathway."
> "Q8BMS2-1","RefSeq","NP_598664.3","25751394","Mindin protects against vascular hyperplasia by suppression of abnormal VSMC proliferation, migration and phenotypic switching in an AKT-dependent manner."
> "Q8BMS2-1","RefSeq","NP_598664.3","24445216","Spondin 2 regulates hepatic lipid metabolism and alleviates hepatic steatosis, obesity, inflammation, and insulin resistance via its interaction with PPARalpha."
> "Q8BMS2-1","RefSeq","NP_598664.3","18818374","Mindin participates in integrin-dependent trafficking of eosinophils and can contribute to the severity of allergic airways disease."
> "Q8BMS2-1","RefSeq","NP_598664.3","18424748","Mindin plays an essential role in the host innate immune response to influenza virus infection and suggest that mindin may be used as an immune-enhancing agent in influenza infection."
> "Q8BMS2-1","RefSeq","NP_598664.3","16917498","Mindin-integrin interactions play a key role in regulating Rho GTPase expression in DCs and DC priming of T lymphocytes."
> "Q8BMS2-1","RefSeq","NP_598664.3","14691481","Mindin is a pattern-recognition molecule for microbial pathogens."
3325a4549,4550
> "P37040-1","RefSeq","NP_032924.1","27863990","Knockout of the cytochrome P450 reductase by CRISPR/Cas9 technology (POR(-/-)) in HEK293 cells overexpressing Nox4 or Nox5 did not interfere with ROS production in intact cells. However, POR(-/-) abolished the signal in NADPH-stimulated assays using membrane fractions from the very same cells. Moreover, membranes of rat smooth muscle cells treated with angiotensin II showed an increased NADPH-dependent signal with lucigen"
> "P37040-1","RefSeq","NP_032924.1","26898952","We observed that miR-378 modulates the oscillation amplitudes of Cdkn1a in the control of cell cycle and Por in the regulation of oxidation reduction by forming partnership with different circadian transcription factors Publication Status: Online-Only"
3329a4555,4557
> "P50172-1","RefSeq","NP_032314.2","29891135","Tis study shows that 11 beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis"
> "P50172-1","RefSeq","NP_032314.2","29062028","These data suggest that 11beta-HSD1 is not crucial for survival of experimental malaria, but alters its progression in a parasite strain-specific manner. Publication Status: Online-Only"
> "P50172-1","RefSeq","NP_032314.2","28749080","We envisage these data and models finding utility when investigating the muscle-specific functions of the 11beta-HSD1/G6PT/H6PDH triad."
3338a4567,4568
> "Q9D925-1","RefSeq","NP_081191.1","21444326","Immuno-neutralization of Lyzl4 protein in spermatozoa with its specific antibody significantly decreased in vitro fertilization percentage in a dose-dependent manner, suggesting that Lyzl4 might be important for fertilization"
> "Q99M96-1","RefSeq","NP_071727.2","15485929","Suppressor of tumorigenicity 7 (ST7) and nonmetastatic 23 (NM23) are direct targets of PRMT5-containing BRG1 and hBRM complexes"
3356a4587,4594
> "P31809-1","RefSeq","NP_001034275.1","31083261","In this study, a CEACAM-1 overexpression vector was constructed, and the effects of CC1 overexpression post CVB3 infection were analyzed. The results suggested that CC1 may promote CAR expression in cardiomyocytes after CVB3 infection, and CAR may be a potential target for CC1 to regulate the CVB3-induced process of myocardial injury. CC1 might regulate CAR expression by activating the CC1-SYK- TNF-[alpha] signaling axis."
> "P31809-1","RefSeq","NP_001034275.1","30674283","CEACAM1 negatively regulates RP105 signaling in monocytes by recruitment of SHP-1, resulting in the sequestration of pVAV1 and beta-actin from RP105. This novel pathway and regulation of IL-6 signaling by CEACAM1 defines a novel role for monocytes in the fever response of mice to LPS Publication Status: Online-Only"
> "P31809-1","RefSeq","NP_001034275.1","29746166","These results identify a crucial role for CEACAM1 in endothelial homeostasis of adult blood vessels."
> "P31809-1","RefSeq","NP_001034275.1","29907459","Study using NLRC5 deficient mice found that NLRC5 exacerbated renal injury by the development of postischemic renal inflammation and the induction of tubular epithelial cell apoptosis that was associated with, at least in part, the negative regulation of CEACAM1. This suggests that NLRC5 signaling in renal parenchymal cells plays the dominant role in mediating renal damage."
> "P31809-1","RefSeq","NP_001034275.1","29967450","Study concludes that CEACAM1 is an important regulator of virus-specific CD8+ T cell functions in mice and humans and represents a promising therapeutic target for modulating CD8+ T cells. Publication Status: Online-Only"
> "Q3U0P1-1","RefSeq","NP_001276774.1","29739757","The tumor suppression mechanisms of the BRCA1-PALB2 DNA damage response pathway."
> "Q3U0P1-1","RefSeq","NP_001276774.1","28240985","The findings demonstrate that RNF168 couples PALB2-dependent homologous recombination to H2A ubiquitylation to promote DNA repair and preserve genome integrity. Publication Status: Online-Only"
> "Q3U0P1-1","RefSeq","NP_001276774.1","20484223","A key function for PALB2 is to interact with and to build up appropriate communication between BRCA1 and BRCA2."
3363,3366d4600
< "Q99NE5-1","RefSeq","NP_444500.1","29891949","Postsynaptic RIM1 in hippocampal CA1 region is required for basal NMDAR-, but not AMPA receptor (AMPAR)-, mediated synaptic responses, and contributes to synaptic plasticity and hippocampus-dependent memory. Moreover, RIM1 levels in hippocampal neurons influence both the constitutive and regulated NMDAR trafficking, without affecting constitutive AMPAR trafficking. Publication Status: Online-Only"
< "Q99NE5-1","RefSeq","NP_444500.1","29606581","RIM C2B domains are constitutive PIP2-binding molecules that couple mechanisms for synaptic vesical priming."
< "Q99NE5-1","RefSeq","NP_444500.1","11797010","Required for presynaptic long-term potentiation."
< "Q99NE5-1","RefSeq","NP_444500.1","11797009","RIM1alpha interacts with several active zone molecules, including Munc13-1 and alpha-liprins, to form a protein scaffold in the presynaptic nerve terminal."
3371,3375d4604
< "Q6HA09-1","RefSeq","NP_001277932.1","28911209","Intracellular activation of Astl mediates pre-fertilization hardening of the zona pellucida."
< "Q6HA09-1","RefSeq","NP_001277932.1","28114310","Seven amino acid motif near Astl N-terminus is necessary and sufficient for cortical granule localization. Publication Status: Online-Only"
< "Q6HA09-1","RefSeq","NP_001277932.1","22472438","Ovastacin is a pioneer component of mouse cortical granules and plays a definitive role in the postfertilization block to sperm binding that ensures monospermic fertilization and successful development"
< "Q6HA09-1","RefSeq","NP_001277932.1","22206759","Data show that SAS1B/SAS1R (Sperm Acrosomal SLLP1 Binding/Sperm Acrosomal SLLP1 receptor) bound to sperm acrosomal protein SlLP1 with high affinity."
< "Q6HA09-1","RefSeq","NP_001277932.1","22275110","ASTL is dynamically expressed in the embryonic epithelium and in embryonic stem cells, suggesting an important function for the control of epithelial cell behavior during early development."
3385a4615,4616
> "O88455-1","RefSeq","NP_031882.1","28220990","Dhcr7 heterozygous mice made fewer ultrasonic vocalizations.  Increases of 7-DHC and expression of the serotonin transporter were observed in the compound mutant mice."
> "O88455-1","RefSeq","NP_031882.1","27066502","Studied the effect of 7-dehydrocholesterol reductase (Dhcr7) and identified signal pathways involved in regulation of embryonic palatogenesis. Expression changes of Dhcr7, Sonic Hedgehog (Shh), and bone morphogenetic protein-2 (Bmp2) were measured by RT-PCR and WB after Dhcr7 gene silencing and the addition of exogenous cholesterol."
3409a4641,4642
> "Q8BUM3-1","RefSeq","NP_796055.1","24265715","PTPN7 as a negative regulator of TNF-alpha expression and the inflammatory response in macrophages Publication Status: Online-Only"
> "Q8BUM3-1","RefSeq","NP_796055.1","19047375","Beta(2)AR stimulation on a B cell phosphorylates and inactivates HePTP in a Gs/cAMP/PKA-dependent manner to release bound p38 MAPK, making more available for phosphorylation and subsequent IgE regulation."
3420d4652
< "Q8C181-1","RefSeq","NP_780550.1","29735517","This study uncovers non-canonical functions of MBNL proteins (Mbnl1/2) that bind and promote the expression of miR-294 targets, including Cdkn1a and Tgfbr2, thereby opposing the role of miR-294 in regulating cell proliferation, apoptosis, and epithelial-mesenchymal transition (EMT)."
3424a4657
> "P86449-1","RefSeq","NP_001171329.1","19703589","We describe the identification and characterization of Trim43a, Trim43b, and Trim43c genes, whose expression are restricted to preimplantation stages and peak at the 8-cell to morula stage"
3428d4660
< "Q5F2L2-1","RefSeq","NP_001012535.1","23986452","Fut10 is involved in a unique alpha1,3-fucosyltransferase activity with stringent substrate specificity."
3435a4668,4670
> "P63141-1","RefSeq","NP_032443.3","30356053","Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations Publication Status: Online-Only"
> "P63141-1","RefSeq","NP_032443.3","27874088","G9a contributes to neuropathic pain development through epigenetic silencing of Kcna2 in the axotomized dorsal root ganglion. Publication Status: Online-Only"
> "Q3U3F9-1","RefSeq","NP_082241.1","27259691","These findings suggest an important role of GPR160 in regulating the entry of BCG into macrophages by targeting the ERK signaling pathway."
3439a4675
> "Q6DID5-1","RefSeq","NP_075920.4","15959530","Results suggest that MUM1 plays roles in the progression of B-cell lymphoma/leukemia by regulating the expression of various genes including MIG."
3452a4689
> "Q80ZM3-1","RefSeq","NP_796075.2","29352221","These results further indicate that METTL20-mediated protein methylation is not essential in humans but more likely modulates energy production during fasting or under other metabolic conditions where beta-oxidation is up-regulated. Publication Status: Online-Only"
3455a4693,4696
> "Q8R3G1-1","RefSeq","NP_666266.1","30305391","NIPP1 deletion abrogated PP1-mediated EZH2 dephosphorylation at two cyclin-dependent kinase sites (Thr-345/487), thereby generating hyperphosphorylated EZH2, which is a substrate for proteolytic degradation."
> "Q8R3G1-1","RefSeq","NP_666266.1","29042623","We conclude that NIPP1 is essential for mammalian spermatogenesis because it is indispensable for the proliferation and survival of progenitor germ cells, including (un)differentiated spermatogonia. Publication Status: Online-Only"
> "Q8R3G1-1","RefSeq","NP_666266.1","27068806","NIPP1 does not regulate the proliferation of hepatocytes but is a suppressor of biliary epithelial cell proliferation, including progenitor cells, in the adult liver."
> "Q8R3G1-1","RefSeq","NP_666266.1","15199142","NIPP1(-/-) embryos showed severely retarded growth at embryonic day 6.5 (E6.5) and were resorbed by E8.5. This early embryonic lethality was not associated with increased apoptosis but correlated with impaired cell proliferation."
3457a4699
> "Q3TRM8-1","RefSeq","NP_001193319.1","25904018","Hexokinase expression is highly enriched in neurons compared to astrocytes. Publication Status: Online-Only"
3476a4719
> "Q9D7V1-1","RefSeq","NP_082458.1","18641339","SH2D4A is dispensable for TCR signal transduction in T cells"
3480a4724,4727
> "P37238-1","RefSeq","NP_035276.2","30942395","It was confirmed that PRMT6 was involved in the process of adipocyte differentiation. In addition, PRMT6 interacted with, but did not methylate, PPARgamma. PRMT6 bound to the PPARresponsive regulatory element of the adipocyte Protein 2 (aP2) promoter in conjunction with PPARgamma and generated the repressive epigenetic mark arginine 2 on histone H3 asymmetric dimethylation, which suppressed aP2 gene expression."
> "P37238-1","RefSeq","NP_035276.2","30884812","Molecular docking analysis revealed that the inhibitory activity of these phenolic compounds over the early stages of adipogenesis exhibits a significant correlation (r = 0.7034; p = 0.005) with their binding affinity to the ligand-binding domain of PPARgamma. Publication Status: Online-Only"
> "P37238-1","RefSeq","NP_035276.2","30920877","Resveratrol displayed significant anti-adipogenic activities as exhibited by the ability to antagonize PPARgamma-dependent adipocyte differentiation, down-regulate genes involved in lipid metabolism, block cofactor recruitment to PPARgamma, and antagonize the effects of the PPARgamma agonist rosiglitazone. In contrast, genistein and daidzein functioned as PPARgamma agonists while also displaying pro-adipogenic activities. Erratum:[Environ Health Perspect. 2019 Oct;127(10):109002. PMID: 31647338]"
> "P37238-1","RefSeq","NP_035276.2","30813929","PPAR-gamma deficiency in vascular smooth muscle increases pulmonary vascular muscularization. Publication Status: Online-Only"
3492a4740
> "Q5GH67-1","RefSeq","NP_001011874.1","25231987","Unlike Xkr8, which is ubiquitously expressed, Xkr4 and Xkr9 expression is tissue-specific."
3509,3510d4756
< "O08791-1","RefSeq","NP_001106886.1","29869132","The caudo-ventral pallium is a novel pallial domain expressing Gdf10 and generating Ebf3-positive neurons of the medial amygdala."
< "O08791-1","RefSeq","NP_001106886.1","29563184","HSC cellular niches express Ebf3 that is required to create HSC niches, to inhibit their osteoblast differentiation, and to maintain spaces for HSCs."
3518a4765
> "O35738-1","RefSeq","NP_034766.2","29475398","Klf12 expression is down-regulated in kidney tissues of Pkd2f/f mice.  miR-20b-5p and miR-106a-5p directly target Klf12 mRNA by binding to the 3'-UTR of Klf12."
3524a4772,4774
> "Q9QY48-1","RefSeq","NP_064341.3","21390259","These data identify DNase 2 as the predominant DNase on the mammalian skin surface and indicate that its activity is primarily targeted to exogenous DNA. Publication Status: Online-Only"
> "Q9QY48-1","RefSeq","NP_064341.3","12944971","The DLAD-/- mice develop cataracts of the nucleus lentis, and their response to light on electroretinograms is severely reduced; these results indicate that DLAD is responsible for the degradation of nuclear DNA during lens cell differentiation"
> "Q9QY48-1","RefSeq","NP_064341.3","11700027","Gene lie head-to-head with the urate oxidase gene"
3528a4779
> "P97379-1","RefSeq","NP_035946.2","22357953","Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2."
3531d4781
< "Q9D824-1","RefSeq","NP_001153045.1","16690743","FIP1L1-PDGFRalpha activation requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent"
3535a4786,4787
> "Q8VHG0-1","RefSeq","NP_659127.1","24792439","Data indicate that in contrast to FMO2 and FMO4, FMO1 is highly expressed in metabolic tissues, including liver, kidney, white adipose tissue (WAT) and brown adipose tissue (BAT)."
> "Q8VHG0-1","RefSeq","NP_659127.1","19307449","Data show a compelling visual demonstration of the isoform-specific localization patterns of FMO1, -3, and -4 in the rat liver and kidney and the first evidence for expression of FMO4 at the protein level in mouse and human liver and kidney microsomes."
3541,3542c4793,4799
< "P61793-1","RefSeq","NP_034466.2","30622227","HEB may be required for a proper regulation of Lpar1 expression in the embryonic neocortical neuroblast cells."
< "P61793-1","RefSeq","NP_034466.2","29051083","Study shows that lysophosphatidic acid (LPA) propagates post-injury schwann cell (SC) dedifferentiation through lysophosphatidic acid 1 signaling. These data indicate that LPA may be a critical factor that shifts SCs towards a post-injury phenotype and contributes to the onset of Wallerian degeneration."
---
> "O88668-1","RefSeq","NP_035934.1","30295852","Effect of CREG1 on Ucp1 promoter activity was also stimulated by retinoic acid. These results strongly suggest that CREG1 plays an important role on the regulation of UCP1 expression and brown adipogenesis"
> "O88668-1","RefSeq","NP_035934.1","29684345","Transplantation of CREG-modified embryonic stem cells exhibits a favorable survival pattern in infarcted hearts, which translates into a substantial preservation of cardiac function after acute myocardial infarction."
> "O88668-1","RefSeq","NP_035934.1","28459882","Study demonstrated that haplodeficiency of Creg1 exacerbated high fat diet-induced obesity, insulin resistance and dyslipidemia. In addition, Creg1+/- mice showed increased systemic and adipose tissue inflammation, possibly through activation of the NF-kappaB pathway. Publication Status: Online-Only"
> "O88668-1","RefSeq","NP_035934.1","28062494","CREG is a novel mediator of vascular remodeling in response to Ang II."
> "O88668-1","RefSeq","NP_035934.1","18621046","Results show that CREG is a lysosomal protein that undergoes proteolytic maturation during biosynthesis, carries the mannose 6-phosphate recognition marker and depends on the interaction with M-6-P receptors for efficient delivery to lysosomes."
> "Q8BGD6-1","RefSeq","NP_848861.1","29053970","Study validates that SLC38A9 is an arginine sensor for the mTORC1 pathway, and we uncover an unexpectedly central role for SLC38A9 in amino acid homeostasis. SLC38A9 mediates the transport, in an arginine-regulated fashion, of many essential amino acids out of lysosomes, including leucine, which mTORC1 senses through the cytosolic Sestrin proteins."
> "Q8BGD6-1","RefSeq","NP_848861.1","28235079","After high-fat diet, Slc38a9 was specifically upregulated in hypothalamus, while overall downregulation was noticed throughout the brain. Publication Status: Online-Only"
3544a4802,4813
> "Q91ZZ3-1","RefSeq","NP_291088.1","29976232","The expression patterns of neuronal maturation markers in the brain of a mouse model of dementia with Lewy body-linked mutant beta-synuclein (betaS), especially in the hippocampus. Publication Status: Online-Only"
> "Q91ZZ3-1","RefSeq","NP_291088.1","30106256","P123H betaS Tg mice exhibited hyperlocomotor activity in a novel environment, a decrease in mobility time in the tail suspension test, and impairments in nest building."
> "Q91ZZ3-1","RefSeq","NP_291088.1","28052246","These results suggest that synucleins are important orchestrators of presynaptic terminal topography."
> "Q91ZZ3-1","RefSeq","NP_291088.1","12212795","Beta-synuclein decreased formation of Lewy bodies by 40%, and prevented functional deficits associated with overexpression of alpha-synuclein. This is a preliminary in vivo proof of antiaggregatory function of beta-synuclein."
> "Q91ZT5-1","RefSeq","NP_631978.1","25356636","The enrichment of activated Cdc42 in SSeCKS-null leading edge filopodia correlated with recruitment of the Cdc42-specific guanine nucleotide exchange factor, Frabin. Publication Status: Online-Only"
> "Q91ZT5-1","RefSeq","NP_631978.1","23171661","This study demonistrated that the disease-initiating event in CMT4H is loss of a Schwann cell-specific cellular function of Frabin/Fgd4."
> "E9PYH6-1","RefSeq","NP_821172.2","30008322","SET1A-mediated mono-methylation at K342 is an essential regulatory mechanism for regulating YAP activity and tumorigenesis."
> "E9PYH6-1","RefSeq","NP_821172.2","29968706","Study report that Uhrf1 forms a complex with the active trithorax group, the Setd1a/COMPASS complex, to maintain bivalent histone marks, particularly those associated with neuroectoderm and mesoderm specification. Publication Status: Online-Only"
> "E9PYH6-1","RefSeq","NP_821172.2","29348130","The comprehensive regulation of DNA damage responses by SETD1A in HSCs is clearly distinct from the key roles played by other epigenetic regulators, including the major leukemogenic H3K4 methyltransferase MLL1, or MLL5, indicating that HSC identity and function is supported by cooperative specificities within an epigenetic framework."
> "E9PYH6-1","RefSeq","NP_821172.2","16476528","MNSC1 lacks protein-coding capacity"
> "P97434-1","RefSeq","NP_957697.1","16243315","P116Rip oligomerizes via its C-terminal coiled-coil domain and, when overexpressed, inhibits RhoA-induced SRF activation without affecting RhoA-GTP levels."
> "P97434-1","RefSeq","NP_957697.1","12732640","P116Rip is an F-actin-binding protein with in vitro bundling activity and in vivo capability of disassembling the actomyosin-based cytoskeleton."
3560a4830,4836
> "P56485-1","RefSeq","NP_031748.2","30958662","CXCL14 is expressed by islet delta-cells where it may have paracrine effects to inhibit insulin secretion in a CXCR4/CXCR7-independent manner through reductions in beta-cell ATP levels."
> "P56485-1","RefSeq","NP_031748.2","29980568","CXCR7 serves as Dkk3 receptor, which mediates Dkk3-induced vascular progenitor migration in vitro and in tissue-engineered vessels."
> "P56485-1","RefSeq","NP_031748.2","29587613","Study shows that overexpression of CXCR7 in different cellular populations of endometriosis microenvironment may play a role in the pathogenesis and represent a novel target for treatment."
> "P56485-1","RefSeq","NP_031748.2","18442043","Seems to play an unimportant role in bone; however, an important role is indicated for CXCR7 in the cardiovascular system during embryonic and early postnatal development."
> "P56485-1","RefSeq","NP_031748.2","17804806","Disfrupted cardiac development but normal hematopoiesis in mice deficient in Cxcr7."
> "Q61464-1","RefSeq","NP_032743.2","25024404","ZNF638 participates in splicing decisions and that it may control adipogenesis through regulation of the relative amounts of differentiation-specific isoforms."
> "Q61464-1","RefSeq","NP_032743.2","21602272","ZNF638 is a novel and early regulator of adipogenesis that works as a transcription cofactor of C/EBPs."
3584a4861,4864
> "Q9QUK4-1","RefSeq","NP_035002.2","27114610","These results provide definitive genetic evidence for the important physiological function of NAIPs in antibacterial defense and inflammatory damage-induced lethality in mice."
> "Q9QUK4-1","RefSeq","NP_035002.2","27045008","Naip1 is uniquely required to detect T3SS needle protein and Naip2 is uniquely required to detect T3SS inner rod protein, but neither Naip1 nor Naip2 is required for detection of flagellin."
> "Q9QUK4-1","RefSeq","NP_035002.2","24516390","Activation of caspase-1 by Shigella is triggered by the rod protein MxiI that interacts with Naip2 to induce activation of the Nlrc4 inflammasome independently of the Pkcdelta kinase Publication Status: Online-Only"
> "Q6ZWY8-1","RefSeq","NP_079560.1","24623079","Tbeta10 has multiple functions in the developmental course from initiation to root formation of the tooth germ"
3586a4867
> "P33534-1","RefSeq","NP_035141.1","29863085","Our results indicate that the stimulation of kappa-opioid receptors in the hippocampus may ameliorate cognitive dysfunction through the activation of the cholinergic system. These findings may offer a therapeutic alternative approach in the treatment of depression patients' symptoms"
3595,3602c4876,4878
< "P97819-1","RefSeq","NP_001185952.1","30088174","PLA2G6 mutation causes degeneration of substantia nigra dopaminergic neurons by causing mitochondrial dysfunction, elevated endoplasmic reticulum stress, mitophagy impairment, and transcriptional abnormality."
< "P97819-1","RefSeq","NP_001185952.1","28655161","Two members of dynamical network biomarke, PLA2G6 and CYP2C44 were found to induce dysfunction of arachidonic acid metabolism and finally lead to impairments of liver detoxification and malignant transition to cancer."
< "P97819-1","RefSeq","NP_001185952.1","27789386","The antinociceptive effect of maprotiline was abrogated by iPLA2 antisense oligonucleotide injection to the prefrontal cortex, indicating a role of this enzyme in antinociception. In contrast, injection of iPLA2 antisense oligonucleotide to the somatosensory cortex did not reduce the antinociceptive effect of maprotiline."
< "P97819-1","RefSeq","NP_001185952.1","15024020","IPLA(2)beta and iPLA(2)gamma are required for the adipogenic program that drives resting 3T3-L1 cells into adipocytes after hormone stimulation"
< "P97819-1","RefSeq","NP_001185952.1","12167650","These findings support an RNA-dependent protein kinase-independent signaling role for iPLA(2) in the antiviral response of macrophages and the stimulation of inducible nitric oxide synthase expression."
< "Q8R5L3-1","RefSeq","NP_671495.1","20961651","Our data indicate that TRAP1 and VPS39 are nonredundant and essentially required for early embryonic development"
< "Q8R5L3-1","RefSeq","NP_671495.1","20363736","Although only TBC1D15/Rab7-GAP altered Rab7-GTP levels, both Rab7-GAP and mVps39 regulate lysosomal morphology and play a role in maintaining growth factor dependence"
< "Q8R5L3-1","RefSeq","NP_671495.1","15110766","Antibodies to VAMP and SNAP inhibited sperm-zona pellucida interaction, suggesting their possible involvement in sperm membrane vesiculation."
---
> "Q148R4-1","RefSeq","NP_001074649.1","20703245","Spink5/Par2 double knockout (DKO) mice, at embryonic day 19.5, display a dramatic decrease in TSLP expression, although stratum corneum detachment persists, confirming the role of the KLK5-PAR2 cascade in TSLP-mediated early proallergic signaling"
> "Q148R4-1","RefSeq","NP_001074649.1","15780751","Mouse Spink5/Lekti, like its human counterpart, is involved in the control of epithelial tissue homeostasis."
> "Q148R4-1","RefSeq","NP_001074649.1","15619623","Key regulator of epidermal protease activity"
3609a4886,4888
> "P83503-1","RefSeq","NP_775591.1","14507859","Human and mouse nyctalopin are membrane-bound extracellular proteins and are functionally conserved."
> "P83503-1","RefSeq","NP_775591.1","12714669","These data suggest an important function of the Nyx protein in the inner retina and provide evidence that CSNB1 is based on a defect in the inner retinal circuitry."
> "P83503-1","RefSeq","NP_775591.1","12506099","The nob phenotype is caused by an 85-bp deletion in the mouse nyx gene, which encodes the nyctalopin protein."
3613c4892,4896
< "Q02780-1","RefSeq","NP_001116424.1","30290178","It identified NFIA and ATF3 as drivers of astrocyte differentiation from neural precursor cells while RUNX2 promotes astrocyte maturation."
---
> "Q66JX5-1","RefSeq","NP_957682.1","29982567","We show that Fop mutation perturbs ciliogenesis in vivo and that this leads to the alteration of the Hedgehog signaling pathway. Fop mutation reduces CSs movements and affects pericentriolar material composition, which probably participates to the ciliogenesis defect."
> "Q66JX5-1","RefSeq","NP_957682.1","12969958","Expression of FOP-FGFR1 in primary bone marrow cells induced by retroviral transduction generates a myeloproliferative disease in mice"
> "D3Z3N4-1","RefSeq","NP_001073293.1","28100513","Effects were accompanied by paracrine and autocrine neuroglial deregulation of hnRNPH3 proteostasis in sciatic nerve and motoneurons, respectively, and post-transcriptional downregulation of metalloproteinase 28 in the sciatic nerve"
> "Q8R4V2-1","RefSeq","NP_665687.1","27891578","Dusp15 is necessary for full activation of Erk 1/2 phosphorylation in Schwann cells."
> "Q8R4V2-1","RefSeq","NP_665687.1","15138252","VHY is a new member of a subgroup of myristoylated VH1-like small dual specificity phosphatases"
3633a4917
> "Q7TM99-1","RefSeq","NP_080083.2","20022372","In situ hybridization survey of MCT subtypes in placenta detected intense mRNA expression of MCT1, MCT4, & MCT9 (gestational day 11.5 through day 18.5)."
3640a4925,4927
> "Q923X4-1","RefSeq","NP_075994.2","29274570","Ur results demonstrate that the GRX2-mediated regulation of O2(*-)/H2O2 release through the S-glutathionylation of mitochondrial proteins may play an integral role in controlling cellular ROS signaling"
> "Q923X4-1","RefSeq","NP_075994.2","29101900","Grx2 absence impairs mitochondrial fusion, ultrastructure and energetics in primary cardiomyocytes and cardiac tissue."
> "Q923X4-1","RefSeq","NP_075994.2","28618115","Study shows that Grx2 detoxifies *NO in mature oligodendrocytes and oligodendroglial precursor cellsvia the formation of dinitrosyl-iron-complexes, inhibiting the formation of harmful peroxynitrite and reducing subsequent oligodendroglial damage. Findings link inorganic biochemistry to neuroinflammation and identify glutaredoxin 2 as a protective factor against neuroinflammation-mediated myelin damage."
3655a4943,4951
> "Q3U2K5-1","RefSeq","NP_775609.2","30472235","JMJD2D interacts with b-catenin to activate transcription of its target genes and promote CRC cell proliferation, migration, and invasion, as well as formation of colorectal tumors in mice."
> "Q3U2K5-1","RefSeq","NP_775609.2","29800554","To determine the epigenetic mechanisms limiting CM cycling in adult cardiac myocytes (CMs) (ACMs) and whether trimethylation of lysine 9 of histone H3 (H3K9me3), a histone modification associated with repressed chromatin, is required for the silencing of cell cycle genes, we developed a transgenic mouse model where H3K9me3 is specifically removed in CMs by overexpression of histone demethylase, KDM4D"
> "Q3U2K5-1","RefSeq","NP_775609.2","21293030","These results suggest that demethylation of H3K9 in round spermatids is dispensable for spermatogenesis but that possible defects in Kdm4d-null elongating spermatids could be rescued by functional redundancy of the KDM4B demethylase."
> "Q9EQF6-1","RefSeq","NP_075534.1","28864883","Data show that SRY-box containing gene 5 protein (Sox5) can physically bind to the collapsin response mediator protein 5 (CRMP5) promoter DNA."
> "Q9EQF6-1","RefSeq","NP_075534.1","24324268","Study elucidates a novel regulatory mechanism that utilizes CRMP5-induced mitophagy to orchestrate proper dendrite outgrowth and neuronal function."
> "Q9EQF6-1","RefSeq","NP_075534.1","22437341","CRMP5-deficient mice show abnormal Schwann process extension resulting in abnormal cell-axon segregation, indicating that CRMP5 is involved in the morphologic adaptation of Schwann cells to surround axons."
> "Q9EQF6-1","RefSeq","NP_075534.1","15834957","Beyond their signalling function in axon outgrowth and guidance, CRMPs also play a role in mature neurons both in axons and in dendrites"
> "Q9EQF6-1","RefSeq","NP_075534.1","15926912","In the olfactory bulb, CRMP1, CRMP2 and CRMP5 are abundant in neuronal progenitors of the subependymal layer and in differentiating interneurons."
> "Q9EQF6-1","RefSeq","NP_075534.1","15509652","CRAM regulates filopodial dynamics and growth cone development, thereby restricting the response of growth cone to repulsive guidance cues"
3667a4964,4968
> "Q69ZU8-1","RefSeq","NP_536719.2","25218921","Results indicated that mAnkrd6 is a functional homolog of the Drosophila diego gene for mammalian planar cell polarity (PCP) regulation."
> "Q69ZU8-1","RefSeq","NP_536719.2","20827749","Results indicate that Diversin plays an important role in the proliferation of neuroblasts in the subventricular zone of the adult brain."
> "Q69ZU8-1","RefSeq","NP_536719.2","19789178","These observations suggest that the centrosomal localization of Diversin is crucial for its function in Wnt signaling."
> "Q69ZU8-1","RefSeq","NP_536719.2","12203740","These data suggest that ankyrin repeat domain 6 (Ankrd6) may be involved in brain development in interaction not only with Celsr/Flamingo but also with other signaling pathways."
> "Q99MU1-1","RefSeq","NP_036036.2","18459117","The functional plasma membrane transport of TPRA40 that regulates cell division of mouse embryos is mediated by NA14."
3670,3673d4970
< "Q8BYH8-1","RefSeq","NP_001297459.1","29665362","A loosened chromatin structure, which is mediated by Chd9, is a prerequisite for the acquisition of totipotency after fertilization."
< "Q8BYH8-1","RefSeq","NP_001297459.1","25689118","Our new findings support the role for CHD9 in chromatin regulation and association with rDNA genes, in addition to its already known function in transcription control of tissue specific genes"
< "Q8BYH8-1","RefSeq","NP_001297459.1","16523501","CReMM is a chromodomain helicase-DNA-binding protein expressed by osteoprogenitors[CReMM]"
< "Q8BYH8-1","RefSeq","NP_001297459.1","16419031","Results imply that in osteogenic cells CReMM/CHD9 selectively interacts with promoters activated in the tissue at the appropriate time of embryonic development."
3689a4987,4990
> "Q8CGN4-1","RefSeq","NP_778211.2","30902969","This study provides mechanistic understanding of how BCOR regulates cell fate decisions and how loss of function contributes to the development of leukaemia. Publication Status: Online-Only"
> "Q8CGN4-1","RefSeq","NP_778211.2","30228234","Results reveal a tumor suppressor function of BCOR in myeloid malignancies and highlight the impact of Bcor insufficiency on the initiation and progression of MDS."
> "Q8CGN4-1","RefSeq","NP_778211.2","28827447","Results provide the first evidence of a tumor suppressor role for BCOR in the pathogenesis of T lymphocyte malignancies"
> "Q8CGN4-1","RefSeq","NP_778211.2","28262675","Genomic characterization of Emu-Myc mouse lymphomas identifies Bcor as a Myc cooperative tumor-suppressor gene. Publication Status: Online-Only"
3692a4994,5004
> "Q99LD8-1","RefSeq","NP_001177378.1","30569164","The overexpression of DDAH2 attenuates myocardial fibrosis and protects against Diabetic cardiomyopathy DCM through activation of the DDAH/ADMA/NOS/NO pathway"
> "Q99LD8-1","RefSeq","NP_001177378.1","27838434","We conclude that pp60(Src) can directly inhibit DDAH II and this is involved in the increased ADMA levels that enhance eNOS uncoupling during the development of acute lung injury (ALI)."
> "Q99LD8-1","RefSeq","NP_001177378.1","26516203","In mild CKD, dysregulation of the ADMA/DDAH pathway in adipose tissue triggers lipodystrophy-like phenotype changes, including ectopic fat depositions."
> "Q99LD8-1","RefSeq","NP_001177378.1","23430976","The Sirt1/DDAH2/secretagogin pathway is a novel regulator of glucose-stimulated insulin secretion."
> "Q99LD8-1","RefSeq","NP_001177378.1","18567702","Report tissue-specific downregulation of DDAH2 in hyperhomocysteinemia."
> "Q99LD8-1","RefSeq","NP_001177378.1","17601800","DDAH2/ADMA pathway can be a novel therapeutic target for vasculopathy in the ADMA or angiotensin II-induced pathophysiological conditions"
> "Q91ZZ5-1","RefSeq","NP_536716.2","27579888","Loss of function of Lgr6 did not impact epidermal cell proliferation, cell migration and wound healing."
> "Q91ZZ5-1","RefSeq","NP_536716.2","26855023","Results suggest that DES causes testicular maldescent by altering the LGR8 pathway in mouse gubernaculum testis cells. Publication Status: Online-Only"
> "Q91ZZ5-1","RefSeq","NP_536716.2","26823808","The results displayed that INSL3 changed RXFP2 expression in mouse gubernaculum testis cells in vitro Publication Status: Online-Only"
> "Q91ZZ5-1","RefSeq","NP_536716.2","14666470","Disruption of the Greatgene causes failure of the transabdominal phase of descent, identical to that seen in the Insl3-deficient mutants, consistent with the recent data suggesting that Great gene encodes the Insl3 transmembrane receptor."
> "Q91ZZ5-1","RefSeq","NP_536716.2","12933905","Insulin-like 3 peptide or great cause cryptorchidism (undescended testes) in mice."
3699a5012,5014
> "Q8VHQ3-1","RefSeq","NP_694729.1","27709267","TIMAP is suppressed by TGFbeta via HDAC3-associated Smad signaling."
> "Q8VHQ3-1","RefSeq","NP_694729.1","21907835","These data confirmed the barrier-protective role of TIMAP"
> "Q8VHQ3-1","RefSeq","NP_694729.1","12638124","MRNA is located in cell bodies and dendrites of neurons in four distinct regions of the brain."
3704a5020,5033
> "P08607-1","RefSeq","NP_031602.3","28542817","Data suggest that C4bp prevents interaction between Tlr4/MD-2 and its ligand; C4bp does not appear to interact with Tlr3; C4bp binds to macrophage surface Tlr4 and inhibits Tlr/Tlr ligand interaction, thereby inhibiting Tlr4 activation. (C4bp = complement component 4 binding protein; Tlr = toll-like receptor; MD-2 = myeloid differentiation protein-2)"
> "P08607-1","RefSeq","NP_031602.3","27794068","This study shows that C4BP binds to TLR2, inhibits TLR1/2 ligand binding and reduces cytokine production"
> "P08607-1","RefSeq","NP_031602.3","25468721","These results suggest that EpC4BP is involved in male reproduction, but not essential for sperm maturation."
> "P08607-1","RefSeq","NP_031602.3","18266273","The cellular uptake of C4BP depends on both heparan sulfate proteoglycans and CD91, involving interactions with positively charged residues within C4BP alpha-chain."
> "P42227-1","RefSeq","NP_998825.1","31177110","Study provides evidence that Stat3 activity is required for HC11 mammary epithelial cell differentiation."
> "P42227-1","RefSeq","NP_998825.1","31036001","Studied effect of Papaver nudicaule extract on reduction of inflammation through inactivating NF-kappaB and signal transducer and activator of transcription 3 (STAT3) in lipopolysaccharide treated RAW264.7 cells. Publication Status: Online-Only"
> "P42227-1","RefSeq","NP_998825.1","30996264","Study identified Fam3a, a cytokine-like protein, as a major Stat3 downstream effector in muscle stem cells and demonstrated that Fam3a is required for muscle stem cell commitment and skeletal muscle development. These findings indicate that Fam3a is a Stat3-regulated secreted factor that promotes muscle stem cell oxidative metabolism and differentiation. Publication Status: Online-Only"
> "P42227-1","RefSeq","NP_998825.1","31026806","Model suggests a negative role for STAT3 in regulating class switching of the GC B cells from the IgG1 to the IgE producing state. Publication Status: Online-Only"
> "Q9ET35-1","RefSeq","NP_067324.1","30473702","TACI -/- mice are able to clear the infection and resist rechallenge infection. Publication Status: Online-Only"
> "Q9ET35-1","RefSeq","NP_067324.1","29871859","Data (including data from studies in knockout mice and cells from such mice) suggest that Taci in peritoneal and adipose tissue macrophages is involved in regulation of adipogenesis leading to obesity."
> "Q9ESE1-1","RefSeq","NP_109620.2","28893864","LRBA deficiency is associated with a reduced abundance of radixin and Nherf2, two adaptor proteins, which are important for the mechanical stability of the basal taper region of stereocilia."
> "Q9ESE1-1","RefSeq","NP_109620.2","28652580","Lrba-/- mice displayed decreased cytotoxic T-lymphocyte-associated protein-4 expression by regulatory T cells and activated conventional CD4+ and CD8+ T lymphocytes, reduced frequency of peritoneal B-1a cells along with diminished interleukin-10 production and increased percentages of T follicular helper cells in Peyer's patches, but without developing overt signs of autoimmunity"
> "Q9ESE1-1","RefSeq","NP_109620.2","28611475","These studies revealed that LRBA has a critical, cell-autonomous role in promoting cytotoxic T-lymphocyte antigen-4 accumulation within CD4 effector T cells and FOXP3+ T-regulatory cells"
> "Q9ESE1-1","RefSeq","NP_109620.2","28814779","LRBA role in olfaction.LRBA is expressed in olfactory and vomeronasal sensory neurons.LRBA is required for the efficient subcellular localization of a lipid-anchored protein, and of a ciliary protein. Publication Status: Online-Only"
3714a5044,5047
> "Q3U8K7-1","RefSeq","NP_659120.3","27920088","Suv4-20h1/h2 are mostly absent in mouse embryos before implantation, underscoring a rapid decrease of H4K20me3 from the two-cell stage onward"
> "Q3U8K7-1","RefSeq","NP_659120.3","26669898","Suv4-20h1, an H4K20 dimethyltransferase, controls Skeletal muscle stem cell quiescence by promoting formation of facultative heterochromatin."
> "Q3U8K7-1","RefSeq","NP_659120.3","23720823","This study suggests a novel role of FRG1 as epigenetic regulator of muscle differentiation and indicates that Suv4-20h1 has a gene-specific function in myogenesis."
> "Q3U8K7-1","RefSeq","NP_659120.3","17846168","There is a novel role for histone lysine methylation in controlling telomere recombination."
3731,3738d5063
< "P63058-1","RefSeq","NP_001300912.1","30292450","TRalpha seems to have an inhibitory impact on angiotensin (AGT) and AT1Ra expression, and loss of TRalpha function in TRalpha(0/0) mice increases tissue renin-angiotensin system expression in the aortic wall. More importantly, TRalpha deletion significantly increases vascular smooth muscle cells cholesterol content. Our results are consistent with a protective role of TRalpha against atherosclerosis."
< "P63058-1","RefSeq","NP_001300912.1","29753845","Data suggest that gestational/maternal endocrine disruptor DEHP [di-(2-ethylhexyl) phthalate] exposure dose-dependently causes fetal IUGR (intrauterine growth restriction); mRNA levels of placental Thra1 and Thrb1 are reduced and nuclear translocation of placental Thra1 and Thrb1 is suppressed in DEHP-exposed mice."
< "P63058-1","RefSeq","NP_001300912.1","29648626","Knockdown of the main TR in macrophages, TRalpha, impaired polarization into proinflammatory macrophages and amplified polarization into immunomodulatory macrophages."
< "P63058-1","RefSeq","NP_001300912.1","30092589","Thyroid hormone receptor alpha deletion in ApoE-/- mice slightly increases the expression of tissue renin-angiotensin system in the aorta and aggravates the dysregulation of cholesterol content in the vascular smooth muscle cells."
< "Q8VHX6-1","RefSeq","NP_001074654.1","26929074","HSPB7 is essential for maintaining muscle integrity, which is achieved through its interaction with FLNC"
< "Q8CHB8-1","RefSeq","NP_001074892.2","28173158","Mouse models carrying truncating mutations in TTLL5 gene display reduced fertility in male animals."
< "Q8CHB8-1","RefSeq","NP_001074892.2","27162334","Study uncovers the pathogenic mechanism whereby absence of RPGR(ORF15) glutamylation leads to retinal pathology in patients with TTLL5 gene mutations and connects these two genes into a common disease pathway."
< "Q8CHB8-1","RefSeq","NP_001074892.2","23558686","STAMP appears to participate in a unique, tissue-selective TTLL-mediated pathway for alpha-tubulin polyglutamylation that is required for sperm maturation and motility and may be relevant for male fertility."
3742a5068,5072
> "Q8BHN3-1","RefSeq","NP_032086.1","18648322","Progression of neuropathologic and Behavioral abnormalities in a Pompe disease mouse model (6neo/6neo) that displays many features of the human disease"
> "Q61823-1","RefSeq","NP_035180.2","30841417","MALAT1-miR-200a-3p-PDCD4 axis regulated the proliferation."
> "Q61823-1","RefSeq","NP_035180.2","30760284","We identify PDCD4 as an important ubiquitination substrate of SKP2 Publication Status: Online-Only"
> "Q61823-1","RefSeq","NP_035180.2","30257106","IcroRNA-21 mediates high Pi-induced endothelial cell apoptosis, which involves an ERK1/2/microRNA-21/PDCD4 pathway. High Pi-induced downregulation of NF-kappaB expression is mediated by an ERK1/2 signaling-dependent but microRNA-21-independent mechanism"
> "Q61823-1","RefSeq","NP_035180.2","29923218","Results found that PDCD4, a validated target of miR-21, was highly expressed in both injured kidney tissues and LPS-stimulated TKPTS cells. Meanwhile, the protein expression of PDCD4 was significantly reduced by inhibition of MEG3, but retrieved by co-inhibition of MEG3 and miR-21."
3763a5094,5100
> "Q8C0Y1-1","RefSeq","NP_775572.1","30808659","Tgifs play an important role in regulating basic energy metabolism in normal cells, and that this function of Tgifs is amplified in some cancers."
> "Q8C0Y1-1","RefSeq","NP_775572.1","27956704","Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect. Publication Status: Online-Only"
> "Q8C0Y1-1","RefSeq","NP_775572.1","28193997","Studies indicate the reprogramming activity of TG-interacting factor 2 (TGIF2) and suggest a stepwise reprogramming paradigm. Publication Status: Online-Only"
> "Q8C0Y1-1","RefSeq","NP_775572.1","16436215","The Tgif2 gene contains a retained intron, within the second coding exon. One splice variant encodes the full length 237 amino acid Tgif2, whereas the shorter form results in the removal of 39 codons from the centre of the coding region. Publication Status: Online-Only"
> "Q8C0Y1-1","RefSeq","NP_775572.1","15749073","TGIF2 has a wide but well controlled expression pattern during mouse development."
> "Q64092-1","RefSeq","NP_766060.2","30520728","Expression of multiple genes implicated in cell cycle control is altered in TFEB/TFE3 DKOs, revealing a previously unrecognized role of TFEB and TFE3 in the regulation of cell cycle checkpoints in response to stress. Publication Status: Online-Only"
> "Q64092-1","RefSeq","NP_766060.2","28483914","Tfe3 and Tfeb are required for the induced expression of Ppargamma2 and subsequently for adipogenic genes. Erratum:[Mol Cell Biol. 2017 Oct 13;37(21):. PMID: 29030472] Publication Status: Online-Only"
3771,3773c5108,5112
< "Q8C863-1","RefSeq","NP_001230641.1","29925997","Itch and WWP2 cooperate to regulate TH2 differentiation by enhancing the strength of the TCR signal via inducing atypical ubiquitination of the phosphatase SHP-1."
< "Q8C863-1","RefSeq","NP_001230641.1","29515120","Beta-Arrestin2 increases the Itch-mediated ubiquitylation of SuFu. Publication Status: Online-Only"
< "Q8C863-1","RefSeq","NP_001230641.1","28747490","Findings show that the WW domains proceeding the catalytic HECT domain play an inhibitory role by binding directly to HECT in Itch; study provides a new mechanism governing the regulation of Itch"
---
> "Q62394-1","RefSeq","NP_033575.3","28627666","ZNF185 was highly expressed in Leydig cells of the testis and involved in the secretion of testosterone and the knockdown of ZNF185 expression did not significantly affect cell cycle progression or apoptosis."
> "Q62394-1","RefSeq","NP_033575.3","20937232","ZNF185 is the most abundant in the testes and is located in Leydig cells and sperm. Leydig cells has weak expression and in round spermatids and mature sperm it is highly expressed."
> "Q62394-1","RefSeq","NP_033575.3","18239999","These data offered evidence for the association of mouse Zfp185 with F-actin, which supports the potential role of Zfp185 in cell fundamental activity."
> "Q8K5B2-1","RefSeq","NP_789778.1","29735583","MCFD2-deficient mice generated by gene targeting also demonstrate reduced plasma FV and FVIII, with levels lower than those in LMAN1-deficient mice, similar to previous observations in LMAN1- and MCDF2-deficient humans."
> "Q8K5B2-1","RefSeq","NP_789778.1","16899390","These results indicate that increased levels of cargo receptor proteins might have a function either in the quality control of protein folding in the endoplasmic reticulum or in the homeostasis of the intermediate compartment and Golgi complex."
3775,3777c5114,5115
< "Q6PCM1-1","RefSeq","NP_001033784.2","29674659","JMJD1A mediates two major signaling pathways, namely, beta-adrenergic receptor and peroxisome proliferator-activated receptor-gamma (PPARgamma) activation, via PRDM16-PPARgamma-P-JMJD1A complex for beige adipogenesis. Publication Status: Online-Only"
< "Q6PCM1-1","RefSeq","NP_001033784.2","29526734","JMJD1A and JMJD1B, in combination, ensure early embryogenesis and embryonic stem cell viability by establishing the correct Histone 3 lysine 9 methylated epigenome."
< "Q6PCM1-1","RefSeq","NP_001033784.2","16619273","TSGA may modulate the function of ER71 and thereby affect spermatogenesis as well as embryonic development"
---
> "P68404-1","RefSeq","NP_032881.1","30889825","Phorbol 12-myristate 13-acetate induced PRKCB, improved lipopolysaccharide-tolerance, and attenuated sepsis severity, predominantly in FcGRIIb-/- mice. Publication Status: Online-Only"
> "P68404-1","RefSeq","NP_032881.1","29744369","Our results suggest that the decrease in the activity of cPKCbetaII and cPKCgamma, especially cPKCgamma, may play key roles in the pathogenesis of diabetic encephalopathy. Publication Status: Online-Only"
3792,3798d5129
< "Q8BX10-1","RefSeq","NP_001157010.1","29770487","Melatonin treatment inhibited the Ripk3-PGAM5-CypD-mPTP cascade and thus reduced cellular necroptosis, conferring a protective advantage to the endothelial system in IR stress."
< "Q8BX10-1","RefSeq","NP_001157010.1","29524517","Findings suggest that HO-1 protects against I/R-induced hepatic injury via regulation of mitochondrial QC by PGAM5 signaling."
< "Q8BX10-1","RefSeq","NP_001157010.1","29438981","Damaged mitochondria may induce replenishment of the mitochondrial pool by cell-intrinsic activation of Wnt signaling via the Pgam5-beta-catenin axis."
< "Q8BX10-1","RefSeq","NP_001157010.1","26381214","Results identify a crucial role for RIPK3-PGAM5-Drp1/NFAT signalling in NKT cell activation, and further suggest that RIPK3-PGAM5 signalling may mediate crosstalk between mitochondrial function and immune signalling. Publication Status: Online-Only"
< "Q8BX10-1","RefSeq","NP_001157010.1","25222142","Loss of PGAM5 disables PINK1-mediated mitophagy in vitro and leads to dopaminergic neurodegeneration and mild dopamine loss in vivo causing a Parkinson's-like movement disorder. Publication Status: Online-Only"
< "Q8BX10-1","RefSeq","NP_001157010.1","25012655","Data indicate that phosphoglycerate mutase 5 (PGAM5) contains an N-terminal WDXNWD motif required for multimerization and maximal phosphatase activity."
< "Q8BX10-1","RefSeq","NP_001157010.1","22265414","Experimental data indicate that the two splice variants of the mitochondrial protein phosphatase PGAM5 are at the convergent point of multiple necrosis pathways."
3800,3801d5130
< "Q5DTM8-1","RefSeq","NP_001156735.1","28453857","The results demonstrate that Fbxl19 recruitment to CpG islands is required for Rnf20-mediated H2B monoubiquitination."
< "Q5DTM8-1","RefSeq","NP_001156735.1","20738173","The observed defects in the radiation response of Bre1a/b-deficient cells"
3805a5135
> "Q45VN2-1","RefSeq","NP_899091.2","19106102","The most distal N-terminal anionic residues of pro-Crp4-(20-92) are primarily responsible for blocking Crp4-mediated membrane disruption in the precursor."
3809,3810d5138
< "Q8K1E0-1","RefSeq","NP_001161271.1","28000760","Stx5 is an autophagy target that is inefficiently membrane-targeted by alternative pathways; mice without WRB have different biogenesis requirements for tail anchored proteins Publication Status: Online-Only"
< "Q8K1E0-1","RefSeq","NP_001161271.1","18836075","Pkd2 in the ER plays a role in cellular Ca(2+) homeostasis and Stx5 functions to inactivate Pkd2 and prevent leaking of Ca(2+) from ER stores"
3824a5153,5155
> "Q8BG54-1","RefSeq","NP_780676.1","25607821","Hepatic expression of Sptlc3 mRNA may be closely associated with NASH-associated hepatocarcinogenesis."
> "Q99KW3-3","RefSeq","NP_613045.3","28209736","Missense mutations in the Pejvakin (PJVK or DFNB59) gene were first identified in patients with audiological hallmarks of auditory neuropathy spectrum disorder, whereas all other PJVK alleles cause hearing loss of cochlear origin. These findings suggest that complex pathogenetic mechanisms underlie human deafness DFNB59."
> "Q99KW3-3","RefSeq","NP_613045.3","23789641","R1 motif is the major actin-binding domain of TRIOBP-4, and the binding of R2 motif with actin filaments is nonspecific."
3831a5163
> "Q3UWA4-1","RefSeq","NP_001028407.1","29117565","TRIM40 binds to MDA5 and RIG-I and promotes their K27- and K48-linked polyubiquitination via its E3 ligase activity, leading to their proteasomal degradation. TRIM40 deficiency enhances RLR-triggered signaling."
3850a5183,5187
> "O35903-1","RefSeq","NP_033164.1","29154408","These results showed a site- and cell-specific expressions of Ccl25 and its receptor Ccr9 within both maternal and embryonic compartments of implantation sites and suggested a role in inducing specific Ccr9+ leukocytes at the maternal-fetal interface during the initial steps of embryo implantation in the mouse model"
> "O35903-1","RefSeq","NP_033164.1","27646003","MicroRNA-205 maintains T cell development following stress by regulating Foxn1 and its two regulated targets, stem cell factor and ccl25, following stress."
> "O35903-1","RefSeq","NP_033164.1","26921718","TECK was shown to be expressed by osteoblasts, and its receptor, CCR9, by osteoclast precursors. TECK increased P. gingivalis LPS-induced osteoclast numbers in an in vitro osteoclast formation assay using osteoclast precursors. T"
> "O35903-1","RefSeq","NP_033164.1","27795621","CCR9 and CCL25 expressions are induced in the early stages of airway inflammation and they have an important role modulating eosinophils and lymphocytes recruitment at the first stages of inflammatory process"
> "O35903-1","RefSeq","NP_033164.1","11981810","Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR.  (CCX-CKR)"
3861a5199,5204
> "A2AQ92-1","RefSeq","NP_001092767.1","28982074","Reactive Oxygen Species levels were elevated and DUOX1 expression was increased 70-fold in OVA-allergen challenged lungs."
> "A2AQ92-1","RefSeq","NP_001092767.1","28337995","Cigarette smoke impairs A2A adenosine receptor mediated wound repair through up-regulation of Duox-1 expression. Publication Status: Online-Only"
> "A2AQ92-1","RefSeq","NP_001092767.1","27650496","Redox-dependent regulation of EGFR activation in airway epithelial cells was found to strongly depend on activation of either DUOX1 or NOX2."
> "A2AQ92-1","RefSeq","NP_001092767.1","27599561","Data, including data from studies using transgenic mice, suggest that over-expression of IL4 (interleukin 4) in thyroid tissue/cells up-regulates expression of Duox1 (dual oxidase 1), Duoxa1 (dual oxidase maturation factor 1), and Slc26a4 (pendrin) in thyroid tissue/cells; expression of Slc5a5 (sodium-iodide symporter) is down-regulated."
> "A2AQ92-1","RefSeq","NP_001092767.1","26597162","Our findings implicate epithelial DUOX1 as a pivotal mediator of IL-33-dependent activation of innate airway type 2 immune responses to common airborne allergens and indicate that enhanced DUOX1 expression and IL-33 secretion might present important contributing features of allergic asthma."
> "A2AQ92-1","RefSeq","NP_001092767.1","17643428","Duox1 is the main source of H(2)O(2) in the rat thyroid cell line PCCl3."
3863a5207,5211
> "Q8BWL5-1","RefSeq","NP_848775.2","22372950","Binding of Rbms3 to the 3'UTR of Ptf1a regulates the production of the Ptf1a protein"
> "Q9QXA6-1","RefSeq","NP_067266.1","17596531","A new protocol with d-penicillamine to validate our Slc7a9 knockout mouse model for the study of the therapeutic effect of drugs in the treatment of cystine lithiasis is reported."
> "Q9QXA6-1","RefSeq","NP_067266.1","15044460","Mouse amino acid transport system B0 is a neutral amino acid transporter related to Hartnup disorder"
> "Q9QXA6-1","RefSeq","NP_067266.1","12915471","Slc7a9-deficient mice develop cystinuria non-I and cystine urolithiasis"
> "Q9QXA6-1","RefSeq","NP_067266.1","12167606","A decreasing expression gradient of heterodimeric rBAT-b(0,+)AT along the proximal tubule is responsible for virtually all apical cystine reabsorption"
3871a5220,5222
> "Q9QYE6-1","RefSeq","NP_038775.1","28509431","Golga5 is not required for mouse embryonic development, postnatal survival, or fertility."
> "Q9QYE6-1","RefSeq","NP_038775.1","24368089","Its deficit is associated with Golgi fragmentation that induces tau hyperphosphorylation."
> "Q8BVD7-1","RefSeq","NP_780634.2","28223291","In obese male mice consuming a high-fat diet, CTRP7 deficiency attenuated insulin resistance and enhanced glucose tolerance, independent of body weight, metabolic rate, and physical activity level. Improved glucose metabolism in CTRP7-deficient mice was associated with reduced adipose tissue inflammation, as well as decreased liver fibrosis and cellular oxidative and endoplasmic reticulum stress."
3873a5225,5230
> "Q3UL53-1","RefSeq","NP_001192203.1","25817697","Expression of EGAM1N could inhibit differentiation by elevating the protein levels of pluripotency factors in mouse ES cells."
> "Q3UL53-1","RefSeq","NP_001192203.1","23510645","Nuclear localization of exogenously expressed EGAM1 homeoproteins (EGAM1, EGAM1N, and EGAM1C) was determined.  The amino acid residues crucial for the nuclear translocation of EGAM1 and EGAM1C were identified."
> "Q3UL53-1","RefSeq","NP_001192203.1","22367590","Capable of affecting the stabilization of an undifferentiated state and the progression of differentiation in MG1.19 embryonic stem cells GeneRIF: the ectopic expression of EGAM1C is capable of affecting the stabilization of an undifferentiated state and the progression of differentiation in MG1.19 ES cells, in addition to affecting cellular morphology and growth."
> "Q3UL53-1","RefSeq","NP_001192203.1","21084569","EGAM1C may play a role in the expression of members of the placental PRL gene family, such as Prl3b1 and Prl5a1."
> "Q3UL53-1","RefSeq","NP_001192203.1","20018908","These transcripts encoding homeoproteins are capable of regulating the maintenance and/or differentiation of mouse ES cells and likely regulate that of preimplantation embryos."
> "Q3UL53-1","RefSeq","NP_001192203.1","19800316","This is the first delineation of the physiological role of CrxOS in ES cells."
3875,3878c5232,5235
< "Q9CPV0-1","RefSeq","NP_080114.1","28954202","Multiple roles in craniofacial development"
< "Q9CPV0-1","RefSeq","NP_080114.1","26518474","TMEM107 Is a critical regulator of ciliary protein composition and is mutated in orofaciodigital syndrome mice."
< "Q9CPV0-1","RefSeq","NP_080114.1","26595381","TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome"
< "Q9CPV0-1","RefSeq","NP_080114.1","22698544","Data show that Transmembrane protein 107 (Tmem107) is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types."
---
> "Q6ZWS4-1","RefSeq","NP_082684.1","26239289","Study's convergent findings in humans and mice support CNIH3 involvement in the pathophysiology of opioid dependence, complementing prior studies implicating the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate system"
> "Q6ZWS4-1","RefSeq","NP_082684.1","23522044","In cornichon-3 and cornichon-2 knockout mice there is a profound reduction of AMPA receptor synaptic transmission in the hippocampus."
> "Q9ES70-1","RefSeq","NP_067619.1","20595392","NEK6 is overexpressed in various human cancer tissues, and ectopic expression of NEK6 increases tumor promoter-induced transformation of JB6 Cl41 mouse epidermal cells."
> "Q9ES70-1","RefSeq","NP_067619.1","11744387","During early embryogenesis nek6 is highly expressed in primary giant trophoblast cells. Later in embryogenesis, nek6 is found in ventricular and sub-ventricular regions."
3880a5238,5241
> "Q6P9R2-1","RefSeq","NP_598746.2","30563844","Regulation of erythrocyte Na(+)/K(+)/2Cl(-) cotransport by an oxygen-switched kinase cascade."
> "Q6P9R2-1","RefSeq","NP_598746.2","19008908","Review: NCC in the distal convoluted tubule plays a critical role in NaCl and, indirectly, in K+ homeostasis; regulation by SPAK/OSR1 kinases and WNKs."
> "Q6P9R2-1","RefSeq","NP_598746.2","18800028","Phosphorylation states of NCC and OSR1/SPAK (Gene: Oxsr1, GeneID: 108737) were increased by low-salt diets and decreased by high-salt diets"
> "Q6P9R2-1","RefSeq","NP_598746.2","16382158","OSR1, a kinase closely related to SPAK, exhibited similar kinase properties and similar functional activation of NKCC1 when coexpressed with WNK4."
3897a5259,5261
> "O35718-1","RefSeq","NP_031733.1","30617600","It is a negative feedback inhibitor of cytokine signaling with T-cell-mediated immunosuppressive effects on obliterative bronchiolitis."
> "O35718-1","RefSeq","NP_031733.1","30487798","The results reveal that SOCS3 is involved in IL23-induced spondyloarthritis and acts as a key regulator of osteoblast differentiation, and suggest that SOCS3 knockdown TG mice may be an ideal animal model for further studies of spondyloarthritis. Publication Status: Online-Only"
> "O35718-1","RefSeq","NP_031733.1","30098334","MBD2-mediated Th17 differentiation in severe asthma is associated with impaired SOCS3 expression."
3898a5263,5266
> "Q08857-1","RefSeq","NP_031669.3","30290792","Normal and defective embryos lacking SR-B1 have divergent expression profiles Publication Status: Online-Only"
> "Q08857-1","RefSeq","NP_031669.3","30321786","Increased hepatic CD36 expression exaggerated nonalcoholic fatty liver disease."
> "Q08857-1","RefSeq","NP_031669.3","30294911","CD36 is important for nutrient homeostasis to maintain exercise performance of skeletal muscle."
> "Q08857-1","RefSeq","NP_031669.3","27145700","Coexpression of the Olfr287 in olfactory sensory neurons with CD36 suggests that only a specific set of olfactory receptors may be coexpressed with CD36 in these neurons. Publication Status: Online-Only"
3901a5270,5273
> "Q9JMK2-1","RefSeq","NP_038795.3","29784789","Studied roles of CK1delta and CK1e in regulation of PER2 in circadian rhythm."
> "Q9JMK2-1","RefSeq","NP_038795.3","29463694","CK1delta/epsilon disruption mouse had a long (27.4 h) behavioral period to which peripheral clocks entrained in vivo, albeit with an advanced phase ( approximately 6 h)."
> "Q9JMK2-1","RefSeq","NP_038795.3","28963394","Here, the authors identify another Wnt signaling amplifier, CKIepsilon, which is specifically upregulated in intestinal stem cells and is essential for intestinal stem cell maintenance, especially in the absence of its close isoform CKIdelta."
> "Q9JMK2-1","RefSeq","NP_038795.3","28594147","Csnk1e deletion increased mu opioid receptor-dependent behaviors. Erratum:[Genes Brain Behav. 2017 Nov;16(8):823. PMID: 29115739]"
3903a5276,5282
> "P58681-1","RefSeq","NP_573474.1","30630901","TLR7 and TLR9 specify monocyte fate and identify a specialized population of phagocytes responsible for anemia and thrombocytopenia associated with inflammation and infection."
> "P58681-1","RefSeq","NP_573474.1","30551443","Th17-associated cytokines through NF-kappaB and toll-like receptor 7 (TLR7) signaling."
> "P58681-1","RefSeq","NP_573474.1","30564235","The critical roles MMP10 plays in controlling macrophage activation to indicate that the development of immune tolerance to TLR7 ligand is dependent on this macrophage-derived proteinase. Publication Status: Online-Only"
> "P58681-1","RefSeq","NP_573474.1","30498494","A critical role of CD180 in regulating TLR7- and TLR9-mediated activation of macrophages and DCs. Publication Status: Online-Only"
> "P58681-1","RefSeq","NP_573474.1","14976262","Mediates species-specific recognition of GU-rich single-stranded RNA (ssRNA); data suggest that ssRNA represents a physiological ligand for TLR7"
> "P58681-1","RefSeq","NP_573474.1","14976261","Results identify ssRNA as a ligand for TLR7 and suggest that cells of the innate immune system sense endosomal ssRNA to detect infection by RNA viruses"
> "P58681-1","RefSeq","NP_573474.1","12875990","Results suggest novel signaling pathway in murine macrophages involving synergy between toll-like receptors 2, 4, 7, and 9 and adenosine A(2A)receptors, that up-regulates VEGF and down-regulates TNFalpha expression, thus acting as an angiogenic switch."
3915a5295,5299
> "O35714-1","RefSeq","NP_068820.1","30755607","Authors demonstrate that GITR engagement of activated, but not naive, ILC2s improves glucose homeostasis, resulting in both protection against insulin resistance onset and amelioration of established insulin- resistance. Publication Status: Online-Only"
> "O35714-1","RefSeq","NP_068820.1","29623077","A novel association of Group 1 innate lymphoid cell (ILC1) functionality and the expression of GITR was observed, which hints toward a so far undescribed role of GITR in regulating ILC1s responsiveness. Overexpression of GITR inhibits IFN-gamma production by ILC1s, whereas partial reduction of GITR expression can reverse this effect, thereby regulating ILC1 functionality. Publication Status: Online-Only"
> "O35714-1","RefSeq","NP_068820.1","28611044","Expression of human GITR was comparable with that of mouse GITR in tumor-infiltrating Tregs despite being drastically lower in other human TILs and in many human peripheral blood populations."
> "O35714-1","RefSeq","NP_068820.1","28649380","These findings support further study into combination partners for GITRL-FP that may augment CD8 T-cell priming as well as provide hypotheses that can be tested in human clinical trials exploring GITR agonists including GITRL-FP. Publication Status: Online-Only"
> "O35714-1","RefSeq","NP_068820.1","11869690","A functional role for this receptor in regulating the CD4+CD25+ T cell subset."
3919a5304,5311
> "Q8BPB5-1","RefSeq","NP_666127.2","28383766","TWEAK promotes migration and invasion in murine embryonic fibroblasts through a mechanism dependent on ERKs activation and Fibulin 3 down-regulation."
> "Q8BPB5-1","RefSeq","NP_666127.2","28622396","Mutant fibulin-3 causes proteoglycan accumulation, reduction of MMP-2 and MMP-9, but increase of TIMP-3, and impairs diffusion across Bruch's membrane."
> "Q8BPB5-1","RefSeq","NP_666127.2","17664227","The Efemp1 knock-in mice reconstitute the most important histopathologic symptoms of both Malattia leventinese and age-related macular degeneration."
> "Q80YE7-1","RefSeq","NP_598823.1","30120735","Activation of DAPK1 impairs learning and memory by degrading Caytaxin during aging."
> "Q80YE7-1","RefSeq","NP_598823.1","29317503","Promoting ER stress-ATF6-DAPK1 signaling in transporting enterocytes counters the transcellular passage of bacteria evoked by dysfunctional mitochondria"
> "Q80YE7-1","RefSeq","NP_598823.1","28731405","Excitotoxicity can proceed without increased Ser-1303 phosphorylation, and is unaffected by Dapk1 deficiency in vitro or following ischemia in vivo. Publication Status: Online-Only"
> "Q80YE7-1","RefSeq","NP_598823.1","28614711","Authors find that the LTP specificity of CaMKII synaptic accumulation is due to its LTD-specific suppression by calcineurin (CaN)-dependent DAPK1 activation, which in turn blocks CaMKII binding to GluN2B."
> "Q80YE7-1","RefSeq","NP_598823.1","14530257","Cellular activities of DAPK are critical for antagonizing caspase-dependent apoptosis to promote cell survival under normal cell growth conditions."
3925a5318,5319
> "Q60634-1","RefSeq","NP_032054.1","27993509","This study suggests that reggie-1 and reggie-2 function at Rab11a recycling containers in the transport of PSD-95, N-cadherin, GluA1 and GluN1, and promote (together with significant signaling molecules) spine-directed trafficking, spine synapse formation and the in vitro correlate of LTP. Erratum:[Exp Neurol. 2017 Jul;293:200. PMID: 28292530]"
> "Q60634-1","RefSeq","NP_032054.1","26313572","These results indicated that miR-124 could potentially play a role in caveolin-independent vesicle trafficking and modulation of flotillin-2 expression in mouse acrosome biogenesis. Publication Status: Online-Only"
3929a5324
> "P63042-1","RefSeq","NP_062649.1","17640754","These data indicate that the overexpression of stathmin disrupts dendritic microtubule,organization, motor protein distribution, and neural function in Purkinje cells."
3944a5340,5345
> "E9PZ87-1","RefSeq","NP_001078845.1","30445407","Pappa2 deletion is associated with bone resorption."
> "E9PZ87-1","RefSeq","NP_001078845.1","29238946","This review evaluates the current data concerning PAPP-A2 function, and particularly the effect of PAPP-A2 mutation on growth. Review article"
> "E9PZ87-1","RefSeq","NP_001078845.1","26385171","Locally-produced Pappa2 in osteoblasts, epiphysis, and metaphysis, is required for normal postnatal bone growth."
> "E9PZ87-1","RefSeq","NP_001078845.1","26164771","Despite a dramatic disruption of the balance between circulating IGF-I, IGFBP-3 and -5, we found no effects of Pappa2 deletion on glucose metabolism, weight gain or adiposity on a high-fat diet."
> "E9PZ87-1","RefSeq","NP_001078845.1","26416573","Pappa2 deletion had no effect on female reproduction and subtle effects on male fertility. Publication Status: Online-Only"
> "E9PZ87-1","RefSeq","NP_001078845.1","16702428","The refinement of the target region to four genes and the finding that the QTL affects IGFBP-5 levels suggest that PAPPA2 may be involved with normal postnatal growth"
3956a5358,5360
> "O35071-1","RefSeq","NP_694743.2","31217419","Study shows that the microtubule binding surface of Kif1c motor domain interacts with its stalk and that these autoinhibitory interactions are released upon binding of protein tyrosine phosphatase Ptpn21. The FERM domain of Ptpn21 stimulates dense core vesicle transport in primary hippocampal neurons and rescues integrin trafficking in Kif1c-depleted cells. Publication Status: Online-Only"
> "O35071-1","RefSeq","NP_694743.2","28096452","The melanocore-interacting Kif1c-tail (M-INK) probe localize melanosomes in keratinocytes."
> "O35071-1","RefSeq","NP_694743.2","23300462","By utilizing a forward genetic approach, we identified kinesin family member 1C (Kif1c) as a positional candidate for Orch3 and, using a transgenic approach, demonstrated that Kif1c is Orch3"
3976a5381,5389
> "Q9DA32-1","RefSeq","NP_083875.1","28945193","These studies reveal the essential role of SUN5 in anchoring sperm head to the tail and provide a promising way to treat this kind of acephalic spermatozoa-associated male infertility. Publication Status: Online-Only"
> "Q9DA32-1","RefSeq","NP_083875.1","25775128","In Dpy19l2 knock-out round spermatids, the detachment of the acrosome leads to Sun5 and lamin B1 relocalization, confirming that Sun5 protein is excluded from the nuclear envelope facing the acrosome. Erratum:[PLoS One. 2015;10(4):e0125452. Nahed, Roland Abi [corrected to Abi Nahed, Roland]. PMID: 25860994] Publication Status: Online-Only"
> "Q9DA32-1","RefSeq","NP_083875.1","21711156","SPAG4L may play an important role in the meiotic stage of spermatogenesis"
> "Q9DA32-1","RefSeq","NP_083875.1","21159740","SPAG4L-2 and SPAG4L are transmembrane proteins that localize to the nuclear envelope."
> "Q9DA32-1","RefSeq","NP_083875.1","17618558","SRG4 was cloned into pUCm-T vectors and sequenced, subcloned into a prokaryotic expression vector and expression of induced by IPTG."
> "Q9DA32-1","RefSeq","NP_083875.1","17650487","Results indicated that the expression of SRG4 was regulated by development, and SRG4 was mainly expressed in the cytoplasm of spermatocytes and round spermatids."
> "Q9EQF2-1","RefSeq","NP_115929.3","28836263","B cells require signaling from IFN-alpha/beta to produce alloantibodies to the human KEL glycoprotein in mice"
> "Q9EQF2-1","RefSeq","NP_115929.3","23122227","Absence of Kell was accompanied by changes in erythrocyte K(+), Mg(2+), Na(+) & Ca(2+) transport associated with changes in mean cellular volume & corpuscular hemoglobin concentration mean. Kel loss increased Mg(2+) permeability. Erratum:[Blood Cells Mol Dis. 2014 Jan;52(1):52]"
> "Q9EQF2-1","RefSeq","NP_115929.3","19544475","The targeted disruption of Kel in mouse enabled us to identify phenotypes that would not be easily detected in humans lacking Kell glycoprotein."
3983a5397,5405
> "Q91VH1-1","RefSeq","NP_082596.2","29512400","MiR-323-3p appears to be a crucial diabetes factor that mediates its functions by inhibiting the AdipoR1/AMPK/SIRT-1 signaling pathway."
> "Q91VH1-1","RefSeq","NP_082596.2","29304075","Although the physiological levels of adiponectin are sufficient to activate AMPK and Akt when AdipoR1 is overexpressed in beta-cells, yet adiponectin cannot protect beta-cells in Akita mice from ER stress-induced destruction Publication Status: Online-Only"
> "Q91VH1-1","RefSeq","NP_082596.2","29194451","Immunofluorescence indicated that GPRC6A and adiponectin receptor 1 were co-localized in mouse muscle tissues. The present finding suggested adiponectin receptor 1 can mediate the improvement of glucose metabolism by osteocalcin in ovariectomized mice Publication Status: Online-Only"
> "Q91VH1-1","RefSeq","NP_082596.2","15454091","A link between adiponectin and bone homeostasis by demonstrating transcription, translation, and secretion of adiponectin, as well as expression of its receptors, AdipoR1 and AdipoR2, in bone-forming cells"
> "Q91VH1-1","RefSeq","NP_082596.2","15358228","Expressed in islets, muscle and liver; expression in mouse islets related to dietary fat."
> "Q91VH1-1","RefSeq","NP_082596.2","15123605","Adiponectin receptor expression is regulated by insulin and Foxo1"
> "Q91VH1-1","RefSeq","NP_082596.2","12802337","Cloning of cDNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) by expression cloning [AdipoR1 & AdipoR2] Erratum:[Nature. 2004 Oct 28;431(7012):1123]"
> "Q8R316-1","RefSeq","NP_818774.2","29030964","HBP1 knockdown leads to a significant reduction of C/EBPa expression, suggesting that HBP1-mediated C/EBPa expression may be needed for the termination of the cell cycle at the end of MCE for terminal differentiation"
> "Q8R316-1","RefSeq","NP_818774.2","27206316","The regulation of Hbp1 conferred substantial protection of ovarian reserve."
3990a5413,5415
> "Q9Z2F2-1","RefSeq","NP_035984.2","30635239","These resulta define distinct mechanisms by which OASL differentially regulates host IFN responses during RNA and DNA virus infection and identify OASL as a negative-feedback regulator of cGAS"
> "Q02053-1","RefSeq","NP_033483.2","24948797","Inhibition of ubiquitin-activating enzyme E1 (Ube1) increases the levels of high- molecular weight mouse Htt in relatively unaffected tissues, declining in the nuclear fraction with age."
> "Q02053-1","RefSeq","NP_033483.2","24590288","Dysregulation of UBA1 and subsequent ubiquitination pathways led to beta-catenin accumulation in a model of spinal muscular atrophy."
3999a5425,5427
> "Q9D3P8-1","RefSeq","NP_080638.1","29495105","Plg-RKT is essential for lactogenesis and functions to maintain the appropriate stromal extracellular matrix environment, regulate epithelial cell proliferation and apoptosis, and, by regulating fibrinolysis, preserve alveolar and ductal patency."
> "Q9D3P8-1","RefSeq","NP_080638.1","21940822","Plg-R(KT) plays a key role in the plasminogen-dependent regulation of macrophage invasion, chemotactic migration, and recruitment in the inflammatory response."
> "Q9D3P8-1","RefSeq","NP_080638.1","21795689","Plg-R(KT) was highly expressed in bovine adrenomedullary chromaffin cells, human pheochromocytoma tissue, PC12 pheochromocytoma cells, and murine hippocampus."
4001,4004c5429
< "Q8CCE9-1","RefSeq","NP_001288713.1","27621446","These data identify E4F1 as a master regulator of the PDC."
< "Q8CCE9-1","RefSeq","NP_001288713.1","27621431","These data reveal a central role for Dlat in the metabolic program regulated by E4F1 in basal keratinocytes."
< "Q8CCE9-1","RefSeq","NP_001288713.1","25843721","Acute inactivation of E4F1 in these cells results in CHK1-dependent checkpoint deficiency and multiple mitochondrial dysfunctions that lead to increased ROS production, energy stress, and inhibition of de novo pyrimidine synthesis"
< "Q8CCE9-1","RefSeq","NP_001288713.1","25843717","Altogether, our results classify E4F1 as a master regulator of CHK1 activity that ensures high fidelity of DNA replication, thus safeguarding genome stability."
---
> "Q9CU65-1","RefSeq","NP_083774.2","21527531","The study demonstrates frequent, constitutive activation of Notch1 and its downstream target genes in T-cell lymphomas that arose in a murine model of Zmym2-Fgfr1 stem cell leukemia-lymphoma syndrome."
4014a5440,5441
> "Q8K443-1","RefSeq","NP_694811.1","21531726","P53 may modulate immune responses through suppression of RGS13 transcription in mast cells and B cells"
> "Q8K443-1","RefSeq","NP_694811.1","12193720","Rgs13 is strongly expressed in the germinal center regions of spleen, Peyer's patches, and thymic medulla, interacts with Gialpha and Gqalpha, and strongly inhibits both CXCL12- and CXCL13-induced signaling."
4016,4019d5442
< "Q9QXS6-1","RefSeq","NP_001170842.1","30625038","Neuronal drebrin A directly interacts with mDia2 formin."
< "Q9QXS6-1","RefSeq","NP_001170842.1","30317558","Versus micropinocytosis activities. Taken together, these findings now reveal that Dbn1 plays a major role in coordinating the actin cytoskeletal activities responsible for antigen presentation in DC."
< "Q9QXS6-1","RefSeq","NP_001170842.1","30700723","An excess of reactive oxygen species stimulates ATM-dependent phosphorylation of DBN at serine-647, which enhances protein stability and accounts for improved stress resilience in dendritic spines. Publication Status: Online-Only"
< "Q9QXS6-1","RefSeq","NP_001170842.1","12761245","Drebrin is involved in regulation of actin dynamics also outside the nervous system. Drebrin is one of the actin-binding proteins regulating the actomyosin system and the dynamics of mesangial cells and foot processes in podocytes."
4023a5447,5449
> "Q9Z2C5-1","RefSeq","NP_064310.2","28934386","Expression of several MTMR2 isoforms ameliorates the myopathic phenotype owing to MTM1 loss, with increased muscle force, reduced myofiber atrophy, and reduction of the intracellular disorganization hallmarks associated with myotubular myopathy."
> "Q9Z2C5-1","RefSeq","NP_064310.2","12467733","The investigation of the MTM1 gene and X-inactivation studies are indicated in isolated females with histopathological and clinical findings suggestive of myotubular myopathy."
> "Q9Z2C5-1","RefSeq","NP_064310.2","12391329","Essential for skeletal muscle maintenance but not for myogenesis"
4028a5455,5462
> "P70280-1","RefSeq","NP_035645.1","30215699","VAMP7 participates in autophagosome formation by supporting Atg9a functions that contribute to maintenance of mitochondrial quality."
> "P70280-1","RefSeq","NP_035645.1","28392418","Spastin regulates VAMP7-containing vesicles trafficking in cortical neurons."
> "P70280-1","RefSeq","NP_035645.1","27482051","VAMP7 mediates fusion of BLOC-1-dependent transport carriers with melanosomes, illuminate SNARE recycling from melanosomes as a critical BLOC-3-dependent step."
> "Q03717-1","RefSeq","NP_032446.2","30820446","Kv8.2 knock-out (KO) mice show many similarities to human cone dystrophy with a supernormal rod response, including a depressed a-wave and an elevated b-wave response with bright light stimulation. Optical coherence tomography imaging and immunohistochemistry indicate that the changes in six-month-old Kv8.2 KO retinae are largely limited to the outer nuclear layer, while outer segments appear intact. Publication Status: Online-Only"
> "Q03717-1","RefSeq","NP_032446.2","30091655","These findings demonstrate a conserved in vivo function for Kv2 family members in remodeling neuronal endoplasmic reticulum-plasma membrane junctions."
> "Q03717-1","RefSeq","NP_032446.2","30012696","Expression of Kv2.1 recruits VAPB and VAPA to ER-PM junctions. Knocking out VAPA expression disrupts Kv2.1 clustering.The domains of VAPs and Kv2.1 necessary and sufficient for their association at ER-PM junctions were identified. Kv2.1 expression in the plasma membrane can affect ER-PM junctions via its phosphorylation-dependent association to ER-localized VAPA and VAPB."
> "Q03717-1","RefSeq","NP_032446.2","28504671","Spinal Musculature Atrophy motor neurons showed a lower surface expression of Kv2.1 potassium channels and reduced spiking ability."
> "Q64362-1","RefSeq","NP_034371.1","26110528","Ft1 protein is required for telomere maintenance. Publication Status: Online-Only"
4029a5464,5470
> "O54967-1","RefSeq","NP_058068.2","28189676","MiR-24 represses metastasis of osteosarcoma cells by targeting Ack1 via AKT-MMP2-MMP9 pathway."
> "O54967-1","RefSeq","NP_058068.2","28188290","Findings identify ACK1 as a novel SLP-76-associated protein-tyrosine kinase that modulates early activation events in T cells."
> "O54967-1","RefSeq","NP_058068.2","26621748","That the cdc42-activated, nonreceptor tyrosine kinase, Ack1, is a DAT endocytic brake that stabilizes DAT at the plasma membrane."
> "O54967-1","RefSeq","NP_058068.2","22952966","ACK1 directly binds and phosphorylates the Arp2/3 regulatory protein cortactin, potentially providing a direct link to Arp2/3-based actin dynamics during EGFR degradation."
> "O54967-1","RefSeq","NP_058068.2","16750431","Ack1 is up-regulated during development and is expressed in proliferative areas and in migratory pathways in the developing brain."
> "O54967-1","RefSeq","NP_058068.2","16777958","These experiments suggest a functional role for Ack as an early transducer of multiple extracellular stimuli."
> "O54967-1","RefSeq","NP_058068.2","16052498","Ack1/Pyk1 tyrosine kinase may be involved both in adult synaptic function and plasticity and in brain development."
4035,4038c5476,5477
< "Q08048-1","RefSeq","NP_001276387.1","30627913","It can be assumed that Sema3a synthesized in the thymus stroma can act as a functional antagonist of HGF and KGF and have an inhibitory effect when these growth factors are administered into the body for the therapeutic purpose of restoring thymus functions."
< "Q08048-1","RefSeq","NP_001276387.1","30401749","Activation of hepatocyte growth factor/MET signaling initiates oncogenic transformation and enhances tumor aggressiveness in the murine prostate."
< "Q08048-1","RefSeq","NP_001276387.1","30103949","C-Fos is necessary for HGF-mediated gene regulation and cell migration in Schwann cells."
< "Q08048-1","RefSeq","NP_001276387.1","30066918","These results suggested that HGF may exert beneficial effects on type II diabetesinduced chronic renal failure via regulation of the NFkappaB signaling pathway."
---
> "O88700-1","RefSeq","NP_031576.4","29348659","In the absence of BLM, sister chromatid exchange events do not occur randomly throughout the genome but are strikingly enriched at coding regions, specifically at sites of guanine quadruplex motifs in transcribed genes. Publication Status: Online-Only"
> "O88700-1","RefSeq","NP_031576.4","28912125","The anti-recombinase activity of BLM is of general importance for normal retention of RAD51 at DNA double strand break sites and regulation of homologous recombination."
4042a5482,5484
> "Q8VDQ1-1","RefSeq","NP_084156.2","17449869","15-oxoprostaglandin-Delta13-reductase (PGR-2) catalyzes the reaction converting 15-keto-PGE2 to 13,14-dihydro-15-keto-PGE2"
> "Q8VDQ1-1","RefSeq","NP_084156.2","15229897","This mouse gene encodes a putative NADPH-dependent oxidoreductase. We report the crystal structure of the putative oxidoreductase determined by the semi-automated high-throughput pipeline of the Joint Center for Structural Genomics"
> "O08901-1","RefSeq","NP_033902.2","26031201","Bub1 coordinates checkpoint signalling by distinct domains for RZZ and BubR1 recruitment and localizes antagonistic checkpoint activities. Publication Status: Online-Only"
4061a5504,5505
> "Q8R420-1","RefSeq","NP_038883.2","16612327","Showed for the first time expression and subcellular localization of abcb11 and abca3 in mouse kidney"
> "Q8R420-1","RefSeq","NP_038883.2","11940594","Identification of LBM180, a lamellar body limiting membrane protein of alveolar type II cells, as the ABC transporter protein ABCA3"
4063a5508,5515
> "Q99J31-1","RefSeq","NP_443208.1","29030432","Ophn1 deficiency generates severe impairments in performance at spatial working memory tests."
> "Q99J31-1","RefSeq","NP_443208.1","27742778","Furthermore, we found that olfactory behaviour was perturbed in OPHN1 ko mice. Chronic treatment with a Rho kinase inhibitor rescued most of the defects of the newly generated neurons. Altogether, our data indicated that OPHN1 plays a key role in regulating the number, morphology and function of adult-born inhibitory interneurons and contributed to identify potential therapeutic targets."
> "Q99J31-1","RefSeq","NP_443208.1","27117132","OPHN1 mediated regulation of RhoA, Rac1 and Cdc42 is crucial for the preservation of cardiac function after myocardial injury."
> "Q99J31-1","RefSeq","NP_443208.1","27146843","Here, we report that chronic treatment in adult mouse with Fasudil, is able to counteract vertical and horizontal hyperactivities, restores recognition memory and limits the brain ventricular dilatation observed in Ophn1(-)(/y) However, deficits in working and spatial memories are partially or not rescued by the treatment"
> "Q99J31-1","RefSeq","NP_443208.1","19401298","Loss of OPHN1 leads to the activation of the RhoA/ROCK signaling pathway."
> "Q99J31-1","RefSeq","NP_443208.1","19481455","Results sugest that reduced or defective OPHN1 signaling impairs synaptic vesicle cycling at hippocampal synapses."
> "Q99J31-1","RefSeq","NP_443208.1","17728457","This study indicates that cognitive impairment related to OPHN1 loss of function is associated with both presynaptic and postsynaptic alterations."
> "Q99J31-1","RefSeq","NP_443208.1","12932438","Oligophrenin-1 is expressed in developing CNS areas that evince synaptic plasticity. OPHN1 is expressed in both glial and neuronal cells, where it colocalizes with actin at the tip of growing neurites."
4065,4068d5516
< "Q925P2-1","RefSeq","NP_001106839.1","27161904","Disruption of CEACAM2 induces a moderate integrin alphaIIbbeta3-mediated platelet function defect, and that CEACAM2 is essential to maintain a normal integrin alphaIIbbeta3-mediated platelet function."
< "Q925P2-1","RefSeq","NP_001106839.1","26586918","CEACAM2 regulates insulin secretion, at least in part, by a GLP-1-mediated mechanism, independent of confounding metabolic factors."
< "Q925P2-1","RefSeq","NP_001106839.1","25085348","Functional studies of platelets from Ceacam2(-/-)-deficient mice (Cc2(-/-)) revealed that CEACAM2 serves to negatively regulate collagen glycoprotein VI (platelet) (GPVI)-FcRgamma-chain and the C-type lectinlike receptor 2 (CLEC-2) signaling"
< "Q925P2-1","RefSeq","NP_001106839.1","24948196","Sertoli cells recognize the excess cytoplasm of elongated spermatids through the PVR-CEACAM2-L interaction in mouse testis"
4081a5530,5532
> "Q6ZPI0-1","RefSeq","NP_758507.3","26919559","Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis."
> "Q6ZPI0-1","RefSeq","NP_758507.3","24097061","LncRNA-JADE is a key functional link that connects the DDR to histone H4 acetylation, and that dysregulation of lncRNA-JADE may contribute to breast tumorigenesis."
> "Q6ZPI0-1","RefSeq","NP_758507.3","14612400","Exhibits a regulated expression during embryogenesis and localizes to the nucleus and/or cytoplasm of different cell types"
4083a5535,5542
> "Q8R1X6-1","RefSeq","NP_659144.1","28324774","Findings evidence a positive correlation between SIRT1 and BCL6 expression increase in follicular lymphomas (FL) . SIRT1 methylation decreases in FL and diffuse large-B cell lymphomas (DLBCL)and this parallels the increase of KLF4, DAPK1 and SPG20 methylation"
> "Q8R1X6-1","RefSeq","NP_659144.1","27112432","Here we report the case of three patients of Filipino descent with Troyer syndrome. Whole exome sequencing (WES) identified a homozygous mutation c.364_365delAT which predicts p.Met122Valfs*2 in SPG20"
> "Q8R1X6-1","RefSeq","NP_659144.1","24523286","Spartin, via the ubiquitin-binding region, binds Lys-63-linked ubiquitin chains but does not bind Lys-48-linked ubiquitin chains.  spartin's role in DALIS formation depends on key residues within its ubiquitin-binding region."
> "Q8R1X6-1","RefSeq","NP_659144.1","22982304","Alsin and spartin may interact each other physically"
> "Q8R1X6-1","RefSeq","NP_659144.1","22619377","A role for spartin in lipid droplets maintenance and in the regulation of cytokinesis"
> "Q8R1X6-1","RefSeq","NP_659144.1","21559443","SPG20 protein spartin associates with cardiolipin via its plant-related senescence domain and regulates mitochondrial Ca2+ homeostasis Publication Status: Online-Only"
> "Q8R1X6-1","RefSeq","NP_659144.1","16036216","Our results suggest that spartin might be involved in endocytosis, vesicle trafficking, or mitogenic activity, and that impairment in one of these processes may underlie the long axonopathy in patients with Troyer syndrome."
> "Q8R242-1","RefSeq","NP_083112.1","22465033","In di-N-acetylchitobiase-deficient mice Man2GlcNAc2 urine levels were up to 10-fold higher than in urine of wild-type animals."
4098c5557
< "Q3TMX7-1","RefSeq","NP_001289885.1","29800099","Our study provides the first comprehensive comparisons between QSOX1 and QSOX2 in the mouse epididymis, revealing their distinct epididymal distribution, cellular localization, mechanisms of secretion and sperm membrane association"
---
> "Q9CYR6-1","RefSeq","NP_082628.3","17548465","Two hypomorphic alleles of mouse Pgm3 are described and specific physiological consequences of a graded reduction in Pgm3 activity and global UDP-GlcNAc levels, are shown."
4100a5560,5562
> "O09116-1","RefSeq","NP_035608.1","25278290","SPRR3 protects an atheroma lesion from vascular smooth muscle cell (VSMC) loss by promoting survival signaling in plaque VSMCs, thereby significantly decreasing atherosclerosis progression."
> "O09116-1","RefSeq","NP_035608.1","18832573","These data suggest that SPRR3 may play a role in vascular smooth muscle cells adaptation to local biomechanical stress within the plaque microenvironment."
> "O09116-1","RefSeq","NP_035608.1","17935133","Esophagin/SPRR3 may play a role in the maintenance of normal esophageal epithelial homeostasis, and aberrant expression of Esophagin/SPRR3 may contribute to the tumorigenesis of esophageal squamous cell carcinoma"
4102a5565,5569
> "P10166-1","RefSeq","NP_032532.1","27298335","Deletion of Mycl in two genetically engineered models of SCLC resulted in strong suppression of SCLC"
> "P10166-1","RefSeq","NP_032532.1","24509714","Mycl1 is expressed exclusively by dendritic cells; unlike c-Myc, the L-Myc transcription factor is not repressed by interferons, and its expression allows for optimal dendritic cell proliferation and T-cell priming in the presence of inflammation"
> "Q8BYJ6-1","RefSeq","NP_001074747.2","29170369","Fkbp5 knockouts are protected from high-fat diet-induced weight gain, show improved glucose tolerance and increased insulin signaling in skeletal muscle. We identify a novel association between FKBP51 and AS160, a substrate of AKT2 that is involved in glucose uptake. FKBP51 antagonism increases the phosphorylation of AS160. Publication Status: Online-Only"
> "Q8BYJ6-1","RefSeq","NP_001074747.2","27929607","Rab28 is a substrate for the GAP domains of both TBC1D1 and TBC1D4 in vitro."
> "Q8BYJ6-1","RefSeq","NP_001074747.2","11994271","AS160 was shown to be a substrate for Akt, and two sites of phosphorylation, both in RXRXXS/T motifs, were identified by mass spectrometry and mutation"
4117,4120c5584
< "Q6NZL8-1","RefSeq","NP_001258401.1","30414502","SCUBE1 directly binds to BMP7 and its receptors, functioning as a BMP co-receptor to promote BMP7 signaling."
< "Q6NZL8-1","RefSeq","NP_001258401.1","20042401","SCUBE1 may be involved in the regulation of tubular cell proliferation and re-epithelialization during the resolution of kidney injury."
< "Q6NZL8-1","RefSeq","NP_001258401.1","19101956","During tooth development, Scube1 localized to the dental papilla of both incisor and molar teeth, suggestina a role for Scube1 during early craniofacial development."
< "Q6NZL8-1","RefSeq","NP_001258401.1","18303018","These results support the dual roles of SCUBE1 on brain morphogenesis and cell-cell adhesions through its distinct domain function."
---
> "P97931-1","RefSeq","NP_035807.2","28775312","We showed that SMUG1 efficiently prevent genomic uracil accumulation, even in the presence of UNG, and identified mutational signatures associated with combined UNG and SMUG1 deficiency. Publication Status: Online-Only"
4125,4131c5589,5590
< "Q3UHC7-1","RefSeq","NP_001107596.1","27476001","PROX1 overexpression in DAB2IP-deficient prostate cancer cells could enhance the accumulation of HIF1alpha protein by inhibiting ubiquitin pathway and then consequently induce an epithelial-mesenchymal transition response."
< "Q3UHC7-1","RefSeq","NP_001107596.1","26512963","DAB2IP loss reprograms intracellular signal transduction and anti-apoptotic gene expression, which potentiates prostate cancer cell survival from androgen deprivation therapy-induced cell death. Publication Status: Online-Only"
< "Q3UHC7-1","RefSeq","NP_001107596.1","26139244","Our data reveal that AIP1, by inhibiting VEGFR2-dependent signaling in tumor niche, suppresses tumor EMT switch, tumor angiogenesis, and tumor premetastatic niche formation to limit tumor growth and metastasis."
< "Q3UHC7-1","RefSeq","NP_001107596.1","26181199","Germ cell-specific or Sertoli cell-specific deletion of Aip1 gene each led to significant defects in germ cell migration after postnatal day 4 or 5, accompanied by elevated levels of actin filaments (F-actin) in the affected cells. Publication Status: Online-Only"
< "Q3UHC7-1","RefSeq","NP_001107596.1","25995115","Cor1B, Cof1 and AIP1 work in concert through a temporally ordered pathway to induce highly efficient severing and disassembly of actin filaments. Publication Status: Online-Only"
< "Q3UHC7-1","RefSeq","NP_001107596.1","18281285","AIP1 is essential for transducing the IRE1-mediated endoplasmic reticulum stress response."
< "Q3UHC7-1","RefSeq","NP_001107596.1","12877983","This study suggests that Dab2IP may function as a downstream effector in the Reelin signaling pathway that influences Ras signaling during brain development."
---
> "Q9JMA7-1","RefSeq","NP_059092.2","21088200","Data suggest that modification of histones bound to Cyp3a41 gene contributes to sex specificity of Cyp3a41 expression by controlling access of HNF4 to DNA."
> "Q9JMA7-1","RefSeq","NP_059092.2","14733933","Cyp3a41 gene expression is regulated by growth and glucocorticoid hormones"
4138a5598,5602
> "Q9WVC8-1","RefSeq","NP_067328.1","30118583","SLC26A3 is essential for sperm motility and protein tyrosine phosphorylation during mouse sperm capacitation process."
> "Q9WVC8-1","RefSeq","NP_067328.1","29330471","Role in protecting the intestinal epithelial barrier"
> "Q9WVC8-1","RefSeq","NP_067328.1","29286110","TNFalpha may act reciprocally with DRA, leading to the development of intestinal inflammation."
> "Q9WVC8-1","RefSeq","NP_067328.1","28823863","In intestinal cells, TNF activates NF-kappaB, which reduces expression of the Cl(-) / HCO3(-) exchanger SLC26A3, via direct binding to the promoter region."
> "Q9WVC8-1","RefSeq","NP_067328.1","16901991","In Slc26a6-knockout mice, a robust Slc26a3 compensatory upregulation can replace the function of Slc26a6 in pancreatic ducts."
4140a5605,5616
> "P97805-1","RefSeq","NP_666162.1","29853563","FAM3D, as a dual agonist of FPR1 and FPR2, induced Mac-1-mediated neutrophil recruitment and aggravated abdominal aortic aneurysm development through FPR-related Gi protein and beta-arrestin signaling."
> "P97805-1","RefSeq","NP_666162.1","22226334","Fam3D is a gut-derived protein that is expressed and secreted in a nutritional status-dependent manner"
> "Q9JKC8-1","RefSeq","NP_061299.3","27568566","These data suggest that excess mu3A acts independently of the AP-3A complex to reroute AMPAR to recycling endosomes."
> "Q9JKC8-1","RefSeq","NP_061299.3","23404500","Structural basis for the recognition of tyrosine-based sorting signals by the mu3A subunit of the AP-3 adaptor complex"
> "P62484-1","RefSeq","NP_937760.1","22617848","This study demonstrated that WAVE2-Abi2 complex, which controls growth cone activity, is crucial for completing transition from a multipolar to bipolar shape."
> "Q924H0-1","RefSeq","NP_573455.2","30413707","NPFFR2 signalling promotes diet-induced thermogenesis. Publication Status: Online-Only"
> "Q924H0-1","RefSeq","NP_573455.2","29709623","These data underlie kisspeptin's hyperalgesic action and argues for the role of kisspeptin receptor 1 in the mediation of its action. Furthermore, our results suggest that central KP-13 administration can modify the acute effects of morphine."
> "Q924H0-1","RefSeq","NP_573455.2","28825666","We demonstrate, for the first time, that NPFFR2 positively modulates the HPA axis via hypothalamic corticotropin-releasing factor (CRF). Our finding that NPFFR2 regulates stress-dependent neural pathways advances our understanding of neuroendocrine regulation and opens new avenues for probing the functions of NPFF. Publication Status: Online-Only"
> "Q924H0-1","RefSeq","NP_573455.2","28179153","The results of this study demonstrated that NPFFR2 activation modulates pain transmission by up-regulating the pain mediator CGRP, leading to hyperalgesia."
> "Q924H0-1","RefSeq","NP_573455.2","19944730","Species-related differences in the binding properties of NPFF(2) receptors"
> "Q924H0-1","RefSeq","NP_573455.2","17157836","NPFF system may also have species-specific features since the NPFF2 receptor mRNA expression differs from that reported for rat"
> "Q924H0-1","RefSeq","NP_573455.2","14696013","The distribution pattern of NPFF2 receptors in the diencephalon and the superficial layers of the spinal cord is consistent with a hypothesized potential role for NPFF in the modulation of sensory input and opioid analgesia."
4146a5623,5626
> "Q3TQ03-1","RefSeq","NP_001028474.1","24737000","CHRONO interferes with the ability of BMAL1 to recruit CBP, a bona fide histone acetylase and key transcriptional coactivator of the circadian clock. Publication Status: Online-Only"
> "Q3TQ03-1","RefSeq","NP_001028474.1","24736997","Chrono binds to the regulatory region of clock genes and its occupancy oscillates in a circadian manner. Publication Status: Online-Only"
> "Q3TQ03-1","RefSeq","NP_001028474.1","24385426","The GM129 protein contributes to the transcriptional feedback loop by modulating CLOCK.BMAL1 activity as a transcriptional repressor."
> "Q8C708-1","RefSeq","NP_849232.1","21498670","These findings indicate that AI467606 is a novel transcriptional target of RUNX1/AML1 at the onset of hematopoietic development that is extensively expressed within the hematopoietic system"
4157,4162d5636
< "Q80VP1-1","RefSeq","NP_001239383.1","30102256","Diabetes attenuated VEGF-C-induced lymphangiogenesis in corneal micropocket and Matrigel plug assays in WT mice but not in mice with inducible lymphatic-specific deficiency of epsins 1 and 2 (LEC-iDKO)."
< "Q80VP1-1","RefSeq","NP_001239383.1","25871009","Epsins are required for Dishevelled stability and Wnt signalling activation in colon cancer development. Publication Status: Online-Only"
< "Q80VP1-1","RefSeq","NP_001239383.1","25314967","Epsins 1 and 2 have a critical role in the temporal and spatial regulation of VEGFR3 abundance and signaling in collecting lymphatic trunks during lymphatic valve formation Publication Status: Online-Only"
< "Q80VP1-1","RefSeq","NP_001239383.1","23187125","Loss of epsins 1 and 2 impaired endocytosis and degradation of VEGFR2, resulting in excessive VEGF signaling and compromised tumor vascular function."
< "Q80VP1-1","RefSeq","NP_001239383.1","19666558","Epsin has a role as a specialized endocytic adaptor, with a critical role in the activation of Notch signaling in mammals"
< "Q80VP1-1","RefSeq","NP_001239383.1","16574660","Epsin is an accessory protein linking ENaC to the clathrin-based endocytic machinery thereby regulating the activity of this ion channel at the cell surface"
4165a5640,5644
> "Q8BZM1-1","RefSeq","NP_573511.2","29191979","Shigella hijacks the glomulin-cIAP1-cIAP2-inflammasome axis to promote inflammation."
> "Q8BZM1-1","RefSeq","NP_573511.2","25246571","Results indicate a bacterial adaptation that hijacks inflammasome activation via interactions between IpaH7.8 E3 ubiquitin ligase and glomulin (GLMN)."
> "Q8BZM1-1","RefSeq","NP_573511.2","15053987","The glomulin expression during murine development (E9.5 days post-coitum until adulthood) by non-radioactive in situ hybridization was studied."
> "Q08509-1","RefSeq","NP_031971.2","30314980","Scrutinized the motility of Hnrnpab(-/-) cells and confirmed that the decreases in both cell motility and Eps8 are restored by ectopically coexpressing both alternatively spliced Hnrnpab isoforms, therefore these variants are surprisingly nonredundant for cell motility."
> "Q08509-1","RefSeq","NP_031971.2","27450093","Results implicate N-methyl-d-aspartate receptor hyperfunction in the cognitive deficits observed in Epidermal growth factor receptor substrate 8 (Eps8) knockout mice and demonstrate a novel role for Eps8 in regulating hippocampal long-term synaptic plasticity and cognitive function."
4170a5650,5656
> "Q9Z188-1","RefSeq","NP_034222.1","30317528","Through the activation of DYRK1B, Hedgehog signaling facilitates microtubule-dependent processes such as intracellular mitochondrial transport, mesenchymal cell polarization or directed cell migration."
> "Q9Z188-1","RefSeq","NP_034222.1","29030970","We demonstrated that Anxa1, Anxa2, and Dyrk1b are upregulated at both the transcriptional and translational levels by the overexpression of GAS1"
> "Q9Z188-1","RefSeq","NP_034222.1","24312406","Results suggest that functional interactions between BM88/Cend1, RanBPM and Dyrk1B affect the balance between cellular proliferation and differentiation in Neuro 2a cells Publication Status: Online-Only"
> "Q9Z188-1","RefSeq","NP_034222.1","22711815","Cirp functions to fine-tune the proliferation of undifferentiated spermatogonia by interacting with Dyrk1b."
> "Q9Z188-1","RefSeq","NP_034222.1","18818203","BCL2 and BCL-xL facilitation of G0 quiescence requires BAX, BAK, and p27 phosphorylation by Mirk"
> "Q9Z188-1","RefSeq","NP_034222.1","12902328","Dyrk1B is a Rho-induced kinase active in skeletal muscle differentiation"
> "Q9Z188-1","RefSeq","NP_034222.1","12384504","P38 MAP Kinase suppresses the function of Mirk as a transcriptional activator only when cells are proliferating"
4175a5662,5669
> "Q1HKZ5-1","RefSeq","NP_766409.2","28641113","LZK cooperates with DLK to promote retinal ganglion cell death in response to axon injury."
> "Q1HKZ5-1","RefSeq","NP_766409.2","27511108","By gain- and loss-of-function analyses in neuronal cultures, the authors identify LZK as a novel positive regulator of axon growth. Publication Status: Online-Only"
> "Q1HKZ5-1","RefSeq","NP_766409.2","20926658","Scaffold protein POSH, in association with Shroom3 and mixed lineage kinase LZK, relays axon outgrowth inhibition downstream of NogoA and PirB proteins."
> "P52592-1","RefSeq","NP_034463.2","30761838","Studied the role of sphingosine-1-phosphate receptor 2 (S1PR2) (and S1PR2 deficiency) on neuropathic pain in a knockout mouse model. Publication Status: Online-Only"
> "P52592-1","RefSeq","NP_034463.2","29620575","S1PR2 deficiency decreased macrophage pyroptosis and improved survival in E.coli sepsis."
> "P52592-1","RefSeq","NP_034463.2","29453251","Novel adipokine, FAM19A5, was capable of inhibiting postinjury neointima formation via sphingosine-1-phosphate receptor 2-G12/13-RhoA signaling."
> "P52592-1","RefSeq","NP_034463.2","29782549","S1PR2 facilitates lung fibrosis through the mechanisms involving augmentation of IL-13 expression and its signaling in BALF cells. Publication Status: Online-Only"
> "P52592-1","RefSeq","NP_034463.2","11908758","Enhanced EDG5 signaling plays an important role in the proliferation of kidney mesangial cells and the progression of immunoglobulin A nephropathy."
4189a5684,5686
> "Q5SPX1-1","RefSeq","NP_808284.2","17971504","4930562D19Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
> "P63037-1","RefSeq","NP_032324.1","20363747","Hsc70 and a dimer of DjA1 independently bind to an unfolded protein"
> "P63037-1","RefSeq","NP_032324.1","15660130","Loss of DjA1 in led to severe defects in spermatogenesis that involve aberrant androgen signaling"
4197a5695,5701
> "Q80XE1-2","RefSeq","NP_898995.1","29118104","Olfactory-specific Ric-8b knock-out mice of mixed sex do not express the Galphaolf protein in the olfactory epithelium. The mature olfactory sensory neuron layer is reduced and cell death increased. These mice have an impaired sense of smell. Ric-8b is essential for olfactory function, and it may also be essential for Galphaolf-dependent functions in the brain. Erratum:[J Neurosci. 2018 Jan 24;38(4):1054. PMID: 31329690]"
> "Q80XE1-2","RefSeq","NP_898995.1","26062014","Data show that the localization of maternally expressed RIC8 protein is highly dynamic and is dependent on the stage of folliculogenesis, oogenesis and cleavage, and imply that it may have a regulatory function in mammalian gametogenesis. Publication Status: Online-Only"
> "Q80XE1-2","RefSeq","NP_898995.1","24585571","Results indicate that a functional N-terminus in C/EBPbeta-LAP* is required for interacting with SWI/SNF and for Ric-8B gene repression in osteoblasts."
> "Q80XE1-2","RefSeq","NP_898995.1","24134321","A new role of Ric-8B in the crosstalk of two distinct G protein signaling pathways, which are possibly involved in a part of mechanisms of chronic heart failure."
> "Q80XE1-2","RefSeq","NP_898995.1","20133939","Ric-8B plays a critical and specific role in the control of G alpha(s) protein levels by modulating G alpha(s) ubiquitination and positively regulates G(s) signaling"
> "Q80XE1-2","RefSeq","NP_898995.1","18462949","Ric-8B interacts with two different olfactory G protein subunits and is implicated as an important protein in odorant signal transduction."
> "Q80XE1-2","RefSeq","NP_898995.1","16754875","Results show that Ric-8B, a putative guanine nucleotide exchange factor for Galphaolf, promotes efficient heterologous expression of odorant receptors."
4202d5705
< "Q6P1D5-1","RefSeq","NP_001240845.1","27716410","Study demonstrates that SEZ6 and SEZ6L are physiological BACE1 substrates in the murine brain and suggests that sSEZ6 and sSEZ6L levels in CSF are suitable markers to monitor BACE1 inhibition in mice Publication Status: Online-Only"
4206,4208d5708
< "O54946-1","RefSeq","NP_001033029.1","21972064","Mrj(-/-) chorions at embryonic day 8.5 have expanded Rhox4b expression domains and do not form normal layers of gene expression suggesting that chorion patterning requires Mrj."
< "O54946-1","RefSeq","NP_001033029.1","19777589","Data show that Mrj(-/-) embryos exhibit neural tube defects independent of the placenta phenotype, including exencephaly and thin-walled neural tubes, and suggest that Mrj plays an important role in neural stem cell self-renewal."
< "O54946-1","RefSeq","NP_001033029.1","18373498","DnaJB6 is necessary for translocation of Slfn1 into the nucleus, where Slfn1 down-regulates cyclin D1, induces cell-cycle arrest and programmes a quiescent state of T-cells"
4211,4218d5710
< "Q8VBT3-1","RefSeq","NP_001277306.1","23817038","OSCAR expression in monocytic cells is regulated by proatherogenic stimuli further pointing towards a role in vascular inflammation or plaque vulnerability during atherosclerosis"
< "Q8VBT3-1","RefSeq","NP_001277306.1","21841309","Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice."
< "Q8VBT3-1","RefSeq","NP_001277306.1","18762192","Results indicate that USFs 1 and 2 serve as modulators in the induction of OSCAR and RANKL-mediated osteoclastogenesis."
< "Q8VBT3-1","RefSeq","NP_001277306.1","17442941","The overexpression of PIAS3 attenuates osteoclast formation and down-regulates the expression of NFATc1 and osteoclast-associated receptor (OSCAR), which are important modulators in osteoclastogenesis."
< "Q8VBT3-1","RefSeq","NP_001277306.1","16109714","Analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1, involving NFATc1-mediated OSCAR expression and its subsequent activation of NFATc1, necessary for efficient differentiation of osteoclasts"
< "Q8VBT3-1","RefSeq","NP_001277306.1","16046394","OSCAR but not TREM-2 is involved in the positive feedback loop of the immunoreceptor-NFATc1 pathway during osteoclastogenesis"
< "Q8VBT3-1","RefSeq","NP_001277306.1","15184345","The FcRgamma-mediated signal transduction by OSCAR is involved in osteoclast differentiation"
< "Q8VBT3-1","RefSeq","NP_001277306.1","12695521","PU.1 and MITF transcription factors synergistically activate OSCAR gene expression, which is further enhanced by the TRANCE-induced MKK6/p38 signaling cascade."
4220d5711
< "P16305-1","RefSeq","NP_001093111.1","29673739","The GABRA6 SNP rs3219151 has been significantly associated with alcohol dependence in studies on the Taiwanese Han, Korean, Finnish and South-western Native American populations."
4222a5714
> "Q9CQX5-1","RefSeq","NP_741968.1","28244141","Suggest that the transient decrease of CLDND1 after cerebellar hemorrhage is responsible for low-molecular-weight selective vascular hyperpermeability"
4223a5716,5721
> "P32766-1","RefSeq","NP_034108.1","23269664","A 14-kDa CRES isoform resides in the outer dense fibers of the sperm tail. Publication Status: Online-Only"
> "P32766-1","RefSeq","NP_034108.1","22827436","CRES may be a regulator of PC4 in sperm-egg interaction and fertilization."
> "P32766-1","RefSeq","NP_034108.1","23185254","Data on the antimicrobial activities of CRES protein suggest that it is a novel and innate antimicrobial protein which protecting the male reproductive tract against invading pathogens"
> "P32766-1","RefSeq","NP_034108.1","21051588","Loss of CRES has a significant impact on the structure and functions of the testis and epididymis. However, the observed pathologies were prevalent in aged but not in younger adult mice, suggesting that the effects of the loss of CRES are cumulative"
> "P32766-1","RefSeq","NP_034108.1","20811015","These results suggest that mice lacking CRES may have altered local levels of cAMP/PKA activity, or that the CRES defect does not directly involve cAMP/PKA but other signaling pathways that regulate protein tyrosine phosphorylation and capacitation."
> "P32766-1","RefSeq","NP_034108.1","12479114","CRES is a new cross-class inhibitor that may regulate PC2 of PC2-like proteases and suggests a role for CRES in the regulation of prohormone and proprotein processing. Review article"
4228a5727,5730
> "P26187-1","RefSeq","NP_032624.1","28753207","This study shows that when cell death and cell cycle arrest pathways are inhibited, p53 can still mediate MGMT-dependent repair, to promote cell survival upon DNA damage."
> "P26187-1","RefSeq","NP_032624.1","27618784","Snell, GHKRO, and PAPPA-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT) and N-myc downstream-regulated gene 1 (NDRG1)."
> "P26187-1","RefSeq","NP_032624.1","26243310","This study demonstrates for the first time a non-linear dose-response for alkylation-induced colorectal carcinogenesis and reveals DNA repair by MGMT, but not AAG, as a key node in determining a carcinogenic threshold."
> "Q9CZC8-1","RefSeq","NP_081544.1","29273527","While acute aerobic exercise increased Sesn1 accumulation and induced a discrete augment of Sesn2 protein content and AMPK threonine phosphorylation, chronic exercise reduced the basal levels of Sesn1 and Sesn2 as well as of AMPK threonine phosphorylation in the quadriceps muscles of C57BL/6J mice."
4234a5737,5740
> "P27546-1","RefSeq","NP_032659.2","30327268","Data reveal for the first time that MAP4 drives pathological cardiac remodeling through its phosphorylation. These findings bear the therapeutic potential to ameliorate pathological cardiac remodeling by attenuating MAP4 phosphorylation."
> "P27546-1","RefSeq","NP_032659.2","25898002","A novel isoform of MAP4 organizes the paraxial microtubule array required for muscle cell differentiation. Publication Status: Online-Only"
> "Q499D0-1","RefSeq","NP_899009.2","23133627","MIRN574 microRNA, mouse/*METAB"
> "Q499D0-1","RefSeq","NP_899009.2","20691664","The Foxn3 mutation leads to partial embryonic and postnatal lethality, growth retardation, eye formation defects, dental anomalies and craniofacial defects."
4238a5745,5749
> "Q8CBD1-1","RefSeq","NP_775616.1","30761836","Studied role of microRNA 33 (miR-33) and nuclear receptor interacting protein 1 (RIP140) in a model of acute lung injury Publication Status: Online-Only"
> "Q8CBD1-1","RefSeq","NP_775616.1","30190322","Disruption of a nuclear co-repressor of catabolism, the Nrip1 gene, in white adipocytes enhanced adipocyte browning with a marked increase of uncoupling protein 1 expression."
> "Q8CBD1-1","RefSeq","NP_775616.1","29346516","Deletion of Nrip1 can significantly extend longevity of female mice (log-rank test, p = .0004). We also found that Nrip1 expression is altered differently in various tissues during aging and under diet restriction. Remarkably, Nrip1 expression is elevated with aging in visceral white adipose tissue, but significantly reduced after 4 months of diet restriction."
> "Q8CBD1-1","RefSeq","NP_775616.1","29631683","Up-regulation of RIP140 promotes glucolipotoxicity-induced damage in pancreatic beta cells. Publication Status: Online-Only"
> "Q8CBD1-1","RefSeq","NP_775616.1","29233969","RIP140 is a co-repressor of HSF1, and it regulates neuronal stress response. Publication Status: Online-Only"
4241a5753,5755
> "P23249-1","RefSeq","NP_032645.2","28662698","Mov10 is essential for normal neuronal development and brain function. Mov10 preferentially binds RNAs involved in actin binding, neuronal projection, and cytoskeleton. This is a completely new and critically important function for Mov10 in neuronal development. Publication Status: Online-Only"
> "Q8R1P4-1","RefSeq","NP_080046.3","12890687","The isolated mouse APG10 gene product interacts with mammalian Apg12p dependent on mammalian Apg7p (E1-like enzyme), and facilitates Apg12p conjugation."
> "Q8R1P4-1","RefSeq","NP_080046.3","12482611","APG10 has a role in mediating the conjugation of APG12 with APG5"
4247a5762,5771
> "Q4KMM3-1","RefSeq","NP_570955.1","29905912","We present a dysregulation of metabolites of glucose metabolism at the pre-symptomatic stage in the Oxr1 knockout cerebellum. We then demonstrate that Oxr1 and Gpi1 physically and functionally interact and that the level of Gpi1 oligomerisation is disrupted when Oxr1 is deleted in vivo. Furthermore, we show that Oxr1 modulates the additional and less well-understood roles of Gpi1 as a cytokine and neuroprotective factor."
> "Q4KMM3-1","RefSeq","NP_570955.1","27036366","Screening a panel of proteins that regulate mitochondrial morphology in bella GCs revealed de-regulation of phospho-Drp1(Ser616), a key mitochondrial fission regulatory factor. Our data provide new insights into the function of Oxr1, revealing that specific isoforms of this novel antioxidant protein are associated with mitochondria."
> "Q4KMM3-1","RefSeq","NP_570955.1","25753484","Identify OXR1 as the first neuron-specific antioxidant modulator of pathogenesis and disease progression in SOD1-mediated amyotrophic lateral sclerosis"
> "Q8C9B9-1","RefSeq","NP_808520.2","28330622","Embryonic stem cells mainly express DIDO3 and their differentiation after leukemia inhibitory factor withdrawal requires DIDO1 expression. DIDO3 regulates DIDO1 expression."
> "Q8C9B9-1","RefSeq","NP_808520.2","25825751","Data indicate that death inducer-obliterator (dido) mutant mice with high incidence of perinatal lethality and distinct neurodevelopmental, morphogenetic, and metabolic alterations."
> "Q8C9B9-1","RefSeq","NP_808520.2","24667272","Death inducer obliterator (Dido3)-dependent targeting of histone deacetylase 6 (HDAC6) is a key determinant of cilium size in growth-arrested cells Publication Status: Online-Only"
> "Q8C9B9-1","RefSeq","NP_808520.2","24347171","Dido1 is able to regulate self-renewal of mouse embryonic stem cells."
> "Q8C9B9-1","RefSeq","NP_808520.2","19557426","Results indicate that histone H3 lysine 4 demethylation modulates DIDO3 localization in meiosis and suggest epigenetic regulation of the synaptonemal complex"
> "Q8C9B9-1","RefSeq","NP_808520.2","17299043","Dido3, the largest splice variant of the Dido gene, is a centrosome-associated protein whose disruption leads to supernumerary centrosomes, failure to maintain cellular mitotic arrest, and early degradation of the mitotic checkpoint protein BubR1."
> "Q8C9B9-1","RefSeq","NP_808520.2","16127461","Data suggest that Dido might be one of the tumor suppressor genes at chromosome 20q and that the Dido-targeted mouse may be a suitable model for studying myeloproliferative diseases and myelodysplastic syndromes."
4259a5784,5791
> "Q70IV5-1","RefSeq","NP_997546.2","29247678","Synemin plays an important regulatory role in the heart and that the consequences of its absence are profound."
> "Q70IV5-1","RefSeq","NP_997546.2","25567810","Suggest that synemin contributes to linkage between costameres and the contractile apparatus and that the absence of synemin results in decreased fiber size and increased sarcolemmal deformability and susceptibility to injury."
> "Q70IV5-1","RefSeq","NP_997546.2","17654553","Alpha- and beta-synemin transcripts and their encoded proteins colocalize in neurons, especially in the midbrain and pons."
> "Q70IV5-1","RefSeq","NP_997546.2","17356066","Dmn is expressed in reactive astrocytes in neurotrauma and interacts differentially with Vim and Gfap."
> "Q70IV5-1","RefSeq","NP_997546.2","16817202","Synemin gene encodes proteins belonging to the intermediate filament which confer resistance to mechanical stress and modulate cell shape."
> "Q5UKY4-1","RefSeq","NP_083294.2","17982101","CD200R3 functions as an activating receptor on mast cells and basophils to regulate IgE-independent immune responses in cooperation with an inhibitory receptor CD200R"
> "Q5UKY4-1","RefSeq","NP_083294.2","15471863","During parasitic helminth infection, we identified CD200 receptor-like 3 as a transcript highly expressed in basophils and mast cells"
> "Q5UKY4-1","RefSeq","NP_083294.2","14644999","Expression of the immunoregulatory protein CD200 increases as murine dendritic cells undergo apoptosis."
4275a5808,5809
> "Q78ZA7-1","RefSeq","NP_032698.1","23550035","Leukocyte migration is initiated by homotypic adhesive interactions between platelets, leading to the development of an NAP-2 chemotactic gradient within the thrombus body that guides leukocytes to sites of vascular injury."
> "Q78ZA7-1","RefSeq","NP_032698.1","21333655","Results identified several proteins interacting with NAP1L2, including the ubiquitously expressed members of the nucleosome assembly protein family, NAP1L1 and NAP1L4."
4280a5815,5818
> "Q9Z2W1-1","RefSeq","NP_067512.3","29794231","First evidence for a key function of STK25 in controlling the metabolic balance of lipid utilization vs lipid storage in brown and white adipose depots, suggesting that repression of STK25 activity offers a potential strategy for establishing healthier adipose tissue in the context of chronic exposure to dietary lipids."
> "Q9Z2W1-1","RefSeq","NP_067512.3","29930001","STK25 is one of the mediators in the complex molecular network controlling the development of atherosclerosis in hyperlipidemic mice."
> "Q9Z2W1-1","RefSeq","NP_067512.3","27421788","A significant positive correlation in human liver biopsies between STK25 expression and nonalcoholic steatohepatitis development"
> "Q5SWY7-1","RefSeq","NP_848733.2","23656696","Suggest that this mutation in Fam83g is the likely basis of the mouse wooly phenotype Publication Status: Online-Only"
4286a5825,5828
> "P46061-1","RefSeq","NP_035371.4","27717094","Data suggest that remodeling of the RanGAP-mediated nuclear transport system plays a key role in cell cycle exit for terminal differentiation of cortical neurons"
> "P46061-1","RefSeq","NP_035371.4","26304119","Nuclear localization of Ran was strongly increased in MYCBP2-deficient DRGs"
> "P46061-1","RefSeq","NP_035371.4","26321253","Immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 and NF-kappaB p65 nuclear entry in T cells"
> "Q9CXC9-1","RefSeq","NP_076283.2","12871699","ERM is a transcription factor in the ets family, within which it forms the PEA3 group."
4293a5836
> "Q9D7S0-1","RefSeq","NP_081615.2","27027293","Lypd8 prevents flagellated microbiota invading the colonic epithelia in mice; Lypd8 mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis"
4314,4318c5857
< "E9PYI1-1","RefSeq","NP_001028527.2","28522536","A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568"
< "E9PYI1-1","RefSeq","NP_001028527.2","23071813","Zfp568 is both a neural stem cell-maintaining and a brain size-regulating gene."
< "E9PYI1-1","RefSeq","NP_001028527.2","22110054","The results revealed that TRIM28 is differentially required by ZFP568 and other factors during the early stages of mouse embryogenesis."
< "E9PYI1-1","RefSeq","NP_001028527.2","21094155","ZFP568 controls the production of secreted factors required to promote morphogenesis of extraembryonic tissues."
< "E9PYI1-1","RefSeq","NP_001028527.2","18701545","Chato regulates convergent extension in the mouse embryo."
---
> "Q3U1J1-1","RefSeq","NP_076013.1","17041757","Although p53 is a main regulator of apoptosis in mammalian cells, the Tfpt induced apoptosis appears p53-independent."
4323c5862
< "Q8BYK6-1","RefSeq","NP_001139391.1","30591559","Findings uncover the role of YTHDF3 as a negative regulator of antiviral immunity through the translational promotion of FOXO3 mRNA under homeostatic conditions, adding insight into the networks of RNA-binding protein-RNA interactions in homeostatically maintaining host antiviral immune function and preventing inflammatory response."
---
> "O88487-1","RefSeq","NP_034194.1","25015291","SQSTM1 is required for proper dynein motility and trafficking along microtubules."
4330a5870,5871
> "P43081-1","RefSeq","NP_032215.2","29549122","Conclude that, under normal physiological conditions, GCAP1 dominates the regulation of cGMP synthesis in mouse cones, but if its function becomes compromised, GCAP2 contributes to the regulation of phototransduction and light adaptation of cones"
> "P43081-1","RefSeq","NP_032215.2","21464903","Mutant GCAP1, when under normal expression control, causes both rod and cone photoreceptors to lose function and degenerate, with cone cells being more severely affected, in keeping with the human disease phenotype. Publication Status: Online-Only"
4331a5873,5875
> "Q7TQD2-1","RefSeq","NP_878259.1","27506655","The present study provides additional support for roles for TPPP in the etiology of depression following early adversity."
> "Q7TQD2-1","RefSeq","NP_878259.1","19606501","These results support an essential role for TPPP/p25 in oligodendrocyte differentiation likely via rearrangement of the microtubule system during the process elongation prior to the onset of myelination."
> "Q7TQD2-1","RefSeq","NP_878259.1","18028908","LIMK1 phosphorylation of p25 blocks p25 activity, thus promoting microtubule disassembly."
4334a5879,5880
> "Q3UUJ4-1","RefSeq","NP_082402.1","21903876","Quantitative PCR revealed significantly reduced LKB1, MO25alpha, and STRADbeta mRNA in LKB1(-/-) muscle. These findings demonstrate that the LKB1-MO25-STRAD complex is the principal AMPKK in skeletal muscle."
> "Q3UUJ4-1","RefSeq","NP_082402.1","20424326","Aberrant nuclear accumulation of LKB1 caused by STRADalpha deficiency contributes to hyperactivation of mTORC1 signaling and disruption of neuronal lamination during corticogenesis"
4336a5883,5886
> "Q9DC40-1","RefSeq","NP_082156.2","31323273","Upregulating Tel2 expression increases mTOR-mediated cardiomyocyte survival and targeting Tel2 could be another therapeutic strategy against ischemic heart disease"
> "Q9DC40-1","RefSeq","NP_082156.2","24657168","IP7, formed by IP6K2, binds CK2 to enhance its phosphorylation of the Tti1/Tel2 complex, thereby stabilizing DNA-PKcs and ATM. This process stimulates p53 phosphorylation at serine 15 to activate the cell death program."
> "Q9DC40-1","RefSeq","NP_082156.2","20864032","The CK2 phospho-dependent interaction between TEL2 and the R2TP complex affects phosphatidylinositol 3-kinase-related kinase functions and is essential for mTOR and SMG1 stability in vivo."
> "Q9DC40-1","RefSeq","NP_082156.2","18160036","Identify Tel2 as a highly conserved regulator of the stability of PI3K-related protein kinases."
4350a5901
> "Q8BNE1-1","RefSeq","NP_084206.1","25559186","Report novel TRP channel-associated factors that modulate TRPM8 activity."
4367,4371d5917
< "Q62406-1","RefSeq","NP_001171445.1","30391544","Pharmacological inhibition or siRNA mediated knockdown of IRAK1/4 attenuated Nod1-mediated activation of NF-kappaB, JNK, and the expression of proinflammatory cytokines. These results reveal that Nod1-mediated lipolysis promoted accumulation of DAG, which engaged PKCdelta and IRAK1/4 to augment inflammation in 3T3-L1 adipocytes."
< "Q62406-1","RefSeq","NP_001171445.1","30361091","IRAK1 is one of the critical components involved in podocyte apoptosis in Diabetic nephropathy."
< "Q62406-1","RefSeq","NP_001171445.1","30078230","Findings demonstrate that the pro- and anti-inflammatory responses to gAd in innate immune cells are time-dependent, and mediated by the activation of the IkappaB/NF-kappaB pathway, and IRAK-1 downregulation, respectively."
< "Q62406-1","RefSeq","NP_001171445.1","29995830","Suppression of inflammatory responses and T cells apoptosis were observed with elevated expression of IRAK-M and PDL-1, and interference and neutralization of these 2 molecules led to partly reversed suppression of inflammation. Publication Status: Online-Only"
< "Q62406-1","RefSeq","NP_001171445.1","29804558","The expression of IL-1 receptor-associated kinase 1 (IRAK1) that regulates NF-kappaB, p38, and the JNK signaling pathways, was also increased by MPQP."
4381a5928,5933
> "Q6PHB0-1","RefSeq","NP_766374.1","23811545","IL-20R1 and IL-20R2 are constitutively express in the brain."
> "Q6PHB0-1","RefSeq","NP_766374.1","19078987","MIL-20R1a functioned as an aggravating factor in promoting calcium deposition in kidney of mice."
> "E9Q492-1","RefSeq","NP_001156392.1","24928388","Thus SB and PB transposons represent a promising non-viral approach for iPS cell derivation."
> "Q9JIL6-1","RefSeq","NP_444348.1","15086536","GPRC5D is involed in the regulation of keratin synthesis in hard epithelial tissue."
> "P51908-1","RefSeq","NP_112436.1","29167375","APOBEC1-mediated RNA editing occurs within brain microglia cells and is key to maintaining their resting status.  Apobec1-/- mice display age-related signs of CNS neurodegeneration."
> "P51908-1","RefSeq","NP_112436.1","28069890","The observations demonstrate that A1CF does not act as the APOBEC1 complementation factor in vivo under normal physiological conditions and suggest new roles for A1CF, specifically within the male adult kidney."
4389a5942,5945
> "Q812B2-1","RefSeq","NP_783575.2","26018249","Expressed in newborn skulls and long bones but declined rapidly thereafter Erratum:[Endocrinology. 2018 Apr 1;159(4):1762. PMID: 29529189]"
> "Q812B2-1","RefSeq","NP_783575.2","25117405","Lacking GPB5 during acute illness does not affect the LPS-induced decrease of serum thyroid hormones Erratum:[Am J Physiol Endocrinol Metab. 2014 Nov 1;307(9):E856. Duncan Bassett, J H [corrected to Bassett, J H Duncan]]"
> "Q812B2-1","RefSeq","NP_783575.2","21314737","Results demonstrate in vivo regulation of central GPB5 transcription during acute illness."
> "Q812B2-1","RefSeq","NP_783575.2","15699348","When GPB5-TG mice are challenged with a high-fat diet, they gain significantly less weight and body fat than their WT littermates"
4412a5969,5971
> "Q61616-1","RefSeq","NP_034206.1","29803941","Results suggest that the activation of the dopamine D1 receptor plays a critical role in the persistence of long-term spatial memory through the PKA signaling pathway."
> "Q61616-1","RefSeq","NP_034206.1","29847232","Study found that D1 receptor activation reduced the amplitude of electrically evoked responses, showing that D1 receptors can modulate amacrine cells directly. Results suggest that D1 receptor activation can replicate a large portion but not all of the effects of light adaptation, likely by modulating release from amacrine cells onto rod bipolar cells."
> "Q61419-1","RefSeq","NP_031743.3","29196263","These findings have the potential to significantly advance our understanding of how this enigmatic tumor-associated antigen is produced in humans, and also suggest a possible mechanism of action of anti-tumor antibodies that recognize hypoxia markers, such as 14F7."
4415a5975
> "A0A0A6YY25-1","RefSeq","NP_001138572.1","28292424","BTBD18 is a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA loci."
4416a5977,5980
> "P12657-1","RefSeq","NP_031724.2","29915209","This study demonstrates that TRPC4 channels are involved in spontaneous and cholinergic-mediated contractions of the murine detrusor. Publication Status: Online-Only"
> "P12657-1","RefSeq","NP_031724.2","29424434","This study revealed that almost all PV neuronal somata expressed M1R and some strocytes showed substantial M1R immunopositivity signals."
> "Q923T7-1","RefSeq","NP_444396.2","30928727","TRIM7 may facilitate the TLR4-mediated innate response via its E3 ligase domain in macrophages."
> "Q923T7-1","RefSeq","NP_444396.2","29466708","GNIP1 is an ubiquitin ligase with a markedly glycogenic effect in skeletal muscle."
4418,4424c5982,5983
< "Q80U23-1","RefSeq","NP_001278005.1","28891816","SNPH is a stress-regulated mitochondrial switch of the cell proliferation-motility balance in cancer, and its pathway may represent a therapeutic target."
< "Q80U23-1","RefSeq","NP_001278005.1","28472658","Stressed mitochondria are removed from axons triggered by the bulk release of mitochondrial anchoring protein syntaphilin via a new class of mitochondria-derived cargos independent of Parkin, Drp1, and autophagy."
< "Q80U23-1","RefSeq","NP_001278005.1","27370822","DISC1 in association with SNPH is a component of a modulatory complex that determines mitochondrial anchoring in response to neuronal activation. Publication Status: Online-Only"
< "Q80U23-1","RefSeq","NP_001278005.1","25834054","SNPH deletion produces striking benefits in the Shiverer mouse by prolonging survival, reducing cerebellar damage, suppressing oxidative stress, and improving itochondrial health. Erratum:[J Neurosci. 2015 Aug 12;35(32):11458]"
< "Q80U23-1","RefSeq","NP_001278005.1","23857772","SNPH is required for activity-dependent regulation of mitochondrial transport."
< "Q80U23-1","RefSeq","NP_001278005.1","19641106","Our studies suggest an unexpected role for LC8 and provide new mechanistic insights into how SNPH and LC8 together immobilize mitochondria through a dynamic interaction between the docking receptor and axonal cytoskeleton."
< "Q80U23-1","RefSeq","NP_001278005.1","18191227","Here, we report a role for axon-targeted syntaphilin (SNPH) in mitochondrial docking through its interaction with microtubules. Axonal mitochondria that contain exogenously or endogenously expressed SNPH lose mobility."
---
> "O09126-1","RefSeq","NP_038688.2","29981480","Sema4D induces the clustering of inhibitory presynaptic components via Plexin-B1."
> "O09126-1","RefSeq","NP_038688.2","29618514","Suggest that STING activates ADAM17 and that this activation produces soluble proinflammatory SEMA4D independently of the TBK1/IRF3-mediated transcriptional pathway"
4428a5988,5990
> "Q60769-1","RefSeq","NP_033423.3","31086261","Single-cell imaging revealed that RIPK3-dependent death caused inflammasome-dependent IL-1beta release from lipopolysaccharide-stimulated A20-deficient macrophages. Importantly, mutation of the A20 ZnF7 ubiquitin binding domain caused arthritis in mice, arguing that ZnF7-dependent inhibition of necroptosis is critical for A20 anti-inflammatory function in vivo."
> "Q60769-1","RefSeq","NP_033423.3","31015422","Study data show that the anti-inflammatory protein A20 and the critical autophagic mediator Atg16l1 physically interact and synergize to regulate the stability of the intestinal epithelial barrier. Collectively data show that A20 and Atg16l1 cooperatively control intestinal homeostasis by acting at the intersection of inflammatory, autophagy and cell death pathways. Publication Status: Online-Only"
> "Q60769-1","RefSeq","NP_033423.3","30209212","A20 dimers bind linear ubiquitin to stabilize the Ripoptosome and potentiate its apoptosis-inducing activity."
4429a5992,5995
> "A2AT37-1","RefSeq","NP_001074601.1","27149259","We report that UPF2-mediated nonsense-mediated mRNA decay (NMD) plays an essential role in male germ cells by eliminating ubiquitous genes-derived, longer 3'UTR transcripts, and that this role is independent of its canonical role in degrading 'premature termination codon' (PTC)-containing transcripts in somatic cell lineages Publication Status: Online-Only"
> "A2AT37-1","RefSeq","NP_001074601.1","27149095","Upon removal of TDRD6, the association of several mRNAs with UPF1 and UPF2 is disturbed, and the long 3' UTR-stimulated but not the downstream exon-exon junction triggered pathway of NMD is impaired.This function depends on TDRD6-promoted assembly of mRNA and decay enzymes in Chromatoid bodies . Publication Status: Online-Only"
> "A2AT37-1","RefSeq","NP_001074601.1","20657840","Study find that loss of Upf2 during fetal liver development is incompatible with postnatal life due to failure of terminal differentiation. Moreover, deletion of Upf2 in the adult liver results in hepatosteatosis and disruption of liver homeostasis. Publication Status: Online-Only"
> "A2AT37-1","RefSeq","NP_001074601.1","18483223","Hematopoietic-specific deletion of Upf2, a core NMD factor, led to the rapid, complete, and lasting cell-autonomous extinction of all hematopoietic stem and progenitor populations."
4435a6002,6003
> "Q64151-1","RefSeq","NP_001291259.1","28467912","Follicular T helper cells use Semaphorin 4C as a guidance receptor to sense germinal center-expressed Plexin B2."
> "Q64151-1","RefSeq","NP_001291259.1","27881703","We demonstrate that Sema4C is critical for optimal regulatory cytokine production in CD138(+) B cells."
4442a6011,6020
> "Q149L7-1","RefSeq","NP_062338.3","26694968","These results reveal that CRTAM is critical to instruct the differentiation of CD4(+)CTL through the induction of Eomes and CTL-related gene."
> "Q149L7-1","RefSeq","NP_062338.3","24687959","During pathogenic infection, Crtam-Cadm1 interactions regulate the dynamic equilibrium between newly formed CD4(+) T cells and their retention in the gut."
> "Q149L7-1","RefSeq","NP_062338.3","21572449","TCS upregulated the expression of tumor suppressor in lung cancer 1 (TSLC1) in 3LL tumor cells and the expression of its ligand, class I-restricted T cell-associated molecule (CRTAM), in effector T cells."
> "Q149L7-1","RefSeq","NP_062338.3","15811952","NK cells and T8 cells recognize Necl-2 through CRTAM, expressed only on activated cells. CRTAM-Necl-2 interactions promote cytotoxicity of NK cells and IFN-gamma secretion of T8 cells as well as NK cell-mediated rejection of tumors expressing Necl-2"
> "Q149L7-1","RefSeq","NP_062338.3","15781451","Necl2/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system"
> "P70274-1","RefSeq","NP_033181.3","29636330","Selenoprotein P promotes the development of pulmonary hypertension by stimulating excessive proliferation and apoptosis resistance of pulmonary artery smooth muscle cells."
> "P70274-1","RefSeq","NP_033181.3","29547524","In this study, the role of SeP in ischemia/reperfusion (I/R) injury has been investigated. Publication Status: Online-Only"
> "P70274-1","RefSeq","NP_033181.3","29069514","Results indicate a diversity of RNA elements conducting multiple occurrences of UGA redefinition to control the synthesis of full-length and truncated selenoprotein P (SELENOP) isoforms."
> "P70274-1","RefSeq","NP_033181.3","28263310","SeP causes exercise resistance through its muscle receptor low-density lipoprotein receptor-related protein 1 (LRP1). SeP-deficient mice showed a 'super-endurance' phenotype after exercise training, as well as enhanced reactive oxygen species production, AMPK phosphorylation and Ppargc-1alpha expression in skeletal muscle."
> "P70274-1","RefSeq","NP_033181.3","23064117","Results emphasize the importance of non-coding transcript variations as a regulatory means for Sepp1 expression in different tissues and stages of development; presence of a variant localized in the hippocampus and regulated by a microRNA may have implications for deficits in synaptic function caused by genetic deletion of Sepp1"
4456c6034,6039
< "P0DOV1-1","RefSeq","NP_001028622.1","23145002","The role of Mnda in response to apoptosis and genotoxic stress is discussed."
---
> "Q80WQ9-1","RefSeq","NP_852077.1","22693546","Structural and functional properties of Zbed4"
> "Q80WQ9-1","RefSeq","NP_852077.1","21850176","The patterns of spatial and temporal expression of Zbed4 in the mouse retina suggest a possible involvement of this protein in retinal morphogenesis and Muller cell function."
> "O70176-1","RefSeq","NP_033755.1","29969146","Gene expression of PACAP-27 is stimulated across the thalamic paraventricular nucleus following alcohol drinking."
> "O70176-1","RefSeq","NP_033755.1","30150589","Results show that lack of pituitary adenylate cyclase-activating polypeptide (PACAP) influences molecular and biomechanical properties of bone matrix, activating various signalling cascade changes in a compensatory fashion. Publication Status: Online-Only"
> "Q8BKT8-1","RefSeq","NP_996987.1","23182369","Data suggest Uchl5ip has role in spindle formation in oocyte meiotic maturation; Uchl5ip protein level is consistent during metaphase I/II; Uchl5ip localizes to meiotic spindle; loss of Uchl5ip disrupts localization of gamma-tubulin to spindle poles."
> "P83917-1","RefSeq","NP_031648.1","26415775","We demonstrate an unexpected duality in the role of HP1b: it is essential in ESCs for maintaining pluripotency, while it is required for proper differentiation in differentiated cells. Publication Status: Online-Only"
4462a6046
> "A2ABV5-1","RefSeq","NP_036135.3","20194623","MED14 constitutes a novel anchoring point between Mediator and the N-terminal domain of PPARgamma that is necessary for functional PPARgamma-mediated recruitment of Mediator and transactivation of PPARgamma subtype-specific target genes."
4466,4467c6050,6063
< "Q9QWH1-1","RefSeq","NP_001182059.1","24091011","Polymerization of the Phc2 SAM domain is required for PRC1 clustering, chromatin condensation and gene silencing."
< "Q9QWH1-1","RefSeq","NP_001182059.1","23605804","Phc2 may act as a negative regulator that inhibits the activity of Th cells."
---
> "Q8K4N2-1","RefSeq","NP_694755.1","23815807","Data suggest that Spag11a has a specific role in epididymal sperm maturation. Publication Status: Online-Only"
> "Q8K4N2-1","RefSeq","NP_694755.1","22535201","Model was developed in which Bin1b was exclusively overexpressed by up to 50-fold in the caput epididymis. The transgenic mice are healthy with normal reproductive activity, but are more resistant to epididymal infection from E coli than normal animals."
> "Q8K4N2-1","RefSeq","NP_694755.1","21199063","Increased expression in response to lipopolysaccharide administration"
> "Q8K4N2-1","RefSeq","NP_694755.1","12193721","The epididymis-specific expression pattern of the beta-defensin isoform EP2e has been characterized."
> "O35717-1","RefSeq","NP_031732.1","29881947","Our data suggest a novel role for SOCS2 in interacting with and regulating the trafficking of TrkB, leading to increased neurite outgrowth in hippocampus neurons."
> "O35717-1","RefSeq","NP_031732.1","29343614","The absence of SOCS2 is protective against bone loss typical of inflammatory bowel disease. Publication Status: Online-Only"
> "Q9R1S0-1","RefSeq","NP_038745.1","21763481","B9d1 is required for normal Hh signaling, ciliogenesis, and ciliary protein localization. B9d1 and B9d2 are essential components of a B9 protein complex, disruption of which causes Meckel syndrome. Erratum:[Am J Hum Genet. 2011 Oct 7;89(4):589. Zaghloul, Norran A [corrected to Zaghloul, Norann A]]"
> "P31750-1","RefSeq","NP_033782.1","31336140","Present study highlighted that overexpression of miR-203 may function as a cardioprotective regulator in DCM by targeting PIK3CA via inactivation of PI3K/Akt signaling pathway."
> "P31750-1","RefSeq","NP_033782.1","31421084","MAT1 serves as a promoter in the lung metastasis of osteosarcoma through increasing AKT1 expression."
> "P31750-1","RefSeq","NP_033782.1","30999647","The in vivo results revealed that DHL significantly attenuated LPS-induced pathological injury and reduced cytokines expression in the lung. NF-kappaB, p38 MAPK/MK2 and Akt signaling molecules were also involved in the anti-inflammatory effect. Publication Status: Online-Only"
> "P31750-1","RefSeq","NP_033782.1","31061823","These data suggest that FAK/PI3K/Akt signaling pathway and MMP-2 and MMP-9 may be involved in the development of Herpes Simplex Keratitis. Publication Status: Online-Only"
> "E9QAN8-1","RefSeq","NP_001092746.2","27548528","Pik3c2b is a genetic modifier of Mtm1 mutation with a role in function and survival in myotubular myopathy animal models"
> "E9QAN8-1","RefSeq","NP_001092746.2","26820527","Modulation of PKA and PI3KC2beta activity to control of KCa3.1 channel expression can be an alternative important target to attenuate ascending thoracic aortic aneurysms in Fabry disease."
> "E9QAN8-1","RefSeq","NP_001092746.2","16222711","Our findings demonstrate for the first time that the PI3K-C2beta isoform associates with clathrin and thus provides a link between receptor mediated intracellular signalling and clathrin coated vesicle transport."
4469a6066,6070
> "G3X939-1","RefSeq","NP_001074529.1","30956978","An association between congenital bilateral absence of the vas deferens (CBAVD) and loss of SLC9A3 and propose that specific defects in the reproductive duct due to SLC9A3 variants drive CBAVD development. Publication Status: Online-Only"
> "G3X939-1","RefSeq","NP_001074529.1","30571224","Our results support the scientific premise and physiological relevance that NHE3 in the proximal tubules plays an essential role in maintaining basal blood pressure homeostasis, and genetic deletion of NHE3 selectively in the proximal tubules of the kidney lowers blood pressure by increasing the pressure natriuretic response."
> "G3X939-1","RefSeq","NP_001074529.1","29167115","Intestinal NHE3 gene expression is regulated by changes in its DNA methylation."
> "G3X939-1","RefSeq","NP_001074529.1","28882822","NHERF2 and NHERF3 have overlapping roles in NHE3 stimulation by LPA and inhibition by elevated Ca(2+) and cGMP."
> "G3X939-1","RefSeq","NP_001074529.1","29286340","The data indicate that SLC9A3 has a vital role in acrosomal formation during spermatogenesis. Publication Status: Online-Only"
4471a6073
> "Q5F293-1","RefSeq","NP_083624.2","27815388","We provide genetic evidence that the wild-type H-Ras and K-Ras proteins are bioequivalent in spite of their different structural and biological properties"
4476,4481c6078,6082
< "Q8CJ53-1","RefSeq","NP_001229318.1","28720386","CIP4 silencing can efficiently alleviate Streptozotocin-induced pulmonary fibrosis in mice, perhaps through suppressing Wnt/GSK-3beta/beta-catenin signaling."
< "Q8CJ53-1","RefSeq","NP_001229318.1","23881916","CIP4 is a new component in the highly coordinated system of megakaryocytic membrane and cytoskeletal remodeling affecting platelet production."
< "Q8CJ53-1","RefSeq","NP_001229318.1","23572514","CIP4 coordinates with phospholipids and actin-associated proteins to localize to the protruding edge and produce actin ribs and veils."
< "Q8CJ53-1","RefSeq","NP_001229318.1","22920438","Data suggest that down-regulation of CIP4 in osteosarcoma changes cell morphology (reduces actin; alters cytoskeleton), inhibits primary tumor growth, impairs invasiveness and migration of tumor cells, delays metastasis, and prolongs survival time."
< "Q8CJ53-1","RefSeq","NP_001229318.1","22361215","In primary cortical neurons CIP4 is concentrated specifically at the tips of extending lamellipodia and filopodia, instead of endosomes as in other cell types."
< "Q8CJ53-1","RefSeq","NP_001229318.1","12054674","Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms (CIP4)"
---
> "Q9JIL4-1","RefSeq","NP_067492.2","29405165","Pdzk1, which plays a critical role in cholesterol metabolism and carnitine transport, was found in sperm lipid metabolism. Western blotting and immunofluorescence analyses showed that Pdzk1 was expressed in the epididymis but not in the testis, and localized at the middle piece of the sperm tail."
> "Q9JIL4-1","RefSeq","NP_067492.2","29305867","These results suggest that the PDZ domain of PICK1 directly interacts with calcineurin B in osteoclast progenitor cells and promotes osteoclast differentiation through activation of calcineurin-NFAT signaling."
> "Q9JIL4-1","RefSeq","NP_067492.2","28882822","NHERF2 and NHERF3 have overlapping roles in NHE3 stimulation by LPA and inhibition by elevated Ca(2+) and cGMP."
> "Q9JIL4-1","RefSeq","NP_067492.2","28754554","Dysfunction of intestinal OCTN1 in mouse model of chronic kidney disease (CKD) impaired the OCTN1-ergothioneine axis, an adaptive antioxidant system, and that decreased antioxidant ergothioneine levels may contribute to CKD progression in a PDZK1-dependent manner."
> "Q9JIL4-1","RefSeq","NP_067492.2","12556478","While PDZK1-deficient mice developed normally, did not display any gross phenotypic abnormalities, and were fecund, lack of PDZK1 resulted in modulation of expression of selective ion channels in the kidney, as well as increased serum cholesterol levels."
4486,4487d6086
< "O88879-1","RefSeq","NP_001036023.1","29596528","Data collectively demonstrated that Apaf1 is a negative regulator of T cell responses and implicated Apaf1 as a potential target for immunosuppressive drug discovery Publication Status: Online-Only"
< "O88879-1","RefSeq","NP_001036023.1","27580417","MiR-183 was induced in protective postconditioning and reduced reperfusion injury of the livers via the targeting of apoptotic signaling. miR-183 mediated the tolerance induced by iPoC in livers via Apaf-1 repressing."
4490a6090,6092
> "Q8BPP5-1","RefSeq","NP_796113.1","29195920","Study employ the marble burying (MB) and elevated zero maze (EZM) tests in Lypd6 knock-out (KO) and wild-type (WT) mice and find that loss of Lypd6 leads to decreased digging behaviour in the MB test and increased time spent in the open area in the EZM test; demonstrate that acute nicotine administration reduces digging in the MB test in both KO and WT mice and further accentuates the inherent genotype difference."
> "Q8BPP5-1","RefSeq","NP_796113.1","23987510","Lypd6 appears to control Lrp6 activation specifically in membrane rafts, which is essential for downstream signaling."
> "Q8BPP5-1","RefSeq","NP_796113.1","19403274","Lypd6 seems to constitute a novel modulator of nAChRs that affects receptor function by selectively increasing Ca2+-influx through ion channels"
4493a6096
> "Q920M5-1","RefSeq","NP_624356.1","24523531","These findings demonstrate that Coronin 6 is a critical regulator of AChR clustering at the postsynaptic region of the neuromuscular junction"
4496a6100,6101
> "Q91YM2-1","RefSeq","NP_766327.3","26859289","P190A acts as a modulator of Rho GTPases in a localized area around the cilia to permit the dynamic actin rearrangement required for cilia elongation. Publication Status: Online-Only"
> "Q91YM2-1","RefSeq","NP_766327.3","23499677","The cellular RacGAP activity of p190RhoGAP requires an intact polybasic region adjacent to the GAP domain whereas the RhoGAP activity is inhibited by the same domain."
4499a6105,6106
> "Q8K2F3-1","RefSeq","NP_666092.1","29702025","Hepatic overexpression of DEPP in mice promotes fatty acid oxidation and ketogenesis and suppresses lipogenesis and gluconeogenesis, which is partly mediated by FGF21 induced by elevated cellular ROS levels."
> "Q8K2F3-1","RefSeq","NP_666092.1","19937567","DEPP is a novel insulin-regulatory molecule expressed abundantly in insulin-sensitive tissues including white adipose tissue and liver."
4502a6110,6111
> "Q8VHS6-1","RefSeq","NP_543123.2","18641171","ASB15 has a role in early myoblast differentiation and that its effects may be mediated in part by the PI3K/Akt signal transduction pathway"
> "Q8VHS6-1","RefSeq","NP_543123.2","16424087","Results suggest ASB15 participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells."
4504a6114,6116
> "P26043-1","RefSeq","NP_033067.2","29906485","The results showed that Among designated developmental stages, RDX has highest fold difference in early embryonic and postnatal stages."
> "P26043-1","RefSeq","NP_033067.2","28893864","LRBA deficiency is associated with a reduced abundance of radixin and Nherf2, two adaptor proteins, which are important for the mechanical stability of the basal taper region of stereocilia."
> "P26043-1","RefSeq","NP_033067.2","28302370","Inactivation of SHIP2 leads to increased microvilli formation and solute reabsorption by the renal proximal tubule and was associated with hyperactivated ezrin/radixin/moesin proteins and increased Rho-GTP."
4506a6119
> "P61205-1","RefSeq","NP_031504.1","26067373","Activated ARF3 is associated with Unc93B1 and TLR9, suggesting that ARF3 conducts TLR9 trafficking by forming the TLR9-Unc93B1-ARF3 complex."
4511,4513c6124,6129
< "Q60631-1","RefSeq","NP_001300865.1","30183074","GRB2 inhibitors may have the potential to dampen tissue eosinophilia in various eosinophil-associated diseases."
< "Q60631-1","RefSeq","NP_001300865.1","28964849","Our findings position Grb2 as a key adaptor that integrates various cytokines response in cycling Hematopoietic Stem and Progenitor Cell ."
< "Q60631-1","RefSeq","NP_001300865.1","28455498","Study shows that growth factor receptor binding protein 2 carboxyl-terminal SH3 domain can bivalently associate with two ligands, in an SH3 dependent manner. Extrapolating the results of this study to the in vivo conditions, Grb2 should bind the SLP65 transducer module first, and then Vav should associate. Publication Status: Online-Only"
---
> "A1E960-1","RefSeq","NP_081404.2","28436474","Data suggest that amelotin (AMTN), odontogenic ameloblast-associated protein (ODAM) and secretory calcium-binding phosphoprotein proline-glutamine rich 1 (SCPPPQ1) participate in structuring an extracellular matrix with the distinctive capacity of attaching epithelial cells to mineralized surfaces. Publication Status: Online-Only"
> "A1E960-1","RefSeq","NP_081404.2","22213140","The BMP-2-BMPR-IB-ODAM-MAPK signaling cascade has important roles in ameloblast differentiation and enamel mineralization"
> "A1E960-1","RefSeq","NP_081404.2","22387195","We propose that ODAM has diverse functions that vary with protein location in various cell lines. Nuclear ODAM appears to be associated with MMP-20 regulation and tumorigenesis. Additional functions may take place in cytoplasm and extracellular matrix."
> "A1E960-1","RefSeq","NP_081404.2","22231912","ODAM and AMTN are bona fide components of the basal lamina associated with maturation stage ameloblasts and they organize into different subdomains during the early maturation stage."
> "A1E960-1","RefSeq","NP_081404.2","20665536","Runx2 regulates the expression of ODAM and nuclear ODAM serves an important regulatory function in the mineralization of enamel through the regulation of MMP-20 apart from a different, currently unidentified, function of extracellular ODAM."
> "A1E960-1","RefSeq","NP_081404.2","17647262","The protein sequences deduced from the cloned cDNA for rat, mouse, pig, and human were aligned together with those obtained from four other mammal genomes. Apin is highly conserved in mammals."
4527a6144,6145
> "P55098-1","RefSeq","NP_033020.2","27597759","PEX2 is required for peroxisome autophagy during starvation."
> "P55098-1","RefSeq","NP_033020.2","22441164","Data indicate that the induction of SREBP-2 and ER stress pathways is independent of PPARalpha activation in livers of newborn peroxisome assembly factor 1 (Pex2) knockout mice."
4529a6148,6150
> "Q8CFX1-1","RefSeq","NP_775547.2","29568102","Studied expression levels and signal pathways involved with hexose-6-phosphate dehydrogenase in mouse model of diet induced visceral adiposity."
> "Q8CFX1-1","RefSeq","NP_775547.2","28749080","We envisage these data and models finding utility when investigating the muscle-specific functions of the 11beta-HSD1/G6PT/H6PDH triad."
> "Q8CFX1-1","RefSeq","NP_775547.2","24759003","Data suggest that Gh (growth hormone) represses H6pd through locally produced Igf1 (insulin-like growth factor 1); Gh directly represses Hsd11b1 (11-beta-hydroxysteroid dehydrogenase 1) mRNA rather than acting via Igf1 receptor."
4549a6171,6173
> "P49650-1","RefSeq","NP_032798.1","29651133","We analyzed the presence and clearance of TAM and its metabolites (N-desmethyl-tamoxifen, 4-hydroxytamoxifen and endoxifen) in brain and serum of mice by liquid chromatographic-high resolution-tandem mass spectrometry (LC-HR-MS/MS) and assessed optimal injection protocols by quantitative RT-PCR of several floxed target genes (p2ry1, gria1, gabbr1 and Rosa26-tdTomato locus). Publication Status: Online-Only"
> "P49650-1","RefSeq","NP_032798.1","29305530","We found that overexpression of P2Y1 receptors in astrocytes did not increase microdomain Ca(2+) signals in astrocyte processes but caused Ca(2+) wavelike signals"
> "P49650-1","RefSeq","NP_032798.1","29384476","Here, the authors provide genetic evidence that activity-induced calcium accumulation in neonatal terminal/perisynaptic Schwann cells is mediated exclusively by one subtype of metabotropic purinergic receptor, P2ry1. Publication Status: Online-Only"
4552a6177,6180
> "Q9R097-1","RefSeq","NP_058603.2","30193734","Grhl2 regulation of SPINT1 expression controls salivary gland development"
> "Q9R097-1","RefSeq","NP_058603.2","27612426","Results suggest that insufficient hepatocyte growth factor activator inhibitor type 1 (HAI-1) function promotes intestinal carcinogenesis by activating nuclear factor-kappaB (NF-kappaB) signaling."
> "Q9R097-1","RefSeq","NP_058603.2","27189939","By completing our structural characterization of the previously unknown N-terminal region of HAI-1, we provide new insight into the interplay between tertiary structure and the inhibitory activity of a multidomain protease inhibitor"
> "Q9R097-1","RefSeq","NP_058603.2","15964823","HAI-1 is required for branching morphogenesis in the chorioallantoic placenta."
4554a6183,6186
> "G5E829-1","RefSeq","NP_080758.1","29950683","The ATP2B1 gene is important for not only intra-cellular calcium regulation but also for calcium homeostasis and blood pressure control."
> "G5E829-1","RefSeq","NP_080758.1","29046519","Increased intracellular calcium concentration in vascular smooth muscle cells due to lack of ATP2B1 and subsequent activation of L-type calcium channels mainly affects blood pressure and suggests increased susceptibility to calcium channel blockers"
> "G5E829-1","RefSeq","NP_080758.1","29023784","PMCA1 is required for maintaining atrial Ca(2+) homeostasis and electrical stability."
> "G5E829-1","RefSeq","NP_080758.1","28795531","Decreased expression of PMCA1 is associated with increased blood pressure when combined with advancing age."
4564a6197
> "Q8BL97-1","RefSeq","NP_666195.1","16249178","9G8 binds to an element in exon 3 and strongly enhances the excision of GnRH intron A in the presence of minimal amount of other nuclear components"
4568,4574c6201,6204
< "Q9EPK2-1","RefSeq","NP_001277572.1","26936825","This study identifies ARL3 as a key player in prenylated protein trafficking in rod photoreceptor cells and establishes the potential role for ARL3 dysregulation in the pathogenesis of RP2-related forms of X-linked retinitis pigmentosa"
< "Q9EPK2-1","RefSeq","NP_001277572.1","26358772","We first performed detailed characterization of the Rp2-knockout (Rp2-KO) mice and observed early-onset cone dysfunction"
< "Q9EPK2-1","RefSeq","NP_001277572.1","26383048","RP2 has a role in cone photoreceptor sensory cilium elongation in mice"
< "Q9EPK2-1","RefSeq","NP_001277572.1","23745007","Our studies suggest that RP2 contributes to the maintenance of photoreceptor function and that cone opsin mislocalization represents an early step in XLRP caused by RP2 mutations. Publication Status: Online-Only"
< "Q9EPK2-1","RefSeq","NP_001277572.1","20106869","We propose that RP2 regulation of Arl3 is important for maintaining Golgi cohesion, facilitating the transport and docking of vesicles and thereby carrying proteins to the base of the photoreceptor connecting cilium for transport to the outer segment."
< "Q3U285-1","RefSeq","NP_001156545.1","25366156","These findings suggest that transactivation activities of Mlr1 and Mlr2 are differentially regulated by splicing variants of NOL4, which are expressed in a tissue-selective manner."
< "Q3U285-1","RefSeq","NP_001156545.1","12560079","Identification and characterization of Mlr2 a homolog of Mblk-1, a transcription factor from the honeybee brain; expressed predominantly in the spermatocytes of the testis"
---
> "O89112-1","RefSeq","NP_067270.1","28106097","Very similar concentrations of lanthionine ketimine (0.5-2.5 nmol/g tissue) were found in LanCL1 knock-out, LanCL1/LanCL2/LanCL3 triple-knock-out and wild type (WT) mouse brains, suggesting that LanCL proteins are not involved in lanthionine biosynthesis. Publication Status: Online-Only"
> "O89112-1","RefSeq","NP_067270.1","25158856","Loss of LanCL1 causes progressive oxidative damage and neuronal death.  LanCL1 transgene protects neurons from oxidative stress."
> "O89112-1","RefSeq","NP_067270.1","22891245","Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine beta-synthase: a target for neuronal antioxidant defense."
> "O89112-1","RefSeq","NP_067270.1","14514412","LanC-like protein 1 expression in rat testes was initiated already in pachytene spermatocytes in stage IX, but otherwise similar to mouse."
4575a6206,6209
> "O88559-1","RefSeq","NP_032609.1","30315824","Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia."
> "O88559-1","RefSeq","NP_032609.1","30099020","Results showed that the MEN1 gene was negatively correlated with lung fibrinogen markers and provide evidence that MEN1 plays a key role in the formation of pulmonary fibrosis by regulating the secretion of TGF-beta and the activation of TGF-beta/Smads signaling pathway."
> "O88559-1","RefSeq","NP_032609.1","30220511","A distinct astroglial role for menin was identified in regulation of neuroinflammation in depression."
> "O88559-1","RefSeq","NP_032609.1","30120246","Menin maintains the T-cell functions by limiting mTORC 1 activity and subsequent cellular metabolism. Publication Status: Online-Only"
4582a6217,6222
> "Q9WV54-1","RefSeq","NP_062708.1","30472209","Asah1(P361R/P361R) mice exhibit progressive retinal and optic nerve pathology. Through noninvasive ocular imaging and histopathological analyses of these Asah1(P361R/P361R) animals, we revealed progressive inflammation, the presence of retinal dysplasia, and significant storage pathology in various cell types in both the retina and optic nerves."
> "Q9WV54-1","RefSeq","NP_062708.1","30077007","Results suggest that acid ceramidase products within podocytes have inhibitory effects on the Panx1 channel activity."
> "Q9WV54-1","RefSeq","NP_062708.1","29259036","Results demonstrate a tissue-specific role for AC in regulating neutrophilic inflammation and cytokine production."
> "Q9WV54-1","RefSeq","NP_062708.1","29167126","Low ASAH1 expression is associated with Chronic lung injury."
> "Q9WV54-1","RefSeq","NP_062708.1","12815059","Biochemistry of acid ceramidase reaction with acid sphingomyelinase"
> "Q9WV54-1","RefSeq","NP_062708.1","11829492","Mutagenesis leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes. Erratum:[Genomics 2002 Jun;79(6):890. Hepbiloikler Stefan [corrected to Hepbildikler Stefan]]"
4591a6232,6233
> "Q4JK59-1","RefSeq","NP_001333665.1","31043609","Study in mice lacking Tet2 and Tet3 in T-reg cells indicate that Tet2 and Tet3 are guardians of T-reg cell stability and immune homeostasis. Publication Status: Online-Only"
> "Q4JK59-1","RefSeq","NP_001333665.1","30796038","TET2 localizes to regions of open chromatin and cell-type-specific enhancers.  Loss of TET2 leads to attenuation of chromatin binding of the basic helix-loop-helix transcription factors."
4605a6248
> "A6H6S0-1","RefSeq","NP_082981.3","22790983","Allele-specific polyadenylation occurs at the imprinted Herc3/Nap1l5 locus."
4618a6262
> "Q9QYJ7-1","RefSeq","NP_038877.2","15252030","Expression of both MDSP and TMDP proteins was markedly increased at the 3rd week after birth and continued to increase gradually into adulthood, implying that the physiological functions of both DSPs are specific to the mature/late-developing organs"
4628,4629c6272,6273
< "Q8BG05-1","RefSeq","NP_666242.2","22546510","Characterization of hnRNP A3 in human and mouse cell lines"
< "Q8BG05-1","RefSeq","NP_666242.2","20885981","HnRNP A3 is a major liver nuclear protein binding to age related increase element of the factor IX gene. Publication Status: Online-Only"
---
> "Q9CZ30-1","RefSeq","NP_084367.1","27481995","Data demonstrate that OLA1 is required for normal progression of mammalian development. OLA1 plays an important role in promoting cell proliferation at least in part through suppression of p21 and organogenesis via factors yet to be discovered. Publication Status: Online-Only"
> "Q9CZ30-1","RefSeq","NP_084367.1","26984302","Cell transformation induced by the metal mixture NaAsO2, CdCl2, and Pb(C2H3O2)2.3H2O through ROS generation was rescued by OLA1 knockdown during the initiation stage of morphological transformation."
4635a6280
> "Q5HZI2-1","RefSeq","NP_941016.2","27349930","Our results suggest that C2cd4c is dispensable for pancreatic development."
4639a6285,6288
> "Q5NBU8-1","RefSeq","NP_001278082.1","29132171","Macrophages activated by metabolic endotoxemia infiltrated into islets and produced IFNbeta, which induced beta-cell apoptosis by increasing the expression of Xaf1."
> "Q5NBU8-1","RefSeq","NP_001278082.1","27097110","XAF1 may be a candidate tumor suppressor in neuroblastoma"
> "Q5NBU8-1","RefSeq","NP_001278082.1","18192275","Interferon gamma induces XAF1 and Noxa expression and potentiates apoptosis by STAT3 activation"
> "Q5NBU8-1","RefSeq","NP_001278082.1","18544999","XAF1 possesses a potential antiangiogenesis effect. Suppressed expression of Tie-1, Ang-1, Ang-2 and c-Myc may be mechanistically responsible for the observed antiangiogenesis effect."
4642,4645c6291,6294
< "O70628-1","RefSeq","NP_001157220.1","29505961","Brain PDE9 is localized to preferentially regulate nuclear- and membrane-proximal pools of cGMP, and its function likely changes across the life span."
< "O70628-1","RefSeq","NP_001157220.1","25799991","PDE9A can regulate cGMP signalling independent of the nitric oxide pathway, and its role in stress-induced heart disease suggests potential as a therapeutic target."
< "O70628-1","RefSeq","NP_001157220.1","22596207","Data suggest that increases in hippocampal and amygdalar cGMP levels via blockade of PDE9 have prominent roles in consolidation of extinction learning (here, prevention of learning disorder due to cocaine neurotoxicity)."
< "O70628-1","RefSeq","NP_001157220.1","9624146","This paper describes the human Pde9 gene but discusses the comparisons between the mouse and human Pde9 genes."
---
> "Q9D8B6-1","RefSeq","NP_080188.3","30366982","FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity"
> "P13864-1","RefSeq","NP_034196.5","21163962","Structure of DNMT1 composed of CXXC, tandem bromo-adjacent homology (BAH1/2), and methyltransferase domains bound to DNA-containing unmethylated CpG sites; studies identify an autoinhibitory mechanism of DNA methylation"
> "P13864-1","RefSeq","NP_034196.5","17371843","Data suggest that the biological functions of DNA methyltransferase 1 are exerted through the methylation of DNA."
> "P13864-1","RefSeq","NP_034196.5","15634679","This enzyme is a target of DNA methylation in embryogenesis."
4669a6319,6323
> "Q8R5A3-1","RefSeq","NP_062329.2","28348273","These data identify the requirement of RIAM for formation of immunological synapses and in resulting T cell functions in autoimmunity."
> "Q8R5A3-1","RefSeq","NP_062329.2","26337492","We show that leukocyte integrin activation critically depends on RIAM both in vitro and in vivo"
> "Q8R5A3-1","RefSeq","NP_062329.2","26324702","These in vivo results confirm a role for RIAM in the regulation of some, but not all, leukocyte integrins and suggest that RIAM-regulated integrin activation is required for trafficking of lymphocytes"
> "Q8R5A3-1","RefSeq","NP_062329.2","25520155","Conformational activation of talin by PREL-1 triggers integrin-mediated cell adhesion. Publication Status: Online-Only"
> "Q8R5A3-1","RefSeq","NP_062329.2","20404115","Data demonstrate a novel mechanism by which alphavbeta3 integrin acts to locally suppress beta1 integrin activation and regulate VASP and RIAM to control cell adhesion and migration."
4678d6331
< "Q61137-1","RefSeq","NP_001192133.1","11861479","Astrotactin is required for appropriate and timely migration of cerebellar granule cells."
4688a6342,6344
> "P0DP28-1","RefSeq","NP_033920.1","30230921","Calmodulin regulates MGRN1-GP78 interaction mediated ubiquitin proteasomal degradation system."
> "P0DP28-1","RefSeq","NP_033920.1","29518331","Demonstrate that RGS14 is a novel CaM effector and CaMKII phosphorylation substrate thereby providing new insight into mechanisms by which RGS14 controls plasticity in CA2 neurons."
> "P0DP28-1","RefSeq","NP_033920.1","26711345","Both FMRP deficiency in Fmr1(I304N) mice and Fmr1 knockdown impeded the axonal delivery of miR-181d, Map1b, and Calm1 and reduced the protein levels of MAP1B and calmodulin in axons."
4693a6350,6352
> "Q9WVE8-1","RefSeq","NP_035992.1","29107716","Pacsin 2 is necessary for cardiac development and function in mouse embryos."
> "Q5F2E8-1","RefSeq","NP_659074.2","17417629","Functional analysis of the human Tao1 ortholog."
> "Q5F2E8-1","RefSeq","NP_659074.2","9786855","Isolation and functional characterization of the rat Taok1 ortholog, and comparison to human TAOK1."
4696a6356,6359
> "Q8C2S5-1","RefSeq","NP_848844.1","29470856","Increased intracellular growth due to compromised expressions of Fpn and FBXL5 by specific siRNAs reveals that Leishmania donovani uses a novel strategy of manipulating IRP2-FBXL5 axis to inhibit host Fpn expression."
> "Q8C2S5-1","RefSeq","NP_848844.1","28714470","Conditional deletion of Fbxl5 in mouse HSCs results in cellular iron overload and a reduced cell number. Bone marrow transplantation reveals that FBXL5-deficient HSCs are unable to reconstitute the hematopoietic system of irradiated recipients as a result of stem cell exhaustion. Transcriptomic analysis shows abnormal activation of oxidative stress responses and the cell cycle in FBXL5-deficient mouse HSCs. Publication Status: Online-Only"
> "Q8C2S5-1","RefSeq","NP_848844.1","28069738","FBXL5 contributes to regulation of neural stem progenitor cell proliferation during mammalian brain development. Publication Status: Online-Only"
> "Q8C2S5-1","RefSeq","NP_848844.1","24508277","We describe the iron and oxygen sensing mechanisms of the FBXL5 Hr-like domain and its role in mediating ROS biology. Review article"
4700a6364,6365
> "P97489-1","RefSeq","NP_032119.2","26617239","GATA5 is expressed in microvascular endothelial cells and its inactivation in mice leads to vascular endothelial dysfunction and hypertension. Publication Status: Online-Only"
> "P51163-1","RefSeq","NP_033505.1","21365124","Data show that in adult UROS C73R mice, spleen and liver weights were 8.2- and 1.5-fold increased, respectively."
4707,4710c6372,6378
< "Q9QYP6-1","RefSeq","NP_001273437.1","23610142","AZI2 expression is critical for the generation of cDCs by GM-CSF and can potentially be used to increase the efficiency of immunization by cDCs."
< "Q9QYI5-3","RefSeq","NP_001153355.1","21832061","Hsc70, Hdj1 and Hdj2 interact with soluble and fibrillar alpha-synuclein"
< "Q9QYI5-3","RefSeq","NP_001153355.1","20395441","Data show that DNAJB2 is expressed in skeletal muscle at the neuromuscular junction of normal fibers, in the cytoplasm and membrane of regenerating fibers, and in protein aggregates and vacuoles in protein aggregate myopathies."
< "Q9QYI5-3","RefSeq","NP_001153355.1","16604191","Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase"
---
> "Q8BH97-1","RefSeq","NP_080831.2","26252542","Results indicate an essential role of Rcn3 in perinatal lung maturation and neonatal respiratory adaptation as well as shed additional light on the mechanism of neonatal respiratory distress syndrome development."
> "O35682-1","RefSeq","NP_058665.2","16172915","Functional analysis of the promotor region of the MYADM gene."
> "Q9CUN6-1","RefSeq","NP_083714.3","30449452","Smurf1 expression in osteoblast differentiation is regulated by CRTC2."
> "Q9CUN6-1","RefSeq","NP_083714.3","30143635","Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis Publication Status: Online-Only"
> "Q9CUN6-1","RefSeq","NP_083714.3","29934521","SMURF1 is a critical regulator of outflow tract septation and cell-type specification during heart development Publication Status: Online-Only"
> "Q9CUN6-1","RefSeq","NP_083714.3","12738770","Smurf1 appears to be an important regulatory factor in osteoblast differentiation and a potential molecular target for identification of bone anabolic agents"
> "Q9CUN6-1","RefSeq","NP_083714.3","10458166","Initial identification of Smurf1 as an ubiquitin ligase that inhibits BMP signaling by targeting Smad1/5 for proteasomal destruction in cultured cells and Xenopus embryos."
4719a6388,6396
> "Q9WVS8-1","RefSeq","NP_035971.1","29723698","The data revealed that puerarin inhibited the monocyte adhesion in vitro and in vivo and thus reduced atherosclerotic lesions in apoE-/- mice; the protective effects were mediated by activation of ERK5/KLF2 signaling pathway."
> "Q9WVS8-1","RefSeq","NP_035971.1","29986870","These findings highlight the importance of the Mek5-Erk5-Smurf-Smad-Sox9 axis in mammalian skeletogenesis. Publication Status: Online-Only"
> "Q9WVS8-1","RefSeq","NP_035971.1","29159830","Extracellular-signal-regulated kinase 5 plays an essential role in the gestational augmentation of beta-cell proliferation."
> "Q9WVS8-1","RefSeq","NP_035971.1","29038439","Novel role for Erk5 during bone maturation and homeostasis Publication Status: Online-Only"
> "Q9WVS8-1","RefSeq","NP_035971.1","28887535","Erk5 role in the cardiac mitochondria and the Pgc-1alpha regulation Publication Status: Online-Only"
> "Q9WVS8-1","RefSeq","NP_035971.1","12093914","Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects."
> "O54990-1","RefSeq","NP_001157055.1","30328220","Prominin-1 regulates microvilli architecture and dynamics."
> "O54990-1","RefSeq","NP_001157055.1","29772232","Hypomyelination in CD133(-/-) mice was associated with fewer oligodendrocyte progenitor cells and mature oligodendrocytes. Behavioral analyses revealed that significantly impaired object recognition memory and altered Y-maze performance by CD133(-/-) mice compared with wild-type mice, suggesting perturbed cognitive performance."
> "O54990-1","RefSeq","NP_001157055.1","29431914","CD133 itself appears to play a functional role in renal tubular repair through maintenance of proliferative response and control of senescence."
4730a6408,6417
> "Q9R210-1","RefSeq","NP_035679.3","30528240","The effect of SIK2 on autophagic flux occurs before the regulation of TFEB protein levels, suggesting different mechanisms whereby SIK2 stimulates autophagy."
> "Q9R210-1","RefSeq","NP_035679.3","30503207","TFEB functions cell-autonomously through PUMA induction and Bax-Bak activation to promote programmed cell death of a subset of premyelinating oligodendrocytes, allowing selective elimination of oligodendrocytes in normally unmyelinated brain regions."
> "Q9R210-1","RefSeq","NP_035679.3","30520728","Expression of multiple genes implicated in cell cycle control is altered in TFEB/TFE3 DKOs, revealing a previously unrecognized role of TFEB and TFE3 in the regulation of cell cycle checkpoints in response to stress. Publication Status: Online-Only"
> "Q9R210-1","RefSeq","NP_035679.3","30360758","Data show that during testicular development, transcriptional factor EB (TFEB) expression was rapidly increased in the testes at the period of 7 days post-partum (dpp) to 14 dpp. Publication Status: Online-Only"
> "P22727-1","RefSeq","NP_033552.2","28177772","A negative feedback loop involving WNT6 and DKK1 attenuates canonical WNT6-beta-catenin signaling, thereby allowing teratocarcinoma cells to differentiate."
> "Q9DCA7-1","RefSeq","NP_081045.2","28734834","Endocytic and cargo sorting functions of Caly in neurons"
> "Q9DCA7-1","RefSeq","NP_081045.2","22650988","The data of this study suggested that calcyon directly interacts with mu3A and mu3B, and regulates the subcellular distribution of AP-3 and the targeting of AP-3 cargoes."
> "Q9DCA7-1","RefSeq","NP_081045.2","21403673","The resultd of this study showed that with calcyon-overexpressing Cal(OE) transgenic mice that lifelong calcyon upregulation impairs executive functions including response inhibition and working memory."
> "Q9DCA7-1","RefSeq","NP_081045.2","19120439","Taken together, the present studies involving biochemical, immunological and electrophysiological analyses raise the possibility that calcyon plays a specialized role in regulating activity-dependent removal of synaptic AMPARs."
> "Q9DCA7-1","RefSeq","NP_081045.2","18295356","Transgenic mice display a range of abnormal behaviors including spontaneous hyperactivity, reduced anxiety, and/or impaired restraint (harm avoidance) that would indicate that calcyon up-regulation leads to deficits in control over behavioral output."
4750a6438
> "A2AM05-1","RefSeq","NP_796359.1","26915804","Taken together, we propose that centlein is involved in MT stability and neuritogenesis in vivo."
4761a6450,6454
> "Q8VCQ6-1","RefSeq","NP_659041.3","30243987","Knockdown of SMS1 promotes lysosomal degradation of BACE1 and attenuates Alzheimer's disease-like pathology in transgenic mice."
> "Q8VCQ6-1","RefSeq","NP_659041.3","30305392","2-Hydroxy-oleic acid inhibited rather than activated recombinant SMS1 (rSMS1) and rSMS2 in a dose-dependent fashion. Erratum:[J Biol Chem. 2019 May 31;294(22):8716. PMID: 31152097]"
> "Q8VCQ6-1","RefSeq","NP_659041.3","27892528","SMS1 contributed to sphingomyelin generation inducing Japanese encephalitis virus attachment and infection. Publication Status: Online-Only"
> "Q8CIG8-1","RefSeq","NP_038796.2","30604754","Prmt5 is necessary for antibody responses and has essential but distinct functions in all proliferative B cell stages in mice. Prmt5 is necessary for B cell development by preventing p53-dependent and p53-independent blocks in Pro-B and Pre-B cells, respectively. Publication Status: Online-Only"
> "Q8CIG8-1","RefSeq","NP_038796.2","30082494","PRMT5 contributes to germinal center formation and affinity maturation at least in part through its direct interaction with and methylation of BCL6 at arginine 305 (R305), a modification necessary for the full transcriptional repressive effects of BCL6."
4762a6456,6457
> "A7M7C7-1","RefSeq","NP_001103213.1","27449513","The first SNP rs29972765 is located in a gene desert on chromosome 18, about 72 kb upstream of Skor2 . The second SNP rs30415957 resides in the intron of Plce1.The remaining two SNPs (rs30768258 and rs31216810) are close to each other on chromosome 19, in the vicinity of Sorbs1.  Knockdown of Sorbs1 by siRNA attenuates the induction of differentiation marker gene Prl8a2 Publication Status: Online-Only"
> "A7M7C7-1","RefSeq","NP_001103213.1","18522874","Results strongly suggest that Corl2 is a specific marker for Purkinje cells in the cerebellum from their emergence until the adult stage."
4789,4792d6483
< "Q3US41-1","RefSeq","NP_001277312.1","30049844","Bleomycin (BLM) inhibited the expression of epithelial splicing regulatory protein 1 (ESRP1), resulting in enhanced alternative splicing of FGFR2 to the mesenchymal isoform IIIc. BLM-induced lung fibrosis was also associated with the activation of TGF-b/Smad signaling. Publication Status: Online-Only"
< "Q3US41-1","RefSeq","NP_001277312.1","29324788","Study documented the expression of Esrp1 during gonadal development and in differentiating cells of the adult gonads: in mouse fetal gonads, Esrp1 mRNA was specifically detected in germ cells of either sex and absent from somatic gonadal cells. Esrp1 mRNA was present in a gonocyte-enriched cell fraction and in all germ cells examined in postnatal testis. Publication Status: Online-Only"
< "Q3US41-1","RefSeq","NP_001277312.1","29107558","Implicate mutations in Epithelial Splicing-Regulatory Protein 1 as a cause of SNHL and demonstrate the complex interplay between alternative splicing"
< "Q3US41-1","RefSeq","NP_001277312.1","19285943","Epithelial splicing regulatory proteins 1/2 (ESRP1/2) are epithelial cell-type-specific regulators of FGFR2 splicing."
4814a6506,6507
> "P12813-1","RefSeq","NP_034574.1","30930165","TR3/Nur77 regulated the expression of DLL4 and Jagged1 in culture endothelial cells. DLL4 and Jagged1 play important roles in the angiogenic responses induced by TR3/Nur77."
> "P12813-1","RefSeq","NP_034574.1","30277475","These data identify NR4A1 as a previously unrecognized constitutive regulator of AP quiescence and suggest that augmentation of adipose tissue plasticity may attenuate negative metabolic sequelae of obesity."
4818a6512,6520
> "Q9JJL9-1","RefSeq","NP_065236.1","28600286","Findings suggest that a leukotriene B4 receptor-2-linked cascade plays a pivotal role in LPS/TLR4 signaling for IL-13 synthesis in mast cells, thereby potentially exacerbating allergic response."
> "Q9JJL9-1","RefSeq","NP_065236.1","28546450","FABP4 regulates the expression of BLT1R and its downstream signaling via control of oxidative stress in macrophages"
> "Q9JJL9-1","RefSeq","NP_065236.1","28242764","The data show that the two leukotriene B4 receptors have opposing roles in the sensitization of peripheral sensory neurons forming a self-restricting system."
> "Q9JJL9-1","RefSeq","NP_065236.1","28053185","This study demonstrates that LTB4 promotes macrophage phagocytosis of bacteria via BLT1, and that BLT2 can fulfill this role in the absence of BL"
> "Q9JJL9-1","RefSeq","NP_065236.1","15866883","BLT2 is a leukotriene B4 receptor with a role in ERK activation and cell migration of primary mouse keratinocytes"
> "Q9JJL9-1","RefSeq","NP_065236.1","12895595","360 amino acid sequence determined and aligned with human sequence Review article"
> "Q58A65-1","RefSeq","NP_081845.2","28521278","JLP-deficiency impaired T-cell proliferation."
> "Q58A65-1","RefSeq","NP_081845.2","26320416","JSAP1 and JLP play critical roles in kinesin-1-dependent axonal transport"
> "Q58A65-1","RefSeq","NP_081845.2","12391307","Describe a protein, JLP, which acts as a scaffolding protein to bring mitogen-activated protein kinases and their target transcription factors together for the execution of specific signaling pathways"
4826a6529,6531
> "Q9Z261-1","RefSeq","NP_058583.1","30774273","The knockout of Claudin-7 in vivo causes extensive inflammation, atypical hyperplasia, and adenoma in intestinal tissue as well as animal death in mice. Claudin-7 may act as a tumor suppressor gene in the development of colorectal cancer."
> "Q9Z261-1","RefSeq","NP_058583.1","29488037","Intestinal Cldn7 deletion initiated inflammation and hyperplasia in mice."
> "Q9Z261-1","RefSeq","NP_058583.1","14722018","Claudin-7 was found in the same nephron segments as claudin-8, but it was expressed primarily at the basolateral membrane"
4828a6534,6540
> "Q6AXC6-1","RefSeq","NP_001335221.1","17611414","ChlR1 is essential for embryonic development and the prevention of aneuploidy in mammals."
> "Q9ESL4-1","RefSeq","NP_835185.2","27598200","Zak-/- mice demonstrate a distinct ribotoxic stress-associated phenotype in response to ricin. Publication Status: Online-Only"
> "Q9ESL4-1","RefSeq","NP_835185.2","26755636","ZAK is a key player in mammalian limb patterning in humans and mice."
> "Q9ESL4-1","RefSeq","NP_835185.2","24789282","Exome sequencing analysis between SM/J and A/J mice identified 4 genes (Itga6, Zak, Gpr155, and Mtx2) with nonsynonymous coding SNPs. These four genes might be candidate genes for type 2 diabetes caused by gene-gene interactions. Publication Status: Online-Only"
> "Q9ESL4-1","RefSeq","NP_835185.2","15737997","Mixed lineage kinase 7 (MLK7), a splice variant of the human ZAK gene (ortholog of mouse B230120H23Rik), encodes an isoform which is the MAPKKK required for modulation of the stress-activated MAPKs downstream of anisomycin and UV stimulation."
> "Q9ESL4-1","RefSeq","NP_835185.2","15684425","Results show that mixed lineage kinase-like mitogen-activated protein triple kinase (MLTK_-alpha plays a key role in the UVB- and EGF-induced phosphorylation of histone H3 at Ser28."
> "Q9ESL4-1","RefSeq","NP_835185.2","12761180","PKNalpha functions as not only an upstream activator of MLTKalpha but also a putative scaffold protein for the p38gamma MAPK signaling pathway"
4845c6557
< "P63056-1","RefSeq","NP_694797.1","16115881","Pax6 regulation of Optimedin in the eye and brain may directly affect multiple developmental processes, including cell migration and axon growth"
---
> "A8Y5H7-1","RefSeq","NP_083053.2","15531584","The Sec14 domain regulates Dbs transformation through at least two distinct mechanisms, neither of which appears to directly influence the in vivo exchange activity of the protein"
4851a6564,6572
> "O54928-1","RefSeq","NP_062628.2","28196914","Data show that the Japanese encephalitis virus (JEV)-induced expression of miR-301a led to inhibition of the production of the transcription factor IFN regulatory factor 1 (IRF1) and the signaling protein suppressor of cytokine signaling 5 (SOCS5). Publication Status: Online-Only"
> "O54928-1","RefSeq","NP_062628.2","27183640","This study shows that DRD3 signaling evokes Socs5 expression, a negative regulator of Th2 development, which indirectly favors acquisition of Th1 phenotype"
> "O54928-1","RefSeq","NP_062628.2","26173083","Have identified a phosphorylation site (Ser211) within the JIR of mSOCS5 and have investigated the role of phosphorylation in modulating JAK binding using site-directed mutagenesis."
> "O54928-1","RefSeq","NP_062628.2","12242343","SOCS5 regulates Th1/Th2 cell balance and suppresses IL-4"
> "Q9JKD3-1","RefSeq","NP_064666.1","19240033","Exposure to ER stress increases SCAMP5 in the striatum, which positively regulates mtHTT aggregation via the endocytosis pathway"
> "Q9DBY0-1","RefSeq","NP_083043.2","27341756","Combined loss of all three Foxp1/2/4 family members in the developing anterior foregut endoderm leads to a loss of lung endoderm lineage commitment and subsequent development. Foxp1/2/4 deficient lungs express high levels of transcriptional regulators not normally expressed in developing lung. Ectopic expression of these transcriptional regulators is accompanied by decreased expression of lung restricted transcription."
> "Q9DBY0-1","RefSeq","NP_083043.2","14701752","Complex regulatory mechanism underlying Foxp1, Foxp2, and Foxp4 activity, demonstrating that Foxp1, Foxp2, and Foxp4 are the first Fox proteins reported whose activity is regulated by homo- and heterodimerization"
> "Q9DBY0-1","RefSeq","NP_083043.2","12818433","In adult tissues FoxP4 is expressed in heart, brain, lung, liver, kidney, and testis.In situ hybridization revealed expression of FoxP4 in the developing lung and gut"
> "Q9DBY0-1","RefSeq","NP_083043.2","12617805","Foxp4 is expressed exclusively in the epithelial cells of the developing intestine, where, in late development, it is expressed in a gradient along the longitudinal axis of the villi"
4853c6574,6575
< "O55047-1","RefSeq","NP_001281260.1","28708136","TLK1 and TLK2 have largely redundant roles in genome maintenance."
---
> "Q68EF6-1","RefSeq","NP_001156647.1","27785460","BEGAIN was highly localized at the synapse of inner lamina II in the spinal dorsal horn and that its expression was up-regulated after peripheral nerve injury in wild-type, but not in GluN2B Y1472F-KI, mice. Mechanical allodynia was significantly attenuated in BEGAIN-deficient mice, but no change was observed in terms of physiological threshold for mechanical stimuli. Publication Status: Online-Only"
> "Q68EF6-1","RefSeq","NP_001156647.1","19641963","A Begain transcript variant is preferentially expressed from the paternal allele."
4878a6601,6602
> "Q80U04-1","RefSeq","NP_659108.1","27195677","Praja2 regulates KSR1 stability and mitogenic signaling. Publication Status: Online-Only"
> "Q80U04-1","RefSeq","NP_659108.1","24561619","The SIK2-p35-PJA2 complex is essential for glucose homeostasis and provides a link between p35-CDK5 and the AMPK family in excitable cells. Erratum:[Nat Cell Biol. 2014 Apr;16(4):382]"
4881a6606
> "Q6ZPE2-1","RefSeq","NP_001164032.1","11994405","Expressed at high levels in seminiferous tubules of the testis; mice that are nullizygous for Sbf1 exhibit male infertility characterized by azoospermia."
4888d6612
< "Q9JIL6-1","RefSeq","NP_001192325.1","15086536","GPRC5D is involed in the regulation of keratin synthesis in hard epithelial tissue."
4898a6623
> "Q8C167-1","RefSeq","NP_666096.3","23321636","The data demonstrate PREPL as an AP-1 effector that takes part in the regulation of AP-1 membrane binding. PREPL is highly expressed in brain and at lower levels in muscle and kidney."
4902c6627,6629
< "Q3U4H6-1","RefSeq","NP_001001333.2","21807949","Lipid-droplet-targeted isoform is a key regulator of the proteasome"
---
> "P97863-1","RefSeq","NP_032713.3","29965871","Results imply that the long noncoding RNA lnc158 positively modulates the transcription level of nuclear factor-IB mRNA, leading to the enhanced induction of oligodendrocytes."
> "Q5DTX6-1","RefSeq","NP_001075432.1","28705794","JCAD has a redundant functional role in physiological angiogenesis but serves a pivotal role in pathological angiogenic process after birth."
> "Q5DTX6-1","RefSeq","NP_001075432.1","21884682","These results indicate that JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. This study also suggests the implication of endothelial cell-cell adhesion in coronary artery disease."
4911a6639,6641
> "P35329-1","RefSeq","NP_033975.3","30323814","Several studies in autoimmune-prone mice have identified Cd22 as a candidate gene associated with susceptibility to lupus-like disease. Review article Publication Status: Online-Only"
> "P35329-1","RefSeq","NP_033975.3","29617956","We identified CD22 as a marker of dysregulated microglia in Npc1 mutant mice and subsequently demonstrated that elevated cerebrospinal fluid levels of CD22 in NPC1 patients responds to HPbetaCD administration. Collectively, these data provide the first in-depth analysis of microglia function in NPC1 and suggest possible new therapeutic approaches."
> "P35329-1","RefSeq","NP_033975.3","29725338","Synthetic sialosides that bind to CD22 with high-affinity modulate B cell activation through endogenous ligand-dependent and independent pathways, and carry an adjuvant activity without inducing inflammation. Publication Status: Online-Only"
4926a6657,6658
> "Q6PFD9-1","RefSeq","NP_075355.1","28392395","We demonstrated that Nup98-TopIIbeta and Nup98-SETBP1 negatively regulate the XPO1-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98-fusion proteins induce tumorigenesis."
> "Q6PFD9-1","RefSeq","NP_075355.1","26202421","The age-associated accumulation of somatic mutations that occurs in the Nup98-HOXD13 (NHD13) mouse model of leukemia progression was significantly elevated by co-expression of a PKR transgene."
4934,4939d6665
< "Q8VIK5-1","RefSeq","NP_001027585.1","29577896","Expression of the myogenic markers Desmin, MYOG, and MYH2 revealed that PEAR1 positively regulated C2C12 cell differentiation"
< "Q8VIK5-1","RefSeq","NP_001027585.1","26156496","Platelet endothelial aggregation receptor-1: a novel modifier of neoangiogenesis."
< "Q8VIK5-1","RefSeq","NP_001027585.1","24743597","Jedi-1 signals through recruitment of GULP, which promotes phagocytosis through a noncanonical phosphoclathrin-dependent mechanism."
< "Q8VIK5-1","RefSeq","NP_001027585.1","22993420","These results indicated that both Jedi-1 and MEGF10 can mediate phagocytosis independently through the recruitment of Syk."
< "Q8VIK5-1","RefSeq","NP_001027585.1","19915564","A cellular and molecular mechanism by which neuronal corpses are culled during dorsal root ganglia development involves Jedi protein"
< "Q8VIK5-1","RefSeq","NP_001027585.1","17226770","Jedi is involved in the fine regulation of the early stages of hematopoietic differentiation, presumably through the Notch signaling pathway."
4943,4944c6669,6671
< "Q4JK59-1","RefSeq","NP_001035490.2","31043609","Study in mice lacking Tet2 and Tet3 in T-reg cells indicate that Tet2 and Tet3 are guardians of T-reg cell stability and immune homeostasis. Publication Status: Online-Only"
< "Q4JK59-1","RefSeq","NP_001035490.2","30796038","TET2 localizes to regions of open chromatin and cell-type-specific enhancers.  Loss of TET2 leads to attenuation of chromatin binding of the basic helix-loop-helix transcription factors."
---
> "O70480-1","RefSeq","NP_001334054.1","22889194","Cholesterol modulates Vamp4 distribution in insulin granule membranes."
> "O70480-1","RefSeq","NP_001334054.1","12682051","The cytoplasmic domain of this protein is responsible for its correct subcellular targeting, the N-terminal extension contains a dominant autonomous targeting signal for the trans-golgi network"
> "Q6RFH4-1","RefSeq","NP_032125.3","15482850","Assays identified a non-consensus binding site for Sp factors near sites of transcriptional initiation. The site binds Spl and Sp3 in nuclear extracts."
4949,4950c6676
< "Q9CSU0-1","RefSeq","NP_001278063.1","28893536","Mechanistically, CREPT regulated beta-catenin/TCF4/cyclin D1 pathway in BC. In conclusion, the data suggested that miR-138/CREPT involved BC progression, providing potential therapeutic targets for BC."
< "Q9CSU0-1","RefSeq","NP_001278063.1","24982424","Study suggests that CREPT acts as an activator to promote transcriptional activity of the beta-catenin.TCF4 complex in response to Wnt signaling."
---
> "P52483-1","RefSeq","NP_033480.1","16024774","UBC4-testis isoform plays a role in early maturation of the testis"
4952a6679,6680
> "P30548-1","RefSeq","NP_033339.2","30472211","This study demonstrates that the downstream consequences of Mild traumatic brain injury on lung NK1R levels and connective protein expression enhance neutrophil recruitment to a stimulus that may contribute to increased survival."
> "P30548-1","RefSeq","NP_033339.2","29459872","Our results suggest that the NK1 receptor contributes to the early phase of LPS-induced fever by enhancing COX-2 protein expression in the periphery. Publication Status: Online-Only"
4954a6683,6686
> "Q99JR6-1","RefSeq","NP_653116.1","29901258","The results suggest that Nmnat3 overexpression improves metabolic health and that Nmnat3 is an attractive therapeutic target for metabolic disorders that are caused by aging."
> "Q99JR6-1","RefSeq","NP_653116.1","27423420","NMNAT3 regulates the activity of SIRT3 via synthesis of mitochondria NAD."
> "Q99JR6-1","RefSeq","NP_653116.1","26756334","Results indicated that Nmnat3 is dispensable in the maintenance of mitochondrial NAD levels, and that other NAD regulatory pathways may exist in mitochondria. Publication Status: Online-Only"
> "Q99JR6-1","RefSeq","NP_653116.1","19439605","Results suggest that axonal protection by NMNAT expression in neurons is provided by modifying mitochondrial functionNMNAT activity does lead to axonal protection phenotype in vivo"
4962a6695
> "Q8BZL8-1","RefSeq","NP_997105.1","29609111","These results suggest that Lmo3 promotes anxiety-like behavior specifically in the BLA, possibly by altering Crhr1 expression."
4975a6709,6711
> "Q8K377-1","RefSeq","NP_083156.2","29784826","Genetic deletion of LRRTM1,2 in vivo in CA1 neurons using Cre recombinase-expressing lentiviruses dramatically impaired long-term potentiation (LTP), an impairment that was rescued by simultaneous expression of LRRTM2, but not LRRTM4."
> "Q8K377-1","RefSeq","NP_083156.2","29424692","Using an unbiased transcriptomics approach and targeted mutant mice, the authors discovered a critical role for the synaptic adhesion molecule Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1) in the emergence of retinothalamic convergence. Publication Status: Online-Only"
> "Q8K377-1","RefSeq","NP_083156.2","25527504","Data indicate that neural Cell Adhesion Molecules Lrrtm1 and Lrrtm2 mRNA expression is controlled by synaptic activity and nuclear calcium signaling."
4982a6719,6723
> "P30999-1","RefSeq","NP_031641.2","29875160","This study concluded that by undergoing cleavage, delta-catenin differentially regulates the densities of subpopulations of dendritic spines and contributes to proper neural circuit wiring in the developing brain."
> "P30999-1","RefSeq","NP_031641.2","29923340","In the present study, we generated a conditional knockout mouse model and examined epidermal proliferation, differentiation and permeability. The results showed that conditional knockout of p120 in the epidermis caused not only increased epidermal proliferation but also decreased epidermal differentiation and increased permeability"
> "P30999-1","RefSeq","NP_031641.2","29130932","P120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia."
> "Q1EG27-1","RefSeq","NP_796350.2","26754646","Results uncover the critical role that class III myosins play redundantly in hair-bundle morphogenesis"
> "Q1EG27-1","RefSeq","NP_796350.2","22264607","When myosin IIIB (MYO3B) is coexpressed with espin-1 (ESPN1), MYO3B targets and carries ESPN1 to COS7 cell filopodia tips. This tip localization is lost when the ESPN1 C terminus actin-binding site is removed."
4997a6739,6740
> "Q60809-1","RefSeq","NP_035265.1","28723570","This study identifies CNOT7 as an important regulator of RNA transport and translation in dendrites, as well as higher cognitive function."
> "Q60809-1","RefSeq","NP_035265.1","27605379","Study reports that a complex of BTG4 and CAF1 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs"
5010a6754
> "Q9D2Y5-1","RefSeq","NP_082116.1","25882846","SAXS solution structures of SNX20 and SNX21 show that the proteins adopt a compact globular architecture; membrane interaction analyses indicate the presence of phosphoinositide -binding sites that may regulate their intracellular localization."
5012,5014d6755
< "O54965-1","RefSeq","NP_001106884.1","26197965","Host RNF13 affects the concentration of GM-CSF in tumor-bearing lungs"
< "O54965-1","RefSeq","NP_001106884.1","24563216","These results indicate that RNF13 deficiency promotes skeletal muscle regeneration via the effects on satellite cell niche mediated by IL-4 and IL-6."
< "O54965-1","RefSeq","NP_001106884.1","22890573","RNF13 is involved in the regulation of the SNARE complex, which thereby controls synaptic function."
5028a6770,6777
> "Q9WUD8-1","RefSeq","NP_035940.3","27767058","The neuron-specific form of FAIM protein (FAIM-L) is a death receptor antagonist that stabilizes XIAP protein levels, thus preventing death receptor-induced neuronal apoptosis. Here we show that FAIM-L modulates synaptic transmission, prevents chemical-LTD induction in hippocampal neurons, and thwarts axon degeneration after nerve growth factor (NGF) withdrawal. Publication Status: Online-Only"
> "Q9WUD8-1","RefSeq","NP_035940.3","26866272","Data indicate that FAIM is a novel regulator of insulin signalling and plays an essential role in energy homoeostasis. Publication Status: Online-Only"
> "Q9WUD8-1","RefSeq","NP_035940.3","20178987","Defined a TCR-induced FAIM/Akt/Nur77 signaling axis that is critical for modulating the apoptosis of developing thymocytes"
> "Q60862-1","RefSeq","NP_032791.1","22674395","Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote. Publication Status: Online-Only"
> "Q60862-1","RefSeq","NP_032791.1","17157410","Depletion of Orc2 and Mcm3 by siRNA leads to an inhibition of cell proliferation, an altered cell cycle distribution as well as to multinucleated cells with insufficiently organised microtubules."
> "Q61845-1","RefSeq","NP_032605.1","29393537","Mouse meiosis expressed gene 1 is not phosphorylated in vivo."
> "Q61845-1","RefSeq","NP_032605.1","25715396","Studies demonstrate that MEIG1/PACRG forms a complex in the manchette and that this complex is necessary to transport cargos, such as SPAG16L, to build the sperm flagella."
> "Q61845-1","RefSeq","NP_032605.1","25248657","MORN3 is another regulator for spermatogenesis, probably together with MEIG1."
5036a6786,6790
> "Q6R0H7-1","RefSeq","NP_963911.1","30266511","Gsalpha signaling in osteocytes leads to osteopenia driven, at least in part, by increased secretion of sclerostin."
> "Q6R0H7-1","RefSeq","NP_963911.1","30142336","In mice that express activated KRAS in the pancreas, we found expression of GNAS(R201C) to cause development of more differentiated tumors, with gene expression pattern associated with the ductal phenotype."
> "Q6R0H7-1","RefSeq","NP_963911.1","15798190","Maternally expressed Nesp55 plays a role in controlling exploratory behavior."
> "Q6R0H7-1","RefSeq","NP_963911.1","15148396","Data report that the XL exon of Gsalpha is longer than presumed and contributes an additional 364 codons to XLalphas."
> "Q6R0H7-1","RefSeq","NP_963911.1","10097123","Gnas gene exhibits a complex imprinted pattern, giving rise to transcripts that are maternally, paternally, or biallelically expressed."
5042a6797,6799
> "B2RPV6-1","RefSeq","NP_081889.1","28266709","C57BL/6J-OlaHsd mice, a substrain of C57BL/6J carrying mutated alpha-synuclein and multimerin-1 genes, have an altered bone phenotype."
> "B2RPV6-1","RefSeq","NP_081889.1","20138333","Our data suggest that multimerin 1 supports platelet adhesive functions and thrombus formation, which will be important to verify by generating and testing selective multimerin 1 deficient mice."
> "Q99MR1-1","RefSeq","NP_113596.2","12771153","Identification of proteins linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling"
5048a6806,6807
> "P50295-1","RefSeq","NP_035004.1","28888949","This study illustrated that deficiency of NAT1/2 decreases isoniazid (INH) acetylation, but increases the interactions of INH with endobiotics in the liver."
> "P50295-1","RefSeq","NP_035004.1","24742986","It was concluded that an acute colonic inflammation impairs the expression and function of NAT2 enzyme, thereby diminishing the capacity for 5-aminosalisylic acid metabolism by colonic mucosa."
5062a6822
> "Q924Z6-1","RefSeq","NP_083092.2","22323606","Measurements of nuclear export rates and depletion studies clarified that nuclear export of actin is mediated by exportin 6."
5067a6828,6829
> "Q9D842-1","RefSeq","NP_077213.2","27875275","The downregulation of histone chaperone Aprataxin PNK-like factor (APLF) promotes reprogramming by augmenting the expression of E-cadherin. Erratum:[J Cell Sci. 2018 Apr 19;131(8):. PMID: 29674330]"
> "Q9D842-1","RefSeq","NP_077213.2","21211721","APLF has a role in chromosomal DNA double-strand break repair."
5080a6843,6845
> "Q3UNH4-1","RefSeq","NP_036144.2","18597079","Responses to social novelty and nonspatial change remained unaffected, indicating that the Grin1(D481N) mutation induces selective deficits in sociability and spatial discrimination, while leaving intact the ability to react to novelty."
> "Q3UNH4-1","RefSeq","NP_036144.2","18729205","Data show that GRIN1 expression was limited to the nervous system at all developmental stages tested. GRIN1 colocalized with Galphao at neuronal dendrites and axons, but it was not detected in glial cells."
> "Q3UNH4-1","RefSeq","NP_036144.2","15585744","Binding of activated Galphao to GRIN1 induces activation of Cdc42, which leads to morphological changes in neuronal cells."
5091,5095c6856,6857
< "Q91W10-1","RefSeq","NP_001128621.1","29927321","Hepatic ZIP8 knockdown leads to selenium deficit, liver pathology, oxidative stress and tumor formation. Erratum:[Am J Physiol Gastrointest Liver Physiol. 2018 Nov 1;315(5):G908. PMID: 30444645]"
< "Q91W10-1","RefSeq","NP_001128621.1","29337306","Slc39a8 is expressed in the developing heart and regulates Zn levels. Slc39a8 deletion results in hypertrabeculation and noncompaction."
< "Q91W10-1","RefSeq","NP_001128621.1","28481222","ZIP8 reclaims Mn from bile and regulates whole-body Mn homeostasis."
< "Q91W10-1","RefSeq","NP_001128621.1","28057442","Intravitreal holo-transferrin injection decreased Zip 14 protein levels. These data indicate that Zip8 and Zip14 may take up increasing amounts of non-transferrin bound iron in these two mouse models of retinal iron accumulation."
< "Q91W10-1","RefSeq","NP_001128621.1","17108009","Cd treatment caused acute renal failure and signs of proximal tubular damage in the BTZIP8-3 but not nontransgenic littermates. BTZIP8-3 mice should be a useful model for studying Cd-induced disease in kidney."
---
> "P59054-1","RefSeq","NP_695019.1","28830684","Axud1 mediated stress-induced cardiomyocytes apoptosis through activating Wnt/beta-catenin signaling pathway."
> "P59054-1","RefSeq","NP_695019.1","23533084","Significant increases in Col1a1, serine/threonine-protein kinase 1, Ctnnb1, CSRNP1, Ddit4, Cyp2e1, and Krit1 expressions and great decreases inreceptor D2, Neu1, and Dhcr7 expressions following long-term exposure to TiO2 NPs"
5104a6867,6871
> "Q9Z1X4-1","RefSeq","NP_034691.2","28487382","Data support a model in which NF45, NF90, and NF110 operate in feedback loops that enable them, through both overlapping and independent targets, to help balance the push and pull of pluripotency and differentiation cues."
> "Q9Z1X4-1","RefSeq","NP_034691.2","26289635","Reduction in the expression of YBX1 and ILF3 controls the expression of pluripotency-related genes in ESCs, suggesting their roles in further regulation of the pluripotent state of ESCs."
> "Q9Z1X4-1","RefSeq","NP_034691.2","25918244","NF90-NF45 complex induces centronuclear myopathy through increased dynamin 2 expression by an NF90-NF45-induced reduction of miR-133a expression in vivo."
> "Q9Z1X4-1","RefSeq","NP_034691.2","11438536","Characterization of NFAR-1 and NFAR-2 splice forms in human sample"
> "Q9Z1X4-1","RefSeq","NP_034691.2","7519613","Cloning of human NF90"
5110a6878,6880
> "Q6GQT6-1","RefSeq","NP_001096632.1","29899135","Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis. Publication Status: Online-Only"
> "Q6GQT6-1","RefSeq","NP_001096632.1","29068315","Mechanistic studies show that RNF145 triggers ubiquitination of SCAP on lysine residues within a cytoplasmic loop essential for COPII binding, potentially inhibiting its transport to Golgi and subsequent processing of SREBP-2. Publication Status: Online-Only"
> "Q6GQT6-1","RefSeq","NP_001096632.1","14512514","1,003 genes showed statistically significant increased expression in livers of transgenic SREBP-1a mice, 505 increased in livers of transgenic SREBP-2 mice, and 343 showed decreased expression in Scap-/- livers."
5121,5124c6891,6897
< "Q03146-1","RefSeq","NP_001185760.1","29930002","DDR1 promotes RUNX2 activity and atherosclerotic vascular calcification in diabetes mellitus via phosphoinositide 3-kinase/Akt signaling."
< "Q03146-1","RefSeq","NP_001185760.1","29298894","Data (including data from studies using knockout mice) suggest that Ddr1 plays role in promoting mammary tumor growth; tumor-extrinsic Ddr1 appears to be required for promotion of mammary tumors by interleukin-6."
< "Q03146-1","RefSeq","NP_001185760.1","29483153","The data suggest that the absence of DDR1 provides a growth and adhesion advantage that favors the expansion of basal cells, potentiates fibrosis, and enhances necrosis/hypoxia and basal differentiation of transformed cells to increase their aggression and metastatic potential."
< "Q03146-1","RefSeq","NP_001185760.1","27915093","DDR1 kinase activity is required for regulating collagen IV synthesis."
---
> "P35545-1","RefSeq","NP_032016.1","30710197","MALDI-TOF mass spectrometry fingerprinting revealed that this MNSFbeta adduct consists of an 8.5 kDa MNSFbeta and heat shock protein 60 (HSP60), a mitochondrial protein involved in protein folding."
> "P35545-1","RefSeq","NP_032016.1","27581120","The association of MNSFbeta with HSPA8 may promote RANKL-induced osteoclastogenesis."
> "P35545-1","RefSeq","NP_032016.1","26192119","Collectively, MNSFbeta/FDH complex formation may positively regulate apoptosis in thymocytes."
> "P35545-1","RefSeq","NP_032016.1","26031240","These results demonstrated that a deficiency in MNSFb is associated with pregnancy loss, probably through reduced P53 and/or increased TNFA production at the fetal-maternal interface."
> "P35545-1","RefSeq","NP_032016.1","25180634","CD3/CD28-inducible MNSFbeta-Bcl-G complex may be involved in the regulation of T cell function and survival."
> "Q8C031-1","RefSeq","NP_848840.3","17785411","Axonal NGL-1 transneuronally determines lamina-specific subdendritic segments."
> "Q8C031-1","RefSeq","NP_848840.3","4595443","NGL-1 is most abundant in the striatum and the cerebral cortex--the intermediate and final targets, of thalamocortical axons; surface-bound NGL-1 stimulates, but soluble NGL-1 disrupts, the growth of embryonic thalamic axons."
5128d6900
< "Q8BKC8-1","RefSeq","NP_001280644.1","23541637","Oijbih iuhg iugh uh jkgh uib"
5137c6909,6914
< "Q8R4V1-1","RefSeq","NP_001258340.1","15143214","NFAM1 modulates B cell signaling through its immunoreceptor tyrosine-based activation motif, which regulates B cell development"
---
> "Q8R2Y0-1","RefSeq","NP_079617.2","27783937","These findings identify ABHD6 as a regulator of the counter-regulatory responses to major metabolic shifts."
> "Q8R2Y0-1","RefSeq","NP_079617.2","26997277","Alpha/beta-domain hydrolase-6 suppression averts diet-induced obesity and enhances adipose browning and brown adipose function via PPAR alpha/PPAR gamma activation."
> "Q8R2Y0-1","RefSeq","NP_079617.2","23806692","FAAH but not monoacyl glycerol lipase exerts important protective actions against 2-arachidonoyl glycerol-induced cellular damage."
> "Q8R2Y0-1","RefSeq","NP_079617.2","21665953","Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons."
> "Q8R2Y0-1","RefSeq","NP_079617.2","20657592","ABHD6 is a rate-limiting step of 2-AG signaling"
> "Q8R2Y0-1","RefSeq","NP_079617.2","18096503","Data reveal that 85% of brain 2-arachidonoylglycerol hydrolase activity can be ascribed to monoacylglycerol lipase(MAGL), and the remaining 15% is catalyzed by ABHD6 and ABHD12."
5139a6917,6922
> "Q8K445-1","RefSeq","NP_700435.1","29985171","Results identify clarin-1 as a key organizer of IHC ribbon synapses, and suggest new treatment possibilities for USH3A patients."
> "Q8K445-1","RefSeq","NP_700435.1","26943149","Mutations that are Clrn1-/- biallelic cause visual defects when placed under A/J background."
> "Q8K445-1","RefSeq","NP_700435.1","19414487","Clrn1 is necessary for hair cell function and associated neural activation."
> "Q8K445-1","RefSeq","NP_700435.1","19423712","Clarin-1 has a role in the regulation and homeostasis of actin filaments"
> "Q8K445-1","RefSeq","NP_700435.1","17493778","Clarin-1 ribozyme induced apoptosis of cochlear hair cells and cells of stria vascularis. Suggest role for apoptosis in progressin of Usher syndrome type 3."
> "Q8K445-1","RefSeq","NP_700435.1","12080385","A role for clarin-1 in hair cell and photoreceptor cell synapses, as well as a common pathophysiological pathway for different Usher syndromes"
5141a6925
> "Q5SUD9-1","RefSeq","NP_001008502.2","22958920","Despite increased obesity, glucose tolerance was increased with specific enhanced insulin sensitivity in the adipocytes of Bbs12 knockout mice."
5147a6932
> "Q8BZM0-1","RefSeq","NP_694768.1","18303015","KLHL12 specifically interacts with the D4 polymorphism, thereby building up a Cul3-E3 ligase complex with substrate specificity toward the D4 receptor"
5151a6937
> "P42669-1","RefSeq","NP_033015.1","27651147","Quantitative immunohistochemical assays of the vermal region of the cerebellum and CA1-3 regions of the hippocampus revealed reduced numbers of neurons in general, as well as reduced numbers of Pur-alpha+-immunopositive neurons and dendrites in heterozygous Pur-alpha mice, compared to wild-type littermates"
5154a6941,6945
> "O08650-1","RefSeq","NP_032243.2","29672913","Hyaluronan metabolism via HAS3 does not markedly influence the extracellular matrix structure or function of the Achilles tendon body"
> "Q9WUM3-1","RefSeq","NP_035908.1","25995115","Cor1B, Cof1 and AIP1 work in concert through a temporally ordered pathway to induce highly efficient severing and disassembly of actin filaments. Publication Status: Online-Only"
> "Q9WUM3-1","RefSeq","NP_035908.1","23562652","Wt1 is a transcriptional activator of Coro1b gene."
> "Q9WUM3-1","RefSeq","NP_035908.1","22619279","Suggest that phosphorylation of Coro1B and the subsequent reduced interaction with ARP2/3 complex participate in PDGF-induced VSMC migration, an important step in vascular lesion formation."
> "Q9WUM3-1","RefSeq","NP_035908.1","21844203","Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b."
5164a6956,6959
> "Q8BWY7-1","RefSeq","NP_081492.4","23643525","Data suggest that Zip11 has unique protein sequence and structure features, it functions as a cellular zinc transporter, and its expression is at least partially regulated by zinc via hMTF-1 binding to metal response element sequences of Zip11 promoter."
> "Q3ULA2-1","RefSeq","NP_033901.1","30391586","Investigated beta-TrCP function in Sertoli cells by generating mice with targeted deletion of the beta-TrCP2 gene in Sertoli cells on a background of whole-body beta-TrCP1 knockout. Loss of beta-TrCP in Sertoli cells caused infertility due to a reduction in the number of mature sperm."
> "Q3ULA2-1","RefSeq","NP_033901.1","30619291","Study findings identify beta-TrCP as an important negative regulator for upstream signaling of IkappaBalpha in lipopolysaccharide pathway, and therefore renew the understanding of the roles of beta-TrCP in regulating toll-like receptors inflammatory signaling. Publication Status: Online-Only"
> "Q3ULA2-1","RefSeq","NP_033901.1","30031111","Beta-TrCP was identified as a novel interacting partner of ASK1 that is capable of ubiquitinating and degrading ASK1 through the ubiquitin-proteasome system. These findings suggest that beta-TrCP is capable of suppressing oxidative stress-induced caspase 3-dependent apoptosis through suppression of ASK1."
5166a6962,6977
> "Q9CX83-1","RefSeq","NP_084342.1","28009275","Armcx1 is upregulated after axotomy in a model with robust regeneration. Armcx1 overexpression enhances mitochondrial transport in adult retinal ganglion cells. Armcx1 also promotes both neuronal survival and axon regeneration after injury, and these effects depend on its mitochondrial localization. Erratum:[Neuron. 2017 May 3;94(3):689. PMID: 28472662]"
> "P46096-1","RefSeq","NP_033332.1","29754754","Doc2alpha promoted glutamatergic spontaneous neurotransmitter release, while Doc2beta and syt1 both regulated GABAergic spontaneous neurotransmitter release. Ca(2+) entry via voltage-gated Ca(2+) channels triggered miniature GABA release by activating syt1."
> "Q61147-1","RefSeq","NP_031778.2","30077770","Ceruloplasmin regulates reelin processing, cofilin phosphorylation and neuronal organization in the developing brain."
> "Q61147-1","RefSeq","NP_031778.2","30060949","Results suggest that ablation of hephaestin and ceruloplasmin could lead to severe systemic iron deficiency and local tissue iron overload, which disrupt the whole body iron homeostasis and impact on tissue functions"
> "Q61147-1","RefSeq","NP_031778.2","30182051","HEPH and CP are not essential for intestinal iron absorption but are required for proper systemic iron distribution. Publication Status: Online-Only"
> "Q61147-1","RefSeq","NP_031778.2","15365174","Ceruloplasmin ane hephaestin are critical for CNS iron homeostasis and that loss of Cp and Heph in the mouse leads to age-dependent retinal neurodegeneration."
> "Q61147-1","RefSeq","NP_031778.2","343622","The mouse ceruloplasmin gene has been mapped to chromosome 3. Review article"
> "Q61147-1","RefSeq","NP_031778.2","178338","The mouse ceruloplasmin gene has been mapped to chromosome 3."
> "Q8CGB3-1","RefSeq","NP_082559.1","26269594","Nucling plays an important role in mammary gland involution by regulating NF-kappaB and STAT3 signaling pathways"
> "Q8CGB3-1","RefSeq","NP_082559.1","23624502","Findings indicate that UACA functions as a Rab39A effector in the retinoic acid-induced differentiation of Neuro2A cells."
> "Q8CGB3-1","RefSeq","NP_082559.1","23071121","Data from knockout mice suggest that nucling plays important role in induction of apoptosis in liver/hepatocytes damaged by cytotoxic stressors; nucling acts through modulation of NFkappaB signaling."
> "Q8CGB3-1","RefSeq","NP_082559.1","20702393","Nucling expression is induced by canonical NF-kappaB signalling pathway, whereas Nucling is undergoing proteasome degradation, as well as being cleaved by caspase system under stress conditions"
> "Q8CGB3-1","RefSeq","NP_082559.1","19637241","Nucling deficiency could be a powerful tool to reveal the NF-kappaB-related molecular networks leading to hepatitis and hepatocellular carcinoma development."
> "Q8CGB3-1","RefSeq","NP_082559.1","15271982","Nucling recruits and transports the apoptosome complex during stress-induced apoptosis"
> "Q8CGB3-1","RefSeq","NP_082559.1","14961764","Nucling was shown to interfere with NF-kappaB activation via the nuclear translocation process of NF-kappaB/p65, thus inhibiting the expression of galectin-3."
> "Q8CGB3-1","RefSeq","NP_082559.1","12761289","Expressed specifically in cardiomuscular tissue and up-regulated during cardiac differentiation in the developing embryo"
5168a6980
> "P62700-1","RefSeq","NP_081442.1","27705791","Ypel5 is a negative regulator of IFNB1 production and innate immune responses that interacts functionally and physically with TBK1/IKBKE kinases"
5179a6992,6994
> "Q8BG93-1","RefSeq","NP_766115.1","19735921","These results suggest that the MTH2 deficiency might be one of the causative factors for accelerated aging."
> "Q8BG93-1","RefSeq","NP_766115.1","12767940","MTH2 has a potential to protect the genetic material from the untoward effects of endogenous oxygen radicals; MTH2 could act as an MTH1 redundancy factor [MTH2]"
> "Q5XKN4-1","RefSeq","NP_080641.1","26882284","These results identify a novel role for Jagn1 in regulating proinsulin biosynthesis. Publication Status: Online-Only"
5186a7002
> "Q9QZU4-1","RefSeq","NP_038779.2","21880860","A possible enzyme activity of A-C1"
5196a7013,7015
> "O70291-1","RefSeq","NP_062370.2","27045027","GRK4gamma gene variants (A>65L, A>142V, and A>486V) in mice causes Hypertension, although Salt Sensitivity depends on which is GRK4gamma variant is present. Review article"
> "O70291-1","RefSeq","NP_062370.2","19556343","GRK2 inhibits WNT signaling in osteoblasts"
> "O70291-1","RefSeq","NP_062370.2","15994203","The role of GRK2 in chronic ET-1-induced insulin resistance was investigated."
5208,5210c7027
< "Q3UZ39-1","RefSeq","NP_001104781.1","24690174","Experiments in nude mice demonstrated better response of LRRFIP1 overexpressing glioblastoma multiforme xenografts to teniposide."
< "Q3UZ39-1","RefSeq","NP_001104781.1","20586614","Regulates a rapid type I interferon response"
< "Q3UZ39-1","RefSeq","NP_001104781.1","20453844","LRRFIP1 and its downstream partner beta-catenin constitute another coactivator pathway for IRF3-mediated production of type I interferon"
---
> "Q8BX94-1","RefSeq","NP_653083.2","25759012","The regulation of OSBPL2 by Mir96 was investigated in Mir96 mutant mice. Publication Status: Online-Only"
5219a7037
> "Q8BX39-1","RefSeq","NP_780551.1","16596637","A novel homeobox-containing gene, Eso-1, which is preferentially expressed in ES cells and ovaries, was identified; findings suggest that the novel homeodomain protein, Eso-1, plays a role during oocyte maturation and early embryonic development [Eso-1]"
5223,5228c7041,7046
< "Q3URR7-1","RefSeq","NP_001028597.2","28846095","The pluripotency factor ZSCAN10 is poorly expressed in A-iPSCs and addition of ZSCAN10 to the four Yamanaka factors (OCT4, SOX2, KLF4 and c-MYC) during A-iPSC reprogramming normalizes ROS-glutathione homeostasis and the DNA damage response, and recovers genomic stability. Erratum:[Nat Cell Biol. 2019 Apr;21(4):531-532. PMID: 30643186]"
< "Q3URR7-1","RefSeq","NP_001028597.2","26592664","Our results clearly indicate that Zscan10 is dispensable for the ability of self-renewal and differentiation in ES cells."
< "Q3URR7-1","RefSeq","NP_001028597.2","25111779","A role for Zscan10 in either maintaining progenitor cell subpopulation or impacting on fate choice decisions thereof Erratum:[PLoS One. 2015;10(3):e0118766. PMID: 25741700] Publication Status: Online-Only"
< "Q3URR7-1","RefSeq","NP_001028597.2","22505416","Optimized crystals diffracted to 1.85 A resolution and belonged to space group I422, with unit-cell parameters a = 67.57, c = 87.54 A. A Matthews analysis indicated the presence of one Zfp206SCAN molecule per asymmetric unit"
< "Q3URR7-1","RefSeq","NP_001028597.2","17628018","Zfp206 is an embryonic transcription factor that plays a role in regulating pluripotency of embryonic stem cells."
< "Q3URR7-1","RefSeq","NP_001028597.2","16971461","Zfp206 is a regulator of embryonic stem cell differentiation that controls a set of genes expressed very early in development, most of which themselves appear to be regulators."
---
> "G3XA59-1","RefSeq","NP_001106850.1","28912269","Data (including data from studies using knockout mice) suggest that Garp/Lrrc32 is involved in up-regulation of Tgfb3 and is essential for normal embryogenesis of palate; knockout of Garp causes postnatal lethality, cleft palate, and decreased apoptosis and Smad2 phosphorylation in medial edge epithelial cells of palatal shelf of embryos. (Tgfb3 = transforming growth factor beta 3; Smad2 = MAD homolog protein 2)"
> "G3XA59-1","RefSeq","NP_001106850.1","26246140","These results demonstrate the unexpected presence of GARP on Hepatic stellate cells and its significance in regard to the ability of Hepatic stellate cells to activate latent TGF-beta1 and thereby inhibit T cells."
> "G3XA59-1","RefSeq","NP_001106850.1","23576681","These findings suggest a role for GARP in natural and induced Treg development through activation of bound latent TGF-beta and signaling, which negatively regulates GARP expression on Tregs."
> "G3XA59-1","RefSeq","NP_001106850.1","18628982","GARP is a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression Publication Status: Online-Only"
> "Q9CXF0-1","RefSeq","NP_081828.1","15541637","Levels of mRNA for IDO (indoleamine 2,3-dioxygenase) and kynureninase, enzymes constituting the tryptophan degradation pathway, were found to be upregulated in the skin lesions of atopic dermatitis or psoriasis"
> "Q9DB26-1","RefSeq","NP_758471.1","26970303","Our findings suggest that Phyhd1 and Phyh have distinct roles in mouse leukocytes and Phyhd1 is related to T cell differentiation and/or function of effector T cells."
5240,5243d7057
< "Q9DC40-1","RefSeq","NP_001157133.1","31323273","Upregulating Tel2 expression increases mTOR-mediated cardiomyocyte survival and targeting Tel2 could be another therapeutic strategy against ischemic heart disease"
< "Q9DC40-1","RefSeq","NP_001157133.1","24657168","IP7, formed by IP6K2, binds CK2 to enhance its phosphorylation of the Tti1/Tel2 complex, thereby stabilizing DNA-PKcs and ATM. This process stimulates p53 phosphorylation at serine 15 to activate the cell death program."
< "Q9DC40-1","RefSeq","NP_001157133.1","20864032","The CK2 phospho-dependent interaction between TEL2 and the R2TP complex affects phosphatidylinositol 3-kinase-related kinase functions and is essential for mTOR and SMG1 stability in vivo."
< "Q9DC40-1","RefSeq","NP_001157133.1","18160036","Identify Tel2 as a highly conserved regulator of the stability of PI3K-related protein kinases."
5244a7059,7064
> "Q9WV02-1","RefSeq","NP_035382.1","19403048","These results indicate a major role for SAFB1 in the activation of Srebp-1c through its interaction with RBMX."
> "Q9WV02-1","RefSeq","NP_035382.1","17188681","RBMX may control SREBP-1c expression in mouse liver in response to high-fructose diet."
> "O88673-1","RefSeq","NP_058091.2","29233919","Results suggest DGKalpha aids in modulating the early immune response of adipose tissue following an acute exposure to high-fat diet, possibly through modulation of acute T-cell action"
> "O88673-1","RefSeq","NP_058091.2","28572624","This study shows that diacylglycerol kinase alpha is involved in the vitamin E-induced amelioration of diabetic nephropathy in mice Publication Status: Online-Only"
> "O88673-1","RefSeq","NP_058091.2","27697466","Diacylglycerol kinases alpha and zeta are up-regulated in cancer in cancer, and contribute towards tumor immune evasion and T cells clonal anergy. (Review) Review article"
> "O88673-1","RefSeq","NP_058091.2","26045048","Our studies demonstrate that PKD1/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha effect on MVB secretory traffic."
5253a7074,7076
> "Q8JZM6-1","RefSeq","NP_666088.1","26944478","Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms"
> "Q8JZM6-1","RefSeq","NP_666088.1","26458771","TIFAB loss increases TRAF6 protein and the dynamic range of TLR4 signaling"
> "Q8JZM6-1","RefSeq","NP_666088.1","19470519","Study shows TIFAB is mainly expressed in B cells rather than T cells in the spleen; results suggest TIFAB could act as a negative regulator of TRAF6-induced cellular function such as B cell proliferation and maturation of dendritic cellss & macrophages"
5270,5273c7093
< "O88904-1","RefSeq","NP_001288233.1","30613263","The miR-200c/141 cluster regulated breast cancer stem cells heterogeneity and promoted the epithelial-mesenchymal transformation-like breast cancer stem cells generation, which resulted in increased tumor metastasis and inhibited tumor growth by directly upregulating the target gene homeodomain-interacting protein kinase 1 (HIPK1) and sequential beta-catenin activation. Publication Status: Online-Only"
< "O88904-1","RefSeq","NP_001288233.1","22095214","Therefore, our data confirm that the beta-Catenin signaling plays a dual role in controlling cell proliferation/differentiation in the brain and indicate that Hipk1 is the crucial interactor able to revert the outcome of beta-Catenin signaling in cells."
< "O88904-1","RefSeq","NP_001288233.1","22545114","Despite the expanded marginal zone B cell population in the HIPK1(-/-) mice, the T-independent type 2 humoral response was impaired."
< "O88904-1","RefSeq","NP_001288233.1","12529400","HIPK1 and Daxx collaborate in regulating transcription."
---
> "Q64329-1","RefSeq","NP_034781.2","30381460","Clearance of lung cancer is facilitated by up-regulation of NKG2D, NKp46, and other activating receptors upon exposure to environmental MHCI. Surface expression of the inhibitory receptor Ly49C/I, on the other hand, is down-regulated upon exposure to tumor-bearing tissue."
5274a7095,7098
> "Q9D2H6-1","RefSeq","NP_084496.2","30337366","A mechanism by which the DNA binding-independent activity of Sp2 potentiates genomic loading of Pbx1:Prep1 and Nf-y to composite motifs present in many promoters of highly expressed genes"
> "Q9D2H6-1","RefSeq","NP_084496.2","27191968","SP2 as important factor responsible for higher Cd14 expression and reduced IBD susceptibility mediated by the C3Bir allele. Publication Status: Online-Only"
> "Q9D2H6-1","RefSeq","NP_084496.2","25793500","Our results unveil strikingly different recruitment mechanisms of Sp1/Sp2/Sp3 transcription factor members uncovering an unexpected layer of complexity in their binding to chromatin in vivo. Publication Status: Online-Only"
> "Q9D2H6-1","RefSeq","NP_084496.2","23293287","Sp2 deletion disrupts neurogenesis in the embryonic and postnatal brain."
5276a7101,7104
> "Q91X83-1","RefSeq","NP_598414.1","29749642","The simultaneous downregulation of MAT1A and upregulation of MAT2A are necessary and sufficient for hepatocellular carcinoma metastasis in the process of M1-M2 switch."
> "Q91X83-1","RefSeq","NP_598414.1","26969892","Interplay between MATalpha1, c-Myc, and Maf proteins, and their deregulation during chronic cholestasis may facilitate cholangiocarcinoma oncogenesis Erratum:[Hepatology. 2017 Nov;66(5):1707. PMID: 29053198]"
> "Q91X83-1","RefSeq","NP_598414.1","15033934","MAT1A knockout hepatocytes have more baseline DNA synthesis but no mitogenic response to hepatocyte growth factor. MAT1A-produced SAMe has a major role in ERK signaling & cyclin D1 regulation during liver regeneration & mitogenic signal response."
> "Q91X83-1","RefSeq","NP_598414.1","12060674","Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A"
5279a7108,7112
> "Q921N8-1","RefSeq","NP_062700.2","30975991","Study in GPS2 knockout mice reveals that GPS2 in hepatocytes functionally cooperates with NCOR but not with SMRT to repress PPAR-alpha. These data collectively suggest that GPS2 promotes the progression of fatty liver disease as an epigenome modifier and PPAR-alpha-selective corepressor in hepatocytes. Publication Status: Online-Only"
> "Q921N8-1","RefSeq","NP_062700.2","29767559","GPS2 enhances BK channel activity and its protein expression by reducing ERK1/2 signaling-mediated degradation of the channel."
> "Q921N8-1","RefSeq","NP_062700.2","29499132","These findings, together, reveal an additional layer of regulation of mitochondrial gene transcription, uncover a direct mitochondria-nuclear communication pathway, and indicate that GPS2 retrograde signaling is a key component of the mitochondrial stress response in mammals."
> "Q921N8-1","RefSeq","NP_062700.2","22424771","GPS2 as a molecular guardian required for precise control of inflammatory responses involved in immunity and homeostasis."
> "Q921N8-1","RefSeq","NP_062700.2","20159957","Metabolically important coregulator GPS2 functions as a hitherto unrecognized transrepression mediator of interactions between SUMOylated nuclear receptors and the N-CoR corepressor complex"
5301a7135,7137
> "Q9JMH3-1","RefSeq","NP_056565.1","23750721","Neu2 from thymus exhibited sialidase activity with fetuin at pH 7.0."
> "Q9JMH3-1","RefSeq","NP_056565.1","19632200","30-40% of B and C forms of Neu2 activity was located in the crude membrane-fraction, and hydrolyzed ganglioside effectively, while both soluble fraction showed particular behavior with substrate specificity."
> "Q9JMH3-1","RefSeq","NP_056565.1","16869890","Our data demonstrate that IGF-1-induced myoblast differentiation and hypertrophy are driven, at least in part, by Neu2 upregulation and further support the significant role of cytosolic sialidase in myoblasts."
5303,5307c7139,7141
< "Q8BUE4-1","RefSeq","NP_001034283.1","28732772","The brain-specific isoform of AIF, AIF-2, constitutively expressed in mouse hippocampal HT22 cell lines, where it exerts protective effects against oxygen and glucose deprivation-induced mitochondrial dysfunction, oxidative stress and apoptosis through inhibiting the nuclear translocation of AIF-1."
< "Q8BUE4-1","RefSeq","NP_001034283.1","26689472","4-hydroxy-2-nonenal adduction of AIFm2 shifts the function of AIFm2 from an NADH oxidoreductase to a proapototic protein."
< "Q8BUE4-1","RefSeq","NP_001034283.1","26168492","Aifm2 may function in differentiation of erythroid murine erythroleukemia line cells in vitro."
< "Q8BUE4-1","RefSeq","NP_001034283.1","21366272","Results demonstrate nuclear AIF translocation only in PARG-null TS cells, which demonstrates the presence of AIF-mediated cell death."
< "Q8BUE4-1","RefSeq","NP_001034283.1","16186796","AMID is not required for normal development and p53-mediated tumor suppression."
---
> "Q0VDQ9-1","RefSeq","NP_082738.1","29080672","Fezf1 gene has been identified in the present study as a regulator of female sexual behavior in mice. Regulation of the female sexual behavior could be through the regulation of estrogen receptor alpha expression in the ventromedial nucleus of the hypothalamus, as the expression of this receptor was reduced in mice with downregulated Fezf1."
> "Q0VDQ9-1","RefSeq","NP_082738.1","16971467","These data indicate that Fez and Fezl repress the caudal diencephalon fate in the rostral diencephalon, and ZLI formation probably depends on Fez/Fezl-mediated formation of diencephalon subdivisions."
> "Q0VDQ9-1","RefSeq","NP_082738.1","16540508","Fez is involved in the axonal projection of olfactory sensory neurons."
5322a7157,7158
> "P15947-1","RefSeq","NP_034769.4","25628066","Plasma kallikrein-deficient mice challenged with transient middle cerebral artery occlusion developed significantly smaller brain infarctions."
> "P15947-1","RefSeq","NP_034769.4","24599937","These data do not support a role for the TK-kinin system, protective or deleterious, in the development of insulin resistance and diabetes. Publication Status: Online-Only"
5327a7164,7166
> "Q8C5N3-1","RefSeq","NP_766255.1","28250049","These findings identify subtle but significant alterations in spliceosome structure and function, including dysregulated Cajal bodies and CWC22 overexpression, in diabetic sensory neurons that offer new ideas regarding diabetic sensory neurodegeneration in polyneuropathy."
> "Q8C5N3-1","RefSeq","NP_766255.1","27371833","Authors have reconstructed the origin and history of a 127-kbp segmental duplication, R2d, in the house mouse (Mus musculus). R2d contains a single protein-coding gene, Cwc22 De novo assembly of both the ancestral (R2d1) and the derived (R2d2) copies reveals that they have been subject to nonallelic gene conversion events spanning tens of kilobases."
> "Q8C5N3-1","RefSeq","NP_766255.1","26149421","Study showed major differences in gene copy number in natural populations. CWC22, SFI1, and HJURP are highly conserved genes with the most copy-number variation. They all exhibit population-specific expansion patterns, perhaps for local adaptations."
5341,5343c7180,7183
< "Q501J6-1","RefSeq","NP_001035277.1","29431742","Mechanistic studies reveal that MeXis interacts with and guides promoter binding of the transcriptional coactivator DDX17. The identification of MeXis as a lncRNA modulator of LXR-dependent gene expression expands understanding of the mechanisms underlying cell type-selective actions of nuclear receptors in physiology and disease."
< "Q501J6-1","RefSeq","NP_001035277.1","26947125","Data show that p72/DDX17 specifically interacts with the miR-132 loop sequence and influences the relative ratio of the mature mice miR-212/132 miRNAs. Publication Status: Online-Only"
< "Q501J6-1","RefSeq","NP_001035277.1","22266867","Data indicate that transcriptional coregulator ddx5/ddx17 RNA helicases can simultaneously regulate the transcriptional activity and alternative splicing of NFAT5 transcription factor."
---
> "Q8C7M3-1","RefSeq","NP_444397.2","28701345","Authors demonstrate that tripartite motif protein 9 (TRIM9)-dependent ubiquitination of DCC blocks the interaction with and phosphorylation of FAK."
> "Q8C7M3-1","RefSeq","NP_444397.2","27147649","Adult-born dentate granule cells lacking Trim9 exhibited excessive dendritic arborization and mislocalization of cell bodies in vivo"
> "Q8C7M3-1","RefSeq","NP_444397.2","26702829","A gradient of TRIM9-mediated ubiquitination of VASP creates a filopodial stability gradient during axon turning"
> "Q8C7M3-1","RefSeq","NP_444397.2","11960705","TRIM9 is expressed in the mouse embryonic and adult nervous system"
5353a7194,7195
> "Q6VMN6-1","RefSeq","NP_963909.2","17904108","Female mice deficient of the gene encoding GPR10 develop higher body weight and obesity due to lower energy expenditure."
> "Q6VMN6-1","RefSeq","NP_963909.2","16299503","Altogether, our data identify the PrRP-GPR10 system as a new and potent negative modulator of the opioid system."
5377a7220,7222
> "Q9R0N7-1","RefSeq","NP_775091.2","29957297","Synaptotagmin-7 plays a significant role in the vesicle pool homeostasis and consequently, in the availability of vesicles for synaptic transmission."
> "Q9R0N7-1","RefSeq","NP_775091.2","29771357","While halofuginone did not affect patch-repair-complex key proteins, it further enhanced Syt-7 levels and its spread across the cytosol in dysf-/- myofibers and muscle tissue, and increased its co-localization with lysosomes. Together, the data imply a novel role for halofuginone in membrane-resealing events with Syt-7 possibly taking part in these events."
> "Q9R0N7-1","RefSeq","NP_775091.2","12071850","Identified the conserved alternative splicing events in the spacer domain of Syt VII; also shown that Syt VIIa-GFP is mainly localized in the perinuclear region and tips of neurites (dense-core vesicles), and not in the plasma membrane"
5385a7231,7233
> "Q8C142-1","RefSeq","NP_663529.2","27005486","The combination of Arh and Dab2 is responsible for the majority of adaptor function in LDLR endocytosis and LDLR-mediated cholesterol homeostasis."
> "Q8C142-1","RefSeq","NP_663529.2","15472122","Hepatocytes do not take-up LDL in vivo without ARH protein, but they normally catabolize LDL in vitro. Thus, the requirement of ARH protein for proper functioning of the LDLR is not cell-specific, but rather may depend on the cellular environment."
> "Q8C142-1","RefSeq","NP_663529.2","12746448","Results are consistent with LDL receptor adaptor protein(ARH) playing a critical and specific role in low density lipoprotein receptor endocytosis in the liver"
5397a7246
> "Q0GGX2-1","RefSeq","NP_001334488.1","18849567","The Mm.290718/ZFP541 complex is implicated in chromatin remodeling during spermatogenesis and is renamed SHIP1"
5413a7263,7268
> "A6PWY4-1","RefSeq","NP_084510.2","30655611","Study identifies WD40-repeat protein 76 (WDR76) as one of the HRAS binding proteins using proteomic analyses of hepatocellular carcinomas tissue form human patients and mouse diethylnitrosamine-induced liver carcinogenesis model and demonstrates that WDR76 functions as a tumor suppressor via RAS degradation. Publication Status: Online-Only"
> "Q8BTW9-1","RefSeq","NP_081746.1","28993291","PAK4 crystal structures can be classified into specific conformational groups, and that these groups are associated with previously unobserved hinging motions and an unusual conformation for the kinase hydrophobic core. Our findings therefore indicate that there may be a diversity of kinase hinging motions, and that these may indicate different mechanisms of regulation."
> "Q8BTW9-1","RefSeq","NP_081746.1","28765528","Together, this suggests that PAK4 is dispensable for mouse pancreas development. Publication Status: Online-Only"
> "Q8BTW9-1","RefSeq","NP_081746.1","28261612","PAK4 microparticles may have a role in the ventilation-induced lung injury process"
> "Q8BTW9-1","RefSeq","NP_081746.1","14517283","PAK4 has a role in neural tube development"
> "Q8BTW9-1","RefSeq","NP_081746.1","12529371","PAK4 interacts with KGF receptor and mediate anti-apoptosis effects of KGF on epithelial cells."
5415a7271,7272
> "O70589-1","RefSeq","NP_033936.2","28234597","CASK T740A mutation attenuated the interaction between CASK and TBR1 in the brain. However, CASK T740A mice were generally healthy, without obvious defects in brain morphology. The most dramatic defect among the mutant mice was in extinction of associative memory, though acquisition was normal."
> "O70589-1","RefSeq","NP_033936.2","27036546","Ths data of this study implies that some phenotypic components of CASK heterozygous deletion mutation associated disorders represent systemic manifestation of metabolic stress. Publication Status: Online-Only"
5425,5431c7282,7284
< "O54785-1","RefSeq","NP_034848.1","29319181","The small GTPase RhoA regulated LIMK1/2-cofilin to modulate cytoskeletal dynamics during mouse oocyte meiosis."
< "O54785-1","RefSeq","NP_034848.1","28669900","Results demonstrate an important role for LIMKs in central sensitization and the development of chronic pain"
< "Q9JHG6-1","RefSeq","NP_001075018.1","30389725","Regulator of Calcineurin 1 (RCAN1), a feedback inhibitor of the calcium-activated protein phosphatase calcineurin (CN), acts to suppress two distinctly different mechanisms of non-shivering thermogenesis."
< "Q9JHG6-1","RefSeq","NP_001075018.1","30366682","Study found that RCAN1 RNA expression was suppressed in glomeruli in human diabetic nephropathy, IgA nephropathy, and lupus nephritis, and in mouse models of HIV-associated nephropathy and diabetic nephropathy. Findings suggest that epigenetic suppression of RCAN1 aggravates podocyte injury in the setting of HIV infection and diabetic nephropathy."
< "Q9JHG6-1","RefSeq","NP_001075018.1","30442942","Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture. Publication Status: Online-Only"
< "Q9JHG6-1","RefSeq","NP_001075018.1","30139658","This study demonstrated that Rcan1 is regulated by oxidative stress and identified RCAN1 as a potential diagnostic marker of acute pancreatitis."
< "Q9JHG6-1","RefSeq","NP_001075018.1","29799862","These findings demonstrate a novel regulatory role of RCAN1 in TLR signaling, which differentially regulates MyD88 and TRIF pathways. Publication Status: Online-Only"
---
> "O09053-1","RefSeq","NP_035851.3","29494634","These results suggest that a great number of endoplasmic reticulum (ER) gene products are regulated at the post-transcriptional level in the liver of Wrn mutant mice exhibiting an ER stress response. Publication Status: Online-Only"
> "O09053-1","RefSeq","NP_035851.3","26521679","A mislocalization of the Wrn mutant protein in the liver endoplasmic reticulum fraction increased oxidative stress in that cellular compartment. Vitamin C reversed this oxidative stress."
> "O09053-1","RefSeq","NP_035851.3","26447695","The deleterious effects of the helicase-deficient Wrn protein are mediated by the dysfunction of several cellular organelles. Publication Status: Online-Only"
5435,5436d7287
< "Q61730-1","RefSeq","NP_032390.1","25449578","We conclude that neuron-specific AcPb plays a critical role in host defenses and sleep homeostasis."
< "Q61730-1","RefSeq","NP_032390.1","25908590","These results thus reveal the decoding mechanism of splice-insert signaling codes for synaptic differentiation induced by trans-synaptic adhesion between PTPdelta and IL1RAPL1/IL-1RAcP. Publication Status: Online-Only"
5441a7293,7294
> "P50615-1","RefSeq","NP_033900.1","19234306","Results suggest that ANA is a suppressor of ectopic bone formation induced by bone morphogenetic proteins, and this inhibitory ANA activity is a part of the negative feedback regulation of BMP function."
> "P50615-1","RefSeq","NP_033900.1","19068083","Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma."
5444a7298,7302
> "Q80T21-1","RefSeq","NP_659148.2","26405179","The first ADAMTSL4 mouse model, tvrm267, bearing a nonsense mutation in Adamtsl4"
> "Q80T21-1","RefSeq","NP_659148.2","20637190","O-fucose modification of thrombospondin type 1 repeats was essential for modulation of growth factor signaling during gastrulation."
> "Q80UP8-1","RefSeq","NP_035524.2","30041812","Thus, PiT-2 in vascular smooth muscle cells protects against phosphate-induced vascular calcification."
> "Q80UP8-1","RefSeq","NP_035524.2","29803831","Loss of Slc20a2 expression is associated with Retarded Growth and brain calcification."
> "Q80UP8-1","RefSeq","NP_035524.2","29551636","PiT2 is necessary for phosphate-dependent secretion of Fgf23, independently from possible endocrine regulatory loops."
5459a7318,7319
> "Q9QYR6-1","RefSeq","NP_115769.1","28701415","Structure of the PSD-95/MAP1A complex reveals a unique target recognition mode of the MAGUK GK domain. Publication Status: Online-Only"
> "Q9QYR6-1","RefSeq","NP_115769.1","26609151","Mutant mice lacking MAP1A exhibited reduced synaptic plasticity."
5475a7336,7340
> "Q8BGT1-1","RefSeq","NP_848469.1","28475893","Mice with deletions of FLRT1 and FLRT3 adhesion molecules develop macroscopic sulci with preserved layered organization and radial glial morphology. Cortex folding in these mutants does not require progenitor cell amplification but is dependent on changes in neuron migration."
> "Q8BGT1-1","RefSeq","NP_848469.1","26235031","The crystal structure of the OLF/FLRT3 complex shows that LPHN3-OLF in the closed state binds with high affinity to the concave face of FLRT3-LRR with a combination of hydrophobic and charged residues."
> "Q8BGT1-1","RefSeq","NP_848469.1","18448090","Data demonstrate that FLRT3 plays a key role in controlling cell adhesion and tissue morphogenesis in the developing mouse embryo."
> "Q8BGT1-1","RefSeq","NP_848469.1","16872596","FLRT3 has an expression pattern during somite development"
> "P58044-1","RefSeq","NP_663335.2","14629038","Only one of the two isoforms (IDI1) is highly conserved, ubiquitously expressed and most likely responsible for housekeeping isomerase activity"
5483a7349
> "Q8VHF2-1","RefSeq","NP_082345.1","12589428","MUCDHL genes are biallelically expressed in multiple fetal and adult tissues both in humans and in mice"
5491a7358
> "Q9D0N7-1","RefSeq","NP_082359.1","30423293","CHAF1B is required for normal hematopoiesis while its overexpression promotes leukemia."
5494,5496c7361,7362
< "Q61210-1","RefSeq","NP_001123624.1","29130930","Data highlight the importance of Arhgef1 in cardiovascular disease and suggest targeting Arhgef1 as a potential therapeutic strategy against atherosclerosis."
< "Q61210-1","RefSeq","NP_001123624.1","27923664","Arhgef1 controls the process of neurite formation in newborn cortical neurons derived from neural progenitor cells"
< "Q61210-1","RefSeq","NP_001123624.1","27489999","These findings reveal that Arhgef1 functions as a negative regulator of neurite outgrowth through regulating RhoA-cofilin pathway and actin dynamics."
---
> "Q9JIW5-1","RefSeq","NP_062356.3","19419974","Smad8 loss of function resulted in changes in pulmonary arteries including medial thickening and smooth muscle hyperplasia observed in patients with pulmonary artery hypertension."
> "Q9JIW5-1","RefSeq","NP_062356.3","11850197","Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney."
5509a7376,7378
> "Q9CZA5-1","RefSeq","NP_082601.1","21172456","Sizn1 is expressed by Cajal-Retzius neurons of the dorsal forebrain, beginning in their progenitor zones"
> "Q9CZA5-1","RefSeq","NP_082601.1","19578717","ZCCHC12 enhanced the transcriptional activities of activator protein 1 (AP-1) and cAMP response element binding protein (CREB) as a coactivator"
> "Q8C4V1-1","RefSeq","NP_666273.1","21911940","Increased levels of active Rac1 and Cdc42 were measured in Arhgap24 knockdown experiments, which influenced podocyte cell shape and membrane dynamics."
5516,5520c7385,7389
< "Q99MK9-1","RefSeq","NP_001230677.1","31086178","Study show that hypoxia promotes stabilization of RASSF1A through NOX-1- and protein kinase C- dependent phosphorylation. HIF-1alpha activates RASSF1A transcription via HIF-binding sites in the RASSF1A promoter region. RASSF1A binds to HIF-1alpha, blocks its prolyl-hydroxylation and proteasomal degradation. Study concludes that RASSF1A-HIF-1alpha forms a feedforward loop driving hypoxia signaling in pulmonary hypertens... Publication Status: Online-Only"
< "Q99MK9-1","RefSeq","NP_001230677.1","29735543","The authors found that haploinsufficiency of Rassf1a was sufficient to dramatically enhance the tumorigenicity of K-Ras in the system."
< "Q99MK9-1","RefSeq","NP_001230677.1","29382819","RASSF1A is expressed in differentiating stem cells.RASSF1A promotes YAP and p73 binding to differentiation related genes.RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73. Publication Status: Online-Only"
< "Q99MK9-1","RefSeq","NP_001230677.1","27765918","Beta-catenin was predominantly associated with Na+/H+ exchanger regulating factor 1 (NHERF1) in a dynamic context and an increase of its oncogenic function through RAS-association domain family 1, isoform A (RASSF1A) inactivation in liver metastases."
< "Q99MK9-1","RefSeq","NP_001230677.1","15665283","Deletion of this gene increases cancer susceptibility in mice."
---
> "P28230-1","RefSeq","NP_032150.2","30325069","This study demonstrated that loss of Cx32 promote inflammation and increase vulnerability of myelinated fibers, as shown in Cx32KO mice following EAE induction."
> "P28230-1","RefSeq","NP_032150.2","29728112","Cx32 mediated reactive oxygen species/endoplasmic reticulum stress/apoptosis signal pathway activation played an important part in Ischemia-reperfusion-induced acute kidney injury. Publication Status: Online-Only"
> "P28230-1","RefSeq","NP_032150.2","28687253","Blocking of connexin32 or connexin43 hemichannels decreased serum levels of pro-inflammatory cytokines, and reduced acetaminophen-induced liver injury."
> "Q8K0U4-1","RefSeq","NP_780408.1","29530582","Findings suggest that HSPA12A expression encodes a critical novel prosurvival pathway during ischaemic stroke."
> "Q8K0U4-1","RefSeq","NP_780408.1","12552099","HSPA12A and HSPA12B may play roles in genetic susceptibility to atherosclerosis"
5534a7404,7406
> "Q8VDF2-1","RefSeq","NP_035061.3","29859850","Findings suggest that Np95 plays an essential role in proliferation and differentiation of aNS/PCs through the regulation of tumor suppressor gene expression in adult neurogenesis."
> "Q8VDF2-1","RefSeq","NP_035061.3","31024001","During limb development in mouse embryos, Uhrf1 is expressed in the undifferentiated autopodial mesoderm and in subsequent stages, expression becomes restricted to the interdigital mesoderm. By day 14 post coitum, interdigit regression is almost accomplished and Uhrf gene expression become restricted to zones of the joint formation. Publication Status: Online-Only"
> "Q8VDF2-1","RefSeq","NP_035061.3","29968706","Study report that Uhrf1 forms a complex with the active trithorax group, the Setd1a/COMPASS complex, to maintain bivalent histone marks, particularly those associated with neuroectoderm and mesoderm specification. Publication Status: Online-Only"
5540a7413,7416
> "O08807-1","RefSeq","NP_058044.1","30149550","These features indicate that PRDX4 plays an important role in protecting against liver injury following BDL and might be a promising therapeutic modality for cholestatic diseases. Publication Status: Online-Only"
> "O08807-1","RefSeq","NP_058044.1","30050648","DKO mice spontaneously develop severe liver failure at a relatively young stage, they have the potential for use as a model for hepatic disorders and for testing other potential treatments. Publication Status: Online-Only"
> "O08807-1","RefSeq","NP_058044.1","27035833","Data provide the first evidence of the beneficial effects of PRDX4 on intestinal function in the reduction of the severity of NAFLD, by ameliorating oxidative stress-induced local and systemic injury Publication Status: Online-Only"
> "O08807-1","RefSeq","NP_058044.1","26917265","Prdx4 expression was closely related to follicular development and has aprominent role in protecting human and mouse granulosa cells from reactive oxygen species damage."
5547a7424,7429
> "P40124-1","RefSeq","NP_031624.2","30962575","We purified an INF2 inhibitor from mouse brain tissue, and identified it as a complex of lysine-acetylated actin (KAc-actin) and cyclase-associated protein (CAP). Inhibition of INF2 by CAP-KAc-actin is dependent on the INF2 diaphanous inhibitory domain (DID)."
> "P40124-1","RefSeq","NP_031624.2","29760438","The structural basis of actin monomer re-charging by CAP1 protein has been reported. Publication Status: Online-Only"
> "P40124-1","RefSeq","NP_031624.2","25315833","Phosphorylation regulates CAP1 function through association with cofilin and actin in order to control the actin cytoskeleton."
> "P40124-1","RefSeq","NP_031624.2","25228691","Lkj o hpoi oihl hip oihpo ih"
> "P40124-1","RefSeq","NP_031624.2","23184938","Study provides evidence that catalyzing nucleotide exchange on actin monomers via the beta-sheet domain is the most highly conserved function of CAPs from mammals to apicomplexan parasites."
> "P40124-1","RefSeq","NP_031624.2","15004221","CAP1 is widely expressed in mouse nonmuscle cells and promotes cofilin-induced actin dynamics."
5549,5552d7430
< "Q9QYY8-1","RefSeq","NP_001156342.1","30213879","Two isoforms of spastin harboring the same missense mutation bind and bundle different subsets of microtubules. Publication Status: Online-Only"
< "Q9QYY8-1","RefSeq","NP_001156342.1","28392418","Spastin regulates VAMP7-containing vesicles trafficking in cortical neurons."
< "Q9QYY8-1","RefSeq","NP_001156342.1","27773584","Axon branch loss at the developing mouse neuromuscular junction is mediated by branch-specific microtubule severing, mediated by the microtubule-severing enzyme spastin."
< "Q9QYY8-1","RefSeq","NP_001156342.1","24065130","Spastin is recruited by microtubules polyglutamylation, induced by Tau missorting triggered translocalization of TTLL6 (Tubulin-Tyrosine-Ligase-Like-6) into dendrites"
5563a7442,7444
> "P97391-1","RefSeq","NP_035240.3","29346348","Macrophage-associated Pla2g5 contributes significantly to type-2 immunity through regulation of IL-33 induction and free fatty acids-driven group 2 innate lymphoid cell activation"
> "P97391-1","RefSeq","NP_035240.3","28825176","Deficiency of GV sPLA2 results in diminished glucose-stimulated insulin secretion in isolated pancreatic beta-cells"
> "P97391-1","RefSeq","NP_035240.3","26820468","GV sPLA2 is involved in the maintenance of tubular cell function and integrity, promoting sodium retention through increased cortical (Na+ + K+)-ATPase expression and activity. Publication Status: Online-Only"
5589a7471
> "Q9JJV0-1","RefSeq","NP_067326.1","30646012","The current study shows for the first time that two highly expressed lens crystallin genes, Cryba4 and Crybb1, can be simultaneously transcribed from adjacent bidirectional promoters and do not show nuclear accumulation."
5603a7486,7487
> "Q9EQQ4-1","RefSeq","NP_444337.3","27500489","GPR45 is a regulator of POMC signaling and energy expenditure, which suggests that it may be a potential intervention target to combat obesity"
> "Q9EQQ4-1","RefSeq","NP_444337.3","22262891","Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation"
5627,5638c7511,7519
< "Q7TNT2-1","RefSeq","NP_001334445.1","30372477","Far2 null mice provide further support for a central role for chronic sebadenitis in the development of a number of cicatricial alopecias. The Meibomian and clitoral glands (modified sebaceous glands) showed ducts dilated to various degrees that were associated with mild changes in the sebocytes as seen in the truncal skin. Publication Status: Online-Only"
< "Q7TNT2-1","RefSeq","NP_001334445.1","29652635","Results indicate fatty acyl CoA reductase 2 FAR2's role in the development of mesangial matrix expansion and chronic kidney disease."
< "Q7TNT2-1","RefSeq","NP_001334445.1","24009241","Mouse strains with mesangial matrix expansion contain a 9-bp sequence in the 5' untranslated region of Far2 that is absent in most of the strains without it."
< "Q7TNT2-1","RefSeq","NP_001334445.1","15220349","Wax monoester synthesis in mammals involves a two step biosynthetic pathway catalyzed by fatty acyl-CoA reductase and wax synthase enzymes"
< "Q7TNT2-1","RefSeq","NP_001334445.1","15220348","Fatty alcohol synthesis in mammals is accomplished by two fatty acyl-CoA reductase isozymes that are expressed at high levels in tissues known to synthesize wax monoesters and ether lipids"
< "Q8CI15-1","RefSeq","NP_001165943.1","29673590","The cell division gene PCNA was significantly overexpressed in SK2(-/-) cells, suggesting a cross regulation between sphingosine kinases and Ceramide glucosyltransferase."
< "Q8CI15-1","RefSeq","NP_001165943.1","17643421","Sphingosine kinase 1 is a component of the copper-dependent FGF1 release pathway."
< "Q8CI15-1","RefSeq","NP_001165943.1","16623665","Results suggest that export of Sphk-1a isoform occurs under physiological conditions and may contribute to the establishment of the vascular S1P gradient."
< "Q8CI15-1","RefSeq","NP_001165943.1","16368679","SPHK1a and SPHK1b differ in enzymatic traits including stability, localization, modification, and oligomerization."
< "Q8CI15-1","RefSeq","NP_001165943.1","12391145","Data describe a novel mechanism by which vascular endothelial growth factor induces DNA synthesis in a pathway where sphingosine kinase mediates signaling from protein kinase C to Ras in a manner independent of Ras-guanine nucleotide exchange factor."
< "P19973-1","RefSeq","NP_001129543.1","27555448","Regulation of O-GlcNAcylation and phosphorylation of lymphocyte-specific protein-1 (Lsp1) is a key switch that triggers apoptosis in activated B cells. O-GlcNAcylation at S209 of Lsp1 is a prerequisite for the recruitment of its kinase, PKC-beta1, to induce S243 phosphorylation. Publication Status: Online-Only"
< "P19973-1","RefSeq","NP_001129543.1","26554018","The importance of LSP1 Copy number variations and LSP1 insufficiency in the pathogenesis of rheumatoid arthritis, is reported."
---
> "Q2Q5T5-1","RefSeq","NP_001170941.1","29581287","Genetic deletion of Myomixer in satellite cells abolishes satellite cell fusion and prevents muscle regeneration, resulting in severe muscle degeneration after injury."
> "Q2Q5T5-1","RefSeq","NP_001170941.1","28569755","Myomerger is a fundamental myoblast fusion protein with roles in skeletal muscle development Publication Status: Online-Only"
> "Q2Q5T5-1","RefSeq","NP_001170941.1","28569745","Minion is a novel microprotein required for muscle development Publication Status: Online-Only"
> "Q2Q5T5-1","RefSeq","NP_001170941.1","28386024","The Myomixer-Myomaker pair controls the critical step in myofiber formation during muscle development."
> "Q2Q5T5-1","RefSeq","NP_001170941.1","28637957","Gm7325, as a novel MyoD-target gene, is specifically induced in activated satellite cells, and may have an important role in skeletal myogenesis."
> "Q2Q5T5-1","RefSeq","NP_001170941.1","16331322","The expression of ESGP is consistent with the expression of Oct-4 during embryonic development.Forced expression of ESGP is not indispensable for the effect of Oct-4 on ES cell self-renewal, and does not affect the differentiation to three germ layers."
> "Q62393-1","RefSeq","NP_033438.1","28798933","The important roles of TPD52 and TPD54, which work oppositely, in the terminal differentiation of chondrocytes during endochondral ossification."
> "Q62393-1","RefSeq","NP_033438.1","26183179","Findings uncover a new isoform-specific role for TPD52 in promoting intracellular lipid storage, which might be relevant to TPD52 overexpression in cancer."
> "Q62393-1","RefSeq","NP_033438.1","17314271","Together, these data suggest that mD52 expression in 3T3 cells initiated cellular transformation, tumorigenesis, and progression to metastasis."
5646,5647d7526
< "Q925H0-1","RefSeq","NP_001029185.1","30074209","ASICs promote the inflammatory response and apoptosis of RAW 264.7 cells."
< "Q925H0-1","RefSeq","NP_001029185.1","27402850","The potentiation of ASICs by quinine depends on the presence of the ASIC1a, ASIC2a subunits, but not ASIC1b, ASIC3 subunits. Furthermore, we have determined the amino acids in ASIC1a that are involved in the modulation of ASICs by pHi."
5653a7533,7536
> "P20029-1","RefSeq","NP_071705.3","31266968","Knockdown of OTUD3 results in a decrease in the level of GRP78 protein, suppression of cell growth and migration, and tumorigenesis in lung cancer. Publication Status: Online-Only"
> "P20029-1","RefSeq","NP_071705.3","30787103","Observations provide a mechanism for the sequential involvement of BiP and Grp94 in client folding where the conformation of BiP provides the signal for the subsequent recruitment of Grp94."
> "P20029-1","RefSeq","NP_071705.3","30573681","These results indicated a novel GRP78-dependent localization and specific function of IL-34 in FL-Y cells related to monocytic cell differentiation."
> "P20029-1","RefSeq","NP_071705.3","30567393","Tunicamycin (TM) treatment significantly increased mRNA levels of CHOP and GRP78, and induced lipid accumulation in the liver. Lipid peroxidation in the liver tissue also increased from TM treatment (CON vs. TM; 3.0 +/- 1.8 vs. 11.1 +/- 0.8 nmol MDA/g liver, p < 0.001), which reflects an imbalance between the generation of reactive substances and antioxidant capacity Publication Status: Online-Only"
5661d7543
< "P26618-1","RefSeq","NP_001076785.1","27894125","Polyadenylation of a PDGFRalpha intron in resident stem cells attenuates muscle fibrosis"
5665,5671c7547,7551
< "Q7TSD4-1","RefSeq","NP_001017433.1","24361585","Spatial, through its transport by Kif17, is crucial for neuronal polarization."
< "Q7TSD4-1","RefSeq","NP_001017433.1","20937703","Tbata modulates thymus function by regulating stromal cell proliferation via the Nedd8 pathway."
< "Q7TSD4-1","RefSeq","NP_001017433.1","19918778","Data show that Spatial expression is independent of thymocyte-derived signals during thymus organogenesis."
< "Q7TSD4-1","RefSeq","NP_001017433.1","17961552","These findings suggest that Spatial may play a role in neuronal morphogenesis and synaptic plasticity through its interaction with the kinesin motor KIF17 in dendrites."
< "Q7TSD4-1","RefSeq","NP_001017433.1","17196196","Together, these findings imply a function of Spatial in spermatid differentiation as a new cargo of kinesin KIF17b, in a microtubule-dependent mechanism specific to the manchette and the principal piece of the sperm tail."
< "Q7TSD4-1","RefSeq","NP_001017433.1","15236666","A new short thymus isoform, Spatial-beta, differs from other isoforms by an additional alternative exon of 69 bases. This new exon encodes an interesting proline-rich signature that could confer to the 34 kDa Spatial-beta protein a particular function. Publication Status: Online-Only"
< "Q7TSD4-1","RefSeq","NP_001017433.1","11196687","Provides evidence for non-AUG translation initiation site"
---
> "Q91WE1-1","RefSeq","NP_081188.1","26115702","SNX15 regulates the recycling of APP to cell surface and, thus, its processing for Abeta generation."
> "Q9WUB4-1","RefSeq","NP_035852.1","23455152","Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit."
> "Q8BUH8-1","RefSeq","NP_079759.2","28315713","SENP7 programs zygotic DNA repair and spindle assembly to facilitate maternal-to-zygotic transition.  SENP7 intervenes epigenetic scenarios of histone H3 during oocyte and embryo development."
> "Q8BUH8-1","RefSeq","NP_079759.2","27039038","Senp7 is transiently activated at early stages of neuronal differentiation."
> "Q8BUH8-1","RefSeq","NP_079759.2","22388734","Depletion of Senp7 delocalizes HP1 alpha from pericentric heterochromatin without affecting H3K9me3 levels. Publication Status: Online-Only"
5674a7555
> "Q9EQY5-1","RefSeq","NP_109632.2","12376530","SR-A and CD36 are responsible for the preponderance of modified LDL uptake in macrophages and that other scavenger receptors do not compensate for their absence"
5678a7560,7563
> "P42230-1","RefSeq","NP_035618.1","30664665","It has been shown that T-cell receptors-activated post-translational modification by O-linked N-Acetylglucosamine stabilizes FOXP3 and activates STAT5, thus integrating these critical signaling pathways. Publication Status: Online-Only"
> "P42230-1","RefSeq","NP_035618.1","30662340","STAT5 activation is associated with transcription of cell cycle regulators such as cyclin kinase inhibitor P21 and anti-apoptotic genes as BCL-2 genes. Publication Status: Online-Only"
> "P42230-1","RefSeq","NP_035618.1","30571750","In males, castration significantly reduced pSTAT5 immunoreactivity in some structures, including the paraventricular and ventromedial hypothalamic nuclei and the septofimbrial region, thus indicating a region-specific regulatory role of testosterone over central prolactin signalling. Publication Status: Online-Only"
> "P42230-1","RefSeq","NP_035618.1","29921584","Tollip differentially modulates HIF1alpha and STAT5 expression in fibroblasts."
5680a7566,7569
> "Q8BTH8-1","RefSeq","NP_775277.2","16014721","CK1 regulates fast synaptic transmission by glutamate in brain. Activation of CK1 decreases NMDA receptor activity in the striatum via activation by this kinase of protein phosphatase 1 &/or 2A & increased dephosphorylation of NMDA receptors."
> "Q99246-2","RefSeq","NP_083257.2","29733375","Data show that editing of Cav1.3 calcium channel (CaV1.3) was potently inhibited by serine/arginine-rich splicing factor 9 (SRSF9)."
> "Q99246-2","RefSeq","NP_083257.2","30001160","The molecular interactions engaging D4 in VSD IV contribute to voltage-sensing in all examined CaV1.3 channel, however its striking role in regulating the gating properties by alternative splicing appears to be a unique property of the skeletal muscle CaV1.1 channel."
> "Q9QUN5-1","RefSeq","NP_038794.1","28576872","Analysis of the biology of the Prl3c1 gene has provided insight into a previously unappreciated homeostatic setpoint control system programming testicular growth and function."
5686,5691c7575,7576
< "Q14BU0-1","RefSeq","NP_001107030.1","29720262","Upper zone of growth plate and cartilage matrix associated protein (Ucma) physically interacted with a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) protein (ADAMTS5) and blocked its aggrecanase activity in chondrocyte cultures. Publication Status: Online-Only"
< "Q14BU0-1","RefSeq","NP_001107030.1","29563538","Study using Ucma/GRP-/- and ApoE-/- mice showed for the first-time evidence of a direct interaction between Ucma/GRP and Bmp-2. These results demonstrate an important role of Ucma/GRP in regulating osteo/chondrogenic differentiation and phosphate-induced mineralisation of vascular smooth muscle cells. Publication Status: Online-Only"
< "Q14BU0-1","RefSeq","NP_001107030.1","24867294","Data suggest that a novel splice variant of GRP is expressed in cartilage and other tissues (i.e. GRP-F7); GRP-F1 is predominant splice variant expressed in adult tissues."
< "Q14BU0-1","RefSeq","NP_001107030.1","19819238","Four alternative splicing variants derived from the mouse Ucma/GRP gene in chondrocytes were identified and their expression and subcellular localization during chondrogenesis was determined."
< "Q14BU0-1","RefSeq","NP_001107030.1","18156182","Ucma may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells"
< "Q14BU0-1","RefSeq","NP_001107030.1","17707622","The present data strongly suggest an important function of Ucma in the early phase of chondrocyte differentiation."
---
> "Q9Z104-1","RefSeq","NP_034570.1","22570500","Our data uncover a mechanism of regulation of the LSD1-CoREST complex and provide a molecular explanation for the antagonism between Braf35 and iBraf in neuronal differentiation."
> "Q9Z104-1","RefSeq","NP_034570.1","21606163","Hmg20b acts as an inhibitor of erythroid differentiation, through the down-regulation of genes involved in differentiation"
5693a7579
> "Q6PA06-1","RefSeq","NP_835151.2","27669642","Endoplasmic reticulum morphology is markedly disrupted in ATL1, ATL2, and ATL3 knockout cells."
5712,5714c7598,7599
< "Q8C6K9-1","RefSeq","NP_001096077.1","21477648","Immunoelectron microscopy of skeletal muscle localized the collagen VI alpha 6 chain to the reticular lamina of muscle fibers"
< "Q8C6K9-1","RefSeq","NP_001096077.1","18400749","Discovery of three additional collagen VI chains doubles the collagen VI family and adds a layer of complexity to collagen VI assembly and function in the extracellular matrix"
< "Q8C6K9-1","RefSeq","NP_001096077.1","18276594","Analysis of collagen VI chains alpha4, alpha5, and alpha6with high homology to the alpha3 chain"
---
> "Q9D270-1","RefSeq","NP_080923.2","28838985","Results suggest an important role of ZDHHC21 in mediating gut hyperpermeability resulting from thermal injury."
> "Q9D270-1","RefSeq","NP_080923.2","26715683","ZDHHC21 F233Delta diminishes the function of vascular alpha1 adrenergic receptors, leading to reduced vascular tone, which manifests in vivo as hypotension and tachycardia."
5728a7614,7619
> "P49183-1","RefSeq","NP_034191.3","29191910","DNase1 and DNase1-like 3 are independently expressed and thus provide dual host protection against deleterious effects of intravascular neutrophil extracellular traps."
> "Q8BUE4-1","RefSeq","NP_835159.1","28732772","The brain-specific isoform of AIF, AIF-2, constitutively expressed in mouse hippocampal HT22 cell lines, where it exerts protective effects against oxygen and glucose deprivation-induced mitochondrial dysfunction, oxidative stress and apoptosis through inhibiting the nuclear translocation of AIF-1."
> "Q8BUE4-1","RefSeq","NP_835159.1","26689472","4-hydroxy-2-nonenal adduction of AIFm2 shifts the function of AIFm2 from an NADH oxidoreductase to a proapototic protein."
> "Q8BUE4-1","RefSeq","NP_835159.1","26168492","Aifm2 may function in differentiation of erythroid murine erythroleukemia line cells in vitro."
> "Q8BUE4-1","RefSeq","NP_835159.1","21366272","Results demonstrate nuclear AIF translocation only in PARG-null TS cells, which demonstrates the presence of AIF-mediated cell death."
> "Q8BUE4-1","RefSeq","NP_835159.1","16186796","AMID is not required for normal development and p53-mediated tumor suppression."
5733,5736c7624,7628
< "P42227-1","RefSeq","NP_998824.1","31177110","Study provides evidence that Stat3 activity is required for HC11 mammary epithelial cell differentiation."
< "P42227-1","RefSeq","NP_998824.1","31036001","Studied effect of Papaver nudicaule extract on reduction of inflammation through inactivating NF-kappaB and signal transducer and activator of transcription 3 (STAT3) in lipopolysaccharide treated RAW264.7 cells. Publication Status: Online-Only"
< "P42227-1","RefSeq","NP_998824.1","30996264","Study identified Fam3a, a cytokine-like protein, as a major Stat3 downstream effector in muscle stem cells and demonstrated that Fam3a is required for muscle stem cell commitment and skeletal muscle development. These findings indicate that Fam3a is a Stat3-regulated secreted factor that promotes muscle stem cell oxidative metabolism and differentiation. Publication Status: Online-Only"
< "P42227-1","RefSeq","NP_998824.1","31026806","Model suggests a negative role for STAT3 in regulating class switching of the GC B cells from the IgG1 to the IgE producing state. Publication Status: Online-Only"
---
> "Q00731-1","RefSeq","NP_033531.3","30974834","Findings demonstrate that COX-2 activity is important in the recruitment of VEGF-secreting Ly6C(high) monocytes, which are involved in VILI pathogenesis, and indicate that the suppression of COX-2 activity might be a useful strategy in mitigating ventilator-induced lung injury. Publication Status: Online-Only"
> "O70494-1","RefSeq","NP_001091895.1","28359915","Sp3 binds and activates the FGFR4 promoter."
> "O70494-1","RefSeq","NP_001091895.1","28522827","Sp3 interacts with the STING promoter and activates the basal transcription of the STING gene. Publication Status: Online-Only"
> "O70494-1","RefSeq","NP_001091895.1","27143785","Dp71 expression in hepatic cells is carried out, in part, by YY1-, Sp1- and Sp3-mediated transcription from the Dp71 promoter."
> "O70494-1","RefSeq","NP_001091895.1","11472836","Sp3 is an essential transcription factor for late bone development."
5754a7647,7649
> "Q91X88-1","RefSeq","NP_084062.2","25085363","Findings suggest that PomGnT1 promotes GBM progression via activation of beta-catenin and may serve as a prognostic factor for glioma patient survival as well as a novel molecular target for anticancer therapy in malignant glioma."
> "Q91X88-1","RefSeq","NP_084062.2","17034757","From these findings, we propose that fukutin forms a complex with POMGnT1 and may modulate its enzymatic activity."
> "Q91X88-1","RefSeq","NP_084062.2","16458488","The present study provides the first genetic animal model to further dissect the roles of POMGnT1 in MEB disease."
5755a7651,7653
> "P19324-1","RefSeq","NP_033955.2","30541925","Increased Hsp47 expression is associated with collagen-related disorders such as fibrosis, characterized by abnormal collagen accumulation, highlighting Hsp47's potential as a clinically relevant therapeutic target. Review article"
> "P19324-1","RefSeq","NP_033955.2","29512284","HSP47 on the platelet surface interacts with collagen, stabilizes platelet adhesion and increases collagen-mediated signalling to mediate thrombus formation and hemostasis."
> "P19324-1","RefSeq","NP_033955.2","29363541","These results highlight a cascade of fibrosis in chronic GVHD; macrophage production of transforming growth factor beta mediates fibroblast differentiation to HSP47(+) myofibroblasts that produce collagen. VA-lip HSP47 represent a novel strategy to modulate fibrosis in chronic GVHD by targeting HSP47(+) myofibroblasts without inducing immunosuppression."
5757a7656,7663
> "Q3V1V3-1","RefSeq","NP_001074559.1","15660422","The Rattus rattus ABT1-associated protein formed a complex with ABT1 and suppressed activation of Pol II-directed transcription in mammalian cells. It binds and negatively regulates ABT1."
> "Q8VHL0-1","RefSeq","NP_082398.1","27914708","Functional deficiency of all UTs caused a urea-selective urine-concentrating defect with little physiological abnormality in extrarenal organs."
> "Q8VHL0-1","RefSeq","NP_082398.1","27091563","These results demonstrate that the descending thin limb (DTL) of the intermediate loop is composed of type I epithelium and expresses both UT-A2. The functional role of the DTL of the intermediate loop may be distinct from the short or long loops."
> "Q8VHL0-1","RefSeq","NP_082398.1","26407594","We conclude that transgenic expression of UT-A1 restores basal urea permeability to the level in wild-type mice but does not restore vasopressin-stimulated levels of urea permeability. This information suggests that transgenic expression of UT-A1 alone in mice lacking UT-A1 and UT-A3 is sufficient to restore urine-concentrating ability"
> "Q8VHL0-1","RefSeq","NP_082398.1","25298344","Studies indicate that urea transporter Slc14a1 UT-B is an indispensable transporter involved in maintaining physiological functions in different tissues. Review article"
> "Q8VHL0-1","RefSeq","NP_082398.1","12965892","UT-B-deficient mice reveal that countercurrent exchange of urea in renal medullary vessels and red blood cells accounts for a major part of the kidney's concentrating ability and for the adaptation of renal urea handling during a high-protein intake."
> "Q8VHL0-1","RefSeq","NP_082398.1","12952854","Potassium depletion is associated with reduced expression of UT-A1, UT-A3, and UT-B but increased expression of UT-A2"
> "Q8VHL0-1","RefSeq","NP_082398.1","12133842","UT-B has a role in urinary concentrating ability in mice"
5765,5767d7670
< "Q8VCQ6-1","RefSeq","NP_001161997.1","30243987","Knockdown of SMS1 promotes lysosomal degradation of BACE1 and attenuates Alzheimer's disease-like pathology in transgenic mice."
< "Q8VCQ6-1","RefSeq","NP_001161997.1","30305392","2-Hydroxy-oleic acid inhibited rather than activated recombinant SMS1 (rSMS1) and rSMS2 in a dose-dependent fashion. Erratum:[J Biol Chem. 2019 May 31;294(22):8716. PMID: 31152097]"
< "Q8VCQ6-1","RefSeq","NP_001161997.1","27892528","SMS1 contributed to sphingomyelin generation inducing Japanese encephalitis virus attachment and infection. Publication Status: Online-Only"
5776a7680
> "Q149B8-1","RefSeq","NP_766005.2","23836911","A role for Perm1 acting downstream of PGC-1alpha and ERRs to regulate muscle-specific pathways important for energy metabolism and contractile function."
5780a7685,7693
> "Q8K4S1-1","RefSeq","NP_062534.2","28209735","2-arachidonoylglycerol (2-AG) is an endogenous cannabinoid that depresses synaptic transmission through stimulation of CB1 receptors. Among the six isoforms of phospholipase C (PLC; PLCbeta, PLCgamma, PLCdelta, PLCepsilon, PLCzeta, PLCeta), only PLCbeta has been linked to 2-AG synthesis. Here we demonstrate that 8-CPT-2Me-cAMP, a selective agonist of the cAMP sensor protein Epac, enhances 2-AG-mediated synaptic depress..."
> "Q8K4S1-1","RefSeq","NP_062534.2","28093232","Study shed light on a novel role of PLCepsilon in wound healing and provided new therapeutic approaches to target PLCepsilon for diminishing scar formation after injury"
> "Q8K4S1-1","RefSeq","NP_062534.2","27449513","The first SNP rs29972765 is located in a gene desert on chromosome 18, about 72 kb upstream of Skor2 . The second SNP rs30415957 resides in the intron of Plce1.The remaining two SNPs (rs30768258 and rs31216810) are close to each other on chromosome 19, in the vicinity of Sorbs1.  Knockdown of Sorbs1 by siRNA attenuates the induction of differentiation marker gene Prl8a2 Publication Status: Online-Only"
> "Q8K4S1-1","RefSeq","NP_062534.2","12752375","The induction of phospholipase Cepsilon expression may be a specific event associated with the commitment of the neural precursor cells to the neuronal lineage."
> "Q9ER67-1","RefSeq","NP_109625.1","15162511","Maged2 is mainly expressed in tissues of mesodermal origin"
> "Q9ER67-1","RefSeq","NP_109625.1","11856887","Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues"
> "Q8C9J3-1","RefSeq","NP_796097.2","28619825","Investigated the function of SPEF2 during spermatogenesis using a male germ cell-specific Spef2 knockout model. In addition to defects in sperm tail development, we observed a duplication of the basal body and failure in manchette migration resulting in an abnormal head shape."
> "Q8C9J3-1","RefSeq","NP_796097.2","21715716","Data indicate that SPEF2 is required for cilia function/motility; defect in SPEF2 results in primary ciliary dyskinesia. SPEF2 plays important role in spermatogenesis and sperm flagellum assembly. (base/AA sequence data submitted to GenBank)"
> "Q8C9J3-1","RefSeq","NP_796097.2","19889948","The crucial importance of SPEF2 in sperm differentiation and involvement of SPEF2 in structuring of the sperm tail."
5784,5789d7696
< "Q6ZPF3-1","RefSeq","NP_001116470.1","30817801","Tiam2 is expressed in two isoforms, the full-length (Tiam2l) and a short transcript (Tiam2s). Tiam2s expression from the t-allele is strongly increased compared to the wild-type allele. By transgenic approaches we show that Tiam2s enhances t-haplotype transmission, while Tiam2l has the opposite effect. Publication Status: Online-Only"
< "O35714-1","RefSeq","NP_033426.1","30755607","Authors demonstrate that GITR engagement of activated, but not naive, ILC2s improves glucose homeostasis, resulting in both protection against insulin resistance onset and amelioration of established insulin- resistance. Publication Status: Online-Only"
< "O35714-1","RefSeq","NP_033426.1","29623077","A novel association of Group 1 innate lymphoid cell (ILC1) functionality and the expression of GITR was observed, which hints toward a so far undescribed role of GITR in regulating ILC1s responsiveness. Overexpression of GITR inhibits IFN-gamma production by ILC1s, whereas partial reduction of GITR expression can reverse this effect, thereby regulating ILC1 functionality. Publication Status: Online-Only"
< "O35714-1","RefSeq","NP_033426.1","28611044","Expression of human GITR was comparable with that of mouse GITR in tumor-infiltrating Tregs despite being drastically lower in other human TILs and in many human peripheral blood populations."
< "O35714-1","RefSeq","NP_033426.1","28649380","These findings support further study into combination partners for GITRL-FP that may augment CD8 T-cell priming as well as provide hypotheses that can be tested in human clinical trials exploring GITR agonists including GITRL-FP. Publication Status: Online-Only"
< "O35714-1","RefSeq","NP_033426.1","11869690","A functional role for this receptor in regulating the CD4+CD25+ T cell subset."
5795,5796c7702,7706
< "P97868-1","RefSeq","NP_035377.2","17470788","The PACT-p53 interaction plays a critical role in embryonic development and tumorigenesis and identify PACT as a member of negative regulators of p53."
< "P97868-1","RefSeq","NP_035377.2","15617101","P2P-R expression may be translationally regulated by PUM2 and that P2P-R may modulate translation by influencing ribosomal protein gene expression"
---
> "Q80UN1-1","RefSeq","NP_598834.2","29940856","Interference with potassium channel tetramerisation domain containing 9 (KCTD9) expression exert beneficial effect in viral fulminant hepatitis therapy, which may be mediated by impairment of NK cell activation. Publication Status: Online-Only"
> "Q80UN1-1","RefSeq","NP_598834.2","22433305","A novel potassium channel gene KCTD9 was highly expressed in hepatic NK cells and T cells of fulminant hepatitis mice induced by MHV-3."
> "Q91VZ6-1","RefSeq","NP_082810.1","26296315","Either SMAP1 or SMAP2, is required for proper embryogenesis"
> "Q91VZ6-1","RefSeq","NP_082810.1","23434593","Enhanced endocytosis of transferrin in Smap1-targeted mice might facilitate the active iron metabolism and c-KIT-induced growth of erythroblasts and myelodysplastic syndrome/acute myeloid leukemia cells."
> "Q61686-1","RefSeq","NP_031652.1","29795351","Results reveal that ADNP, via the recruitment of HP1 and CHD4, regulates the expression of genes that are crucial for maintaining distinct cellular states and assures accurate cell fate decisions upon external cues"
5801,5805d7710
< "Q8BTG7-1","RefSeq","NP_001181935.1","28524415","NDRG4 is exclusively expressed by central, peripheral and enteric neurons/nerves, suggesting a neuronal-specific role of this protein"
< "Q8BTG7-1","RefSeq","NP_001181935.1","27175791","NDRG4 might play an important role during early pregnancy. Publication Status: Online-Only"
< "Q8BTG7-1","RefSeq","NP_001181935.1","26780215","Up-regulation of NDRG4 aggravates myocardial ischemia/reperfusion injury by inhibiting activation of the RISK pathway"
< "Q8BTG7-1","RefSeq","NP_001181935.1","26801554","Availability of the conditional allele for Ndrg4 should facilitate further detailed analyses of the potential roles of Ndrg4 in gut development, nervous system and immune system."
< "Q8BTG7-1","RefSeq","NP_001181935.1","17998568","These expression patterns demonstrated the cell type-specific and ubiquitous localization of the NDRG family proteins. Each NDRG may play a partially redundant role in specific cells in the brain."
5809,5810c7714
< "Q8BHS8-1","RefSeq","NP_001272769.1","22975310","Syntabulin could be a novel effector of Epac2 and play a critical role in cAMP-enhanced insulin secretion"
< "Q8BHS8-1","RefSeq","NP_001272769.1","16750881","Results may indicate a significant role for this protein in neuronal cells and other types of cells such as those of the choroid plexus and ciliary body"
---
> "Q80X50-1","RefSeq","NP_082751.1","25185265","Two different BMI1-containing PcG complexes regulate hematopoietic stem cell activity, which are distinguishable by the presence of UBAP2L."
5818d7721
< "Q91VM3-1","RefSeq","NP_001277721.1","26000824","Nes-Wdr45(fl/Y) mice recapitulate some hallmarks of beta-propeller protein-associated neurodegeneration, including cognitive impairment and defective axonal homeostasis"
5823a7727
> "Q4VAA7-1","RefSeq","NP_780692.2","18419754","SNX33 interferes with cellular PrP formation by modulation of PrP shedding"
5828a7733,7738
> "Q9CWY8-1","RefSeq","NP_081463.1","26880576","The G37S mutation of RNaseH2 led to increased expression of interferon-stimulated genes dependent on the cGAS-STING signaling pathway."
> "Q9CWY8-1","RefSeq","NP_081463.1","23744109","Recent evidence gathered from ribonuclease H2 knock-out mice provides insight into the molecular mechanisms underlying Aicardi-Goutieres syndrome development and a potential role of DNA damage as a trigger of autoimmunity is discussed. [review] Review article"
> "Q9CWY8-1","RefSeq","NP_081463.1","21454563","Analysis of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome"
> "Q9CWY8-1","RefSeq","NP_081463.1","19923215","Data show that the interwoven architecture of RNase H2B and RNase H2C that interface with RNase H2A in a complex ideally suited for nucleic acid binding and hydrolysis coupled to protein-protein interaction motifs."
> "Q8BHS8-1","RefSeq","NP_848880.2","22975310","Syntabulin could be a novel effector of Epac2 and play a critical role in cAMP-enhanced insulin secretion"
> "Q8BHS8-1","RefSeq","NP_848880.2","16750881","Results may indicate a significant role for this protein in neuronal cells and other types of cells such as those of the choroid plexus and ciliary body"
5843a7754
> "Q9CRZ8-1","RefSeq","NP_081568.1","19729679","Identify the TSPO2 family of proteins as mediators of cholesterol redistribution-dependent erythroblast maturation during mammalian erythropoiesis"
5849a7761
> "Q8CBW4-1","RefSeq","NP_848854.3","17660561","Transcripts highly enriched in ovary; gene identified as candidate female fertility factor."
5851a7764,7766
> "Q91YU6-1","RefSeq","NP_663478.2","28323888","The data demonstrate the significance of simultaneous Pten and Lzts2 deletion in oncogenic transformation in prostate cells and implicates a new mechanism for the dysregulation of Wnt/beta-catenin signaling in prostate tumorigenesis. Publication Status: Online-Only"
> "Q91YU6-1","RefSeq","NP_663478.2","23275340","Deletion of Lzts2 increases susceptibility to spontaneous and carcinogen-induced tumor development."
> "Q91YU6-1","RefSeq","NP_663478.2","21949185","A critical role of LZTS2 in renal development and implicate LZTS2 as a critical regulator of beta-catenin-mediated nephrogenesis."
5855,5856c7770,7774
< "Q9DCG2-1","RefSeq","NP_001277589.1","27316686","These studies confirm a functional role for CD302 in myeloid dendritic cells migration."
< "Q9DCG2-1","RefSeq","NP_001277589.1","17947679","HDCL-1 is an unconventional lectin receptor that plays roles not only in endocytosis/phagocytosis but also in cell adhesion and migration"
---
> "Q8BGY7-1","RefSeq","NP_722489.1","29618611","Fam210a was expressed in muscle mitochondria and cytoplasm but not in bone. Nevertheless, in genetically modified mouse models, Fam210a strongly influenced the structure and strength of both muscle and bone."
> "Q61475-1","RefSeq","NP_034146.2","28838952","Regulates self-renewal and cisplatin resistance in endometrioid tumors"
> "Q61475-1","RefSeq","NP_034146.2","27929130","CD133-CD55- common progenitors are the main source of CXCL12 and Kitl producing cells in the developing marrow. Publication Status: Online-Only"
> "Q61475-1","RefSeq","NP_034146.2","27494303","These data show a key role for HIF-1alpha in regulating the expression of CD55 on airway epithelium."
> "P09240-1","RefSeq","NP_112438.1","30643290","Knockdown of CB1R in the CCK-D2 medium spiny neurons circuit elevated synaptic activity and promoted stress susceptibility. Erratum:[Nat Med. 2019 Jan 30;:. PMID: 30700866]"
5862a7781,7787
> "Q8CE08-1","RefSeq","NP_997551.1","27783536","These findings demonstrate that PAP secreted by PCa cells in OB bone metastases increases osteoprotegerin and plays a critical role in the vicious cross talk between cancer and bone cells."
> "Q8CE08-1","RefSeq","NP_997551.1","27348306","PAP-immunoreactivity was present in type I and one of type III taste cells of taste buds. Thus, it is suggested that PAP might be a responsible ectoenzyme for metabolism of extracellular nucleotides, being involved in the regulation of taste signaling in taste buds. Publication Status: Online-Only"
> "Q8CE08-1","RefSeq","NP_997551.1","27306411","Functional PAP(thorn) neurons are essential for the analgesic effect, which is mediated by NGF-trkA signaling. Publication Status: Online-Only"
> "Q8CE08-1","RefSeq","NP_997551.1","19158948","PAP has species-conserved antinociceptive effects and has pH-dependent ectonucleotidase activity"
> "Q99LE2-1","RefSeq","NP_084534.2","28464285","GPR146 has an antiviral role in fighting against viral infection, although the GPR146-mediated protection is eliminated by IRF3/HES1-signalling."
> "Q61554-1","RefSeq","NP_032019.2","30642872","This model captures key aspects of Marfan-related syndromes, providing insights into the role of fibrillin-1 in eye development and disease. Publication Status: Online-Only"
> "Q61554-1","RefSeq","NP_032019.2","30359839","Fbn1(C1039G/+) Marfan mouse with extreme aortic dilatation and increased vascular inflammation, which coincided with unilateral renal cystic disease."
5866a7792,7793
> "Q91VH6-1","RefSeq","NP_598532.1","26746790","Memo1 showed robust expression in the perichondrium and periosteum of the developing cranial base, but only modest expression in the palatal shelves. Neural crest cell-specific deletion of Memo1 caused a failure of anterior cranial base ossification indicating a cell autonomous role for MEMO1 in the development of these structures, but palatal formation was normal, indicating a non-autonomous role in palatal closure."
> "Q91VH6-1","RefSeq","NP_598532.1","17077023","Tissue distribution of Memo in mice."
5874a7802,7810
> "Q923B3-1","RefSeq","NP_075357.4","18677445","Data show that in vitro down regulation of NRIF expression decreased the mRNA for two main cholesterogenic enzymes, 3-hydroxy-3-methylglutaryl-coenzyme A reductase and 7-dehydrocholesterol reductase."
> "Q923B3-1","RefSeq","NP_075357.4","12935912","NRIF gene expression gradually decreassedas development progressed."
> "Q9EP97-1","RefSeq","NP_109627.3","29277914","In the present study demonstrate for the first time that SENP3 are ubiquitously distributed in the adult murine brain."
> "Q9EP97-1","RefSeq","NP_109627.3","29576508","We provide the first direct evidence that SENP3 upregulation pivotally contributes to myocardial ischemia reperfusion (MIR) injury in a Drp1-dependent manner, and suggest that SENP3 suppression may hold therapeutic promise for constraining MIR injury."
> "Q9EP97-1","RefSeq","NP_109627.3","29352108","High SENP3 potentiates lipopolysaccharide-induced inflammation via deSUMOylation of MKK7 leading to enhancement in JNK phosphorylation."
> "Q9EP97-1","RefSeq","NP_109627.3","25772139","The present study examined dynamic changes in SENP3 expression in the cerebral cortex and in its cellular localization."
> "Q9EP97-1","RefSeq","NP_109627.3","18948745","The p53-independent tumor suppressive functions of p19(Arf) may be mediated by its ability to antagonize Senp3, thereby inducing cell cycle arrest by abnormally elevating the cellular levels of SUMOylated proteins."
> "Q924T3-1","RefSeq","NP_082288.1","29077092","This damaging phenotype highlights the functional nexus between Xlf and Xrcc4, which is critical for the completion of NHEJ-dependent mechanisms during mouse development."
> "Q924T3-1","RefSeq","NP_082288.1","29233683","These data imply that the level of XRCC4 expression could be used to predict the effects of apoptosis-inducing drugs in cancer treatment."
5877a7814
> "Q9WTT4-1","RefSeq","NP_075668.1","12133826","V-ATPase G1 and G2 isoforms are expressed in mouse embryo neurons and are involved in synaptic vesicle acidification"
5881a7819,7825
> "Q80YR6-1","RefSeq","NP_001239424.1","29020620","CtIP enhances long-range resection by BLM-DNA2-RPA.  CtIP interacts with and stimulates the activity of the BLM helicase and upregulates DNA2 activity."
> "Q80YR6-1","RefSeq","NP_001239424.1","28065643","We reveal that reprogramming is associated with high levels of DNA end resection, a critical step in homologous recombination. Moreover, the resection factor CtIP is essential for cell reprogramming and establishment of iPSCs, probably to repair reprogramming-induced DNA damage."
> "Q80YR6-1","RefSeq","NP_001239424.1","27869555","Q418P nsSNP influences the efficiency of CTIP function in HR repair of DNA DSBs"
> "Q80YR6-1","RefSeq","NP_001239424.1","27117402","Ctip1 couples subtype and area specification, enabling specific functional areas to organize precise ratios of appropriate output projections."
> "Q80YR6-1","RefSeq","NP_001239424.1","16581787","CtiP activates its own and cyclin D promoters via the E2F/RB pathway during G1/S progression."
> "Q80YR6-1","RefSeq","NP_001239424.1","16093251","Rbbp8 is shown to be upregulated in response to X-irradiation in the AML sensitive CBA strain but not AML resistant C57BL/6 strain"
> "Q80YR6-1","RefSeq","NP_001239424.1","15831459","CtIP counteracts Rb-mediated G(1) restraint."
5885a7830,7833
> "O08785-1","RefSeq","NP_031741.1","30530698","HNF4A strongly transrepresses the transcriptional activity of the CLOCK:BMAL1 heterodimer."
> "O08785-1","RefSeq","NP_031741.1","30413606","The predicted CLOCK regulated miRNAs at two time points participated in extremely diverse pathways. The study validated nine miRNAs (miR-125a-3p, miR-144, miR-199a-5p, miR-199b*, miR-200a, miR-200b, miR-203, miR-449a, and miR-96), which were involved in the same signaling pathway-hippo signaling pathway. Publication Status: Online-Only"
> "O08785-1","RefSeq","NP_031741.1","30124738","Results indicate that circadian locomotor output cycles kaput protein (CLOCK) overexpression triggers the formation of atherosclerotic plaques by directly upregulating plasminogen activator inhibitor 1 (PAI-1) expression."
> "O08785-1","RefSeq","NP_031741.1","30695595","Carcinogenic exposure decreased BMAL1 and CRYI- expression in the skin, CLOCK expression was upregulated and CRYl downregulated in tumor compared to normal skin. BMAL1 expression increased under disrupted light regimen; melatonin treatment affected CLOCK expression in tumors and CRYI in skin at the carcinogens application sites."
5903a7852,7856
> "Q9JMI0-1","RefSeq","NP_067281.2","29132416","This study demonstrated that the ECEL1/DINE G607S and C760R mutations both lead to motor innervation defects as primary causes in ECEL1-mutated congenital contracture disorders. Publication Status: Online-Only"
> "Q9JMI0-1","RefSeq","NP_067281.2","28569783","DINE enhances axonal regeneration potential of retinal ganglion cells after optic nerve injury. Publication Status: Online-Only"
> "Q9JMI0-1","RefSeq","NP_067281.2","27656015","DINE is expressed in cranial and spinal motor neurons both embryonically and after CNS injury"
> "Q9JMI0-1","RefSeq","NP_067281.2","20484637","The data of this study suggested that DINE is a crucial molecule in distal axonal arborization into muscle to establish neuromuscular junctions."
> "Q9JMI0-1","RefSeq","NP_067281.2","18192274","Sp1 recruits ATF3, c-Jun, and STAT3 to obtain the requisite synergistic effect in neuronal injury through DINE neuronal injury-inducible gene"
5910,5911d7862
< "Q61473-1","RefSeq","NP_001276393.1","31073164","Study in a mouse endotoxemia model of inflammatory endothelial injury and human cells demonstrated that endothelial Sox17 expression plays an obligatory role in normalizing the endothelium. Restoration of endothelial integrity is mediated by activation of HIF-1alpha, upregulation of its target Sox17, and subsequent downstream expression of Cyclin E1 which mediates endothelial regeneration. Publication Status: Online-Only"
< "Q61473-1","RefSeq","NP_001276393.1","11973269","Important role of Sox17 in endoderm development in the mouse"
5919a7871,7880
> "Q9D8Y7-1","RefSeq","NP_081482.1","29654762","TIPE2 enhances the cytoskeleton remodeling and promotes the thymus egress of Regulatory T cells."
> "Q9D8Y7-1","RefSeq","NP_081482.1","29480366","Our study identifies the molecular mechanisms underlying the interplay of TNF-alpha, TIPE2, and apoptosis during allograft rejection, and it suggests that both TNF-alpha and TIPE2 might be potential targets for the successfully grafted corneal endothelium."
> "Q9D8Y7-1","RefSeq","NP_081482.1","29196266","TIPE-2 held a protective effect on liver fibrosis and could be a potential therapeutic target."
> "Q9D8Y7-1","RefSeq","NP_081482.1","29115630","TIPE2 serves an important role in orchestrating the differential polarization status of macrophages, via negative regulation of mTORC1 activation and accelerated conversion of arginine to urea."
> "Q9D8Y7-1","RefSeq","NP_081482.1","29058702","The results reported here indicated a crucial role for TIPE2 in the infiltration of leukocytes into neural tissue in Experimental Autoimmune Encephalomyelitis."
> "Q9D8Y7-1","RefSeq","NP_081482.1","22859306","TIPE2 plays an essential role in a signal transduction pathway that links the inflammatory immune response to specific conditions after cerebral ischemia."
> "Q9D8Y7-1","RefSeq","NP_081482.1","21963221","The results suggested that TIPE2 appeared to be a critical immunoregulatory molecule involved in immunosuppressive function of CD4(+)CD25(+) Tregs."
> "Q9D8Y7-1","RefSeq","NP_081482.1","21466895","These results indicate that TIPE2 plays an important role in taming Hepatitis B virus-induced hepatic inflammation."
> "Q9D8Y7-1","RefSeq","NP_081482.1","20663561","TIPE2 expression was detected in various murine tissues by immunohistochemistry & RT-PCR. TIPE2 was a cytoplasmic protein expressed preferentially in lymphoid tissues and a small group of non-lymphoid tissues."
> "Q9D8Y7-1","RefSeq","NP_081482.1","18455983","This paper establishes that TIPE2 is an essential negative regulator of TLR and TCR function, and its selective expression in the immune system prevents hyperresponsiveness and maintains immune homeostasis."
5926c7887,7888
< "Q8BX57-1","RefSeq","NP_663433.2","16135750","MONaKA modulates brain Na,K-ATPase by binding tightly to its beta1 and beta3 subunits, and may thereby participate in the regulation of electrical excitability and synaptic transmission."
---
> "Q9D6Z0-1","RefSeq","NP_081648.1","28726787","Results uncover an in vivo role for ALKBH7 in mediating a sexually dimorphic tissue response to alkylation damage that could influence individual responses to chemotherapies based upon alkylating agents. Publication Status: Online-Only"
> "Q9D6Z0-1","RefSeq","NP_081648.1","23572141","The first direct demonstration that murine Alkbh7 is a mitochondrial resident protein involved in fatty acid metabolism and the development of obesity."
5947a7910
> "P56380-1","RefSeq","NP_079815.2","21402779","Ap4A hydrolase was found to translocate into the nuclei of mast cells following immunological activation; found its immunologically dependent association with importin beta"
5951a7915,7917
> "P35276-1","RefSeq","NP_114080.2","27076615","Loss of Rab3D from secretory vesicles, leading to disproportionate Rab27-to-Rab3D activity, may contribute to the enhanced release of cathepsin S in tears of patients with Sjogren's syndrome."
> "P35276-1","RefSeq","NP_114080.2","26227614","Data suggest that both microtubule-associated DYNLT (dynein light chain Tctex-type 1) and cytoplasmic DYNLT (dynein 1 intermediate chain 2 DYNC1LI2) are equally able to bind to small GTPases Rab3D (Rab3d GTPase) and RagA (Ras-related GTP binding A)."
> "P35276-1","RefSeq","NP_114080.2","23050002","Acute expression of Rab1 and Rab3d DN constructs partially alleviated this negative feedback mechanism and resulted in impaired ER to Golgi trafficking of procollagen."
5954a7921,7922
> "Q61288-1","RefSeq","NP_033742.2","30165893","Our data show that in a tumor environment BMP9 and BMP10 play different roles and thus blocking their shared receptor ALK1 is maybe not appropriate. Indeed, BMP9, but not BMP10, acts as a quiescence factor on tumor growth, lung metastasis and vessel normalization. Publication Status: Online-Only"
> "Q61288-1","RefSeq","NP_033742.2","29449337","Loss of ALK1 function in endothelial cells results in increased activity of the PI3K pathway and vascular hyperplasia."
5961,5967d7928
< "Q8K1E3-1","RefSeq","NP_001272942.1","30888503","The expression pattern of DLK2 indicates that both proteins could play a synergistic role during cell differentiation. Erratum:[Histochem Cell Biol. 2019 May 16;:. PMID: 31093774]"
< "Q8K1E3-1","RefSeq","NP_001272942.1","29057471","The expression of the Dlk2 protein in the limb bud could be detected at embryonic day 11.5."
< "Q8K1E3-1","RefSeq","NP_001272942.1","28863347","Deletion of Dlk2 increased anxiety and depressive-like behaviors and altered the vulnerability to restraint stress."
< "Q8K1E3-1","RefSeq","NP_001272942.1","22306741","KLF4 mediates the transcriptional regulation of Dlk2 in response to IBMX during the early stages of adipogenesis"
< "Q8K1E3-1","RefSeq","NP_001272942.1","22185379","Our results provide the first characterization of Dlk2 transcripts, map the location of the Dlk2 core promoter, and show the role of Sp1 as a key regulator of Dlk2 transcription Publication Status: Online-Only"
< "Q8K1E3-1","RefSeq","NP_001272942.1","21419176","Data show that DLK1 and DLK2 act as inhibitory non-canonical protein ligands for the NOTCH1 receptor that modulate NOTCH signaling."
< "Q8K1E3-1","RefSeq","NP_001272942.1","17320102","Adipogenesis may be modulated by the coordinated expression of Dlk1 and EGFL9/Dlk2."
5974a7936,7938
> "Q8VCZ7-1","RefSeq","NP_663331.1","30959128","Zbtb7c to be a crucial metabolic regulator of blood glucose homeostasis, during mammalian fasting."
> "Q8VCZ7-1","RefSeq","NP_663331.1","27646874","Findings show that Zbtb7c is a key molecule that recruits an NCoR/Hdac3 complex to inhibit phosphorylation of c-Jun, and thereby repress Mmp gene expression"
> "Q8VCZ7-1","RefSeq","NP_663331.1","22331133","Kr-pok (kidney cancer-related POZ domain and Kruppel-like protein) activates transcription of the FASN gene."
5980a7945,7949
> "O88495-1","RefSeq","NP_034470.1","29572483","GPR50 is a TbetaRI co-receptor with potential impact on cancer development Publication Status: Online-Only"
> "O88495-1","RefSeq","NP_034470.1","25689717","GPR50 promotes neuronal differentiation through its intracellular domain."
> "O88495-1","RefSeq","NP_034470.1","23584857","Data indicate that Txnip expression is increased in the hypothalamus of Gpr50-/- mice during torpor."
> "O88495-1","RefSeq","NP_034470.1","20210849","Antibodies were used to study the expression of GPR50 in mouse, rat and human hypothalamus.GPR50 immunoreactivity (ir) was observed in dorsomedial hypothalamic (DMH) cells and in cells of the ependymal layer of the third ventricle of the hypothalamus."
> "O88495-1","RefSeq","NP_034470.1","17957037","GPR50 is an important regulator of energy metabolism"
5982a7952
> "P70445-1","RefSeq","NP_034254.1","29712774","Genetic deletion of 4E-BP1/2 in macrophages increased endogenous IL-10."
5995a7966,7971
> "Q9Z0J7-1","RefSeq","NP_035949.2","30554141","Circulating GDF-15 is a biomarker of muscle loss in pulmonary arterial hypertension that is responsive to treatment."
> "Q9Z0J7-1","RefSeq","NP_035949.2","29750874","GDF15 plays a role in hematopoiesis"
> "Q9Z0J7-1","RefSeq","NP_035949.2","29717162","GDF15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice. Publication Status: Online-Only"
> "Q9Z0J7-1","RefSeq","NP_035949.2","15897808","GDF-15/MIC-1 is an early mediator of the injury response in kidney and lung"
> "Q9Z0J7-1","RefSeq","NP_035949.2","12514175","GDF-15 prevents apoptosis in cerebellar granule neurons by activating Akt and inhibiting endogenously active ERK"
> "Q8CBA2-1","RefSeq","NP_899024.3","24089532","Several mouse Slfn genes are up-regulated in response to IFN treatment of mouse melanoma and renal cell carcinoma cells, including Slfn1, Slfn2, Slfn4, Slfn5, and Slfn8."
6002a7979,7980
> "O08705-1","RefSeq","NP_001171032.1","28498614","NTCP and OATP isoforms cooperatively form a stable bile acid uptake machinery in mice, whereas NTCP is predominant in humans."
> "O08705-1","RefSeq","NP_001171032.1","26306036","Ntcp plasma membrane localization is regulated by hyperosmolarity and tauroursodeoxycholate Erratum:[J Biol Chem. 2016 Jul 22;291(30):15908. PMID: 27451430]"
6009a7988,7990
> "Q8VDC1-1","RefSeq","NP_683727.3","28291748","The crystal structure of mouse LC3B in complex with the FYCO1 LC3-interacting region (LIR) reveals the importance of the flanking region of the LIR motif."
> "Q8VDC1-1","RefSeq","NP_683727.3","27929729","Ribonucleoprotein granule homeostasis is regulated by FYCO1-mediated autophagy."
> "Q8VDC1-1","RefSeq","NP_683727.3","24442442","FYVE and coiled-coil domain containing 1 (FYCO1), a protein previously implicated in autophagosome trafficking, is recruited directly by LC3 to Dectin-1 phagosomes."
6013a7995
> "Q69ZQ1-1","RefSeq","NP_001078984.1","29910000","In mice, Myorg mRNA was expressed specifically in S100beta-positive astrocytes, and knockout of Myorg induced the formation of brain calcification at 9 months of age."
6015a7998,8003
> "Q8CGW9-1","RefSeq","NP_082008.1","22972322","Dmrt7 is critical for the normal pachytene spermatogenesis and complete meiotic recombination."
> "Q8CGW9-1","RefSeq","NP_082008.1","21060727","Data suggests that NF-Y can activate the Dmrt7 promoter by binding to the tandem CCAAT boxes . Publication Status: Online-Only"
> "Q8CGW9-1","RefSeq","NP_082008.1","17447844","DMRT7 may help control the transition from meiotic sex chromosome inactivation to postmeiotic sex chromatin in males."
> "Q8CGW9-1","RefSeq","NP_082008.1","17098235","Decreased expression of Ccna1 mRNA and the accumulation of SCP3-positive spermatocytes showed the arrest of spermatogenesis at the pachytene stage in the Dmrt7-knockout mice."
> "Q9CZQ6-1","RefSeq","NP_937836.1","27444966","Study reports that retinoic acid early induced transcript-1-d and retinoic acid early induced transcript-1-e (Raet1) genes are induced early upon experimental autoimmune encephalomyelitis onset and reach a maximal expression at the peak of the pathology. Study also shows that macrophages as well as microglia, are cellular sources of Raet1 transcripts."
> "Q9CZQ6-1","RefSeq","NP_937836.1","24708417","CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1epsilon transgenic mice."
6017a8006,8015
> "Q8BLM0-1","RefSeq","NP_776141.1","26071188","Klf8 is highly expressed in various regions of the mouse brain and in particular in the neurons, where it was localized in the cell nuclei."
> "Q8BLM0-1","RefSeq","NP_776141.1","23716600","KLF3 and KLF8 have overlapping roles in vivo and participate in the silencing of embryonic globin expression during development."
> "Q8BLM0-1","RefSeq","NP_776141.1","23285057","KLF8 is a key component of the transcription factor network that controls terminal differentiation during adipogenesis."
> "Q8BLM0-1","RefSeq","NP_776141.1","21518760","PARP-1 as a novel KLF8-binding and -regulating protein and provided new insights into the mechanisms underlying the regulation of KLF8 nuclear localization, stability, and functions."
> "P70428-1","RefSeq","NP_034293.2","27650265","Let-7b-mediated suppression of initiation codon depends on the length of 5'-UTR of EXT2 mRNA and its suppression is inhibited in the presence of polyamines. Publication Status: Online-Only"
> "P70428-1","RefSeq","NP_034293.2","25468659","Heterozygous loss of function of EXT1 and EXT2 results in a decreased arteriolar endothelial glycocalyx but improved flow mediated vasodilation. Publication Status: Online-Only"
> "Q5BL07-1","RefSeq","NP_082053.1","15328346","Functions as a protein unfoldase in peroxisomal biogenesis, using its N-terminal putative adaptor-binding domain"
> "Q5BL07-1","RefSeq","NP_082053.1","15502339","Crystal structure of pex1"
> "Q99NB3-1","RefSeq","NP_083743.2","25020229","A conserved noncoding sequence (CNS1) located upstream of TCAM1 is a novel enhancer for Tcam1 gene expression. Erratum:[J Mol Biol. 2015 May 22;427(10):1993-4]"
> "Q99NB3-1","RefSeq","NP_083743.2","19766163","Data show that TCAM1 is not essential for male fertility or germ cell function in Mus musculus."
6024a8023
> "Q02105-1","RefSeq","NP_031600.2","21862594","Analysis of the molecular mechanisms for synchronized transcription of three complement C1q subunit genes (A, B and C) in dendritic cells and macrophages"
6026,6034d8024
< "Q5SWZ9-1","RefSeq","NP_001277212.1","29113556","PLD6 is a surface marker of undifferentiated spermatogonia in testes."
< "Q5SWZ9-1","RefSeq","NP_001277212.1","28749988","The Dnmt3l mutation greatly reduced DNA methylation levels at most retrotransposons, but its impact on their RNA abundance was limited in prospermatogonia. In Pld6 mutant germ cells, although only a few retrotransposons exhibited reduced DNA methylation, many showed increased expression at the RNA level. Publication Status: Online-Only"
< "Q5SWZ9-1","RefSeq","NP_001277212.1","28115634","MIWI (or PIWIL1) depletion had a smaller effect. In oocytes lacking PLD6 (or ZUCCHINI or MITOPLD), a mitochondrial nuclease/phospholipase involved in piRNA biogenesis in male germ cells, the piRNA level was decreased to 50% compared to wild-type."
< "Q5SWZ9-1","RefSeq","NP_001277212.1","27635761","Drp1 binds a mitochondrial enzyme that produces phosphatidic acid, MitoPLD, and regulates mitochondrial division."
< "Q5SWZ9-1","RefSeq","NP_001277212.1","26711011","Propose that MIGA proteins promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD."
< "Q5SWZ9-1","RefSeq","NP_001277212.1","23064227","Crystal structure of mZuc at 1.75 A resolution indicates greater architectural similarity to phospholipase-D family nucleases than to phospholipases; data suggest that the Zucchini proteins act in primary piRNA biogenesis as nucleases, perhaps generating the 5' ends of primary piRNAs."
< "Q5SWZ9-1","RefSeq","NP_001277212.1","22281006","MitoPLD performs a critical function in a pathway that creates a specialized form of RNAi required by developing spermatocytes to suppress transposon mobilization during meiosis. Review article"
< "Q5SWZ9-1","RefSeq","NP_001277212.1","21397848","Data suggest that mitochondrial-surface phosphatidic acid generated by MitoPLD/Zuc recruits or activates nuage components critical for piRNA production."
< "Q5SWZ9-1","RefSeq","NP_001277212.1","21397847","Results indicate a conserved role for MITOPLD/Zuc in the piRNA pathway and link mitochondrial membrane metabolism/signaling to small RNA biogenesis."
6042a8033,8038
> "P34928-1","RefSeq","NP_031495.1","27976371","APOC1 expression induces glomerulosclerosis, potentially by increasing the cytokine response in macrophages."
> "P34928-1","RefSeq","NP_031495.1","22404376","Apolipoprotein C-I was significantly increased in obese mice plasma."
> "P34928-1","RefSeq","NP_031495.1","21157034","The absence of ApoC-I results in impaired memory functions, which is, together with previous data, suggestive of an important, bell-shaped gene-dose dependent role for ApoC-I in appropriate brain functioning"
> "P34928-1","RefSeq","NP_031495.1","17339654","Data suggest that apoC-I binds free fatty acids (FFA), thereby reducing the blood FFA for uptake by cells, and this mechanism can serve as an additional mechanism for the resistance to obesity and the cutaneous abnormalities of APOC1(+/+) mice."
> "P34928-1","RefSeq","NP_031495.1","12070157","Present observations provide direct support for a potent specific inhibition of CETP by plasma apoCI in vivo"
> "Q3URQ7-1","RefSeq","NP_766349.1","26525917","Identifies DDX58 and MTHFSD as two TDP-43 targets that are misregulated in amyotrophic lateral sclerosis. 1"
6050a8047,8054
> "Q8K458-1","RefSeq","NP_659193.3","29643149","Infiltrating neutrophils and 4T1 cells abundantly expressed prokineticin-2 (Prok2) and its receptor, Prokr1, respectively. Finally, the administration of 5-FU after the resection of the primary tumor failed to augment lung metastasis in the mice receiving Prokr1-deleted 4T1 cells."
> "Q8K458-1","RefSeq","NP_659193.3","28616754","The sexually dimorphic pattern of Prokr2 expression indicates differential roles in reproductive function and, potentially, in other physiological systems."
> "Q8K458-1","RefSeq","NP_659193.3","27184500","This study presents the first experimental evidence indicating a molecular interaction between anosmin 1 and PKR2. A truncated anosmin 1 protein comprising the first three domains of the protein interacts with the second extracellular loop of PKR2, involved in PK2 binding."
> "Q2MKA5-1","RefSeq","NP_789814.2","29573323","Data suggest that the Chrna5 D398N variant influences the effect of developmental nicotine exposure on nicotine intake of exposed offspring. This gene-environment interaction on striatal DA release may provide motivation for increased nicotine seeking in N Nic offspring and reduced consumption in D Nic offspring."
> "Q2MKA5-1","RefSeq","NP_789814.2","29954848","Deletion of the alpha5 subunit in mice markedly reduces the cellular response to nicotine and acetylcholine in the interpeduncular nucleus. Stimulation of alpha5-expressing IP neurons using optogenetics is aversive, but this effect requires priming by recent prior stimulation or exposure to nicotine. The smoking-associated variant of the alpha5 gene may increase the drive to smoke via loss of IP-mediated nicotine avers..."
> "Q2MKA5-1","RefSeq","NP_789814.2","29940207","Observations in hemiparkinsonian mice suggest that the lack of alpha5* nicotinic receptors results in attenuated dopaminergic neurodegeneration and motor dysfunction in a 6-OHDA neurotoxin model of Parkinson's disease; suggests potential for alpha5 subunit-containing nicotinic receptors as a novel target in the treatment of Parkinson's disease."
> "Q2MKA5-1","RefSeq","NP_789814.2","29158387","The findings reveal a proaddiction adaptive response to chronic nicotine in which nitric oxide and SST are released by a specific CHRNA5-expressing neuronal population to provide retrograde inhibition of the habenula- interpeduncular nucleus circuit and thereby enhance the motivational properties of nicotine."
> "Q2MKA5-1","RefSeq","NP_789814.2","28498560","Genetic deletion of alpha5 nAChR subunits leads to a behavioural phenotype that exactly matches that observed after antagonizing dopamine receptors."
6055a8060,8063
> "Q9JI83-1","RefSeq","NP_062411.1","29723063","Upon meiosis onset, active furin/IGF-1 receptor relocates into the cytoplasm to activate (phosphorylate) Akt to promote meiosis. In summary, our finding suggests that Plac1, a protein that is crucial for placentation, is also essential for oocyte meiosis and fertilization."
> "Q9JI83-1","RefSeq","NP_062411.1","29632317","Results provide evidence that Plac1 modulates a tolerogenic tumor microenvironment in part by modulating the chemokine axis in mammary tumors. Publication Status: Online-Only"
> "Q9JI83-1","RefSeq","NP_062411.1","29055961","Plac1 is abundantly expressed at the fetomaternal interface and in all trophoblast subtypes except in primary trophoblast giant cells. Plac1 knockdown retarded the progress of TS differentiation, indicating that Plac1 is necessary for normal trophoblast differentiation into various trophoblast subpopulations."
> "Q9JI83-1","RefSeq","NP_062411.1","26586843","Our findings suggest that Plac1 is involved in trophoblast cell proliferation, differentiation, and migration"
6061,6066d8068
< "Q9ET39-1","RefSeq","NP_001334115.1","29305520","Authors found that seSLAMF6 reduced activation-induced cell death and had an antiapoptotic effect on tumor-infiltrating lymphocytes."
< "Q9ET39-1","RefSeq","NP_001334115.1","28904129","Naive T cells regulate B cell survival in a SLAMF6-dependent manner"
< "Q9ET39-1","RefSeq","NP_001334115.1","28373584","In addition to its established role in Invariant NKT(iNKT) cell ontogeny, Ly108 regulates iNKT cell function in mice and humans"
< "Q9ET39-1","RefSeq","NP_001334115.1","27223891","CRISPR-Mediated Slamf1Delta/Delta Slamf5Delta/Delta Slamf6Delta/Delta Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects. Publication Status: Online-Only"
< "Q9ET39-1","RefSeq","NP_001334115.1","26878112","In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'."
< "Q9ET39-1","RefSeq","NP_001334115.1","15879084","Following targeted disruption of the LY108 gene, CD4+ T cell and innate responses are defective; a surprising role for Ly108 is revealed in the control of responses to bacteria by neutrophils, while macrophage functions are intact."
6077a8080,8086
> "Q3UHC7-1","RefSeq","NP_001277570.1","27476001","PROX1 overexpression in DAB2IP-deficient prostate cancer cells could enhance the accumulation of HIF1alpha protein by inhibiting ubiquitin pathway and then consequently induce an epithelial-mesenchymal transition response."
> "Q3UHC7-1","RefSeq","NP_001277570.1","26512963","DAB2IP loss reprograms intracellular signal transduction and anti-apoptotic gene expression, which potentiates prostate cancer cell survival from androgen deprivation therapy-induced cell death. Publication Status: Online-Only"
> "Q3UHC7-1","RefSeq","NP_001277570.1","26139244","Our data reveal that AIP1, by inhibiting VEGFR2-dependent signaling in tumor niche, suppresses tumor EMT switch, tumor angiogenesis, and tumor premetastatic niche formation to limit tumor growth and metastasis."
> "Q3UHC7-1","RefSeq","NP_001277570.1","26181199","Germ cell-specific or Sertoli cell-specific deletion of Aip1 gene each led to significant defects in germ cell migration after postnatal day 4 or 5, accompanied by elevated levels of actin filaments (F-actin) in the affected cells. Publication Status: Online-Only"
> "Q3UHC7-1","RefSeq","NP_001277570.1","25995115","Cor1B, Cof1 and AIP1 work in concert through a temporally ordered pathway to induce highly efficient severing and disassembly of actin filaments. Publication Status: Online-Only"
> "Q3UHC7-1","RefSeq","NP_001277570.1","18281285","AIP1 is essential for transducing the IRE1-mediated endoplasmic reticulum stress response."
> "Q3UHC7-1","RefSeq","NP_001277570.1","12877983","This study suggests that Dab2IP may function as a downstream effector in the Reelin signaling pathway that influences Ras signaling during brain development."
6084a8094
> "Q3US17-1","RefSeq","NP_666313.1","26423361","Novel insights to a newly identified pluripotency factor Zfp553 and its role in pluripotency regulation."
6085a8096,8101
> "Q61586-1","RefSeq","NP_032175.2","30523156","Preserved insulin receptor activity was supported by Thr-308 phosphorylation of Akt following GPAT1 overexpression in Them2 -/- hepatocytes."
> "Q61586-1","RefSeq","NP_032175.2","27010859","Silencing of GPAT1 by gpat1 siRNA transfection reduced glucosamine-mediated anti-apoptosis in mouse embryonic stem cells and reduced mammalian target of rapamycin phosphorylation. Publication Status: Online-Only"
> "Q2TBE6-1","RefSeq","NP_663476.1","23146885","Itch directly associates with and ubiquitinates PI4KIIalpha, and both proteins colocalize on endosomes containing Wnt-activated frizzled 4 (Fz4) receptor"
> "Q2TBE6-1","RefSeq","NP_663476.1","16772528","The unique N terminus of PI4K type IIalpha is required for the targeting of the enzyme to cellugyrin-positive vesicles."
> "Q2TBE6-1","RefSeq","NP_663476.1","15944223","PI4KIIalpha is present on adaptor protein (AP) -3 organelles where it regulates AP-3 function"
> "P59268-1","RefSeq","NP_766053.1","29944857","This study highlights a key role for zDHHC9 in brain development and behaviour"
6088,6095c8104,8111
< "Q9Z2G6-1","RefSeq","NP_001034178.1","30389665","This study not only establishes the importance of Sel1L-Hrd1 ERAD in the liver in the regulation of systemic energy metabolism, but also reveals a novel hepatic 'ERAD-Crebh-Fgf21' axis directly linking ER protein turnover to gene transcription and systemic metabolic regulation."
< "Q9Z2G6-1","RefSeq","NP_001034178.1","28920918","Mice deficient for ERAD machinery component Sel1L develop central diabetes insipidus"
< "Q9Z2G6-1","RefSeq","NP_001034178.1","20170518","Data suggest that Sel1l is essential for the growth and differentiation of endoderm-derived pancreatic epithelial cells during mouse embryonic development. Publication Status: Online-Only"
< "Q811P8-1","RefSeq","NP_001182561.1","30045817","Our results suggest that PX-RICS-mediated GABAAR trafficking is a key target for GABAergic plasticity and its dysfunction leads to atypical emotional processing underlying autism."
< "Q811P8-1","RefSeq","NP_001182561.1","17663722","These results suggest that PX-RICS is involved in early brain development including extension of axons and dendrites, and postnatal remodeling and fine-tuning of neural circuits."
< "Q811P8-1","RefSeq","NP_001182561.1","17272280","P200 RhoGAP can mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation"
< "Q811P8-1","RefSeq","NP_001182561.1","16716191","RICS plays an important role in neurite extension"
< "Q811P8-1","RefSeq","NP_001182561.1","12531901","RICS may regulate dendritic spine morphology and strength by modulating Rho GTPases [RICS]"
---
> "Q5I1X5-1","RefSeq","NP_001010836.1","29352264","The identification of a cell autonomous role of iASPP deficiency in causing cardiocutaneous syndrome, impaired eyelid development and wound healing suggests that variants in the iASPP gene also may contribute to polygenic heart and skin diseases."
> "Q5I1X5-1","RefSeq","NP_001010836.1","27242323","MiR-182 plays an aggressive role in the cerebral ischemia injury, and this is associated with inhibited iASPP expression."
> "Q5I1X5-1","RefSeq","NP_001010836.1","25691752","These data demonstrate that by interacting with desmoplakin and desmin, iASPP is an important regulator of desmosomal function both in vitro and in vivo."
> "Q5I1X5-1","RefSeq","NP_001010836.1","19263435","Studies revealed that overexpression of PPP1R13L causes faster p53 degradation, a likely explanation for the depletion of p53."
> "Q5I1X5-1","RefSeq","NP_001010836.1","15661756","Mice with mutation in Nkip1 (Ppp1r13l) represent a potentially important model for the analysis of the role of inflammatory processes in heart disease."
> "P70257-3","RefSeq","NP_035036.1","30511336","Mice lacking Nfix exhibit reduced numbers of granule cell precursors during early postnatal development, but elevated numbers of these cells at postnatal day 15. Moreover, Nfix(-/-) GNPs exhibit increased proliferation when cultured in vitro, suggestive of a role for NFIX in promoting GNP differentiation."
> "P70257-3","RefSeq","NP_035036.1","30503862","By modelling brain structure and behavior in Nfix heterozygous mice, the study provides a significant conceptual advance in our understanding of the factors underlying Malan syndrome."
> "P70257-3","RefSeq","NP_035036.1","30266829","Nfix is regulated through the RhoA/ROCK axis, which maintains embryonic myogenesis. Publication Status: Online-Only"
6110d8125
< "Q9JLL3-1","RefSeq","NP_001157627.1","29237753","Data show that Troy marks a renal stem/progenitor cell population in the developing kidney that in adult kidney contributes to homeostasis, predominantly of the collecting duct, and regeneration."
6118a8134
> "Q3UWW6-1","RefSeq","NP_001271273.1","28698371","Cardiomyocytes from Gas2l3-deficient mice exhibit increased expression of a p53-transcriptional program including the cell cycle inhibitor p21. Furthermore, loss of GAS2L3 results in premature binucleation of cardiomyocytes accompanied by unresolved midbody structures."
6119a8136
> "O55186-1","RefSeq","NP_031678.1","27729184","Data (including data from studies using knockout mice) suggest that CD59a, CD59b, and ApoE are involved in development of diabetes-induced atherosclerosis; here, deficiency of CD59a/CD59b (in ApoE deficient mice) accelerates development of atherosclerosis in mice with type 1 diabetes. (CD59a = CD59a antigen; CD59b = CD59b antigen; ApoE = apolipoprotein E)"
6123a8141,8142
> "Q8BGC0-1","RefSeq","NP_083647.1","24352707","Our results predict sex as a determinant of HIV effects in brain. Increased behavioral deficits in males correlated with glial activation and synaptic damage, both of which are implicated in cognitive/motor impairments in patients."
> "Q8BGC0-1","RefSeq","NP_083647.1","15485897","CA150 FF domains recognize multiple sites within the Tat-SF1 protein conforming to the consensus motif (D/E)(2/5)-F/W/Y-(D/E)(2/5)."
6124a8144,8146
> "Q6PAM1-1","RefSeq","NP_001186624.1","26494466","The TXLNA may serve as an important feedback mechanism to modulate the magnitude of subsequent phagocytotic process of SCs in response to testicular injury."
> "Q6PAM1-1","RefSeq","NP_001186624.1","19663695","Analysis of a novel monoclonal antibody against interleukin-14alpha"
> "Q6PAM1-1","RefSeq","NP_001186624.1","19038581","Transgenic mice in which IL-14a expression was increased constitutively develop all the clinical and immunological features of primary Sjogren's disease in the same relative time frame as patients with primary Sjogren's disease"
6138a8161
> "A3KGV1-1","RefSeq","NP_038643.1","29168316","Data show that the percentage of outer dense fiber of sperm tails 2 protein (ODF2) defects was higher in asthenozoospermic samples than that in control samples and was significantly correlated with the percentage of axoneme defects and non-motile sperm."
6147a8171,8175
> "Q3U2S8-1","RefSeq","NP_083028.1","30281323","This work therefore demonstrates that fully differentiated mammalian muscle fibers do not express functional voltage-gated H(+) channels and consequently can no longer be considered as the only vertebrate excitable cells exhibiting voltage-gated H(+) currents."
> "Q3U2S8-1","RefSeq","NP_083028.1","29550486","Loss of Hv1 significantly attenuates STZ-induced beta-cell damage and ROS production in pancreatic beta-cells; results suggest that Hv1 might contribute to development of diabetes through producing ROS."
> "Q3U2S8-1","RefSeq","NP_083028.1","28961043","The increase in ROS production in VSOP/Hv1-deficient cells was not observed in macrophages, which suggests microglia have a unique mechanism of VSOP/Hv1-dependent ROS regulation."
> "Q3U2S8-1","RefSeq","NP_083028.1","27470181","Microglial Hv1 proton channel is a unique target for modulation of microglial M1/M2 polarization in the pathogenesis of ischemic stroke"
> "Q3U2S8-1","RefSeq","NP_083028.1","16556803","Reported that VSOP, a four-transmembrane protein similar to the voltage-sensor domain of voltage-gated ion channels is a voltage-gated proton channel [VSOP]"
6155a8184,8186
> "O89100-1","RefSeq","NP_034945.1","26895103","High GADS expression is associated with neoplasms."
> "O89100-1","RefSeq","NP_034945.1","25037454","The combined loss of Gads and CD127 reveals a novel function of Gads prior to T cell receptor beta expression"
> "O89100-1","RefSeq","NP_034945.1","23399893","GADS mediates lymphoid disease downstream of BCR-ABL through the recruitment of specific signaling intermediates."
6161a8193
> "Q6NVF9-1","RefSeq","NP_001013409.1","18032416","Pre-messenger RNA cleavage factor I (CFIm): potential role in alternative polyadenylation during spermatogenesis. GeneRIF: Here we report that the CFIm subunits NUDT21/CPSF5 and CPSF6 are highly enriched in mouse male germ cells relative to somatic cells."
6188c8220,8225
< "P21237-1","RefSeq","NP_001041604.1","17149751","Distinct tissue-specific expression profiles of each of mouse 5' exon-specific transcripts in different brain regions and nonneural tissues."
---
> "Q99MK9-1","RefSeq","NP_062687.1","31086178","Study show that hypoxia promotes stabilization of RASSF1A through NOX-1- and protein kinase C- dependent phosphorylation. HIF-1alpha activates RASSF1A transcription via HIF-binding sites in the RASSF1A promoter region. RASSF1A binds to HIF-1alpha, blocks its prolyl-hydroxylation and proteasomal degradation. Study concludes that RASSF1A-HIF-1alpha forms a feedforward loop driving hypoxia signaling in pulmonary hypertens... Publication Status: Online-Only"
> "Q99MK9-1","RefSeq","NP_062687.1","29735543","The authors found that haploinsufficiency of Rassf1a was sufficient to dramatically enhance the tumorigenicity of K-Ras in the system."
> "Q99MK9-1","RefSeq","NP_062687.1","29382819","RASSF1A is expressed in differentiating stem cells.RASSF1A promotes YAP and p73 binding to differentiation related genes.RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73. Publication Status: Online-Only"
> "Q99MK9-1","RefSeq","NP_062687.1","27765918","Beta-catenin was predominantly associated with Na+/H+ exchanger regulating factor 1 (NHERF1) in a dynamic context and an increase of its oncogenic function through RAS-association domain family 1, isoform A (RASSF1A) inactivation in liver metastases."
> "Q99MK9-1","RefSeq","NP_062687.1","15665283","Deletion of this gene increases cancer susceptibility in mice."
> "Q8JZX6-1","RefSeq","NP_694877.2","29042196","The anti- DCIR3 antibody established in this study, together with the previously established anti-DCIR1 and anti-DCIR4 antibodies, would be a valuable tool to investigate biology and pathophysiology of monocytes."
6189a8227,8230
> "P36423-1","RefSeq","NP_035669.3","30300909","This study shows that genetic depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor signaling prevents microvascular dysfunction in ischemia reperfusion injury"
> "P36423-1","RefSeq","NP_035669.3","26974824","The administration of salted drinking water (2.7% NaCl) to wild-type mice resulted in elevated placental TXA2 synthase (TXAS) and plasma thromboxane A2, but not prostacyclin, levels, which was also found in clinical preeclampsia placenta samples. Publication Status: Online-Only"
> "P36423-1","RefSeq","NP_035669.3","24009185","12-HHT is produced by both TxAS-dependent and TxAS-independent pathways in vitro and in vi"
> "P36423-1","RefSeq","NP_035669.3","20383787","TXAS mRNA expression was increased within the vascular wall in mouse models of atherosclerosis with advanced lesions."
6194a8236,8240
> "P09056-1","RefSeq","NP_032527.1","30996350","Findings reveal a function of LIF in pancreatic ductal adenocarcinoma tumorigenesis, and suggest its translational potential as an attractive therapeutic target and circulating marker; studies underscore how a better understanding of cell-cell communication within the tumour microenvironment can suggest novel strategies for cancer therapy"
> "P09056-1","RefSeq","NP_032527.1","30270531","The results provide direct evidence for LIF as a major cachexia initiating factor for the C26 tumour in vivo. Tumour-derived LIF was also a regulator of multiple cytokines in C26 tumour cells and in C26 tumour-bearing mice."
> "P09056-1","RefSeq","NP_032527.1","29391217","The amplitude of inward currents in Muller cells from the postischemic retina was reduced to 51% in wild type and to 70% in LIF(-/-) mice. This demonstrates that decrease of inward currents takes place in reactive Muller cells even in the absence of LIF."
> "P09056-1","RefSeq","NP_032527.1","29222114","Blood-derived vitronectin (VTN) rapidly and potently activates leukemia inhibitory factor (LIF) and pro-inflammatory interleukin 6 (IL-6) in vitro and after vascular injury in the brain. Publication Status: Online-Only"
> "P09056-1","RefSeq","NP_032527.1","29721979","An existing single Muller cell microarray dataset was used to determine which processes are upregulated in Muller cells that express LIF, by correlating LIF expression to the expression of other genes using a robust correlation method. Some enriched processes include divalent inorganic cation homeostasis, negative regulation of stem cell proliferation, and gamma-glutamyl transferase activity."
6200a8247,8250
> "Q8BFU1-1","RefSeq","NP_080520.2","26208885","ZIP9/Gna11 interactions mediate the non-classical testosterone signaling cascade in spermatogenic GC-2 cells."
> "Q8CA95-1","RefSeq","NP_035996.2","27058446","A knock-in mouse model carrying the homologous p.Tyr97Cys variant had decreased striatal PDE10A and also displayed motor abnormalities"
> "Q8CA95-1","RefSeq","NP_035996.2","16769090","Findings suggest that PDE10A is involved in regulating striatal output, possibly by reducing the sensitivity of medium spiny neurons to glutamatergic excitation"
> "Q8CA95-1","RefSeq","NP_035996.2","14751289","Striatal phosphodiesterase mRNA and protein levels are reduced in Huntington's disease transgenic mice prior to the onset of motor symptoms."
6206a8257
> "Q31615-1","RefSeq","NP_034527.1","15821084","3.4 A structure of the murine gammadelta TCR G8 bound to its major histocompatibility complex (MHC) class Ib ligand, T22"
6212,6213c8263,8268
< "Q5DW34-1","RefSeq","NP_001012536.2","28992061","The euchromatic lysine methyltransferase GLP regulates heterochromatin organization and myogenic differentiation. Interestingly, GLP represses expression of the methyl-binding protein MeCP2 that induces heterochromatin clustering during differentiation."
< "Q5DW34-1","RefSeq","NP_001012536.2","16702210","Wiz plays a major role in G9a/GLP heterodimer formation in cultured stem cells."
---
> "Q9JHG7-1","RefSeq","NP_064668.2","30514491","PI3Kgamma aggravates the progression of early tuberculosis infection and reduces the frequency of CD4+IL-17+ cells, the production of IL-17 ex vivo as well as gene and protein expression of molecules associated with Th17 cell differentiation."
> "Q9JHG7-1","RefSeq","NP_064668.2","30176533","The lack of PI3Kgamma favors M1 macrophages polarization providing an inflammatory-prone environment, which does not prevent kidney diseases progression."
> "Q9JHG7-1","RefSeq","NP_064668.2","29666415","Deficient mice in the canonical PI3Kgamma signaling (Pik3cg-/-) are more susceptible to T. cruzi infection. The canonical PI3Kgamma signaling in myeloid cells restricts heart parasitism and avoids heart damage and death of mice. Publication Status: Online-Only"
> "Q9JHG7-1","RefSeq","NP_064668.2","28963139","As blockade of PI3Kgamma or integrin alpha4 prevents accumulation of myeloid-derived suppressor cells and reduces myeloid cell expression of immunosuppressive factors that stimulate tumor immune escape, these results highlight PI3Kgamma and integrin alpha4 as targets for the design of cancer therapeutics."
> "Q9JHG7-1","RefSeq","NP_064668.2","29038423","Phosphatidylinositol-3-kinases (PI3K) gamma and delta are key regulators of T cell signaling. Here the author show, using mouse heart allograft transplantation models, that PI3Kgamma or PI3Kdelta deficiency prolongs graft survival, but selective inhibition of PI3Kgamma or PI3Kdelta reveals alternative transplant survival outcomes post CTLA4-Ig treatment. Publication Status: Online-Only"
> "P98084-1","RefSeq","NP_031487.1","27268412","Results indicate that both X11 and X11L exert largely in brain neurons, but X11 may also function in peripheral tissues."
6216a8272,8277
> "P56198-1","RefSeq","NP_848460.1","30361435","A CIDEC domain that regulates LD fusion activity"
> "P56198-1","RefSeq","NP_848460.1","30400015","Growth hormone-induced lipolysis is secondary to its reduction in the expression of FSP27."
> "P56198-1","RefSeq","NP_848460.1","29454584","LXRalpha positively regulates Fsp27a and Fsp27b expression."
> "P56198-1","RefSeq","NP_848460.1","28656280","The role of gp78 and cidec in hepatic steatosis, were investigated."
> "P56198-1","RefSeq","NP_848460.1","17884815","FSP27/Cidec as a novel adipocyte lipid droplet protein that negatively regulates lipolysis and promotes triglyceride accumulation."
> "P28047-1","RefSeq","NP_033554.3","30498093","Long noncoding RNA OIP5-AS1 targets Wnt-7b to affect glioma progression via modulation of miR-410. Publication Status: Online-Only"
6226a8288,8289
> "Q8K2I3-1","RefSeq","NP_061369.2","24792439","Data indicate that in contrast to FMO2 and FMO4, FMO1 is highly expressed in metabolic tissues, including liver, kidney, white adipose tissue (WAT) and brown adipose tissue (BAT)."
> "Q8K2I3-1","RefSeq","NP_061369.2","11835629","Sequencing, expression, and characterization of cDNA"
6245a8309,8314
> "Q4ZJM9-1","RefSeq","NP_001019873.1","30367035","The secreted complement C1q-like protein 4 repress myoblast fusion by specifically interacting with G protein-coupled receptor BAI3. Publication Status: Online-Only"
> "Q4ZJM9-1","RefSeq","NP_001019873.1","23449976","These results implicate CTRP11 as a novel secreted regulator of adipogenesis and highlight the potential paracrine cross-talk between adipocytes and cells of the stromal vascular compartment in maintaining adipose tissue homeostasis."
> "Q9ET26-1","RefSeq","NP_109668.2","28625874","These data suggested the potential physiological function of RNF114 in inflammation and host antiviral responses, but demonstrate complexity in the regulation of innate immunity by ubiquitin ligases."
> "Q9ET26-1","RefSeq","NP_109668.2","28073917","Our study uncovers that RNF114-mediated ubiquitination and degradation of TAB1 activate the NF-kappaB pathway during MZT, and thus directly link maternal clearance to early embryo development."
> "Q9ET26-1","RefSeq","NP_109668.2","23645206","ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.)."
> "Q9ET26-1","RefSeq","NP_109668.2","17394778","Present data suggests that Znf313 gene might play a fundamental role in gene transcription and regulation and relates to spermatogenesis."
6250a8320,8322
> "Q8BRB7-1","RefSeq","NP_059507.2","29268844","Silence of lysine acetyltransferase 6B (KAT6B) suppressed lipopolysaccharide(LPS)-induced IL-6 production in peritoneal macrophages."
> "Q8BRB7-1","RefSeq","NP_059507.2","22951486","Data indicate that Myst4, Jmjd2b, Aof1 genes are regulated by H3K9me under hyperinsulinemia/hyperglycemia."
> "Q8BRB7-1","RefSeq","NP_059507.2","11782361","Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase and deacetylase activities in murine skin and tumors."
6266a8339,8341
> "Q3UNX5-1","RefSeq","NP_997607.2","25744306","Data suggest that expression of Acsm3 in adipose tissue can be regulated by dietary factors; here, expression of Acsm3 in white adipose tissue is down-regulated in obesity caused by high-fat diet."
> "Q3UNX5-1","RefSeq","NP_997607.2","12707288","Analysis of the role of the SA gene in blood pressure regulation."
> "P84444-1","RefSeq","NP_035254.1","28611158","Data indicate the nonredundant role of chemokine (C-C motif) ligand 21A (serine) (CCL21Ser)-encoding Ccl21a in the establishment of self-tolerance in T cells in the thymic medulla"
6267a8343,8347
> "O08644-1","RefSeq","NP_031706.3","28262839","Using an EphB6 mouse knockout model we found that the loss of EphB6 does not initiate intestinal tumorigenesis and is not involved in the early tumor progression through the adenoma-to-carcinoma transition. Publication Status: Online-Only"
> "Q06138-1","RefSeq","NP_598542.3","29269522","MiR-144/451 facilitates recovery from acute anemia by repressing Cab39/AMPK/mTOR"
> "Q06138-1","RefSeq","NP_598542.3","24811174","Cab39 differentially interacts with WNK4 and SPAK/OSR1 to switch the classic two kinase cascade into a signal kinase transduction"
> "Q06138-1","RefSeq","NP_598542.3","22844503","Elevated miR-195 targets the LKB1/AMPK signaling axis in hypertrophic cardiomyopathy"
> "Q06138-1","RefSeq","NP_598542.3","21903876","Quantitative PCR revealed significantly reduced LKB1, MO25alpha, and STRADbeta mRNA in LKB1(-/-) muscle. These findings demonstrate that the LKB1-MO25-STRAD complex is the principal AMPKK in skeletal muscle."
6270a8351,8359
> "Q8R4G6-1","RefSeq","NP_660110.2","29720442","Deficiency in Branched Glycosylation in MGAT5 Null or Heterozygous Mice Is Associated with Early-Onset Disease and Increased Severity of Colitis>"
> "Q91ZS8-1","RefSeq","NP_570965.2","29694894","PKCzeta/ADAR2 axis is a critical regulator of colorectal cancer metastases through modulation of miR-200 levels."
> "Q91ZS8-1","RefSeq","NP_570965.2","28640668","FMRP inhibits ADAR2 activity, absence of FMRP results in defects of RNA editing of neuronal mRNAs in the mouse model of Fragile X Syndrome."
> "Q91ZS8-1","RefSeq","NP_570965.2","28395340","ADARB1 mediates adenosine to inosine RNA editing in the testis, and these editing events are dispensable for male fertility in an inbred mouse strain in the lab."
> "Q91ZS8-1","RefSeq","NP_570965.2","16382140","ADAR2 autoediting is a key regulator of ADAR2 protein expression and activity in vivo."
> "O35177-1","RefSeq","NP_059492.3","27359298","A new role for Cas-L in T-cell activation, is reported."
> "O35177-1","RefSeq","NP_059492.3","27336669","These results suggest that Nedd9 is a Smad2/3 target gene implicated in RANKL-induced osteoclastogenesis. Publication Status: Online-Only"
> "O35177-1","RefSeq","NP_059492.3","26683084","NEDD9 is required for the maintenance of dendritic spines in the hippocampus."
> "O35177-1","RefSeq","NP_059492.3","16148091","Cas-L affects homeostasis of MZB cells and peripheral lymphoid organs, which is considered to be relevant to impaired lymphocyte migration and adhesion"
6271a8361,8362
> "Q61206-1","RefSeq","NP_032801.2","23238734","Knockdown of PAFAH1B2 strongly reduced Abeta secretion from human cells, and this effect was confirmed in primary cells derived from PAFAH1B2 knock-out mice"
> "Q61206-1","RefSeq","NP_032801.2","19272360","Study examined biochemical interactions of Pafah1b Alpha1 & Alpha2 subunits with the Reelin signaling machinery & demonstrated that Alpha2, but not Alpha1, binds Dab1 in a phosphorylation-independent manner"
6276a8368,8370
> "P14097-1","RefSeq","NP_038680.1","29739756","Alternatively-activated macrophages-secreted MIP-1beta activates CCR5/PI3K signaling in mesothelial cells, resulting in expression of P-selectin on the mesothelial cell surface. Tumor cells attached to this de novo P-selectin through CD24. C57/BL6 mice treated with MIP-1beta exhibited increased P-selectin expression on mesothelial cells lining peritoneal tissues, which enhanced CaOV3 adhesion ex vivo and ID8 adhesion i..."
> "P14097-1","RefSeq","NP_038680.1","28092793","High dilutions of antimony modulate cytokines production and macrophage - Leishmania (L.) amazonensis interaction in vitro.("
> "Q9R0M6-1","RefSeq","NP_062747.1","25220469","Crystal structure of the Rab9A-RUTBC2 Rab-binding domain complex reveals that the hypervariable region of Rab9A is not required for RUTBC2 binding."
6281a8376,8378
> "P59384-1","RefSeq","NP_001316349.1","25349050","Results show that ADAMTS15 and ADAMTS4 not only exhibit unique cellular expression patterns in the brain but their developmental upregulation by these cell types coincides with critical aspects of neural development"
> "P59384-1","RefSeq","NP_001316349.1","25510509","Spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts15 in mice."
> "P59384-1","RefSeq","NP_001316349.1","24220035","These data suggest a role for ADAMTS15 in a wide range of biological processes that are potentially mediated through the processing of versican."
6286d8382
< "Q3U1J1-1","RefSeq","NP_001277310.1","17041757","Although p53 is a main regulator of apoptosis in mammalian cells, the Tfpt induced apoptosis appears p53-independent."
6291a8388,8392
> "Q924X7-1","RefSeq","NP_473444.1","29155043","Stk33 protein resides in the cytoplasm and partially co-localizes with the caudal end of the manchette, a transient structure that guides tail elongation, in elongating spermatids, and loss of Stk33 leads to the appearance of a tight, straight and elongated manchette."
> "Q924X7-1","RefSeq","NP_473444.1","25398772","STK33 plays an essential role in hepatocellular proliferation and liver tumorigenesis. STK33 may bind directly to c-Myc and increase its transcriptional activity."
> "Q924X7-1","RefSeq","NP_473444.1","24057876","Double-immunostaining experiments with antibodies against Stk33 and vimentin showed a striking colocalization of Stk33 and vimentin in the hypothalamus."
> "Q924X7-1","RefSeq","NP_473444.1","19490892","STK33 promotes cancer cell viability in a kinase activity-dependent manner by regulating the suppression of mitochondrial apoptosis mediated through S6K1-induced inactivation of the death agonist BAD selectively in mutant KRAS-dependent cells."
> "Q924X7-1","RefSeq","NP_473444.1","16176263","STK33/Stk33 expression pattern resembles those of some related members of the calcium/calmodulin dependent kinase group"
6293d8393
< "Q8BP71-1","RefSeq","NP_444334.3","30867288","RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure"
6298a8399,8403
> "Q8VCK6-1","RefSeq","NP_666299.1","30203438","FFAR2 directly mediates both the stimulatory effects of Sodium acetate and Sodium propionate on insulin secretion and their protection against islet apoptosis. We have also shown that Short chain fatty acids coupling in islets occurs via Gq-coupled intracellular signaling."
> "Q8VCK6-1","RefSeq","NP_666299.1","30201970","Graft-versus-host disease protective effect of short-chain fatty acids requires GPR43-mediated ERK phosphorylation and activation of the NLRP3 inflammasome in non-hematopoietic target tissues of the host Publication Status: Online-Only"
> "Q8VCK6-1","RefSeq","NP_666299.1","18499755","A potential role for GPR43 in regulating plasma lipid profiles and perhaps aspects of metabolic syndrome."
> "Q8VCK6-1","RefSeq","NP_666299.1","16123168","Acetate and propionate short chain fatty acids may have important physiological roles in adipogenesis through GPCR43, but not through GPCR41."
> "Q8VCK6-1","RefSeq","NP_666299.1","12393494","Induced by the activation of STAT3; might play pivotal role in differentiation and immune response of monocytes and granulocytes"
6303a8409,8412
> "Q9Z1K6-1","RefSeq","NP_035920.1","25895533","HOXA10 gene disruption exhibited an overwhelming and fatal emergency granulopoiesis response that was characterized by tissue infiltration with granulocytes, but reversed by re-expression of Triad1 in the bone marrow."
> "Q9Z1K6-1","RefSeq","NP_035920.1","23179078","Essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system"
> "Q9Z1K6-1","RefSeq","NP_035920.1","21454682","HoxA10 influences protein ubiquitination by activating transcription of ARIH2, the gene encoding Triad1"
> "Q9Z1K6-1","RefSeq","NP_035920.1","16118314","Proteasomal degradation of proteins that are ubiquitinated by Triad1 affects the clonogenic growth of primary myeloid progenitor cells"
6315a8425,8436
> "Q8K3K8-1","RefSeq","NP_862896.1","30017954","Reduced TBK1 activation and IFN-beta production in primary microglia frommouse model in which the Ub-binding region of optineurin was deleted (Optn(470T)) upon Toll-like receptor stimulation. Also diminished expression and activation of several transcription factors that support the amplification loop for IFN-beta production including STAT1, IRF7 and IRF9."
> "Q8K3K8-1","RefSeq","NP_862896.1","29684153","Findings suggest that changes in their accumulation, determined via quantitative comparison of the OPTN foci and IBs in the cells, are involved in pathological features of ALS"
> "Q8K3K8-1","RefSeq","NP_862896.1","29367621","OPTN may be a potential antisenescence factor in diabetic nephropathy. Publication Status: Online-Only"
> "Q8K3K8-1","RefSeq","NP_862896.1","28882891","These results suggest that the IRAK1-binding protein OPTN negatively regulates IL-1beta/LPS-induced NF-kappaB activation by preventing polyubiquitination of TRAF6."
> "Q8K3K8-1","RefSeq","NP_862896.1","16569640","Mutated form of optineurin, E50K, identified in normal tension loses its ability to translocate to the nucleus and when overexpressed compromises the mitochondrial membrane integrity resulting in cells that are less fit to survive under stress conditions"
> "Q8K3K8-1","RefSeq","NP_862896.1","15607428","Optn colocalizes with vesicular structures near the nucleus and is expressed in anterior segment, retina, and optic nerve blood vessels."
> "Q8BN78-1","RefSeq","NP_064652.2","31221066","The proposed mechanisms for the increase in the efficiency of somatic reprogramming associated with the Kaiso gene knockout is a decrease in the methylation level of the Oct4 promoter region in mouse embryonic fibroblasts before reprogramming."
> "Q8BN78-1","RefSeq","NP_064652.2","28882591","We also demonstrate that Kaiso inhibits Znf131 expression, raising the possibility that Kaiso and Znf131 act to fine-tune target gene expression. Together, our findings implicate Znf131 as a co-regulator of Kaiso-mediated biological processes."
> "Q8BN78-1","RefSeq","NP_064652.2","26955760","Kaiso and Sox10 sequentially interact with Tcf7l2 to coordinate the maturation of oligodendrocyte. Publication Status: Online-Only"
> "Q8BN78-1","RefSeq","NP_064652.2","26454239","Study revealed the involvement of the Zbtb33 gene and, probably, the Kaiso protein in the regulation of locomotion and brain morphology in mice"
> "Q8BN78-1","RefSeq","NP_064652.2","15543138","P120-catenin and Kaiso are essential components of a new developmental gene regulatory pathway that controls vertebrate morphogenesis."
> "Q8BN78-1","RefSeq","NP_064652.2","15282317","These results provide the first experimental evidence that rapsyn is a direct sequence-specific target of Kaiso and delta-catenin."
6318a8440,8441
> "Q920H4-1","RefSeq","NP_991352.2","24573284","This study demonistrated that activation of M5 receptors in the striatum induces an inhibition in dopamine release."
> "Q920H4-1","RefSeq","NP_991352.2","11900778","Mutant mice with a deletion in the third intracellular loop of the muscarinic M5 receptor gene exhibited increased drinking compared to wild-type, but feeding was not increased."
6324a8448,8452
> "Q8CI15-1","RefSeq","NP_079643.2","29673590","The cell division gene PCNA was significantly overexpressed in SK2(-/-) cells, suggesting a cross regulation between sphingosine kinases and Ceramide glucosyltransferase."
> "Q8CI15-1","RefSeq","NP_079643.2","17643421","Sphingosine kinase 1 is a component of the copper-dependent FGF1 release pathway."
> "Q8CI15-1","RefSeq","NP_079643.2","16623665","Results suggest that export of Sphk-1a isoform occurs under physiological conditions and may contribute to the establishment of the vascular S1P gradient."
> "Q8CI15-1","RefSeq","NP_079643.2","16368679","SPHK1a and SPHK1b differ in enzymatic traits including stability, localization, modification, and oligomerization."
> "Q8CI15-1","RefSeq","NP_079643.2","12391145","Data describe a novel mechanism by which vascular endothelial growth factor induces DNA synthesis in a pathway where sphingosine kinase mediates signaling from protein kinase C to Ras in a manner independent of Ras-guanine nucleotide exchange factor."
6333a8462,8469
> "Q80W85-1","RefSeq","NP_851990.2","28600324","Findings demonstrate that the NPM2-based oocyte nucleolus is an essential platform for parental chromatin organization in early embryonic development."
> "Q80W85-1","RefSeq","NP_851990.2","21415138","Involved in sperm chromatin remodeling"
> "Q80W85-1","RefSeq","NP_851990.2","18324673","Promoter activities of three mouse maternal genes (H1oo, Npm2, and Zar1) in oocytes and pre-implantation embryos, and examined the promoters and to obttain the best promoter for oocytte gene expression."
> "Q80W85-1","RefSeq","NP_851990.2","12714744","Npm2 is a maternal effect gene critical for nuclear and nucleolar organization and embryonic development"
> "Q3UMB5-1","RefSeq","NP_780700.1","29950492","C9ORF72 and SMCR8 have interdependent functions in suppressing autoimmunity as well as negatively regulating lysosomal exocytosis-processes of potential importance to amyotrophic lateral sclerosis."
> "Q3UMB5-1","RefSeq","NP_780700.1","27875531","These results demonstrate that the C9orf72-SMCR8 protein complex functions in the regulation of metabolism and provide evidence that loss of C9orf72 function may contribute to the pathogenesis of relevant diseases Publication Status: Online-Only"
> "Q3UMB5-1","RefSeq","NP_780700.1","27617292","We created Smcr8 knockout mice and found that Smcr8 mutant cells exhibit impaired autophagy induction, which is similarly observed in C9orf72 knockdown cells. Mechanistically, SMCR8/C9ORF72 interacts with the key autophagy initiation ULK1 complex and regulates expression and activity of ULK1 Publication Status: Online-Only"
> "Q62371-1","RefSeq","NP_072075.2","28700752","Circulating fibroblast precursors expressing DDR2, in an exposure-induced model of pulmonary fibrosis, is reported. Publication Status: Online-Only"
6345a8482,8485
> "Q8CIV7-1","RefSeq","NP_694455.2","30413481","Simultaneous deletion of Zeb1 encoding an EMT-promoting factor restores directional migration to Ovol2-deficient Bu-HFSCs. Taken together, our findings highlight the important function of an Ovol2-Zeb1 EMT-regulatory circuit in controlling the directional migration of epithelial stem and progenitor cells to facilitate adult skin epithelial regeneration and repair."
> "Q8CIV7-1","RefSeq","NP_694455.2","27310661","Association of a chromosomal rearrangement event with mouse posterior polymorphous corneal dystrophy and alterations in Csrp2bp, Dzank1, and Ovol2 gene expression have been reported. Publication Status: Online-Only"
> "Q8CIV7-1","RefSeq","NP_694455.2","26619963","OVOL2 is a colorectal tumor suppressor that blocks WNT signaling by facilitating the recruitment of histone deacetylase 1 to the TCF4-beta-catenin complex."
> "Q8CIV7-1","RefSeq","NP_694455.2","12213202","Ovol2 transcription was dramatically reduced in testes from blind-sterile mice, suggesting that Ovol2 is expressed in male germ cells"
6351a8492
> "P63085-1","RefSeq","NP_036079.1","30909920","Combined treatment of PA and LPS in RAW264.7 cells mimics the situation of diabetes with obesity that has higher level of PA and LPS, MAPK/TLR4/ MCP-1 might be potential therapeutic targets for diabetes with obesity. Publication Status: Online-Only"
6352a8494,8501
> "Q9D9Z5-1","RefSeq","NP_079876.1","28211159","The results indicate that DDA1 promotes lung cancer progression, potentially through promoting cyclins and cell cycle progression."
> "Q91V57-1","RefSeq","NP_786928.2","28346224","These findings reveal a role for ephrin bidirectional signaling upstream of mutant alpha2-chimaerin in Duane retraction syndrome, which may contribute to the selective vulnerability of abducens motor neurons in this disorder"
> "Q91V57-1","RefSeq","NP_786928.2","17719550","Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of Efnb3 forward signaling"
> "Q91V57-1","RefSeq","NP_786928.2","16446429","Lpha1-chimaerin is an activity-regulated Rho GTPase regulator that is activated by phospholipase Cbeta-coupled cell surface receptors and contributes to pruning of dendritic arbors"
> "Q91V57-1","RefSeq","NP_786928.2","15447672","Chimaerin, one of the Rho GTPase activating proteins, is transcriptionally up-regulated after exposure to neurotrophins in post-natal cerebellar neurons."
> "Q91XL2-1","RefSeq","NP_542985.4","25712254","Conclude that LNX2 regulates M-CSF/RANKL and the Notch signaling pathways during osteoclastogenesis"
> "Q91XL2-1","RefSeq","NP_542985.4","25279559","Caspr4 inhibits neuronal differentiation in a LNX-dependent manner."
> "Q91XL2-1","RefSeq","NP_542985.4","15979067","Coxsackievirus and adenovirus receptor is a partner in a protein complex organized at specific subcellular sites by LNX2"
6355,6358d8503
< "A2CG63-1","RefSeq","NP_919238.1","28207192","These results identified ARID4B as a master regulator of a signaling network that governs the establishment of a niche during the critical gonocyte-to-spermatogonial stem cells (SSC) transition phase to control the fate of gonocytes and SSCs."
< "A2CG63-1","RefSeq","NP_919238.1","26258622","The study identified ARID4B to be a key regulator of Sertoli cell function important for male germ cell development."
< "A2CG63-1","RefSeq","NP_919238.1","23487765","ARID4A and ARID4B function as transcriptional coactivators for AR and RB and play an integral part in the AR and RB regulatory pathways involved in the regulation of Sertoli cell function and male fertility."
< "A2CG63-1","RefSeq","NP_919238.1","18728284","10 of 12 Arid4a(-/-)Arid4b(+/-) mice progressed to acute myeloid leukemia (AML) and had rapid further increases of leukocyte counts."
6359a8505
> "P36895-1","RefSeq","NP_033888.2","30692543","Data show that BMP signalling controls venous identity via the bone morphogenetic protein receptor type-1A receptor(ALK3/BMPR1A). Publication Status: Online-Only"
6381,6385c8527,8533
< "Q8BQY8-1","RefSeq","NP_001290461.1","25915840","Whereas Hus1(neo/neo) and Atm(-/-) single mutant mice survived low-dose MMC similar to wild-type controls, Hus1(neo/neo)Atm(-/-) double mutants showed striking MMC hypersensitivity."
< "Q8BQY8-1","RefSeq","NP_001290461.1","23468651","HUS1 acts as a component of the canonical 9-1-1 complex during meiotic prophase I to promote DSB repair and further propose that RAD1 and TOPBP1 respond to unsynapsed chromatin through an alternative mechanism that does not require RAD9 or HUS1."
< "Q8BQY8-1","RefSeq","NP_001290461.1","22575700","Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1"
< "Q8BQY8-1","RefSeq","NP_001290461.1","19918068","Requirement for Hus1 in the survival and proliferation of mammary epithelium"
< "Q8BQY8-1","RefSeq","NP_001290461.1","17220276","Identify differential effects of altered Hus1 gene dosage on genome maintenance during in vitro culture, genotoxic stress responses, embryonic development, and adult homeostasis"
---
> "Q9ESF4-1","RefSeq","NP_075657.1","21614515","In this study, the authors show that TMBIM3 is expressed in the brain including high levels in the hippocampus."
> "Q8R1G6-1","RefSeq","NP_666090.1","29852170","Reducing NF-kappaB activation attenuates PDLIM2 deficiency-exacerbated inflammation and dyslipidemia in Palmitate -treated primary hepatocytes."
> "Q8R1G6-1","RefSeq","NP_666090.1","28315683","Klotho can modulate inflammation via PDLIM2/NF-kappaB p65 pathway in cyclosporine A-induced nephropathy."
> "Q8R1G6-1","RefSeq","NP_666090.1","22155789","Deficiency in PDLIM2 resulted in the accumulation of STAT3 in the nucleus, enhanced the extent of TH17 cell differentiation, and exacerbated granuloma formation. Publication Status: Online-Only"
> "Q8R1G6-1","RefSeq","NP_666090.1","17468759","PDLIM2 deficiency resulted in larger amounts of nuclear p65, defective p65 ubiquitination and augmented production of proinflammatory cytokines in response to innate stimuli"
> "Q8R1G6-1","RefSeq","NP_666090.1","15963787","SLIM is a novel ubiquitin E3 ligase whose targets include STAT proteins."
> "Q8R1G6-1","RefSeq","NP_666090.1","15659642","Knockdown of Mystique 2 with small interfering RNA abrogated both adhesion and migration in MCF10A and MCF-7 cells"
6399a8548,8550
> "D2J0Y4-1","RefSeq","NP_001186870.1","20843368","FATS expression was silent or downregulated in human cancers, and overexpression of FATS suppressed tumorigenicity in vivo independently of p53. Results reveal FATS as a p53-regulated gene to monitor genomic stability. Publication Status: Online-Only"
> "P81069-1","RefSeq","NP_766100.1","22862946","The findings identify the tetramer-forming GABPbeta2 as specific HSC regulators and potential therapeutic targets in treating LSC-based hematological malignancy."
> "P81069-1","RefSeq","NP_766100.1","18628204","GABPbeta2 has a distinct role in restraining B cell expansion and humoral responses."
6401,6403c8552,8563
< "Q0VGM9-1","RefSeq","NP_001160137.1","29290468","Rtel1 binds to and inhibits restart of reversed replication forks within telomeres, which compromises replication and leads to critically short telomeres."
< "Q0VGM9-1","RefSeq","NP_001160137.1","24115439","RTEL1 plays a critical role in both telomere and genome-wide replication, which is crucial for genetic stability and tumor avoidance."
< "Q0VGM9-1","RefSeq","NP_001160137.1","22593209","Propose that mRtel1 is a key protein for DNA replication, recombination, and repair and efficient elongation of telomeres by telomerase"
---
> "O54972-1","RefSeq","NP_796263.1","30560907","Study reveals a complex pattern of gene regulation by SCL, ETO2 and RYBP. Genome-wide analyses shows locus-specific binding of ETO2 and RYBP on SCL's 778 activated and repressed genes. Publication Status: Online-Only"
> "O54972-1","RefSeq","NP_796263.1","25957903","Gene deficient mice have decreased levels of systemic monocytes and infarct-associated macrophages and display compromised tissue healing and post-MI heart failure"
> "O54972-1","RefSeq","NP_796263.1","25573176","MTG16 loss promotes radioresistance and impacts intestinal stem cell function, possibly due to shifting cellular response away from DNA damage-induced apoptosis and towards DNA repair after injury."
> "O54972-1","RefSeq","NP_796263.1","16407974","The dynamics of ETO2 recruitment within nuclear complexes couple cell proliferation to cell differentiation and determine the onset of terminal erythroid maturation."
> "O54972-1","RefSeq","NP_796263.1","16287841","Association with T-cell acute lymphocytic leukemia 1, ETO-2 represses gene expression in the early stages of erythroid differentiation"
> "D3YZU1-1","RefSeq","NP_001029287.1","30053575","SHANK1 plays a role in neocortical learning-induced dendritic spine plasticity underlying learning and normal cognition; and in mechanisms mediating abnormalities of impaired cognition."
> "D3YZU1-1","RefSeq","NP_001029287.1","28963042","A review: Shank1 knockout mouse model for autism spectrum disorder (ASD) displays moderate impairments in (I) social behavior, (II) communication, and (III) repetitive and stereotyped patterns of behavior, together with (IV) aberrant cognitive phenotypes, consistent with the symptoms present in humans diagnosed with ASD and carrying SHANK1 deletions. Review article"
> "D3YZU1-1","RefSeq","NP_001029287.1","29218848","Study demonstrates that SHANK1 is developmentally expressed in hippocampal neurons and glial cells. Although the specific role for this developmental expression pattern in these different cell types is not fully understood, the current study provides the first developmental cell-type-specific expression profile."
> "D3YZU1-1","RefSeq","NP_001029287.1","18272690","These results affirm the importance of Shank1 for synapse structure and function in vivo, and they highlight a differential role for Shank1 in specific cognitive processes."
> "O70552-1","RefSeq","NP_062366.2","30335155","Using the 3'-UTRs of mouse Cpeb1, Btg4 and Cnot6l mRNAs, we deciphered the combinatorial code that controls developmental stage-specific translation during meiotic maturation"
> "O70552-1","RefSeq","NP_062366.2","27605379","Study reports that a complex of BTG4 and CAF1 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs"
> "O70552-1","RefSeq","NP_062366.2","27190313","BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis"
6408,6410c8568,8570
< "P70196-1","RefSeq","NP_001290202.1","30392071","MiR-590-3p has the ability to suppress LPS-induced Acute Kidney Injury and podocyte apoptosis by targeting TRAF6"
< "P70196-1","RefSeq","NP_001290202.1","30190125","The expression of TRAF6 in T cells might be implicated in tissue-specific sialadenitis by regulating the chemokine-chemokine receptor system"
< "P70196-1","RefSeq","NP_001290202.1","30103950","The data suggest that TFAF6 inhibition reduces choroidal neovascularization formation via down-regulating expression of HIF-1a and VEGF and activation of macrophages and microglia."
---
> "Q61539-1","RefSeq","NP_036064.3","31036938","Restoration of a polymorphic ESRRB motif using CRISPR-Cas9 in a hybrid ESC line restores ESRRB binding and enhancer H3K27ac in an allele-specific manner but has no effect on chromatin interactions Erratum:[Nat Cell Biol. 2019 May 16;:. PMID: 31097792]"
> "Q61539-1","RefSeq","NP_036064.3","30275266","Esrrb extinction triggers dismantling of naive pluripotency and marks commitment to differentiation."
> "Q61539-1","RefSeq","NP_036064.3","29129686","The resulting cells express the components of the core transcriptional network of mESCs, including ESRRB, at high levels, which suggests the existence of naive-state hiPSCs that are similar to mESCs. We also demonstrate that these cells differentiate more readily into neural cells than do conventional hiPSCs."
6441a8602,8608
> "Q7TSD4-1","RefSeq","NP_075551.3","24361585","Spatial, through its transport by Kif17, is crucial for neuronal polarization."
> "Q7TSD4-1","RefSeq","NP_075551.3","20937703","Tbata modulates thymus function by regulating stromal cell proliferation via the Nedd8 pathway."
> "Q7TSD4-1","RefSeq","NP_075551.3","19918778","Data show that Spatial expression is independent of thymocyte-derived signals during thymus organogenesis."
> "Q7TSD4-1","RefSeq","NP_075551.3","17961552","These findings suggest that Spatial may play a role in neuronal morphogenesis and synaptic plasticity through its interaction with the kinesin motor KIF17 in dendrites."
> "Q7TSD4-1","RefSeq","NP_075551.3","17196196","Together, these findings imply a function of Spatial in spermatid differentiation as a new cargo of kinesin KIF17b, in a microtubule-dependent mechanism specific to the manchette and the principal piece of the sperm tail."
> "Q7TSD4-1","RefSeq","NP_075551.3","15236666","A new short thymus isoform, Spatial-beta, differs from other isoforms by an additional alternative exon of 69 bases. This new exon encodes an interesting proline-rich signature that could confer to the 34 kDa Spatial-beta protein a particular function. Publication Status: Online-Only"
> "Q7TSD4-1","RefSeq","NP_075551.3","11196687","Provides evidence for non-AUG translation initiation site"
6449c8616,8619
< "Q6P8Y7-1","RefSeq","NP_001333951.1","24914955","These data support a model in which SNX31 mediates the endocytic degradation of uroplakins. Publication Status: Online-Only"
---
> "Q3U9N9-1","RefSeq","NP_082523.1","29535325","We report hearing loss in mice with mutations in Slc16a2 and a related gene Slc16a10 (Mct10, Tat1). Deficiency of both transporters results in retarded development of the sensory epithelium similar to impairment caused by hypothyroidism, compounded with a progressive degeneration of cochlear hair cells and loss of endocochlear potential. Publication Status: Online-Only"
> "Q3U9N9-1","RefSeq","NP_082523.1","24248460","Mct10 participates in tissue-specific TH transport and also contributes to the generation of the unusual serum TH profile characteristic for Mct8 deficiency"
> "Q3U9N9-1","RefSeq","NP_082523.1","17273864","The aromatic amino acid diffusion pathway TAT1 can control neutral amino acid efflux via neighboring exchanger LAT2-4F2hc, by recycling its aromatic influx substrates"
> "Q3U9N9-1","RefSeq","NP_082523.1","16245314","TAT1 is a basolateral epithelial transporter and can function as a net efflux pathway for aromatic amino acids. We propose that it may supply parallel exchangers with recycling uptake substrates that could drive the efflux of other amino acids."
6453a8624,8625
> "O54851-1","RefSeq","NP_034420.2","29476948","The increased Cx36 immunopositive product in mossy fibers at the chronic stage after PISE may enhance the contacts between granule cells in the dentate gyrus and pyramidal neurons in CA3 area."
> "Q99J94-1","RefSeq","NP_076207.1","26385979","Results suggest that genetic variation in Slco1a6 leads to altered transport of taurocholic acid and potentially other bile acids) by pancreatic islets, resulting in broad gene regulation"
6456,6458c8628,8631
< "P37242-1","RefSeq","NP_001106888.1","29753845","Data suggest that gestational/maternal endocrine disruptor DEHP [di-(2-ethylhexyl) phthalate] exposure dose-dependently causes fetal IUGR (intrauterine growth restriction); mRNA levels of placental Thra1 and Thrb1 are reduced and nuclear translocation of placental Thra1 and Thrb1 is suppressed in DEHP-exposed mice."
< "P37242-1","RefSeq","NP_001106888.1","29895698","Thyroid hormone receptor beta1 stimulates ABCB4 to increase biliary phosphatidylcholine excretion"
< "P37242-1","RefSeq","NP_001106888.1","29945885","Transcriptome and ChIP-seq analyses and found that many genes that were co-regulated by both THRB1 and ESRRA were involved in mitochondrial metabolic pathways. Publication Status: Online-Only"
---
> "Q9ER04-1","RefSeq","NP_109634.2","17918741","Mouse spinesin is involved in function of astrocytes in spinal cord and there may be astrocyte-specific regulation of its gene expression."
> "Q9ER04-1","RefSeq","NP_109634.2","15465023","Data report a newly isolated serine protease from mouse CNS, homologous to human spinesin type II transmembrane serine protease 5 and present as a full-length protein as well as type 1, 2, and 3 variants."
> "P48756-1","RefSeq","NP_032145.2","30400014","Inhibition of hydrolysis of carbohydrates by alpha-glucosidase inhibitors in the gut reduces GIP secretion through a microbiota/SCFA/FFAR3 pathway"
> "P48756-1","RefSeq","NP_032145.2","29800682","Pancreatic cancer-derived exosomes (Exo-Mia) suppress the synthesis of GIP and GLP-1 from STC-1cells in vitro by down-regulating the PCSK1/3"
6460,6464d8632
< "Q9CWZ3-1","RefSeq","NP_001095877.1","28916722","Data suggest that, in embryonic stem cells, Gsk3b/Gsk3a phosphorylate splicing factors (Rbm8a, Srsf9, and Psf) and nucleolar proteins (Npm1 and Phf6); Gsk3b/Gsk3a are key to alternative splicing of close to 190 genes. (Gsk3 = glycogen synthase kinase-3; Rbm8a = RNA binding motif protein 8a; Srsf9 = splicing factor, arginine-serine-rich 9; Psf = replication protein Psf; Npm1 = nucleophosmin 1; Phf6 = PHD finger protein 6)"
< "Q9CWZ3-1","RefSeq","NP_001095877.1","28404883","Our data demonstrate that miR-29a regulates the proliferation and differentiation of RPCs by directly targeting Rbm8a, providing us with a better understanding of the molecular mechanisms that govern RPC proliferation and differentiation."
< "Q9CWZ3-1","RefSeq","NP_001095877.1","27618312","We first show that Eif4a3 haploinsufficiency phenocopies aberrant neurogenesis and microcephaly of Magoh and Rbm8a mutant mice.we show that genetic ablation of one downstream pathway, p53, significantly rescues microcephaly of all 3 EJC mutant Publication Status: Online-Only"
< "Q9CWZ3-1","RefSeq","NP_001095877.1","26094033","This data suggests a novel role of RBM8a in the regulation of neurodevelopment. Publication Status: Online-Only"
< "Q9CWZ3-1","RefSeq","NP_001095877.1","23638902","This is the first study that demonstrates the key role of RBM8a on the emotional behaviors in mice."
6468a8637
> "P35330-1","RefSeq","NP_034624.1","28939548","Data show that intercellular adhesion molecule 1 (ICAM-1) and ICAM-2 on B cells are essential for long-lasting cognate T follicular helper (Tfh)-B cell interactions and efficient selection of low-affinity B cell clones for proliferative clonal expansion."
6472a8642,8648
> "P70671-1","RefSeq","NP_058545.1","30878284","Apoptotic caspases control innate immunity and maintain immune homeostasis against viral infection, suppressing type I interferon production via the cleavage of cGAS, MAVS, and IRF3"
> "P70671-1","RefSeq","NP_058545.1","12444163","Activation of transcription factor IFN regulatory factor 3, the synthesis of large amounts of IFN-beta mRNA, and IFN-alpha/beta signal transduction in macrophages infected with Listeria monocytogenes"
> "P70671-1","RefSeq","NP_058545.1","11940575","Direct involvement of CREB-binding protein/p300 in sequence-specific DNA binding of virus-activated interferon regulatory factor-3 holocomplex."
> "P70671-1","RefSeq","NP_058545.1","11854279","Role in regulating expression of ISG15-specific protease UBP43 in conjunction with lipopolysaccharide"
> "Q80ZM8-1","RefSeq","NP_079922.2","22584571","Transgenic expression of cardiolipin synthase attenuated maladaptive cardiolipin remodeling and bioenergetic inefficiency in myocardium rendered diabetic by streptozotocin treatment."
> "Q80ZM8-1","RefSeq","NP_079922.2","20652826","CLS mRNA levels cannot be correlated with CLS enzyme activity nor CL content in the LPS model of inflammation."
> "Q80ZM8-1","RefSeq","NP_079922.2","18454555","CL has roles in in neuronal signaling, mitochondrial bioenergetics, and apoptosis"
6477a8654,8656
> "P27814-1","RefSeq","NP_032553.2","30995786","Nkrp1 isoforms c1, c2 and f were expressed prevalently as homodimers, whereas the Nkrp1a displays larger proportion of monomers on the cell surface. Publication Status: Online-Only"
> "P27814-1","RefSeq","NP_032553.2","30374346","Data suggest that expression of killer cell lectin-like receptor subfamily B member 1C protein (NK1.1) defines a population of rapidly expanding effector CD4(+) T cells that specifically promote plasmablast induction during Plasmodium infection. Publication Status: Online-Only"
> "P27814-1","RefSeq","NP_032553.2","28224733","The adoptive transfer of NK1.1(-) CD4(+) NKG2D(+) cells suppressed DSS-induced colitis largely dependent on TGF-beta. Thus, NK1.1(-) CD4(+) NKG2D(+) cells exhibited immune regulatory functions, and this T cell subset could be developed to suppress inflammation in clinics."
6492,6494d8670
< "Q923X4-1","RefSeq","NP_001033681.1","29274570","Ur results demonstrate that the GRX2-mediated regulation of O2(*-)/H2O2 release through the S-glutathionylation of mitochondrial proteins may play an integral role in controlling cellular ROS signaling"
< "Q923X4-1","RefSeq","NP_001033681.1","29101900","Grx2 absence impairs mitochondrial fusion, ultrastructure and energetics in primary cardiomyocytes and cardiac tissue."
< "Q923X4-1","RefSeq","NP_001033681.1","28618115","Study shows that Grx2 detoxifies *NO in mature oligodendrocytes and oligodendroglial precursor cellsvia the formation of dinitrosyl-iron-complexes, inhibiting the formation of harmful peroxynitrite and reducing subsequent oligodendroglial damage. Findings link inorganic biochemistry to neuroinflammation and identify glutaredoxin 2 as a protective factor against neuroinflammation-mediated myelin damage."
6500c8676,8684
< "Q62418-1","RefSeq","NP_001139780.1","22450813","MAbp1 is of fundamental importance for spreading and migration under shear stress conditions, which are critical prerequisites for efficient PMN extravasation during inflammation."
---
> "Q06219-1","RefSeq","NP_038641.1","30267803","The pathogenesis of cerebral ischemia-reperfusion injury is associated with Nurr1 upregulation followed by augmented mitochondrial fission via an abnormal YAP-INF2 pathways"
> "Q06219-1","RefSeq","NP_038641.1","30111648","NR4A1/Nur77 and NR4A2/Nurr1 dynamically regulated inflammatory gene expression in glia by modulating the transcriptional activity of NF-kappaB."
> "Q9ERV7-1","RefSeq","NP_073145.1","28432080","NPM1-dependent nucleolar PIDDosome is a key initiator of the caspase-2 activation cascade."
> "Q9ERV7-1","RefSeq","NP_073145.1","27643878","PIDD acts as a critical switcher between the NF-kappabeta transcription pathway and radiation-induced apoptosis"
> "Q9ERV7-1","RefSeq","NP_073145.1","25857265","The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd"
> "Q9ERV7-1","RefSeq","NP_073145.1","23238565","Loss of PIDD leads to an impaired inflammatory response after DNA damage."
> "Q9ERV7-1","RefSeq","NP_073145.1","19575295","PIDD does not play an essential role for all p53-mediated or p53-independent apoptotic pathways."
> "Q9ERV7-1","RefSeq","NP_073145.1","19364921","Results suggest that at least one alternative PIDDosome-independent mechanism of caspase-2 activation exists in mammals in response to DNA damage."
> "Q9ERV7-1","RefSeq","NP_073145.1","11695552","P450 levels were higher in female DES-treated p53+/- mice compared to treated wild type mice. Review article"
6508,6514c8692,8695
< "Q91ZD6-1","RefSeq","NP_001106872.1","29029019","Data show that p53 and EAF2 knockout mice developed prostate cancer."
< "Q91ZD6-1","RefSeq","NP_001106872.1","26935903","These results demonstrate that EAF2-mediated apoptosis in GC B cells limits excessive humoral immune responses and is important for maintaining self-tolerance. Publication Status: Online-Only"
< "Q91ZD6-1","RefSeq","NP_001106872.1","26328919","The results showed that Eaf2 knockout can reduce UV-induced apoptosis in crystalline lenses and mitigate the formation of cataracts."
< "Q91ZD6-1","RefSeq","NP_001106872.1","24260246","Mice deficient in EAF2 had an increased recovery rate and a decreased overall response to the effects of androgen deprivation. Publication Status: Online-Only"
< "Q91ZD6-1","RefSeq","NP_001106872.1","17873910","Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia"
< "Q91ZD6-1","RefSeq","NP_001106872.1","17892859","Transcriptional activation mediated by FESTA/EAF2, a transcription factor that interacts with S-II, was decreased in RNA polymerase II deficient embryonic stem cells."
< "Q91ZD6-1","RefSeq","NP_001106872.1","14517999","Expression of Eaf2 is developmentally regulated."
---
> "Q99M51-1","RefSeq","NP_035008.2","26659946","In mice with Nck1/2 deletions, endothelial cells fail to develop front-rear polarized vessel sprouts."
> "Q99M51-1","RefSeq","NP_035008.2","26621720","These results reveal that Nck regulates preosteoblastic/osteoblastic migration and bone mass."
> "Q99M51-1","RefSeq","NP_035008.2","26434994","Nck1 silencing in pancreatic beta cells promotes PERK activation and signaling to protect beta cells against pathological stresses."
> "Q99M51-1","RefSeq","NP_035008.2","25995205","Nck proteins not only participate in thymic selection and generation of the peripheral T cell repertoire but also are involved in the differentiation and effector functions of CD4(+) T cells."
6519c8700,8702
< "Q920B0-1","RefSeq","NP_001333566.1","29947801","His study reveals a critical role of FRMD4B in maintaining ELM integrity and in rescuing morphological abnormalities of the outer nuclear layer in photoreceptor dysplasia."
---
> "P17095-2","RefSeq","NP_057869.2","29867121","Findings highlight a novel FoxO1/HMGA1-mediated mechanism by which insulin may regulate gene expression and metabolism. Publication Status: Online-Only"
> "P17095-2","RefSeq","NP_057869.2","29316384","HMGA1 expression was closely correlated with the clinical stage, histological grade, and tumor size in breast cancer patients and breast cancer progression in transgenic MMTV-PyMT mice"
> "P17095-2","RefSeq","NP_057869.2","29101051","G9a has a novel role in modulating insulin signaling, at least in part, depending on its regulatory function on HMGA1"
6522a8706
> "Q9WVP1-1","RefSeq","NP_033808.2","23684748","AP-1B is required for protein sorting and polarization of intestinal cells in mice. Loss of AP-1B in the intestinal epithelia results in mislocalization of E-cadherin, activation of beta-catenin/Tcf4 complex, proliferation, and hyperplasia."
6534a8719,8726
> "Q9JKV9-1","RefSeq","NP_067355.1","28125663","Our data suggest that IL-20 subfamily cytokines, particularly IL-20, IL-22, and IL-24, might provide therapeutic benefit for patients with Diabetic foot ulcers (DFU) . Publication Status: Online-Only"
> "Q9JKV9-1","RefSeq","NP_067355.1","27075747","The authors conclude that IL-20 affects bone formation and downregulates osteoblastogenesis by modulating sclerostin, osterix, RUNX2, and osteoprotegerin on osteoblasts. Publication Status: Online-Only"
> "Q9JKV9-1","RefSeq","NP_067355.1","26176762","IL-20 is primarily up regulated in psoriatic skin at the post-transcriptional level."
> "Q9JKV9-1","RefSeq","NP_067355.1","26162095","Data show that interleukin 20 (IL-20) is expressed in type 2 diabetic db/db islets and contributes to inflammation. Publication Status: Online-Only"
> "Q9JKV9-1","RefSeq","NP_067355.1","22238453","Our results suggest that IL-20 plays pivotal roles in the tumor progression of breast cancer. IL-20 expression in breast cancer tissue is associated with a poor clinical outcome."
> "Q9JKV9-1","RefSeq","NP_067355.1","17878297","IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs"
> "Q9JKV9-1","RefSeq","NP_067355.1","16778121","IL-20 is a proatherogenic cytokine that contributes to the progression of atherosclerosis."
> "Q61467-1","RefSeq","NP_033602.2","15465018","Results describe the molecular properties of Zic4 and Zic5 proteins."
6539,6541c8731,8740
< "Q5DTL9-1","RefSeq","NP_001229309.1","24905082","Finding show that somatodendritic expression of Slc4a10 undergoes neuron type- and input pathway-dependent regulation in adult brains"
< "Q5DTL9-1","RefSeq","NP_001229309.1","15567717","NCBE is expressed in the peripheral nervous system and in non-neuronal tissues as the choroid plexus, the dura, and some epithelia including the acid secreting epithelium of the stomach and the duodenal epithelium."
< "Q5DTL9-1","RefSeq","NP_001229309.1","14592810","SLC4A10 gene product and NBCn1 both function as basolateral HCO3- entry pathways and that the SLC4A10 gene product may be responsible for the stilbene-sensitive Na+-HCO3- uptake that is essential for cerebrospinal fluid production."
---
> "Q6TXD4-1","RefSeq","NP_082305.1","23403554","Taken together, these results provide evidence that interaction of InlC with host Tuba is important for full virulence."
> "Q6TXD4-1","RefSeq","NP_082305.1","16757518","Tuba-stimulated dorsal ruffling might represent a novel mechanism for the coordination of N-WASP-dependent cytoskeletal rearrangements, and Tuba function is implicated in motility processes."
> "Q8BX17-1","RefSeq","NP_766146.2","25911097","This work both reveals a new autoregulatory pathway governing SMN expression, and identifies a new mechanism through which SMN can modulate specific mRNA expression via Gemin5."
> "Q6ZPI3-1","RefSeq","NP_742166.1","29663375","Long noncoding RNA H19 mediates LCoR to regulate the balance between osteogenic and adipogenic differentiation of mBMSCs in mice through sponging miR-188."
> "Q6ZPI3-1","RefSeq","NP_742166.1","28972158","LCoR negatively regulates early adipogenesis by repressing C/EBP beta transcriptional activity and add LCoR to the growing list of transcriptional corepressors of adipogenesis."
> "Q6ZPI3-1","RefSeq","NP_742166.1","28530657","MiR-199a promotes stem cell properties in mammary stem cells and breast cancer stem cells by directly repressing nuclear receptor corepressor LCOR, which primes interferon responses."
> "Q6ZPI3-1","RefSeq","NP_742166.1","25366156","These findings suggest that transactivation activities of Mlr1 and Mlr2 are differentially regulated by splicing variants of NOL4, which are expressed in a tissue-selective manner."
> "Q6ZPI3-1","RefSeq","NP_742166.1","12560079","Identification and characterization of Mlr2 a homolog of Mblk-1, a transcription factor from the honeybee brain; expressed in various tissues other than testis"
> "Q99LI2-1","RefSeq","NP_663518.1","30157172","Clcc1+/- KO mice showed decreased electroretinogram and photoreceptor number. Intracellular chloride transport by CLCC1 is a critical process in maintaining retinal integrity, and CLCC1 is crucial for survival and function of retinal cells. Publication Status: Online-Only"
> "Q99LI2-1","RefSeq","NP_663518.1","25698737","This study demonistrated that Loss of Clcc1 results in ER stress, misfolded protein accumulation, and neurodegeneration."
6550a8750,8752
> "Q9JII5-1","RefSeq","NP_573451.2","23965306","Identification of Crem, Crisp2 and Pot1a as the natural substrates of DAZAP1 and show that DAZAP1 promotes the inclusion of specific exons in these genes."
> "Q9JII5-1","RefSeq","NP_573451.2","23658607","The translation of the two Dazap1 transcripts is differentially regulated during spermatogenesis. Publication Status: Online-Only"
> "Q9JII5-1","RefSeq","NP_573451.2","18669443","DAZAP1 is not only essential for spermatogenesis, but also required for the normal growth and development of mice."
6555a8758,8759
> "Q62137-1","RefSeq","NP_034719.2","29986854","Partial trisomy 21 contributes to T-cell malignancies induced by JAK3-activating mutations in murine models."
> "Q62137-1","RefSeq","NP_034719.2","29308566","Blockade of JAK1-JAK3 accelerated, and selective inactivation of STAT3 decelerated differentiation of progenitor cells."
6574,6575d8777
< "Q8BXA0-1","RefSeq","NP_001297515.1","27225731","These results suggest that postsynaptic SALM5 promotes synapse development by trans-synaptically interacting with presynaptic LAR-RPTPs and is important for the regulation of excitatory synaptic strength. Publication Status: Online-Only"
< "Q8BXA0-1","RefSeq","NP_001297515.1","27152329","We identified herpes virus entry mediator as a functional receptor that mediates SALM5's suppressive function. Our findings reveal a molecular link between the neuronal system and the immune system, and provide potential therapeutic targets for the control of CNS diseases. Publication Status: Online-Only"
6592a8795,8800
> "Q99J99-1","RefSeq","NP_619611.3","27038311","Up-regulation of 3-MST was located in living neurons and followed neuronal autophagy after traumatic brain injury."
> "Q99J99-1","RefSeq","NP_619611.3","27748832","The findings of this study indicate that a deficiency in 3MST does not significantly affect endotoxemia, while a deficiency in CBS or CSE slightly ameliorates the outcome of LPS-induced endotoxemia in vivo."
> "Q99J99-1","RefSeq","NP_619611.3","26519030","3-Mercaptopyruvate sulphurtransferase and not cystathionine gamma-lyase is the primary regulator of coronary artery hydrogen sulfide production and function."
> "Q99J99-1","RefSeq","NP_619611.3","26437775","H2S3 and H2S are produced in the brain by 3-mercaptopyruvate sulfurtransferase. Publication Status: Online-Only"
> "Q99J99-1","RefSeq","NP_619611.3","23104984","SiRNA silencing of 3-MPST reduced basal bioenergetic parameters and prevented the stimulating effect of 3-MP on mitochondrial bioenergetics."
> "Q99J99-1","RefSeq","NP_619611.3","23759691","Behavioral abnormality in MST-KO mice is caused by MST function defects such as an antioxidant insufficiency or a new transducer, H2S (or HS(-)) and/or SOx deficiency."
6595a8804,8805
> "Q5RKZ7-1","RefSeq","NP_082740.1","15862276","Inactivity results in elevated sulfite and diminished sulfate levels throughout the organism, and various brain dysmorphisms."
> "P10754-1","RefSeq","NP_035877.1","20231359","Data suggest that Rhit acts as a repressor in the heat-induced and age-dependent transcriptional regulation of the (S) isoform of Mpv17-like protein."
6618a8829,8832
> "Q8BGV8-1","RefSeq","NP_848834.2","27076521","MiD51 can suppress Mff-dependent enhancement of Drp1 GTPase activity."
> "Q8BGV8-1","RefSeq","NP_848834.2","26101352","This paper combines confocal live-cell imaging with correlative cryogenic fluorescence microscopy and soft x-ray tomography to link MiD49 and MiD51 to the involvement of the endoplasmic reticulum in mitochondrial fission."
> "Q8BGV8-1","RefSeq","NP_848834.2","24508339","ADP is an essential cofactor for MiD51 during mitochondrial fission."
> "Q8BGV8-1","RefSeq","NP_848834.2","23921378","MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and suggest that they provide specificity to the division of mitochondria."
6634,6639c8848,8853
< "Q80VW7-1","RefSeq","NP_001038979.1","21606955","Targeted deletions of mouse AKNA, a hypothetical AT-hook-like transcription factor, sensitize mice to pathogen-induced inflammation and cause sudden neonatal death"
< "Q3TEA8-1","RefSeq","NP_001116369.1","27460150","Hp1bp3 and associated molecular networks are modulators of cognitive aging. GeneRIF: Loss of Hp1bp3 expression is associated with cognitive decline in both mice and humans."
< "Q3TEA8-1","RefSeq","NP_001116369.1","27470444","Hp1bp3(-/-) females showed no deficits in behaviors often associated with impaired maternal care, including social behavior, depression, motor coordination and olfactory capability; and maintained unchanged anxiety-associated hallmarks such as cholinergic status and brain miRNA profiles. Results suggest a novel role for HP1BP3 in regulating maternal and anxiety-related behavior in mice"
< "Q3TEA8-1","RefSeq","NP_001116369.1","26976970","Study identified Hp1bp3 overexpression as a potential novel marker for intrinsic 5-5-Fluorouracil resistance in colon cancer ."
< "Q3TEA8-1","RefSeq","NP_001116369.1","26402843","HP1BP3 plays a key role in normal growth and bone development by regulating transcription of endocrine IGF-1 components. GeneRIF: HP1BP3 regulates hepatic expression of IGF-1 and its binding proteins, thus regulating the endocrine IGF-1 pathway."
< "Q3TEA8-1","RefSeq","NP_001116369.1","25662603","The results suggest that HP1BP3 is a ubiquitous histone H1 like nuclear protein with distinct and non-redundant functions necessary for survival and growth."
---
> "Q8BRT1-1","RefSeq","NP_001273532.1","28550165","The novel protein SOGA1 was confirmed to colocalize with a microtubule-associated protein CLASP2 and with tubulin, which identifies SOGA1 as a new microtubule-associated protein."
> "Q8BRT1-1","RefSeq","NP_001273532.1","28285824","Data reveal that CLASP2 is an essential Reelin effector orchestrating cytoskeleton dynamics during brain development."
> "Q8BRT1-1","RefSeq","NP_001273532.1","28069833","These findings reveal a new role for Clasp2 in governing keratinocyte undifferentiated features."
> "Q3U5C7-1","RefSeq","NP_001028389.1","30590023","Necrotic eyelid debris plays an important role in ocular pathogenesis of the Prickle 1 mutant mouse, which may represent a type of non-infectious keratoconjunctivitis caused by damaged autologous tissues."
> "Q3U5C7-1","RefSeq","NP_001028389.1","28935237","Prickle1 plays a role in positive regulation of differentiation and maturation of oligodendrocytes."
> "Q3U5C7-1","RefSeq","NP_001028389.1","17868671","Mouse Prickle1 and Prickle2 possibly regulate positive neurite formation during brain development"
6644a8859,8864
> "P15702-1","RefSeq","NP_033285.1","30226896","Data provide evidence for an important role of CD43 in modulating immune dysregulation and mortality following sepsis. Publication Status: Online-Only"
> "P15702-1","RefSeq","NP_033285.1","27011118","Glycosylation status of CD43 protein on leukemia cells is associated with sensitivity to CTL-mediated cytolysis Publication Status: Online-Only"
> "P15702-1","RefSeq","NP_033285.1","26700769","Findings demonstrate that CD43 is a major E-selectin ligand in Th17 cells that functions independent of P-selectin glycoprotein ligand-1"
> "Q9D9R7-1","RefSeq","NP_083654.1","16488114","Dmrt8.1 mRNA was detected in Sertoli cells by in situ hybridization."
> "Q01405-1","RefSeq","NP_033173.2","30065114","These data demonstrate an equivalent function for SEC23A/B, with evolutionary shifts in the transcription program likely accounting for the distinct phenotypes of SEC23A/B deficiency within and across species, a paradigm potentially applicable to other sets of paralogous genes."
> "Q01405-1","RefSeq","NP_033173.2","28259758","This study also validated the interaction between HAP1 and Sec23A using co-immunoprecipitation experiments with endogenous proteins. This manuscript also reports on the high confidence interacting partners of HAP1 identified by the non-biased approach used in this study, which interestingly, consists of predominantly trafficking-related proteins"
6656a8877,8878
> "Q3UTY6-1","RefSeq","NP_766032.1","21880733","ADAMTSL6beta has a role in fibrillin-1 microfibril formation"
> "Q3UTY6-1","RefSeq","NP_766032.1","19940141","Results indicated that ADAMTSL-6 is a novel microfibril-associated protein that binds directly to fibrillin-1 and promotes fibrillin-1 matrix assembly."
6662a8885,8899
> "Q9Z2X8-1","RefSeq","NP_057888.1","31017694","MiR-1225 is significant in multiple malignancies and other pathological reactions; transfection of a miR-1225 mimic or Keap1 silencing inhibits osteoclastogenesis; after miR-1225 inhibition and Keap1 overexpression, TNF was increased; TNFalpha overexpression promoted Keap1 depletion-inhibited BMM osteoclastogenesis; miR-1225 activates Keap1-Nrf2-HO-1 signal to inhibit TNFalpha-induced osteoclastogenesis"
> "Q9Z2X8-1","RefSeq","NP_057888.1","30896860","Silencing Keap1 was able to reverse the inhibitory effect of Axitinib and enhance the protein expressions of Nrf2, NAD(P)H dehydrogenase [quinone] 1 and heme oxygenase 1."
> "Q9Z2X8-1","RefSeq","NP_057888.1","30622671","The results from this study suggest a novel function of miR-24-3p in protecting cardiomyocytes from ischemia/reperfusion injury by the activation of the Nrf2-Keap1 pathway. Publication Status: Online-Only"
> "Q9Z2X8-1","RefSeq","NP_057888.1","30538709","DC32 significantly suppressed rheumatoid arthritis (RA) via the Nrf2-p62-Keap1 feedback loop. Publication Status: Online-Only"
> "Q9Z2X8-1","RefSeq","NP_057888.1","12193649","Evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants"
> "P0C090-1","RefSeq","NP_001094061.1","29246441","Roquin-mediated control of PI3K-mTOR signaling prevents autoimmunity by restraining activation and differentiation of conventional T cells and specialization of Treg cells."
> "P0C090-1","RefSeq","NP_001094061.1","23663784","Study demonstrates that the constitutive decay element folds into an RNA stem-loop motif that is specifically recognized by Roquin and Roquin2. Binding of Roquin initiates degradation of TNF-alpha mRNA and limits TNF-alpha production in macrophages."
> "P0C090-1","RefSeq","NP_001094061.1","23583643","Roquin-1 and Roquin-2 proteins redundantly repressed the mRNA of inducible costimulator (Icos) and identified the Ox40 costimulatory receptor as another shared mRNA target."
> "P0C090-1","RefSeq","NP_001094061.1","23583642","RING-deficient Roquin-1 failed to localize to stress granules and allowed Roquin-2 to compensate in the repression of ICOS and Tfh cells."
> "P0C090-1","RefSeq","NP_001094061.1","10938276","Characterization of the human RC3H2 ortholog and observation of conserved sequences in mouse."
> "Q8K1K9-1","RefSeq","NP_751894.2","27609454","Induction of Hinfp begins at the 4-cell stage. Maternally encoded Hinfp sustains development of pre-implantation stage embryos. Hinfp loss delays growth of blastocyst stage embryos that later fail to implant. Hinfp ablation severely reduces histone H4 mRNA and causes DNA damage. Transmission of maternal Hinfp transcripts and zygotic activation of the Hinfp gene together are neeeded to control early H4 gene expression."
> "Q8K1K9-1","RefSeq","NP_751894.2","26030398","Simultaneous loss of both Hinfp and the p53 checkpoint is detrimental to normal cell growth and may predispose to cellular transformation."
> "Q8K1K9-1","RefSeq","NP_751894.2","24797072","Data show that conditional ablation of HINFP compromises cell proliferation, impairs DNA synthesis, alters nucleosome spacing and increases double-stranded DNA damage."
> "Q8K1K9-1","RefSeq","NP_751894.2","21605641","The in vivo co-expression of Hinfp and histone H4 genes is consistent with the biological function of Hinfp as a principal transcriptional regulator of histone H4 gene expression during mouse development."
> "Q8K1K9-1","RefSeq","NP_751894.2","17826007","The dependence of HiNF-P gene transcription on cyclin E/CDK2/p220NPAT signaling defines a novel feed-forward loop that may sustain HiNF-P expression in proliferating cells to support the cell cycle regulated synthesis of histone H4 proteins."
6664a8902
> "Q5DTV4-1","RefSeq","NP_001156393.1","18178554","MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a, Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage activation."
6667a8906
> "Q922Y1-1","RefSeq","NP_666205.1","15944415","Specific interaction of rat protein 2B28 with rat Homer2 may play a role in regulation of protein degradation by ubiquitin-proteasome systems and that this function may be specific to Homer2 proteins among Homer family proteins."
6675a8915,8921
> "Q91VF2-1","RefSeq","NP_536710.1","29162912","KO mice exhibited high aggressive behaviours and exhibited prolonged bouts of awakening during the light (inactive) period and compensatory sleep during the dark (active) period. Publication Status: Online-Only"
> "Q91VF2-1","RefSeq","NP_536710.1","19162242","Decreasing expression over the time course of the skin pathological changes in MRL/lpr mice Review article"
> "Q91VF2-1","RefSeq","NP_536710.1","11855681","Genomic structure of the rat and mouse histamine N-methyltransferase gene"
> "Q6NZL8-1","RefSeq","NP_073560.2","30414502","SCUBE1 directly binds to BMP7 and its receptors, functioning as a BMP co-receptor to promote BMP7 signaling."
> "Q6NZL8-1","RefSeq","NP_073560.2","20042401","SCUBE1 may be involved in the regulation of tubular cell proliferation and re-epithelialization during the resolution of kidney injury."
> "Q6NZL8-1","RefSeq","NP_073560.2","19101956","During tooth development, Scube1 localized to the dental papilla of both incisor and molar teeth, suggestina a role for Scube1 during early craniofacial development."
> "Q6NZL8-1","RefSeq","NP_073560.2","18303018","These results support the dual roles of SCUBE1 on brain morphogenesis and cell-cell adhesions through its distinct domain function."
6677a8924,8925
> "Q6AW69-1","RefSeq","NP_080875.3","29016873","Demonstrate a functional relevance for cingulin-like 1 as a defining factor in new vessel formation both in vitro and in vivo"
> "Q6AW69-1","RefSeq","NP_080875.3","15292197","JACOP is involved in anchoring the apical junctional complex, especially TJs, to actin-based cytoskeletons."
6683a8932,8933
> "P17183-1","RefSeq","NP_038537.1","28508170","Study analyzed the regions that regulate the promoter strength and cellular specificity of the 1.8 kb rNSE promoter in the cerebellum in vivo. The rNSE promoter was divided into three regions (A, B, and C). Our results showed that region C was indispensable for the promoter activity in mouse cerebellum and served as an interneuron-predominant basal promoter."
> "Q8C0P7-1","RefSeq","NP_598578.1","27343429","A regulatory role of ZNF451-1 in fine-tuning physiological PML levels"
6692,6696c8942
< "O35732-1","RefSeq","NP_001276633.1","29191940","The antagonistic caspase 8-homolog cFLIP is a critical regulator of acute, cholestatic liver injury."
< "O35732-1","RefSeq","NP_001276633.1","29099934","Caspase-8 synergizes with the canonical NLRP3 inflammasome pathway to control caspase-1 processing and IL-1beta maturation, providing a regulatory role for caspase-8 in host resistance to in vivo Paracoccidioides brasiliensis infection."
< "O35732-1","RefSeq","NP_001276633.1","28850249","Deletion of c-FLIP from CD11b(hi) Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis."
< "O35732-1","RefSeq","NP_001276633.1","29107687","In conclusion, our data indicated that miR-150 potentially contributes to the hepatic steatosis and insulin resistance in NAFLD. miR-150/CFLAR pathway may be a new therapeutic strategy against NAFLD."
< "O35732-1","RefSeq","NP_001276633.1","28218919","Findings establish CFLAR as a key suppressor of steatohepatitis and indicate that the development of CFLAR-peptide-mimicking drugs and the screening of small-molecular inhibitors that specifically block ASK1 dimerization are new and feasible approaches for NASH treatment. Erratum:[Nat Med. 2017 Oct 6;23 (10 ):1241. PMID: 28985205]"
---
> "Q2WF71-1","RefSeq","NP_085039.2","18585462","Data show that the C-terminal PDZ binding domains of synaptic adhesion-like molecules (SALMs)1-3 are required for neurite outgrowth, and that the N-termini of SALMs 2 and 4 are alsoinvolved in neurite outgrowth."
6698,6701d8943
< "Q3UUG6-1","RefSeq","NP_001157319.1","30335140","We then further investigated TBC1D24 haploinsufficiency in vivo and demonstrate that TBC1D24 is also crucial for normal presynaptic function: genetic disruption of Tbc1d24 expression in the mouse leads to an impairment of endocytosis and an enlarged endosomal compartment in neurons with a decrease in spontaneous neurotransmission."
< "Q3UUG6-1","RefSeq","NP_001157319.1","24729547","That the p.Ser178Leu mutation of TBC1D24 is a probable cause for dominant, nonsyndromic hearing impairment. Identification of TBC1D24 as the stereocilia-expressing gene may shed new light on its specific function in the inner ear."
< "Q3UUG6-1","RefSeq","NP_001157319.1","20797691","A pathogenic mutation was identified in TBC1D24."
< "Q3UUG6-1","RefSeq","NP_001157319.1","20727515","Two compound heterozygous missense mutations (D147H and A509V) in TBC1D24, a gene of unknown function, are responsible for familial infantile myoclonic epilepsy."
6713,6717d8954
< "Q80U16-1","RefSeq","NP_083955.1","30254631","Results show that Fam65b expression and phosphorylation can finely tune the amount of active RhoA in order to favor optimal T lymphocyte motility. Publication Status: Online-Only"
< "Q80U16-1","RefSeq","NP_083955.1","27269051","RhoC co-localizes with Fam65b in stereocilia and regulates Fam65b oligomerization what is critical for hair cell function. Publication Status: Online-Only"
< "Q80U16-1","RefSeq","NP_083955.1","25588844","These data together elucidate a mechanism for RHOA and pMLC polarization in stimulated neutrophils through direct inhibition of RHOA by FAM65B at the leading edge."
< "Q8R4G0-1","RefSeq","NP_109624.1","28074533","Decreased Ntng1 expression was initially observed in the nucleus accumbens of mice conditioned to cocaine."
< "Q8R4G0-1","RefSeq","NP_109624.1","11906208","Selectively expressed in distinct neuronal subsets that include populations in forebrain, midbrain, hindbrain, spinal cord, and spinal ganglia"
6728a8966,8967
> "Q61767-1","RefSeq","NP_032320.1","19172483","Present in the lymphoid organs after immunization with soluble antigen"
> "Q61767-1","RefSeq","NP_032320.1","22217834","Data suggest that newly synthesized protein(s) are required for cAMP induction of Hsd3b4 and CYP17 mRNA levels (but not of CYP11A mRNA levels). [REVIEW] Review article"
6733a8973,8975
> "Q8CI32-1","RefSeq","NP_081680.1","25367796","Knockdown of Bag5 exacerbated Abeta1-42-induced apoptosis."
> "Q8CI32-1","RefSeq","NP_081680.1","24475098","BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. Publication Status: Online-Only"
> "Q8CI32-1","RefSeq","NP_081680.1","15603737","Bcl-2-associated athanogene 5 (BAG5) is a negative regulator of both Hsp70 and parkin function that sensitizes dopaminergic neurons to injury-induced death."
6740a8983,8984
> "P29477-1","RefSeq","NP_035057.1","30790510","Study enables us to conclude that beta-cell stress is aggravated by the incapability of STAT5B to induce Nos2 resulting in HO accumulation and the ensuing oxidative stress enhances beta-cell damage."
> "P29477-1","RefSeq","NP_035057.1","30622540","Study highlights the crucial role of iNOS, whose activity is required for the anti-fibrotic properties of mesenchymal stem cells in experimental systemic sclerosis, with a special emphasis on NO-related anti-oxidant functions. Publication Status: Online-Only"
6761a9006,9009
> "Q9D9R0-1","RefSeq","NP_080577.1","28476934","Study identifies new gene-type zinc finger protein 125 (RNF125) as a negative regulator of TRIM14 in the innate antiviral immune response"
> "Q9D9R0-1","RefSeq","NP_080577.1","26202983","Data indicate that brain from Japanese encephalitis virus (JEV)-infection showed a reciprocal correlation between microRNA miR-15b levels and the expression of ring finger protein 125 (RNF125)."
> "Q9D9R0-1","RefSeq","NP_080577.1","17460044","RNF125 is enhanced by IFN, these functions constitute a negative regulatory loop circuit for IFN production"
> "Q61207-1","RefSeq","NP_035309.3","28972074","Data show that matrix (ECM) stiffness leads to mechano-signal transduction in mesenchymal stem cells (MSC), which promotes mammary tumor growth in part through secretion of the signaling protein prosaposin."
6765a9014,9017
> "P41438-1","RefSeq","NP_112473.1","15579899","Existence of four unique noncoding exons and promoters for mRFC and demonstrate a facile induction of mRNAs for mRFC and multidrug resistance-associated proteins 1 and 3 in intestine in response to changes in dietary folate intake"
> "P41438-1","RefSeq","NP_112473.1","12832086","Interaction between the E45 and K404 residues in the first and 11th transmembrane domains; the E45 residue appears to be the more dominant determinant of binding and anion sensitivity"
> "Q8BVE3-1","RefSeq","NP_598587.2","29782852","Partial loss of ATP6V1H inhibits osteogenic differentiation and promotes adipogenic differentiation of bone marrow stromal cells."
> "Q8BVE3-1","RefSeq","NP_598587.2","28970149","Differences between two isoforms using bioinformatic methods, as well as some in vitro and in vivo methods in mice and zebrafish; found that two isoforms of H subunit showed the tissue specific locations and the ratio of two subunits might have an important role to control osteoclast function and craniofacial development."
6768a9021,9025
> "Q68FG2-1","RefSeq","NP_067262.1","28173092","Loss of EAAT4 accounts for the initial hyper-excitability of Purkinje cells lacking b-III spectrin and that loss of GLAST appears to work synergistically to worsen motor deficits. When levels of both EAAT4 and GLAST are compromised in b-III(-/-) mice, the proximal dendrites of Purkinje cells within the posterior cerebellum are the most vulnerable to degeneration."
> "Q68FG2-1","RefSeq","NP_067262.1","20231455","BetaIII spectrin disruption impairs synaptogenesis by disturbing the intracellular pathways selectively regulating protein trafficking to the synapse"
> "P63147-1","RefSeq","NP_033484.3","28825854","Results reveal that RAD6B and RNF8 contribute to nucleosome removal during spermiogenesis."
> "P63147-1","RefSeq","NP_033484.3","23863405","These results suggest that Ube2b, as a direct androgen receptor transcriptional target in Sertoli cells, mediates the function of androgen recpetor in spermatogenesis by promoting H2A ubiquitylation. Publication Status: Online-Only"
> "P63147-1","RefSeq","NP_033484.3","23525009","RNF168, in complex with RAD6A or RAD6B, is activated in the DNA-damage-induced protein ubiquitination cascade."
6783a9041,9048
> "Q9R045-1","RefSeq","NP_036053.2","30031603","The ANGPTL2 played an essential role in osteoclast generation through regulating the proliferation and inflammation of osteoclast lineage cells, providing new insights into the therapeutic strategy to alleviate bone loss."
> "Q9R045-1","RefSeq","NP_036053.2","29852175","Angptl2(-/-) in paraquat-treated mice attenuated acute lung injury progression by reducing the number of total cells, total leukocytes, neutrophils and macrophages in bronchoalveolar lavage fluid and reducing inflammatory response through the inactivation of nuclear factor kappa B pathway."
> "Q9R045-1","RefSeq","NP_036053.2","29627690","Kaempferol modulates the expression of ANGPTL2 to lessen the mastitis in mice."
> "Q9R045-1","RefSeq","NP_036053.2","29191837","ANGPTL2 up-regulation in skeletal myocytes accelerates muscle atrophy, and exercise-induced attenuation of ANGPTL2 expression in those tissues may partially explain how exercise training prevents sarcopenia."
> "Q9R045-1","RefSeq","NP_036053.2","28890470","Circulating ANGPTL2 levels increase in mice with heart failure.  Increased circulating ANGPTL2 levels in mice reflect, rather than promote, cardiac dysfunction."
> "Q9R045-1","RefSeq","NP_036053.2","19723494","Angiopoietin-like protein 2 (Angptl2) was secreted by adipose tissue and that its circulating level was closely related to adiposity, systemic insulin resistance, and inflammation in mice."
> "Q9R045-1","RefSeq","NP_036053.2","19553662","Data suggest that interaction of ANG2, a proangiogenic factor, with its receptor Tie2 promotes neural progenitor cell differentiation into neuronal lineage cells."
> "Q9R045-1","RefSeq","NP_036053.2","18514180","This work pinpoints a specific lymphatic defect of Ang2(-/-) mice and further defines the sequential steps in lymphatic vessel remodeling."
6788a9054,9055
> "E9QAM5-1","RefSeq","NP_898985.2","25004093","Expression of Lepr in the liver, but not in the hypothalamus, was up-regulated in Helz2 knockout mice."
> "E9QAM5-1","RefSeq","NP_898985.2","23525231","Thrap3 could play indispensable roles in terminal differentiation of adipocytes by enhancing PPARgamma-mediated gene activation cooperatively with Helz2."
6789a9057,9068
> "Q9D856-1","RefSeq","NP_082368.1","24303081","The zinc transporter Zip5 (Slc39a5) regulates intestinal zinc excretion and protects the pancreas against zinc toxicity. Publication Status: Online-Only"
> "Q9D856-1","RefSeq","NP_082368.1","24039764","ZIP5 is directed to the same subcellular locations as PrP(C) and both proteins are seen to be endocytosed through vesicles decorated with the Rab5 marker protein. Publication Status: Online-Only"
> "Q9D856-1","RefSeq","NP_082368.1","16682017","Temporal and spatial patterns of expression of the mouse ZIP1, 3, 4, and 5 genes in the developing intestine and the effects of maternal dietary zinc deficiency on these patterns of expression were examined"
> "Q9D856-1","RefSeq","NP_082368.1","15322118","Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells"
> "Q9D856-1","RefSeq","NP_082368.1","15358787","ZIP4 and ZIP5 have roles in the adaptive response to dietary zinc in mice [ZIP5]"
> "Q04646-1","RefSeq","NP_439888.1","25633594","FXYD2 activity may be a fundamental mechanism underlying the persistent hypersensitivity to pain induced by inflammation."
> "Q04646-1","RefSeq","NP_439888.1","23344951","Data suggest that in pancreatic beta cells regulatory subunit of Na,K-ATPase FXYD2 plays a role in Akt signaling pathways associated with cell growth and proliferation."
> "Q04646-1","RefSeq","NP_439888.1","22253804","The transcription factor Runx1 controls FXYD2 expression during the maturation of the somato-sensory system, partly through regulation of the tyrosine kinase receptor Ret."
> "Q148V8-1","RefSeq","NP_598848.2","29676651","These findings shed new light on the association of Fam83h and fluorosis and indicated that high fluoride decreased the expression of Fam83h in morphological and cytological development. This may be one of the reasons for the occurrence of fluorosis."
> "Q148V8-1","RefSeq","NP_598848.2","29709481","Compared with the control, the Fam83h mutation altered the expression and localization of Fam83h, CK1alpha and beta-catenin in LS8 ameloblasts, inhibited mineralization and down-regulated the expression of mineralization factors."
> "Q148V8-1","RefSeq","NP_598848.2","23545224","Findings demonstrate that over-expression of FAM83H in mice does not produce a phenotype in dentine or enamel."
> "Q9JK91-1","RefSeq","NP_081086.2","29701748","Cancer preceding changes are already seen in histologically normal colon mucosa and that decreased expressions of Mlh1."
6795a9075,9078
> "Q6PDG8-1","RefSeq","NP_082645.1","24121729","Genetic interactions between Cp, Mon1a, and the Slc40a1 locus are involved in iron metabolism."
> "Q6PDG8-1","RefSeq","NP_082645.1","22665492","A role for Mon1a in anterograde trafficking through the secretory apparatus."
> "Q6PDG8-1","RefSeq","NP_082645.1","20305638","Data identify SAND-1 (Mon1) and CCZ-1 (Ccz1) as critical and evolutionarily conserved components regulating the processing of ingested apoptotic cell corpses"
> "Q6PDG8-1","RefSeq","NP_082645.1","17632513","Study presents evidence that Mon1a is involved in trafficking of ferroportin, the major mammalian iron exporter, to the surface of iron-recycling macrophages."
6802a9086,9088
> "P54310-1","RefSeq","NP_034849.2","30086728","Studied role of hormone-sensitive lipase (HSL) in adipose tissue and pancreatic inflammation, and found HSL deficiency hastens is associated with adipose tissue and pancreatic inflammation, and development of pancreatic ductal adenocarcinoma in a transgenic mouse model. Publication Status: Online-Only"
> "P54310-1","RefSeq","NP_034849.2","29232702","HSL-deficient mice revealed a complex interorgan interaction between adipose tissue and liver: the role of HSL in the liver is minimal but adipose tissue deficiency of HSL can cause age-dependent hepatic steatosis Publication Status: Online-Only"
> "P54310-1","RefSeq","NP_034849.2","28851734","Cardiac PLIN2 plays an important pathophysiological role in the development of dynamic steatosis and that the latter was prevented by upregulation of intracellular lipases, including Hormone-sensitive Lipase."
6806a9093,9096
> "Q8CHK3-1","RefSeq","NP_084210.2","30851234","LPIAT1-deficient RAW264.7 cells showed prolonged oscillations of intracellular calcium."
> "Q8CHK3-1","RefSeq","NP_084210.2","23472195","LPIAT1 has an essential role in maintaining physiological levels of PtdIns and PtdInsP(2) in the mouse"
> "Q8CHK3-1","RefSeq","NP_084210.2","23097495","Data show that lysophosphatidylinositol acyltransferase 1 (LPIAT1, also known as MBOAT7) plays a crucial role in brain development in mice."
> "Q8CHK3-1","RefSeq","NP_084210.2","21746835","Congenital hydrocephalus in Mboat 7 null mice"
6814a9105,9107
> "Q3ZN08-1","RefSeq","NP_598464.3","26026268","Results suggest that SIPAR terminates the activation of STAT3 through a dephosphorylation process that is dependent upon interaction with TC45 in the nucleus"
> "Q3ZN08-1","RefSeq","NP_598464.3","23917203","SIPAR, functioning as a new negative regulator, inhibits STAT3 activity by enhancing its dephosphorylation and represses melanoma progression."
> "Q3ZN08-1","RefSeq","NP_598464.3","19659802","The two ORFs on the Acpin1 mRNA are independently translated in differentiated cells"
6816a9110,9114
> "Q9Z0S6-1","RefSeq","NP_076367.2","29129401","Severe individual renal phenotypes in claudin-10 and claudin-16 knockout mice are corrected by the additional deletion of the other claudin."
> "Q9Z0S6-1","RefSeq","NP_076367.2","28771254","ConclusionCLDN10 mutations cause a dysfunction in TJs in several tissues and, subsequently, abnormalities in renal ion transport, ectodermal gland homeostasis, and epidermal integrity."
> "Q9Z0S6-1","RefSeq","NP_076367.2","29145406","Findings suggest that the axis IL-10/claudin-10 is a promising target for the development of therapeutic agents against aggressive melanoma Publication Status: Online-Only"
> "Q9Z0S6-1","RefSeq","NP_076367.2","26340953","Localization of Cldn3, Cldn7 and Cldn10 proteins in the different compartments of murine endometrium up to day 8.5 of pregnancy (dpc) as well as in human endometrium and first trimester decidua"
> "Q9Z0S6-1","RefSeq","NP_076367.2","14698084","Claudin-10 is expressed at the variety of epithelial tissues in the coclea of inner ear including Organ of Corti, stria vascularis, Reissner's membrane, and spiral limbus."
6829a9128,9130
> "Q9D7Q1-1","RefSeq","NP_082255.1","29891554","These data show a detrimental role of chit1 in Klebsiella pneumoniae lung infections"
> "Q9D7Q1-1","RefSeq","NP_082255.1","26079949","No significant differences were observed between experimental autoimmune encephalitis and control groups for CHIT-1 expression."
> "Q9D7Q1-1","RefSeq","NP_082255.1","23685110","CHIT1 exerts protective effects against atherosclerosis by suppressing inflammatory responses and polarizing macrophages toward an M2 phenotype, and promoting lipid uptake and cholesterol efflux in macrophages."
6836,6837d9136
< "Q99PN3-1","RefSeq","NP_001020770.2","29203640","Sustained exposure of cells to TGF-beta resulted in recovery from proliferative arrest in association with amplification of the Myc proto-oncogene, with MYC inhibiting TRIM26 induction by TGF-beta. Publication Status: Online-Only"
< "Q99PN3-1","RefSeq","NP_001020770.2","25763818","Our findings delineate a novel mechanism for the termination of IRF3 activation in nucleus through TRIM26-mediated IRF3 ubiquitination and degradation. Publication Status: Online-Only"
6839a9139,9146
> "P21237-1","RefSeq","NP_001303239.1","17149751","Distinct tissue-specific expression profiles of each of mouse 5' exon-specific transcripts in different brain regions and nonneural tissues."
> "P81117-1","RefSeq","NP_001123951.1","30503692","Findings suggested that the hypogonadotropic hypogonadism associated with obesity may be induced by reduced hypothalamic NUCB2/nesfatin-1 levels."
> "P81117-1","RefSeq","NP_001123951.1","29705701","The results demonstrate a novel role of PDK1 in AgRP neurons to counteract the high salt diet-induced hypertension by preventing hyperactivation of paraventricular nucleus nesfatin-1 neurons."
> "P81117-1","RefSeq","NP_001123951.1","28855042","NUCB2/nesfatin-1 is expressed in mouse placenta. Significant expression of NUCB2 in primary trophoblast cells during syncytialisation."
> "P81117-1","RefSeq","NP_001123951.1","28697955","Because Kv channel inhibition enhances insulin secretion under high glucose conditions, our present data suggest a possible mechanism of nesfatin-1 on enhancing glucose-stimulated insulin secretion through regulation of ion channels rather than its unidentified receptor."
> "P81117-1","RefSeq","NP_001123951.1","28339602","Nesfatin-1 acts directly on hypothalamic neurons and gonadotropes to elicit a generally positive influence on the endocrine milieu regulating reproduction in mice. Reproductive hormones, in turn, modulate brain and pituitary NUCB2/nesfatin-1. Erratum:[Biol Reprod. 2017 May 1;96(5):1118. PMID: 28863435]"
> "P81117-1","RefSeq","NP_001123951.1","19248766","These results indicate that the insulin producing beta cells colocalize pronesfatin in the islets of both mice and rats."
> "P81117-1","RefSeq","NP_001123951.1","18477467","5-HT systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors, and induce anorexia via a leptin-independent pathway in mice."
6845a9153,9154
> "Q8C165-1","RefSeq","NP_835180.2","29967167","These data demonstrate that PM20D1 is a dominant enzymatic regulator of NAA levels in vivo and elucidate physiologic functions for NAA signaling in metabolism and nociception."
> "Q8C165-1","RefSeq","NP_835180.2","27374330","Study demonstrates that PM20D1 is a bidirectional enzyme in vitro, catalyzing both the condensation of fatty acids and amino acids to generate N-acyl amino acids and also the reverse hydrolytic reaction. N-acyl amino acids directly bind mitochondria and function as endogenous uncouplers of UCP1-independent respiration."
6854,6855d9162
< "Q9JLN6-1","RefSeq","NP_034212.1","28707394","The results suggest that CD19 controls the differentiation of marginal zone precursors to marginal zone B cells by regulating ADAM28-mediated Notch2 cleavage."
< "Q9JLN6-1","RefSeq","NP_034212.1","11724793","The authors report that recombinant human MDC-L (ADAM 28) protein with the disintegrin domain binds to the alpha(4)beta(1) integrin, and this binding may regulate the interaction between lymphocytes and leukocytes expressing alpha(4)beta(1)."
6881a9189,9191
> "Q5SV06-1","RefSeq","NP_001038996.1","28453612","We find that MEIOB and SPATA22 form an obligate complex and contain defined interaction domains"
> "Q5SV06-1","RefSeq","NP_001038996.1","28297563","Together, these data suggest that SPATA22 is required for both meiotic recombination and synapsis during meiosis in mice."
> "Q5SV06-1","RefSeq","NP_001038996.1","22011390","Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells. Publication Status: Online-Only"
6889,6892d9198
< "Q99MU3-1","RefSeq","NP_001139768.1","30651342","The results reveal an unrecognized role of ADAR1 in DC subset homeostasis and unveils the cell type-specific effects of RNA editing."
< "Q99MU3-1","RefSeq","NP_001139768.1","30669342","ADAR1p150 plays a key role in complexing with Dicer and promoting the expression of miRNA-222, the latter of which suppresses the expression of the target gene PTEN during VMC. Our work reveals a previously unknown role of ADAR1p150 in gene expression in VMC. Publication Status: Online-Only"
< "Q99MU3-1","RefSeq","NP_001139768.1","30559380","ADAR1 functions as a checkpoint that limits anti-tumour immunity by preventing the sensing of endogenous dsRNA. Loss of function of ADAR1 improves responses to PD-1 blockade and overcomes common mechanisms of resistance to immunotherapy."
< "Q99MU3-1","RefSeq","NP_001139768.1","28960389","ADAR1 functions other than RNA editing are reviewed. Review article"
6900a9207,9213
> "Q61069-1","RefSeq","NP_033506.1","30545366","Our findings identify USF1 as a novel factor regulating HDL functionality, showing that USF1 inactivation boosts cholesterol efflux, reduces macrophage inflammation and attenuates macrophage cholesterol accumulation, linking improved macrophage cholesterol metabolism and inflammatory pathways to the antiatherogenic function of USF1 deficiency. Publication Status: Online-Only"
> "Q61069-1","RefSeq","NP_033506.1","30214629","The authors found that USF1 induced miR-125a-3p levels which suppressed Chi3L1 expression. Their results suggest that lung metastasis is suppressed by knock-down of Chi3L1 through miR-125a-3p-mediated up-regulation of USF1. Publication Status: Online-Only"
> "Q61069-1","RefSeq","NP_033506.1","29871931","ILEI contributes to melanoma cell invasiveness in vivo without affecting primary tumor growth and is transcriptionally up-regulated by USF-1."
> "Q61069-1","RefSeq","NP_033506.1","26819196","Mice lacking Usf1 displayed increased BAT-facilitated, diet-induced thermogenesis with up-regulation of mitochondrial respiratory chain complexes, as well as increased BAT activity even at thermoneutrality and after BAT sympathectomy"
> "Q9Z2H2-1","RefSeq","NP_056627.1","29079565","RGS6 and oxidized CaMKIIdelta together function as novel critical upstream modulators of Notch signaling required for normal cardiovascular development and embryo survival. Publication Status: Online-Only"
> "Q9Z2H2-1","RefSeq","NP_056627.1","27713144","Data show that RGS6 loss impairs p53 activation and promotes aberrant accumulation of oncogenic protein DNMT1 in urothelium."
> "Q9Z2H2-1","RefSeq","NP_056627.1","20616094","Rgs16 and Rgs8 are likely to control aspects of islet progenitor cell activation, differentiation and beta-cell expansion in embryos and metabolically stressed adults."
6905,6907c9218,9222
< "B1AXP6-1","RefSeq","NP_001093145.1","22688586","Spontaneous development of cryptogenic organizing (intra-alveolar fibrosis) pneumonia in Tomm5-/- mice."
< "Q80TJ1-1","RefSeq","NP_001036082.1","28883501","Together, these data show that the CAPS-1 C-terminus regulates synaptic enrichment of CAPS-1. All CAPS-1 functional domains are required, and the C2 and PH domain together are not sufficient, for dense core vesicles exocytosis in mammalian central nervous system neurons. Publication Status: Online-Only"
< "Q80TJ1-1","RefSeq","NP_001036082.1","16506193","The two CAPS family proteins are complementarily distributed throughout the various brain regions of mice."
---
> "B7ZC55-1","RefSeq","NP_001157093.1","30423386","High APOL6 expression is associated with obesity and obesity-related cancers."
> "Q91W27-1","RefSeq","NP_444486.1","28454729","TIP39-PTH2R system appears to be a previously unrecognized mechanism for regulation of extracellular matrix formation and wound repair."
> "Q91W27-1","RefSeq","NP_444486.1","26338326","This study demonstrated that TIP39 signaling plays a role in fear incubation and suggest that may serve to ameliorate the long-term negative outcome of traumatic experience via PTH2R-expressing neurons in the Medial Nucleus of the Amygdala."
> "Q91W27-1","RefSeq","NP_444486.1","23878240","Data indicate that the nociceptive phenotype of TIP39-knockout {KO) mice was similar to the PTH2R-KO."
> "Q91W27-1","RefSeq","NP_444486.1","12084532","PTH1 receptor antagonism"
6925a9241,9246
> "Q61712-1","RefSeq","NP_031895.1","22837305","Data suggest that vaspin is a ligand for cell-surface GRP78 (glucose-regulated protein 78kD)/MTJ-1 complex; subsequent signal transduction exerts beneficial effects on endoplasmic reticulum stress-induced metabolic dysfunctions as seen in obesity."
> "Q61712-1","RefSeq","NP_031895.1","18213612","Plasma membrane-associated GRP78 is coupled to pertussis toxin-insensitive Galphaq11 and forms a ternary signaling complex with MTJ-1"
> "Q61712-1","RefSeq","NP_031895.1","16271702","ITIH4 and MTJ1 co-immunoprecipitate from total liver protein extracts and SANT domain of HTJ1 protects the ITIH4(588-930) recombinant fragment"
> "Q61712-1","RefSeq","NP_031895.1","16244664","ERj1p inhibits translation in the absence of BiP, and mediates binding of the nuclear import factor importin beta and import into the nucleus."
> "Q61712-1","RefSeq","NP_031895.1","16244660","ERj1p coordinates the ribosome at the membrane and allosteric effects may mediate ERj1p's regulatory activity"
> "Q61712-1","RefSeq","NP_031895.1","15699139","In addition to assisting the chaperone GRP78 in protein quality control in the endoplasmic reticulum, MTJ-1 is essential for transport of GRP78 to the macrophage surface, which serves a number of functions in immune regulation and signal transduction."
6935a9257,9258
> "Q9CYH2-1","RefSeq","NP_081740.2","26438880","Results suggest that adipocyte-derived PAMM may suppress macrophage activation by inhibiting MAPK signalling pathway."
> "Q9CYH2-1","RefSeq","NP_081740.2","19951071","The PAMM is a redox regulatory protein that modulates osteoclast differentiation in vitro. PAMM expression may affect bone resorption in vivo and help to maintain bone mass."
6939c9262
< "P63015-1","RefSeq","NP_001231130.1","16464444","Pax6 expression, analyzed using a BAC transgene, revealed the presence of a paired-less isoform in the eye and olfactory bulb."
---
> "Q920S1-1","RefSeq","NP_694692.1","15269100","Gzmn is not involved in the process of germ cell apoptosis induced by heat shock, but it may be involved in spermatogenesis in the mouse testes."
6942a9266,9267
> "P19973-1","RefSeq","NP_062264.1","27555448","Regulation of O-GlcNAcylation and phosphorylation of lymphocyte-specific protein-1 (Lsp1) is a key switch that triggers apoptosis in activated B cells. O-GlcNAcylation at S209 of Lsp1 is a prerequisite for the recruitment of its kinase, PKC-beta1, to induce S243 phosphorylation. Publication Status: Online-Only"
> "P19973-1","RefSeq","NP_062264.1","26554018","The importance of LSP1 Copy number variations and LSP1 insufficiency in the pathogenesis of rheumatoid arthritis, is reported."
6948a9274,9277
> "O70337-1","RefSeq","NP_031572.1","28986568","Bcl-2 interacting killer (Bik) decreases airway epithelial hyperplasia via apoptosis mediated by calcium release from the endoplasmic reticulum (ER), but the mechanism is unclear. Here the authors show that Bik promotes Bak enrichment at the ER to tether mitochondria for efficient calcium transfer. Publication Status: Online-Only"
> "O70337-1","RefSeq","NP_031572.1","27262843","OPN induces oxidative stress via the involvement of mitochondria and NOX-4. It may affect mitochondrial morphology and integrity, at least in part, via the involvement of BIK."
> "O70337-1","RefSeq","NP_031572.1","26437021","These studies suggest a link between Bik-mediated caspase activation and cleavage of viral proteins."
> "O70337-1","RefSeq","NP_031572.1","11714762","Blk has been mapped to chromosome 15 and overexpressed in transitional B cells of A/WySnJ mice, which demonstrate a cell-autonomous defect leading to excessive apoptosis."
6953a9283,9288
> "P59113-1","RefSeq","NP_932146.2","29330144","Kindin-1 is a critical mediator of early lung metastasis of breast cancer."
> "P59113-1","RefSeq","NP_932146.2","28954813","Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin."
> "P59113-1","RefSeq","NP_932146.2","28501563","Loss of Kindlin-1 leads to an imbalance in the cellular oxidative state, which renders Kindlin-1 deficient cells more prone to the effects of reactive oxygen species generated in response to oxidative stress"
> "P59113-1","RefSeq","NP_932146.2","19240021","Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects"
> "P59113-1","RefSeq","NP_932146.2","19057668","Kindlin-1 in mice gives rise to skin atrophy and an intestinal epithelial dysfunction with similarities to human ulcerative colitis."
> "P59113-1","RefSeq","NP_932146.2","16876785","The genomic organization, gene expression and subcellular localization of murine Kindlins-1 to -3, is described."
6963a9299
> "Q148V7-1","RefSeq","NP_775279.2","29514919","These data suggest that RELCH promotes nonvesicular cholesterol transport from recycling endosomes to the trans-Golgi network through membrane tethering."
6969a9306,9307
> "Q9JLL3-1","RefSeq","NP_038897.4","29237753","Data show that Troy marks a renal stem/progenitor cell population in the developing kidney that in adult kidney contributes to homeostasis, predominantly of the collecting duct, and regeneration."
> "E9PVD1-1","RefSeq","NP_001128239.1","28339613","Required for maintenance for normal spermiogenesis and male fertility"
6976d9313
< "Q8K214-1","RefSeq","NP_001153102.1","23207902","Loss of Scmh1 caused derepression of Hoxb4 and Hoxa9, direct targets of Polycomb-group complex 1-mediated transcriptional silencing in hematopoietic cells."
6982a9320
> "Q924W7-1","RefSeq","NP_084087.2","29650351","ST5 overexpression has no mitogenic effect on the adult beta-cell under basal and metabolically challenged states."
6991,6993c9329,9331
< "Q8VE91-4","RefSeq","NP_001030023.1","27511895","FAM134B-dependent endoplasmic reticulum (ER)-phagy is an important limiting event in Ebola virus (EBOV) replication in mouse cells"
< "Q8VE91-4","RefSeq","NP_001030023.1","26040720","Selective endoplasmic reticulum (ER)-phagy via FAM134 proteins is indispensable for mammalian cell homeostasis and controls ER morphology and turnover in mice and humans"
< "Q8VE91-4","RefSeq","NP_001030023.1","19838196","Show that loss-of-function mutations in FAM134B, encoding a newly identified cis-Golgi protein, cause hereditary sensory and autonomic neuropathy type II."
---
> "Q60928-1","RefSeq","NP_032142.1","30591459","GGsTop is a newly-discovered gamma-glutamyl transpeptidase (GGT) inhibitor...GGsTop treated Oral mucositis (OM) quickly and safely. GGsTop is highly valuable for use as a treatment for OM"
> "Q60928-1","RefSeq","NP_032142.1","28660214","The present study developed a liver-specific GGT-overexpressing mice model and found that GGT elevation in short term had no effects on glucose metabolism but could increase insulin sensitivity through enhancing the activity of insulin signaling pathway."
> "Q60928-1","RefSeq","NP_032142.1","27775020","These findings elucidate a novel mechanism of inflammation-associated osteoclastogenesis, which involves TLR4 recognition of gamma-glutamyltranspeptidase and subsequent activation of MyD88-dependent signaling. Publication Status: Online-Only"
7012a9351,9352
> "Q9ERD8-1","RefSeq","NP_071716.3","16479001","Despite the high expression of gamma-parvin in hematopoietic cells it must play a more subtle role for blood cell homeostasis"
> "Q9ERD8-1","RefSeq","NP_071716.3","11722847","Mammalian parvins are likely to have arisen late in evolution from gene duplication as they share a remarkably similar exon/intron organization."
7019c9359
< "P46737-1","RefSeq","NP_001159929.1","23246432","The deubiquitinating enzyme, BRCC3, is a critical regulator of NLRP3 activity by promoting its deubiquitination."
---
> "Q6NXH3-1","RefSeq","NP_082763.3","14612417","Binds specifically to the adenosine deaminase gene promoter"
7021,7023c9361,9369
< "Q9EQZ6-1","RefSeq","NP_001191094.1","30252533","Deletion of Epac1 and Epac2 decreases sodium-hydrogen exchanger type 3 expression in the proximal tubule, leading to polyuria and osmotic diuresis"
< "Q9EQZ6-1","RefSeq","NP_001191094.1","30048476","Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice Publication Status: Online-Only"
< "Q9EQZ6-1","RefSeq","NP_001191094.1","12401793","Piccolo serves as a Ca(2+) sensor in exocytosis in pancreatic beta-cells and the formation of a cAMP-GEFII.Rim2.Piccolo complex is important in cAMP-induced insulin secretion"
---
> "P84075-1","RefSeq","NP_034601.1","30091036","Neurogenic markers, including doublecortin and the neuronal nuclei antigen, and hippocalcin, otub1, and spectrin-alpha are potential molecular links between hippocampal neurogenesis and exercise in the elderly."
> "P84075-1","RefSeq","NP_034601.1","25752619","Results suggest that 7,8-Dihydroxy-4-methylcoumarin prevents glutamate-induced toxicity by scavenging free radicals and regulating hippocalcin expression."
> "P84075-1","RefSeq","NP_034601.1","23260046","Hippocalcin and KCNQ channels contribute to the kinetics of the slow afterhyperpolarization"
> "P84075-1","RefSeq","NP_034601.1","15607944","An age-dependent increase in neurodegeneration occurred in the gene-deleted mice, showing that hippocalcin contributes to neuronal viability during aging."
> "Q64448-1","RefSeq","NP_058671.2","26017495","That expression and phosphorylation of connexin 46 and connexin 45 are complementary in seminiferous tubules Erratum:[Am J Physiol Regul Integr Comp Physiol. 2015 Dec 15;309(12):R1578. PMID: 26671929]"
> "Q64448-1","RefSeq","NP_058671.2","25740157","The localization and sizes of Cx50 gap junction plaques in DKO fibers were unaffected, suggesting that Cx46 and Cx50 form homomeric channels"
> "Q64448-1","RefSeq","NP_058671.2","25294879","Data indicate that connexin 46 (cx46) is essential for the maintenance of adequate levels of glutathione (GSH) in the lens nucleus."
> "Q8CH20-1","RefSeq","NP_080014.2","17342728","Human VCX/Y, SPANX, and CSAG2 gene families together with the murine SPANX gene and the CYPT family may share a common ancestor."
> "Q8CH20-1","RefSeq","NP_080014.2","15286030","CYPT1 and the proteins of the paralogous genes constitute a novel, basic cysteine-rich sperm protein family that may contribute to the function of the postacrosomal PT during nuclear shaping."
7025a9372,9374
> "Q4LDD4-1","RefSeq","NP_932764.1","29589748","Competitive analytical gel-filtration chromatography and isothermal titration calorimetry (ITC) results showed that ARAP1 could compete with Cbl for CIN85 binding, which provides a biochemical basis for the regulatory roles of ARAP1 in the CIN85-mediated EGFR internalizing process."
> "Q4LDD4-1","RefSeq","NP_932764.1","28132686","Quantitative trait loci genes analysis reveals association between T2D risk variants at the ARAP1/STARD10 locus and STARD10 but not ARAP1 expression."
> "Q4LDD4-1","RefSeq","NP_932764.1","19589776","Afadin regulates the cyclical activation and inactivation of Rap1, Rac1, and RhoA through SPA-1 and ARAP1."
7030a9380,9385
> "P56818-1","RefSeq","NP_035922.4","31014193","That NEAT1 worked as a regulating factor to promote the development of AD via modulating miR-124/BACE1 axis"
> "P56818-1","RefSeq","NP_035922.4","30701309","The results of this study suggest that BACE1 is important for normal dentate gyrus network function."
> "P56818-1","RefSeq","NP_035922.4","30837353","Concomitant gene silencing of BACE1, and consequent reduction in plaque load in the cerebral cortex and hippocampus (greater than 60%) in mice treated with TARBP-BTP:siRNA complex, led to improvement in spatial learning and memory."
> "Q64373-1","RefSeq","NP_033873.3","29704100","Depletion of miR-34a facilitated endothelial cell growth and blocked apoptosis in AS by upregulating Bcl-2, offering a promising avenue for AS therapy."
> "Q64373-1","RefSeq","NP_033873.3","30261081","Examined the roles of BCL2 proteins in the induction of apoptosis in cells upon infection with flaviviruses, such as Japanese encephalitis virus, Dengue virus and Zika virus. Showed that survival of the infected cells depends on BCLXL, a pro-survival BCL2 protein due to suppression of the expression of another pro-survival protein, MCL1. Publication Status: Online-Only"
> "Q64373-1","RefSeq","NP_033873.3","30154103","Data indicate a role for ROR-gamma (RORgammat) and Bcl-XL protein (Bcl-xL) in limiting interleukin 2 receptor gamma chain (gammac) abundance at the cell surface. Publication Status: Online-Only"
7036a9392,9396
> "P49182-1","RefSeq","NP_032249.3","30870413","Trancriptomic analysis shows that expression of the antithrombins serpin C1 and D1 is significantly reduced in Schwann cell-deficient mice. In the absence of peripheral neuromuscular activity, neurodegeneration is completely blocked, and expression of prothrombin in muscle is markedly reduced. Publication Status: Online-Only"
> "P49182-1","RefSeq","NP_032249.3","28502917","Loss of Heparin Cofactor is associated with insulin resistance ."
> "P49182-1","RefSeq","NP_032249.3","23656734","In this study, we demonstrate a previously unknown role for HCII in host defense"
> "P30115-1","RefSeq","NP_034486.2","29804515","Aflatoxin B1 induces cholangiocarcinomas in GSTA3-/- mice"
> "P30115-1","RefSeq","NP_034486.2","28535182","There were no significant compensatory changes in KO mice GST subunits, GST enzymatic activity, epoxide hydrolase, or CYP1A2 and CYP3A11 levels. Finally, there was a modest increase in F2-isoprostane and isofuran in KO mice that confirmed putative GSTA3 hydroperoxidase activity in vivo for the first time."
7050a9411,9415
> "Q62172-1","RefSeq","NP_033093.2","29572430","Rlip deficiency suppresses spontaneous malignancy in p53(-/-) mice."
> "Q62172-1","RefSeq","NP_033093.2","26498519","RLIP76 acts as a scaffold at recycling endosomes by binding activated R-Ras, recruiting ARNO to activate Arf6, thereby contributing to cell spreading and migration."
> "Q62172-1","RefSeq","NP_033093.2","25450693","The results show that ARNO interaction with the RLIP76 N-terminus regulates cell spreading and motility via PI3K and Arf6, independent of RLIP76 control of Rac."
> "Q62172-1","RefSeq","NP_033093.2","24188744","The expression of Hsf4b known to be involved in lens development is down regulated in the lens of these Tg mice."
> "Q62172-1","RefSeq","NP_033093.2","23821548","A fundamental role of RLIP76 in regulating the function of obesity-promoting pro-inflammatory cytokines"
7052a9418
> "Q6P073-1","RefSeq","NP_067377.4","19951915","Ube2j2 is the primary cellular E2 recruited by the mK3 ligase, and this E2-E3 pair is capable of conjugating Ub on lysine or serine residues of substrates."
7061,7062d9426
< "Q99KW3-3","RefSeq","NP_001034245.1","28209736","Missense mutations in the Pejvakin (PJVK or DFNB59) gene were first identified in patients with audiological hallmarks of auditory neuropathy spectrum disorder, whereas all other PJVK alleles cause hearing loss of cochlear origin. These findings suggest that complex pathogenetic mechanisms underlie human deafness DFNB59."
< "Q99KW3-3","RefSeq","NP_001034245.1","23789641","R1 motif is the major actin-binding domain of TRIOBP-4, and the binding of R2 motif with actin filaments is nonspecific."
7063a9428,9434
> "O70318-1","RefSeq","NP_038539.2","28755316","The 4.1G functions as a signal for proper formation of myelin in peripheral nervous system."
> "O70318-1","RefSeq","NP_038539.2","26644476","4.1G has a role in cell adhesion, spreading, and migration in MEF cells by modulating the surface expression of beta1 integrin and subsequent downstream signal transduction"
> "Q8BG16-1","RefSeq","NP_780537.1","28576941","Our study demonstrates a role for reduced Slc6a15, a neutral amino acid transporter, in nucleus accumbens (NAc) in depression and stress susceptibility. The reduction of Slc6a15 occurs selectively in the NAc D2-neurons. Genetic reduction of Slc6a15 induces susceptibility to a subthreshold stress, while genetic overexpression in D2-neurons prevents social avoidance after chronic social defeat stress."
> "Q8BG16-1","RefSeq","NP_780537.1","26585320","Slc6a15 plays a role in modulating emotional behavior, possibly mediated by its impact on glutamatergic neurotransmission."
> "Q8BG16-1","RefSeq","NP_780537.1","26228428","SLC6A15 regulates the activity of the brain glutamatergic system through the proline-glutamate biosynthesis pathway, affecting hippocampal neurochemistry and consequently behavior."
> "Q8BG16-1","RefSeq","NP_780537.1","17931606","Slc6a15 knockout mice demonstrate only modest alterations in rotarod performance with aging and lack reproducible alterations in other motor, memory, anxiety or olfactory tests"
> "Q8BG16-1","RefSeq","NP_780537.1","16185194","The structure and function of B0AT2 are reported."
7075,7078c9446,9453
< "Q924A2-4","RefSeq","NP_001289740.1","31043608","These results identify Cic as an important regulator of cell fate in neurodevelopment and oligodendroglioma, and suggest that its loss contributes to oligodendroglioma by promoting proliferation and an oligodendrocyte precursor cells -like identity via Ets overactivity. Publication Status: Online-Only"
< "Q924A2-4","RefSeq","NP_001289740.1","29844126","CIC is a transcriptional repressor of genes regulated by MAPK signaling."
< "Q924A2-4","RefSeq","NP_001289740.1","29382756","Loss of CIC causes T cell lymphoblastic leukemia/lymphoma."
< "Q924A2-4","RefSeq","NP_001289740.1","12393275","Results describe the identification and characterization of a new gene, Cic, in both human and mouse genomes, that is implicated in granule cell development."
---
> "Q8BHJ9-1","RefSeq","NP_945174.1","29870742","Knockdown of hepatic Slu7 by adenovirus-Slu7shRNA treatment ameliorated inflammation and attenuated liver injury in mice after ethanol administration."
> "Q8BHJ9-1","RefSeq","NP_945174.1","24865429","SLU7 knockdown in liver resulted in profound changes in pre-mRNA splicing and gene expression, leading to impaired glucose and lipid metabolism, refractoriness to key metabolic hormones, and reversion to a fetal-like gene expression pattern."
> "Q8VC19-1","RefSeq","NP_065584.2","24821812","RNAi-mediated silencing of hepatic Alas1 effectively prevents and treats the induced acute attacks in acute intermittent porphyria mice."
> "Q8VC19-1","RefSeq","NP_065584.2","22070747","Both ALAS1 mRNA and protein content were induced in diabetic animals, accompanied by decreased Akt phosphorylation and increased nuclear FOXO1, PGC-1alpha and FOXO1-PGC-1alpha complex levels."
> "Q8VC19-1","RefSeq","NP_065584.2","21600186","Active site functional asymmetry extends to chimeric ALAS/AONS proteins, which while having a different oligomeric state, exhibit different rates of product release from the two ALAS and two AONS active sites due to the created intermolecular strain"
> "Q8VC19-1","RefSeq","NP_065584.2","21044876","Egr-1 regulates the transcriptional repression of mouse delta-aminolevulinic acid synthase 1 by heme"
> "Q8VC19-1","RefSeq","NP_065584.2","20015225","Mice bearing a homozygous knock-in allele were lethal by embryonic day 8.5, demonstrating that ALAS-N is essential for early embryogenesis."
> "Q8VC19-1","RefSeq","NP_065584.2","12881517","Identified a drug-responsive enhancer in the ALAS1 gene"
7081a9457,9464
> "Q8BP22-1","RefSeq","NP_080834.3","17557235","Protein expression, expressing profile and subcellular localization of AK078438 gene set the basis for further exploration of its functions.[AK078438]"
> "B1AXP6-1","RefSeq","NP_001128118.1","22688586","Spontaneous development of cryptogenic organizing (intra-alveolar fibrosis) pneumonia in Tomm5-/- mice."
> "Q925T6-1","RefSeq","NP_597699.1","29170386","GRIP1 is phosphorylated at an N-terminal serine cluster by cyclin-dependent kinase-9 (CDK9), which is recruited into GC-induced GR:GRIP1:CDK9 hetero-complexes, producing distinct GRE-specific GRIP1 phospho-isoforms. Publication Status: Online-Only"
> "Q925T6-1","RefSeq","NP_597699.1","28978486","GRIP1 binds to apoER2 and EphrinB2 to induce activity-dependent AMPA receptor insertion at the synapse."
> "Q925T6-1","RefSeq","NP_597699.1","28063882","Study performed social behavioral testing on neuron-specific Grip1/2-double knockout (DKO) and wild type (WT) mice and determined the expression profile of key signaling proteins in AMPAR, mGluR, mTOR, and GABA pathways in brain. Data Grip1/2-mediated AMPA signaling in regulating social behaviors and disturbance of glutamate- and GABA-signaling in specialized brain regions in autism-related social behavioral deficits."
> "Q925T6-1","RefSeq","NP_597699.1","27941904","Data suggest that molecules in the erythropoietin-producing hepatocellular receptor B family (EPHB) / ephrinB (EFNB) signalling pathways, specifically ephrin B3 and GRIP1, are involved blood pressure regulation. Publication Status: Online-Only"
> "Q925T6-1","RefSeq","NP_597699.1","15507123","Investigated whether there is a link between growth inhibitory effect and transcriptional activation of PPARgamma in several gastrointestinal tumour cell lines [GRIP1tau]"
> "Q925T6-1","RefSeq","NP_597699.1","11983858","GRIP1 scaffolding protein is required for the formation and integrity of the dermo-epidermal junction and reveal the importance of PDZ domains in the organization of supramolecular structures essential for mammalian embryonic development."
7085a9469,9471
> "Q9CRB3-1","RefSeq","NP_084097.1","20823251","Substitution of cysteine for tyrosine in a conserved helical region of HIU hydrolase resulted in undetectable protein expression. Homozygotes for the mutation had elevated platelet counts secondary to excess thrombopoietin production and hepatomegaly."
> "Q9CRB3-1","RefSeq","NP_084097.1","17085964","Study provides evidence that mouse transthyretin-related protein facilitates the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction."
> "Q9CRB3-1","RefSeq","NP_084097.1","16462750","Identified as the gene encoding the enzyme catalyzing the second step of the pathway from uric acid to S-allantoin."
7093a9480,9483
> "Q9WTZ1-1","RefSeq","NP_035409.1","30574150","Study in transgenic mice with selective Sag deletion in myeloid lineage found that in contrast to in vitro observations those mice showed increased serum levels of proinflammatory cytokines and enhanced mortality in response to LPS. Sag-/- macrophages released less proinflammatory cytokines, neutrophils released more. Study revealed that Sag plays a differential role in the activation of macrophages and neutrophils. Publication Status: Online-Only"
> "Q9WTZ1-1","RefSeq","NP_035409.1","30269386","In the brain, Cul5 and Rbx2 are expressed in a similar fashion"
> "Q9WTZ1-1","RefSeq","NP_035409.1","29361558","RBX2, a core component of the E3 ubiquitin ligase CRL5, is essential for retinal layering and function. RBX2 regulates the final cell position of rod bipolar cells, cone photoreceptors and Muller glia. Our data indicate that sustained RELN/DAB1 signaling, triggered by depletion of RBX2 or SOCS7 - a CRL5 substrate adaptor known to recruit DAB1 - causes rod bipolar cell misposition. Publication Status: Online-Only"
> "Q9WTZ1-1","RefSeq","NP_035409.1","27543965","SAG is a novel molecular target that regulates T-cell responses and that inhibiting neddylation with the clinically available small-molecule MLN4924 may represent a novel strategy to mitigate T-cell-mediated immunopathologies, such as graft-versus-host disease."
7100a9491,9494
> "Q91V51-1","RefSeq","NP_849200.2","29593216","Klf4 polyglutamylation plays a critical role in the regulation of cell reprogramming and pluripotency maintenance in a process that involves TTLL4 and TTLL1 Publication Status: Online-Only"
> "Q91V51-1","RefSeq","NP_849200.2","20442420","TTLL1 plays a role in establishing normal functions of specific cilia and flagella."
> "Q91V51-1","RefSeq","NP_849200.2","20498047","Loss of beating asymmetry resulted in a reduction of cilia-generated fluid flow in trachea from the Ttll1 knock-out mice."
> "Q91V51-1","RefSeq","NP_849200.2","15890843","Findings showed that the neuronal tubulin polyglutamylase is a protein complex containing a tubulin tyrosine ligase-like (TTLL) protein, TTLL1"
7104a9499,9501
> "O88522-1","RefSeq","NP_034677.2","30295325","It up-regulates NF kappa-B and involves in inflammation pathway."
> "O88522-1","RefSeq","NP_034677.2","30476545","Gene array analyses revealed up-regulated stress response and metabolism pathways in hepatocytes from NEMO(LPC-knockout)Cxcr6(-/-) mice."
> "O88522-1","RefSeq","NP_034677.2","29551768","High NEMO expression is associated with hepatitis and hepatocarcinogenesis."
7108a9506,9510
> "Q6NS52-1","RefSeq","NP_848796.2","27495014","Memantine, an NMDA receptor antagonist, improves working memory deficits in Diacylglycerol kinase (DGK) beta knockout mice. These findings may support the hypothesis that DGKbeta has a pivotal role in cognitive function."
> "Q6NS52-1","RefSeq","NP_848796.2","25446448","These findings suggest that DGKbeta regulates the spine formation at distal dendrites in medium spiny neurons"
> "Q6NS52-1","RefSeq","NP_848796.2","23503970","This study demonistrated that Dgkb distribuate in mice cerebellum"
> "Q6NS52-1","RefSeq","NP_848796.2","23814057","Forced expression of diacylglycerol kinase beta abrogated DAG accumulation at the phagosome, leading to impaired respiratory burst. Erratum:[J Biol Chem. 2014 Feb 21;289(8):4813. Chatilialoglu, Alexandros [corrected to Chatgilialoglu, Alexandros]]"
> "Q6NS52-1","RefSeq","NP_848796.2","20657643","Results demonstrate that membrane-localized DGKbeta regulates spine formation by regulation of lipids, contributing to the maintenance of neural networks in synaptic transmission of cognitive processes including memory. Publication Status: Online-Only"
7110a9513,9515
> "O54794-1","RefSeq","NP_031499.1","29890131","AQP7 and GLUT1 mRNA and protein have a higher expression in T1DM mice, but the levels of AQP9 mRNA and protein are not changed in the lung difference between normal and T1DM mice. T1DM may increase the expression of transporters of trivalent inorganic arsenic."
> "O54794-1","RefSeq","NP_031499.1","27746040","AQP-7 and -9 showed differential staining pattern in different stages of mouse estrus cycle. AQP-7 and -9-mediated glycerol transport in tanycyte cells might be under hormonal control to use glycerol as a potential energy substrate during mouse estrus cycle."
> "O54794-1","RefSeq","NP_031499.1","26634435","Upregulation of AQP7 plays an important role in improving of tolerance to hyperosmotic stress and survival of oocytes during cryopreservation by vitrification. Publication Status: Online-Only"
7114,7115d9518
< "Q8CBQ5-1","RefSeq","NP_080227.2","16949365","UV irradiation increases nuclear PtdIns5P levels via inhibition of the activity of the beta isoform of PtdIns5P 4-kinase (PIP4Kbeta), an enzyme that can phosphorylate and remove PtdIns5P."
< "Q8CBQ5-1","RefSeq","NP_080227.2","12011096","PI 4-kinase functions to negatively regulate GLUT4 translocation through its interaction with NCS-1."
7118a9522,9523
> "Q9JJV9-1","RefSeq","NP_067519.2","30194875","Deletion of Nav1.5 from astrocytes leads to significantly worsened clinical outcomes in experimental autoimmune encephalomyelitis (EAE), with increased inflammatory infiltrate in both early and late stages of disease in a sex-specific manner. Removal of Nav1.5 in astrocytes leads to increased inflammation in female mice with EAE, including increased astroglial response and infiltration of T cells and phagocytic monocytes."
> "Q9JJV9-1","RefSeq","NP_067519.2","11972032","Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a"
7125,7127d9529
< "P15209-1","RefSeq","NP_001020245.1","30747207","Compared with trkB.T1 wild type (WT) mice, the differentially expressed genes (DEGs) in trkB.T1 KO mice following spinal cord injury at different time points were screened out. The significant DEGs were subjected to function, coexpression and proteinprotein interaction (PPI) network analyses. Construction of a Venn diagram revealed the overlap of several DEGs in trkB.T1 KO mice under different conditions."
< "O35618-1","RefSeq","NP_001289732.1","30012555","Selective dysregulation of Mdm2 and Mdm4 alternative splicing underlies p53 anti-repression and motor neuron death in a mouse model of spinal muscular atrophy."
< "O35618-1","RefSeq","NP_001289732.1","24013503","Identify Mdm4 as one of these key mRNAs that senses the defects in the spliceosomal machinery and transduces the signal to activate the p53 response"
7145a9548,9551
> "Q64505-1","RefSeq","NP_031850.2","29243851","Vitamin D-deficiency resulted in down-regulation of liver Cyp7a1 and renal Oat3, conditions that are alleviated upon replenishment of cholecalciferol."
> "Q64505-1","RefSeq","NP_031850.2","28843503","Hypercholesterolemia in TALLYHO/jng mice might increase the Bile acids amounts via the interrupted Fxr/Fgf15/Fgfr4-mediated feedback regulation of Cyp7a1."
> "Q64505-1","RefSeq","NP_031850.2","28039331","Although feeding LS-Xbp1(-/-) mice cholesterol did not increase CYP7A1 expression, serum C4 levels increased significantly up to levels similar to chow-fed Xbp1(fl/fl) mice and the total bile acid pool normalized. In conclusion, loss of hepatic XBP1 decreased the bile acid pool and CYP7A1 synthetic activity."
> "Q64505-1","RefSeq","NP_031850.2","27534992","Current studies suggest that increased Cyp7a1 expression and bile acid synthesis ameliorate hepatic inflammation through activation of FXR"
7148a9555,9557
> "O35103-1","RefSeq","NP_036180.1","18496725","OSAD overexpression enhanced the differentiation and maturation of osteoblasts in vitro."
> "O35103-1","RefSeq","NP_036180.1","16970923","Found transforming growth factor beta1 to down regulate OSAD, while bone morphogenetic protein 2 up regulates OSAD"
> "Q8BGF6-1","RefSeq","NP_848851.3","28324667","Elmod2 is the GTPase-activating protein essential to meiosis progression of mouse oocytes, most likely by regulating mitochondrial dynamics."
7161a9571,9572
> "Q8BJ66-1","RefSeq","NP_849260.2","15555553","These results suggest that IGFBP-rP10 is involved in the proliferation of osteoblasts during bone formation and bone regeneration."
> "Q8BJ66-1","RefSeq","NP_849260.2","15261838","Expression of Bono1 was detected in osteoblasts and secretory odontoblasts by in situ hybridization."
7183a9595
> "Q497L9-1","RefSeq","NP_001032838.1","27811987","The role of Slc22a14 found that Slc22a14-deficient male mice showed severe infertility. Although the differentiation process in testis appeared to be normal, cauda epididymal spermatozoa in Slc22a14-/- mice showed impaired motility with abnormal tails. Publication Status: Online-Only"
7185,7187d9596
< "Q9CQJ7-1","RefSeq","NP_001124526.1","28658604","Smurf1 interacts with and targets Securin, an inhibitor of sister-chromatid separation, for poly-ubiquitination and proteasomal degradation."
< "Q9CQJ7-1","RefSeq","NP_001124526.1","28516917","The findings show that maternal aging compromises the oocyte SAC-APC/C axis leading to a decrease in securin that ultimately causes sister chromatid cohesion loss. Publication Status: Online-Only"
< "Q9CQJ7-1","RefSeq","NP_001124526.1","27524416","High PTTG1 expression is associated with pituitary tumor development."
7199a9609,9610
> "Q60775-1","RefSeq","NP_031946.1","28954885","Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression Erratum:[J Immunol. 2018 Feb 23;:. PMID: 29475984]"
> "Q60775-1","RefSeq","NP_031946.1","28630061","Herein, the authors demonstrate that mice lacking Sts expression are significantly resistant to infection by the live vaccine strain of Francisella tularensis. Publication Status: Online-Only"
7201,7203c9612,9616
< "P0DPB4-1","RefSeq","NP_001106892.1","27979964","Work reveals that IQCJ-SCHIP1 interacts with several major nodal proteins, and we suggest that it contributes to a higher organizational level of the AnkG/betaIV-spectrin network critical for node integrity"
< "P0DPB4-1","RefSeq","NP_001106892.1","25950943","CK2-regulated IQJC-SCHIP-1 association with AnkG contributes to axon initial segment maintenance."
< "P0DPB4-1","RefSeq","NP_001106892.1","25953347","A new and early role for SCHIP1 during axon development and establishment of the anterior commissure, is identified."
---
> "Q8VDD8-1","RefSeq","NP_081109.1","25225459","WASH is required for the differentiation commitment of hematopoietic stem cells by acting as an upstream regulator to modulate c-Myc transcription."
> "Q8VDD8-1","RefSeq","NP_081109.1","24998208","WASH complex regulates Arp2/3 complex and is required for cytokinesis and polar body extrusion. Publication Status: Online-Only"
> "Q8VDD8-1","RefSeq","NP_081109.1","22718907","WASH-mediated F-actin is requisite for the integrity of both endosomal and lysosomal networks in mammalian cells."
> "Q8VDD8-1","RefSeq","NP_081109.1","20308062","WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells"
> "Q8VDD8-1","RefSeq","NP_081109.1","19922875","Show that WASH generates an actin network on a restricted domain of sorting and recycling endosomes."
7213,7216d9625
< "O08715-1","RefSeq","NP_001036006.1","30093535","Genetic disinhibition of Drp1 via knock-out of the mitochondrial protein kinase A (PKA) scaffold AKAP1 exacerbates stroke injury in mice. Mechanistically, we show that electron transport deficiency, increased superoxide production, and Ca(2+) overload result from genetic disinhibition of Drp1."
< "O08715-1","RefSeq","NP_001036006.1","29388469","Loss of AKAP1 expression is associated with acute lung injury."
< "O08715-1","RefSeq","NP_001036006.1","28569781","AKAP1 is a transcriptional target of Myc, and it supports mTOR pathway and the growth of cancer cells. Publication Status: Online-Only"
< "O08715-1","RefSeq","NP_001036006.1","28500286","These results identify a novel AKAP-mediated biochemical mechanism that increases TRPA1 sensitivity in peripheral sensory neurons, and likely contributes to persistent mechanical hypersensitivity. Publication Status: Online-Only"
7227a9637
> "Q922M3-1","RefSeq","NP_080421.2","25401743","Our studies suggest that KCTD10 plays crucial roles in embryonic angiogenesis and heart development in mammalians by negatively regulating the Notch signaling pathway. Publication Status: Online-Only"
7250a9661
> "Q8VCT3-1","RefSeq","NP_663392.2","15539558","Miniglucagon-generating endopeptidase is composed of NRDc and aminopeptidase B acting sequentially"
7269a9681,9683
> "B2RXA7-1","RefSeq","NP_001098671.1","31072004","We found that developing teeth from K14-CRE/Shhf/f mutant mice exhibit severe downregulation of Cyp26a1 and Cyp26c1 expression levels in the inner dental epithelium Publication Status: Online-Only"
> "B2RXA7-1","RefSeq","NP_001098671.1","15872003","Raldh2 and Cyp26 generate shifting boundaries of retionic acid activity, controlling hindbrain segmental gene expression."
> "B2RXA7-1","RefSeq","NP_001098671.1","15531370","Cyp26c1 degrades retinoic acid within the equatorial retina during later eye development."
7273,7275c9687,9690
< "Q00196-1","RefSeq","NP_001157028.1","26993806","Findings, combined with the predominantly B-cell-restricted expression of OCT2 and the absence of a systemic phenotype in our knockout mice, suggest that an OCT2-targeted therapeutic strategy would be efficacious in both major subtypes of DLBCL while avoiding systemic toxicity"
< "Q00196-1","RefSeq","NP_001157028.1","26361887","Overexpression of DDX60 did not potentiate IFN induction"
< "Q00196-1","RefSeq","NP_001157028.1","26016715","Oct2 mRNA expression was decreased in mice with either the ob/ob model or the methionine/choline deficiency model of nonalcoholic steatohepatitis."
---
> "O35083-1","RefSeq","NP_061350.3","28973305","Agpat1-/- mice developed widespread disturbances of metabolism, sperm development, and neurologic function resulting from disrupted phospholipid homeostasis. AGPAT1 appears to serve important functions in the physiology of multiple organ systems. The Agpat1-deficient mouse provides an important model in which to study the contribution of phospholipid and triacylglycerol synthesis to physiology and diseases."
> "O35083-1","RefSeq","NP_061350.3","20561744","Observations strongly implicate AGPAT1 in the development of skeletal muscle, specifically to terminal differentiation. These findings are linked to the regulation of actin cytoskeleton"
> "O35083-1","RefSeq","NP_061350.3","16150824","MAGPAT 1, 2, and 3 mRNA levels increased rapidly in mouse skin after acute permeability barrier disruption"
> "P16879-1","RefSeq","NP_034324.2","28463229","FES is a driver of melanoma progression in a mouse model."
7285a9701,9705
> "Q91VJ1-1","RefSeq","NP_001013801.2","30248400","The increased bacterial burden observed in vivo in AIM2 Knockout mice confirmed that AIM2 is essential for an effective innate immune response against Brucella infection."
> "Q91VJ1-1","RefSeq","NP_001013801.2","30587341","The in vivo short-term metastasis assay using orthotopic implantation into immunodeficient mice demonstrated that oral squamous cell carcinoma cells with high levels of AIM2 expression exhibited enhanced tumor growth in the tongue, resulting in decreased survival of the mice."
> "Q91VJ1-1","RefSeq","NP_001013801.2","19158676","Identification of AIM2 as an important inflammasome component that senses potentially dangerous cytoplasmic DNA, leading to activation of the ASC pyroptosome and caspase-1"
> "Q91VJ1-1","RefSeq","NP_001013801.2","19158675","Observations identify AIM2 as a new receptor for cytoplasmic DNA, which forms an inflammasome with the ligand and ASC to activate caspase-1"
> "Q91VJ1-1","RefSeq","NP_001013801.2","19131592","Study showed p202 is an inhibitor of DNA-induced caspase activation; conversely AIM2 was required for caspase activation by cytoplasmic dsDNA; work indicates HIN-200 proteins can act as pattern recognition receptors mediating response to cytoplasmic dsDNA"
7296a9717,9720
> "Q6S5I3-1","RefSeq","NP_955454.1","23499548","Visfatin enhances CAMP, hBD-2, hBD-3, and S100A7 production in human keratinocytes and their orthologs in murine imiquimod-treated psoriatic skin."
> "Q6S5I3-1","RefSeq","NP_955454.1","22158945","Data show that hS100A7 and mS100a7a15 overexpression induce proliferation and expression of inflammatory cytokines/chemokines."
> "Q6S5I3-1","RefSeq","NP_955454.1","16528363","The regulation, expression pattern and crosslinking of mS100A15 are consistent with the characteristics of the human orthologs, providing a valid surrogate model to study changes in these proteins associated with cutaneous pathologies."
> "Q6S5I3-1","RefSeq","NP_955454.1","15717926","These results support the hypothesis that the mouse S100A7 gene is structurally and functionally similar to human S100A7 and may offer a relevant model system for studying its normal biological function and putative role in tumor progression. S00A7 Publication Status: Online-Only"
7300a9725,9730
> "Q8K2H1-1","RefSeq","NP_780572.1","19621438","Results point to an indispensable function of periphilin during murine development and an important role in the nervous system, reflected by a strong and tightly regulated expression in the murine brain."
> "Q91ZD1-1","RefSeq","NP_473390.1","28731788","Osr2 controls multiple molecular pathways, including BMP and Sema3 signaling, in palate development."
> "Q91ZD1-1","RefSeq","NP_473390.1","16436053","Osr2 expression is regulated by C/EBP regulatory elements"
> "Q91ZD1-1","RefSeq","NP_473390.1","15670784","Our results indicate that Osr2 bifurcates its function by alternative splicing."
> "Q91ZD1-1","RefSeq","NP_473390.1","15175245","Osr2 is a key intrinsic regulator of palatal growth and patterning"
> "Q91ZD1-1","RefSeq","NP_473390.1","11520675","Expressed during craniofacial, limb, and kidney development"
7311,7317d9740
< "Q3UJD6-1","RefSeq","NP_082080.3","30386869","USP19 is an important regulator of fat development. Its inactivation in mice exerts effects on multiple tissues, which may protect against the negative metabolic effects of high-fat feeding."
< "Q3UJD6-1","RefSeq","NP_082080.3","29901692","USP19 modulates GR levels and in so doing may modulate both insulin and glucocorticoid signaling, two critical pathways that control protein turnover in muscle and overall glucose homeostasis."
< "Q3UJD6-1","RefSeq","NP_082080.3","28886438","Data suggest that expression of Usp19 in skeletal muscle can be regulated by dietary factors; here, supplementation with phytoestrogen daidzein down-regulates Usp19 expression via Esrb signaling and increases skeletal muscle mass. (Usp19 = ubiquitin-specific peptidase 19; Esrb = estrogen receptor beta)"
< "Q3UJD6-1","RefSeq","NP_082080.3","26048142","Expression of USP19 correlates with that of MuRF1 and MAFbx/atrogin-1 in skeletal muscles"
< "Q3UJD6-1","RefSeq","NP_082080.3","25568336","Deubiquitination by USP19 does modulate muscle cell differentiation and that this function requires the ER-localized isoform and appears to act through regulation of the unfolded-protein response (UPR) signaling."
< "Q3UJD6-1","RefSeq","NP_082080.3","21971047","E2 induces USP19 expression through nuclear ERalpha, (ii) increased USP19-mediated deubiquitinating activity represses myogenesis, and (iii) ERbeta inhibits ERalpha-activated USP19 expression."
< "Q3UJD6-1","RefSeq","NP_082080.3","19015242","Study reports that the USP19 deubiquitinating enzyme interacts with and stabilizes KPC1, thereby modulating p27(Kip1) levels and cell proliferation Erratum:[Mol Cell Biol. 2009 Jun;29(11):3241]"
7331a9755,9765
> "P06876-1","RefSeq","NP_034978.3","30778251","Findings identify myb proto-oncogene protein (c-Myb) as a pivotal regulator of CD8(+) T cell stemness and suggest its therapeutic potential."
> "Q8BGF0-1","RefSeq","NP_848852.1","21554246","Our findings indicate that AW551984 is a novel regulator of cardiomyogenesis from pluripotent embryonic cells, which links Wnt/beta-catenin signalling to Nkx2.5 expression."
> "Q9DBH0-1","RefSeq","NP_080106.1","31160553","Wwp2 has a role in protecting cartilage from osteoarthritis by suppressing Runx2-induced Adamts5 via Runx2 poly-ubiquitination and degradation. Publication Status: Online-Only"
> "Q9DBH0-1","RefSeq","NP_080106.1","30392800","Study delineatea a novel regulatory pathway that involves Sox9-[Wwp1/Wwp2/miR-140]-Fyn required for axon specification, acquisition of pyramidal morphology, and proper laminar distribution of cortical neurons."
> "Q9DBH0-1","RefSeq","NP_080106.1","29925997","Itch and WWP2 cooperate to regulate TH2 differentiation by enhancing the strength of the TCR signal via inducing atypical ubiquitination of the phosphatase SHP-1."
> "Q9DBH0-1","RefSeq","NP_080106.1","29685889","The results demonstrate that WWP2, rather than CHIP, is an ubiquitin ligase that promotes PTEN degradation in vivo."
> "Q9DBH0-1","RefSeq","NP_080106.1","29695789","Letter: conclude that expression of miR-140, and not Wwp2 protein is required for proper craniofacial development."
> "Q9DCT8-1","RefSeq","NP_077185.1","29662084","HOXA9 inhibits HIF1A-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development. Publication Status: Online-Only"
> "Q9DCT8-1","RefSeq","NP_077185.1","21601656","The persistence of Crip2 expression in cardiovascular tissues implies that Crip2 might exert an important impact on the cardiovascular development, maintenance and homeostasis."
> "Q9DCT8-1","RefSeq","NP_077185.1","12839623","Observed characteristics of the LIM domain-containing adaptor protein CRIP2 are consistent with a potential role of PTP-BL in the dynamics of the cortical actin cytoskeleton"
> "Q9DCT8-1","RefSeq","NP_077185.1","12128222","Role for the two LIM-domain gene Hlp in the very earliest stages of heart differentiation and development"
7339a9774,9784
> "Q504P2-1","RefSeq","NP_808354.1","28578388","The effects of CLEC12A blocking were further validated using CLEC12A knockout (KO) animals wherein EAE disease induction was delayed and reduced disease severity was observed. These studies reveal the utility of a DC-specific mechanism in designing new therapeutics for MS. Publication Status: Online-Only"
> "Q504P2-1","RefSeq","NP_808354.1","27978488","Clec9A and Clec12A exhibit different intrinsic capacities to elicit MHC I and MHC II presentation following direct antigen targeting"
> "Q504P2-1","RefSeq","NP_808354.1","26095365","Clec12a(-/-) mice are more susceptible to Salmonella infection, supporting a role for CLEC12A in antibacterial defense pathways in vivo."
> "Q504P2-1","RefSeq","NP_808354.1","19494282","Anti-Clec12A mAb alone produced only moderate responses, but these were amplified by coinjecting only small amounts of LPS as a dendritic cell activation agent"
> "Q504P2-1","RefSeq","NP_808354.1","18350551","MMICL recognises an endogenous ligand in a variety of murine tissues, suggesting that the receptor plays a role in homeostasis"
> "Q504P2-1","RefSeq","NP_808354.1","17609428","CLL-1 expression is also present on the CD34(+)CD38(-) stem- cell compartment in acute myeloid leukemia"
> "Q504P2-1","RefSeq","NP_808354.1","15238421","The molecular cloning, tissue distribution, and functional characterization of a novel NK cell receptor, KLRL1, from human and mouse dendritic cells [KLRL1]"
> "P70451-1","RefSeq","NP_032026.2","27401557","Levels of FER were elevated in ovarian cancer cell lines relative to those in immortalized normal surface epithelial cells and that suppression of FER attenuated the motility and invasive properties of these cancer cells"
> "P70451-1","RefSeq","NP_032026.2","27226326","Sperm from mice targeted with a kinase-inactivating mutation in Fer failed to undergo capacitation-associated increases in tyrosine phosphorylation."
> "P70451-1","RefSeq","NP_032026.2","25237066","Directed mitochondrial accumulation of FerT endowed nonmalignant cells with tumor-forming ability"
> "P70451-1","RefSeq","NP_032026.2","23589302","A critical role of Fer in PDGF-BB-induced STAT3 activation and cell transformation."
7344a9790,9792
> "Q8BGU2-1","RefSeq","NP_766221.1","30287486","Cbln2 and Cbln4 are expressed in distinct MHb neurons that contribute to different behaviors."
> "Q8BGU2-1","RefSeq","NP_766221.1","29784783","Findings demonstrate that hippocampal synapse assembly and maintenance require a tripartite molecular complex in which the ligand Cbln2 binds with presynaptic neurexin 1beta (+S4) and postsynaptic GluD1."
> "Q8BGU2-1","RefSeq","NP_766221.1","23853053","That neurons expressing Cblns 1, 2, and 4 tend to occupy different laminar positions within the dorsal spinal cord"
7346a9795,9800
> "Q5UAK0-3","RefSeq","NP_081972.2","26938916","Biochemical analysis of the BAHD1-associated multiprotein complex identifies MIER proteins as novel partners of BAHD1 and suggests that BAHD1-MIER interaction forms a hub for histone deacetylases and methyltransferases Publication Status: Online-Only"
> "Q5UAK0-3","RefSeq","NP_081972.2","17622490","This study represents the first immunohistochemical analysis of MI-ER1alpha expression in mammals."
> "Q5UAK0-3","RefSeq","NP_081972.2","16147882","Characterization of the mouse ortholog of mi-er1 Erratum:[DNA Seq. 2005 Oct;16(5):402]"
> "P20065-1","RefSeq","NP_067253.1","30226623","Tb4 induced BSP expression in MDPC23 cells via ERK and Smad3 signaling pathways, suggesting its role as a signaling molecule in odontoblasts for regulating BSP secretion during dentinogenesis."
> "P20065-1","RefSeq","NP_067253.1","29864422","Tmsb4X was up-regulated in Crybb2 mutant brain. Additionally, Tmsb4X was co-expressed with Crybb2 at actin-enriched cell ruffles. Over-expression of Tmsb4X in cultured hippocampal neurons inhibited dendritogenesis, which phenocopied Crybb2 knock-down."
> "P20065-1","RefSeq","NP_067253.1","27914791","Our data suggest that Tbeta4 is required for setting correct sarcomere length and for appropriate splicing of titin, not only in the heart but also in skeletal muscle."
7353a9808,9811
> "Q99LT0-1","RefSeq","NP_077746.3","30448059","These results reveal a critical role of DPY30 in glucose homeostasis."
> "Q99LT0-1","RefSeq","NP_077746.3","27647347","Dpy30-deficient hematopoietic stem and progenitor cells cannot differentiate or efficiently up-regulate lineage-regulatory genes, and eventually fail to sustain for long term."
> "Q99LT0-1","RefSeq","NP_077746.3","26691508","Dpy30 role in cellular reprogramming and its interactions with Set1 complex Publication Status: Online-Only"
> "Q99LT0-1","RefSeq","NP_077746.3","21335234","Results indicate an essential functional role for Dpy-30 and SET1/MLL complex-mediated H3K4 methylation, as a component of the bivalent mark, at developmental genes during the embryonic stem cells fate transitions. Erratum:[Cell. 2011 Mar 4;144(5):825]"
7367a9826,9827
> "Q8VH31-1","RefSeq","NP_620404.1","12525704","RFPL4 functions as an E3 ubiquitin protein ligase to regulate protein degradation and meiosis in mouse oocytes."
> "Q8VH31-1","RefSeq","NP_620404.1","11850190","The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells."
7371,7376d9830
< "Q8K3J5-1","RefSeq","NP_001289476.1","29750959","ZNF131 suppresses expression of Cdk inhibitor, p21(cip1), and that of pro-apoptotic factors, Bax and Puma, targets of p53, to facilitate cell cycle progression and suppress unnecessary apoptosis, respectively, of pro-B cells."
< "Q8K3J5-1","RefSeq","NP_001289476.1","28882591","We also demonstrate that Kaiso inhibits Znf131 expression, raising the possibility that Kaiso and Znf131 act to fine-tune target gene expression. Together, our findings implicate Znf131 as a co-regulator of Kaiso-mediated biological processes."
< "Q8K3J5-1","RefSeq","NP_001289476.1","26136427","Znf131 is critical for T cell development during double-negative to double-positive stage, with which significant cell expansion triggered by the pre-TCR signal is coupled."
< "Q8K3J5-1","RefSeq","NP_001289476.1","20303951","Znf131 is a transcriptional activator, a less common function of POZ-ZF proteins, that is negatively regulated by its heterodimerization partner Kaiso."
< "Q8K3J5-1","RefSeq","NP_001289476.1","17306895","The mechanism of Znf131 nuclear localization, is reported."
< "Q8K3J5-1","RefSeq","NP_001289476.1","12163020","Results suggest that Znf131/ZNF131 plays a role during development and organogenesis as well as in the function of the adult central nervous system."
7377a9832,9836
> "P05480-1","RefSeq","NP_033297.2","30685263","C-Src-mediated regulation of Nrf2 transcriptional activity, via PKCdelta activation."
> "P05480-1","RefSeq","NP_033297.2","30823936","This study identifies a so-far undescribed mechanism of Shp1/Src modulation that promotes cell motility and that is dependent on the cPLA2 metabolite glycerophosphoinositol 4-phosphate. Publication Status: Online-Only"
> "P05480-1","RefSeq","NP_033297.2","30462575","He ability of beta3 integrins to specifically sense local tensional organization is mostly encoded by its cytoplasmic domain and is regulated by tuning the affinity of its NPXY domains through phosphorylation by Src family kinases. Erratum:[Mol Biol Cell. 2019 Mar 1;30(5):729. PMID: 30817248]"
> "P05480-1","RefSeq","NP_033297.2","29653289","A previously unknown role for Src in regulating cell division orientation in relation to the pre-division geometry of mother cells, which may contribute to the misoriented cell division, is reported."
> "P05480-1","RefSeq","NP_033297.2","29651879","Src kinase activation by nitric oxide promotes resistance to anoikis in tumor cell lines."
7388a9848,9849
> "P97868-1","RefSeq","NP_778188.1","17470788","The PACT-p53 interaction plays a critical role in embryonic development and tumorigenesis and identify PACT as a member of negative regulators of p53."
> "P97868-1","RefSeq","NP_778188.1","15617101","P2P-R expression may be translationally regulated by PUM2 and that P2P-R may modulate translation by influencing ribosomal protein gene expression"
7396,7399d9856
< "Q9D2H6-1","RefSeq","NP_001074433.1","30337366","A mechanism by which the DNA binding-independent activity of Sp2 potentiates genomic loading of Pbx1:Prep1 and Nf-y to composite motifs present in many promoters of highly expressed genes"
< "Q9D2H6-1","RefSeq","NP_001074433.1","27191968","SP2 as important factor responsible for higher Cd14 expression and reduced IBD susceptibility mediated by the C3Bir allele. Publication Status: Online-Only"
< "Q9D2H6-1","RefSeq","NP_001074433.1","25793500","Our results unveil strikingly different recruitment mechanisms of Sp1/Sp2/Sp3 transcription factor members uncovering an unexpected layer of complexity in their binding to chromatin in vivo. Publication Status: Online-Only"
< "Q9D2H6-1","RefSeq","NP_001074433.1","23293287","Sp2 deletion disrupts neurogenesis in the embryonic and postnatal brain."
7403a9861,9862
> "Q9Z1A1-1","RefSeq","NP_062652.1","29026155","TFG in pancreatic beta-cells plays a vital role in maintaining both the mass and function of beta-cells, and its dysfunction increases the tendency to develop glucose intolerance. Publication Status: Online-Only"
> "Q9Z1A1-1","RefSeq","NP_062652.1","23479643","Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure."
7410a9870,9873
> "P61148-1","RefSeq","NP_034327.1","30063763","MiR-18a participates in the regulation of proliferation by partly decreasing the expression of Fgf1. Publication Status: Online-Only"
> "P61148-1","RefSeq","NP_034327.1","29845277","The present results provided evidence that aFGF accelerates the progression of atherosclerosis and suggested that aFGF may be a potential therapeutic target for the prevention of atherosclerosis development."
> "P61148-1","RefSeq","NP_034327.1","29268138","TUG1 knockdown ameliorates atherosclerosis by modulating FGF1 via miR-133a in ApoE knockout mice."
> "P61148-1","RefSeq","NP_034327.1","29360039","Here, we show that the Crk family of adaptor proteins, Crk and Crkl, are required for mouse lens morphogenesis but not differentiation upon Fibroblast Growth Factor stimulation. Publication Status: Online-Only"
7416a9880,9885
> "Q9JJT2-1","RefSeq","NP_064398.1","16497798","GFRalpha4 signaling has a role in regulating calcitonin production in thyroid C cells of young mice"
> "Q99N50-1","RefSeq","NP_113571.2","24284068","Our findings indicate that Slp2-a controls renal cell size through regulation of Rap-ezrin signaling independently of Rab27."
> "Q99N50-1","RefSeq","NP_113571.2","22767581","Slp2-a is required for targeting of the signaling molecule podocalyxin to the apical membrane in a Rab27A-dependent manner."
> "Q99N50-1","RefSeq","NP_113571.2","20729199","Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons"
> "Q99N50-1","RefSeq","NP_113571.2","15543135","Loss of Slp2-a protein also induced a change in melanocyte morphology, from their normal elongated shape to a more rounded shape, which depended on the phospholipid-binding activity of Slp2-a"
> "Q99N50-1","RefSeq","NP_113571.2","11773082","Synaptotagmin-like protein 2-a (Slp2-a) contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slp2-a specifically and directly binds the GTP-bound form of Rab27A."
7423,7425d9891
< "Q80TH2-3","RefSeq","NP_001276402.1","29980571","Tumor organoids derived from Erbin/Apc double knockout mice displayed increased tumor initiation potential and activation of Wnt signaling"
< "Q80TH2-3","RefSeq","NP_001276402.1","26025865","Overexpression of FHL2 alone had no effect on Erbin expression, but in the presence of MITF, Erbin expression was decreased."
< "Q80TH2-3","RefSeq","NP_001276402.1","26056141","By degrading Erbin and Nrf2, Sag activates the Ras-Raf pathway and causes ROS accumulation to trigger autophagy and senescence"
7439a9906,9907
> "Q8BGY6-1","RefSeq","NP_473393.2","21087515","Results demonstrate that Lc3 synthase and lacto-neolacto series gangliosides are essential to multiple physiological functions, especially the control of reproductive output, and spleen B-cell abnormality. Publication Status: Online-Only"
> "Q8BGY6-1","RefSeq","NP_473393.2","19014510","B3gnt5 is essential to pre-implantation development of the murine embryo. Publication Status: Online-Only"
7446a9915,9916
> "Q5D525-1","RefSeq","NP_083415.1","16328886","An isoform of 4930481F22, lacking the 7th exon, encodes a putative 28.4 kDa protein expressed in spermatocytes, and may have an important role in meiosis."
> "Q9QUK0-1","RefSeq","NP_796244.2","14605869","Cdkl2 functions mainly in mature neurons and that mechanisms governing regulation of this gene expression in mice are distinct from those of immediate-early genes."
7450,7452c9920,9924
< "Q4KMM3-1","RefSeq","NP_001123638.1","29905912","We present a dysregulation of metabolites of glucose metabolism at the pre-symptomatic stage in the Oxr1 knockout cerebellum. We then demonstrate that Oxr1 and Gpi1 physically and functionally interact and that the level of Gpi1 oligomerisation is disrupted when Oxr1 is deleted in vivo. Furthermore, we show that Oxr1 modulates the additional and less well-understood roles of Gpi1 as a cytokine and neuroprotective factor."
< "Q4KMM3-1","RefSeq","NP_001123638.1","27036366","Screening a panel of proteins that regulate mitochondrial morphology in bella GCs revealed de-regulation of phospho-Drp1(Ser616), a key mitochondrial fission regulatory factor. Our data provide new insights into the function of Oxr1, revealing that specific isoforms of this novel antioxidant protein are associated with mitochondria."
< "Q4KMM3-1","RefSeq","NP_001123638.1","25753484","Identify OXR1 as the first neuron-specific antioxidant modulator of pathogenesis and disease progression in SOD1-mediated amyotrophic lateral sclerosis"
---
> "Q9QXX4-1","RefSeq","NP_056644.1","12084073","Expression of the aspartate/glutamate mitochondrial carriers aralar1 and citrin during development(CITRIN)"
> "P32067-1","RefSeq","NP_033304.1","28223366","La deletion is associated with Neuron Death and Reactive Astrocytosis. Publication Status: Online-Only"
> "P32067-1","RefSeq","NP_033304.1","24190965","Data indicate that La antigen (Sjogren's syndrome antigen B) is essential in different cell types and required for normal development of various tissue types."
> "P32067-1","RefSeq","NP_033304.1","21343359","Overexpression of mouse or human La enhanced M-MuLV particle release in the absence of glycosylated gag. Publication Status: Online-Only"
> "P32067-1","RefSeq","NP_033304.1","18836485","La appears to be an important contributor to Akt-mediated translational regulation of these transcripts in murine glial cells."
7455a9928,9931
> "O09046-1","RefSeq","NP_034345.2","29288206","IL4I1 negatively controls B-Cell Antigen Receptor-dependent B cell activation."
> "O09046-1","RefSeq","NP_034345.2","27797811","IL4I1 promotes central nervous system remyelination and axonal integrity."
> "O09046-1","RefSeq","NP_034345.2","26599209","Our findings indicate that IL4I1 promotes an enhanced M2 functional phenotype. Publication Status: Online-Only"
> "O09046-1","RefSeq","NP_034345.2","21469114","Inhibits CD8+ antitumor T-cell response in vivo"
7465,7469c9941,9944
< "Q80YE7-1","RefSeq","NP_001272846.1","30120735","Activation of DAPK1 impairs learning and memory by degrading Caytaxin during aging."
< "Q80YE7-1","RefSeq","NP_001272846.1","29317503","Promoting ER stress-ATF6-DAPK1 signaling in transporting enterocytes counters the transcellular passage of bacteria evoked by dysfunctional mitochondria"
< "Q80YE7-1","RefSeq","NP_001272846.1","28731405","Excitotoxicity can proceed without increased Ser-1303 phosphorylation, and is unaffected by Dapk1 deficiency in vitro or following ischemia in vivo. Publication Status: Online-Only"
< "Q80YE7-1","RefSeq","NP_001272846.1","28614711","Authors find that the LTP specificity of CaMKII synaptic accumulation is due to its LTD-specific suppression by calcineurin (CaN)-dependent DAPK1 activation, which in turn blocks CaMKII binding to GluN2B."
< "Q80YE7-1","RefSeq","NP_001272846.1","14530257","Cellular activities of DAPK are critical for antagonizing caspase-dependent apoptosis to promote cell survival under normal cell growth conditions."
---
> "Q8CCE9-1","RefSeq","NP_031919.2","27621446","These data identify E4F1 as a master regulator of the PDC."
> "Q8CCE9-1","RefSeq","NP_031919.2","27621431","These data reveal a central role for Dlat in the metabolic program regulated by E4F1 in basal keratinocytes."
> "Q8CCE9-1","RefSeq","NP_031919.2","25843721","Acute inactivation of E4F1 in these cells results in CHK1-dependent checkpoint deficiency and multiple mitochondrial dysfunctions that lead to increased ROS production, energy stress, and inhibition of de novo pyrimidine synthesis"
> "Q8CCE9-1","RefSeq","NP_031919.2","25843717","Altogether, our results classify E4F1 as a master regulator of CHK1 activity that ensures high fidelity of DNA replication, thus safeguarding genome stability."
7473d9947
< "D3Z7P3-1","RefSeq","NP_001074550.1","30472430","Results show that GLS1 mutant mice display moderate impairments of hippocampal glutamatergic neurotransmission and moderate changes in adaptive behaviors that have been shown to participate to the development of depressive-like state."
7487a9962,9963
> "O54830-1","RefSeq","NP_032956.1","12399423","Results show that PRL-like proteins E and F have the same stimulatory effects on megakaryocyte growth and differentiation"
> "O54830-1","RefSeq","NP_032956.1","12040023","Injection of PLP-E into thrombocytopenic mice restores normal platelet levels with no effect on granulocytes, erythrocytes, and total white blood cell counts"
7510a9987
> "Q8VHP7-1","RefSeq","NP_766640.1","12189154","CDNA cloning, gene structure and biological characterization homologous to human MNEI"
7512a9990,9992
> "Q62556-1","RefSeq","NP_038511.1","21915327","Data illustrated the importance of Akt1 in mammary epithelial cell proliferation, as well as in the regulation of Btn1a1 and subsequent expression of ss-casein."
> "Q62556-1","RefSeq","NP_038511.1","20208008","These data are consistent with a coinhibitory role for mouse Butyrophilins"
> "Q62556-1","RefSeq","NP_038511.1","19531472","PRY/SPRY/B30.2 domain of butyrophilin 1A1 (BTN1A1) binds to xanthine oxidoreductase"
7519a10000,10001
> "Q07279-1","RefSeq","NP_032711.2","29476075","We detected that cigarette smoke significantly increased p45 NFE2 levels in DJ-1 KO mice compared to wild-type mice. Our results indicate that p45 NFE2 expression is induced by exposure to cigarette smoke, has a cytoprotective activity against cell injury, and its downregulation in human primary ATII cells may contribute to emphysema pathogenesis Publication Status: Online-Only"
> "Q07279-1","RefSeq","NP_032711.2","28411267","Under the obese condition, activation of the hepatic NFE2/miR-423-5p axis plays important roles in the progression of type 2 diabetes and NAFLD by repressing the FAM3A-ATP-Akt signaling pathway."
7530,7533d10011
< "P98083-1","RefSeq","NP_001106802.1","30207172","Document a genetic link between the p66ShcA locus and accelerated aging phenotype(s) in kidneys of diabetic mice."
< "P98083-1","RefSeq","NP_001106802.1","30091687","These results suggest that p66Shc may regulate the relative abundance and timing of lineage-associated transcription factor expression in the blastocyst inner cell mass ."
< "P98083-1","RefSeq","NP_001106802.1","30047409","A complex epigenetic mechanism linking miRNAs and chromatin modifying enzymes drive persistent p66 Shc transcription and reactive oxygen species generation."
< "P98083-1","RefSeq","NP_001106802.1","29930100","Genetic inhibition of ShcA signaling in the Polyoma virus middle T (MT) breast cancer mouse model sensitized mammary tumors to biguanides during the earliest stages of breast cancer progression."
7541,7542d10018
< "Q8BH60-1","RefSeq","NP_001186201.1","20958966","PIST protein, mouse plays an important role in regulating the intracellular sorting/ localization of cadherin 23. Publication Status: Online-Only"
< "Q8BH60-1","RefSeq","NP_001186201.1","12149515","Predominantly localized at the trans-Golgi region in round spermatids; male mice in which GOPC has been disrupted are infertile with globozoospermia"
7556a10033,10036
> "Q7TNK1-1","RefSeq","NP_081965.2","29298325","Provide a novel conditional KO animal model in which to investigate the downstream genes directly and/or indirectly regulated by RFX4 isoform 1. This model could provide new insights into the pathogenesis of obstructive hydrocephalus and holoprosencephaly in humans, both relatively common and disabling birth defects Publication Status: Online-Only"
> "Q7TNK1-1","RefSeq","NP_081965.2","14701801","Mouse regulatory factor X4 transcript is expressed in the suprachiasmatic nucleus and regulated by light"
> "Q7TNK1-1","RefSeq","NP_081965.2","12925582","Data implicate the RFX4_v3 variant transcript as being crucial for early brain development, as well as for the genesis of the subcommissural organ."
> "Q8BGC3-1","RefSeq","NP_766426.1","21778275","A model whereby the SLC16A12 (c.643C>T) mutation causes juvenile cataract by a defect in protein trafficking rather than by haploinsufficiency. Publication Status: Online-Only"
7563a10044
> "Q6PE87-1","RefSeq","NP_081317.4","17971504","1700003M02Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons and testis, and is predicted to be important to cilia."
7565a10047
> "O88425-1","RefSeq","NP_061227.1","22899353","Nme6 or Nme7 can regulate several critical processes in embryonic stem cell renewal."
7589,7590c10071,10073
< "Q61701-1","RefSeq","NP_034618.2","31013625","We demonstrated HuD downregulation and HuB upregulation in DRG sensory neurons induced by diabetes, which might be correlated with altered post-transcriptional control of RNAs involved in the regulation of thermal hypoalgesia condition caused by the advanced diabetic neuropathy. Publication Status: Online-Only"
< "Q61701-1","RefSeq","NP_034618.2","30014466","HuD enhanced p27 mRNA translation by interacting with both the 5'-untranslated region (UTR) and the 3'-UTR of p27 mRNA, and consequently suppressed cell cycle progression and growth of pancreatic neuroendocrine tumors."
---
> "P50431-1","RefSeq","NP_033197.2","23700346","Shmt1 and dietary folate deficiency influence metabolic markers of homocysteine remethylation in mice."
> "Q8BGM5-1","RefSeq","NP_001123666.1","20407206","Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon"
> "Q8BGM5-1","RefSeq","NP_001123666.1","18385076","Best2 plays a role in the generation of IOP by regulating formation of aqueous humor, and inhibition of Best2 function represents an attractive new avenue for regulating IOP in individuals with glaucoma."
7594a10078,10085
> "Q9CQK8-1","RefSeq","NP_035598.2","25123441","Sprr2a is selectively expressed in the upper layer of the epithelium surrounding taste buds in the circumvallate papilla"
> "Q9CQK8-1","RefSeq","NP_035598.2","23735658","Immunohistochemical staining revealed that Sprr2a protein is detected only in the adult uterus, and not in the ovary, oviduct or testis."
> "Q9CQK8-1","RefSeq","NP_035598.2","21458245","In non-lesional HPV8-CER transgenic skin StefinA and Sprr2 are indirect/direct transcriptional targets of HPV8"
> "Q9CQK8-1","RefSeq","NP_035598.2","18155796","Small proline-rich proteins (SPRR2A) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes."
> "Q60778-1","RefSeq","NP_035038.2","26342031","These results mechanistically link the innate immune response mediated by IkappaBbeta/NF-kappaB to ET-1 expression and potentially reveal therapeutic targets for patients with Gram-negative septic shock."
> "Q60778-1","RefSeq","NP_035038.2","25946967","IkappaBbeta has essential functions within the Rel-NFkappaB generation module, specifically for the RelA:RelA homodimer, which controls a subset of NFkappaB target genes. Publication Status: Online-Only"
> "Q60778-1","RefSeq","NP_035038.2","24973451","Dengue virus protease interacts with both IkappaBalpha and IkappaBbeta cleaving them in a mouse hemorrhage model."
> "Q60778-1","RefSeq","NP_035038.2","24066808","Sustained NF-kappaB activity mediated by IkappaBbeta protects against hyperoxic lung injury through increased expression of antiapoptotic genes"
7601a10093,10105
> "Q5HZI1-1","RefSeq","NP_001273342.1","26471325","Important role in AT2 receptor-mediated PPARgamma activation"
> "Q5HZI1-1","RefSeq","NP_001273342.1","24288149","ATIPs seem to be mainly involved in the developmental regulation of the cardiovascular system and may act in different AT2-dependent and -independent manners."
> "Q5HZI1-1","RefSeq","NP_001273342.1","23396587","Analysis of a functional ATIP3 domain that associates with microtubules and recapitulates the effects of ATIP3 on microtubule dynamics, cell proliferation, and migration in breast cancer"
> "Q5HZI1-1","RefSeq","NP_001273342.1","23565185","ATIP1 could exert anti-inflammatory effects in adipose tissue via macrophage polarization associated with improvement of insulin resistance."
> "Q5HZI1-1","RefSeq","NP_001273342.1","22200760","Reports the first generation of a MTUS1 KO mouse, developing spontaneous heart hypertrophy and increased cell proliferation, confirming once more the anti-proliferative effect of MTUS1, and a SLE-like lymphoproliferative disease."
> "Q5HZI1-1","RefSeq","NP_001273342.1","15123706","Results identify ATIP1 (angiotensin II AT2 receptor-interacting protein) as a novel early component of growth inhibitory signaling cascade."
> "Q91XE4-1","RefSeq","NP_001289411.1","23010594","Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C virus that may by implicated in HCV pathogenesis."
> "Q91XE4-1","RefSeq","NP_001289411.1","20921362","Structures, in conjunction with biochemical data, indicated that AA3 mediates substrate specificity through van der Waals interactions providing a dynamic interaction interface, which facilitates a diverse range of substrates"
> "Q91XE4-1","RefSeq","NP_001289411.1","17434493","A 16A resolution model of the AAIII dimer."
> "Q91XE4-1","RefSeq","NP_001289411.1","14656720","Data suggest that in kidney proximal tubules, aminoacylase III plays an important role in deacetylating mercapturic acids"
> "Q99JS0-1","RefSeq","NP_851390.1","18650334","This study identified an evolutionarily conserved novel component of myelin called Mp11. The Mp11 genomic locus contains multiple conserved Egr binding sites, and Mp11 induction is regulated by the expression of Egr2 and expression in peripheral nerve."
> "Q8CBQ5-1","RefSeq","NP_083020.2","16949365","UV irradiation increases nuclear PtdIns5P levels via inhibition of the activity of the beta isoform of PtdIns5P 4-kinase (PIP4Kbeta), an enzyme that can phosphorylate and remove PtdIns5P."
> "Q8CBQ5-1","RefSeq","NP_083020.2","12011096","PI 4-kinase functions to negatively regulate GLUT4 translocation through its interaction with NCS-1."
7602a10107,10108
> "P47857-1","RefSeq","NP_067489.3","29655163","Insulin, the most known regulator of glucose consumption, specifically regulates the expression of PFKL and PFKM, which impact the regulation of glycolysis in the cell."
> "P47857-1","RefSeq","NP_067489.3","27146165","This study demonstrated that the reveal PFK-1 as an important regulator of neurogenesis."
7605,7607c10111,10112
< "G5E8K5-1","RefSeq","NP_666117.2","30562487","Results indicate an obligatory role for ankyrin-G protein (AnkG) in lens morphogenesis and growth."
< "G5E8K5-1","RefSeq","NP_666117.2","30046097","ANK3 functions in neuronal microtubule dynamics through GSK3 and its downstream substrate CRMP2. Publication Status: Online-Only"
< "G5E8K5-1","RefSeq","NP_666117.2","29963618","Study shows that simultaneous ablation of neuronal Neurofascin and Ankyrin G in young and adult mice reveals age-dependent increase in nodal stability in myelinated axons and differential effects on the lifespan. Publication Status: Online-Only"
---
> "Q02853-1","RefSeq","NP_032632.1","27126782","Strikingly, MMP11 overexpression protects against type 2 diabetes while Mmp11-/- mice exhibit hallmarks of metabolic syndrome. Erratum:[Sci Rep. 2016 May 31;6:26916. PMID: 27243941] Publication Status: Online-Only"
> "Q02853-1","RefSeq","NP_032632.1","24141782","Results show that MMP-11 has a paracrine function during mammary gland development that might be harnessed to promote tumor progression, exposing a new link between development and malignancy."
7611a10117,10118
> "Q9JII7-1","RefSeq","NP_579927.1","24898249","Arsenite- inducible regulatory particle-associated protein (AIRAP) transcript to be translationally induced during arsenite stress conditions."
> "Q9JII7-1","RefSeq","NP_579927.1","16973439","AIRAP adapts the cell's core protein degradation machinery to counteract proteotoxicity induced by an environmental toxin."
7627,7630c10134,10140
< "O88559-1","RefSeq","NP_001161961.1","30315824","Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia."
< "O88559-1","RefSeq","NP_001161961.1","30099020","Results showed that the MEN1 gene was negatively correlated with lung fibrinogen markers and provide evidence that MEN1 plays a key role in the formation of pulmonary fibrosis by regulating the secretion of TGF-beta and the activation of TGF-beta/Smads signaling pathway."
< "O88559-1","RefSeq","NP_001161961.1","30220511","A distinct astroglial role for menin was identified in regulation of neuroinflammation in depression."
< "O88559-1","RefSeq","NP_001161961.1","30120246","Menin maintains the T-cell functions by limiting mTORC 1 activity and subsequent cellular metabolism. Publication Status: Online-Only"
---
> "Q3USQ7-1","RefSeq","NP_001028506.1","16359841","Significant down-regulation of capucin mRNA levels in two rodent models of Huntington disease, indicating a possible contribution to the pathogenesis of this disorder"
> "Q9ET54-1","RefSeq","NP_001280703.1","29720549","Taken together, this study demonstrates that palladin plays an important role in themorphology and dynamic behavior of podocytes in vivo and in vitro."
> "Q9ET54-1","RefSeq","NP_001280703.1","29712777","Palladin operates downstream of mTOR to modulate axon morphogenesis"
> "Q9ET54-1","RefSeq","NP_001280703.1","28739877","These results show a new function for PALLD as a crucial regulator of the early phase of phagocytosis by elaborating dynamic actin polymerization and depolymerization"
> "Q9ET54-1","RefSeq","NP_001280703.1","28340616","Study shows palladin is expressed with proper spatio-temporal pattern in the neural folds. It plays a crucial role in regulating mouse cranial neural tube closure by modulating cytoskeleton, proliferation, differentiation, apoptosis, and adhesion of neural epithelium Publication Status: Online-Only"
> "Q9ET54-1","RefSeq","NP_001280703.1","27865965","The aggregation of palladin(+/-) platelets was increased in response to low levels of thrombin, U46619, and collagen. This study also reports enhanced spreading of palladin(+/-) platelets on immobilized fibrinogen (Fg) and increased rate of clot retraction in platelet-rich plasma (PRP) containing palladin(+/-) platelets."
> "Q9ET54-1","RefSeq","NP_001280703.1","14983521","The actin-associated protein palladin may play an important role in recruiting VASP to sites of actin filament growth, anchorage, and crosslinking."
7655,7664c10165,10173
< "Q6NZQ8-1","RefSeq","NP_001280713.1","30356278","Results show that MARCH1 deficiency results in sex-specific changes in body weight, adiposity, and increases glucose clearance. Genetic association study for MARCH1 in type 2 diabetes risk in publicly-available datasets found evidence suggestive of association. These data show a link between immune function and diabetes implicating MARCH1 as a regulator of lipid metabolism and glucose tolerance in sex-specific manner. Publication Status: Online-Only"
< "Q6NZQ8-1","RefSeq","NP_001280713.1","30154416","Study shows march1-dependent modulation of donor MHC II on CD103(+) dendritic cells mitigates alloimmunity Publication Status: Online-Only"
< "Q6NZQ8-1","RefSeq","NP_001280713.1","30001419","Unexpected intersection between MHC I and MHC II such that the surface expression of both molecules are indirectly and directly regulated by MARCH1 ubiquitination, respectively. Publication Status: Online-Only"
< "Q6NZQ8-1","RefSeq","NP_001280713.1","29854835","These results demonstrate a role of March1 E3 ubiquitin ligase in modulating allergic responses Publication Status: Online-Only"
< "Q6NZQ8-1","RefSeq","NP_001280713.1","29378848","Found downstream sequence elements, present in the first coding exon of March-I in antigen-presenting cells (APCs), that confer regulation of March-I expression in activated APCs"
< "Q6NZQ8-1","RefSeq","NP_001280713.1","21220452","Found that the transmembrane domain of CD83 enhances MHC class II and CD86 expression by blocking MHC class II association with the ubiquitin ligase MARCH1"
< "Q6NZQ8-1","RefSeq","NP_001280713.1","21059907","Selective ubiquitination of MHC-II in immature dendritic cells by the E3 ubiquitin ligase March-I results in the selective degradation of internalized pMHC-II."
< "Q6NZQ8-1","RefSeq","NP_001280713.1","19917682","MARCH-I may function as a housekeeper of conventional dendritic cell in the steady state."
< "Q6NZQ8-1","RefSeq","NP_001280713.1","19880452","MARCH1 expression is regulated at a posttranscriptional level by trafficking within the endolysosomal pathway where MARCH1 is proteolyzed."
< "Q6NZQ8-1","RefSeq","NP_001280713.1","17255932","The function of MHC II in B cells is regulated through ubiquitination by MARCH-I."
---
> "Q8C767-1","RefSeq","NP_808409.1","29266543","Mice lacking protein phosphatase 1 regulatory subunit 3B (PPP1R3B) were deficient in hepatic glycogen, whereas HTGC was unchanged. Hepatic overexpression of PPP1R3B caused accumulation of hepatic glycogen and elevated plasma levels of ALT, but did not change HTGC"
> "Q8C767-1","RefSeq","NP_808409.1","28473467","Findings indicate a major role for Ppp1r3b in regulating hepatic glycogen stores and whole-body glucose/energy homeostasis."
> "Q8C767-1","RefSeq","NP_808409.1","16949035","Analysis of expression of alternative splice variants of the mouse Ppp1r3b gene in lung epithelial cells"
> "Q8BHY3-1","RefSeq","NP_848757.4","30156115","Loss of TMEM16A resulted in reduced nephron number and, subsequently, albuminuria and tubular damage."
> "Q8BHY3-1","RefSeq","NP_848757.4","30311910","We demonstrate the electrostatic control of permeation by the bound calcium ions in mouse TMEM16A using electrophysiology and Poisson-Boltzmann calculations..The currents of constitutively active mutants lose their outward rectification as a function of Ca(2+) concentration due to the alleviation of energy barriers for anion conduction Publication Status: Online-Only"
> "Q8BHY3-1","RefSeq","NP_848757.4","30078682","The mAno1 expression is regulated via alternative promoters, and its transcriptional variation results in variation of the N-terminal sequence of the Ano1 protein due to the alternative translation initiation sites."
> "Q8BHY3-1","RefSeq","NP_848757.4","29968377","Https://kdvr.com/2013/06/19/she-gave-elvis-presley-his-first-on- screen-kiss-then-became-a-nun/"
> "Q8BHY3-1","RefSeq","NP_848757.4","18724360","Transmembrane protein 16A (TMEM16A, which we also call anoctamin 1 (ANO1)) is a bona fide Ca(2+)-activated chloride channel that is activated by intracellular Ca(2+) and Ca(2+)-mobilizing stimuli"
> "Q8BHY3-1","RefSeq","NP_848757.4","18585372","Study reports that all mice homozygous for a null allele of Tmem16a died within one month of birth and exhibited severe tracheomalacia with gaps in the tracheal cartilage rings along the entire length of the trachea."
7669a10179,10181
> "Q9R1X5-1","RefSeq","NP_038818.2","26515061","ABCC5 is a general glutamate conjugate and analog transporter that affects the disposition of endogenous metabolites, toxins, and drugs."
> "Q9R1X5-1","RefSeq","NP_038818.2","25922079","Deficiency of MKP5 resulted in increased inflammatory activation in macrophages. These findings thus demonstrate that MKP5 critically controls inflammation in white adipose tissue and the development of metabolic disorders"
> "Q9R1X5-1","RefSeq","NP_038818.2","17589384","Reduced cGMP export as a consequence of decreased MRP5 expression can attenuate heart failure in sepsis."
7672a10185
> "Q62513-1","RefSeq","NP_036111.2","21051538","Pex1 is a novel nuclear effector of ET-1 signaling and may be a regulator of the early stages of cardiac hypertrophy"
7686,7687d10198
< "Q9WV02-1","RefSeq","NP_001160095.1","19403048","These results indicate a major role for SAFB1 in the activation of Srebp-1c through its interaction with RBMX."
< "Q9WV02-1","RefSeq","NP_001160095.1","17188681","RBMX may control SREBP-1c expression in mouse liver in response to high-fructose diet."
7694a10206
> "A2A3V1-1","RefSeq","NP_001075425.1","17302988","The previously undescribed gene Talia is expressed specifically in the distal-most part of the extraembryonic ectoderm, adjacent to the epiblast, and is therefore potential candidates for regulating early patterning events. Publication Status: Online-Only"
7702a10215,10216
> "Q3HNM7-1","RefSeq","NP_776128.2","26694615","Data (including data from studies using embryonic stem cell line) suggest that expression of Insc (inscuteable cell cycle protein) is up-regulated by c-Rel in cell differentiation; minimum transcriptional regulatory element (354 bases) was identified."
> "Q3HNM7-1","RefSeq","NP_776128.2","26440891","Excess mINSC drives symmetric cell division, more stem cells and enhanced mammary outgrowth."
7710d10223
< "Q3U1T9-1","RefSeq","NP_001159973.1","26774822","Dennd1b(-/-) mice were generated and exhibit hyper-allergic responses following antigen challenge. Dennd1b(-/-) TH2, but not other TH cells, exhibit delayed receptor-induced T cell receptor (TCR) downmodulation, enhanced TCR signaling, and increased production of effector cytokines."
7712a10226,10231
> "Q05BC3-1","RefSeq","NP_001273276.1","29229923","Low Eml1 expression is associated with subcortical band heterotopia. Publication Status: Online-Only"
> "Q05BC3-1","RefSeq","NP_001273276.1","24859200","Eml1 knockdown mimicked the HeCo progenitor phenotype and reexpression rescued it"
> "Q9D4G9-1","RefSeq","NP_083180.3","23900276","Results demonstrate the importance of RMI1 in maintaining genome integrity and normal embryonic development"
> "Q9D4G9-1","RefSeq","NP_083180.3","21432623","Glucose regulates RMI1 expression through the E2F pathways in adipose cells."
> "Q9D4G9-1","RefSeq","NP_083180.3","21229605","These results demonstrated a dual-role of RMI1 in embryonic development and tumor suppression."
> "Q9D4G9-1","RefSeq","NP_083180.3","20050919","Results suggest that the regulation of energy balance by RMI1 is attributable to the regulation of food intake and E2F8 expression in adipose tissue."
7714,7717d10232
< "Q4FZC9-1","RefSeq","NP_001036164.1","23761073","Nesprin-3 is critical for the localization of plectin to the nuclear perimeter of Sertoli cells."
< "Q4FZC9-1","RefSeq","NP_001036164.1","23336069","Data indicate roles for linkers of nucleus to cytoskeleton (LINC) molecules nesprin2giant and nesprin3, which anchor actin cap fibers to the nucleus."
< "Q4FZC9-1","RefSeq","NP_001036164.1","17881500","Data support a model in which the actin cytoskeleton influences the binding of plectin dimers to dimers of nesprin-3alpha, which in turn are retained at the nuclear envelope through an interaction with Sun proteins."
< "Q4FZC9-1","RefSeq","NP_001036164.1","16330710","Plectin binds to the integrin alpha6beta4 at the cell surface and to nesprin-3 at the ONM in keratinocytes."
7745a10261,10272
> "Q8K2Z4-1","RefSeq","NP_666283.1","25474630","Condensins I and II have overlapping and non-overlapping functions in Neural stem cells. Publication Status: Online-Only"
> "Q8K2Z4-1","RefSeq","NP_666283.1","23531880","Knock-down of a condensin subunit protein or YY1 reduced rearrangement of Igkappa Vkappa genes suggesting a direct role for YY1-condensin complexes in Igkappa locus structure and rearrangement."
> "Q8K2Z4-1","RefSeq","NP_666283.1","21858164","Data show that that DNA repear process is dictated by PARP1 through its interaction with the chromosome-targeting domain of the hCAP-D2 subunit of condensin I."
> "Q8K2Z4-1","RefSeq","NP_666283.1","16144839","The characterization of two novel E2F target genes, chromosome condensation-related SMC-associated protein 1 (Cnap1) and maternal embryonic leucine zipper kinase (Melk) is reported."
> "Q5XJV7-1","RefSeq","NP_766593.1","30655503","A specific subpopulation of fetal Setd5(+/-) cortical neurons showed altered gene expression of neurodevelopment-related genes. Setd5(+/-) animals manifested several autism-like behaviors, including hyperactivity, cognitive deficit, and altered social interactions. Anatomical differences were observed in Setd5(+/-) adult brains, accompanied by a deficit of deep-layer cortical neurons in the developing brain. Publication Status: Online-Only"
> "Q5XJV7-1","RefSeq","NP_766593.1","30455454","Setd5-haploinsufficient mice present abnormal brain-to-body weight ratios and neural crest defect-associated phenotypes. Setd5-mutant mice show impairments in cognitive tasks, enhanced LTP, delayed ontogenetic profile of ultrasonic vocalization, and behavioral inflexibility. Behavioral issues are accompanied by abnormal expression of postsynaptic density proteins previously associated with cognition."
> "Q5XJV7-1","RefSeq","NP_766593.1","29180574","Both SetD5 and BRD2 bind to the transcription start site and to upstream promoter regions of the Sema3a locus and BRD2 is necessary for the regulation of Sema3A expression by SetD5. Publication Status: Online-Only"
> "Q9EQR6-1","RefSeq","NP_444311.1","21968513","Hematopoietic stem cells of Fancg-/- mice Impaired functionality and homing."
> "Q9EQR6-1","RefSeq","NP_444311.1","22036606","Null mutations in Fanca or Fancg are fully epistatic"
> "Q9EQR6-1","RefSeq","NP_444311.1","21209924","The FA pathway (FancG) is not involved in regulating the outcome of SHM in mammals and it appears dispensable for class switch recombination Publication Status: Online-Only"
> "Q9EQR6-1","RefSeq","NP_444311.1","11918676","Characterization and expression of the murine Fanconi anaemia gene product"
> "Q9EQR6-1","RefSeq","NP_444311.1","11823446","Mice deficient in Fancg were not anemic, but showed hypogonadism, impaired fertility, and hypersensitivity to mitomycin C"
7746a10274
> "Q8CC21-1","RefSeq","NP_083980.2","28673544","UQCRFS1 produces N-terminal polypeptides, which remain bound to holocomplex III. We show that, in normal conditions, these UQCRFS1 fragments are rapidly removed, but when TTC19 is absent they accumulate within complex III, causing its structural and functional impairment."
7749a10278
> "Q8VEJ3-1","RefSeq","NP_663567.1","17397822","Dkk4 acts in a negative feedback loop to attenuate canonical Wnt signaling and may facilitate a switch to the non-canonical Wnt planar cell polarity pathway that is involved in cell movements during morphogenesis."
7750a10280,10291
> "Q91V09-1","RefSeq","NP_080413.2","30369599","Wdr13(-/0) mice exhibited higher serum insulin levels, better glucose clearance and significantly higher number of proliferating beta-cells; reiterating the finding that absence of WDR13 helps in beta-cell hyper-proliferation and recovery from diabetes Publication Status: Online-Only"
> "Q91V09-1","RefSeq","NP_080413.2","28222755","Results provide evidence that WDR13 is a novel transcriptional activator of AP1 target genes in the presence of JNK signal. The lack of Wdr13 gene conferred protection to a large extent against colitis-induced colorectal tumor in mice through reduced expression of AP1 target genes. Publication Status: Online-Only"
> "Q91V09-1","RefSeq","NP_080413.2","26306915","Using two types of heterozygous females carrying either maternally and paternally derived mutant Wdr13 allele we provide genetic evidence that development of placenta determines body weight of mice for the entire life. Publication Status: Online-Only"
> "Q91V09-1","RefSeq","NP_080413.2","22715406","WDR13 is a novel negative regulator of the pancreatic beta cell proliferation."
> "Q91V09-1","RefSeq","NP_080413.2","16094675","WDR13 is localized to the locus XA1.1 and is predominantly expressed in the testis."
> "O08707-1","RefSeq","NP_067622.2","30448408","CKR2 is important in limiting persistent inflammation, tubular loss, and renal fibrosis after ischemic acute kidney injury and, thus, can prevent progression to chronic renal disease."
> "O08707-1","RefSeq","NP_067622.2","30158126","This study shows that Ackr2 constrains NK cell migratory activity and promotes metastasis"
> "O08707-1","RefSeq","NP_067622.2","29469612","ACKR2 controls the CC chemokine expression that drives the influx of CCR2(+) and CCR5(+) IFNgamma-producing gammadeltaT cells, tuning the Th17 response that mediated pulmonary fibrosis triggered by bleomycin instillation."
> "O08707-1","RefSeq","NP_067622.2","29589840","Data indicate that ACKR2 may have a protective role during sepsis, and the absence of ACKR2 leads to exacerbated chemokine accumulation, neutrophil infiltration, and damage to vital organs."
> "O08707-1","RefSeq","NP_067622.2","15750596","The chemokine receptor D6 limits the inflammatory response in vivo."
> "O08707-1","RefSeq","NP_067622.2","14744993","CCR9-deficient IgA+ plasma cells show reduced migration into the small intestine compared with wild-type controls."
> "O08707-1","RefSeq","NP_067622.2","14581607","CCR10 engagement by locally produced CCL27 allows melanoma cells to escape host immune antitumor killing mechanisms (possibly through activation of PI3K/Akt), thereby providing a means for tumor progression"
7754a10296
> "Q91YP6-1","RefSeq","NP_659166.1","22177965","The data demonstrate the ability of the SH3 domain of DOCK180 to interact with ELMO1, regardless of the presence of the polyproline-containing C-terminal end."
7763d10304
< "F2Z472-1","RefSeq","NP_067338.2","15582586","Report the gene duplication of SVS III in both mouse and rat."
7768a10310
> "Q64516-3","RefSeq","NP_997609.1","19546021","GK may have an apoptotic moonlighting role that is lost in glycerol kinase deficiency."
7769a10312,10313
> "Q9EQH7-1","RefSeq","NP_112463.2","29688404","An essential role for Heparin sulfate proteoglycan sulfation via NDST1,2,3 in modulating signal transduction during mouse implantation."
> "Q9EQH7-1","RefSeq","NP_112463.2","18385133","NDST3 function is not essential for development or adult homeostasis despite contributing to HS synthesis in a region-specific manner Erratum:[J Biol Chem. 2008 Aug 15;283(33):22884]"
7772a10317,10319
> "Q99MB1-1","RefSeq","NP_569054.2","30670552","TLR3(-/-) and TRIF(-/-) mice presented higher parasite burdens, increased inflammatory lesions, and reduced production of interleukin 12p40, tumor necrosis factor, gamma interferon, and nitric oxide. Publication Status: Online-Only"
> "Q99MB1-1","RefSeq","NP_569054.2","12202403","Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines"
> "Q99MB1-1","RefSeq","NP_569054.2","11923871","Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4."
7773a10321
> "Q8BXQ2-1","RefSeq","NP_598540.2","16516892","Different regulations of NDAP expression by neurotrophins indicate that the expression of NDAP might be a checkpoint for apoptosis during neuronal development [NDAP]"
7776a10325
> "P84086-1","RefSeq","NP_034076.1","30044227","We describe a high degree of structural similarity between the CpxII CTD and the SNAP25-SN1 domain (C-terminal half) and show that the CTD peptide lowers the rate of SDS-resistant SNARE complex formation in vitro. Moreover, corresponding CpxII:SNAP25 chimeras do restore complexin's function and even 'superclamp' tonic secretion. Publication Status: Online-Only"
7782a10332,10336
> "Q91UZ1-1","RefSeq","NP_038857.1","30188893","Thrombosis suppression by heterozygous Plcb4 loss of function was confirmed through analysis of an independent, CRISPR/Cas9-induced Plcb4 mutation in transgenic mice. Publication Status: Online-Only"
> "Q91UZ1-1","RefSeq","NP_038857.1","27998287","The results of our study showed that thalamic mGluR1-PLCbeta4 pathway was critical in controlling sleep architecture. Publication Status: Online-Only"
> "Q8QZY4-1","RefSeq","NP_659178.1","29079576","Retbindin ablation causes a retinal phenotype characterized by time- and dose-dependent declines in rod and cone photoreceptor functions as early as 120 days of age. Whereas minor retinal ultrastructural defects were observed at all ages examined, a significant decline occurred in photoreceptor nuclei at 240 days of age ( approximately 36.8% rods and approximately 19.9% cones)."
> "Q8QZY4-1","RefSeq","NP_659178.1","26427470","Data suggest Retbindin as a possible flavin binding protein in the neural retina."
> "Q8QZY4-1","RefSeq","NP_659178.1","25542898","Retbindin is an excellent candidate for binding retinal flavins and possibly participating in their transport from the extracellular space to the photoreceptors."
7786,7792d10339
< "Q60668-1","RefSeq","NP_001070733.1","30429285","In this study, AUF1, was posttranslationally destabilized to bring about activation of BMP signaling and wound healing during Candida albicans infection"
< "Q60668-1","RefSeq","NP_001070733.1","30418981","Study identified RANKL and BCL6 mRNA as targets of AUF1 p42. Detailed analysis of 3'UTRs revealed for both that full instability required two elements, which are conserved in evolution. In RANKL mRNA both elements are AU-rich and separated by 30 bases, while in BCL6 mRNA one is AU-rich and 60 bases from a non-AU-rich element that potentially forms a stem-loop structure. Publication Status: Online-Only"
< "Q60668-1","RefSeq","NP_001070733.1","27784781","These results suggest that the post-transcriptional regulation of ATX expression by HuR and AUF1 modulates cancer cell migration."
< "Q60668-1","RefSeq","NP_001070733.1","27452471","Control of ARE-mRNA decay by AUF1 represents a mechanism for adult stem cell regulation."
< "Q60668-1","RefSeq","NP_001070733.1","24891619","MEF2C is a key effector of the myogenesis program promoted by AUF1."
< "Q60668-1","RefSeq","NP_001070733.1","14715706","AUF1 p40, HuR, and the 3'UTR of the CTR mRNA transcript could be involved in posttranscriptional regulation of CTR mRNA expression."
< "Q60668-1","RefSeq","NP_001070733.1","12107167","Interaction with lactate dehydrogenase"
7807a10355,10357
> "Q3TTA7-1","RefSeq","NP_001028410.1","30349541","Study suggests that Cbl-b limits autoimmunity by preventing the pathogenic effects of GM-CSF overproduction in T cells Publication Status: Online-Only"
> "Q3TTA7-1","RefSeq","NP_001028410.1","30054317","CBLB impedes the effector CD8(+) T cell responses in a cell-intrinsic manner."
> "Q3TTA7-1","RefSeq","NP_001028410.1","11826757","Novel E3 ubiquitin-protein ligase; role in regulation of immune response - review Review article"
7821a10372,10375
> "O35716-1","RefSeq","NP_034026.1","30816678","Study reveals that SOCS-1 is implicated in a TF network regulating the expression of central transcription factors like PPAR-gamma and NUR77 thereby influencing the expression of CX3CR1 and CSF1R that are known to be pivotal for the survival of Ly6C(low) monocytes."
> "O35716-1","RefSeq","NP_034026.1","30577275","MiR-155 aggravates liverischemia/reperfusion injury in vivo and hepatocyte hypoxia/reoxygenation injury by suppressing the expression of SOCS1"
> "O35716-1","RefSeq","NP_034026.1","30181351","These findings demonstrated that SOCS1 inhibits nitric oxide (NO) production to establish mycobacterial infection. Publication Status: Online-Only"
> "O35716-1","RefSeq","NP_034026.1","30214448","This study emphasizes the pivotal role of the SOCS1/STAT1 axis in the regulation of inflammation in mesangial proliferative glomerulonephritis Publication Status: Online-Only"
7823,7824c10377,10380
< "Q99PV8-1","RefSeq","NP_001073352.1","12717433","Bcl11b is a key regulator of both differentiation and survival during thymocyte development."
< "Q99PV8-1","RefSeq","NP_001073352.1","12565905","These results indicate that loss-of-function mutations of Rit1 contribute to mouse lymphomagenesis and possibly to human cancer development."
---
> "F8VPJ6-1","RefSeq","NP_001028708.1","29967452","This study shows that Rfx7 is a novel transcriptional regulator of NK cell homeostasis and metabolic quiescence"
> "Q9CPT0-1","RefSeq","NP_080054.1","25180634","CD3/CD28-inducible MNSFbeta-Bcl-G complex may be involved in the regulation of T cell function and survival."
> "Q9CPT0-1","RefSeq","NP_080054.1","23059823","The Bcl-G interacts specifically with proteins of the transport particle protein complex. Publication Status: Online-Only"
> "Q9CPT0-1","RefSeq","NP_080054.1","22914326","Bcl-G is expressed highly in mature spermatids in the testis, CD8(+) conventional dendritic cells (DCs) in hematopoietic tissues and diverse epithelial cell types, including those lining the gastrointestinal and respiratory tracts. Publication Status: Online-Only"
7841,7848c10397,10403
< "Q8R1G1-1","RefSeq","NP_001153112.1","30573454","Upon loss of taspase1, MLL1 association with chromatin is markedly increased due to the stabilization of its unprocessed version, and this stabilization of the uncleaved MLL1 can result in the displacement of MLL chimeras from chromatin in leukemic cells"
< "Q8R1G1-1","RefSeq","NP_001153112.1","25664857","TFIIA is the principal TASP1 substrate that orchestrates craniofacial morphogenesis."
< "Q8R1G1-1","RefSeq","NP_001153112.1","25267403","Taspase1 deficiency disrupts the expression of cyclins and proliferation of HER2+ breast cancer cells."
< "Q8R1G1-1","RefSeq","NP_001153112.1","24176642","Taspase1 cleaves a ubiquitously expressed GTF (TFIIA) to enable tissue-specific (testis) transcription, meeting the demand for sophisticated regulation of distinct subsets of genes in higher organisms."
< "Q8R1G1-1","RefSeq","NP_001153112.1","18395097","TASP1, EPS15R, and PRPF3 expression were significantly induced in HCCs of transgenic EGF2B mice as was P2 promoter-driven HNF4alpha"
< "Q8R1G1-1","RefSeq","NP_001153112.1","16951254","This paper describes the quintessential function of Taspase1 in orchestrating cell cycle progression."
< "Q8BGB7-1","RefSeq","NP_001156507.1","24236849","Our result suggests a significant role for enoph1 and polyamines in anxiety and depression-related behaviors."
< "Q8BGB7-1","RefSeq","NP_001156507.1","19139748","Both single-nucleotide polymorphisms were significantly associated with locomotion-independent trait anxiety, further supporting a functional role of EP for this phenotype."
---
> "Q80VJ2-1","RefSeq","NP_079567.2","26536203","Visfatin upregulated CD36 and SRA expression and downregulated ABCA1 and ABCG1 expression, subsequently increased ox-LDL uptake and decreased cholesterol efflux, and finally promoted foam cell formation via the PI3K- and ERK-dependent pathways."
> "Q80VJ2-1","RefSeq","NP_079567.2","25481196","The results of this study demonstrated that SRA could attenuate microglia mediated inflammation injury in ICH. In addition, SRA mediated negative feedback mechanism in neuroimmune homeostasis."
> "Q80VJ2-1","RefSeq","NP_079567.2","24675075","These data are the first to indicate a functional role for SRA in adipose tissue biology and glucose homeostasis in vivo."
> "Q80VJ2-1","RefSeq","NP_079567.2","15327771","Results identify a pseudouridine synthase, mPus1p, as a coactivator for retinoic acid receptor (mRAR)gamma when coexpressed with steroid receptor RNA activator."
> "Q80VJ2-1","RefSeq","NP_079567.2","14517287","Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo"
> "Q8BSN3-1","RefSeq","NP_084215.2","24067530","Ccdc151 expression is strongly induced during in vitro differentiation of motile cilia of ependymal cells."
> "Q8BSN3-1","RefSeq","NP_084215.2","17971504","C330001K17Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
7849a10405,10410
> "Q2TL60-1","RefSeq","NP_001020099.1","26383633","Results demonstrated that Mipu1 regulated CD36 expression and lipid uptake, and identified a functional Mipu1-response element (MRE) in the mouse CD36 promoter during oxLDL stimulation in RAW264.7 cells."
> "P52785-1","RefSeq","NP_032218.2","30422870","This study showeg that the 2 guanylyl cyclase isoforms NO-GC1 and NO-GC2 are distinctly expressed in neuronal subpopulations of the spinal dorsal horn and in non-neuronal cells of DRG."
> "O35144-1","RefSeq","NP_001273129.1","30450584","Mammary glands lacking TRF2 expression exhibited increased telomere DNA damage response, histopathological and functional degeneration, and prominent ductal fibrosis. TRF2-deficient mammary tumors exhibited rapid onset and increased proliferation."
> "O35144-1","RefSeq","NP_001273129.1","30208292","This review focuses on the current knowledge of shelterin-mediated telomere protection, highlights differences between human and mouse shelterin, and discusses some of the questions that remain Review article"
> "O35144-1","RefSeq","NP_001273129.1","29550946","It plays a role in hematopoietic stem cell regulation and in the maintenance of the HSC pool and the development of hematological disorders. Review article"
> "O35144-1","RefSeq","NP_001273129.1","28805810","The authors propose that TRF2 masks and stabilizes the t-loop three-way junction, thereby protecting telomeres from detrimental deletions and PARP1 activation."
7855a10417,10419
> "Q9WUK6-1","RefSeq","NP_038943.3","28506232","Findings demonstrate functional interplay between a transcriptional regulator and p27(kip1) to mediate neuroprogenitor cell cycle exit, as well as to promote radial migration through a molecular mechanism consistent with suppression of RhoA signaling. Erratum:[Neural Dev. 2018 Jan 11;13(1):1. PMID: 29325591] Publication Status: Online-Only"
> "Q9WUK6-1","RefSeq","NP_038943.3","18262495","Interestingly, co-transfection with simiRP58 and RP58 induced changes in the localization patterns of both proteins."
> "Q9WUK6-1","RefSeq","NP_038943.3","17447250","These results suggest that RP58 plays a crucial role in neuronal proliferation, migration, and differentiation in the developing cerebral cortex."
7857,7861c10421
< "Q9ES97-1","RefSeq","NP_001003934.1","29716941","RTN3 has roles in inducing obesity and hypertriglyceridemia via interactions with heat shock protein family A (Hsp70) member 5, which then increases sterol regulatory element-binding protein 1c and AMP-activated kinase activity."
< "Q9ES97-1","RefSeq","NP_001003934.1","28238655","RTN3 expression is a mediator of RBM3-induced neuroprotection, controlled by novel mechanisms of escape from translational inhibition on cooling."
< "Q9ES97-1","RefSeq","NP_001003934.1","15946766","Since other reports have shown that RTN4-A inhibits neuronal outgrowth and restricts the plasticity of the central nervous system, we speculate that RTN3-A1 might play certain roles in the central nervous system."
< "Q9ES97-1","RefSeq","NP_001003934.1","15350194","RTN3 isoforms may contribute, by as yet unknown mechanisms, to neuronal survival and plasticity"
< "Q9ES97-1","RefSeq","NP_001003934.1","11990451","CDNA of mouse reticulon 3 (mRTN3) was cloned. The gene was mapped at band B of chromosome 19."
---
> "P70270-1","RefSeq","NP_033041.3","26876210","Our study highlights the importance of the cooperation between Rad54 and Mus81 for mediating DNA DSB repair and restraining chromosome missegregation."
7866a10427,10428
> "Q8R035-1","RefSeq","NP_081005.1","27029019","Because ICT1 is essential in human cells, these results suggest that ribosome rescue activity in mitochondria is required in humans Publication Status: Online-Only"
> "Q8R035-1","RefSeq","NP_081005.1","20869366","Solution structure of the catalytic domain of the ICT1 protein that lacks an N-terminal mitochondrial targeting signal and an unstructured C-terminal basic-residue-rich extension"
7889a10452,10457
> "Q91V88-1","RefSeq","NP_277060.2","28842827","Low Nephronectin expression is associated with Metastatic Breast Carcinoma."
> "Q91V88-1","RefSeq","NP_277060.2","29335243","Nephronectin is produced by podocytes and deposited into the GBM. It colocalized with alpha8beta1 integrin to novel, specialized adhesion structures at sites of mesangial cell protrusion at the base of the capillary loops. Nephronectin loss disrupted these structures, mislocalizating alpha8beta1, and caused mesangial sclerosis."
> "Q91V88-1","RefSeq","NP_277060.2","28345658","Results show that Npnt is highly expressed in tooth germ, and localized in the basement membrane between dental epithelium and mesenchyme. The study indicates that Npnt plays a critical scaffold role in dental epithelial stem cell differentiation and proliferation, and regulates Sox2 expression during tooth development. Publication Status: Online-Only"
> "Q91V88-1","RefSeq","NP_277060.2","17537792","Results thus place nephronectin and alpha8beta1 integrin in a pathway that regulates Gdnf expression and is essential for kidney development"
> "Q61205-1","RefSeq","NP_032802.1","29853524","In vivo RNAi screening identifies Pafah1b3 as a target for combination therapy with TKIs in BCR-ABL1(+) BCP-ALL."
> "Q61205-1","RefSeq","NP_032802.1","19541372","These observations support the further development of PMS-601 as an adjunctive therapy for HIV-1 associated neurocognitive disorders."
7896a10465,10470
> "Q9EPB7-1","RefSeq","NP_071872.1","29580570","Gpr88 deletion disrupts executive, reward, and emotional networks in a configuration that reduces alcohol reward and promotes alcohol seeking and drinking. The functional connectivity signature is reminiscent of alterations observed in individuals at risk for Alcohol use disorder. Erratum:[Biol Psychiatry. 2018 Dec 1;84(11):857. PMID: 30409267]"
> "Q9EPB7-1","RefSeq","NP_071872.1","29110094","The data of this study suggested that primary sensory perception (olfaction and vision) is intact, but the loss of Gpr88 contributes to delayed behavioral responses that require sensory processing."
> "Q9EPB7-1","RefSeq","NP_071872.1","28882062","GPR88 activity shapes the mouse brain functional and structural connectome"
> "Q9EPB7-1","RefSeq","NP_071872.1","23064379","This study demonistrated that lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors"
> "Q9EPB7-1","RefSeq","NP_071872.1","19796684","The modulatory role of Gpr88 in striatal dopamine function suggests it may be a new target for treatments for psychiatric disorders."
> "Q920C1-1","RefSeq","NP_112548.2","30344043","Study identified that astrocyte-secreted chordin-like 1 (Chrdl1) is necessary and sufficient to induce mature GluA2-containing synapses to form."
7911a10486
> "Q6P3A8-1","RefSeq","NP_954665.1","16875466","Disruption of the BDK gene establishes that regulation of BCKDH by phosphorylation is critically important for the regulation of oxidative disposal of branched-chain amino acids."
7919a10495,10498
> "Q8BYR8-1","RefSeq","NP_796362.1","15809054","SLC41A2 is a Mg2+ transporter that might be involved in magnesium homeostasis in epithelial cells Erratum:[Biochem Biophys Res Commun. 2007 May 11;356(3):822]"
> "G3XA57-1","RefSeq","NP_001157839.1","20534835","Data demonstrate that AMPH leads to an increase of NET in endosomes of single boutons and varicosities in a Rab11-dependent manner."
> "G3XA57-1","RefSeq","NP_001157839.1","12364336","Rab11-FIP2 has a role in the coupling of receptor-mediated endocytosis to the subsequent sorting of receptor-containing vesicles in endosomes [RAB11-FIP2]"
> "Q3URY0-1","RefSeq","NP_001028967.2","26402067","Sirh11/Zcchc16 is the first SIRH gene to be involved in brain function, instead of just the placenta, as seen in the case of Peg10, Peg11/Rtl1 and Sirh7/Ldoc1 Publication Status: Online-Only"
7923a10503,10504
> "Q9D3R6-1","RefSeq","NP_081997.1","29136647","Authors present data suggesting that depending on context, KATNAL2 can partner with the regulatory protein KATNB1 or act autonomously. Data indicate KATNAL2 may regulate delta- and epsilon-tubulin rather than classical alpha-beta-tubulin microtubule polymers, suggesting the katanin family has a greater diversity of function than previously realised. Publication Status: Online-Only"
> "Q9D3R6-1","RefSeq","NP_081997.1","26153462","KATNAL2 isoforms interact with themselves, with each other and with Nubp1 and Nubp2."
7924a10506,10508
> "Q8R139-1","RefSeq","NP_666369.1","23255610","PMAT is a major transporter for choroid plexus uptake of bioactive amines and xenobiotic cations."
> "Q8R139-1","RefSeq","NP_666369.1","16873718","ENT4, in addition to playing roles in cardiac serotonin transport, contributes to the regulation of extracellular adenosine concentrations, in particular under the acidotic conditions associated with ischemia."
> "P97431-1","RefSeq","NP_058547.2","29913133","This study shows that IRF6 and AP2A interaction regulates epidermal development"
7931a10516
> "O35681-1","RefSeq","NP_057872.3","27399837","The combined inactivation of all 3 E-Syt genes has no effect on mouse viability or fertility."
7932a10518,10520
> "Q80YQ2-1","RefSeq","NP_081623.3","30250136","Study identifies Med23 as an essential transcriptional regulator that controls invariant natural killer T-cells differentiation and terminal maturation. Publication Status: Online-Only"
> "Q80YQ2-1","RefSeq","NP_081623.3","30218073","Findings identify Med23 as a gatekeeper of myeloid potential of HSCs, thus providing unique insights into the relationship among Med23-mediated transcriptional regulations, the myeloid potential of HSCs and HSC activation upon stresses. Publication Status: Online-Only"
> "Q80YQ2-1","RefSeq","NP_081623.3","27033977","MED23 constitutes a molecular node in the regulatory network of anabolic bone formation and related diseases. Publication Status: Online-Only"
7940a10529,10538
> "Q07076-1","RefSeq","NP_033804.2","29783989","AnnexinA7 positively regulates expression levels of SDF1/CXCR4 Publication Status: Online-Only"
> "Q07076-1","RefSeq","NP_033804.2","28176245","Study demonstrates that annexin A7 protein has an important role in gastric cancer. Silencing the expression of ANXA7 in vitro and in vivo induces the apoptosis of BGC823 gastric cancer cells and, importantly, inhibits the growth of tumor xenografts in mice."
> "Q07076-1","RefSeq","NP_033804.2","27914826","Ezrin may play a role in regulating lymphatic metastasis in hepatocellular carcinoma and might be inversely associated with A7 expression."
> "Q07076-1","RefSeq","NP_033804.2","27871077","Annexin A7 deficiency upregulates FGF23 plasma levels, an effect paralleled by increased corticosterone plasma levels, as well as decreased 1,25(OH)2 D3 and PTH plasma levels."
> "Q8R2G6-1","RefSeq","NP_080715.2","30439364","Here, we showed that CCDC80 inhibited ERK1/2 activation, decreased TET2 expression and TET2-mediated DNA demethylation, and then promoted DNA methylation of the LPL gene. Consequently, CCDC80 reduced LPL expression and activity, leading to increased plasma TG levels and enhanced atherosclerotic lesions area, which at least partially involved FOXO3a."
> "Q8R2G6-1","RefSeq","NP_080715.2","29901779","The results demonstrate DRO1 to be a strong tumor suppressor in the chemically induced colon carcinogenic mouse model. Additionally, DRO1 inhibits colitis-associated colon cancer formation and plays a putative role for in inflammatory bowel disease."
> "Q8R2G6-1","RefSeq","NP_080715.2","27645901","DRO1 is a crucial regulator of energy homeostasis in vivo and functions as an inhibitor of adipogenesis in primary cells."
> "Q8R2G6-1","RefSeq","NP_080715.2","25497869","Data indicate that embryonic fibroblasts from cl2/coiled-coil domain-containing protein 80 (ccdc80) knock-out mice showed higher proliferation rate and lower susceptibility to apoptosis."
> "Q8R2G6-1","RefSeq","NP_080715.2","18178152","In conclusion, the expression pattern of URB suggests its role in obesity and the results suggest that URB is secreted, at least in part, from adipocytes."
> "Q8R2G6-1","RefSeq","NP_080715.2","15325258","Downregulated during osteoblastic differentiation of bone marrow stromal cells.  Suggests role in skeletogenesis."
7942,7943d10539
< "Q9JLV2-1","RefSeq","NP_001156924.1","29704259","Hepatocyte TRUSS promotes pathological stimuli-induced non alcoholic fatty liver disease and metabolic disorders, through activation of NF-kappaB by promoting ubiquitination and degradation of IkappaBalpha"
< "Q9JLV2-1","RefSeq","NP_001156924.1","14585990","Cloning and characterization of tumor necrosis factor receptor 1 (TNF-R1)-associated ubiquitous scaffolding and signaling protein (TRUSS)"
7944a10541,10544
> "P39688-1","RefSeq","NP_032080.2","30658076","MiR-125a-3p exerts anti-fibrotic effects in silica-induced pulmonary fibrosis by regulating Fyn/STAT3 signaling."
> "P39688-1","RefSeq","NP_032080.2","29661967","Our results suggest that Fyn-mediated regulation of the cell-cell adhesion of neuroblasts is critical for their detachment from chains in the postnatal brain"
> "P39688-1","RefSeq","NP_032080.2","29353218","These results suggest that Nrf2 plays a central role in the prevention of Ang II-induced cardiomyopathy, and SFN prevents Ang II-induced cardiomyopathy partially via the Akt/GSK-3beta/Fyn-mediated Nrf2 activation."
> "P39688-1","RefSeq","NP_032080.2","29180007","These results suggested that Fyn has a regulatory role in iNOS expression in astrocytes during neuroinflammatory responses."
7945a10546,10551
> "Q8C570-1","RefSeq","NP_780321.1","28276625","Surface NKG2D ligand RAE1epsilon on tumour cells induces CD11b(+) Gr-1(+) myeloid-derived suppressor cell (MDSC) via NKG2D in vitro and in vivo."
> "Q8C570-1","RefSeq","NP_780321.1","27477692","High RAE1 expression is associated with lymphoma."
> "Q8C570-1","RefSeq","NP_780321.1","27874833","The authors observed that the mouse cytomegalovirus encoded protein m18 is necessary and sufficient to drive expression of the RAE-1 family of NKG2D ligands. RAE-1 is transcriptionally repressed by histone deacetylase inhibitor 3 (HDAC3) in healthy cells, and m18 relieves this repression by directly interacting with Casein Kinase II and preventing it from activating HDAC3. Publication Status: Online-Only"
> "Q8C570-1","RefSeq","NP_780321.1","25583577","An increased expression of the NKG2D ligand MICA in systemic lupus erthematosus (SLE) patients' kidneys and Rae-1 and Mult-1 in various murine SLE models, is reported."
> "Q8C570-1","RefSeq","NP_780321.1","16355229","Results suggest that Rae1 and Nup98 are temporal regulators of APC(Cdh1) that maintain euploidy by preventing unscheduled degradation of securin"
> "Q8C570-1","RefSeq","NP_780321.1","15629720","VSV M protein blocks mRNA export by disrupting Rae1 function, which can be reverted by induction of Rae1 expression."
7946a10553,10557
> "Q01965-1","RefSeq","NP_032560.2","28980301","The authors show that Ly9 influences Invariant natural killer T cell lineage differentiation.  Furthermore, treatment of wild-type mice with an agonistic monoclonal antibody directed against Ly9 impaired IL-4 and IFN-gamma production and reduced by half the number of spleen iNKT cells, with a significant decrease in the proportion of NKT2 cells."
> "Q01965-1","RefSeq","NP_032560.2","24376606","SLAMF3 is an inhibitor of hepatocellular carcinoma cell proliferation and tumor progression. Publication Status: Online-Only"
> "Q8R1P5-1","RefSeq","NP_666149.1","29290552","THIK-1 is the main K(+) channel expressed in microglia in situ. THIK-1 is tonically active, and its activity is potentiated by P2Y12 receptors. Microglial immune surveillance and cytokine release require THIK-1 channel activity."
> "Q8R1P5-1","RefSeq","NP_666149.1","27566292","Dysregulation of a potassium channel, THIK-1, targeted by caspase-8, accelerates cell shrinkage."
> "Q8R1P5-1","RefSeq","NP_666149.1","18209473","THIK-1 and THIK-2 are abundantly expressed in the proximal and distal nephron of the mammalian kidney."
7952,7953c10563
< "P27512-1","RefSeq","NP_035741.2","30096208","We here show that loss of macrophage CD40 signaling does not affect obesity induced metabolic dysregulation and indicates that CD40-deficiency on other cell-types than the macrophage is responsible for the metabolic dysregulation, adipose tissue inflammation and hepatosteatosis that are observed in CD40-/- mice. Publication Status: Online-Only"
< "P27512-1","RefSeq","NP_035741.2","29452567","These novel findings suggest that the mechanisms that underlie Ang-II-dependent thrombotic and inflammatory responses link to the signaling of CD40L via both CD40 and VLA5."
---
> "Q8R1E9-1","RefSeq","NP_001263404.1","29771985","ABP subunit BG27 shares phylogenetic relationships with Fel d 1 chains. Publication Status: Online-Only"
7955,7957c10565,10567
< "C0LLJ0-1","RefSeq","NP_001013796.2","28189564","A decreased H7N9 influenza A virus polymerase activity when importin-alpha7 was silenced by siRNA, is reported."
< "C0LLJ0-1","RefSeq","NP_001013796.2","20699224","Knocking out of Kpna7 induced abnormalities of gene expression (dppa2, dppa4, and piwil2) and epigenetic modifications (down-regulation of histone H3K27me3). Biochemical analysis showed that KPNA7 interacts with KPNB1 (importin-beta1)."
< "C0LLJ0-1","RefSeq","NP_001013796.2","20701745","A novel importin alpha family member with distinct subcellular localization and nuclear localization signal binding characteristics Publication Status: Online-Only"
---
> "Q8CI59-1","RefSeq","NP_573449.2","25515317","TSAP6 deficiency results in abnormal erythroid maturation and leads to microcytic anemia."
> "Q8CI59-1","RefSeq","NP_573449.2","22689674","Steap3 deficiency causes abnormal iron status and homeostasis, which leads to impaired TLR4-mediated inflammatory responses in macrophages."
> "Q8CI59-1","RefSeq","NP_573449.2","12606722","TSAP6 may augment Myt1 activity and act downstream to p53 to interface apoptosis and cell-cycle progression"
7961a10572,10574
> "Q7TQA1-1","RefSeq","NP_899179.1","28686733","Contrary to earlier predictions, neither the murine nor rat IGSF1-2 is secreted from heterologous or homologous cells. In addition, neither protein associates with the plasma membrane. Rather, IGSF1-2 appears to be retained in the endoplasmic reticulum. Publication Status: Online-Only"
> "Q7TQA1-1","RefSeq","NP_899179.1","28324000","Igsf1-deficient males exhibit normal serum TSH levels as well as normal numbers of TSH-expressing thyrotropes. However, pituitary expression of the TSH subunit genes and TSH protein content are reduced, as is expression of the receptor for thyrotropin-releasing hormone (TRH"
> "Q00417-1","RefSeq","NP_033357.1","30420627","TCF-1 both enhances HEB protein stability and functionally cooperates with HEB in defining the epigenetic and transcriptional status of CD4(+)CD8(+) thymocytes"
7962a10576,10581
> "Q8K209-1","RefSeq","NP_061370.2","29855662","Collagen III protected beta-cells from cytokine-induced apoptosis, triggered increases in [Ca(2+)]i and potentiated glucose-induced insulin secretion from WT islets but not from Gpr56(-/-) islets. Deletion of GPR56 did not affect glucose-induced insulin secretion in vitro and it did not impair glucose tolerance in adult mice"
> "Q8K209-1","RefSeq","NP_061370.2","29809138","Microglial transglutaminase-2 drives myelination and myelin repair via ADGRG1 in oligodendrocyte precursor cells. Publication Status: Online-Only"
> "Q8K209-1","RefSeq","NP_061370.2","29367382","Gpr56 as a new regulator in the development and maintenance of peripheral myelin."
> "Q8K209-1","RefSeq","NP_061370.2","29225194","All hematopoietic stem cells (HSCs) in mouse bone marrow mononuclear cells express GPR56 protein on their surface and that GPR56 is a positive marker for HSCs."
> "Q8K209-1","RefSeq","NP_061370.2","28380450","Deletion of G-protein coupled receptor 56 (GPR56) in the mouse germline abrogated progastrin-dependent colonic mucosal proliferation and increased apoptosis."
> "Q8K209-1","RefSeq","NP_061370.2","15044805","Preferential expression in neuronal progenitor cells of the cerebral cortical ventricular and subventricular zones duing periods of neurogenesis"
7970a10590,10593
> "Q01887-1","RefSeq","NP_038677.3","29180410","Smek1 and Smek2 (Smek1/2) are key factors in the Ryk signaling pathway"
> "Q01887-1","RefSeq","NP_038677.3","28729735","These findings reveal an essential role for Ryk in regulating dendrite complexity. Publication Status: Online-Only"
> "Q01887-1","RefSeq","NP_038677.3","27882948","Ryk deficiency in hematopoietic stem cells from fetal liver reduces their quiescence, leading to proliferation-induced apoptosis and decreased self-renewal. Publication Status: Online-Only"
> "Q62092-1","RefSeq","NP_035072.2","28299779","We show that NEEP21/Nsg1 and P19/Nsg2 are present in both overlapping and distinct cell populations in the hippocampus, neocortex, and cerebellum during development."
7977d10599
< "P11416-1","RefSeq","NP_001170773.1","30650370","This study shows that RAR-alpha represses a Th9 transcriptional and epigenomic program to reduce allergic pathology"
7983a10606,10612
> "P42337-1","RefSeq","NP_032865.2","31336140","Present study highlighted that overexpression of miR-203 may function as a cardioprotective regulator in DCM by targeting PIK3CA via inactivation of PI3K/Akt signaling pathway."
> "P42337-1","RefSeq","NP_032865.2","30905780","High Pik3ca expression is associated with abdominal aortic aneurysm."
> "P42337-1","RefSeq","NP_032865.2","30627910","The major role in stimulation of the synthesis of granulocytic CSF during stressful stimulation is played by PI3K/Akt signaling cascade."
> "Q9JMH6-1","RefSeq","NP_056577.2","30805084","TXNRD1 inhibition augments hyperoxia-induced glutathione-dependent antioxidant responses in neonatal mice. Publication Status: Online-Only"
> "Q9JMH6-1","RefSeq","NP_056577.2","29749372","Study in transgenic mice finds that T-cell activation is linked to a drastic downregulation of Txnip and an increase in Txn1/Txnrd1 expression, which is absolutely required for synthesis of 2'-deoxyribonucleotides during T-cell metabolic reprogramming. Txnrd1 is critical for expansion of the activated T-cell population during viral and parasite infection. Publication Status: Online-Only"
> "Q9JMH6-1","RefSeq","NP_056577.2","28775321","We have identified a novel molecular axis which functionally acts in skeletal muscle myogenesis through the modulation of the antioxidant enzyme TrxR1 by miR-23 Publication Status: Online-Only"
> "Q9JMH6-1","RefSeq","NP_056577.2","28686716","GSR is not essential for the maintenance of antioxidant defenses in mouse cochlea; the thioredoxin/thioredoxin reductase system can probably operate as a functional backup for GSR. Publication Status: Online-Only"
7992,7994c10621,10623
< "P49446-1","RefSeq","NP_001303608.1","25381250","GRB2 physically links cyt-PTPe with Src and enables cyt-PTPe to activate Src downstream of activated integrins in osteoclast-like cells."
< "P49446-1","RefSeq","NP_001303608.1","24694598","PTPs alpha and epsilon play distinct roles in osteoclasts."
< "P49446-1","RefSeq","NP_001303608.1","22722941","Multifaceted modulation of K+ channels by protein-tyrosine phosphatase epsilon tunes neuronal excitability."
---
> "Q8K3I9-1","RefSeq","NP_573499.2","28744915","These findings suggest that Glcci1 is a new marker of a subpopulation of lateral ganglionic eminence ventricular zone progenitor cells in the Gsx2 lineage."
> "Q8BG05-1","RefSeq","NP_932758.1","22546510","Characterization of hnRNP A3 in human and mouse cell lines"
> "Q8BG05-1","RefSeq","NP_932758.1","20885981","HnRNP A3 is a major liver nuclear protein binding to age related increase element of the factor IX gene. Publication Status: Online-Only"
7997a10627,10629
> "Q3KNY5-1","RefSeq","NP_079782.1","17971504","2310007A19Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
> "P12400-1","RefSeq","NP_031823.1","28759565","CTLA-2 secretion is induced by dendritic cells to enhance regulatory T cell conversion after administration of cholera toxin and cAMP Publication Status: Online-Only"
> "P12400-1","RefSeq","NP_031823.1","14681235","Expression of CTLA-2beta in the decidua may regulate implantation of the embryo by neutralizing the activities of one or more proteases generated by the proliferating trophoblast"
8012,8017c10644,10646
< "Q9Z148-1","RefSeq","NP_665829.1","30455462","Epidermis-specific deletion of G9a histone methyltransferase (G9a) results in higher chromatin accessibility without major morphological alterations."
< "Q9Z148-1","RefSeq","NP_665829.1","29720423","G9a facilitates maintenance of cellular identity of CD8 T cells."
< "Q9Z148-1","RefSeq","NP_665829.1","29745895","The authors show that G9a accumulates typically at 4 to 8 cell stage to promote timely repression of a subset of 4 cell stage-specific genes. Loss of maternal inheritance of G9a disrupts the gene regulatory network resulting in developmental delay and destabilisation of inner cell mass lineages by the late blastocyst stage. Publication Status: Online-Only"
< "Q9Z148-1","RefSeq","NP_665829.1","29774081","G9a exerts oncogenic effects in colorectal cancer by increasing Plk1 expression.  G9a dimethylated p53 at lysine 373, which in turn increased Plk1 expression and promoted CRC cell growth. Publication Status: Online-Only"
< "Q9Z148-1","RefSeq","NP_665829.1","12586828","Expression of Snrpn, an imprinted gene regulated by the Prader-Willi syndrome imprinting center is biallelic in G9a -/- ES cells, indicating loss of imprinting, and demonstrating a role of G9a in CpG methylation of PWS-IC."
< "Q9Z148-1","RefSeq","NP_665829.1","12130538","Results indicate that euchromatic Histone H3 lysine 9 (H3-K9) methylation regulated by G9a is essential for early embryogenesis and is involved in the transcriptional repression of developmental genes."
---
> "Q61550-1","RefSeq","NP_033035.3","29217590","The results demonstrate that the zygotic genome folds into loops and domains that critically depend on Scc1-cohesin and that are regulated in size and linear density by Wapl."
> "Q61550-1","RefSeq","NP_033035.3","28863138","N keratinocytes, the promoter-enhancer anchoring regions in the gene-rich transcriptionally active TADs are enriched for the binding of chromatin architectural proteins CTCF, Rad21 and chromatin remodeler Brg1. In contrast to gene-rich TADs, gene-poor TADs show preferential spatial contacts with each other, do not contain active enhancers and show decreased binding of CTCF, Rad21 and Brg1 in keratinocytes Publication Status: Online-Only"
> "Q61550-1","RefSeq","NP_033035.3","27554164","The cohesin complex regulates PRC2 targeting to silence Hoxa7 and Hoxa9 and negatively regulate self-renewal. Our studies identify a novel epigenetic mechanism underlying leukemogenesis in AML patients with cohesin mutations."
8018a10648,10650
> "P27811-1","RefSeq","NP_034867.3","30995786","Nkrp1 isoforms c1, c2 and f were expressed prevalently as homodimers, whereas the Nkrp1a displays larger proportion of monomers on the cell surface. Publication Status: Online-Only"
> "P27811-1","RefSeq","NP_034867.3","27238500","Solution structure of the lymphocyte receptor Nkrp1a reveals a distinct conformation of the long loop region as compared to in the crystal structure."
> "P27811-1","RefSeq","NP_034867.3","22139156","Structure of the H107R variant of the extracellular domain of the mouse natural killer cell receptor NKR-P1A has been determined by X-ray diffraction at 2.3 A resolution from a merohedrally twinned crystal"
8021,8023c10653,10655
< "Q3UDK1-1","RefSeq","NP_001156942.1","25992615","TRAFD1, in association with Plekhm1/Rab7-positive late endosomes-early lysosomes, has a previously unknown role in vesicle trafficking, acidification, and resorption in osteoclasts Publication Status: Online-Only"
< "Q3UDK1-1","RefSeq","NP_001156942.1","18849341","FLN29, in addition to playing a negative regulatory role in the TLR4 signaling pathway, negatively regulates the RIG-I-like helicase signaling pathway at the level of IPS-1/TRAF6 and IPS-1/TRAF3 complexes"
< "Q3UDK1-1","RefSeq","NP_001156942.1","16221674","FLN29 is a new negative feedback regulator of TLR signaling"
---
> "Q62009-1","RefSeq","NP_056599.1","30332313","Periostin stimulates signaling pathways involved in an abnormal tissue repair process that contributes to cyst growth and fibrosis polycystic kidney disease."
> "Q62009-1","RefSeq","NP_056599.1","30222134","Findings show that Schwann cells promote macrophage infiltration by upregulating Postn and suggest that POSTN is a novel target for the treatment of macrophage-associated inflammatory neuropathies."
> "Q62009-1","RefSeq","NP_056599.1","12213217","Human cancer cell lines with reduced endogenous periostin gene expression that were infected with a recombinant rat periostin gene had reduced anchorage-independent growth"
8031a10664,10665
> "Q8BX43-1","RefSeq","NP_796047.2","30138536","Findings suggest that RELT acts as a negative regulator that controls the early phase of T-cell activation probably by promoting T-cell apoptosis."
> "Q8BLQ9-1","RefSeq","NP_848836.2","29217450","Cadm2 expression regulates body weight and glucose homeostasis."
8041a10676,10679
> "Q8BPU7-1","RefSeq","NP_932761.1","30643265","Loss of the engulfment signaling protein Elmo1 alleviated disease severity in mouse models of arthritis through Elmo1's regulation of neutrophil recruitment to inflamed joints."
> "Q8BPU7-1","RefSeq","NP_932761.1","30219846","ELMO1 protects against DSS-induced colonic injury in mice through its effect on epithelial migration via Rac1 activation."
> "Q8BPU7-1","RefSeq","NP_932761.1","29029244","ELMO1 is present in the phagosome and enhances bacterial clearance by differential regulation of lysosomal acidification and enzymatic activity."
> "Q8BPU7-1","RefSeq","NP_932761.1","28219480","The authors identify ELMO1 as a novel target of TGFbeta signaling and show that restoration of Tgfbr2 results in a complete block of ELMO1 in vivo. Knocking down Elmo1 impairs metastasis of carcinoma cells to the lung, thereby providing insights into the mechanisms of progression of Tgfbr2-deficient invasive transition zone squamous cell carcinoma. Publication Status: Online-Only"
8052a10691,10693
> "P97300-2","RefSeq","NP_033171.2","29974341","Findings suggest that ablation of Np65 influences gene expression, which may contribute to abnormal brain development; these results provide clues to the mechanisms underlying the altered brain functions of Np65-deficient mice"
> "P97300-2","RefSeq","NP_033171.2","29056295","Results establish neuroplastin and basigin as obligatory auxiliary subunits of native Plasma Membrane Calcium Atpases and key regulators of intracellular Ca2+ concentration."
> "P97300-2","RefSeq","NP_033171.2","28779130","These results indicate that epilation induces McSCs activation through EDN3/EDNRB signaling and in turn leads to skin and hair hyperpigmentation. The findings suggest that EDN/EDNRB signaling may serve as a potential therapeutic target to promote repigmentation in hypopigmentation disorders. Publication Status: Online-Only"
8063a10705,10711
> "Q5QNS5-1","RefSeq","NP_599009.2","29595914","Our findings suggest a role for UMOD-dependent inhibition of KIM-1 expression and its apoptotic cell scavenging responses during chronic obstruction-associated tubular injury"
> "Q5QNS5-1","RefSeq","NP_599009.2","29074644","By preventing ERK1/2 phosphorylation following renal injury, STAT3 phosphorylation is decreased, leading to less phosphorylated STAT3 within the nucleus, and subsequently less KIM-1 mRNA increases post injury"
> "Q5QNS5-1","RefSeq","NP_599009.2","28978444","Study used a previously described highly mobile membrane mimetic membrane in combination with a conventional lipid bilayer model to generate a membrane-bound configuration of Tim1 in silico, identified two possible states for a membrane-bound form of Tim1."
> "Q5QNS5-1","RefSeq","NP_599009.2","28951472","Findings provide evidence for the role of Tim-1 in the induction of a cytokine storm phenomenon and the pathogenesis of Ebola virus disease Publication Status: Online-Only"
> "Q5QNS5-1","RefSeq","NP_599009.2","15793576","TIM-1-TIM-4 interaction is involved in regulating T cell proliferation"
> "Q5QNS5-1","RefSeq","NP_599009.2","15793575","TIM-1 is a molecule that costimulates T cell activation"
> "Q5QNS5-1","RefSeq","NP_599009.2","14534576","Protective effects of hepatitis A virus on atopic disease depends on a common TIM-1 allele"
8070a10719,10723
> "O35930-1","RefSeq","NP_034456.2","29794068","A 2- to 3-fold decrease occurred in circulating TPO in GPIbalpha(-/-) mice compared with wild-type. Lower TPO levels in GPIbalpha-/- mice are due to impaired platelet-stimulated hepatic TPO production. The N terminus of GPIbalpha is required for platelet-mediated hepatic TPO generation."
> "O35930-1","RefSeq","NP_034456.2","28555620","Leukocyte Mac-1 and platelet GPIbalpha are involved in thrombosis Erratum:[Nat Commun. 2017 Jul 04;8:16124. PMID: 28675156] Publication Status: Online-Only"
> "Q99PP7-1","RefSeq","NP_444400.2","29930104","Trim33 promotes the proinflammatory function of Th17 cells by inducing IL-17 and suppressing IL-10 expression."
> "Q99PP7-1","RefSeq","NP_444400.2","28844090","Data show that tripartite motif 33 (TRIM33) mediates Wnt signaling by directly regulating the expression of a specific subset of Wnt target genes."
> "Q99PP7-1","RefSeq","NP_444400.2","28724755","Trim33 is thus revealed as being essential for the navigation of macrophages and neutrophils towards developmental or inflammatory cues within vertebrate tissues."
8072a10726,10729
> "Q62052-1","RefSeq","NP_068679.1","28009282","These results suggest that impairment in GABRB3 downregulates OCA2 and indirectly causes ocular hypopigmentation and visual defects in Angelman syndrome (AS) and Prader-Willi syndrome"
> "Q62052-1","RefSeq","NP_068679.1","26971330","Standard chromatin immunoprecipitation and reporter assays suggest that TBX2 represses Oca2 at least in part directly. Hence, the results suggest that TBX2 may act as a nexus linking cell proliferation and melanogenesis"
> "A1Y9I9-1","RefSeq","NP_001269017.1","28504928","These studies thus suggest functional diversification between mCOMT and mTOMT, where mTOMT is critical for the assembly of the mechanotransduction machinery of hair cells. Erratum:[Elife. 2017 Nov 08;6:. PMID: 29116042] Publication Status: Online-Only"
> "A1Y9I9-1","RefSeq","NP_001269017.1","18794526","Mice homozygous for a missense mutation in Comt2 show vestibular impairment, profound sensorineuronal deafness, and progressive degeneration of the organ of Corti"
8075,8076c10732,10736
< "Q8CBY1-1","RefSeq","NP_001032298.1","24799716","Samd4 has a role in leanness, myopathy, uncoupled mitochondrial respiration, and regulation of mTORC1 signaling"
< "Q8CBY1-1","RefSeq","NP_001032298.1","16221671","Smaug 1 has a role in RNA granule formation and translation regulation in neurons"
---
> "Q71M36-1","RefSeq","NP_038912.3","24265546","Despite the previously reported upregulation of Cspg5 during retinal degeneration in Rpe65/ mice, no protective effect or any involvement of Cspg5 in disease progression was identified. Publication Status: Online-Only"
> "Q71M36-1","RefSeq","NP_038912.3","23889129","CALEB is transiently required for synapse maturation in the cerebellum."
> "Q71M36-1","RefSeq","NP_038912.3","11929867","Phosphorylation and localization in lipid rafts"
> "P35582-1","RefSeq","NP_032285.2","30475207","FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer. Publication Status: Online-Only"
> "P35582-1","RefSeq","NP_032285.2","30061015","Foxa1 and Foxa2 in thymic epithelial cells (TEC) regulate medullary TEC and regulatory T-cell maturation."
8077a10738,10739
> "Q9R1S8-1","RefSeq","NP_033926.1","29459744","Overexpression of CAPN7 in Ishikawa cells or in the uterus of mice inhibited embryo implantation in vitro and in vivo. Publication Status: Online-Only"
> "Q9R1S8-1","RefSeq","NP_033926.1","14981075","Calpain-derived Htt fragmentation has a role in Huntington's disease and aberrant activation of calpains may play a role in HD pathogenesis"
8081a10744,10747
> "P47743-1","RefSeq","NP_001298001.1","23664812","The data of this study revealed very different roles for mGlu8 in amygdala synaptic transmission, fear learning and its expression"
> "P47743-1","RefSeq","NP_001298001.1","23220400","In the dentate gyrus of mGluR8 receptor-deficient mice, effects from selective agonists are linked to the lateral and medial perforant pathway."
> "P47743-1","RefSeq","NP_001298001.1","12213279","Naive mGlu8 receptor-deficient mice show increased anxiety-related behavior in the elevated plus maze in low illumination conditions (red light) compared to wild-type mice."
> "P47743-1","RefSeq","NP_001298001.1","12213278","The role of mGluR8 as a presynaptic autoreceptor and its contribution to cognitive processes are hypothesized and the utility of gene targeting is discussed as compared to pharmacological methods."
8086a10753,10754
> "Q80YX1-1","RefSeq","NP_035737.2","31408364","Upregulation of tenascin C mRNA was observed with overexpression of Sox4, suggesting a causal relationship between the two events in mammary gland Involution."
> "Q80YX1-1","RefSeq","NP_035737.2","30629639","Study confirmed that the HNK-1 epitope was primarily expressed on TNC in the embryonic day 16 mouse brain and promoted neurite outgrowth. That this signal was mediated by CNTN, which is an HNK-1-expressing neuronal receptor. These results suggest that the HNK-1 epitope is a key modifier of TNC and CNTN in the regulation of embryonic brain development. Publication Status: Online-Only"
8090,8092d10757
< "Q7TNK1-1","RefSeq","NP_001020089.1","29298325","Provide a novel conditional KO animal model in which to investigate the downstream genes directly and/or indirectly regulated by RFX4 isoform 1. This model could provide new insights into the pathogenesis of obstructive hydrocephalus and holoprosencephaly in humans, both relatively common and disabling birth defects Publication Status: Online-Only"
< "Q7TNK1-1","RefSeq","NP_001020089.1","14701801","Mouse regulatory factor X4 transcript is expressed in the suprachiasmatic nucleus and regulated by light"
< "Q7TNK1-1","RefSeq","NP_001020089.1","12925582","Data implicate the RFX4_v3 variant transcript as being crucial for early brain development, as well as for the genesis of the subcommissural organ."
8102,8108c10767,10769
< "Q80YV2-1","RefSeq","NP_001298015.1","22955283","Data show that cell cycle-dependent phosphorylation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA)is mediated by extracellular signal-regulated kinase 2 (ERK2)."
< "Q80YV2-1","RefSeq","NP_001298015.1","22696294","Results reveal a novel role for NIPA in meiosis."
< "Q80YV2-1","RefSeq","NP_001298015.1","22205987","Phosphorylated NIPA is degraded in late mitosis in an APC/C(Cdh1)-dependent manner"
< "Q80YV2-1","RefSeq","NP_001298015.1","12748172","NIPA has an antiapoptotic role in NPM-ALK-mediated signaling events"
< "P58283-1","RefSeq","NP_542128.2","27995769","Missense mutations in TRIAD3 abolished the interaction of TRIAD3A with Arc, disrupting Arc ubiquitination, and consequently Arc degradation."
< "P58283-1","RefSeq","NP_542128.2","28154178","Low RNF216 expression is associated with obesity-induced inflammation."
< "P58283-1","RefSeq","NP_542128.2","25484083","Identifies a novel negative regulator of autophagy and suggests that RNF216 may be a target for treatment of inflammatory diseases"
---
> "Q6GU68-1","RefSeq","NP_036173.1","30510196","Immunoglobulin superfamily containing leucine-rich repeat protein (Islr) interacts with Dishevelled-2 (Dvl2) to activate canonical Wnt signaling. Publication Status: Online-Only"
> "Q6GU68-1","RefSeq","NP_036173.1","26924503","Those results are consistent with a decrease in the number of clonogenic colony-forming unit-fibroblasts within the BM of Meflin-deficient mice. These preliminary data suggest that Meflin is a potential marker for cultured MSCs and their source cells in vivo. Publication Status: Online-Only"
> "A2BED8-1","RefSeq","NP_084312.1","22075566","These results suggest that SAMT1 proteins are physiological substrates of MARCH11 and are delivered to lysosomes through the TGN-MVB pathway by a ubiquitin-dependent sorting system in mouse spermatids."
8117,8121c10778,10787
< "Q7TMK9-1","RefSeq","NP_062640.2","28436985","SYNCRIP is required to maintain myeloid leukemia survival."
< "Q7TMK9-1","RefSeq","NP_062640.2","27732855","SYNCRIP (synaptotagmin-binding cytoplasmic RNA-interacting protein; also known as hnRNP-Q or NSAP1) is a component of the hepatocyte exosomal miRNA sorting machinery."
< "Q7TMK9-1","RefSeq","NP_062640.2","27392095","HnRNP Q binds to mCry1 mRNA via the 5'UTR. Furthermore, hnRNP Q inhibits the translation of mCry1 mRNA, leading to altered rhythmicity in the mCRY1 protein profile. Publication Status: Online-Only"
< "Q7TMK9-1","RefSeq","NP_062640.2","26658614","HnRNP-Q1-mediated repression of Gap-43 mRNA translation provides an additional mechanism for regulating GAP-43 expression and function and may be critical for neuronal development."
< "Q7TMK9-1","RefSeq","NP_062640.2","11994298","Identification of the tyrosine phosphorylated form"
---
> "Q8BZN4-1","RefSeq","NP_083054.1","30446657","Using liver cancer as a model, NUAK2 was identified as an essential mediator of YAP-driven hepatomegaly and tumorigenesis in vivo. Publication Status: Online-Only"
> "Q8BZN4-1","RefSeq","NP_083054.1","29298809","Data (including data from studies in knockout and transgenic mice) suggest that Nuak2/Snark is involved in both adipose inflammation and energy metabolism in white/brown adipocytes; Nuak2/Snark appears to regulate thermogenesis in brown adipocytes."
> "Q8BZN4-1","RefSeq","NP_083054.1","26690705","These findings reveal a critical role for SNARK in myocyte survival and the maintenance of muscle mass with age."
> "Q8BZN4-1","RefSeq","NP_083054.1","20713714","Data show that SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle."
> "Q8BZN4-1","RefSeq","NP_083054.1","18307533","Obesity was a risk factor for colorectal tumorigenesis in Snark(+/-) mice model."
> "Q2TBA3-1","RefSeq","NP_766421.1","31092922","Results demonstrate that partial disruption of the CBM complex and induction of IFNgamma secretion in the preferentially self-reactive Treg cell pool does not cause systemic autoimmunity but is sufficient to prime the tumour environment for successful immune checkpoint therapy"
> "Q2TBA3-1","RefSeq","NP_766421.1","31138793","CARD11-BCL10-MALT1 (CBM) signaling mediates TCR-induced NF-kappaB activation in Tregs and controls the conversion of resting Tregs to effector Tregs under homeostatic conditions. However, in inflammatory milieus, cytokines can bypass the CBM requirement for this differentiation step. Publication Status: Online-Only"
> "Q2TBA3-1","RefSeq","NP_766421.1","30564895","Malt1 protease activity plays an important role in the production of IL-17 in the blood and colon upon T cell receptor stimulation. In addition, Malt1 protease inactivation attenuates the development of experimental colitis with the regulation of the population of Th17 and Th1/17 cells."
> "Q2TBA3-1","RefSeq","NP_766421.1","30375474","This strategy resulted in the design of a peptide-based fluorogenic substrate, which exhibited significant activity toward MALT1. Publication Status: Online-Only"
> "Q2TBA3-1","RefSeq","NP_766421.1","14576442","Findings demonstrate that primary T and B lymphocytes from paracaspase (MALT1)-deficient mice are defective in antigen-receptor-induced NF-kappaB activation, cytokine production, and proliferation"
8125a10792,10795
> "Q9CUU3-1","RefSeq","NP_796165.2","28150150","Using yeast two-hybrid screening, it discovered the surprising finding that the SYCP2 NTR associates well with the centromere. It was reported that the C-terminal region of mSYCP2 was found to be responsible for the association of SYCP3 and SYCP1 for synaptonemal complex (SC) formation."
> "Q9CUU3-1","RefSeq","NP_796165.2","15870106","SYCP2 are not required for centromere cohesion at the metaphase-I stage in male germ cells."
> "Q9CUU3-1","RefSeq","NP_796165.2","15237206","SYCP2 and SYCP3 proteins function in the specificity of chromatin attachment to the chromosome core"
> "Q9CQ94-1","RefSeq","NP_079765.3","20338151","The enrichment of CSP-beta in synaptosomes and the association of CSP-beta with synaptic vesicles suggest that CSP-beta, like CSP-alpha, may be an important component of the regulated secretory machinery in mouse brain"
8133a10804,10807
> "Q80TY4-1","RefSeq","NP_776293.1","27859418","ST18 expression in epithelial cells is induced by tumor-associated macrophages, contributing to the reciprocal feed-forward loop between both cell types in liver tumorigenesis."
> "Q80TY4-1","RefSeq","NP_776293.1","27195679","Myt3 suppression sensitizes islet cells to high glucose-induced cell death via Bim induction. Publication Status: Online-Only"
> "Q80TY4-1","RefSeq","NP_776293.1","26177052","The data suggest a model by which cytokine-induced Myt3 suppression leads to Tgfbi de-repression and subsequently to impaired islet-cell migration, revealing a novel role for Myt3 in regulating islet-cell migration."
> "Q80TY4-1","RefSeq","NP_776293.1","16920096","Myt1, Myt3, and Ngn3 are induced by Mfng and have roles in Mfng-mediated repression of Notch signaling which could serve as a trigger for endocrine islet differentiation [Myt3]"
8153a10828,10832
> "Q8C6P8-1","RefSeq","NP_001161974.1","28476430","A group of functionally significant composite DNA elements (ZFP57 binding site (ZFBS)-Morph overlaps) that may play dual roles in the regulation of allele-specific gene expression."
> "Q8C6P8-1","RefSeq","NP_001161974.1","27257070","Another function of ZFP57 in early embryogenesis is to repress cis-acting regulatory elements whose activity is not yet required."
> "Q8C6P8-1","RefSeq","NP_001161974.1","26481358","Data show that ZFP57 binding is affected by single nucleotide polymorphism (SNPs) and closely associated TGCCGC motif sequences that are present at the target sites."
> "Q8C6P8-1","RefSeq","NP_001161974.1","26025256","Within established mouse imprinted clusters, ZFP57 specifically binds known or predicted imprinting control region elements, but does not interact with secondary somatically differentially methylated regions (DMRs) or germline DMRs that are not imprinting controlling. Publication Status: Online-Only"
> "Q8C6P8-1","RefSeq","NP_001161974.1","18854139","Zpf57 maintains both maternal and paternal genomic imprints."
8163a10843
> "P48302-1","RefSeq","NP_031930.1","29570803","ET-1 injection into the TG promotes ETAR/ETBR-mediated facial heat hyperalgesia, and both receptors are clearly implicated in Constriction of infraorbital Nerve-induced hyperalgesia in the murine Trigeminal system."
8180a10861,10870
> "Q6PKN7-1","RefSeq","NP_998894.1","25525809","Results showed that absence of Inca1 mildly affects normal hematopoiesis under homeostatic conditions but controls hematopoiesis after induction of cytotoxic stress and plays a role in the maintenance of leukemia development in acute myeloid leukemia. Publication Status: Online-Only"
> "Q6PKN7-1","RefSeq","NP_998894.1","21540187","Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling"
> "Q68G58-1","RefSeq","NP_084219.1","25158232","Expression of Apex 2 in chondrocytes appears to be associated with the degeneration of articular cartilage in osteoarthritis. Publication Status: Online-Only"
> "Q68G58-1","RefSeq","NP_084219.1","24935922","Results indicate a role for apurinic/apyrimidinic endonuclease (APE) 2 (Apex2) in the protection of germinal center (GC) cells from activation-induced cytidine deaminase (AID)-independent damage."
> "Q68G58-1","RefSeq","NP_084219.1","24927551","Data provide new insight into error-prone repair of AID-induced lesions, which we propose is facilitated by down-regulation of APE1 and up-regulation of APE2 expression in germinal center B cells."
> "Q68G58-1","RefSeq","NP_084219.1","19556307","Apex2 is required for efficient somatic hypermutation of immunoglobulin genes."
> "Q68G58-1","RefSeq","NP_084219.1","18585982","The present study clearly demonstrates that APEX2-null lymphocytes have a higher frequency of DNA breaks, indicating that APEX2 may play an important role(s) during their generation and/or repair."
> "Q68G58-1","RefSeq","NP_084219.1","18025127","Both APE1 and APE2 function in antibody switch recomibination, resulting in double stranded breaks necesary for this recombination. Erratum:[J Exp Med. 2007 Dec 24;204(13):3295]"
> "Q68G58-1","RefSeq","NP_084219.1","15319281","APEX2 is required for proper cell cycle progression of proliferating lymphocytes."
> "Q68G58-1","RefSeq","NP_084219.1","12573260","May participate in postreplicative base excision repair"
8193a10884,10886
> "P70689-1","RefSeq","NP_001258592.1","30464764","These findings suggest that Cx30 deficiency increased ramified microglia in the central nervous system in the naive state and improved chronic experimental autoimmune encephalomyelitis through redirecting microglia toward an anti-inflammatory phenotype, suggesting a hitherto unknown critical role of astrocytic Cx30 in regulating microglial number and functional state Publication Status: Online-Only"
> "P70689-1","RefSeq","NP_001258592.1","30103794","The findings of this study indicated that Cx30 plays critical roles in astrocyte neuroprotection in an MPTP PD model Publication Status: Online-Only"
> "P70689-1","RefSeq","NP_001258592.1","29475972","Connexin 30 controls astroglial polarity during development Publication Status: Online-Only"
8195a10889,10895
> "Q9JJS7-1","RefSeq","NP_065646.1","27855539","These data highlight the P2Y4 receptor as an inhibitor of cardiac fat formation"
> "Q9JJS7-1","RefSeq","NP_065646.1","28322086","In the brain samples, expressions of P2Y4 and P2X7 were significantly reduced, whereas that of P2Y1 was significantly elevated in an age-dependent manner."
> "Q9JJS7-1","RefSeq","NP_065646.1","26972684","Data show that activation of nucleotide receptor P2Y4 (P2Y4) in the differentiating embryonic stem cells (ESCs) resulted in an increased proportion of neurons expressing vesicular glutamate transporter (vGluT)."
> "Q9JJS7-1","RefSeq","NP_065646.1","25595790","Present study defines the P2Y4 nucleotide receptor, expressed on cardiac microvascular endothelial cells and involved in postnatal heart development, as an important regulator of the inflammatory response to cardiac ischemia"
> "Q9JJS7-1","RefSeq","NP_065646.1","24001770","Amyloid beta peptide 1-42 induced self-uptake in microglia through pinocytosis, a process involving activation of P2Y4 receptors by autocrine ATP signaling."
> "Q9JJS7-1","RefSeq","NP_065646.1","12814360","Purinergic receptors on microglial cells: functional expression in acute brain slices and modulation of microglial activation in vitro."
> "Q9JJS7-1","RefSeq","NP_065646.1","12644577","Knock-out mice reveal tissue-specific roles of P2Y receptor subtypes in different epithelia."
8211a10912,10913
> "Q01768-1","RefSeq","NP_032731.1","30411342","Data identify NME2 as one of the two NME isoforms involved in class switch recombination (CSR) in B cells. Its knockdown results in decreased CSR. On the contrary of Nme1; NME2 binds to S regions only after stimulation."
> "Q01768-1","RefSeq","NP_032731.1","27604954","Results demonstrate that nm23 plays a vital role in decidualization in mice and humans and that nm23 gene expression is hormonally regulated."
8227a10930,10931
> "O55042-1","RefSeq","NP_033247.1","30528390","Variations of amyloid fibrillar morphologies among the aggregates of a-syn mutants, mainly categorized into two groups: twisted fibrils observed for both WT and E46K while straight fibrils for the other mutants."
> "O55042-1","RefSeq","NP_033247.1","30503521","Common variation at SNCA might modulate PD risk."
8230,8233d10933
< "Q9D7I0-1","RefSeq","NP_080134.1","18677103","Mouse Scotin induces apoptosis and developmental defects when overexpressed in Drosophila."
< "Q9D7I0-1","RefSeq","NP_080134.1","18164684","We conclude that Scotin is a new p63 target gene induced during epithelial differentiation, a complex process that also involves ER stress induction."
< "Q9D7I0-1","RefSeq","NP_080134.1","17889823","ALG-2 binding to Scotin is strictly calcium dependent, indicating a role of this interaction in calcium signaling pathways"
< "Q9D7I0-1","RefSeq","NP_080134.1","12135983","Scotin plays a role in p53-dependent apoptosis"
8256a10957,10963
> "Q7TNV9-1","RefSeq","NP_898847.1","29723492","Although murine beta-defensin 14 might affect local skin microbial communities, it may further affect other healing parameters. Indeed, exogenously administered murine beta-defensin 14 directly delayed mouse primary keratinocyte scratch wound closure in vitro."
> "Q7TNV9-1","RefSeq","NP_898847.1","29253819","This work demonstrates that mouse beta-defensin-14 can promote the maturation of dendritic cells in which TLR-4 is possibly involved"
> "Q7TNV9-1","RefSeq","NP_898847.1","24489798","This study indicated that the potential antibacterial role of increased MBD-14 in the osteomyelitis mouse model. Publication Status: Online-Only"
> "Q7TNV9-1","RefSeq","NP_898847.1","22504651","BD14 expression by tumor-infiltrating host cells results in chemoattraction of CCR6-positive B220-positive lymphocytes, which in turn initiates a proangiogenic pathway leading to enhanced angiogenesis and organized tumor tissue development."
> "Q7TNV9-1","RefSeq","NP_898847.1","20483750","Beta-defensin 4 and 14 contribute to the innate and adaptive immune response in their role as chemoattractants"
> "Q7TNV9-1","RefSeq","NP_898847.1","18180295","Chemoattractant and antimicrobial activities of beta-defensins can be separated, and both of these functions are independent of intramolecular disulfide bonds"
> "Q7TNV9-1","RefSeq","NP_898847.1","18167348","Both hBD3 and mBD14 were chemotactic for freshly isolated mouse resident peritoneal cells. Thus, mBD14, based on structural and functional similarities, appears to be an orthologue of hBD3."
8260,8261d10966
< "P68404-1","RefSeq","NP_001303601.1","30889825","Phorbol 12-myristate 13-acetate induced PRKCB, improved lipopolysaccharide-tolerance, and attenuated sepsis severity, predominantly in FcGRIIb-/- mice. Publication Status: Online-Only"
< "P68404-1","RefSeq","NP_001303601.1","29744369","Our results suggest that the decrease in the activity of cPKCbetaII and cPKCgamma, especially cPKCgamma, may play key roles in the pathogenesis of diabetic encephalopathy. Publication Status: Online-Only"
8275a10981
> "E9PVZ8-1","RefSeq","NP_084311.1","27226319","Golgb1 has specific functions in protein glycosylation and tissue morphogenesis."
8277c10983
< "P97447-1","RefSeq","NP_001274729.1","30260394","Mutant mice harboring the missense mutation p.W122S in Fhl1 gene developed late-onset cardiac dysfunction without skeletal myopathy"
---
> "Q8BP31-1","RefSeq","NP_780345.1","27506794","RNF122 suppresses antiviral type I interferon production by targeting RIG-I caspase activation and recruitment domains to mediate RIG-I degradation."
8288a10995
> "Q14AW5-1","RefSeq","NP_081878.1","17442852","Sun domain containing protein Nsun7 mutant sperm exhibited depressed progressive motility associated with a rigid flagellar midpiece (but not principal piece) segment"
8292,8294d10998
< "Q9QYB8-1","RefSeq","NP_001258786.1","29032200","Sez6l2 is one of the auxiliary subunits of the AMPA receptor and acts as a scaffolding protein to link GluR1 to ADD. Furthermore, Sez6l2 overexpression upregulates ADD phosphorylation, whereas siRNA-mediated downregulation of Sez612 prevents ADD phosphorylation, suggesting that Sez6l2 modulates AMPA-ADD signal transduction."
< "Q9QYB8-1","RefSeq","NP_001258786.1","27480796","Study shows that a single injection of 3 pharmacologically distinct psychoactive drugs can modify spines in the nucleus accumbens within a day. beta-adducin is necessary for these effects. Study suggests that fine regulation of DARPP-32 phosphorylation is a major factor in mediating common effects on beta-adducin of various drugs with distinct or even opposite modes of action."
< "Q9QYB8-1","RefSeq","NP_001258786.1","15728854","Beta-Adducin may play an important role in the cellular mechanisms underlying activity-dependent synaptic plasticity associated with learning and memory. Erratum:[J Neurosci. 2005 Apr 6;25(14):1 p following 3627]"
8295a11000,11004
> "Q9R1Q6-1","RefSeq","NP_075543.1","29466738","Myogenic differentiation is achieved through the specific interaction between Cry2 and Bclaf1, which stabilizes mRNAs encoding cyclin D1, a G1/S phase transition regulator, and Tmem176b, a transmembrane regulator for myogenic cell fusion."
> "Q9R1Q6-1","RefSeq","NP_075543.1","27009467","Study characterized Tmem176a and b expression in RORgamma t+ lymphocytes at transcriptional and protein levels and present evidence that both genes exert a redundant ion channel function related to a colocalisation in close proximity to the Golgi apparatus. Publication Status: Online-Only"
> "Q6DIC0-1","RefSeq","NP_035546.2","30522882","In both mouse keratinocytes and HaCaT cells, Brm deficiency led to an increased cell population growth following ultraviolet radiation (UVR) exposure compared to cells with normal levels of Brm. The loss of Brm in keratinocytes exposed to UVR enables them to resume proliferation while harboring DNA photolesions, leading to an increased fixation of mutations and, consequently, increased carcinogenesis."
> "Q6DIC0-1","RefSeq","NP_035546.2","29087303","PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors."
> "Q6DIC0-1","RefSeq","NP_035546.2","28232072","BRG1/BRM and c-MYC have an antagonistic relationship regulating the expression of cardiac conduction genes that maintain contractility, which is reminiscent of their antagonistic roles as a tumor suppressor and oncogene in cancer."
8297,8299c11006,11020
< "P54830-1","RefSeq","NP_001157037.1","29948948","STEP61 undergoes proteolytic degradation in conditions leading to synaptic strengthening and memory formation"
< "P54830-1","RefSeq","NP_001157037.1","30176350","Deletion of STEP has a beneficial effect on motor coordination and cognition in a mouse model of Huntington's disease."
< "P54830-1","RefSeq","NP_001157037.1","29508281","STEP plays an important role at nerve terminals in the regulation of Ca(2+) homeostasis and neurotransmitter release."
---
> "Q61103-1","RefSeq","NP_035392.1","26571505","The role of SMARCA4 and the two SWI/SNF subunits SMARCD2/BAF60B and DPF2/BAF45D in leukaemia, was investigated. Publication Status: Online-Only"
> "Q9ESV0-1","RefSeq","NP_065240.2","24204270","Data provide a new function for DDX24 and help explain innate immune gene regulation, mechanisms that may additionally provide insight into the causes of inflammatory disease."
> "Q8BWG8-1","RefSeq","NP_835738.1","30216111","These results suggest that beta-arr1 promotes liver fibrosis via autophagy-mediated Snail signaling, and beta-arr1 may be a therapeutic target for liver fibrosis."
> "Q8BWG8-1","RefSeq","NP_835738.1","30144357","In our study, we demonstrated here that beta-arr1 plays a crucial protective role in AP via repression of NF-_x04A1;Bp65 activation."
> "Q8BWG8-1","RefSeq","NP_835738.1","30591079","Beta-arrestin 1 mediates beta2-adrenergic receptor-mediated skeletal muscle growth and strength. Publication Status: Online-Only"
> "Q99PN3-1","RefSeq","NP_001273656.1","29203640","Sustained exposure of cells to TGF-beta resulted in recovery from proliferative arrest in association with amplification of the Myc proto-oncogene, with MYC inhibiting TRIM26 induction by TGF-beta. Publication Status: Online-Only"
> "Q99PN3-1","RefSeq","NP_001273656.1","25763818","Our findings delineate a novel mechanism for the termination of IRF3 activation in nucleus through TRIM26-mediated IRF3 ubiquitination and degradation. Publication Status: Online-Only"
> "Q8R2Y8-1","RefSeq","NP_778169.1","28175314","Ptrh2 levels were up-regulated in dystrophin deficient mdx muscle, which correlates with the elevated levels of the a7b1 integrin observed in mdx muscle and Duchenne muscular dystrophy patients. Similar to the a7 integrin, Ptrh2 expression was decreased in laminin-a2 null gastrocnemius muscle"
> "Q8R2Y8-1","RefSeq","NP_778169.1","25770104","These results support an unanticipated yet essential role for Bit-1 in controlling myogenesis through regulation of Bcl-2."
> "Q8R2Y8-1","RefSeq","NP_778169.1","21383007","Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway"
> "Q8R2Y8-1","RefSeq","NP_778169.1","21886829","Downregulation of Bit1 specifically potentiated tumor metastasis in vivo"
> "Q8R2Y8-1","RefSeq","NP_778169.1","18218778","These studies establish the physiological significance of Bit1 activity and begin to delineate a Bit1 signaling pathway that acts through Erk regulation."
> "P40224-2","RefSeq","NP_068350.1","30898705","Study indicated that the up-regulated expression of CXCL12 in IFN-gamma induced abortion mouse uteri was not directly the responding of the administration of IFN-gamma. The up-regulated expression of CXCL12 in the later stage of aborted mouse uteri played an anti-inflammatory role that involves in the process of endometrial restoration after abortion."
> "P40224-2","RefSeq","NP_068350.1","30870116","Concluded that SDF-1/CXCR4 pathway improved diabetic retinopathy possibly by increasing cell viability"
> "O55047-1","RefSeq","NP_001281263.1","28708136","TLK1 and TLK2 have largely redundant roles in genome maintenance."
8311a11033,11037
> "P04768-1","RefSeq","NP_036084.2","19435806","Findings identify a novel role for alpha3beta1 integrin in promoting wound angiogenesis through a mechanism of crosstalk from epidermal to endothelial cells, and they implicate MRP3 in this integrin-dependent crosstalk"
> "P04768-1","RefSeq","NP_036084.2","16876275","Data demonstrate that proliferin (Plf)1, Plf1 minus exon3, Plf2 and Mrp3 but not Mrp4 are expressed in mouse whole brain by diagnostic RT-PCR and Western blotting."
> "P97801-1","RefSeq","NP_035550.1","30327977","The involvement of calpain in survival motor neuron 1 regulation on motor neurons, was examined."
> "P97801-1","RefSeq","NP_035550.1","30137324","To further assess the effects of Spinal muscular atrophy deficiency on the liver, we employed the severe Taiwanese model (Smn1-/-, SMN20/2TG) that has a mean survival of 10 days, with healthy heterozygous littermates (Smn1+/-, SMN20/2TG) as controls"
> "P97801-1","RefSeq","NP_035550.1","30188931","Of the six biomarkers, only COMP and DPP4 showed high and SPP1 moderate correlation with the spinal muscular atrophy phenotype. PLS3 overexpression neither influenced the SMN level nor the six biomarkers, supporting the hypothesis that PLS3 acts as an independent protective modifier. Publication Status: Online-Only"
8326a11053,11055
> "Q99JB0-1","RefSeq","NP_291041.2","28884027","Our findings suggest that KLF7 promotes DPSN axonal plasticity and the formation of synapses with motor neurons at the caudal spinal cord, leading to improved functional recovery"
> "Q99JB0-1","RefSeq","NP_291041.2","26930448","Was upregulated in quiescent satellite cell and nonproliferating myoblasts."
> "Q99JB0-1","RefSeq","NP_291041.2","15937222","Klf7 gene ablation reduces TrkA expression in sensory neurons due to effect on cell death"
8329a11059,11062
> "Q8BT07-1","RefSeq","NP_083036.2","29683733","That Cep55 overexpression causes change in germ cell proportions and manifests as a Sertoli cell only tubule phenotype"
> "Q8BT07-1","RefSeq","NP_083036.2","26582107","Cep55 may act as an MTOC-associated protein regulating spindle organization, and thus cell cycle progression during mouse oocyte meiotic maturation. Publication Status: Online-Only"
> "Q8BT07-1","RefSeq","NP_083036.2","20176808","TEX14 prevents the completion of cytokinesis by altering the destiny of CEP55 from a nidus for abscission to an integral component of the intercellular bridge."
> "Q8BT07-1","RefSeq","NP_083036.2","20186884","The results suggest that Cep55 and pericentrin are required for the stable bridge between germ cells during spermatogenesis and spermiogenesis."
8353a11087,11092
> "Q9DCJ1-1","RefSeq","NP_064372.2","21799304","The crosstalk between AMPK and mTORC1 signaling is a highly regulated way to control changes in muscle growth and metabolic rate imposed by external cues."
> "Q9DCJ1-1","RefSeq","NP_064372.2","16797547","The mutant, Gbeta1(W332A) protein, although inactive, retains its ability to bind Kir3 and prevents the wild type Gbeta from activating the channel."
> "Q8CH72-1","RefSeq","NP_444314.2","28508149","The miRNA activity inhibition function of pathogenic LRRK2 is directly antagonized by the neuronal cell fate determinant TRIM32."
> "Q8CH72-1","RefSeq","NP_444314.2","28514764","TRIM32 is a novel essential positive factor modulating axonal regeneration and the recovery of motor function following SCI, possibly through suppressing proliferation of glial cells."
> "Q8CH72-1","RefSeq","NP_444314.2","28933219","Suppression of Trim32 promotes the recovery of neurological function after traumatic brain injury."
> "Q8CH72-1","RefSeq","NP_444314.2","28954259","TRIM32 as a crucial positive regulator of Herpes Simplex Virus type 1 (HSV-1) induced IFN-beta production in corneal epithelial cells, and it played a predominant role in clearing HSV-1 from the cornea."
8356a11096,11101
> "Q6NWW9-1","RefSeq","NP_775274.2","27521659","MiR-215-5p is a negative regulator of adipocyte differentiation through post-transcriptional regulation of FNDC3B and CTNNBIP1 during early adipogenesis"
> "Q6NWW9-1","RefSeq","NP_775274.2","26948083","Fad104 suppressed anchorage-independent growth of melanoma cells, and the N-terminal region of FAD104 is essential for inhibiting malignant transformation and STAT3 activity"
> "Q6NWW9-1","RefSeq","NP_775274.2","24052261","Down-regulation of Smad1/5/8 phosphorylation by FAD104 is dependent on the N-terminal region of FAD104 and that fad104 functions as a novel negative regulator of BMP/Smad signaling and is required for proper development for calvarial bone."
> "Q6NWW9-1","RefSeq","NP_775274.2","21704616","Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation"
> "Q6NWW9-1","RefSeq","NP_775274.2","20493170","Fad104 reciprocally regulates differentiation of adipocytes and osteoblast; functions as a positive regulator in adipocyte differentiation and as a negative regulator in osteoblast differentiation."
> "Q6NWW9-1","RefSeq","NP_775274.2","19138685","Fad104 is essential for the survival of newborns just after birth and important for cell proliferation, adhesion, spreading and migration."
8363,8366d11107
< "Q8VBV4-2","RefSeq","NP_001171244.1","31278268","Study finds that loss of Fbxw7 enhances the myelinating potential of Schwann cells (SCs). Fbxw7 mutant SCs make thicker myelin sheaths and sometimes appear to myelinate multiple axons in a fashion reminiscent of oligodendrocytes. Taken together, findings show that the restriction of myelinating SCs to myelinate a single axon may be mutable and that Fbxw7 is a critical player in regulating the myelinating potential of SCs. Publication Status: Online-Only"
< "Q8VBV4-2","RefSeq","NP_001171244.1","29633504","Loss of FBXW7 promotes non-small-cell lung cancer progression as well as gefitinib resistance."
< "Q8VBV4-2","RefSeq","NP_001171244.1","29475832","FBXW7 is markedly downregulated in the liver of obese mice. Mechanistically, FBXW7 directly binds to hepatokine fetuin-A to induce its ubiquitination and subsequent proteasomal degradation, comprising an important mechanism maintaining glucose homeostasis."
< "Q8VBV4-2","RefSeq","NP_001171244.1","29550488","Found that Fbw7 loss caused activation of NF-kappaB signaling. Thus, FBW7 plays a protective role in acute intestinal inflammation by modulating the inflammatory response of NF-kappaB pathway."
8369a11111,11114
> "Q9WVG6-1","RefSeq","NP_694781.1","30550788","CARM1 accumulates in nuclear granules at the 2- to 4-cell stage transition in the mouse embryo, with the majority corresponding to paraspeckles. The paraspeckle component Neat1 and its partner p54nrb are required for CARM1's association with paraspeckles and for H3R26 methylation."
> "Q9WVG6-1","RefSeq","NP_694781.1","30391528","Study shows that peripheral nerve injury induced the upregulation of the mRNA and protein expression of coactivator-associated arginine methyltransferase 1 (CARM1) in the injured dorsal root ganglion. Findings suggest that CARM1 may serve as a promising therapeutic target for neuropathic pain treatment in clinical applications."
> "Q9WVG6-1","RefSeq","NP_694781.1","30366907","C9orf72 acts by promoting the lysosomal degradation of coactivator-associated arginine methyltransferase 1 (CARM1), which in turn regulates autophagy-lysosomal functions and lipid metabolism."
> "Q9WVG6-1","RefSeq","NP_694781.1","30153436","Our data demonstrate that CARM1 is required for transcriptional activation of a subset of RA target genes, and we uncover changes in the recruitment of Suz12 and the epigenetic H3K27me3 and H3K27ac marks at gene regulatory regions for CRABP2 and NR2F1 during RA-induced differentiation."
8373a11119,11121
> "Q91XU3-1","RefSeq","NP_473438.1","27313209","PI5P4Kgamma plays a role in the regulation of the immune system via mTORC1 signaling."
> "Q91XU3-1","RefSeq","NP_473438.1","19757494","Our data suggest that PIP4Kgamma may have a role in neuron function, specifically in the regulation of vesicular transport, in specific regions of the developed brain"
> "Q91XU3-1","RefSeq","NP_473438.1","18753295","PIP4Kgamma may have a function in the regulation of vesicular transport in specialized kidney epithelial cells."
8376a11125,11129
> "P69744-1","RefSeq","NP_001007573.1","30916584","This study found that TRPV5 and TRPV6 are involved in calcium transport in the placenta and bone, and therefore play a role in calcium homeostasis during embryonic and fetal development."
> "P69744-1","RefSeq","NP_001007573.1","27102152","Life-long challenge of Ca2+ homeostasis present in Trpv5-/- mice causes accelerated bone aging and a low cortical and trabecular bone mass phenotype"
> "P69744-1","RefSeq","NP_001007573.1","26747426","Beta-gal is present in the pro-urine from where it is thought to stimulate TRPV5 activity."
> "P69744-1","RefSeq","NP_001007573.1","24828496","Phosphorylation of beta1-AR by PKA stimulates active Ca(2+)influx through TRPV5."
> "P69744-1","RefSeq","NP_001007573.1","14679186","The key function of TRPV5 is in active Ca2+ reabsorption and it has an essential role in Ca2+ homeostasis"
8381c11134
< "Q810F8-1","RefSeq","NP_001001320.1","20162674","Data show that the LacZ-marked Tbx10 expressing cells are likely to be a subpopulation of interneurons in the ventral pons."
---
> "Q61983-1","RefSeq","NP_033224.3","20566650","Results strongly suggested that NPT1 is a Cl(-)-dependent polyspecific anion exporter involved in urate excretion under physiological conditions"
8385a11139
> "Q8BYC6-1","RefSeq","NP_899129.2","28068307","This study shows that during positive selection in the spleen, B-cell receptor signaling causes immature type 1 transitional B cells to become receptive to Notch ligands via Taok3-mediated surface expression of ADAM10"
8390a11145,11148
> "Q9Z0Z4-1","RefSeq","NP_851790.1","30060949","Results suggest that ablation of hephaestin and ceruloplasmin could lead to severe systemic iron deficiency and local tissue iron overload, which disrupt the whole body iron homeostasis and impact on tissue functions"
> "Q9Z0Z4-1","RefSeq","NP_851790.1","29883959","We thus used hephaestin (Heph) and ceruloplasmin (Cp) single-knockout mice and Heph/Cp double-knockout mice to investigate the roles of multicopper ferroxidases(MCF) in pancreatic iron homeostasis. We found that both HEPH and CP were expressed in the mouse pancreas, and that ablation of either MCF had limited effect on the pancreatic iron levels."
> "Q9Z0Z4-1","RefSeq","NP_851790.1","30182051","HEPH and CP are not essential for intestinal iron absorption but are required for proper systemic iron distribution. Publication Status: Online-Only"
> "Q9Z0Z4-1","RefSeq","NP_851790.1","29355933","Results show that both HEPH and CP are expressed in subcutaneous adipose tissue. Ablation of either MCF leads to a compensatory increase in the other, which contributes to the balance of iron status. However, ablation of both induces severe iron deposition in adipocytes and displays disordered carbohydrate metabolism characterized as type 2 diabetes."
8395a11154,11155
> "Q80W32-1","RefSeq","NP_848465.1","24849454","Iqcg is specifically required for spermiogenesis in mammals Publication Status: Online-Only"
> "Q80W32-1","RefSeq","NP_848465.1","24362311","Loss of Iqcg disrupts spermiogenesis such that tail formation either occurs incompletely or breaks apart from the sperm heads. Publication Status: Online-Only"
8413a11174
> "P82348-1","RefSeq","NP_036022.1","28821434","Cleavage of beta-DG still occurred when both MMP-2 and MMP-9 were knocked out in gamma - sarcoglycan-deficient mice. The study found that up-regulation of MMP-14 is capable of cleaving beta-DG, and it may be involved in the pathogenesis of sarcoglycanopathy."
8416a11178,11179
> "Q8QZY2-1","RefSeq","NP_777271.3","22029865","Data show significant evidence of linkages were obtained with NMR signals characterizing the glycerate (LOD10-42) at the mutant glycerate kinase locus, which demonstrate the power of metabolomics to identify the biological function of genetic variants."
> "Q8QZY2-1","RefSeq","NP_777271.3","19372376","Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~73%."
8425d11187
< "Q9CQG3-1","RefSeq","NP_080297.1","15950311","Data support the notion that MIZIP might interact with melanin-concentrating hormone receptor 1 (MCHR1) in a cell type specific manner in vivo, suggesting a role in the regulation of MCH signalling in distinct regions of the mammalian brain"
8428a11191,11193
> "O08989-1","RefSeq","NP_032650.1","29340604","This study demonstrated that M-Ras is recruited to the membrane of phagocytic cups and contributes to the regulation of phagosome formation in macrophages."
> "O08989-1","RefSeq","NP_032650.1","26516777","Expression of the muscarinic M2 and M3 receptors that mediate the cholinergic contractile stimuli of the detrusor muscle was dysregulated in both Mras-/- males and females, although only males exhibited a urinary phenotype. Publication Status: Online-Only"
> "O08989-1","RefSeq","NP_032650.1","23863483","Overexpression of MRAS in mouse embryonic stem cells leads to different cellular phenotypes."
8433a11199
> "Q8BMS4-1","RefSeq","NP_766275.1","21447381","Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues"
8436a11203,11209
> "O88888-1","RefSeq","NP_061228.1","28634075","Mint3 depletion attenuated metastasis to the lungs in breast cancer model mice."
> "O88888-1","RefSeq","NP_061228.1","28507122","APBA3-deficient mice show reduced metastasis, with no apparent effect on primary tumor growth. APBA3 deficiency in inflammatory monocytes hampers glycolysis-dependent chemotaxis of cells toward metastatic sites."
> "O88888-1","RefSeq","NP_061228.1","27698125","We have identified Mint3 as a physiological positive regulator of TLR3/4 and RIG-I-induced IFN-beta production and have outlined a feedback mechanism for the control of antiviral immune responses."
> "O88888-1","RefSeq","NP_061228.1","17687045","Binding of Munc18-1 to closed, target-SNARE syntaxin 1 stimulates vesicle docking and regulates the consecutive priming step during exocytosis of secretory or synaptic vesicles."
> "O88888-1","RefSeq","NP_061228.1","17167098","Mints are important regulators of presynaptic neurotransmitter release that are essential for mouse survival."
> "O88888-1","RefSeq","NP_061228.1","14990567","Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV"
> "Q8VC04-1","RefSeq","NP_659079.1","26215746","Data suggest that mouse Tmem106a might be a new trigger of macrophage activation and have some influence toward the M1 state through the activation of the MAPKs and NF-kappaB pathway Publication Status: Online-Only"
8440a11214
> "Q8BHC7-1","RefSeq","NP_084053.3","19358743","Findings suggest that mRHBDD1 may be associated with mammalian spermatogenesis. Publication Status: Online-Only"
8443a11218,11220
> "Q3UZ39-1","RefSeq","NP_032541.1","24690174","Experiments in nude mice demonstrated better response of LRRFIP1 overexpressing glioblastoma multiforme xenografts to teniposide."
> "Q3UZ39-1","RefSeq","NP_032541.1","20586614","Regulates a rapid type I interferon response"
> "Q3UZ39-1","RefSeq","NP_032541.1","20453844","LRRFIP1 and its downstream partner beta-catenin constitute another coactivator pathway for IRF3-mediated production of type I interferon"
8453a11231,11233
> "Q8CJG1-1","RefSeq","NP_700452.2","26995025","Up-regulated in murine macrophage RAW264.7 cells transfected by Echinococcus multilocularis miR-71"
> "Q8CJG1-1","RefSeq","NP_700452.2","24992693","Results from the liver show that, siRNA targets 3'UTR and the coding sequence (CDs) of endogenous genes in the presence Ago2 but in its absence, only 3'UTR-targeted siRNA-mediated knockdown are active with the help of Ago1 and Ago3. Publication Status: Online-Only"
> "Q8CJG1-1","RefSeq","NP_700452.2","10512872","Describes cloning rat sequence and used RNA interference to show that the GERp95 orthologue in C. elegans is important for maturation of germ-line stem cells in the gonad."
8459,8467c11239,11243
< "Q80TQ2-1","RefSeq","NP_001121643.1","30964341","IL-33 mediated immunoregulation in pulmonary adenocarcinoma by improving DC-induced T cell proliferation by upregulating CYLD expression"
< "Q80TQ2-1","RefSeq","NP_001121643.1","30554661","CYLD in the vasculature may be a novel therapeutic target, especially in the early preventive intervention against the initiation of age-related atherogenesis."
< "Q80TQ2-1","RefSeq","NP_001121643.1","29291351","Our findings demonstrate that CYLD mitigates Nonalcoholic steatohepatitis severity and identify the CYLD-TAK1 axis as a promising therapeutic target for management of the disease."
< "Q80TQ2-1","RefSeq","NP_001121643.1","29259980","The present results support the involvement of CYLD in the regulation of NF-kappaB inflammatory signaling induced by elevated glucose, implicating CYLD as a potential therapeutic target of diabetic nephropathy ."
< "Q80TQ2-1","RefSeq","NP_001121643.1","17392286","A critical role for CYLD in regulating the basal activity of NF-kappaB and maintaining the naive phenotype and proper activation of B cells."
< "Q80TQ2-1","RefSeq","NP_001121643.1","17053834","CYLD limits inflammation and tumorigenesis by regulating ubiquitination in vivo"
< "Q80TQ2-1","RefSeq","NP_001121643.1","16713561","These data indicate that, depending on the external signals, Cyld can negatively regulate different NF-kappaB pathways; inactivation of TRAF2 controls survival and inflammation, while inhibition of Bcl-3 controls proliferation and tumor growth."
< "Q80TQ2-1","RefSeq","NP_001121643.1","16501569","Identifed CYLD as a positive regulator of proximal T cell receptor signaling in thymocytes"
< "Q80TQ2-1","RefSeq","NP_001121643.1","15226292","CYLD is induced by NF-kappaB"
---
> "Q80X71-1","RefSeq","NP_082268.2","30496365","Data show that the frontotemporal dementia (FTD)-causing C-terminal truncation of CHMP2B results in dendritic endolysosomal trafficking defects. Strikingly, we found that this trafficking defect could be rescued by the knockdown of the FTD risk factor Tmem106b."
> "Q80X71-1","RefSeq","NP_082268.2","30013069","TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins. Publication Status: Online-Only"
> "Q80X71-1","RefSeq","NP_082268.2","29855382","This work suggests that the protective TMEM106B haplotype may exert its effect in expansion carriers by counteracting lysosomal dysfunction resulting from a loss of C9ORF72. Publication Status: Online-Only"
> "Q80X71-1","RefSeq","NP_082268.2","28728022","Grn and Tmem106b genes have opposite effects on lysosomal enzyme levels, and their interaction determines the extent of neurodegeneration"
> "Q80X71-1","RefSeq","NP_082268.2","24872421","Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a)."
8470a11247,11248
> "Q8BXB6-1","RefSeq","NP_780525.1","27629937","OATP2B1 downregulation in mouse brain can suppress tolerance via blocking morphine and M6G brain transport. These findings might help to improve the pharmacological effects of morphine Publication Status: Online-Only"
> "Q8BXB6-1","RefSeq","NP_780525.1","26526067","OATP2B1 contributes to the uptake of SN-38 by intestinal tissues, triggering gastrointestinal toxicity."
8488,8489d11265
< "Q80UG5-1","RefSeq","NP_001106958.1","27939986","Observations suggested that Sept9 contributed to alleviate liver fibrosis might partially through promoting activated HSCs apoptosis and this anti-fibrogenesis effect might be blocked by DNMT-3a mediated methylation of Sept9"
< "Q80UG5-1","RefSeq","NP_001106958.1","23644740","The altered T-cell homeostasis caused by the loss of Sept9 results in an increase of CD8(+) central memory T-cells."
8495a11272
> "Q9CR56-1","RefSeq","NP_082300.1","20639196","KappaB-Ras2 is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA."
8502a11280,11286
> "O54804-1","RefSeq","NP_038518.2","26125130","Hepatic phosphatidylcholine is regulated by the circadian clock through a Bmal1-Rev-erbalpha-Chkalpha axis"
> "O54804-1","RefSeq","NP_038518.2","20525991","Enforced expression of either CK(alpha) or CCTalpha increased the rate of synthesis and the amount of PtdCho, and these cells initiated neuronal differentiation."
> "O54804-1","RefSeq","NP_038518.2","20026284","Lack of muscle degeneration in forelimbs of Chkb(-/-) mice is due to abundant choline kinase alpha and the stable homeostasis of phosphatidylcholine."
> "O54804-1","RefSeq","NP_038518.2","18029352","Chka is an essential gene for early embryonic development, but adult mice do not require full expression of the gene for normal levels of phosphatidylcholine."
> "O54804-1","RefSeq","NP_038518.2","17728180","Data suggest that the choline kinase alpha promoter has a distal element (-875/-867) that binds c-jun and the binding of c-jun is enhanced by treatment with CCl4."
> "O54804-1","RefSeq","NP_038518.2","16490392","Full-length cDNAs or their truncated or alanine-mutated versions for mouse CK-alpha1 and CK-beta were expressed in COS-7 cells."
> "O54804-1","RefSeq","NP_038518.2","11964179","Experimental evidence for the presence of heteromeric ChoK/EtnK in any source. The activity of ChoK/EtnK in the cell is controlled not only by the level of each isoform but also by their combination to form the active oligomer complex."
8510a11295,11302
> "Q60760-1","RefSeq","NP_034475.2","29555819","Grb10 gene could be reactivated in adult mouse liver by acute endoplasmic reticulum stress."
> "Q60760-1","RefSeq","NP_034475.2","19833122","Grb10 can influence reproductive strategy through the allocation of maternal resources such that offspring number is offset against size."
> "Q60760-1","RefSeq","NP_034475.2","18650936","Data indicate that bivalent chromatin, in combination with neuronal factors, controls the paternal expression of Grb10 in brain."
> "Q60760-1","RefSeq","NP_034475.2","17101788","Grb10 gene is expressed from the paternal allele in brain, but from the maternal allele in most other tissues."
> "Q8BG40-1","RefSeq","NP_083081.2","28791777","Katnb1 is ubiquitously expressed during embryonic development, although a stronger expression is seen in the crown cells of the gastrulation organizer, the murine node. Furthermore, null and hypomorphic Katnb1 gene mutations show a novel correlation between Katnb1 dysregulation and the development of impaired left-right signaling, including cardiac malformations."
> "Q8BG40-1","RefSeq","NP_083081.2","29097679","This study structurally and functionally characterized the interaction between the two katanin subunits that is mediated by the p60-MIT domain and the p80 C-terminal domain (p80-CTD). p60-MIT and p80-CTD form a tight heterodimeric complex, whose high-resolution structure was determined by X-ray crystallography. Publication Status: Online-Only"
> "Q8BG40-1","RefSeq","NP_083081.2","19261606","Cul3-deficient cells or Ctb9/KLHDC5-deficient cells show an increase in p60/katanin levels, indicating that Cul3/Ctb9/KLHDC5 is required for efficient p60/katanin removal"
> "A2AKQ0-1","RefSeq","NP_808400.1","17952091","Deficient mice develop a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures."
8512a11305,11309
> "Q4U4S6-1","RefSeq","NP_001077388.1","25772365","XIRP2 is required for maintenance of stereocilia integrity."
> "Q4U4S6-1","RefSeq","NP_001077388.1","25653358","XIRP2 is required for long-term maintenance of hair cell stereocilia, and its dysfunction causes hearing loss."
> "Q4U4S6-1","RefSeq","NP_001077388.1","23261932","Data show that mXinbeta (CMYA3/XIRP2) but not mXinalpha ((CMYA1/XIRP1) was uniquely up-regulated during the redistribution of intercellular junction from the lateral membrane of cardiomyocytes to their termini."
> "Q4U4S6-1","RefSeq","NP_001077388.1","17046827","Myomaxin functions directly downstream of MEF2A at the peripheral Z-disc complex in striated muscle potentially playing a role in regulating cytoarchitectural integrity"
> "Q4U4S6-1","RefSeq","NP_001077388.1","16500513","Upregulation due to Ang II-induced myocardial damage and not to blood pressure elevation per se"
8514d11310
< "Q8C1B7-1","RefSeq","NP_001297598.1","21824005","SEPT11 is involved in vesicle trafficking and may play a role in synaptic connectivity. Interestingly, mice that harbor a homozygous Sept11 null mutation, die in utero."
8516,8521c11312,11313
< "B2RPY5-1","RefSeq","NP_001297358.1","29386106","Gpr161 restricts cerebellar granule cell progenitor production by preventing premature and sonic hedgehog-dependent pathway activity, highlighting the importance of basal pathway suppression in tumorigenesis"
< "B2RPY5-1","RefSeq","NP_001297358.1","29222391","Gpr161 promotes forelimb formation, regulates limb patterning, prevents periarticular chondrocyte proliferation and drives osteoblastogenesis in intramembranous bones in a cilium-dependent manner. Publication Status: Online-Only"
< "Q3UUV5-1","RefSeq","NP_001028358.1","27181093","This study shows that Skap1-deficient (skap1-/-) mice are highly resistant to the induction of collagen-induced arthritis"
< "Q3UUV5-1","RefSeq","NP_001028358.1","26905930","SKAP1 can affect the function of talin in T-cells needed for optimal T-cell/dendritic cell conjugation"
< "Q3UUV5-1","RefSeq","NP_001028358.1","25851535","In this study, the authors identified that the ADAP-SKAP55 signaling module reduced CD8(+) cytotoxic T lymphocyte cytotoxicity and enhanced PD-1 expression in a Fyn-, Ca(2+)-, and NFATc1-dependent manner."
< "Q3UUV5-1","RefSeq","NP_001028358.1","17646386","Results identify a clear effector role for SKAP-55 in LFA-1 adhesion in peripheral T cells and demonstrate that dependency on SKAP-55 and ADAP differs among T cells and differs with the strength of the TCR signal."
---
> "Q9CQL1-1","RefSeq","NP_079840.2","23917022","Findings show 2 genes MAGOH and MAGOHB are expressed in mammals; in macrophages, expression of MAGOHB but not MAGOH mRNA increases after LPS stimulation; both MAGOH proteins interact with other exon junction complex (EJC) components, incorporate into mRNA-bound EJCs and activate nonsense-mediated decay"
> "Q9CQL1-1","RefSeq","NP_079840.2","23358417","Reexpression of KMT2B was sufficient to reinstate an active MagohB promoter."
8522a11315,11319
> "P58307-1","RefSeq","NP_945197.2","30251681","OX1R expression is associated with a strong specific immunomodulatory effect of orexin-A via OX1R and down-regulation of the pro-inflammatory cytokine production and secretion, as shown in two murine models recapitulating either the acute or chronic phase of ulcerative colitis."
> "P58307-1","RefSeq","NP_945197.2","30341359","Under enforced wakefulness (EW), or after cage change (CC), Hcrtr1 knockout mice exhibited a weakened ability to lower infra-theta; frequencies (1-7 Hz), and mount a robust, narrow-bandwidth, high-frequency theta; rhythm (~8.5 Hz). A fast-gamma (55-80 Hz) response, whose dynamics closely parallelled theta;, also diminished, while beta/slow-gamma activity (15-45 Hz) increased. Publication Status: Online-Only"
> "P58307-1","RefSeq","NP_945197.2","28690152","Results thus suggest that type 1 diabetes mellitus impairs testicular steroidogenesis and glucose homeostasis through inhibition of orexin A/OX1R signaling cascade due to decreased OX1R expression in adult mice, thereby affecting germ cell survival and their proliferation in the testis."
> "Q8CHH9-1","RefSeq","NP_149156.1","27084579","SEPT8 modulates beta-amyloidogenic processing of APP through a mechanism affecting the intracellular sorting and accumulation of BACE1."
> "Q8CHH9-1","RefSeq","NP_149156.1","21770032","Signaling protein ras-related protein rab-7A and septin 8 levels were significantly higher in hippocampus of poor contextual fear conditioning extinguishers."
8529c11326,11327
< "Q9D9R7-1","RefSeq","NP_001033705.2","16488114","Dmrt8.1 mRNA was detected in Sertoli cells by in situ hybridization."
---
> "Q80ZN5-1","RefSeq","NP_081300.1","15645076","Cymg1 might play an important role in mouse spermatogenesis and sexual maturation"
> "Q80ZN5-1","RefSeq","NP_081300.1","15689628","Cymg1 expression level varied in the different developmental stages of mouse testis, and were coincidental with spermatogenesis and sex maturation."
8533a11332
> "Q3V0J1-1","RefSeq","NP_001032901.1","20375344","Als2cr4 may be involved in membrane transport between the photoreceptor inner and outer segments and may be a key component in maintaining the structural integrity of the outer segment"
8537a11337,11341
> "Q9WUT7-1","RefSeq","NP_034043.1","29154408","These results showed a site- and cell-specific expressions of Ccl25 and its receptor Ccr9 within both maternal and embryonic compartments of implantation sites and suggested a role in inducing specific Ccr9+ leukocytes at the maternal-fetal interface during the initial steps of embryo implantation in the mouse model"
> "Q9WUT7-1","RefSeq","NP_034043.1","27585634","Abrogation of CCR9 improved the post-myocardial infarction survival rate and left ventricular (LV) dysfunction and decreased the infarct size. The data reveal that CCR9 serves as a novel modulator of pathological progression following myocardial infarction through NF-kappaB and MAPK signaling. Publication Status: Online-Only"
> "Q9WUT7-1","RefSeq","NP_034043.1","27795621","CCR9 and CCL25 expressions are induced in the early stages of airway inflammation and they have an important role modulating eosinophils and lymphocytes recruitment at the first stages of inflammatory process"
> "Q9WUT7-1","RefSeq","NP_034043.1","11751956","Characterization of CCR9 expression during T cell development"
> "Q9WUT7-1","RefSeq","NP_034043.1","10229797","This gene is a mouse CCR9. See also GenBank files AJ132336 and AJ131357."
8542,8543c11346
< "Q99LJ7-1","RefSeq","NP_001164165.1","25762510","Findings suggest that RC/BTB2 is a necessary component of the process of formation of primary cilia in somatic cells, perhaps through the transportation of cargos from Golgi bodies to centrosomes for cilia assembling."
< "Q99LJ7-1","RefSeq","NP_001164165.1","22768142","The expression and localization of mouse RC/BTB2 in the testis and male germ cells, was characterized."
---
> "Q61418-1","RefSeq","NP_035464.3","21282478","In Mus spretus, the chloride channel 4 gene Clcn4-2 is X-linked and dosage compensated by X up-regulation and X inactivation, while in the closely related mouse species Mus musculus, Clcn4-2 has been translocated to chromosome 7."
8562a11366,11374
> "Q9WV71-1","RefSeq","NP_075535.1","24387305","Expression of imprinted gene Asb4 was unregulated in haploid androgenetic/gynogenetic blastocysts."
> "Q9WV71-1","RefSeq","NP_075535.1","24586788","In functional endothelial co-culture assays, JAR cells ectopically expressing ASB4 increased endothelial cell turnover and stabilized endothelial tube formation, both of which are hallmarks of vascular differentiation within the placenta. Publication Status: Online-Only"
> "Q9WV71-1","RefSeq","NP_075535.1","11820791","Asb4 has been identified as an imprinted gene by high-throughput screening using RIKEN cDNA microarray."
> "Q8BTI9-1","RefSeq","NP_083370.2","29902570","The crucial role of p110beta and the more subtle role of p110alpha in the production of PIP3 molecular species following platelet stimulation has been demonstrated."
> "Q8BTI9-1","RefSeq","NP_083370.2","27700986","Collectively, these findings provide a mechanistic account of how Rac1-dependent membrane raft localization regulates differential activation of distinct phosphoinositide 3-kinase isoforms and offer insight into why PTEN-deficient cancers depend on p110beta. Publication Status: Online-Only"
> "Q8BTI9-1","RefSeq","NP_083370.2","27531651","P110beta transduces GPCR signals in the context of coincident activation by an RTK. The p110beta-Gbetagamma interaction was also required for neutrophils to generate reactive oxygen species in response to the Fcgamma receptor-dependent recognition of immune complexes Publication Status: Online-Only"
> "Q8BTI9-1","RefSeq","NP_083370.2","12869549","P110beta is the major class I catalytic isoform required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by primary macrophages"
> "Q8BTI9-1","RefSeq","NP_083370.2","12870650","P85 and p110 subunits of PI3-kinase play a role in NF-kappaB activation through interaction with tyrosine-phosphorylated I(kappa)B-alpha and contribute to tyrosine phosphorylation of p65 NF-kappaB"
> "Q8BTI9-1","RefSeq","NP_083370.2","11919689","Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase"
8565a11378,11379
> "Q9DAA4-1","RefSeq","NP_080593.1","25921412","Interstrain hybridization obtained Prss37(-/-)EGFP(tg/+) males produced sperm with impaired oviduct-migrating ability as visualized under fluorescence microscope, compared with Prss37(+/+)EGFP(tg/+) counterparts"
> "Q9DAA4-1","RefSeq","NP_080593.1","23553430","Prss37 deficiency causes the absence of mature Adam3 in sperm and a defect in sperm migration from uterus into oviduct, which mainly accounts for male infertility of Prss37-null mice Publication Status: Online-Only"
8578c11392,11402
< "Q80UW0-1","RefSeq","NP_001277396.1","15499561","6OST2 is more mesenchymal than its isoenzymes during development"
---
> "P63242-1","RefSeq","NP_853613.1","26037925","Our results provide the first genetic evidence that the hypusine modification in eIF-5A is crucial for homeostasis in mammals"
> "P63242-1","RefSeq","NP_853613.1","21850436","Knockout of either the eIF5A-1 gene (Eif5a) or of the deoxyhypusine synthase gene (Dhps) caused early embryonic lethality in mice, indicating the essential nature of both eIF5A-1 and deoxyhypusine synthase in mammalian development"
> "P63242-1","RefSeq","NP_853613.1","15377278","A decrease in either active eIF5A or polyamines inhibits cell growth, indicating that eIF5A and polyamines are independently involved in cell growth"
> "P63242-1","RefSeq","NP_853613.1","11161802","Eukaryotic initiation factor 5A (eIF5A) (eIF-4D, eIF-5A) stimulates ribosomal peptidyltransferase activity, transport of HIV-1-mRNAs and binds exportins 1 and 4. Contains hypusine at lys 50. Mouse EIF5A1 and EIF5A2 encode two isoforms: eIF5AI and eIF5AII."
> "Q9D180-1","RefSeq","NP_081065.2","17971504","1110020C03Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
> "O70491-1","RefSeq","NP_033317.2","28733465","The STRA6 is potent regulators of diurnal insulin responses and suggest that the holo-RBP/STRA6 signaling axis may represent a novel therapeutic target in type II diabetes."
> "O70491-1","RefSeq","NP_033317.2","27256691","Suppression of STRA6 cascades is involved in renal apoptosis and fibrosis caused by electronegative low density lipoproteins."
> "O70491-1","RefSeq","NP_033317.2","27189978","These results showed that STRA6 is critical for vitamin A homeostasis and the adaption of this process to the fluctuating supply of the vitamin.-"
> "O70491-1","RefSeq","NP_033317.2","24852372","Studies indicate that STRA6 is indeed a bona fide vitamin A transporter and provide novel insights into the regulatory mechanism that governs vitamin A homeostasis in peripheral tissues."
> "P48543-1","RefSeq","NP_032455.2","27012303","GIRK-3 knock-out mice show significant ethanol conditioned place preference and reward compared to wild-type littermates. Erratum:[Alcohol Clin Exp Res. 2016 Oct;40(10 ):2253. PMID: 27696524]"
> "P48543-1","RefSeq","NP_032455.2","25964320","GIRK3 appears to be a critical gatekeeper of ethanol incentive salience and a potential target for the treatment of excessive ethanol consumption."
8587a11412,11413
> "Q61179-1","RefSeq","NP_032420.1","31266943","Both type I IFN and IFN-gamma cause promoter binding of a complete ISGF3 complex containing STAT1, STAT2 and IRF9. Publication Status: Online-Only"
> "Q61179-1","RefSeq","NP_032420.1","29317535","Surface features in the interacting domains of IRF9 and STAT2 have diverged to enable specific interaction between these family members and to enable the antiviral response."
8588a11415,11422
> "P30993-1","RefSeq","NP_031603.2","30634407","These data indicate that MERS-CoV infection induces overactivation of complement, which may contribute to pyroptosis and inflammation. Pyroptosis and inflammation were suppressed by inhibiting C5aR1. Publication Status: Online-Only"
> "P30993-1","RefSeq","NP_031603.2","30294325","C3aR and C5aR1 are potent regulators of ethanol-induced adipose inflammation in murine model of alcohol-related liver disease (ALD). C5aR1 modulates the impact of chronic ethanol on the content of the adipose secretome, likely contributing to intra-organ injury in ALD. Publication Status: Online-Only"
> "Q61831-1","RefSeq","NP_001297615.1","28664455","JNK1 and/or JNK3 are promising targets for the prevention of cell death and inflammation during epileptogenesis."
> "Q61831-1","RefSeq","NP_001297615.1","29238071","Together these data indicate that ONA induces APP expression and that gamma-secretase cleavage of APP releases AICD, which upregulates JNK3 leading to RGC death. This pathway may be a novel target for neuronal protection in optic neuropathies and other forms of neurotrauma."
> "P57787-1","RefSeq","NP_109621.1","21484790","MCT4 expression markedly increased the gradient between intracellular and extracellular pH from 0.14 to 0.43."
> "P57787-1","RefSeq","NP_109621.1","20022372","In situ hybridization survey of MCT subtypes in placenta detected intense mRNA expression of MCT1, MCT4, & MCT9 (gestational day 11.5 through day 18.5); subcellular localization of MCT1 & MCT4 in cell membrane is opposite polarity found in human."
> "P57787-1","RefSeq","NP_109621.1","18385447","Unique roles for slc16a3 in monocarboxylate transport and pH regulation during preimplantation development."
> "Q9R0A5-1","RefSeq","NP_001156419.1","19509051","Data show that Nek3 influences neuronal morphogenesis and polarity through effects on microtubules."
8599a11434,11436
> "B9EJ86-1","RefSeq","NP_780698.2","25347070","Orp8 deficiency in bone marrow-derived cells reduces atherosclerotic lesion progression in LDL receptor knockout mice. Publication Status: Online-Only"
> "B9EJ86-1","RefSeq","NP_780698.2","23554939","Osbpl8 deficiency in mouse causes an elevation of high-density lipoproteins and gender-specific alterations of lipid metabolism."
> "B9EJ86-1","RefSeq","NP_780698.2","22683860","Aspects of ORP8 function in macrophages not directly involving lipid metabolism, but rather associated with nuclear functions, microtubule organization, and migration capacity"
8614a11452,11453
> "Q6PAL0-1","RefSeq","NP_950193.1","25457167","BEND3 is a key factor in mediating a switch from constitutive to facultative heterochromatin. Erratum:[Mol Cell. 2015 Jan 8;57(1):202. Simboeck, Elisabeth [Added]]"
> "P16646-1","RefSeq","NP_032911.1","28108290","Selective suppression of the Pmp22 mutant allele by non-viral delivery of siRNA alleviates the demyelinating neuropathic phenotypes of Charcot-Marie-Tooth disease in vivo"
8615a11455,11456
> "O70546-1","RefSeq","NP_033509.1","30389724","Overexpression of the H3K27me3-specific demethylase KDM6A, but not of KDM6B, improves the efficiency of somatic cell nuclear transfer."
> "O70546-1","RefSeq","NP_033509.1","30006524","Lymphomas with low UTX expression express high levels of Efnb1, and cause significantly poor survival. Publication Status: Online-Only"
8633a11475,11478
> "O08715-1","RefSeq","NP_033778.2","30093535","Genetic disinhibition of Drp1 via knock-out of the mitochondrial protein kinase A (PKA) scaffold AKAP1 exacerbates stroke injury in mice. Mechanistically, we show that electron transport deficiency, increased superoxide production, and Ca(2+) overload result from genetic disinhibition of Drp1."
> "O08715-1","RefSeq","NP_033778.2","29388469","Loss of AKAP1 expression is associated with acute lung injury."
> "O08715-1","RefSeq","NP_033778.2","28569781","AKAP1 is a transcriptional target of Myc, and it supports mTOR pathway and the growth of cancer cells. Publication Status: Online-Only"
> "O08715-1","RefSeq","NP_033778.2","28500286","These results identify a novel AKAP-mediated biochemical mechanism that increases TRPA1 sensitivity in peripheral sensory neurons, and likely contributes to persistent mechanical hypersensitivity. Publication Status: Online-Only"
8642a11488
> "A2AFR3-1","RefSeq","NP_001277357.1","29267967","The findings point to an important role of FRMPD4 in normal cognitive development and function in humans and mice, and support the hypothesis that FRMPD4 mutations cause ID by disrupting dendritic spine morphogenesis in glutamatergic neurons."
8644a11491,11492
> "Q9D9T6-1","RefSeq","NP_082923.1","27053129","Spermatogenesis-associated protein 3 (Spata3) and dickkopf-related protein 2 (Dkk2) were confirmed to interact with MIC3. The tandem repeat EGF domains of MIC3 were critical in mediating the interactions with the identified host proteins. The results show that MIC3 interacts with host proteins that are involved in reproduction, growth, and development."
> "Q9D9T6-1","RefSeq","NP_082923.1","18551385","Mtsarg1 and Mtsarg1-beta may play an important role in mouse testicular function and in spermatocyte development."
8653a11502,11505
> "Q9WV30-1","RefSeq","NP_598718.2","30413537","These results indicate that (i) RNF183 is predominantly expressed in the normal renal medulla, (ii) NFAT5 stimulates transcriptional activation of Rnf183 by binding to its cognate binding motif in the Rnf183 promoter, and (iii) RNF183 protects renal medullary cells from hypertonicity-induced apoptosis."
> "Q9WV30-1","RefSeq","NP_598718.2","30327417","Results uncover an NFAT5-regulated mechanism that maintains CIITA and MHCII expression in macrophages and thus modulates their T lymphocyte priming capacity."
> "Q9WV30-1","RefSeq","NP_598718.2","30293684","Data indicate a role of nuclear factor of activated T-cell 5 (NFAT5) in the development of melanoma and as a marker of cell migration, metastasis, and a therapeutic target in melanoma."
> "Q9WV30-1","RefSeq","NP_598718.2","11780147","Structure of the NFAT5/TonEBP DNA binding domain bound to a TonE DNA element. The structure shows DNA encirclement by two dimerization interfaces: (1) at the TIG domain similar to NF-kappaB family members, and (2) at the DNA recognition domain."
8659a11512,11517
> "Q9D709-1","RefSeq","NP_077208.1","30463955","Tmem79 has a role in oxidative stress protection."
> "Q9D709-1","RefSeq","NP_077208.1","24060273","Tmem79(ma/ma) mutation is responsible for the spontaneous dermatitis phenotype in matted mice, probably as a result of impaired lamellar granule secretory system and altered stratum corneum barrier function."
> "O70263-1","RefSeq","NP_034857.3","30185604","Retrograde regulation of mossy fiber axon targeting and terminal maturation via postsynaptic Lnx1."
> "O70263-1","RefSeq","NP_034857.3","29121065","These findings provide functional insights into the LNX protein family, particularly the neuronal LNX1p70 isoform. Publication Status: Online-Only"
> "O70263-1","RefSeq","NP_034857.3","19295125","LNX1p80 is involved in the ubiquitylation, endocytosis and lysosomal degradation of claudins, and the turnover of tight junctions is regulated by ubiquitylation."
> "O70263-1","RefSeq","NP_034857.3","12468544","The PDZ domain-containing protein ligand-of-numb protein-X (LNX) is found in complex with the coxsackievirus and adenovirus receptor (CAR)"
8665,8666c11523,11524
< "Q8R3V5-4","RefSeq","NP_001276638.1","28455444","Data (including data from studies in knockout mice) suggest that Sh3glb2 regulates trafficking of endocytic vesicles and autophagosomes to late endosomes or lysosomes; despite having an intracellular localization and tissue distribution similar to endophilin B1, endophilin B2 is dispensable for mitochondrial apoptosis."
< "Q8R3V5-4","RefSeq","NP_001276638.1","18303116","The immunodominant SPAS-1 epitope SNC9-H(8) arose from a point mutation in one allele of the gene in transgenic adenocarcinoma of mouse prostate tumor cells"
---
> "Q8BJ64-1","RefSeq","NP_780552.1","28663368","Data, including data from studies using transgenic/knockout mice, suggest that betaine accumulates during oocyte meiotic maturation; the mechanism appears to be transient activation of Chdh; Chdh is again inactive in the zygote (that is, after fertilization)."
> "Q8BJ64-1","RefSeq","NP_780552.1","20371614","Loss of CHDH activity resulted in decreased testicular betaine and increased choline and PCho concentrations; impaired fertility was due to diminished sperm motility in the Chdh(-/-) males Erratum:[FASEB J. 2018 May;32(5):2899. PMID: 29698116]"
8668c11526
< "P48540-1","RefSeq","NP_001288286.1","30651543","Study utilizing mouse kidney cultures and time-lapse imaging provided quantitative experimental support that a ligand-receptor-based Turing mechanism, implemented via GDNF-RET signaling, specifies the areas of outgrowth during kidney branching morphogenesis. The positive feedback between GDNF and WNT11 enables the dense packing of the ureteric buds. Publication Status: Online-Only"
---
> "Q8VE42-1","RefSeq","NP_062657.2","26043108","ANKRD49 plays an important role in spermatogenesis via promotion of autophagy-dependent survival. Publication Status: Online-Only"
8676,8678c11534,11543
< "Q9D486-1","RefSeq","NP_001156734.1","27650733","Unlike the human CMIP gene, only one Wt1 response element was identified in the mouse Cmip proximal promoter located at position -217/-206."
< "Q9D486-1","RefSeq","NP_001156734.1","23200848","The c-mip protein is involve in regulating nephrin phosphorylation through Csk-Cbp/PAG-Fyn signaling pathway."
< "Q9D486-1","RefSeq","NP_001156734.1","20808911","Expression of Cmip in the mouse hippocampus is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase). Publication Status: Online-Only"
---
> "P27792-1","RefSeq","NP_032561.2","30185409","Lyl1 can maintain primitive erythropoiesis. Publication Status: Online-Only"
> "P27792-1","RefSeq","NP_032561.2","24532287","Loss of Lyl1 is associated with lung endothelial barrier disruption."
> "P27792-1","RefSeq","NP_032561.2","23926305","Lyl1 is critical for all oncogenic functions of Lmo2, including upregulation of a stem cell-like gene signature, aberrant self-renewal of thymocytes, and subsequent generation of T-cell leukemia."
> "Q80UG5-1","RefSeq","NP_059076.1","27939986","Observations suggested that Sept9 contributed to alleviate liver fibrosis might partially through promoting activated HSCs apoptosis and this anti-fibrogenesis effect might be blocked by DNMT-3a mediated methylation of Sept9"
> "Q80UG5-1","RefSeq","NP_059076.1","23644740","The altered T-cell homeostasis caused by the loss of Sept9 results in an increase of CD8(+) central memory T-cells."
> "Q91Y82-1","RefSeq","NP_035307.2","29604205","The data are exciting because they demonstrate that Klk6 can influence astrocyte plasticity through receptor-dependent mechanisms."
> "Q91Y82-1","RefSeq","NP_035307.2","29086442","Kallikrein 6 secreted by oligodendrocytes plays a critical role in the pathogenesis of experimental autoimmune encephalomyelitis."
> "Q91Y82-1","RefSeq","NP_035307.2","27621228","Expression strongly induced in psoriasiform epidermis; crucial for development of imiquimod-induced psoriasiform dermatitis"
> "Q91Y82-1","RefSeq","NP_035307.2","27533119","Klk6 represents an important target for conditions in which pro-inflammatory responses play a critical role in disease development, including MS"
> "Q91Y82-1","RefSeq","NP_035307.2","27283773","Data show that kallikrein 6 (KLK6) expression is induced in mouse and human skin during chronic glucocorticoid treatment."
8680a11546,11549
> "Q7TPD1-1","RefSeq","NP_001335177.1","30898767","A bulla cavitation defect initiates the pathogenesis of otitis media in the established mouse model Jeff (Fbxo11(Jf/+) ). Publication Status: Online-Only"
> "Q7TPD1-1","RefSeq","NP_001335177.1","30526604","Through a loss-of-function screen authors found that a member of the E3 ubiquitin ligase complexes, FBXO11, specifically fuels tumor formation of a non-EMT-like clone by restraining the p53/p21 pathway. Interestingly, in the related EMT-like clone, FBXO11 operates through the BCL2 pathway with little or no impact on tumorigenesis. Publication Status: Online-Only"
> "Q7TPD1-1","RefSeq","NP_001335177.1","27166359","FBXO11 inactivation was associated with the development of lymphoproliferative disorders in mice."
> "Q7TPD1-1","RefSeq","NP_001335177.1","26471094","FBXO11 regulates the TGF-beta pathway in the embryonic lung via cross-talk with p53."
8681a11551,11552
> "Q9CSU0-1","RefSeq","NP_081710.1","28893536","Mechanistically, CREPT regulated beta-catenin/TCF4/cyclin D1 pathway in BC. In conclusion, the data suggested that miR-138/CREPT involved BC progression, providing potential therapeutic targets for BC."
> "Q9CSU0-1","RefSeq","NP_081710.1","24982424","Study suggests that CREPT acts as an activator to promote transcriptional activity of the beta-catenin.TCF4 complex in response to Wnt signaling."
8685a11557,11559
> "B1AYB6-1","RefSeq","NP_001277585.1","25001218","This study indicates that the Mbd5(+/) (GT) mouse model recapitulates most of the hallmark phenotypes observed in 2q23.1 deletion carriers including abnormal social behavior, cognitive impairment, and motor and craniofacial abnormalities."
> "B1AYB6-1","RefSeq","NP_001277585.1","24750026","MBD5 regulates iron metabolism via methylation-independent genomic targeting of Fth1."
> "B1AYB6-1","RefSeq","NP_001277585.1","23077600","These results indicate Mbd5 as an essential factor for mouse postnatal growth and maintenance of glucose homeostasis"
8700a11575,11584
> "Q6PCN7-1","RefSeq","NP_033236.2","29975766","Findings 1) prove the truncated Hltf protein isoform is a transcription factor, 2) establish a functional link between AS of Hltf and immunosuppression at the feto-maternal interface, 3) correlate intron retention with the absence of DNA methylation, and 4) underscore the importance of differential splicing analysis to identify Hltf's functional diversity. Publication Status: Online-Only"
> "Q6PCN7-1","RefSeq","NP_033236.2","24278285","Silencing Hltf during heart organogenesis compromised DNA double-strand break repair, and caused aberrant collagen biogenesis altering the structural network that transmits cardiomyocyte force into muscle contraction Publication Status: Online-Only"
> "Q6PCN7-1","RefSeq","NP_033236.2","23826137","Data show a role of helicase-like transcription factor (hltf) in the G2/m transition and apoptosis in brain Publication Status: Online-Only"
> "Q9JJ78-1","RefSeq","NP_075698.1","27355132","This study shows that remote ischemic postconditioning protects against renal ischemia/reperfusion injury via activation of TOPK/PTEN/Akt signaling pathway"
> "Q9WUU8-1","RefSeq","NP_001258384.1","29930103","These data show that the disease susceptibility proteins A20 and ABIN-1 synergistically prevent intestinal inflammation by restricting IEC death and preserving tissue integrity."
> "Q9WUU8-1","RefSeq","NP_001258384.1","29709475","Reduced expression of TNIP1 was determined in hepatic ischemia/reperfusion (I/R) injury compared to normal mice. Then, TNIP1 transgene mice were used to determine the effects of TNIP1 on mice after treatment for I/R."
> "Q9WUU8-1","RefSeq","NP_001258384.1","29203883","It has been proposed that ABIN-1 provides a critical link between methionine1 ubiquitylation mediated by the LUBAC complex and lysine63 deubiquitylation by phospho-A20 to modulate the activation of RIPK1."
> "Q9WUU8-1","RefSeq","NP_001258384.1","28935578","These studies define a novel role for ABIN1 dysfunction and NF-kappaB in mediating glomerulonephritis through proinflammatory activation of podocytes."
> "Q9WUU8-1","RefSeq","NP_001258384.1","27807192","Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1"
> "Q9WUU8-1","RefSeq","NP_001258384.1","15722346","Using a murine model of allergen-induced asthma, we have demonstrated that adenovirus-mediated delivery of ABIN-1 to the lung epithelium results in a reduction of allergen-induced eosinophil infiltration into the lungs."
8714a11599,11600
> "Q8BXR9-1","RefSeq","NP_663500.2","26941018","Oxysterol-binding protein-like 6 is a novel regulator of cholesterol trafficking that is part of the miR-33 and miR-27b target gene networks contributing to the maintenance of cholesterol homeostasis."
> "Q9QUI0-1","RefSeq","NP_058082.2","30266829","Nfix is regulated through the RhoA/ROCK axis, which maintains embryonic myogenesis. Publication Status: Online-Only"
8716a11603,11609
> "Q8K558-1","RefSeq","NP_082039.1","30282800","Findings suggest that TLT-1 uses fibrinogen to govern the transition between inflammation and hemostasis and facilitate controlled leukocyte transmigration during the progression of ARDS."
> "Q8K558-1","RefSeq","NP_082039.1","30120105","TREM-like transcript 1: a more sensitive marker of platelet activation than P-selectin in humans and mice."
> "Q8K558-1","RefSeq","NP_082039.1","22761415","TLT-1s, alternative transcripts of triggering receptor expressed on myeloid cell-like transcript-1 (TLT-1), Inhibits the triggering receptor expressed on myeloid cell-2 (TREM-2)-mediated signaling pathway during osteoclastogenesis."
> "Q8K558-1","RefSeq","NP_082039.1","19436112","TLT-1 plays a protective role during inflammation by dampening the inflammatory response and facilitating platelet aggregation at sites of vascular injury"
> "Q8K558-1","RefSeq","NP_082039.1","16505478","A soluble fragment of the TLT-1 extracellular domain is found in serum of humans and mice and that an isoform of similar mass is released from platelets following activation with thrombin."
> "Q8K558-1","RefSeq","NP_082039.1","15100151","Expressed exclusively in platelets and megakaryocytes; expression is up-regulated upon platelet activation; is prepackaged into both MK and platelet alpha-granules; may regulate granule construction or dispersal"
> "Q8K558-1","RefSeq","NP_082039.1","12393607","Initial characterization of TREM-like transcript (TLT)-1; results indicate it is likely that TLT-1 regulates the signaling of the TREM family receptors"
8718a11612,11615
> "Q5FWI2-1","RefSeq","NP_001298006.1","29977037","Enhanced senescence levels in cholangiocytes from Mdr2(-/-) mice were reversed to normal in SR(-/-)/Mdr2(-/-) mice."
> "Q5FWI2-1","RefSeq","NP_001298006.1","28082350","Knockout of SCTR results in defective aldosterone biosynthesis/release and altered sensitivity of ENaCs to amiloride."
> "Q5FWI2-1","RefSeq","NP_001298006.1","20739612","Findings identify SCT and SCTR as novel elements of the ANGII osmoregulatory pathway in maintaining fluid balance in the body."
> "Q5FWI2-1","RefSeq","NP_001298006.1","20578263","Stable knockdown of SR expression reduced basal cholangiocyte proliferation. SR is an important trophic regulator sustaining biliary growth."
8722a11620,11625
> "Q6R2P8-1","RefSeq","NP_963904.2","26245904","NEIL2 plays an important role in long term genomic maintenance"
> "Q6R2P8-1","RefSeq","NP_963904.2","20175991","The beta2/beta3 loop where Lys50 is located in NEIL2 is important for DNA binding, presumably lies next to a phosphate-binding site, and may represent a target for regulation of the enzyme activity."
> "Q6R2P8-1","RefSeq","NP_963904.2","16920106","Results suggest a role for NEIL1 and 2 as backup deoxyribo-5'-phosphate lyases in mammalian cells."
> "Q6R2P8-1","RefSeq","NP_963904.2","16581765","Keap1 recruits NEH2 through binding to ETGE and DLG motifs."
> "Q6R2P8-1","RefSeq","NP_963904.2","15725623","Recombinant human DNA Polymerase beta and recombinant mpise NEIL2 associated with microtubules in situ and in vivo."
> "Q6R2P8-1","RefSeq","NP_963904.2","15533836","NEIL1 and NEIL2 are essential in the recognition of oxidized lesions arising from 8-oxoG and may play important roles in the repair of DNA damage induced by carcinogenic metals."
8723a11627,11633
> "Q09200-1","RefSeq","NP_082015.2","30521973","Study analyzed enzyme activity and intracellular localization of the products of mutant cDNAs from eleven cases of hereditary spastic paraplegia with mutation in the coding region of B4GALNT1, and noted a lack of enzyme activity in a majority of them except two family cases. Then compared profiles of clinical findings of patients with hereditary spastic paraplegia and abnormal phenotypes of B4galnt-KO mice."
> "Q09200-1","RefSeq","NP_082015.2","27102283","We used GM2/GD2 synthase (B4galnt1)-deficient mice to immunize by liposomes embedded with GD1alpha or acidic glycolipid fractions from brain of St3gal5-deficient mice. Specificities of established mAbs as analyzed by enzyme-linked immunosorbent assay and thin-layer chromatography-immunostaining were very high among various gangliosides."
> "P70170-1","RefSeq","NP_066379.2","28121062","Cardiac SUR2A levels were significantly increased while Kir6.2 levels were not affected. Hypoxia did not induce phosphorylation of extracellular signal-regulated kinases (ERK1/2) or protein kinase B (Akt), but triggered phosphorylation of AMP activated protein kinase (AMPK). AICAR, an activator of AMPK, increased the level of SUR2A in H9c2 cells. We conclude that oxygen increases SUR2A level by activating AMPK."
> "P70170-1","RefSeq","NP_066379.2","27086859","K(ATP) channels seem to play an essential role in murine myometrial motility via activation of SUR2B and Kir6.2"
> "P12849-1","RefSeq","NP_032949.3","30541888","EZH2 ensures normal cortical differentiation by repression of phosphodiesterases PDE1B, 3A, and 7A and of PRKAR1B."
> "Q07409-1","RefSeq","NP_032805.2","27539848","Protein-tyrosine phosphatase receptor type G (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system"
> "A0PK84-1","RefSeq","NP_001074412.1","29287726","Taken together, our results suggest that palmitoylation by ZDHHC22 at C241 in the CCN3 TSP1 domain may be required for the secretion of CCN3. Aberrant palmitoylation induces intracellular accumulation of CCN3, inhibiting neuronal axon growth."
8725a11636,11638
> "A2RT62-1","RefSeq","NP_001157697.1","24390425","FBXL16 negatively regulates the activity of B55alpha-PP2A to modulate the genesis of FLK1+ progenitor cells."
> "A2RT62-1","RefSeq","NP_001157697.1","17603280","SCIRR1 ise involved in the succeeding injury and/or repair processes of the injured spinal cord."
> "Q9D9J2-1","RefSeq","NP_082798.1","17971504","1700061J05Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
8740a11654
> "Q80X66-1","RefSeq","NP_598461.1","18160256","BTBD10 appears to behave as a suppressor of cell death including neuronal cell death related to amyotrophic lateral sclerosis and an enhancer of cell growth via its positive regulation of Akt phosphorylation."
8741a11656,11674
> "Q9JLM4-1","RefSeq","NP_062805.1","28661483","Zmym3 KO also resulted in up-regulated expression of meiotic genes in spermatogonia. These results show that ZMYM3 has an essential role in metaphase to anaphase transition during mouse spermatogenesis by regulating the expression of diverse families of genes. Publication Status: Online-Only"
> "Q9CWR0-1","RefSeq","NP_082303.2","26392029","In cultured neonatal cardiac fibroblasts, p63RhoGEF regulated the angiotensin II (Ang II)-dependent RhoA activation, the activation of the serum response factor, and the expression and secretion of CTGF."
> "Q9CWR0-1","RefSeq","NP_082303.2","23696743","Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Galpha(q/11)--p63RhoGEF--RhoA axis."
> "Q9CWR0-1","RefSeq","NP_082303.2","22449701","The Geft knockout mice develop normally and exhibit no discernable phenotype, suggesting Geft is dispensable for the development of the second heart field in mouse."
> "Q9CWR0-1","RefSeq","NP_082303.2","21885830","Signaling through p63RhoGEF provides a novel mechanism for selective regulation of blood pressure."
> "Q9CWR0-1","RefSeq","NP_082303.2","18541910","Bves directly interacts with GEFT and is a novel regulator of the Rac1 and Cdc42 signaling cascades."
> "Q9CWR0-1","RefSeq","NP_082303.2","12547822","This protein induces cell proliferation, transformation, and migration."
> "Q6NWV3-1","RefSeq","NP_112454.2","30476139","The C11ORF74, interacts with the IFT-A complex via the IFT122 subunit and is accumulated at the distal tip in the absence of an IFT-A subunit IFT139, suggesting that at least a fraction of C11ORF74 molecules can be transported towards the ciliary tip by associating with the IFT-A complex, although its majority might be out of cilia at steady state."
> "Q6NWV3-1","RefSeq","NP_112454.2","19000668","Studies on a complex A mutant mouse, defective for the Ift122 gene, is reported."
> "P57757-1","RefSeq","NP_112541.1","28465352","LAMP2A trafficking is regulated by cystinosin, Rab11, and RILP and that CMA up-regulation is a potential clinically relevant mechanism to increase cell survival in cystinosis."
> "P57757-1","RefSeq","NP_112541.1","26812160","Data indicate that hematopoietic stem cell (HSC) transplantation in cystinosin knockout (Ctns-/-) thyroid drastically decreased cystine accumulation and normalized the thyroid-stimulating hormone level."
> "P57757-1","RefSeq","NP_112541.1","17597652","Temporospatial pattern of cystine accumulation in Ctns-/- mice parallels that of patients and validates the mice as a model for the ocular anomalies of cystinosis. Erratum:[Pediatr Res. 2007 Nov;62(5):558]"
> "P57757-1","RefSeq","NP_112541.1","12370309","CTNS has a role in proper functioning of the retina and bones, and in mouse behavior"
> "Q9QZ15-1","RefSeq","NP_036129.1","28127756","This study shows that upon injection of d-galactosamine and lipopolysaccharide, Dcir1-/- mice show decreased mortality rates and serum levels of alanine aminotransferase"
> "Q9QZ15-1","RefSeq","NP_036129.1","28069953","DCIR modulates immunity to M. tuberculosis through sustaining type I IFN signaling in DCs, which reduces IL-12-p70 production and Th1 expansion. As a consequence, DCIR-deficient mice control M. tuberculosis infection better than their WT counterparts but also develop more immunopathology in the lungs."
> "Q9QZ15-1","RefSeq","NP_036129.1","26431873","While DCIR1 was ubiquitously expressed on myeloid cells in various immune organs, significant expression of DCAR2 was detected only on subpopulations of conventional dendritic cells from bone marrow and skin-draining lymph nodes."
> "Q9QZ15-1","RefSeq","NP_036129.1","26497661","Dcir1 enhances the pathogenesis of DSS colitis by altering neutrophil recruitment and their functions. Publication Status: Online-Only"
> "Q9QZ15-1","RefSeq","NP_036129.1","25926676","Our findings show that DCIR plays an important role in maintaining bone homeostasis."
> "Q9QZ15-1","RefSeq","NP_036129.1","18204462","These observations indicate that Dcir is a negative regulator of dendritic cell expansion and has a crucial role in maintaining the homeostasis of the immune system."
8748a11682,11685
> "O09100-1","RefSeq","NP_032116.4","30088690","Enforced expression of Gata2 in embryonic stem cells-derived hemogenic endothelial cells enhances erythroid and megakaryocyte differentiation and inhibits macrophage differentiation."
> "Q9Z2V9-1","RefSeq","NP_059063.2","25500740","Subcellular localization of Cdk5 is determined by its specific activators, cyclin I and p35."
> "Q9Z2V9-1","RefSeq","NP_059063.2","22262481","Both cyclin I and p35 are required for maximal survival benefit of cyclin-dependent kinase 5 in kidney podocytes."
> "Q9Z2V9-1","RefSeq","NP_059063.2","16847066","Cyclin I protects podocytes from apoptosis, and we provide preliminary data to suggest that this is mediated by stabilization of p21(Cip1/Waf1)."
8751a11689,11691
> "E9Q8Q6-1","RefSeq","NP_001020747.2","27737934","Findings showed that CAMDI regulates neuronal migration through the modulation of HDAC6 and indicate that HDAC6 hyperactivation by CAMDI deletion causes psychiatric behaviors, at least in part, through delayed radial migration due to impaired centrosomes"
> "E9Q8Q6-1","RefSeq","NP_001020747.2","27014940","Ccdc141 is expressed in GnRH neurons and olfactory fibers during embryonic development and that knockdown of Ccdc141 reduces GnRH neuronal migration."
> "E9Q8Q6-1","RefSeq","NP_001020747.2","20956536","CAMDI is required for radial migration probably through DISC1 and myosin II-mediated centrosome positioning during neuronal development."
8756a11697,11699
> "Q8BH69-1","RefSeq","NP_780609.4","27208177","Data found that several malignant characteristics of SPS1-deficient F9 cells were reversed, suggesting that SPS1 played a role in supporting and/or sustaining cancer. Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals."
> "Q8BH69-1","RefSeq","NP_780609.4","16262699","Murine and human solanesyl and decaprenyl diphosphate synthases are heterotetramers composed of newly characterized hDPS1 (mSPS1) and hDLP1 (mDLP1)"
> "Q8BGQ1-1","RefSeq","NP_598805.2","29409756","VPS33B and VIPAR are essential for epidermal lamellar body biogenesis and function"
8765a11709,11710
> "Q91X58-1","RefSeq","NP_081122.2","26876100","Study demonstrates specificity of AIRAPL for Lys48-linked tri-ubiquitin chains triggered by intrinsic selectivity of its double-sided UIM (UIM2) for Lys48 linkage and a flexible inter-UIM linker that results in an overall conformation which confers simultaneous binding of tUIMs to three consecutive ubiquitin moieties in a Lys48-linked chain."
> "Q91X58-1","RefSeq","NP_081122.2","26692333","AIRAPL-deficient mice develop a fully-penetrant myeloproliferative neoplastic process via dysregulation of IGF1/IGF1R."
8772a11718,11720
> "P30554-1","RefSeq","NP_032578.2","30121361","The reduction of ovulatory rate highlights the relevance of Ang-(1-7)/Mas axis in female reproduction, probably through a reduction of IGF-1 mRNA levels."
> "P30554-1","RefSeq","NP_032578.2","29138810","These results were supported by the opposite outcomes observed for cells treated with A779 or DX600. Therefore, it was concluded that the ACE2-Ang(17)-Mas axis significantly inhibits pancreatitis by inhibition of the p38 MAPK/NF-kappaB signaling pathway"
> "P30554-1","RefSeq","NP_032578.2","28254489","This study aimed to define whether sex chromosome complement (SCC) may differentially modulate sex differences in relative gene expression of basal Agtr1a, Agtr2, and Mas1 receptors at fore/hindbrain nuclei and at medulla/cortical kidney."
8779c11727
< "Q64516-3","RefSeq","NP_001281069.1","19546021","GK may have an apoptotic moonlighting role that is lost in glycerol kinase deficiency."
---
> "G5E904-1","RefSeq","NP_001094922.1","18725199","These results imply that these two amine-sulfonating SULT3s may play essential roles in the metabolism and detoxification of aromatic amine compounds in the body.(SULT3A2)"
8786a11735,11742
> "Q9Z2U4-1","RefSeq","NP_062654.2","24338897","Transcription factor ELF4 promotes development and function of memory CD8(+) T cells in Listeria monocytogenes infection."
> "Q9Z2U4-1","RefSeq","NP_062654.2","17167770","These findings suggest that MEF promotes cell proliferation and functions as a negative regulator of osteogenic differentiation by directly interacting with Runx2 and suppressing its transcriptional activity."
> "Q9Z2U4-1","RefSeq","NP_062654.2","12387738","MEF-/- mice have a profound reduction in the number of NK-T and NK cells"
> "Q78JN3-1","RefSeq","NP_081223.1","24344334","Eci3 specifically evolved in rodents after gene duplication of Eci2 and is localized to the peroxisomes GeneRIF: Mouse Eci3 is almost exclusively expressed in kidney."
> "P50096-1","RefSeq","NP_035959.2","17249559","IMPDH1 mutations cause photoreceptor degeneration in retinitis pigmentosa"
> "P50096-1","RefSeq","NP_035959.2","12944494","We conclude that both IMPDH and HPRT activities contribute to normal T-lymphocyte activation and function"
> "P50096-1","RefSeq","NP_035959.2","15180242","Retinitis pigmentosa-causing mutations identified in IMPDH1 gene. High level of IMPDH1 in photoreceptors, low levels in other layers of retina."
> "P50096-1","RefSeq","NP_035959.2","11875049","A mutation in this isozyme of Rho-/- mice was revealed in comparfative microarray analysis to be a homologue of the putative enzyme in human autosomal dominant retinitis pigmentosa."
8793d11748
< "Q80X50-1","RefSeq","NP_001159456.1","25185265","Two different BMI1-containing PcG complexes regulate hematopoietic stem cell activity, which are distinguishable by the presence of UBAP2L."
8794a11750,11755
> "Q7TNF0-1","RefSeq","NP_034199.1","29754754","Doc2alpha promoted glutamatergic spontaneous neurotransmitter release, while Doc2beta and syt1 both regulated GABAergic spontaneous neurotransmitter release."
> "Q7TNF0-1","RefSeq","NP_034199.1","25005332","Study identifies a critical role for DOC2B in insulin-stimulated glucose uptake in adipocytes, and for the synergistic regulation of GSIS by DOC2A and DOC2B in beta cells."
> "Q9R0G7-1","RefSeq","NP_056568.2","29922981","Our data not only suggest that Zeb2 is both necessary and sufficient for the differentiation of non-photoreceptor cell types while simultaneously inhibiting the photoreceptor cell fate by repressing transcription factor genes involved in photoreceptor specification and differentiation, but also reveal a necessity of Zeb2 in the long-term maintenance of retinal cell types."
> "Q9R0G7-1","RefSeq","NP_056568.2","30056076","In neurons from the Sip1 mice brainstem is suppressed by brief episodes of hypoxia. The mechanism responsible for this process is hypoxia-induced desensitization of the AMPA receptors, which is absent in the cortex neurons possessing the Sip1 mutation"
> "Q9R0G7-1","RefSeq","NP_056568.2","30076102","ZEB2 is critical for maintaining the tissue identities of macrophages. Loss of ZEB2 results in tissue-specific changes in different macrophage populations and their subsequent disappearance. In Kupffer cells, ZEB2 maintains LXRa expression, loss of which reproduces the change in Kupffer cell identity and their disappearance."
> "Q9R0G7-1","RefSeq","NP_056568.2","29449309","The transforming growth factor beta (TGF-beta) and miR-200 family members, which counterregulate the coordinated expression of Zeb1 and Zeb2 during the epithelial-to-mesenchymal transition, inversely regulated Zeb1 and Zeb2 expression in CD8(+) T cells."
8796a11758,11762
> "O08524-1","RefSeq","NP_033374.2","28935705","These results highlight the importance of the tectorin-based matrix and epithelial signals for precise collagen organisation in the tectorial membrane."
> "O08524-1","RefSeq","NP_033374.2","26806019","Alpha-tectorin and beta-tectorin crosslink type II collagen fibrils and connect the tectorial membrane to the spiral limbus."
> "O08848-1","RefSeq","NP_038863.1","30395870","Ro60 ameliorated the severity of dextran sodium sulfate -induced colitis in mice by repressing inflammation, fibrosis, angiogenesis, and the production of reactive oxygen species Erratum:[Immunol Lett. 2019 Jan 9;:. PMID: 30638737]"
> "O08848-1","RefSeq","NP_038863.1","25370295","These data support the hypothesis that antibodies to Ro274 deposit in salivary glands can enter intact salivary gland cells and are involved in the dysregulation of salivary flow in SS."
> "O08848-1","RefSeq","NP_038863.1","12121436","Restricted specificity of intermolecular spreading to endogenous La (SS-B) and 60 kDa Ro (SS-A) in experimental autoimmunity."
8798d11763
< "Q80TY0-1","RefSeq","NP_001171119.1","15252009","FBP17 interacts with dynamin and regulates endocytosis by forming vesicotubular structures."
8809c11774,11776
< "Q3TPJ7-1","RefSeq","NP_001334046.1","24187134","Midnolin plays a role in cellular signaling of adult tissues and regulates glucokinase enzyme activity in pancreatic beta cells"
---
> "O70475-1","RefSeq","NP_033492.1","24859727","Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 regulation: cytochrome CYP2A5, GSTM3, GSTM1, ENTPD5,UDPGDH, and EPHX1."
> "P97369-1","RefSeq","NP_032703.2","27543673","These studies demonstrate a critical role of phosphatidylinositol 3-phosphate-p40(phox) binding for optimal activation of the NADPH oxidase in macrophages."
> "P97369-1","RefSeq","NP_032703.2","27231144","Our data reveal a specific role for NCF4-mediated intracellular ROS production in regulating autoimmunity and chronic inflammation."
8814a11782,11786
> "Q9D4B1-1","RefSeq","NP_083219.2","30305392","2-Hydroxy-oleic acid inhibited rather than activated recombinant SMS1 (rSMS1) and rSMS2 in a dose-dependent fashion. Erratum:[J Biol Chem. 2019 May 31;294(22):8716. PMID: 31152097]"
> "Q9D4B1-1","RefSeq","NP_083219.2","29345004","SMS2 generates sphingomyelin in the epidermis and contributes to epidermal permeability barrier function"
> "Q9D4B1-1","RefSeq","NP_083219.2","28522594","These results demonstrate that SMS2 deficiency inhibits DSS-induced colitis and subsequent colitis-associated colon cancer via inhibition of colon epithelial cell-mediated inflammation; therefore, inhibition of SMS2 may be a potential therapeutic target for human colitis and colorectal cancer."
> "Q9D4B1-1","RefSeq","NP_083219.2","27840247","This study showed that MWM learning was deteriorated and associated with depression-like tendency in SMS2 KO mice."
> "Q9D4B1-1","RefSeq","NP_083219.2","18566297","SMS2 (Sphingomyelin synthase 2) physiologically contributes to de novo Sphingomyelin biosynthesis and plasma membrane Sphingomyelin levels"
8821a11794
> "P00184-1","RefSeq","NP_034122.1","29666456","These results suggest that intracellular accumulation of serotonin (5-HT) via SERT induces CYP1A1 expression via AhR in intestinal epithelial cells, and SERT deficiency in vivo impairs activation of AhR. Publication Status: Online-Only"
8828a11802,11808
> "A2AU37-1","RefSeq","NP_001263329.1","28239026","When ectopically expressed in somatic cells, can promote homologous chromosome adjacency, which resembles the homolog pairing normally seen during meiosis"
> "A2AU37-1","RefSeq","NP_001263329.1","27665783","These results strongly support the previous proposition that RAD21L is an atypical cohesin that establishes the association between homologs rather than sister chromatids."
> "A2AU37-1","RefSeq","NP_001263329.1","27792785","Super resolution microscopy revealed synapsis-associated SYCP1 aberrantly deposited between sister chromatids and on single chromatids in Smc1b-/-Rad21L-/- cells. Publication Status: Online-Only"
> "A2AU37-1","RefSeq","NP_001263329.1","21743440","These results provide in vivo evidence that RAD21L is essential for male fertility and in females for the maintenance of fertility during natural aging. Publication Status: Online-Only"
> "A2AU37-1","RefSeq","NP_001263329.1","21527826","RAD21L is identified as a novel subunit of the cohesin complex with homology to the RAD21/REC8/alpha-kleisin subfamily expressed in mouse testis."
> "A2AU37-1","RefSeq","NP_001263329.1","21274006","Study identifes a new mammalian cohesin subunit, RAD21L, with sequence similarity to RAD21 and REC8; RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21"
> "A2AU37-1","RefSeq","NP_001263329.1","21242291","The results suggest that cohesin complexes containing RAD21L may be involved in synapsis initiation and crossover recombination between homologous chromosomes."
8830a11811,11813
> "Q99K48-1","RefSeq","NP_075633.2","29673854","Nono overexpression increased the expression of pro-inflammatory cytokines leading to increased atherosclerotic plaque formation."
> "Q99K48-1","RefSeq","NP_075633.2","29358041","NONO post-transcriptionally coordinates circadian mRNA expression of metabolic genes with the feeding/fasting cycle, thereby playing a critical role in energy homeostasis."
> "Q99K48-1","RefSeq","NP_075633.2","28209515","NONO deficiency significantly compromises the response to ionizing radiation-induced DNA damage in the testes, consistent with cell type-specific loss of DSB repair capacity. The results provide evidence that this RNA binding protein significantly contributes to the DNA damage response in vivo."
8836,8842c11819,11820
< "Q8K558-1","RefSeq","NP_001276386.1","30282800","Findings suggest that TLT-1 uses fibrinogen to govern the transition between inflammation and hemostasis and facilitate controlled leukocyte transmigration during the progression of ARDS."
< "Q8K558-1","RefSeq","NP_001276386.1","30120105","TREM-like transcript 1: a more sensitive marker of platelet activation than P-selectin in humans and mice."
< "Q8K558-1","RefSeq","NP_001276386.1","22761415","TLT-1s, alternative transcripts of triggering receptor expressed on myeloid cell-like transcript-1 (TLT-1), Inhibits the triggering receptor expressed on myeloid cell-2 (TREM-2)-mediated signaling pathway during osteoclastogenesis."
< "Q8K558-1","RefSeq","NP_001276386.1","19436112","TLT-1 plays a protective role during inflammation by dampening the inflammatory response and facilitating platelet aggregation at sites of vascular injury"
< "Q8K558-1","RefSeq","NP_001276386.1","16505478","A soluble fragment of the TLT-1 extracellular domain is found in serum of humans and mice and that an isoform of similar mass is released from platelets following activation with thrombin."
< "Q8K558-1","RefSeq","NP_001276386.1","15100151","Expressed exclusively in platelets and megakaryocytes; expression is up-regulated upon platelet activation; is prepackaged into both MK and platelet alpha-granules; may regulate granule construction or dispersal"
< "Q8K558-1","RefSeq","NP_001276386.1","12393607","Initial characterization of TREM-like transcript (TLT)-1; results indicate it is likely that TLT-1 regulates the signaling of the TREM family receptors"
---
> "Q99KB8-1","RefSeq","NP_077246.2","31049129","Hyperosmotic stress induced AMPK activation, but this was not responsible for its effects on mTOR activity or autophagy induction. Moreover, the decrease in Trx1 and Glo2 induced by hyperosmotic stress was independent of both autophagy and AMPK activation. Publication Status: Online-Only"
> "Q99KB8-1","RefSeq","NP_077246.2","24252591","Glyoxalase expression prevents against ischemic neuronal cell damage and ameliorates ischemic injury."
8846a11825,11826
> "P06804-1","RefSeq","NP_038721.1","31049124","Investigation of 2-AP demonstrated its nociception inhibition and ability to reduce reactive oxygen species. Its interaction with A2a receptors may well be related to proinflammatory cytokines TNF-alpha and IL-1beta reduction activity, corroborating its antinociceptive effect. Publication Status: Online-Only"
> "P06804-1","RefSeq","NP_038721.1","20194223","The authors summarize the biological activities exerted by different products generated from cleavage of the human TNF. Review article"
8860a11841,11842
> "P47941-1","RefSeq","NP_031790.2","29360039","Here, we show that the Crk family of adaptor proteins, Crk and Crkl, are required for mouse lens morphogenesis but not differentiation upon Fibroblast Growth Factor stimulation. Publication Status: Online-Only"
> "P47941-1","RefSeq","NP_031790.2","11242111","Crkol is essential for cranial and cardiac neural crest development. The chromosomal location of the human CRKL gene (22q11.21) and the phenotype of Crkol mutant mice suggest that defects in CRKL-mediated pathways underlie DiGeorge syndrome."
8866a11849,11850
> "Q8R3L2-1","RefSeq","NP_080080.2","12107429","The complex expression pattern and unique protein sequence, including an acidic amino terminal and putative transcription activation domain, suggests that Nulp1 may have a distinct role in embryonic development of many organs, including the adult brain."
> "Q80T91-1","RefSeq","NP_766110.3","22407321","In mouse, two related transmembrane proteins, MEGF10 and MEGF11, have critical roles in the formation of mosaics by two retinal interneuron subtypes, starburst amacrine cells and horizontal cells Publication Status: Online-Only"
8868a11853,11854
> "Q80XI6-1","RefSeq","NP_071295.2","28262979","In lipotoxic hepatocytes, MLK3 activates a MAPK signaling cascade, resulting in the activating phosphorylation of STAT1, and CXCL10 transcriptional upregulation."
> "Q80XI6-1","RefSeq","NP_071295.2","26406121","During hepatocyte lipotoxicity, activated MLK3 induces the release of CXCL10-bearing vesicles from hepatocytes, which are chemotactic for macrophages. Erratum:[Hepatology. 2016 Aug;64(2):702. PMID: 27442762]"
8877a11864,11869
> "Q06985-1","RefSeq","NP_033199.1","21109632","Findings define a Siah-Pard3A signaling pathway that controls adhesion-dependent exit of neuronal progenitors or immature neurons from a germinal zone niche"
> "Q06985-1","RefSeq","NP_033199.1","16230351","Siah1 is a binding partner for POSH (plenty of SH3s), a scaffold component of the apoptotic JNK pathway"
> "Q06985-1","RefSeq","NP_033199.1","12417719","Results from loss-of-function experiments do not support a general role for Siah genes in p53-mediated responses or mitosis."
> "Q99JR5-1","RefSeq","NP_075965.2","26522507","Tinagl1 is related to fertility in adult females but is not essential for either fertilization or preimplantation development in vitro"
> "Q99JR5-1","RefSeq","NP_075965.2","19587330","In mouse embryos, the expression of both Tinagl1 mRNA and TINAGL1 protein was increased just prior to implantation. During postimplantation, TINAGL1 expression was restricted to extraembryonic regions."
> "Q99JR5-1","RefSeq","NP_075965.2","17425658","Collectively with the putative role of AZ-1 in the adrenocortical zonation, we propose that AZ-1 potentially regulates functions of adrenocortical and VSM cells by modulating cell-matrix interactions"
8881a11874
> "Q9D552-1","RefSeq","NP_083343.1","16395525","Flow cytometry analysis showed that the expression of Spata17 protein in the GC-1 cell line could accelerate GC-1 cell apoptosis [Spata17]"
8886a11880,11881
> "Q9DCG2-1","RefSeq","NP_079698.2","27316686","These studies confirm a functional role for CD302 in myeloid dendritic cells migration."
> "Q9DCG2-1","RefSeq","NP_079698.2","17947679","HDCL-1 is an unconventional lectin receptor that plays roles not only in endocytosis/phagocytosis but also in cell adhesion and migration"
8889a11885,11891
> "Q8CFW1-1","RefSeq","NP_705817.2","28536821","Results of behavioral studies obtained from Ano2 (-/-) mice, a mouse line that was previously shown to lack this particular mode of ionic plasticity. The animals display motor coordination deficits that constitute a condition of mild ataxia. Moreover, motor learning is severely impaired in Ano2 (-/-) mice, suggesting cerebellar dysfunction."
> "Q8CFW1-1","RefSeq","NP_705817.2","28858616","Loss of TMEM16B expression resulted in the absence of Calcium-activated Chloride channels in inferior Olive neurons, leading to markedly diminished action potential firing of IO neurons. TMEM16B knockout mice. Moreover, exhibited severe cerebellar motor learning deficits."
> "Q8CFW1-1","RefSeq","NP_705817.2","28784854","Results suggest that the anoctamin 2-mediated amplification mechanism enables mice to track weak, unfamiliar olfactory cues."
> "Q8CFW1-1","RefSeq","NP_705817.2","19475416","Our results demonstrate that mTMEM16B functions as a Ca(2+)-activated Cl(-) channel when expressed in HEK 293T cells."
> "Q8CFW1-1","RefSeq","NP_705817.2","19561302","ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification. GeneRIF: Ano2 likely amplifies the odor-induced generator potential in olfactory sensory neuron cilia by sensing elevated calcium levels, permitting the outward flow of chloride ions from the cell."
> "Q8CFW1-1","RefSeq","NP_705817.2","19474308","TMEM16B is lost from photoreceptor membranes of MPP4-deficient mice"
> "Q8CFW1-1","RefSeq","NP_705817.2","18729231","Data show the expression of Tmem16b during murine embryogenesis with an emphasis on the respiratory, digestive, skeletal, and integumentary systems."
8907a11910,11913
> "Q924M5-1","RefSeq","NP_083543.2","27632217","Asked whether BOULE, the founding member of DAZ family proteins, is a component of the SGs. We show that BOULE is recruited to the SGs upon heat stress, and that these SGs are developmental stage-specific Publication Status: Online-Only"
> "Q924M5-1","RefSeq","NP_083543.2","25726377","These results showed that IGF1 regulated the expression of BOULE and CDC25A mRNAs via ERK1/2 signaling and in T-independent pathway during spermatogenesis in the adult mouse testes."
> "Q924M5-1","RefSeq","NP_083543.2","24086306","Demonstrate that Boll is also transiently expressed during oogenesis in the fetal mouse ovary, but is simultaneously co-expressed within the same germ cells as Dazl Erratum:[PLoS One. 2015;10(8):e0136009. PMID: 26270527] Publication Status: Online-Only"
> "Q924M5-1","RefSeq","NP_083543.2","20335278","Expression of key regulators of spermiogenesis was unaffected in Boule(-/-) mice, suggesting that Boule regulates germ-cell differentiation through a novel pathway."
8913,8916d11918
< "Q8BH75-1","RefSeq","NP_001157709.1","26390156","Data suggest that ring finger protein 41 Nrdp1 terminates T cell antigen receptors (TCRs) signaling by inactivating Zap70 kinase."
< "Q8BH75-1","RefSeq","NP_001157709.1","26085571","The novel Pdx1-Clec16a-Nrdp1 pathway this study describes provides a genetic basis for the pathogenesis of mitochondrial dysfunction in multiple forms of diabetes."
< "Q8BH75-1","RefSeq","NP_001157709.1","22707723","Demonstrate that Nrdp1-mediated ubiquitination and activation of C/EBPbeta contributes to a ubiquitin-dependent nonproteolytic pathway that up-regulates Arg1 expression and promotes M2 macrophage polarization"
< "Q8BH75-1","RefSeq","NP_001157709.1","21738612","Nrdp1 may be a key mediator in the development of cardiac dysfunction after DOX treatment and associated with inhibition of Akt, ERK1/2 and STAT3."
8934a11937,11940
> "Q60935-1","RefSeq","NP_033840.2","28138708","The results demonstrated that ART1 gene silencing inhibited the growth of the spleen transplanted tumor and its ability to spread to the liver via metastasis."
> "Q60935-1","RefSeq","NP_033840.2","26847718","Data suggest that ART1 promoted the expression of HIF-1alpha via the Akt pathway in tumor cells."
> "Q60935-1","RefSeq","NP_033840.2","24676941","The apoptosis rate in the ART1-cDNA CT26 cells treated with PARP-1 inhibitor 5-aminoisoquinoline (5-AIQ) and cisplatin increased, when compared with the ART1-cDNA CT26 cells treated with cisplatin only or the untreated ART1-cDNA CT26 cells."
> "Q60935-1","RefSeq","NP_033840.2","24335275","ART1 knockdown reduced survival rate correlated with reduced levels of phos-Akt(Thr308) and phos-IkappaBalpha and reduced NF-kappaB p65 nuclear translocation."
8940a11947
> "Q9CXJ4-1","RefSeq","NP_083296.2","22375032","These results indicate that ABCB8 is essential for normal cardiac function, maintenance of mitochondrial iron homeostasis and maturation of cytosolic Fe/S proteins."
8950a11958,11961
> "Q924A2-4","RefSeq","NP_082158.2","31043608","These results identify Cic as an important regulator of cell fate in neurodevelopment and oligodendroglioma, and suggest that its loss contributes to oligodendroglioma by promoting proliferation and an oligodendrocyte precursor cells -like identity via Ets overactivity. Publication Status: Online-Only"
> "Q924A2-4","RefSeq","NP_082158.2","29844126","CIC is a transcriptional repressor of genes regulated by MAPK signaling."
> "Q924A2-4","RefSeq","NP_082158.2","29382756","Loss of CIC causes T cell lymphoblastic leukemia/lymphoma."
> "Q924A2-4","RefSeq","NP_082158.2","12393275","Results describe the identification and characterization of a new gene, Cic, in both human and mouse genomes, that is implicated in granule cell development."
8953a11965,11968
> "P70662-1","RefSeq","NP_034827.1","31127120","Study identifies Pax3 interaction with members of the chromatin looping complex, including the LIM-domain binding protein 1 (Ldb1) and demonstrates that Ldb1 is recruited to a subset of Pax3-bound elements characterized by increased levels of H3K4me1 deposition. Reduced Ldb1 expression impairs Pax3-dependent myogenic specification both in vitro and in vivo. Publication Status: Online-Only"
> "P70662-1","RefSeq","NP_034827.1","30873428","Loss of Ldb1 from E8.75 using Foxg1Cre caused a disruption of midline boundary structures in the dorsal telencephalon. While this Cre line gave the expected pattern of recombination of the floxed Ldb1 locus, unexpectedly, standard Cre lines that act from embryonic day (E)10.5 (Emx1Cre) and E11.5 (NesCre) did not show efficient or complete recombination in the dorsal telencephalon by E12.5. Publication Status: Online-Only"
> "P70662-1","RefSeq","NP_034827.1","30626972","Greek-island-bound transcription factor LHX2 and adaptor protein LDB1 regulate the assembly and maintenance of olfactory receptor compartments, Greek island hubs and olfactory receptor transcription, providing mechanistic insights into and functional support for the role of trans interactions in gene expression"
> "P70662-1","RefSeq","NP_034827.1","16815859","Mouse Ldb1b lacks the ability to activate protein 4.2 promoter, which is stimulated by LMO2 and Ldb1. These findings suggest that splice isoforms of Ldb lacking LID are potential regulators of Ldb function.[lbd1]"
8958,8961d11972
< "Q14AX6-1","RefSeq","NP_001103096.1","30487607","CDK12 regulates DNA repair genes by suppressing intronic polyadenylation; work clarifies the function of CDK12 and underscores its potential both as a chemotherapeutic target and as a tumour biomarker"
< "Q14AX6-1","RefSeq","NP_001103096.1","27073218","Report on the functions of Cdk12 during neural development in vivo, proposes a dual role for Cdk12 in neurogenesis and late stage neuronal migration via 2 distinct pathways"
< "Q14AX6-1","RefSeq","NP_001103096.1","26658019","Spontaneous DNA damage was revealed by an increase in 53BP1 foci among cells cultured from Cdk12(-/-) embryos."
< "Q14AX6-1","RefSeq","NP_001103096.1","24999027","The findings of this study suggest that Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression."
8983d11993
< "Q9JI90-1","RefSeq","NP_001158093.1","24472305","RNF14 influences the expression of both mitochondrial and immune related genes Publication Status: Online-Only"
8997a12008,12012
> "P49935-1","RefSeq","NP_031827.2","29470604","CatH deficiency impaired toll-like receptor 3-mediated activation of interferon regulatory factor 3 and consequent secretion of IFN-beta"
> "P49935-1","RefSeq","NP_031827.2","24982147","The data provide strong evidence that CTSH is an important regulator of beta-cell function during progression of T1D"
> "Q61624-1","RefSeq","NP_035879.1","29242385","Data indicate zinc finger protein 148 (ZFP148) as a transcription factor that differentially binds to the zinc finger protein 30 protein (Zfp30) promoter region harboring rs51434084. Publication Status: Online-Only"
> "Q61624-1","RefSeq","NP_035879.1","28247213","Study demonstrated that miR-20b suppressed ZFP-148 expression by directly binding to the 3'-UTR of target mRNA and repressed translation at posttranscriptional level during virus myocarditis."
> "Q61624-1","RefSeq","NP_035879.1","27487143","The results suggest that Zfp148 controls the fate of newly transformed intestinal tumor cells by repressing p53 and that targeting Zfp148 might be useful in the treatment of colorectal cancer."
8999,9000c12014
< "P58269-1","RefSeq","NP_001254554.1","30824325","Lnc-Dpf3 directly bound to HIF-1alpha."
< "P58269-1","RefSeq","NP_001254554.1","18765789","DPF3 adds a further layer of complexity to the BAF complex by representing a tissue-specific anchor between histone acetylations as well as methylations and chromatin remodeling."
---
> "Q80Y74-1","RefSeq","NP_808299.1","26930067","Data show that gametocyte specific factor 1-like Gtsf1l and Gtsf2 (BC048502) protein were sequentially but not simultaneously expressed in gonocytes and spermatids. Publication Status: Online-Only"
9011a12026,12029
> "P58735-1","RefSeq","NP_777359.3","26671068","Slc26a1, Slc26a6 and Slc26a7 are novel participants in the extracellular transport of bicarbonate during enamel maturation. Publication Status: Online-Only"
> "P58735-1","RefSeq","NP_777359.3","22517357","Study concludes that a DIDS-sensitive basolateral transporter is involved in mediating oxalate secretion across mouse duodenum, but Sat1 itself is dispensable for this process"
> "P58735-1","RefSeq","NP_777359.3","20160351","Sat1 regulates both oxalate and sulfate homeostasis and may be critical to the development of calcium oxalate urolithiasis and hepatotoxicity."
> "P58735-1","RefSeq","NP_777359.3","12590734","First characterization of the structure and regulation of the Sat1 gene encoding a SO(4)(2-)/chloride/oxalate anion transporter"
9018a12037,12041
> "P30681-1","RefSeq","NP_032278.1","30538136","A novel RAG1 mutation reveals a critical in vivo role for HMGB1/2 during V(D)J recombination."
> "P30681-1","RefSeq","NP_032278.1","29942000","The enhance expression of HMGB2 induces the adipogenesis of MSCs and the fat infiltration into skeletal muscles through the cascade of HMGB2-PDGFRA Publication Status: Online-Only"
> "P30681-1","RefSeq","NP_032278.1","28771884","HMGB2 expression is strongly associated with transition from the quiescent to the proliferative state of neural stem cells, supporting the possibility that HMGB2 is involved in the regulation of adult neurogenesis and can be used as a novel marker to identify neural stem cells primed for activation in the adult hippocampus."
> "P30681-1","RefSeq","NP_032278.1","28183701","HMGB2 promoted neointimal hyperplasia in mice with arterial wire injury through reactive oxygen species activation."
> "Q3UHK6-1","RefSeq","NP_035988.2","26013034","Our findings revealed that Ten-4 functions as a crucial player in maintaining the quiescence of muscle satellite cells"
9027a12051,12057
> "Q9JL10-1","RefSeq","NP_061290.1","27494853","Met has a role in promoting formation of double minute chromosomes induced by Sei-1 in NIH-3T3 murine fibroblasts"
> "Q9JL10-1","RefSeq","NP_061290.1","24211589","These data suggest that SERTAD1 acts as a SMAD1 transcriptional co-activator to promote the expression of BMP target genes during mouse cardiogenesis."
> "Q9JL10-1","RefSeq","NP_061290.1","20237268","Sertad1 expression is required is required for developmental neuronal death in the cerebral cortex."
> "Q9JL10-1","RefSeq","NP_061290.1","20090907","Conclude that Sei1 plays an important role in pancreatic beta-cells, which supports a functional link between Sei1 and the core cell cycle regulators specifically in the context of the pancreas Publication Status: Online-Only"
> "Q8BLI4-1","RefSeq","NP_766096.1","26488883","Data show that dermatan sulfate is completely absent in dermatan sulfate epimerase 1 and 2 double knockout (DKO) mice. Publication Status: Online-Only"
> "Q8BLI4-1","RefSeq","NP_766096.1","25186462","The combination of defective collagen structure in the dermis and imbalanced keratinocyte maturation could be responsible for the observed developmental defects in DS-epi1-deficient mice."
> "Q8BLI4-1","RefSeq","NP_766096.1","19687302","DS-epi1-deficient mice show chondroitin sulfate /dermatan sulfate with a marked deficiency in iduronic acid-containing structures."
9030,9032c12060,12066
< "Q3UHD6-1","RefSeq","NP_001075953.1","29180720","This study broadens our understanding of SNX27 as an integrator of lipid-based signals with the control of transcription and metabolic pathways. Publication Status: Online-Only"
< "Q3UHD6-1","RefSeq","NP_001075953.1","27974614","We anticipate that future study will determine whether modulation of a SNX27/Notch/gamma-secretase pathway can also be of therapeutic interest to congenital hydrocephalus"
< "Q3UHD6-1","RefSeq","NP_001075953.1","15466885","SNX27 and NHERF specifically interact with the 5-HT4a receptor splice variant"
---
> "Q99LG2-1","RefSeq","NP_663365.3","28777795","Essential for Hedgehog pathway activation; mediates ciliary translocation of Gli proteins Publication Status: Online-Only"
> "Q99LG2-1","RefSeq","NP_663365.3","17475777","Early in muscle differentiation, HuR is localized to the nucleus of myoblasts by active Transportin 2 (TRN2)-mediated import."
> "Q8BKH7-1","RefSeq","NP_796319.1","30571167","Sin1 is an amplifier of platelet alphaIIbbeta3-mediated outsidein signaling and a susceptible sensor of hypoxia/ROS signaling in ischemic environments after myocardial infarction, inducing microthrombosis."
> "Q8BKH7-1","RefSeq","NP_796319.1","28692058","In colorectal cancer tissues, the Sin1 protein but not mRNA was significantly upregulated while Pdcd4 protein was downregulated, suggesting that loss of Pdcd4 might correlate with Sin1 protein level but not mRNA level in colorectal cancer."
> "Q8BKH7-1","RefSeq","NP_796319.1","28174303","This study provides evidence that Sin1, a known element of the mammalian target of rapamycin complex 2 (mTORC2), is required for Interferon-gamma-induced phosphorylation and activation of AKT and that such activation mediates downstream regulation of mTORC1 and its effectors."
> "Q8BKH7-1","RefSeq","NP_796319.1","17043309","Sin1 together with Rictor are key components of mTORC2 and play an essential role in Akt phosphorylation and signaling"
> "Q8BKH7-1","RefSeq","NP_796319.1","16962653","Results reveal that the SIN1-rictor-mTOR function in Akt-Ser473 phosphorylation is required for TORC2 function in cell survival but is dispensable for TORC1 function."
9065a12100,12105
> "P47936-1","RefSeq","NP_034054.3","31532239","A number of studies in animal models have shown the efficacy of cannabinoid receptor 2 agonists in limiting inflammation in a range of preclinical models of inflammation, including colitis, atherosclerosis, multiple sclerosis, and ischemia-reperfusion injury. (Review) Review article"
> "P47936-1","RefSeq","NP_034054.3","30952618","Our results suggest that CB2Rs modulate VTA DA neuron excitability mainly through an intrinsic mechanism, including a CB2R-mediated reduction of intracellular cAMP, and in turn enhancement of M-type K(+) currents."
> "P47936-1","RefSeq","NP_034054.3","30508607","The results of this study shown that CB2Rs expressed in dopaminergic neurons participate in the locomotor and differential rewarding properties of the selected psychostimulants."
> "P47936-1","RefSeq","NP_034054.3","30403990","After occlusion of left pulmonary artery, CB2 receptor seems to modulate right ventricular adaptation through expression of contractile elements, reactive oxygen scavenger enzymes, and inflammatory response in order to prevent cardiomyocyte apoptosis."
> "P47936-1","RefSeq","NP_034054.3","19757078","Resting splenic B cells in mice use multiple transcript start sites and express at least three CB2 transcript variants."
> "Q8C6S9-1","RefSeq","NP_001333989.1","26224312","This study identifies a critical role for CFAP54 in proper assembly and function of mammalian cilia and flagella and establishes the gene-trapped allele as a new model of PCD"
9071a12112,12117
> "Q80TJ1-1","RefSeq","NP_036191.2","28883501","Together, these data show that the CAPS-1 C-terminus regulates synaptic enrichment of CAPS-1. All CAPS-1 functional domains are required, and the C2 and PH domain together are not sufficient, for dense core vesicles exocytosis in mammalian central nervous system neurons. Publication Status: Online-Only"
> "Q80TJ1-1","RefSeq","NP_036191.2","16506193","The two CAPS family proteins are complementarily distributed throughout the various brain regions of mice."
> "Q9JHL0-1","RefSeq","NP_075253.2","25153696","NTAL is a negative regulator of FcepsilonRI activation events in murine bone marrow-derived mast cells, independently of possible compensatory developmental alterations. Publication Status: Online-Only"
> "Q9JHL0-1","RefSeq","NP_075253.2","24819605","Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation. Publication Status: Online-Only"
> "Q9JHL0-1","RefSeq","NP_075253.2","23675302","Our data define a novel link between LAB and beta-catenin nuclear accumulation in dendritic cells that facilitates IFN-gamma responses during anti-fungal immunity"
> "Q9JHL0-1","RefSeq","NP_075253.2","15477348","NTAL negatively regulates Fc-epsilon receptor I-mediated signaling events in bone marrow-derived mast cells."
9075,9079d12120
< "Q149L7-1","RefSeq","NP_001268883.1","26694968","These results reveal that CRTAM is critical to instruct the differentiation of CD4(+)CTL through the induction of Eomes and CTL-related gene."
< "Q149L7-1","RefSeq","NP_001268883.1","24687959","During pathogenic infection, Crtam-Cadm1 interactions regulate the dynamic equilibrium between newly formed CD4(+) T cells and their retention in the gut."
< "Q149L7-1","RefSeq","NP_001268883.1","21572449","TCS upregulated the expression of tumor suppressor in lung cancer 1 (TSLC1) in 3LL tumor cells and the expression of its ligand, class I-restricted T cell-associated molecule (CRTAM), in effector T cells."
< "Q149L7-1","RefSeq","NP_001268883.1","15811952","NK cells and T8 cells recognize Necl-2 through CRTAM, expressed only on activated cells. CRTAM-Necl-2 interactions promote cytotoxicity of NK cells and IFN-gamma secretion of T8 cells as well as NK cell-mediated rejection of tumors expressing Necl-2"
< "Q149L7-1","RefSeq","NP_001268883.1","15781451","Necl2/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system"
9085a12127,12131
> "Q91Y74-1","RefSeq","NP_033204.2","25066807","The results of this study indicated that ST3Gal IV is a key molecule in the mechanisms underlying anxiety - a side effect of TLE - and may therefore also be an effective target for treating epilepsy, acting through the same circuits."
> "Q91Y74-1","RefSeq","NP_033204.2","12097641","Operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands"
> "Q8K4X7-1","RefSeq","NP_080920.2","29627383","Study utilizing Lpaat-delta deficient mice identify an important role for murine Lpaat-delta in musculus soleus and extensor digitorum longus contractile force generation."
> "Q8K4X7-1","RefSeq","NP_080920.2","28807933","Findings indicate that Lpaatdelta deficiency causes deficits in learning and memory associated with reduced NMDA and AMPA receptors. Publication Status: Online-Only"
> "Q8K4X7-1","RefSeq","NP_080920.2","28814640","Agpat4/Lpaatdelta deficiency highlights the molecular heterogeneity of epididymal and perirenal white adipose depots"
9102a12149
> "O89110-1","RefSeq","NP_033942.1","30598363","Polo-like kinase 1 is recruited into mitotic ripoptosomes, where PLK1's activity is controlled via RIPK1-dependent recruitment and Caspase-8-mediated cleavage, ensuring chromosome stability and faithful chromosome segregation during mitosis."
9105a12153,12159
> "Q9Z1N5-1","RefSeq","NP_062667.1","29164525","Ectopic UAP56 upregulated HSF4-controlled HSP25 and alpha B-crystallin proteins expression, while knocking down UAP56 by shRNA reversed it."
> "Q9Z1N5-1","RefSeq","NP_062667.1","24618812","These results imply that murine leukemia virus requires UAP56, THOC5 and THOC7, in addition to NXF1, for nuclear export of viral transcripts. Publication Status: Online-Only"
> "P97465-1","RefSeq","NP_034200.4","29548825","Findings demonstrate that Dok-3 and Dok-1/-2 play distinctive but cooperative roles in osteoclastogenesis and protect mice from osteopenia, providing physiological and pathophysiological insight into bone homeostasis."
> "P97465-1","RefSeq","NP_034200.4","28490594","Thus, Dok-1 and Dok-2 promote survival of glycoprotein B-specific CD8(+) T cells in trigeminal ganglia latently infected with herpes simplex virus 1. Publication Status: Online-Only"
> "P97465-1","RefSeq","NP_034200.4","27926878","In the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells."
> "P97465-1","RefSeq","NP_034200.4","27664281","These results reveal the critical involvement of Dok-1 and Dok-2 in a negative-feedback loop that prevents overactivation of CD8(+) T cells and promotes memory formation."
> "P97465-1","RefSeq","NP_034200.4","27450811","Taken together, our results demonstrate that Dok-1 and Dok-2 negatively regulate intestinal inflammation, apparently through the induction of IL-17A and IL-22 expression."
9115a12170,12172
> "P59096-1","RefSeq","NP_083295.1","18211099","StARD6, which is expressed only in male germ-line cells, thus exhibits biological and biophysical properties that imply a role in steroidogenesis."
> "Q5DTY9-1","RefSeq","NP_080411.1","27717812","This study demonstrated that the Kctd16(-/-) mice exhibited less extinction of auditory fear memory relative to WT and Kctd16(+/-) mice, as well as more contextual fear memory relative to WT and, in particular, Kctd16(+/-) mice."
> "Q5DTY9-1","RefSeq","NP_080411.1","21452234","Data suggest that the distinct spatial and temporal distribution patterns of KCTD8, 12, 12b, and 16 underlie functional differences in native GABA(B) responses."
9120c12177,12183
< "Q7TSC3-1","RefSeq","NP_001334247.1","23727203","Nek5 promotes myogenic differentiation through up-regulation of caspase-3 activity."
---
> "Q6P902-1","RefSeq","NP_705739.2","23707457","Txndc2 and Txndc3 are critically important in protecting spermatozoa against the increases in oxidative stress associated with paternal age."
> "Q8R317-1","RefSeq","NP_689420.1","31059032","The results of this study revealed that hypoxia-ischemic decreased the expression of Ubqln, thus may provide a novel understanding of role of Ubqln in neonatal hypoxic ischemic encephalopathy."
> "Q8R317-1","RefSeq","NP_689420.1","27928652","Post-ischemic overexpression of Ubqln1 significantly promoted functional recovery."
> "Q8R317-1","RefSeq","NP_689420.1","28420763","Reduced body weight gain in mice, overexpressing Ubqln1 was associated with upregulation of SIRT1 and AMPK."
> "Q8R317-1","RefSeq","NP_689420.1","28598849","This study provide strong evidence showing that Ubqln1 plays a crucial role in modulating learning and memory function in different cohorts of transgenic mice."
> "Q8R317-1","RefSeq","NP_689420.1","19148225","UBQLN1-transfected cells did not show increased starvation-induced cell death"
> "Q8R317-1","RefSeq","NP_689420.1","15004330","Described results suggest that ubiquilin proteins play an important role in regulating presenilin 2 (PS2) protein levels in cells."
9125,9133c12188
< "Q8BR86-1","RefSeq","NP_001177840.1","29362445","Findings provide evidence that Kirrel3(-/-) mice exhibit autistic-like behaviors, including social and communicative deficits, repetitive behaviors, and sensory abnormalities, as well as hyperactivity. Publication Status: Online-Only"
< "Q8BR86-1","RefSeq","NP_001177840.1","28815295","The results of this study demonstrate that Kirrel2 and Kirrel3 are essential for the formation of glomeruli and suggest they contribute to synaptogenesis in the accessory olfactory bulb."
< "Q8BR86-1","RefSeq","NP_001177840.1","28670619","This study demonstrated that selective loss of mossy fiber filopodial synapses with GABA neurons likely underlies the hippocampal activity imbalance observed in Kirrel3 knockout mice and may impact neural function in patients with Kirrel3-dependent neurodevelopmental disorders. Publication Status: Online-Only"
< "Q8BR86-1","RefSeq","NP_001177840.1","28621431","Mouse Kirrel3 is a myobast adhesion molecule which promotes the morphological change of rounded MPC to a spindle shaped myocyte that migrates in a directed fashion and participates in the tight interactions between myocytes prior to their fusion"
< "Q8BR86-1","RefSeq","NP_001177840.1","18752272","Results suggest that Kirrel3 plays a role in the axonal pathfinding, cell recognition, and synapse formation of DRG neurons on target cells, including the targeting of proprioceptive neurons on muscle spindles through the interaction with nephrin."
< "Q8BR86-1","RefSeq","NP_001177840.1","18022324","These results suggest that mKirre may be involved in the establishment of the pathway from sensory organs to the brain."
< "Q8BR86-1","RefSeq","NP_001177840.1","16874800","In the adult brain, Neph2 is seen in the olfactory nerve layer and the glomerular layer of the olfactory bulb, in the hippocampus, and in cerebellar Purkinje cells. At the ultrastructural level, Neph2 is seen in dendritic shafts of pyramidal neurons."
< "Q8BR86-1","RefSeq","NP_001177840.1","15908127","The spatiotemporal expression pattern of mKirre mRNA suggests important roles of mKirre in later developmental processes, especially the synapse formation."
< "Q8BR86-1","RefSeq","NP_001177840.1","12665856","Involved in the hematopoietic supportive capacity of OP9 mouse stromal cells"
---
> "Q91ZF2-1","RefSeq","NP_062412.1","23541586","Disruption of IRE1alpha and XBP1 drastically attenuated the expression of Cts7 and Cts8, which are essential cathepsins for placenta formation."
9178a12234,12241
> "Q3U0M1-1","RefSeq","NP_850993.2","24011459","NIBP is extensively expressed in the enteric nervous system with relatively high level in a subpopulation of enteric neurons."
> "Q3U0M1-1","RefSeq","NP_850993.2","20004763","TRAPPC9 has a role in brain development, possibly through its effect on NF-kappaB activation and protein trafficking in the postmitotic neurons of the cerebral cortex"
> "Q3U0M1-1","RefSeq","NP_850993.2","19656848","Data show Trs130 (mTrs130) is a component of an analogous TRAPP complex that this complex is enriched on COPI (Coat Protein I)-coated vesicles it specifically activates Rab1."
> "Q3U0M1-1","RefSeq","NP_850993.2","16470246","IBP, a novel regulator of Rho GTPases, is required for optimal T cell effector function, lymphocyte homeostasis, and the prevention of systemic autoimmunity."
> "Q3U0M1-1","RefSeq","NP_850993.2","15951441","NIBP is a NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation."
> "Q60695-1","RefSeq","NP_058542.2","24887395","Rgl1 expression was strongly reduced by COX-2 deletion across all examined tissues. Publication Status: Online-Only"
> "P63101-1","RefSeq","NP_035870.1","30096435","It has been proposed that MsrA-dependent 14-3-3 zeta ubiquitination affects the regulation of alpha synuclein degradation and dopamine synthesis in the brain."
> "P63101-1","RefSeq","NP_035870.1","29101850","These results demonstrate that miR-146a enhances class switch and secretion of IgE in B cells by upregulating 14-3-3sigma expression, and suggest that miR-146a may be a potential target for asthma therapy."
9180a12244
> "Q8BP47-1","RefSeq","NP_081626.2","19631775","NARS is one of the important mediators of FGF2 induced survival signaling in osteoblasts through the activation of PI3K/Akt survival pathway."
9195a12260,12262
> "Q8R0Z2-1","RefSeq","NP_666063.1","21625959","This result suggests that hnRNP F directs formation of the exon 4 minus variant of ENOX2"
> "Q8R0Z2-1","RefSeq","NP_666063.1","18980249","The tissue expression of tNOX mRNA was greatest in heart, lung and liver. When these tissues were analyzed for cell size."
> "Q8R0Z2-1","RefSeq","NP_666063.1","17115410","Data show that growth of transgenic mouse embryonic fibroblasts overexpressing tNOX is inhibited by low concentrations of the anticarcinogenic tNOX inhibitors epigallocatechin-3-gallate and phenoxodiol."
9198a12266
> "Q8BYW1-1","RefSeq","NP_780685.2","27566826","Using Arhgap25-deficient mice, it identified ARHGAP25 as a relevant negative regulator of leukocyte transendothelial migration."
9214a12283,12284
> "O88829-1","RefSeq","NP_035505.2","30576498","HEK-293T clones permanently expressing HaloTag-ST3GAL5 carrying each of the five variants were assessed by quantitative PCR, flow cytometry, western blotting and confocal microscopy. Compared with the very mild phenotype of st3gal5 KO mouse models, the results suggest that unknown mechanisms, in addition to the lack of a-b-c-series gangliosides, contribute to the syndrome."
> "O88829-1","RefSeq","NP_035505.2","28808804","A new liver-specific c-type mRNA transcriptional variant of mouse ST3GAL5 protein has been identified."
9221a12292
> "Q9R0N6-1","RefSeq","NP_061272.2","11751263","Syt VIII is a candidate for the Ca(2+) sensor that regulates acrosomal exocytosis in mammalian sperm"
9227a12299,12300
> "Q7TSY6-1","RefSeq","NP_573458.2","15988035","CELF protein activity is required for normal alternative splicing in the heart in vivo and normal CELF-mediated alternative splicing regulation is in turn required for normal cardiac function."
> "Q7TSY6-1","RefSeq","NP_573458.2","12438720","Cloning and characterization"
9245,9246d12317
< "Q9JJJ7-1","RefSeq","NP_076127.1","29066530","Porcn mosaicism results in reduced fertility."
< "Q9JJJ7-1","RefSeq","NP_076127.1","29036275","This study showed that postnatal ablation of Porcupine in the uterine luminal epithelium alone results in the decrease in endometrial gland number; mutant females are completely infertile."
9251a12323
> "Q8BVU0-1","RefSeq","NP_001297603.1","17971504","Lrch3 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
9260a12333,12336
> "Q1A3B0-1","RefSeq","NP_001157673.1","26887952","These results suggest that the phosphorylation of ceramide synthases may be a key regulatory point in the control of the distribution and levels of sphingolipids of various acyl-chain lengths."
> "Q1A3B0-1","RefSeq","NP_001157673.1","26045466","Testis-specific SLs, which we also link to CerS3 in human testis, are quintessential for male fertility."
> "Q1A3B0-1","RefSeq","NP_001157673.1","18308723","Both glycans and the particular acyl chains of germinal sphingolipids are relevant for proper completion of meiosis"
> "Q1A3B0-1","RefSeq","NP_001157673.1","16753040","The isolation and characterization of LASS3 and LASS3-long are reported."
9264a12341,12343
> "Q99P21-1","RefSeq","NP_573513.2","30698731","These findings suggest that MUTYH does not rely upon the wedge residue for damage site recognition, but this residue stabilizes the lesion recognition complex."
> "Q99P21-1","RefSeq","NP_573513.2","28059467","Results suggested that MYH, which interacts with TRADD, inhibits TNF-alpha necroptotic signaling. Therefore, MYH inactivation is essential for necroptosis via the downregulation of caspase-8."
> "Q99P21-1","RefSeq","NP_573513.2","11864576","Replication-associated repair of adenine:8-oxoguanine mispairs by MYH"
9268,9270d12346
< "Q08943-1","RefSeq","NP_001129553.1","30344095","It has been demonstrated that FACT potentiates H2A.X-dependent signaling of DNA damage."
< "Q08943-1","RefSeq","NP_001129553.1","29953487","Uncovering the fine print of the CreERT2-LoxP system while generating a conditional knockout mouse model of Ssrp1 gene. Publication Status: Online-Only"
< "Q08943-1","RefSeq","NP_001129553.1","26842758","FACT is required for TOP1 binding to H3K4me3 at non-B DNA containing chromatin for the site-specific cleavage. Publication Status: Online-Only"
9271a12348,12352
> "Q62406-1","RefSeq","NP_032389.2","30391544","Pharmacological inhibition or siRNA mediated knockdown of IRAK1/4 attenuated Nod1-mediated activation of NF-kappaB, JNK, and the expression of proinflammatory cytokines. These results reveal that Nod1-mediated lipolysis promoted accumulation of DAG, which engaged PKCdelta and IRAK1/4 to augment inflammation in 3T3-L1 adipocytes."
> "Q62406-1","RefSeq","NP_032389.2","30361091","IRAK1 is one of the critical components involved in podocyte apoptosis in Diabetic nephropathy."
> "Q62406-1","RefSeq","NP_032389.2","30078230","Findings demonstrate that the pro- and anti-inflammatory responses to gAd in innate immune cells are time-dependent, and mediated by the activation of the IkappaB/NF-kappaB pathway, and IRAK-1 downregulation, respectively."
> "Q62406-1","RefSeq","NP_032389.2","29995830","Suppression of inflammatory responses and T cells apoptosis were observed with elevated expression of IRAK-M and PDL-1, and interference and neutralization of these 2 molecules led to partly reversed suppression of inflammation. Publication Status: Online-Only"
> "Q62406-1","RefSeq","NP_032389.2","29804558","The expression of IL-1 receptor-associated kinase 1 (IRAK1) that regulates NF-kappaB, p38, and the JNK signaling pathways, was also increased by MPQP."
9280a12362
> "Q9DCM0-1","RefSeq","NP_075643.1","23800285","Ethe1 deficiency disrupts post translational amino acid modification and mitochondrial metabolic systems. Publication Status: Online-Only"
9281a12364,12367
> "Q9ESG4-1","RefSeq","NP_065651.1","28159899","This study shows that Tmem27-mediated cross-presentation supports intrahepatic adaptive antiviral immune responses and may lead to insights into the nature of how the liver acts as a primary site of CD8+ T cell activation Erratum:[J Immunol. 2018 Oct 15;201(8):2521. PMID: 30217828]"
> "Q9ESG4-1","RefSeq","NP_065651.1","26240152","Analysis of the interaction of amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin"
> "Q9ESG4-1","RefSeq","NP_065651.1","24048198","Collectrin is a consequential link between the transport of l-arginine and endothelial nitric oxide synthase uncoupling in hypertension."
> "Q9ESG4-1","RefSeq","NP_065651.1","16330324","Tmem27 is a pancreatic beta cell transmembrane protein that regulates cell growth of pancreatic islets"
9286a12373,12376
> "Q8BRE0-1","RefSeq","NP_076216.3","27471269","The main RetGC-binding interface on RD3 required for the negative regulation of the cyclase localizes to the Lys(87)-Leu(122) region."
> "Q8BRE0-1","RefSeq","NP_076216.3","27150101","Study describes a mouse model of Leber's Congenital Amaurosis type 1 and 12 with autosomal recessive mutation in rd3 gene. The substitution mutation in the Rd3 gene is predicted to cause a stop codon after residue 106."
> "Q8BRE0-1","RefSeq","NP_076216.3","25477517","Direct association between RD3 and GCAP1 is important for GC1 targeting."
> "Q8BRE0-1","RefSeq","NP_076216.3","23740938","Studies indicate that RD3 plays an essential role in the exit of guanylate cyclase from the endoplasmic reticulum and its trafficking to photoreceptor outer segments."
9291,9292c12381,12391
< "Q8JZL7-1","RefSeq","NP_665838.1","28947785","The authors show that knockdown of the lipopolysaccharide (LPS)-induced cytoplasmic circular RNA, mcircRasGEF1B, results in altered expression of a wide array of genes. Pathway analysis revealed an overall enrichment of genes involved in cell cycle progression, mitotic division, active metabolism, and of particular interest, NF-kappaB, LPS signaling pathways, and macrophage activation. Publication Status: Online-Only"
< "Q8JZL7-1","RefSeq","NP_665838.1","20090772","Upon toll-like receptor activation, RasGEF1b may trigger Ras-like proteins and regulate specific biological activities of macrophages."
---
> "Q9D6V8-1","RefSeq","NP_080696.1","23622065","This study demonstrated that activity-dependent degradation of PAIP2A relieves translational inhibition of memory-related genes through PABP reactivation and conclude that PAIP2A is a pivotal translational regulator of synaptic plasticity and memory."
> "Q9D6V8-1","RefSeq","NP_080696.1","22190698","PABP interacting protein 2A (PAIP2A) regulates specific key proteins during spermiogenesis in the mouse. Publication Status: Online-Only"
> "Q9D6V8-1","RefSeq","NP_080696.1","21957478","Paip2 is able to function as a tumor suppressor"
> "Q9D6V8-1","RefSeq","NP_080696.1","15175342","PAIP2 is a crucial regulator of VEGF mRNA and has a role in regulating angiogenesis"
> "Q6Y685-1","RefSeq","NP_955355.1","27338930","We show that T cells deficient for acetyl-CoA carboxylase 1 (TACC1) are dramatically less pathogenic than wild-type (WT) T cells in a lethal C57BL/6 into BALB/c model of acute GVHD and permitted sustained survival of recipient mice."
> "Q8K3I4-1","RefSeq","NP_653140.1","28673385","Here, the authors show that exophilin-8 accumulates granules in the cortical F-actin network not by direct interaction with myosin-Va, but by indirect interaction with a specific form of myosin-VIIa through its previously unknown binding partner, RIM-BP2. Publication Status: Online-Only"
> "Q8K3I4-1","RefSeq","NP_653140.1","21441305","Exophilin8 transiently clusters insulin granules at the actin-rich cell cortex prior to exocytosis"
> "Q8K3I4-1","RefSeq","NP_653140.1","19317802","Myrip is a versatile Rab27a-associated myosin-activating protein that mediates cellular activation of MyoVa and MyoVIIa via non-overlapping domains."
> "Q8K3I4-1","RefSeq","NP_653140.1","17827149","Indicate that MyRIP functions as a scaffolding protein that links protein kinase A to components of the exocytosis machinery"
> "Q8K3I4-1","RefSeq","NP_653140.1","15927964","Slac2-c acts as a functional myosin VIIa receptor and the Rab27A.Slac2-c x myosin VIIa tripartite protein complex regulates the transport of retinal melanosomes in pigment epithelium cells"
> "Q8K3I4-1","RefSeq","NP_653140.1","12221080","Synaptotagmin-like protein homologue lacking C2 domains-c) is a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin GeneRIF: Slac2-c/MyRIP contains an N-terminal Slp homology domain (SHD) and functions as a linker protein that interacts with myosin Rab27A/B, VIIa/Va, and actin."
9296,9297d12394
< "Q6PKN7-1","RefSeq","NP_001239411.1","25525809","Results showed that absence of Inca1 mildly affects normal hematopoiesis under homeostatic conditions but controls hematopoiesis after induction of cytotoxic stress and plays a role in the maintenance of leukemia development in acute myeloid leukemia. Publication Status: Online-Only"
< "Q6PKN7-1","RefSeq","NP_001239411.1","21540187","Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling"
9300a12398,12401
> "P09242-1","RefSeq","NP_031457.2","30251694","Study results from cerulein induced pancreatitis model in TNAP+/- mice show that altered TNAP expression results in heightened pancreatic inflammation, which may be explained by an augmented response of neutrophils and by a higher sensitivity of acinar cells to cerulein injury."
> "P09242-1","RefSeq","NP_031457.2","21191615","Data show that alkaline phosphatase (AP) activity in brain vessels and parenchyma in which AP exhibits specific patterns is attributable to TNAP."
> "P09242-1","RefSeq","NP_031457.2","19874193","Tissue-nonspecific alkaline phosphatase is the enzyme that hydrolyzes both ATP and inorganic pyrophosate in matrix vesicles."
> "P09242-1","RefSeq","NP_031457.2","17539739","Alkaline phosphatase 2(Hpp/Hpp) mice develop late-onset skeletal disease, notably defective endochondral ossification and bone mineralization that leads to arthropathies of knees and shoulders"
9303a12405,12408
> "Q61645-1","RefSeq","NP_068677.2","29422543","These findings suggest that Hr mRNA expression is regulated at the post-transcriptional level via IRES-mediated translation control through interaction with PCPB2, but not in MUHH. Publication Status: Online-Only"
> "Q61210-1","RefSeq","NP_032514.1","29130930","Data highlight the importance of Arhgef1 in cardiovascular disease and suggest targeting Arhgef1 as a potential therapeutic strategy against atherosclerosis."
> "Q61210-1","RefSeq","NP_032514.1","27923664","Arhgef1 controls the process of neurite formation in newborn cortical neurons derived from neural progenitor cells"
> "Q61210-1","RefSeq","NP_032514.1","27489999","These findings reveal that Arhgef1 functions as a negative regulator of neurite outgrowth through regulating RhoA-cofilin pathway and actin dynamics."
9304a12410,12414
> "Q9JHG6-1","RefSeq","NP_062339.2","30389725","Regulator of Calcineurin 1 (RCAN1), a feedback inhibitor of the calcium-activated protein phosphatase calcineurin (CN), acts to suppress two distinctly different mechanisms of non-shivering thermogenesis."
> "Q9JHG6-1","RefSeq","NP_062339.2","30366682","Study found that RCAN1 RNA expression was suppressed in glomeruli in human diabetic nephropathy, IgA nephropathy, and lupus nephritis, and in mouse models of HIV-associated nephropathy and diabetic nephropathy. Findings suggest that epigenetic suppression of RCAN1 aggravates podocyte injury in the setting of HIV infection and diabetic nephropathy."
> "Q9JHG6-1","RefSeq","NP_062339.2","30442942","Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture. Publication Status: Online-Only"
> "Q9JHG6-1","RefSeq","NP_062339.2","30139658","This study demonstrated that Rcan1 is regulated by oxidative stress and identified RCAN1 as a potential diagnostic marker of acute pancreatitis."
> "Q9JHG6-1","RefSeq","NP_062339.2","29799862","These findings demonstrate a novel regulatory role of RCAN1 in TLR signaling, which differentially regulates MyD88 and TRIF pathways. Publication Status: Online-Only"
9306a12417,12421
> "Q99MY8-1","RefSeq","NP_619620.3","30487570","The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression Publication Status: Online-Only"
> "Q99MY8-1","RefSeq","NP_619620.3","29724719","Study shows that mutations associated with acute myelogenous leukemia (AML) result both in loss of miR-142-3p function and in decreased miR-142-5p expression. During hematopoietic maturation, loss of Mir142 increased ASH1L protein expression and consequently resulted in the aberrant maintenance of Hoxa gene expression in myeloid-committed hematopoietic progenitors."
> "Q99MY8-1","RefSeq","NP_619620.3","28598443","Ash1l upregulates Smad3 expression by directly targeting Smad3 promoter to increase local H3K4 trimethylation. Publication Status: Online-Only"
> "Q99MY8-1","RefSeq","NP_619620.3","28374742","Loss of Ash1l leads to more proliferative keratinocytes in disturbed differentiation stages and Ash1l mutation leads to delayed re-epithlialization but increased keratinocyte proliferation at the wound edge. Publication Status: Online-Only"
> "Q99MY8-1","RefSeq","NP_619620.3","17544230","ASH1 mono- or di-methylates histone H3 K36 but not any other lysine residues of recombinant unmodified mammalian histones"
9310a12426
> "Q31125-1","RefSeq","NP_032228.2","27736879","These findings provide evidence for the importance of ZIP7 in maintenance of intestinal epithelial homeostasis through the regulation of ER function in proliferative progenitor cells and maintenance of intestinal stem cells. Therapeutic targeting of ZIP7 could lead to effective treatment of gastrointestinal disorders. Publication Status: Online-Only"
9320a12437,12438
> "Q3USZ2-1","RefSeq","NP_001028965.1","26092847","These findings indicate that CHD1 plays important roles in mouse early embryogenesis via activation of Hmgpi at zygotic gene activation."
> "Q3USZ2-1","RefSeq","NP_001028965.1","19915186","Reduction of Hmgpi transcript levels caused developmental loss of preimplantation embryos and implantation failures."
9323a12442,12445
> "Q9JJY3-1","RefSeq","NP_067466.1","30866785","Results suggest that ZIKV modulates SMPD3 activity in cortical neurons for its infection and transmission through exosomes perhaps leading to severe neuronal death that may result in neurological manifestations such as microcephaly in the developing embryonic brains."
> "Q9JJY3-1","RefSeq","NP_067466.1","29141446","Hypoxic culture augments miR-210 and nSMase2 activities in MSCs and their secreted exosomes, and this is responsible at least in part for the enhanced cardioprotective actions of exosomes derived from hypoxia-treated cells."
> "Q9JJY3-1","RefSeq","NP_067466.1","28961856","The authors report here that host delivery of Cryptosporidium parvum Cdg7_FLc_1000 RNA results in inhibition of epithelial cell migration through suppression of the gene encoding sphingomyelinase 3 (SMPD3)."
> "Q9JJY3-1","RefSeq","NP_067466.1","28889482","The enzymes involved in sphingolipid metabolism are expressed abnormally in B cells from lupus-prone mice. TLR signaling induced the abnormal expression of sphingomyelin phosphodiesterase 3 (SMPD3). TLR signaling also induced the transport of SMPD3 from the Golgi apparatus. Furthermore, the dysfunction of SMPD3 enhanced TLR-induced inflammatory response of B cells and macrophages in turn."
9331,9339d12452
< "Q9ET54-1","RefSeq","NP_001280701.1","29720549","Taken together, this study demonstrates that palladin plays an important role in themorphology and dynamic behavior of podocytes in vivo and in vitro."
< "Q9ET54-1","RefSeq","NP_001280701.1","29712777","Palladin operates downstream of mTOR to modulate axon morphogenesis"
< "Q9ET54-1","RefSeq","NP_001280701.1","28739877","These results show a new function for PALLD as a crucial regulator of the early phase of phagocytosis by elaborating dynamic actin polymerization and depolymerization"
< "Q9ET54-1","RefSeq","NP_001280701.1","28340616","Study shows palladin is expressed with proper spatio-temporal pattern in the neural folds. It plays a crucial role in regulating mouse cranial neural tube closure by modulating cytoskeleton, proliferation, differentiation, apoptosis, and adhesion of neural epithelium Publication Status: Online-Only"
< "Q9ET54-1","RefSeq","NP_001280701.1","27865965","The aggregation of palladin(+/-) platelets was increased in response to low levels of thrombin, U46619, and collagen. This study also reports enhanced spreading of palladin(+/-) platelets on immobilized fibrinogen (Fg) and increased rate of clot retraction in platelet-rich plasma (PRP) containing palladin(+/-) platelets."
< "Q9ET54-1","RefSeq","NP_001280701.1","14983521","The actin-associated protein palladin may play an important role in recruiting VASP to sites of actin filament growth, anchorage, and crosslinking."
< "Q925J9-1","RefSeq","NP_001073587.1","29293266","B-cell conditional deficient mice for the Med1 subunit display robust somatic hypermutation."
< "Q925J9-1","RefSeq","NP_001073587.1","29187405","High MED1 expression is associated with metastasis in breast Cancer."
< "Q925J9-1","RefSeq","NP_001073587.1","28673966","Data, including data from studies using cells from transgenic/knockout mice, suggest that Med1 plays role in enamel formation; Med1 induces Alpl via stimulation of Notch1 signaling by forming Notch1-RBP-Jk complex on Alpl promoter. (Med1 = mediator complex subunit 1; Alpl = alkaline phosphatase, liver-bone-kidney; Notch1 = Notch gene homolog 1; RBP-Jk = kappa J region recombining binding protein suppressor of hairless)"
9346a12460,12464
> "P68500-1","RefSeq","NP_001164258.1","29264679","These findings link Cntn5 deficiency to obesity and hypertension"
> "P68500-1","RefSeq","NP_001164258.1","28346043","Demonstrate a selective role of Cntn5 in development of the cerebral cortex without overt behavioral phenotypes"
> "P68500-1","RefSeq","NP_001164258.1","27539848","Protein-tyrosine phosphatase receptor type G (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system"
> "P68500-1","RefSeq","NP_001164258.1","22285261","Findings demonstrated that NB-2 interacts with APLP and that both NB-2 and APLP1 are localized at presynaptic sites, suggesting that NB-2 associates with APLP1 in a cis manner on the presynaptic membrane"
> "P68500-1","RefSeq","NP_001164258.1","19818338","NB-2 deficiency causes a deficit in synapse formation and then induces apoptosis in MNTB and VCN neurons, affecting auditory brainstem function"
9347a12466
> "Q9DCW2-1","RefSeq","NP_032906.2","12509439","PLSCR2 is expressed predominantly in the cell nucleus"
9351a12471,12479
> "O89106-1","RefSeq","NP_034340.1","27513973","Fhit loss and subsequent thymidine kinase 1 inactivation, combined with selective pressures, leads to neoplasia-associated alterations in genes and gene expression patterns in vitro and in vivo"
> "O89106-1","RefSeq","NP_034340.1","26782170","Fhit-deficiency mutation signature also resembles a C>T and T>C mutation signature reported for human papillary kidney cancers and a similar signature recently reported for esophageal and bladder cancers, cancers that are frequently Fhit deficient."
> "O89106-1","RefSeq","NP_034340.1","24244712","Fhit deficiency-induced global genome instability promotes mutation and clonal expansion Publication Status: Online-Only"
> "O89106-1","RefSeq","NP_034340.1","24223161","Fhit delocalizes annexin A4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel. Publication Status: Online-Only"
> "Q8R5H6-1","RefSeq","NP_114083.1","30352064","WAVE-1 restoration improves maze exploration performance of GluN1 knockdown mice Publication Status: Online-Only"
> "Q8R5H6-1","RefSeq","NP_114083.1","29911975","Data indicate a molecular protocadherin alpha (Pcdhalpha)/Wiskott-Aldrich syndrome potein Family (WAVE)/proline-rich tyrosine kinase 2 (Pyk2)/Rac1 axis from protocadherin cell-surface receptors to actin cytoskeletal dynamics in cortical neuron migration and dendrite morphogenesis in mouse brain. Publication Status: Online-Only"
> "Q8R5H6-1","RefSeq","NP_114083.1","28115704","Wiskott-Aldrich syndrome protein family (WAVE1) knocked out (KO) in neurons expressing the D1 dopamine receptor (D1-KO) exhibited a significant decrease in place preference associated with cocaine."
> "Q8R5H6-1","RefSeq","NP_114083.1","12578964","Role in causing sensorimotor retardation and reduced learning and memory in mice"
> "Q9JMF7-1","RefSeq","NP_065062.1","12198133","Results support a role for dolichyl pyrophosphate (Dol-P-P) phosphatase (Dolpp1) in the recycling of Dol-P-P discharged during protein N-glycosylation reactions on the luminal leaflet of the endoplasmic reticulum in mammalian cells [Dolpp1]."
9354a12483,12486
> "Q9D7V9-1","RefSeq","NP_080248.2","28065729","Both inhibitors reduced several markers of macrophage activation, such as mRNA expression of inflammatory mediators, as well as cytokine and prostaglandin production, with however some differences between FAAH and NAAA inhibition. Our results support an important role for inhibition of NAE hydrolysis and NAAA inhibition in particular in controlling macrophage activation, and thus inflammation."
> "Q9D7V9-1","RefSeq","NP_080248.2","25384424","NAAA inhibition increases palmitoylethanolamide levels in the colon and reduces colon inflammation and systemic inflammation"
> "Q9D7V9-1","RefSeq","NP_080248.2","23218523","NAAA regulates peripheral pain initiation by interrupting endogenous fatty acid ethanolamide signaling at PPAR-alpha."
> "Q9D7V9-1","RefSeq","NP_080248.2","16154384","Results suggest that N-acylethanolamine-hydrolyzing acid amidase and fatty acid amide hydrolase cooperatively degrade anandamide and other N-acylethanolamines in macrophages."
9365a12498
> "Q9Z210-1","RefSeq","NP_035199.3","21954064","The alterations in the brain caused by the deletion of a single allele of the Pex11beta gene, are reported."
9370a12504,12505
> "B8ZXI1-1","RefSeq","NP_083404.2","29862811","In the crystal, QTRT2 is clearly present as a homodimer that is strikingly similar to that formed by bacterial TGT. In particular, a cluster of four aromatic residues within the interface of the bacterial TGT, which constitutes a 'hot spot' for dimer stability, is present in a similar constellation in QTRT2."
> "B8ZXI1-1","RefSeq","NP_083404.2","19414587","TGT weakly interacts with the outer mitochondrial membrane possibly through association with Qv1(QTRD1 variant 1), which was found to be stably associated with the organelle"
9380,9381c12515,12516
< "Q8K2P6-1","RefSeq","NP_001124540.1","21238580","Findings together provide novel evidence that mitochondria are the direct hypoxic targets in PASMCs, in which Rieske iron-sulfur protein in complex III may serve as an essential, primary molecule that mediates the hypoxic ROS generation"
< "Q8K2P6-1","RefSeq","NP_001124540.1","18703841","Mouse Rieske-type ferredoxin was shown to be capable of accepting electrons from both eukaryotic and prokaryotic oxidoreductases, although it was unable to serve as an electron donor for a bacterial monooxygenase complex."
---
> "Q9Z0H4-1","RefSeq","NP_034290.2","23468433","CELF1 and CELF2 may underlie conserved, developmentally regulated, tissue-specific processes in vertebrate embryos"
> "Q9Z0H4-1","RefSeq","NP_034290.2","12022233","NAPOR may be one of a group of closely related proteins involved in splicing regulation within the brain."
9397,9398c12532,12533
< "Q9ET38-1","RefSeq","NP_001033679.1","25678664","This study presents the structure of mammalian claudin-19 in complex with C-CPE at 3.7 A resolution."
< "Q9ET38-1","RefSeq","NP_001033679.1","15589828","Sp1 site is crucial for Cldn19 gene expression in kidney cells."
---
> "Q9QY40-1","RefSeq","NP_062533.2","15218527","Plexin-B3 is a functional receptor for semaphorin 5A"
> "Q9CQ79-1","RefSeq","NP_742051.1","28626760","Results demonstrated that Txndc9 is crucial for mouse oocyte maturation by regulating spindle assembly, polar body extrusion, and redox status."
9403,9405d12537
< "Q9Z0P7-1","RefSeq","NP_001020562.1","30554998","Establishes the dual role of SUFU inSonic Hedgehog medulloblastoma (MB) and provides mechanistic insights into transcriptional regulation underlying Gli2-mediated SHH MB tumorigenesis"
< "Q9Z0P7-1","RefSeq","NP_001020562.1","29923621","Study found that miR-423 targets the 3'-untranslated region (UTR) of Sufu, and the expression of Sufu can be inhibited by the overexpression of miR-423, indicating that Sufu could be the target of miR-423."
< "Q9Z0P7-1","RefSeq","NP_001020562.1","29515120","Beta-Arrestin2 increases the Itch-mediated ubiquitylation of SuFu. Publication Status: Online-Only"
9411c12543,12544
< "Q6PA06-1","RefSeq","NP_062691.3","27669642","Endoplasmic reticulum morphology is markedly disrupted in ATL1, ATL2, and ATL3 knockout cells."
---
> "Q60612-1","RefSeq","NP_001278857.1","30365112","Abeta and tau may be considered as novel biomarkers of sleep disorder in AD pathology, and that they function by regulating the expression levels of orexin A and adenosine A1R."
> "Q60612-1","RefSeq","NP_001278857.1","30315630","Adenosine A1 receptor-mediated signaling broadly extends to all subdivisions of the auditory cortex and medial geniculate neurons."
9432a12566,12569
> "B2RUR8-1","RefSeq","NP_001020785.1","28880268","Cezanne may be a novel antioncogene that has a pivotal role in the invasion of hepatocellular carcinoma. Publication Status: Online-Only"
> "B2RUR8-1","RefSeq","NP_001020785.1","28489822","TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling"
> "B2RUR8-1","RefSeq","NP_001020785.1","26903241","These findings establish Otud7b as a positive regulator of T cell receptor-proximal signaling and T cell activation, highlighting the importance of deubiquitination in regulating Zap70 function."
> "B2RUR8-1","RefSeq","NP_001020785.1","21097510","DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB."
9437a12575,12584
> "Q91Z40-1","RefSeq","NP_663520.2","21551061","Findings show that at least 4 IFN-gamma-inducible Gbps--Gbp1, Gbp6, Gbp7, and Gbp10--conferred cell-autonomous immunity to listerial or mycobacterial infection within macrophages and gene-deficient animals"
> "P63158-1","RefSeq","NP_034569.1","30763674","Results indicate that Partial Sciatic Nerve Ligation-induced anxiodepressive-like behavior is likely mediated by HMGB1."
> "P63158-1","RefSeq","NP_034569.1","31040263","HMGB1 reduced the expression of tight junctions between endothelial cells, including VE-cadherin and ZO-1, and increased endothelial permeability, and both were blocked by propofol. We found that MLVECs exhibited mitochondrial oxidative damage by HMGB1. Publication Status: Online-Only"
> "P63158-1","RefSeq","NP_034569.1","30581279","Epac1 deacetylates HMGB1 through increased IGFBP-3 and SIRT1 levels in the retinal vasculature. Publication Status: Online-Only"
> "P63158-1","RefSeq","NP_034569.1","30595050","Results indicate that HMGB1 may be an important contributor in the prevention and treatment of pneumonia of carbapenem-resistant-induced pneumonia"
> "Q6P1H6-1","RefSeq","NP_082198.1","25343476","Restoring the expression of one Zfp335 target, Ankle2, partially rescues T cell maturation. Publication Status: Online-Only"
> "Q99JY9-1","RefSeq","NP_076224.1","27927957","We find that the expression of the actin polymerization complex Arp2/3 is reduced in dysbindin-deficient cells, thus affecting actin-dependent phenotypes"
> "Q99JY9-1","RefSeq","NP_076224.1","27181356","Arp2 and Arp3 expression was increased under atherosclerotic conditions both in ApoE-/- mice and in oxidized low-density lipoproteins stimulated human coronary artery endothelial cells (HCAECs)."
> "Q99JY9-1","RefSeq","NP_076224.1","26975831","Possess a mechanism to pass through micrometric constrictions. This mechanism is based on a rapid Arp2/3-dependent actin nucleation around the nucleus that disrupts the nuclear lamina, the main structure limiting nuclear deformability. Publication Status: Online-Only"
> "Q99JY9-1","RefSeq","NP_076224.1","12589062","Scar2 and the Arp2/3 complex appear to be involved in the establishment and maintenance of Golgi polarity during directed migration"
9446,9449c12593,12595
< "Q3U9N9-1","RefSeq","NP_001107804.1","29535325","We report hearing loss in mice with mutations in Slc16a2 and a related gene Slc16a10 (Mct10, Tat1). Deficiency of both transporters results in retarded development of the sensory epithelium similar to impairment caused by hypothyroidism, compounded with a progressive degeneration of cochlear hair cells and loss of endocochlear potential. Publication Status: Online-Only"
< "Q3U9N9-1","RefSeq","NP_001107804.1","24248460","Mct10 participates in tissue-specific TH transport and also contributes to the generation of the unusual serum TH profile characteristic for Mct8 deficiency"
< "Q3U9N9-1","RefSeq","NP_001107804.1","17273864","The aromatic amino acid diffusion pathway TAT1 can control neutral amino acid efflux via neighboring exchanger LAT2-4F2hc, by recycling its aromatic influx substrates"
< "Q3U9N9-1","RefSeq","NP_001107804.1","16245314","TAT1 is a basolateral epithelial transporter and can function as a net efflux pathway for aromatic amino acids. We propose that it may supply parallel exchangers with recycling uptake substrates that could drive the efflux of other amino acids."
---
> "Q9D517-1","RefSeq","NP_443747.2","29284664","It identified lysophosphatidic acid acyltransferase (LPAAT)3 as an enzyme that was upregulated in myoblasts during in vitro differentiation and selectively incorporated DHA intophosphatidylcholine and phosphatidylethanolamine."
> "Q9D517-1","RefSeq","NP_443747.2","28578316","Data suggest that PL-DHA (docosahexaenoic acid-containing phospholipids) contribute to visual function by maintaining disc shape in photoreceptor cells; PL-DHA disappears from outer segment in LPAAT3-knockout mice; LPAAT3-knockout mice exhibit abnormalities in retinal layers, disordered disc morphology in photoreceptor cells, and impaired visual function."
> "Q9D517-1","RefSeq","NP_443747.2","28578315","Data suggest that LPAAT3 is required for producing docosahexaenoic acid- (DHA)-containing phospholipids in various tissues, such as the testes and retina; LPAAT3-knockout mice exhibit severe male infertility with abnormal sperm morphology; lack of LPAAT3 causes drastic reduction of DHA-containing phospholipids in spermatids with excess cytoplasm around the sperm head."
9451a12598,12606
> "Q8R4T1-1","RefSeq","NP_619627.3","26295839","Kif12 is a candidate gene within the major polycystic kidney disease modifier 2 locus that modulates renal cystic disease severity in the Cys1cpk mouse. Publication Status: Online-Only"
> "Q8CG19-1","RefSeq","NP_996841.1","27956181","LTBP1 has a role in female reproduction"
> "Q8CG19-1","RefSeq","NP_996841.1","25805620","Data show the complete knockout of both isoforms of LTBP-1 leads to defective cardiovascular development and subsequent perinatal lethality supporting the idea that LTBP-1 is essential in the development of the great arteries and cardiac cushions."
> "O54826-1","RefSeq","NP_034934.2","30102091","In lung metastasis sites, the knockdown of MLLT10 in SW620 cells significantly inhibited Vimentin expression, whereas the E-Cadherin was increased. These results indicate that MLLT10 regulates the metastasis of CRC cells via EMT."
> "O54826-1","RefSeq","NP_034934.2","28931923","Together these data are the first to demonstrate that Af10-dependent H3K79me is essential for development of nasal processes and adjacent tissues, and consequent midfacial formation. Publication Status: Online-Only"
> "O54826-1","RefSeq","NP_034934.2","25464900","Results provide evidence that transformation driven by MLL fusions as well as the recurrent AML-associated NUP98-NSD1 fusion oncogene is critically dependent on the ability of AF10 to stimulate DOT1L activity."
> "O54826-1","RefSeq","NP_034934.2","24397609","During leukemogenesis, CALM-AF10 plays critical roles in the cytoplasm."
> "O54826-1","RefSeq","NP_034934.2","21681188","Further suggest that future approaches to antagonize CALM-AF10-induced transformation should incorporate strategies, which aim at blocking these key domains"
> "O54826-1","RefSeq","NP_034934.2","21103407","Conclude that Mllt10/Af10-Dot1l are essential, largely dedicated activators of Wnt-dependent transcription, critical for maintenance of intestinal proliferation and homeostasis Erratum:[PLoS Biol. 2017 Feb 7;15(2):e1002596. PMID: 28170393] Publication Status: Online-Only"
9455a12611
> "P54846-1","RefSeq","NP_032762.1","30713422","In the Nphp5-/- and cone-only Nphp5-/-; Nrl-/- mice, cone outer segments did not form, but mutant cones continued to express cone pigments in the inner segments without obvious signs of cone cell death. Publication Status: Online-Only"
9457a12614,12620
> "Q9D6Y7-1","RefSeq","NP_080598.2","30096435","It has been proposed that MsrA-dependent 14-3-3 zeta ubiquitination affects the regulation of alpha synuclein degradation and dopamine synthesis in the brain."
> "Q9D6Y7-1","RefSeq","NP_080598.2","29649787","Our findings demonstrate that reversal of methionine oxidation is required for maintenance of cellular homeostasis in the absence of increased oxidative stress. These data provide the first link between autophagy and activation of Nrf2 in the setting of MsrA deletion"
> "Q9D6Y7-1","RefSeq","NP_080598.2","29929200","MsrA knockout mice showed an increased sensitivity to noise at young and older ages, suggesting that MsrA is part of a mechanism that protects the cochlea from acoustic damage. MsrA mRNA in the cochlea was increased following acoustic stimulation."
> "Q9D6Y7-1","RefSeq","NP_080598.2","28803836","MsrA protects against lipopolysaccharide-induced septic shock, and negatively regulates proinflammatory responses via inhibition of the ROS-MAPK-NF-kappaB signaling pathways."
> "Q9D6Y7-1","RefSeq","NP_080598.2","28442342","Collectively, our results suggest that MsrA protects hepatocytes from APAP-induced cytotoxicity through the modulation of TXNRD1 expression."
> "Q9D6Y7-1","RefSeq","NP_080598.2","15924425","Proper structure-function organization of MsrA plays a role in subcellular distribution of this protein in mouse cells."
> "Q9D6Y7-1","RefSeq","NP_080598.2","12792026","Msra expression is regulated by (dietary)selenium"
9463a12627
> "E9PW10-1","RefSeq","NP_001153884.1","25256710","Data indicate that TRIML2 is part of a feed-forward loop that activates p53 in cells expressing the R72 variant, particularly after prolonged stress."
9467d12630
< "O55176-3","RefSeq","NP_001076579.1","28067271","Praja1 promotes skeletal myogenesis through degradation of EZH2 upon p38alpha activation. Publication Status: Online-Only"
9481a12645,12649
> "Q91V45-1","RefSeq","NP_444474.1","30565563","We demonstrate that in the presence of E2, NKB signaling induces LH release in a kisspeptin-independent manner through the activation of NK3R (NKB receptor) neurons in the posterodorsal medial amygdala (MePD). Importantly, we show that chemogenetic activation of MePD Kiss1 neurons induces LH release, however, the stimulatory action of NKB in this area is Kiss1 neuron-independent. Publication Status: Online-Only"
> "Q91V45-1","RefSeq","NP_444474.1","29948931","These lines of evidence suggest that downregulation of Ob-R and kisspeptin/GPR54 in the murine hypothalamus may contribute to male hypogonadism caused by high-fat diet-induced obesity."
> "Q91V45-1","RefSeq","NP_444474.1","29931449","G-protein coupled receptor 54 (GPR54) deficiency leads to elevated experimental autoimmune encephalomyelitis (EAE) disease severity independent of the reproductive axis. GPR54 deficiency leads to impaired immunotolerance in association with reduced number of Regulatory T-Lymphocytes, increased T-cell activation, and altered thymocyte subsets."
> "Q91V45-1","RefSeq","NP_444474.1","14652023","The analysis of the GPR54 mutant mice revealed developmental abnormalities of both male and female genitalia and histopathological changes in tissues which normally contain sexually dimorphic features."
> "Q91V45-1","RefSeq","NP_444474.1","14573733","Mutations in GPR54 cause autosomal recessive idiopathic hypogonadotropic hypogonadism in humans and mice, suggesting that this receptor is essential for normal gonadotropin-releasing hormone physiology and for puberty."
9485,9489d12652
< "Q8BSP2-1","RefSeq","NP_001108604.1","27737961","Mice inheriting missense mutations in a condensin II subunit (Caph2(nes)) develop T-cell lymphoma"
< "Q8BSP2-1","RefSeq","NP_001108604.1","25961503","Condensin II (beta-kleisin) has an essential role during meiosis I in mouse oocytes and its function overlaps with that of condensin I (gamma-kleisin), which is otherwise redundant"
< "Q8BSP2-1","RefSeq","NP_001108604.1","25474630","Condensins I and II have overlapping and non-overlapping functions in Neural stem cells. Publication Status: Online-Only"
< "Q8BSP2-1","RefSeq","NP_001108604.1","22333158","We confirm that Ncaph2 can generate three different N-termini, all encoded by exon 1, one of which is translated from an alternative reading frame."
< "Q8BSP2-1","RefSeq","NP_001108604.1","17640884","Define a unique lineage-specific requirement for kleisin beta in mammalian T cell differentiation"
9505a12669,12672
> "P23204-1","RefSeq","NP_035274.2","31154022","Loss of PPARalpha from the intestine promotes colon carcinogenesis by increasing DNMT1/PRMT6-mediated DNA methylation."
> "P23204-1","RefSeq","NP_035274.2","30975991","Study in GPS2 knockout mice reveals that GPS2 in hepatocytes functionally cooperates with NCOR but not with SMRT to repress PPAR-alpha. These data collectively suggest that GPS2 promotes the progression of fatty liver disease as an epigenome modifier and PPAR-alpha-selective corepressor in hepatocytes. Publication Status: Online-Only"
> "P23204-1","RefSeq","NP_035274.2","30952952","Autophagy and mitochondrial metabolism are transcriptionally controlled by the class 3 PI3K which controls the nuclear receptor PPARalpha. Publication Status: Online-Only"
> "P23204-1","RefSeq","NP_035274.2","30866796","Data provide evidence that PPARalpha is a master regulator of intracellular lipid metabolism. Publication Status: Online-Only"
9511d12677
< "Q9JJT2-1","RefSeq","NP_001257930.1","16497798","GFRalpha4 signaling has a role in regulating calcitonin production in thyroid C cells of young mice"
9533,9534c12699,12703
< "Q80VW5-1","RefSeq","NP_001008791.1","28966015","C-terminal hairpin extensions of the whirlin PDZ domains mediate the transient supramodular assembly, which improves the binding capacity of the first domain towards its partners, such as Sans."
< "Q80VW5-1","RefSeq","NP_001008791.1","28387217","Gpsm2 defines an approximately 200 nm nanodomain at the tips of stereocilia and this localization requires the presence of Galphai3, myosin 15 and whirlin. Erratum:[Nat Commun. 2018 May 25;9:16188. PMID: 29799026] Publication Status: Online-Only"
---
> "Q2MH31-1","RefSeq","NP_082900.1","19213785","Chronological regulation of CBE1/Cbe1 expression during pulmonary differentiation suggests involvement in ciliogenesis, with an additional role during early lung development."
> "Q2MH31-1","RefSeq","NP_082900.1","18163442","SMRP1 was localized to the cytoplasm of step 9-12 elongated spermatids. The protein appeared in a cap formation that covered the caudal sides of the elongated nuclei."
> "Q2MH31-1","RefSeq","NP_082900.1","17971504","1110017D15Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
> "Q5SWY8-1","RefSeq","NP_001028399.1","23451068","Data show fructose-induced hepatic steatosis was exacerbated in the SGLT5-deficient mice"
> "Q62130-1","RefSeq","NP_033002.2","25690013","The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking. Publication Status: Online-Only"
9542a12712,12713
> "Q99PI4-1","RefSeq","NP_075021.1","28982975","Data suggest that phosphorylation does not affect catalytic activity of lipin 3 or its ability to associate with phosphatidic acid in vitro; different polybasic domains in lipin 1 and lipin 3 are responsible for phospho-regulation on the former but not the latter enzyme."
> "Q99PI4-1","RefSeq","NP_075021.1","17158099","Lipin-3 exhibits phosphatidate phosphatase type-1 (PAP1) activity, which has a key role in glycerolipid synthesis."
9548a12720
> "Q8BFR2-1","RefSeq","NP_848788.2","24588779","Restricted expression in the olfactory system suggests a possible role for Fstl5 in maintaining odor perception"
9558,9561c12730,12731
< "Q9Z1G4-1","RefSeq","NP_001229980.1","27512951","These results suggest that the Golgi complex may serve as a membrane platform for noncanonical autophagy where V-ATPase is a key player. Publication Status: Online-Only"
< "Q9Z1G4-1","RefSeq","NP_001229980.1","26427489","Data suggest a mechanism by which betaA3/A1-crystallin regulates lysosomal function by modulating the activity of V-ATPase."
< "Q9Z1G4-1","RefSeq","NP_001229980.1","24468901","Demonstrated that CRYBA1 coimmunoprecipitates with the ATP6V0A1/V0-ATPase a1 subunit"
< "Q9Z1G4-1","RefSeq","NP_001229980.1","24165939","V-ATPase membrane domain would allow the exocytotic machinery to discriminate fully loaded and acidified vesicles from vesicles undergoing neurotransmitter reloading."
---
> "Q9WUE3-1","RefSeq","NP_062694.1","19943161","Show (1) TSCytb's reduced spectra have a split a-band at already low ascorbate concentrations (at already high potential levels), and (2) it has two heme b redox centers, both with positive redox potentials, that differ by about 100 mV from each other"
> "Q9WUE3-1","RefSeq","NP_062694.1","17938141","101F6 exhibited ferric as well as azo-dye-reductase activity."
9567,9568c12737,12739
< "P97367-1","RefSeq","NP_001153040.1","30190278","A previously unknown link between PcG proteins and downregulation of RA-related signals to mediate the phase transition of Meis2 transcriptional status during forelimb patterning, is reported. Publication Status: Online-Only"
< "P97367-1","RefSeq","NP_001153040.1","29641989","Methylation impairs interaction with CRM1 without affecting PBX1 dimerization and thereby allows MEIS2 nuclear accumulation, a prerequisite for neuronal differentiation."
---
> "Q8BNX7-1","RefSeq","NP_796013.1","23029450","Nrac (gene A530016L24Rik) is localized to the plasma membrane, and highly induced during adipocyte differentiation."
> "Q7TPW1-1","RefSeq","NP_955759.2","26659360","These results further emphasize the role of NEXN in dilated cardiomyopathy and suggest a novel role in endomyocardial fibroelastosis."
> "Q7TPW1-1","RefSeq","NP_955759.2","24866383","NEXN as a novel gene for ASD and its function to inhibit GATA4 established a critical regulation of an F-actin binding protein on a transcription factor in cardiac development"
9572a12744,12745
> "Q3TL26-1","RefSeq","NP_032275.2","28702322","Loss of Tfb2m in pancreatic beta-cells results in progressive mitochondrial dysfunction and impaired insulin secretion in response to metabolic stimuli. Publication Status: Online-Only"
> "Q3TL26-1","RefSeq","NP_032275.2","12532263","Metazoans have two TFBM genes, suggesting that a duplication of the gene has permitted a more flexible regulation of mtDNA."
9575a12749
> "Q8BHM9-1","RefSeq","NP_848845.1","28338078","Study reveals a role of HAT-L4 in the epidermal barrier function to prevent body fluid loss, providing another example of cell membrane-bound serine proteases in epidermal development and function. Publication Status: Online-Only"
9580a12755,12757
> "Q62093-1","RefSeq","NP_035488.1","29903888","In a new conditional murine Srsf2(P95H) model, where the P95H mutation is expressed physiologically and heterozygously from its endogenous locus after Cre activation, the mutation must occur in the hemopoietic stem-cell-containing populations to promote myelomonocytic bias and expansion with transcriptional and RNA splicing changes.  With age, nontransplanted mutant animals develop progressive, transplantablable disease."
> "Q62093-1","RefSeq","NP_035488.1","29146882","Mutant Srsf2 leads to a compromised Hematopoietic stem cell function by causing abnormal RNA splicing and expression, contributing to the deregulated hematopoiesis that recapitulates the Myelodysplastic syndromes phenotypes, possibly as a result of additional genetic and/or environmental insults."
> "Q62093-1","RefSeq","NP_035488.1","28592444","Posttranslational modification of SR proteins underlies the regulation of their mRNA export activities and distinguishes pluripotent from differentiated cells."
9581a12759,12763
> "Q9EQH2-1","RefSeq","NP_109636.1","30365037","The ERAP1 behaves similar to acute-phase proteins, which are secreted into the blood in response to infectious/inflammatory stimuli and are involved in enhancing NO synthesis as a host defense mechanism."
> "Q9EQH2-1","RefSeq","NP_109636.1","30127455","ERAP1(-/-) mice may serve as a useful animal model for studying pathogenesis of intestinal, skeletal, and immunological manifestations of Ankylosing Spondylitis. Publication Status: Online-Only"
> "Q9EQH2-1","RefSeq","NP_109636.1","29559473","Study in hepatocellular carcinoma mouse models shows that Erap1 is critically involved in the process of tumor rejection and assumes a dual role by independently operating on both sides. Direct presentation of two MHC-I-restricted epitopes of a cancer-driving transplantation rejection antigen through Erap1 moderately affected tumor rejection by adoptively transferred T-cell receptor gene-modified T cells in each case."
> "Q9EQH2-1","RefSeq","NP_109636.1","29567213","Data provide the first evidence that ERAP1 associated with exosomes plays important roles in inflammatory processes via activation of macrophages."
> "Q9EQH2-1","RefSeq","NP_109636.1","12368856","Identification of ERAAP, the aminopeptidase associated with antigen processing in the endoplasmic reticulum (ERAAP)"
9582a12765
> "Q9CWM2-1","RefSeq","NP_082299.1","16546331","The evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein Cdca4 was studied."
9585a12769,12771
> "Q9WTJ6-1","RefSeq","NP_001273487.1","14648882","Data suggest that tesmin transcription may be controlled by two different mechanisms during male and female meiosis."
> "Q9WTJ6-1","RefSeq","NP_001273487.1","12606435","Tesmin is involved in multiple stages of spermatogenesis and spermiogenesis"
> "Q9WTJ6-1","RefSeq","NP_001273487.1","11803038","Regulation of the tesmin nucleocytoplasmic shuttling by the effect of metal stress"
9589a12776,12779
> "Q9CRD4-1","RefSeq","NP_081073.1","25297099","These findings reveal the essential roles of dysbindin and CaMKIIalpha in the stabilization of dendritic protrusions"
> "Q9CRD4-1","RefSeq","NP_081073.1","18096156","Thus, we have identified NKIP as an important novel protein that interacts to the NKA complex, influencing cellular ion balance, induction of apoptosis and neuronal differentiation.(NKIP PROTEIN, MOUSE)"
> "Q64368-1","RefSeq","NP_034151.3","29883445","The 3'-UTR-dependent suppression of DAZL in mouse follicular oocytes is required for the progression of normal pre-implantation development. Publication Status: Online-Only"
> "Q64368-1","RefSeq","NP_034151.3","23298641","Alternative splicing of exon8 of mDazl leads to the generation of the novel splice variant, Dazl-Delta8."
9601,9603d12790
< "Q9JI57-1","RefSeq","NP_001074931.1","29320702","GTF2IRD1 represses the transcription of transforming growth factor beta-dependent pro-fibrosis genes by recruiting PRDM16 and EHMT1 onto their promoter/enhancer regions."
< "Q9JI57-1","RefSeq","NP_001074931.1","27295951","The absence of GTF2IRD1 is associated with increased expression of genes involved in cellular proliferation, including growth factors consistent with the observed phenotype of extreme thickening of the epidermis. Publication Status: Online-Only"
< "Q9JI57-1","RefSeq","NP_001074931.1","27239038","The mis-regulation of genes downstream of GTF2IRD1, including TbetaR2 and BMPR1b, also individually promoted mammary cancer development, and silencing of TbetaR2 suppressed GTF2IRD1-driven tumor promotion."
9604a12792,12798
> "P15806-1","RefSeq","NP_035678.3","30659202","E47 and GR co-occupy metabolic promoters and enhancers. E47 is needed for the efficient recruitment of GR and coregulators such as Mediator to chromatin. Publication Status: Online-Only"
> "P15806-1","RefSeq","NP_035678.3","29966657","Upregulation of lncRNA CASC15 induced by VDR transcription factor facilitates cardiac hypertrophy via miR-432-5p/TLR4 axis."
> "P15806-1","RefSeq","NP_035678.3","29703840","Data show that inhibitor of DNA binding 2 protein (ID2) limited chromatin accessibility at transcription factor E2A protein binding sites near naive T lymphocyte-associated genes."
> "P15806-1","RefSeq","NP_035678.3","29440362","Continued Id2 regulation of E-protein activity is required to maintain the KLRG1(hi) CD8(+) T cell population after lymphocytic choriomeningitis virus infection."
> "Q9CRB6-1","RefSeq","NP_080757.1","29901777","The suppression of beta-catenin in uterus under the condition of transient knockdown of TPPP3 and the co-immunoprecipitation experiment revealed that regulation of beta-catenin was mediated via TPPP3 during implantation"
> "Q9CRB6-1","RefSeq","NP_080757.1","20571904","Findings suggested that the TPPP3 gene played an important role in tumorigenesis and metastasis, and it could potentially become a novel target for cancer therapy"
> "Q9CRB6-1","RefSeq","NP_080757.1","19235716","Onset of Tppp3 expression in joints coincides with cavitation, representing a molecular marker that can be used to indicate this stage in joint transition in joint differentiation"
9607a12802,12803
> "P51150-1","RefSeq","NP_033031.2","29907658","The majority of dendritic LAMP1 endosomes are not degradative lysosomes and terminal degradation of dendritic cargos such as Nsg1, Nsg2, and DNER requires Rab7-dependent transport in dendritic Rab7 late endosomes to somatic lysosomes."
> "P51150-1","RefSeq","NP_033031.2","29712939","A3 directly interacted with the GDP-bound forms of Rab7 and Rab27A. These findings reveal a novel role for the proton pump V-ATPase in secretory lysosome trafficking and an unexpected mechanistic link with Rab GTPases. Publication Status: Online-Only"
9619a12816,12817
> "Q9WUZ9-1","RefSeq","NP_031673.2","24859727","Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 regulation: cytochrome CYP2A5, GSTM3, GSTM1, ENTPD5,UDPGDH, and EPHX1."
> "Q9WUZ9-1","RefSeq","NP_031673.2","21074248","During a study using the embryonic fibroblasts from the PTEN null mice ENTPD5, is found to be upregulated by AKT activation; this enzyme seems to mediate many of the observed cancer-related phenotypes associated with AKT activation."
9625,9626d12822
< "Q60520-2","RefSeq","NP_001103821.1","29733394","Sin3a interacted with Tet1 to facilitate the transcription of a set of their co-target genes in embryonic stem cells."
< "Q60520-2","RefSeq","NP_001103821.1","29494759","These findings together suggest that SIN3A has a critical role in regulation of synaptic plasticity and might act as a potential therapeutic target to rescue memory decline during amnesia and other neuropsychiatric pathologies"
9637d12832
< "O08644-1","RefSeq","NP_001139823.1","28262839","Using an EphB6 mouse knockout model we found that the loss of EphB6 does not initiate intestinal tumorigenesis and is not involved in the early tumor progression through the adenoma-to-carcinoma transition. Publication Status: Online-Only"
9638a12834,12838
> "P29352-1","RefSeq","NP_033005.1","30054208","The data point to two related but distinct mechanisms by which PTPN22 regulates LFA-1 dependent signals to enhance Th1 development, highlighting how perturbations to PTPN22 function over time to regulate the balance of the immune response."
> "P29352-1","RefSeq","NP_033005.1","29666305","The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases [Review]. Review article Publication Status: Online-Only"
> "P29352-1","RefSeq","NP_033005.1","29116089","PTPN22 role in CD8-positive t cells activation. Publication Status: Online-Only"
> "P29352-1","RefSeq","NP_033005.1","29040339","PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells. Publication Status: Online-Only"
> "Q32MD9-1","RefSeq","NP_067314.2","30487570","The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression Publication Status: Online-Only"
9640a12841,12850
> "P20863-1","RefSeq","NP_032133.2","26212015","Epigenetic silencing of GDF1 abrogates the growth-inhibitory SMAD signaling and renders proliferation advantage to gastric epithelial cells during carcinogenesis"
> "P20863-1","RefSeq","NP_032133.2","25726944","GDF1 in the heart is a novel mediator that protects against the development of post-infarction cardiac remodelling via negative regulation of the MEK-ERK1/2 and Smad signalling pathways."
> "Q8C1F4-1","RefSeq","NP_084441.3","30579596","Chondroitin sulfate N-acetylgalactosaminyltransferase 2 is functionally involved in the progression of atherosclerosis both in its early and advanced stages."
> "Q80U23-1","RefSeq","NP_937857.1","28891816","SNPH is a stress-regulated mitochondrial switch of the cell proliferation-motility balance in cancer, and its pathway may represent a therapeutic target."
> "Q80U23-1","RefSeq","NP_937857.1","28472658","Stressed mitochondria are removed from axons triggered by the bulk release of mitochondrial anchoring protein syntaphilin via a new class of mitochondria-derived cargos independent of Parkin, Drp1, and autophagy."
> "Q80U23-1","RefSeq","NP_937857.1","27370822","DISC1 in association with SNPH is a component of a modulatory complex that determines mitochondrial anchoring in response to neuronal activation. Publication Status: Online-Only"
> "Q80U23-1","RefSeq","NP_937857.1","25834054","SNPH deletion produces striking benefits in the Shiverer mouse by prolonging survival, reducing cerebellar damage, suppressing oxidative stress, and improving itochondrial health. Erratum:[J Neurosci. 2015 Aug 12;35(32):11458]"
> "Q80U23-1","RefSeq","NP_937857.1","23857772","SNPH is required for activity-dependent regulation of mitochondrial transport."
> "Q80U23-1","RefSeq","NP_937857.1","19641106","Our studies suggest an unexpected role for LC8 and provide new mechanistic insights into how SNPH and LC8 together immobilize mitochondria through a dynamic interaction between the docking receptor and axonal cytoskeleton."
> "Q80U23-1","RefSeq","NP_937857.1","18191227","Here, we report a role for axon-targeted syntaphilin (SNPH) in mitochondrial docking through its interaction with microtubules. Axonal mitochondria that contain exogenously or endogenously expressed SNPH lose mobility."
9642a12853,12857
> "Q9Z2G9-1","RefSeq","NP_001139525.1","25530119","Data suggest that TIP30 plays a negative regulatory role in oligodendroglial differentiation."
> "Q9Z2G9-1","RefSeq","NP_001139525.1","25175814","Overexpression or knockdown of Htatip2 in hepatocytes affected fatty acid storage and oxidation, consistent with a novel role in mediating the differential effects of PKC isoforms on lipid metabolism."
> "Q9Z2G9-1","RefSeq","NP_001139525.1","24853420","TIP30 is a key regulator for maintaining ER(+) and ER(-)luminal pools in the mammary luminal lineage, and loss of it promotes expansion of ER(+) luminal progenitors and mature cells and ER(+) mammary tumorigenesis. Publication Status: Online-Only"
> "Q9Z2G9-1","RefSeq","NP_001139525.1","22733137","TIP30 functions as a tumor suppressor to inhibit EGFR cytoplasmic and nuclear signaling and suppress adenocarcinogenesis in the lung."
> "Q9Z2G9-1","RefSeq","NP_001139525.1","21252234","TIP30 complex regulates EGFR endocytosis by facilitating the transport of V-ATPases from trans-Golgi network to early endosomes."
9654a12870,12871
> "P12032-1","RefSeq","NP_035723.2","30572657","The aim of this study was to determine whether Acanthamoeba spp. may affect the levels of matrix metalloproteinases (MMP-2,-9), their tissue inhibitors (TIMP-1,-3) and MMP-9/TIMP-1, MMP-2/TIMP-3 ratios in the cerebral cortex and hippocampus, in relation to the host's immunological status. Publication Status: Online-Only"
> "P12032-1","RefSeq","NP_035723.2","30167842","The data suggest that Timp1 promotes the immune response in the lungs after influenza infection facilitating an injurious phenotype as a result of influenza infection."
9663a12881
> "Q60899-1","RefSeq","NP_034616.1","31013625","We demonstrated HuD downregulation and HuB upregulation in DRG sensory neurons induced by diabetes, which might be correlated with altered post-transcriptional control of RNAs involved in the regulation of thermal hypoalgesia condition caused by the advanced diabetic neuropathy. Publication Status: Online-Only"
9673,9676c12891,12894
< "Q80U62-1","RefSeq","NP_001186967.1","30783089","Rubicon role in aging and autophagy. Publication Status: Online-Only"
< "Q80U62-1","RefSeq","NP_001186967.1","28933590","Silencing Rubcn, preventing EGFR activity or directly inducing autophagy in retinal pigment epithelial cells by starvation inhibits phagocytic degradation of photoreceptor outer segments."
< "Q80U62-1","RefSeq","NP_001186967.1","19270696","Two Beclin 1 associated proteins, Atg14L and Rubicon, were identified."
< "Q80U62-1","RefSeq","NP_001186967.1","19270693","Beclin 1 and its binding proteins orchestrate the precise function of the class III PI(3)K in regulating autophagy at multiple steps."
---
> "Q99MU3-1","RefSeq","NP_062629.3","30651342","The results reveal an unrecognized role of ADAR1 in DC subset homeostasis and unveils the cell type-specific effects of RNA editing."
> "Q99MU3-1","RefSeq","NP_062629.3","30669342","ADAR1p150 plays a key role in complexing with Dicer and promoting the expression of miRNA-222, the latter of which suppresses the expression of the target gene PTEN during VMC. Our work reveals a previously unknown role of ADAR1p150 in gene expression in VMC. Publication Status: Online-Only"
> "Q99MU3-1","RefSeq","NP_062629.3","30559380","ADAR1 functions as a checkpoint that limits anti-tumour immunity by preventing the sensing of endogenous dsRNA. Loss of function of ADAR1 improves responses to PD-1 blockade and overcomes common mechanisms of resistance to immunotherapy."
> "Q99MU3-1","RefSeq","NP_062629.3","28960389","ADAR1 functions other than RNA editing are reviewed. Review article"
9681d12898
< "Q80TL4-1","RefSeq","NP_001333455.1","27145804","GINIP is predominantly expressed by small nonpeptidergic nociceptive neurons and that nerve injury triggers loss of GINIP expression. Publication Status: Online-Only"
9701a12919,12929
> "Q9CPU0-1","RefSeq","NP_079650.3","28623132","These data indicate that Glo1 knockout reduces anxiety-like behavior, but increases depression-like behavior."
> "Q9CPU0-1","RefSeq","NP_079650.3","27956549","Alternative detoxification of methylglyoxal in GLO1(-/-) is achieved by increased catalytic efficiency of aldose reductase toward hemithioacetal (product of glutathione and methylglyoxal ), which is most likely caused by S-nitrosylation of aldose reductase."
> "Q9CPU0-1","RefSeq","NP_079650.3","28170200","The objective of the present study was to detect whether overexpression of methylglyoxal-metabolizing enzyme glyoxalase-1 (GLO1), which reduces reactive oxygen species in Diabetic Adipose-Derived Stem Cells, can restore their proangiogenic function in a streptozotocin-induced diabetic mice model of critical limb ischemia."
> "Q9ESC8-1","RefSeq","NP_291043.1","25282333","Define a specific pairing of two amino acids that creates a salt bridge between MLLT1/3 and AFF proteins that is critically important for MLL-mediated transformation of HPCs"
> "Q9ESC8-1","RefSeq","NP_291043.1","22528490","AFF4 may therefore help to maintain activation of AMPK downstream signaling under conditions of prolonged stimulation with ghrelin, such as during fasting."
> "Q9ESC8-1","RefSeq","NP_291043.1","18039856","In the absence of Runx1 on the silencer, P-TEFb interacts with the transcription complex, forming a different chromatin loop between the enhancer and the promoter, which leads to the expression of the CD4 gene"
> "Q9ESC8-1","RefSeq","NP_291043.1","16024815","AF5q31 (Aff4) is a transcriptional regulator in testicular somatic cells and is essential for male germ cell differentiation and survival."
> "Q9QZB1-1","RefSeq","NP_067349.2","29440403","RGSz1 function suppression optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/beta-catenin pathway"
> "Q9QZB1-1","RefSeq","NP_067349.2","11882662","Analysis of in vitro microtubule polymerization/depolymerization showed that binding of RGSZ1 to SCG10 effectively blocked the ability of SCG10 to induce microtubule disassembly"
> "G3X9X1-1","RefSeq","NP_666070.2","29331106","This investigation indicates that Kbtbd2 is an inhibitory molecule for the tumoricidal activity of KIL C.2 Natural killer cells and perhaps intratumoral Natural killer cells."
> "G3X9X1-1","RefSeq","NP_666070.2","27708159","KBTBD2 is an essential regulator of the insulin-signaling pathway, modulating insulin sensitivity by limiting p85alpha abundance."
9709c12937,12941
< "Q9JLC6-1","RefSeq","NP_059072.1","30515906","Upregulation of TEF expression significantly retarded Bladder Cancer cell growth by inhibiting the G1/S transition via regulating AKT/FOXOs signalling."
---
> "Q9EPW0-1","RefSeq","NP_766559.2","28409542","This study shows that FcgammaRIIb drives the sequential dephosphorylation system comprising SHIP1/2 and Inpp4a, and accelerates phagosome acidification"
> "Q9EPW0-1","RefSeq","NP_766559.2","27252170","This study shows that the myeloid Inpp4a-knockout mice display impaired bacteria clearance due to decreased inflammatory cytokine production"
> "Q9EPW0-1","RefSeq","NP_766559.2","25907855","This study showed that spontaneous Inpp4a mutations causing cerebellar pathology are impaired in motor functions during the neonatal period."
> "Q9EPW0-1","RefSeq","NP_766559.2","22986054","These results suggest a novel mechanism of action of resveratrol in attenuating asthma phenotype by downregulating PI3K-Akt pathway via upregulating INPP4A."
> "Q9EPW0-1","RefSeq","NP_766559.2","20463662","INPP4A represents the first signalling protein with a function in neurons to suppress excitotoxic cell death"
9715a12948
> "P11416-1","RefSeq","NP_033050.2","30650370","This study shows that RAR-alpha represses a Th9 transcriptional and epigenomic program to reduce allergic pathology"
9719,9722c12952,12958
< "Q9JJ57-1","RefSeq","NP_001177814.1","20678225","KChIP1 is a synaptic protein that regulates behavioral anxiety by modulating inhibitory synaptic transmission. Publication Status: Online-Only"
< "Q9JJ57-1","RefSeq","NP_001177814.1","17640927","Aromatic cluster in exon1b modulates the transitions towards and from the closed inactivated states and the steady state distribution over the respective states"
< "Q9JJ57-1","RefSeq","NP_001177814.1","15363885","KChIP1 was expressed in a subpopulation of neurons widely distributed in brain and enriched in Purkinje cells of the cerebellum and in the reticular thalamic and medial habenular nuclei."
< "Q9JJ57-1","RefSeq","NP_001177814.1","14572458","Differential expression of KCh1P1 splice variants can shape the function of Kv4.2 channels involved in protection against back propagating action potentials in dendritic spines."
---
> "Q8VEL2-1","RefSeq","NP_081125.2","30412589","MTMR14 deletion impairs male fertility by causing decreased muscle force of the vas deferens and intracellular calcium imbalance. Publication Status: Online-Only"
> "Q8VEL2-1","RefSeq","NP_081125.2","27807764","Data (including data from studies in knockout mice) suggest that Mtmr14 plays role in lipid metabolism and inflammation in liver, skeletal muscle, and adipose tissue in obesity induced by high-fat diet (HFD); here, Mtmr14 deficiency in knockout mice accelerates HFD-induced inflammation and metabolic dysfunction (obesity, hyperglycemia, and hyperlipidemia)."
> "Q8VEL2-1","RefSeq","NP_081125.2","24623267","Propose that defect of MTMR14 promotes autophagy and cell proliferation in MEFs"
> "Q8VEL2-1","RefSeq","NP_081125.2","21930146","In young Mtmr14 KO mice (12 weeks). The T-tubule dysmorphology (swollen and elongated) could explain, in part, the defects in Ca2thorn excitationcontraction machinery observed in previous studies."
> "Q8VEL2-1","RefSeq","NP_081125.2","20817957","A knockout mice were more susceptible to exercise-induced muscle damage, a trademark of muscle functional changes in older subjects"
> "Q8VEL2-1","RefSeq","NP_081125.2","19465920","Data report that mice deficient in the newly identified phosphatidylinositol phosphate phosphatase MIP/MTMR14 (muscle-specific inositol phosphatase) show muscle weakness and fatigue."
> "Q99KK7-1","RefSeq","NP_598564.2","24216478","The cellular peptidases dipeptidyl peptidase 3 (DPP-3) and thimet oligopeptidase 1 (TOP-1), both of which are present in nonimmunogenic necrotic cells, eliminated proteasomal degradation products and blocked Ag cross-presentation"
9729a12966,12969
> "P19426-1","RefSeq","NP_613046.2","29847629","In every case, mice were found to be homozygous for the rd8 mutation, which informed the decision not to perform genotyping for this allele as a matter of routine, as the commercial mouse providers maintained their breeding schemes."
> "Q9CZX8-1","RefSeq","NP_075622.1","27424793","Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice. Results suggest an involvement of RP S19 oligomers in some anxiety-like behavior, especially grooming behavior."
> "Q9CZX8-1","RefSeq","NP_075622.1","27643579","Rps19 mutant shows behavioural phenotypes resembling that of the human Diamond-Blackfan anaemia syndrome."
> "Q9CZX8-1","RefSeq","NP_075622.1","12393682","RPS19 mRNA and protein expression were shown to decrease during terminal erythroid differentiation."
9739,9740d12978
< "Q9D842-1","RefSeq","NP_001163960.1","27875275","The downregulation of histone chaperone Aprataxin PNK-like factor (APLF) promotes reprogramming by augmenting the expression of E-cadherin. Erratum:[J Cell Sci. 2018 Apr 19;131(8):. PMID: 29674330]"
< "Q9D842-1","RefSeq","NP_001163960.1","21211721","APLF has a role in chromosomal DNA double-strand break repair."
9743a12982,12985
> "Q61139-1","RefSeq","NP_032820.2","27923657","PC7 has a critical role in normal processing of cholecystokinin in mouse brain"
> "Q61139-1","RefSeq","NP_032820.2","26416966","PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation."
> "Q61139-1","RefSeq","NP_032820.2","24101515","Data show that BDNF and PC7 mRNAs are colocalized in hippocampus and amygdala and that mature BDNF protein levels are reduced in these brain areas in proprotein convertase PC7 knockout mice."
> "Q61139-1","RefSeq","NP_032820.2","23686857","Overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner"
9754a12997,13003
> "Q9JHG2-1","RefSeq","NP_997532.1","28624805","Our results indicate that Rcan2 and estradiol might regulate body weight through different mechanisms in female mice. Rcan2 increases food intake and promotes weight gain, while estradiol increases energy expenditure possibly by regulating physical activity."
> "Q9JHG2-1","RefSeq","NP_997532.1","27917924","RCANs play critical roles in bone homeostasis by regulating both osteoclastogenesis and osteoblastogenesis, and they serve as inhibitors for calcineurin-NFATc1 signaling both in vivo and in vitro. Publication Status: Online-Only"
> "Q9JHG2-1","RefSeq","NP_997532.1","27604858","Rcan2 and Rps6kb1 mutations both affect growth and body weight of mice, though likely through different mechanisms"
> "Q8C0C0-1","RefSeq","NP_955520.1","30146259","Zhx2 is expressed in developing retina. Zhx2 is essential for subsets of bipolar cell proper differentiation. Overexpression of Zhx2 showed perturbation of bipolar differentiation."
> "Q8C0C0-1","RefSeq","NP_955520.1","28258223","Zhx2 is a novel regulator of Mup expression; Zhx2 activates as well as represses expression of target genes"
> "Q8C0C0-1","RefSeq","NP_955520.1","27197076","Additional Cyp genes are disregulated in the absence of Zhx2."
> "Q8C0C0-1","RefSeq","NP_955520.1","23583303","NFAT1 protein activation can shift oncogenic Ras/Raf/MEK/ERK signaling to acting as a tumor suppressor pathway."
9757a13007
> "Q8K2D3-1","RefSeq","NP_722494.1","20051463","Induction of 14-3-3 binding to EDC3 causes morphological changes in processing body structures, inhibition of microRNA-mediated mRNA post-transcriptional regulation, and alterations in the protein- protein interactions of EDC3."
9763a13014,13016
> "Q9QXS1-1","RefSeq","NP_958796.2","18541706","Plectin 1b both forms a mitochondrial signaling platform and affects organelle shape and network formation by tethering mitochondria to intermediate filaments."
> "Q9QXS1-1","RefSeq","NP_958796.2","17389230","We propose a model in which plectin acts as a universal mediator of desmin intermediate filament anchorage at the sarcolemma and Z-disks."
> "Q9QXS1-1","RefSeq","NP_958796.2","12542521","Expression of plectin 1a, but not of its N-terminal fragment alone, or of a third alternative full length isoform (plectin 1), restored the reduced number of hemidesmosome-like stable anchoring contacts in cultured plectin-null keratinocytes"
9769a13023,13024
> "P29341-1","RefSeq","NP_032800.2","29701755","PIWIL1 augments protein translation with PABPC1 in the presence of 3'-UTRs of post-meiotic mRNAs. While both the N-terminal RNA recognition motif (RRM) domain and the central linker region of PABPC1 stimulate translation, only the PIWI Argonaute and Zwille (PAZ) domain of PIWIL1 positively affects translation of reporter mRNAs."
> "P29341-1","RefSeq","NP_032800.2","29590218","These results suggest that PABP interacts with HuD in basal glucose conditions making translation inhibitory complex, however upon glucose stimulation this association is affected and PABP is acted upon by PDI resulting in stimulation of insulin translation. Publication Status: Online-Only"
9781a13037,13039
> "Q8C5Q4-1","RefSeq","NP_848815.2","25184340","Grsf1 controls translation of the protein Use1, possibly by positioning the 40S ribosomal subunit and associated translation factors in front of the translation start site. Publication Status: Online-Only"
> "Q8C5Q4-1","RefSeq","NP_848815.2","18593884","Grsf1 up-regulates translation of GPx4 mRNA and implicate the two proteins in embryonic brain development."
> "Q8C5Q4-1","RefSeq","NP_848815.2","15857914","Grsf1 is important for axial elongation, mid/hindbrain development and axial mesoderm specification."
9784,9788d13041
< "Q5U4C1-1","RefSeq","NP_001004359.1","25657005","Present the First low resolution solution structure of myostatin-free and myostatin-bound states of GASP-1 and GASP-2"
< "Q5U4C1-1","RefSeq","NP_001004359.1","25277978","Gasp-1 overexpression resulted in increased myostatin expression."
< "Q5U4C1-1","RefSeq","NP_001004359.1","24019467","GASP-1 and GASP-2 are important modulators of GDF-11 and MSTN activity in vivo."
< "Q5U4C1-1","RefSeq","NP_001004359.1","23046573","Overexpression of Gasp1 led to an increase in muscle mass observed not before day 15 of postnatal life. Publication Status: Online-Only"
< "Q5U4C1-1","RefSeq","NP_001004359.1","21091868","The pattern of behavioral deficits observed in GASP-1-deficient mice is coherent with current knowledge of the role of striatal G protein-coupled receptor(GPCR)s in acquisition/expression of skilled behavior and motivation."
9790a13044,13048
> "Q569Z6-1","RefSeq","NP_666265.3","28770354","These results indicate that THRAP3 negatively regulates SOX9 transcriptional activity as a cofactor of a SOX9 transcriptional complex during chondrogenesis."
> "Q569Z6-1","RefSeq","NP_666265.3","24043798","TRAP150 is a selective coactivator for CLOCK-BMAL1, promoting its binding to target genes and linking it to the transcriptional machinery at target-gene promoters."
> "O35216-1","RefSeq","NP_031707.1","28756949","Centromeres with more satellite repeats house more nucleosomes that confer centromere identity, containing the histone H3 variant CENP-A, and bias their segregation to the egg relative to centromeres with fewer repeats."
> "O35216-1","RefSeq","NP_031707.1","28598437","CENP-A nucleosome retention at centromeres requires a core centromeric nucleosome complex where CENP-C clamps down a stable nucleosome conformation and CENP-N fastens CENP-A to the DNA. Publication Status: Online-Only"
> "O35216-1","RefSeq","NP_031707.1","28585134","The findings provide evidence that CENP-A is critical for the faithful chromosome segregation during mammalian oocyte meiosis."
9799a13058,13060
> "Q80XU8-1","RefSeq","NP_700437.2","27480238","SALM4 cis-interacts with SALM3, inhibits trans-synaptic SALM3 interaction with presynaptic LAR family receptor tyrosine phosphatases and suppresses SALM3-dependent presynaptic differentiation. Publication Status: Online-Only"
> "Q80XU8-1","RefSeq","NP_700437.2","20410109","Expression of SALM family proteins SALM3 and SALM5 in nonneural and neural cells induces both excitatory and inhibitory presynaptic differentiation in contacting axons."
> "Q80XU8-1","RefSeq","NP_700437.2","18585462","Data show that the C-terminal PDZ binding domains of synaptic adhesion-like molecules (SALMs)1-3 are required for neurite outgrowth, and that the N-termini of SALMs 2 and 4 are alsoinvolved in neurite outgrowth."
9802a13064,13067
> "Q9QXJ1-1","RefSeq","NP_033815.1","27734846","These data demonstrate a role for FE65 proteins at central and peripheral synapses. Publication Status: Online-Only"
> "Q9QXJ1-1","RefSeq","NP_033815.1","26276215","Jagged1 is a novel binding partner of Fe65, and Fe65 may act as a novel effector of Jagged1 signaling."
> "Q9QXJ1-1","RefSeq","NP_033815.1","26255939","Results provide strong evidence that Fe65 plays a role in DNA damage response and cell viability by epigenomic regulation of specific transcriptional programs activated upon genotoxic stress."
> "Q9QXJ1-1","RefSeq","NP_033815.1","25757569","Findings show that amyloid precursor protein-binding proteins FE65 and FE65L1 are essential for the maintenance of lens transparency."
9808a13074,13075
> "Q9JM96-1","RefSeq","NP_064390.1","29330091","Overexpression of CDC42EP4 in heterologous cells promotes cell spreading and partitioning of MYH10 to insoluble (i.e., active) fraction"
> "Q9JM96-1","RefSeq","NP_064390.1","26657011","This study suggests propose that the CDC42EP4/septin-based glial scaffold facilitates perisynaptic localization of GLAST and optimizes the efficiency of glutamate-buffering and clearance. Publication Status: Online-Only"
9813a13081,13083
> "Q99J83-1","RefSeq","NP_444299.1","30297526","Taken together, our results demonstrate that Atg5 favors Rickettsia australis infection in mouse macrophages in association with a suppressed level of IL-1beta production but not active autophagy flux. These data highlight the contribution of Atg5 in macrophages to the pathogenesis of rickettsial diseases. Publication Status: Online-Only"
> "Q99J83-1","RefSeq","NP_444299.1","30472709","MiR-376b downregulation promotes macrophage autophagy to relieve Renal Interstitial Fibrosis by negatively regulating Atg5 in mice with CKD."
> "Q8VCD6-1","RefSeq","NP_659114.2","20943918","REEP2 recruits sweet receptors into lipid raft microdomains localized near the taste cell's apical region, thereby improving G-protein-coupled receptor signaling and promoting receptor access to tastants arriving through the apical taste pore."
9834,9835d13103
< "Q3UNX5-1","RefSeq","NP_058566.3","25744306","Data suggest that expression of Acsm3 in adipose tissue can be regulated by dietary factors; here, expression of Acsm3 in white adipose tissue is down-regulated in obesity caused by high-fat diet."
< "Q3UNX5-1","RefSeq","NP_058566.3","12707288","Analysis of the role of the SA gene in blood pressure regulation."
9840,9843d13107
< "Q9D5T7-1","RefSeq","NP_001276461.1","29414051","Exogenous DSBs recruit the meiosis-specific homologous recombination repair machinery, are translocated to the axial elements, contribute to homology recognition, and that their repair is modulated by HORMAD1."
< "Q9D5T7-1","RefSeq","NP_001276461.1","19686734","Results suggest that also mammalian cells use a HORMA domain-containing protein (HORMAD1) as part of a surveillance system that monitors chromosomal synapsis or other interactions between homologs."
< "Q9D5T7-1","RefSeq","NP_001276461.1","19851446","HORMAD1 and HORMAD2 are depleted from synapsed chromosome axes with the help of TRIP13."
< "Q9D5T7-1","RefSeq","NP_001276461.1","15567723","The expression pattern of Nohma suggests that it may be a critical regulatory protein in germ cell meiosis."
9848a13113,13115
> "P97463-1","RefSeq","NP_032764.1","29176874","NRTN causes presynaptic and postsynaptic restoration of the nigrostriatal dopaminergic system after a 6-OHDA-induced chronic lesion. Publication Status: Online-Only"
> "P97463-1","RefSeq","NP_032764.1","28825602","These results indicate that NRTN contributes to an increase in the epidermal density of nonpeptidergic nerves in the imiquimod-induced psoriasis model, and this increase may be a factor in chronic itch."
> "P97463-1","RefSeq","NP_032764.1","19176599","Report structural and functional cardiac cholinergic deficits in adult neurturin knockout mice."
9867d13133
< "Q2WF71-1","RefSeq","NP_001135393.1","18585462","Data show that the C-terminal PDZ binding domains of synaptic adhesion-like molecules (SALMs)1-3 are required for neurite outgrowth, and that the N-termini of SALMs 2 and 4 are alsoinvolved in neurite outgrowth."
9875a13142,13143
> "P62500-1","RefSeq","NP_997535.2","26752201","These results suggested that TSC-22 could counteract the protective effect of GILZ on IL-2-deprivation-induced apoptosis."
> "P62500-1","RefSeq","NP_997535.2","26872059","High TSC-22 expression is associated with obesity, splenic abnormality and B cell lymphoma."
9882a13151
> "P13595-1","RefSeq","NP_035005.2","29999523","CD56(neg) Natural Killer cells constitute functionally competent cells sharing many features of bona fide CD56(dim) Natural Killer cells in healthy individuals, but with some distinct characteristics."
9883a13153,13161
> "Q3UN02-1","RefSeq","NP_001171439.1","28751023","Lycat regulates TGF-beta mediated lung fibroblast differentiation in pulmonary fibrosis."
> "Q3UN02-1","RefSeq","NP_001171439.1","26604221","Alcat1 is destabilized in epithelia by lipopolysaccharide (LPS) impairing mitochondrial function."
> "Q3UN02-1","RefSeq","NP_001171439.1","26251360","Differential reduction in cardiac and liver monolysocardiolipin acyltransferase-1 and reduction in cardiac and liver tetralinoleoyl-cardiolipin in the alpha-subunit of trifunctional protein heterozygous knockout mice"
> "Q3UN02-1","RefSeq","NP_001171439.1","25203315","Pathological cardiolipin remodeling by ALCAT1 linked to the pathogenesis of nonalcoholic fatty liver diseases"
> "Q3UN02-1","RefSeq","NP_001171439.1","24779708","LYCAT expression was altered in peripheral blood mononuclear cells and outcome in pulmonary fibrosis."
> "Q3UN02-1","RefSeq","NP_001171439.1","19372376","Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~40%."
> "Q3UN02-1","RefSeq","NP_001171439.1","17675553","Mouse Lycat plays an important role in the early specification of hematopoietic and endothelial cells."
> "Q3UN02-1","RefSeq","NP_001171439.1","15152008","Identification and characterization of a gene that encodes an acyl-CoA:lysocardiolipin acyltransferase 1"
> "P01326-1","RefSeq","NP_032413.1","20153322","Alternative splicing of insulin mRNA in mice could result in an additional level of regulation in insulin biosynthesis."
9890a13169,13175
> "Q3TL44-1","RefSeq","NP_848507.2","30804553","Identification of NLRX1 as a novel mitophagy receptor for L. monocytogenes-induced mitophagy."
> "Q3TL44-1","RefSeq","NP_848507.2","30191480","Endogenous SARM1 was equally distributed in the cytosol and the mitochondrial matrix, where association with NLRX1 occurred. In these cells, the apoptotic role of NLRX1 was fully dependent on SARM1, indicating that SARM1 was downstream of NLRX1 in apoptosis regulation."
> "Q3TL44-1","RefSeq","NP_848507.2","30559741","NLRX1 facilitates LAP by interacting with TUFM which associates with autophagic proteins ATG5-ATG12 for LAPosome formation. Publication Status: Online-Only"
> "Q3TL44-1","RefSeq","NP_848507.2","29535731","This study shows that NLRX1 modulates immunometabolic mechanisms controlling the host-gut microbiota interactions during inflammatory bowel disease Publication Status: Online-Only"
> "Q3TL44-1","RefSeq","NP_848507.2","21703540","NLRX1 interacts with TRAF6 and inhibits NF-kappaB activation"
> "Q3TL44-1","RefSeq","NP_848507.2","21703539","Study identifies a previously unrecognized role for NLRX1 in the negative regulation of TLR-induced NF-kappaB activation by dynamically interacting with TRAF6 and the IKK complex"
> "Q3TL44-1","RefSeq","NP_848507.2","20959452","The presence of NLRX1 is required for optimal chlamydial growth and reactive oxygen species production"
9896a13182
> "P70362-1","RefSeq","NP_035802.3","26112410","The study revealed a regulatory role of the p97-Npl4-Ufd1 complex in regulating a partial degradation of the NF-kappaB subunit p100."
9899a13186
> "Q61361-1","RefSeq","NP_031555.2","30253762","Genetic deletion of brevican, one of the main components, resulted in a massive degradation of extracellular matrix baskets at inner hair cells, a significant impairment in spatial coupling of pre- and postsynaptic elements and mild impairment of hearing. Publication Status: Online-Only"
9900a13188,13189
> "P60904-1","RefSeq","NP_058055.1","28424476","Results indicate that by assisting local lysosome/proteasome processes, CSPalpha-mediated removal of toxic proteins via extracellular vesicles plays a central role in synaptic proteostasis. Publication Status: Online-Only"
> "P60904-1","RefSeq","NP_058055.1","27881461","These data show that neurodegenerative processes associated with lysosomal dysfunction may be presynaptically initiated by a concomitant reduction in alpha-synuclein and CSPalpha levels at nerve terminals."
9904a13194
> "P15209-1","RefSeq","NP_032771.1","30747207","Compared with trkB.T1 wild type (WT) mice, the differentially expressed genes (DEGs) in trkB.T1 KO mice following spinal cord injury at different time points were screened out. The significant DEGs were subjected to function, coexpression and proteinprotein interaction (PPI) network analyses. Construction of a Venn diagram revealed the overlap of several DEGs in trkB.T1 KO mice under different conditions."
9908a13199,13200
> "Q03141-1","RefSeq","NP_073712.2","20733003","Knockout mice were protected against high-fat diet-induced obesity and displayed attenuated weight gain, complete resistance to hepatic steatosis, and improved glucose handling with decreased insulin secretion."
> "Q9DBS9-1","RefSeq","NP_082157.2","17303778","OSBP regulates hepatic TG metabolism and suggest the involvement of OSBP in the insulin signaling pathways that control hepatic lipogenesis."
9912a13205,13210
> "Q9CR75-1","RefSeq","NP_038777.2","30648117","This study shows that Fn14 deficiency effectively protects SCID mice from anti-dsDNA IgG-induced glomerular damage Publication Status: Online-Only"
> "Q9CR75-1","RefSeq","NP_038777.2","30033152","Fn14 was identified as a molecular link between sensory-driven gene expression and vision-sensitive refinement in the brain."
> "Q9CR75-1","RefSeq","NP_038777.2","29981796","Confirming its critical role in TWEAK signaling, silencing TRAF3IP2 inhibited TWEAK autoregulation, TWEAKR upregulation, p38 MAPK, NF-kappaB and AP-1 activation, inflammatory cytokine expression, MMP and TIMP1 activation, collagen expression and secretion, and importantly, proliferation and migration"
> "Q9CR75-1","RefSeq","NP_038777.2","28562476","Fn14 on PMVECs plays an important role in the progress of septic Acute Lung Injury. Fn14 blockade may prove to be an innovative lung-protective strategy for the treatment of septic Acute Lung Injury."
> "Q9CR75-1","RefSeq","NP_038777.2","12794080","Findings show that the Fn14/TWEAK receptor (TweakR) was not responsible for the osteoclastic effect of TWEAK on RAW cells"
> "Q9CR75-1","RefSeq","NP_038777.2","12529173","The cytoplasmic tail of this protein binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation."
9925c13223,13227
< "O08575-1","RefSeq","NP_001258891.1","30628662","Immunoglobulin enhancerbinding factor/hepatic leukemia factor oncogenic fusion protein (E2AHLF) enhances the EYA transcriptional coactivator and phosphatase 2 (Eya2) expression by binding to the promoter region containing the E2AHLFbinding consensus sequence. Eya2 knockdown in E2AHLFimmortalized cells resulted in reduced colonyforming efficiency."
---
> "Q9D9X8-1","RefSeq","NP_083643.1","26198801","Distinct from c-lysozyme by substituting two essential catalytic residues (E35T/D52N), and by forming helical filaments approximately 75 A in diameter with a 25 A central pore comprised of six monomers per helix turn repeating every 33 A"
> "Q9D9X8-1","RefSeq","NP_083643.1","25038051","Female mice immunized with SPRASA had profound infertility following timed matings and those mice that did become pregnant had reduced fetal viability."
> "Q9D9X8-1","RefSeq","NP_083643.1","22206759","Data show that SAS1B/SAS1R (Sperm Acrosomal SLLP1 Binding/Sperm Acrosomal SLLP1 receptor) bound to sperm acrosomal protein SlLP1 with high affinity."
> "Q9D9X8-1","RefSeq","NP_083643.1","15982649","This study demonstrates the retention of mouse sperm lysozyme-like protein (mSLLP1) in the equatorial segment of spermatozoa following the acrosome reaction and a role for mSLLP1 in sperm-egg binding and fertilization."
> "Q6QIY3-1","RefSeq","NP_033160.2","30755524","We find that approximately 80% of neurons responsive to cold down to 1 degrees C do not express NaV1.8, and that the genetic deletion of NaV1.8 does not affect the relative number, distribution, or maximal response of cold-sensitive neurons. Furthermore, the deletion of NaV1.8 had no observable effect on transient cold-induced (>/=5 degrees C) behaviors in mice, as measured by the cold-plantar, cold-plate (5 and 10 deg..."
9940a13243,13246
> "P35802-1","RefSeq","NP_705809.1","28275160","GPM6a induces the clustering of lipid rafts and acts as a signal transducer that responds to extracellular signals."
> "P35802-1","RefSeq","NP_705809.1","24917275","This study demonistrated that M6a is essential for the support of neurite extension in developmental brain."
> "O54827-1","RefSeq","NP_033858.2","19894069","Data report that Atp10a is biallelically expressed in both the newborn and adult brain, and Atp10a allelic expression is insensitive to deletion or mutation of the PWS imprinting center."
> "O54827-1","RefSeq","NP_033858.2","12105293","Report the generation of the complete genomic structure"
9944,9949c13250,13255
< "Q8BND5-1","RefSeq","NP_001020116.1","29800099","Our study provides the first comprehensive comparisons between QSOX1 and QSOX2 in the mouse epididymis, revealing their distinct epididymal distribution, cellular localization, mechanisms of secretion and sperm membrane association"
< "Q8BND5-1","RefSeq","NP_001020116.1","29723491","The data indicated that QSOX1 is required 1) for a proper protein folding in the endo/sarcoplasmic reticulum (ER/SR) and 2) for resolution and protective response during acute stress."
< "Q8BND5-1","RefSeq","NP_001020116.1","27581528","Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms, in particular, by the serum QSOX1."
< "Q8BND5-1","RefSeq","NP_001020116.1","24475161","QSOX1 inhibits autophagy in breast cancer cells. Publication Status: Online-Only"
< "Q8BND5-1","RefSeq","NP_001020116.1","16160860","In seminiferous tubules, where a high level of expression was noticed, QSOX might play an important physiological role in sperm function and serve as a marker for the diagnosis of male infertility."
< "Q8BND5-1","RefSeq","NP_001020116.1","12354420","Cloned skin SOx cDNA and characterized it as one of the disulfide (S-S) cross-linking enzymes"
---
> "P70663-1","RefSeq","NP_034227.3","29084211","Low SPARCL1 expression promotes lung metastasis in osteosarcoma."
> "P70663-1","RefSeq","NP_034227.3","27721236","Tumor endothelial cells heterogeneity is regulated by SPARCL1, which promotes the cell quiescence and vessel homeostasis contributing to the favorable prognoses associated with Th1-tumor microenvironments colorectal carcinomas."
> "P70663-1","RefSeq","NP_034227.3","27317982","We could show that ablation of either candidate enhanced adipogenesis in visceral preadipocytes, while treatment of primary cultures with recombinant Sparcl1 and Dcn blocked adipogenesis in a dose dependent manner. In conclusion, our data suggests that the differences in adipogenesis between depots might be due to paracrine and autocrine feedback mechanisms which could in turn contribute to metabolic homeostasis"
> "P70663-1","RefSeq","NP_034227.3","26771491","Study shows that astrocyte-secreted hevin is a trans-synaptic linker that bridges presynaptic NRX1alpha with postsynaptic NL1B. This way, hevin organizes both pre- and postsynaptic specializations and aligns them across the synapse."
> "Q60592-1","RefSeq","NP_032667.2","16159897","MAST205 regulates NHE3 activity and, although the precise mechanism is yet to be determined, MAST205 appears to inhibit NHE3 activity through a phosphorylation-dependent mechanism."
> "Q60592-1","RefSeq","NP_032667.2","15308666","MAST205 functions as a scaffolding protein controlling TRAF6 activity and, therefore, plays an important role in regulating inflammatory responses."
9950a13257,13266
> "Q7TMS5-1","RefSeq","NP_036050.1","30042379","These results demonstrated that ATP-binding cassette transporter subfamily G member 2 (ABCG2) is a major transporter of the uremic toxin indoxyl sulfate. ABCG2 regulates the pathophysiological excretion of indoxyl sulfate and strongly affects Chronic kidney disease survival rates. Publication Status: Online-Only"
> "Q7TMS5-1","RefSeq","NP_036050.1","29574357","It is located in the blood-brain barrier limits the entry of endogenous compounds and xenobiotics into the brain, and its expression and activity are regulated by estrogen."
> "Q7TMS5-1","RefSeq","NP_036050.1","28990372","The hypothesis that ABCG2 plays a fundamental role during mESC differentiation or that regulation of the receptor by xenobiotics may be associated with altered mESC differentiation could not be supported."
> "Q7TMS5-1","RefSeq","NP_036050.1","28935760","Ultrasound reverses chemoresistance in breast cancer stem cell like cells by reducing ABCG2 expression. Publication Status: Online-Only"
> "Q7TMS5-1","RefSeq","NP_036050.1","28790147","Which raises the possibility that EGFR-inhibiting drugs may cause ABCG2-mediated DDIs."
> "P21126-1","RefSeq","NP_663380.1","30146258","The single point mutation of an aspartic acid to alanine (D122A) in the Ubl4A C-terminus abolishes its ability to bind the Arp2/3 complex. This mutation also destabilizes Ubl4A proteins susceptible to protease degradation."
> "P21126-1","RefSeq","NP_663380.1","29464742","The results uncovered GdX as a novel regulator in bone development and a potential candidate gene for skeletal dysplasias."
> "P21126-1","RefSeq","NP_663380.1","27998771","Ubl4A has a role in fibroblast and macrophage migration-associated pathophysiological processes"
> "P21126-1","RefSeq","NP_663380.1","26195787","Ubiquitin-like protein 4A (Ubl4A) plays a crucial role in insulin-induced Akt plasma membrane translocation."
> "P21126-1","RefSeq","NP_663380.1","25713138","Data indicate that the BAGS domain of BAG6 (Bcl-2-associated athanogene 6) interacts with the C-terminal domain of Ubl4a (ubiquitin-like protein 4a)."
9953d13268
< "P40226-1","RefSeq","NP_001166976.1","31301081","Study of hepatocarcinogenesis induced by diethylnitrosamine in B6C3F1 mice, the BrafV637E mutation, corresponding to the human BRAFV600E mutation, suggested that the TPO-mediated macroenvironmental changes involving the liver and bone marrow may promote proliferation of the BRAFV600E-mutated hepatocytes, but cause hematological, renal, and pulmonary disorders that lead to death."
9956a13272,13276
> "Q80ZK9-1","RefSeq","NP_955010.1","25088174","Adp is a positive modulator of myoblast differentiation."
> "Q80ZK9-1","RefSeq","NP_955010.1","17767906","Data show that the anti-obesity function of adipose (Adp) (worm Y73E7A.9, fly adp, and murine Wdtc1) is conserved from worms to mammals."
> "P28229-1","RefSeq","NP_032148.1","30355030","Cx45 is the connexin isoform mediating the entrainment of the contraction waves in lymphatic vessels."
> "P28229-1","RefSeq","NP_032148.1","29361518","The levels of mRNAs encoding Connexin43 or Connexin45 were not or were only marginally affected, respectively, by Clmp deficiency, the absence of CLMP caused a severe reduction of both proteins in smooth muscle cells of the intestine and of Connexin43 in the ureter. Publication Status: Online-Only"
> "P28229-1","RefSeq","NP_032148.1","28561933","Punctate labelling of Cx45 was faint in the cerebellar cortex molecular layer of wild-type mice and was increased in intensity in mice with Cx36 gene ablation. The vast majority of Cx36-puncta co-localized with Cx45-puncta, which in turn was associated with the scaffolding protein zonula occludens-1."
9957a13278,13280
> "Q9CQ20-1","RefSeq","NP_080800.1","21474539","MIG12 is a mediator for stimulation of lipogenesis by LXR activation in the liver"
> "Q9CQ20-1","RefSeq","NP_080800.1","18556348","The S14-R protein is a compensatory factor, at least partially responsible for the normal liver lipogenesis observed in the S14 null mouse"
> "Q9CQ20-1","RefSeq","NP_080800.1","15070402","Mig12 is expressed in the embryonic ventral midline and co-operates with Mid1 to stabilize microtubules Publication Status: Online-Only"
9985a13309,13319
> "Q9JL15-1","RefSeq","NP_061374.1","29800364","Galectin-8 regulates antibacterial autophagy through differential recognition of host glycans on damaged phagosomes."
> "Q9JL15-1","RefSeq","NP_061374.1","29259034","These findings identify gal-8 as a new physiologic player in the regulation of bone mass."
> "Q9JL15-1","RefSeq","NP_061374.1","28811319","Galectin-8 activates dendritic cells and stimulates antigen-specific immune response elicitation."
> "Q9JL15-1","RefSeq","NP_061374.1","21753146","A novel role for Gal-8 in collaboration with Gal-1 in plasma cell formation, and suggest the possibility of using distinct LacNAc ligands to modulate the function of Gals."
> "Q9JL15-1","RefSeq","NP_061374.1","21091438","The findings of the present study delineate the differential molecular requirements for Gal-8 activities on T-cells, and suggest a dual activity relying on activation state."
> "Q9JL15-1","RefSeq","NP_061374.1","19401394","Taken together, our findings support a distinctive role for locally produced Gal-8 as an enhancer of otherwise borderline immune responses and also suggest that Gal-8 might fuel the reactivity at inflammatory foci."
> "Q9JL15-1","RefSeq","NP_061374.1","17893094","Galectin-8 is expressed in the thymus in mouse, which suggests an active role for this lectin in shaping the mature T cell repertoire"
> "Q91ZV4-1","RefSeq","NP_080989.2","27404390","Demonstrate that chronic ethanol ingestion activates peroxisome proliferator-activated receptor gamma (PPARgamma) and its target gene, monoacylglycerol O-acyltransferase 1 (MGAT1) Publication Status: Online-Only"
> "Q91ZV4-1","RefSeq","NP_080989.2","26880786","A minimal role, if any, of MOGAT1 in liver TAG synthesis"
> "Q91ZV4-1","RefSeq","NP_080989.2","24595352","Inactivation of hepatic MGAT activity, which is markedly increased in obese mice, improved glucose tolerance and hepatic insulin signaling independent of changes in body weight, intrahepatic DAG and TAG content, and PKC signaling."
> "Q91ZV4-1","RefSeq","NP_080989.2","12077311","MGAT1 identified, biochemical characteristics and tissue distribution reported."
9992a13327
> "Q99L43-1","RefSeq","NP_619592.1","16023307","Cds2 showed a ubiquitous pattern of expression and was mapped to chromosome 2G1."
10004,10008c13339,13340
< "Q8K2F0-1","RefSeq","NP_001107045.1","28733670","Using pharmacological assay and RNA interference, BRD3 down-regulation resulted in enhanced myogenic differentiation. Publication Status: Online-Only"
< "Q8K2F0-1","RefSeq","NP_001107045.1","27667451","Brd3 knockout significantly decreased the recruitment of acetylase CBP to IL6 gene promoter, and the acetylation level of histone3 within IL6 gene promoter was repressed."
< "Q8K2F0-1","RefSeq","NP_001107045.1","24248598","Data show that infection of macrophages with Listeria monocytogenes caused binding of the BET proteins Brd2, Brd3, and, most prominently, Brd4 to the Nos2 promoter."
< "Q8K2F0-1","RefSeq","NP_001107045.1","16008511","A conserved but uncharacterized gene encoding Brd3, which was down-regulated during endothelial differentiation, was identified."
< "Q8K2F0-1","RefSeq","NP_001107045.1","15128596","More strongly expressed in developing testis compared with ovary"
---
> "Q8BGL3-1","RefSeq","NP_780459.1","29685090","Findings suggested that substitutions of two amino acids, which might have occurred during the evolution of the mouse SULT2A8 gene, endowed mouse SULT2A8 the capacity to catalyze the 7-O-sulfation of bile acids"
> "Q8BGL3-1","RefSeq","NP_780459.1","28442498","A novel PPARalpha-dependent gene"
10015a13348,13349
> "Q9QYB5-1","RefSeq","NP_038786.2","22706708","C-terminal 38 amino acids of gamma-adducin interact with F-actins around the Golgi complex, to facilitate exit of POMC/ACTH vesicles."
> "Q9QYB5-1","RefSeq","NP_038786.2","19900187","These results strongly suggest coordinated expression and phosphorylation of alpha-, beta-, and gamma-adducins as key mechanism underlying synaptic plasticity, motor coordination performance and learning behaviors."
10017,10018c13351,13355
< "Q8R4V2-1","RefSeq","NP_001152848.1","27891578","Dusp15 is necessary for full activation of Erk 1/2 phosphorylation in Schwann cells."
< "Q8R4V2-1","RefSeq","NP_001152848.1","15138252","VHY is a new member of a subgroup of myristoylated VH1-like small dual specificity phosphatases"
---
> "Q9CQ44-1","RefSeq","NP_079740.1","25161209","Tmem218-/- mice develop progressive cystic kidney disease and retinal degeneration, a model for Senior-Loken syndrome"
> "P63034-1","RefSeq","NP_035311.1","26498519","The RLIP76/R-Ras/ARNO complex localizes to recycling endosomes."
> "P63034-1","RefSeq","NP_035311.1","25824033","Signaling through cytohesin-2 is required for myelination by Schwann cells, and cytohesin-2 is added to the list of molecules known to underlie PNS myelination"
> "P63034-1","RefSeq","NP_035311.1","25450674","Results together suggest that cytohesin 2 activates ARF6 in a PI3K dependent manner and then the active ARF6 causes phosphorylation of ERK1/2 during preadipocyte migration."
> "P63034-1","RefSeq","NP_035311.1","25450693","Results show that ARNO interaction with the RLIP76 N-terminus regulates cell spreading and motility via PI3K and Arf6, independent of RLIP76 control of Rac"
10021a13359
> "Q91YX5-1","RefSeq","NP_758470.1","20018982","LPGAT1, a newly identified MGAT enzyme, plays a significant role in hepatic triacylglycerol synthesis and secretion in db/db mice."
10022a13361,13362
> "P61215-1","RefSeq","NP_082572.1","28154140","CA10 directly binds in a cis configuration to a conserved membrane-proximal, extracellular sequence of alpha- and beta-neurexins. Erratum:[Proc Natl Acad Sci U S A. 2017 Apr 4;114(14 ):E2984. PMID: 28320946]"
> "P61215-1","RefSeq","NP_082572.1","12531530","Results describe the tissue distribution of carbonic anhydrase-related proteins VIII, X, and XI and their developmental expression in the murine embryonic brain."
10028,10031d13367
< "Q69ZP3-1","RefSeq","NP_001034598.1","25730884","PNKD KO mice, RIM1/2 protein levels are reduced and synaptic strength is impaired. Thus, PNKD is a novel synaptic protein with a regulatory role in neurotransmitter release"
< "Q69ZP3-1","RefSeq","NP_001034598.1","22214848","These findings support the hypothesis that the PNKD protein functions to modulate striatal neuro-transmitter release in response to stress and other precipitating factors."
< "Q69ZP3-1","RefSeq","NP_001034598.1","20040360","These findings suggest that silencing MR-1 protected mice myocardium against inflammatory injury induced by AngII by suppression of pro-inflammatory transcription factors NF-kappaB and AP-1 signaling pathway."
< "Q69ZP3-1","RefSeq","NP_001034598.1","15496428","Paroxysmal non-kinesigenic dyskinesia (PNKD) is characterized by spontaneous hyperkinetic attacks that are precipitated by alcohol, coffee, stress and fatigue."
10046a13383,13385
> "O08797-1","RefSeq","NP_033282.1","28024184","These findings add support for role for Sb9 cross-presentation, and indicate that high Sb9 expression is a novel marker of cross-presentation capable dendritic cells"
> "O08797-1","RefSeq","NP_033282.1","26670609","Data suggest that reactive oxygen species (ROS) generated within cytotoxic lymphocytes by receptor stimulation are required for lysosomal permeabilization and release of GzmB (granzyme B) into the cytosol and for inactivation of serpin B9."
> "O08797-1","RefSeq","NP_033282.1","15454490","SPI-CI is a novel immune escape molecule that acts in concert with SPI-6 to prevent cytotoxic lymphocyte-mediated killing of tumor cells."
10052a13392,13401
> "P51829-1","RefSeq","NP_031432.2","20505140","Adenylyl cyclase 7 controls the extent of immune responses toward bacterial infection and is required for optimal functions of B and T cells during adaptive immune responses. It regulates cyclic adenosine monophosphate (cAMP) synthesis in B and T cells."
> "P21183-1","RefSeq","NP_032396.1","25330943","SLy2 controls the antibody response to pneumococcal vaccine through an IL-5Ralpha-dependent mechanism in B-1 cells."
> "P21183-1","RefSeq","NP_032396.1","21770429","Deglycosylated variant Il5ralpha has the same ligand binding affinity and biological activity as fully glycosylated IL5Ralpha, thus demonstrating a unique role for Asn196 glycosylation in IL5Ralpha function."
> "P21183-1","RefSeq","NP_032396.1","19428566","We identified B-1 progenitors expressing low levels of IL-5 receptor alpha chain (IL-5Ralpha) and eosinophil progenitors expressing higher levels of IL-5Ralpha in the fetal liver"
> "P28574-1","RefSeq","NP_001139648.1","30403691","MAX associated with DNA methyltransferases (DNMTs) and the histone methyltransferase SETDB1 cooperatively control germ cell-related gene expression in embryonic stem cells. Publication Status: Online-Only"
> "P28574-1","RefSeq","NP_001139648.1","30126925","We also describe that B lymphocytes lacking Myc, Max, or both show upregulation of signaling pathways associated with the B-cell receptor. These data suggest that c-Myc/Max heterodimers are not essential for the initiation of a subset of important biological processes in B lymphocytes, but are required for fine-tuning the initial response after activation."
> "P28574-1","RefSeq","NP_001139648.1","28220481","Studies suggest that inducible MYC Associated Factor X (MAX) knockout embryonic stem cells (ESCs) provide an excellent platform for exploring the molecular mechanisms of meiosis initiation. Review article"
> "P28574-1","RefSeq","NP_001139648.1","27025988","MAX is a new regulator of meiotic onset. Publication Status: Online-Only"
> "Q8K0H7-1","RefSeq","NP_666089.1","25164149","Real-time PCR of mouse tissues confirmed mRNA expression of SLC45A2 in eyes and skin and of SLC45A3 primarily in the prostate, but also in other tissues, whereas SLC45A4 showed a predominantly ubiquitous expression."
> "Q8K0H7-1","RefSeq","NP_666089.1","22521588","Our data suggest that miR-32 and its downstream target SLC45A3 play important roles in myelin maintenance"
10056a13406,13409
> "P27808-1","RefSeq","NP_034924.3","30138037","Mgat1KO provides a model for investigating the relationship between systemic reductions in glycosylation and cardiac disease, showing that clinically relevant changes in cardiomyocyte hybrid/complex N-glycosylation are sufficient to cause DCM and early death"
> "P27808-1","RefSeq","NP_034924.3","29853530","MGAT1 activity may play a role in regulating basal adipocyte FFA retention"
> "P27808-1","RefSeq","NP_034924.3","29386567","MGAT1 is required to regulate ERK1/2 signaling during spermatogenesis, potentially via different mechanisms. Publication Status: Online-Only"
> "P27808-1","RefSeq","NP_034924.3","28347400","The MGAT1 interacts with DGAT2, which serves to synergistically increase the TAG biosynthesis and LD expansion, leading to enhancement of lipid accumulation in the liver and fat."
10058a13412,13415
> "Q69ZX6-1","RefSeq","NP_001152760.1","29728365","We characterized two factors, MORC2A and RESF1, of which RESF1 is a novel molecule in retroelement silencing. Although both factors are recruited to repress provirus, their roles in repression are different. MORC2A appears to function dependent on repressive epigenetic modifications, while RESF1 regulates repressive epigenetic modifications associated with SETDB1"
> "Q69ZX6-1","RefSeq","NP_001152760.1","24286864","These results demonstrate a cytosolic function of MORC2 in lipogenesis, adipogenic differentiation, and lipid homeostasis by regulating the activity of ACLY.[Morc2]"
> "Q923S9-1","RefSeq","NP_083770.2","22960262","Rabs may participate in inflammatory response in microglia during brain inflammation."
> "Q923S9-1","RefSeq","NP_083770.2","21308349","Rab30 and S100a8/S100a9 were indicated to play roles in the initiation of liver regeneration as well as possibly in the functional switch of the liver in the newborn stage."
10069,10070c13426,13427
< "Q3UPF5-1","RefSeq","NP_082697.1","23776219","S-farnesylation is crucial for targeting the long-isoform of ZAP to endolysosomes and enhancing the antiviral activity of this immune effector."
< "Q3UPF5-1","RefSeq","NP_082697.1","22951821","ZAP inhibits M2 expression and regulates the maintenance of MHV-68 latency"
---
> "Q8BJU2-1","RefSeq","NP_780623.1","28032533","Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation."
> "Q8BJU2-1","RefSeq","NP_780623.1","18799160","Tetraspanin CD9 has a role in determining vascular smooth muscle cell injury phenotypes"
10074a13432,13437
> "Q8CCG4-1","RefSeq","NP_082886.2","30692203","Dppa2 and Dppa4 directly regulate the 2C-like cell population and associated transcripts, including Dux and the Zscan4 cluster."
> "Q8CCG4-1","RefSeq","NP_082886.2","30146411","Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency"
> "Q8CCG4-1","RefSeq","NP_082886.2","29327467","Identifies EBP1 as a novel pluripotency cofactor and provides insight into potential mechanisms used by DPPA4 in regulating pluripotency through its association with EBP1"
> "Q8CCG4-1","RefSeq","NP_082886.2","18366076","Thsi study identifies DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays."
> "Q8CCG4-1","RefSeq","NP_082886.2","17855347","DPPA4 is a nuclear factor associated with active chromatin"
> "Q8CCG4-1","RefSeq","NP_082886.2","16990585","Study of expression and function of pluripotent markers such as Dppa2 and Dppa4 is likely to unveil new aspects of the regulation of pluripotency and germ line development in mammals."
10075a13439,13440
> "Q3UW26-1","RefSeq","NP_001288611.1","22539676","Both native BSPH1 and recombinant-BSPH1 were detected on the head and the midpiece region of sperm, although a stronger signal was detected on the midpiece region when sperm were incubated in a capacitating media. Publication Status: Online-Only"
> "Q3UW26-1","RefSeq","NP_001288611.1","17307309","Sperm-binding fibronectin type II-module proteins are genetically linked and functionally related."
10077a13443
> "Q80U57-1","RefSeq","NP_891559.1","26142343","Mouse RIM3 proteins carrying amino acid substitutions that correspond to mutations associated with autism (E176A and M259V) modify RIM3 interaction with VDCC beta-subunits"
10080a13447,13450
> "Q80U58-1","RefSeq","NP_109648.2","30642763","A PUM2-mediated layer of post-transcriptional regulation links altered Mff translation to mitochondrial dynamics and mitophagy, thereby mediating age-related mitochondrial dysfunctions."
> "Q80U58-1","RefSeq","NP_109648.2","29046322","These results argue for a role of Pum2 in epileptogenesis and the maintenance of epilepsy."
> "Q80U58-1","RefSeq","NP_109648.2","28794184","Major role of Pum1 and Pum2 in hippocampal neurogenesis and function"
> "P12660-1","RefSeq","NP_032816.1","27525924","A novel Pcp2 transcript is particular to mouse cerebellar Purkinje cells and retinal bipolar neurons. Publication Status: Online-Only"
10092a13463,13470
> "Q61827-1","RefSeq","NP_034887.1","26901059","Beta-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development Publication Status: Online-Only"
> "Q61827-1","RefSeq","NP_034887.1","25896808","These data identify Mafg and Mafk as new cataract-associated candidates and define their function in regulating largely non-crystallin genes linked to human cataract."
> "O08663-1","RefSeq","NP_062622.1","18828628","Discovery, identification, and characterization of candidate pharmacodynamic markers of Metap2 inhibition are reported."
> "O08663-1","RefSeq","NP_062622.1","18264137","MetAP2 plays an important role in tumor cell growth and may contribute to tumorigenesis"
> "O08663-1","RefSeq","NP_062622.1","17446530","Data suggest that methionine aminopeptidase 2 plays a role in the proliferation of fibroblasts and myofibroblasts in fibrotic lung diseases and may serve as a novel pharmacologic target in idiopathic pulmonary fibrosis."
> "O08663-1","RefSeq","NP_062622.1","16790550","Demonstrate an essential role for MetAP-2 in angiogenesis and indicate that MetAP-2 is responsible for the endothelial cell growth arrest induced by fumagillin and its derivatives"
> "O08663-1","RefSeq","NP_062622.1","15572037","The stability of p67 increases during myotube formation while inhibiting the phosphorylation of ERKs 1 and 2."
> "O08663-1","RefSeq","NP_062622.1","11994292","The functional role of S100A4 in regulating endothelial cell growth and tumor metastasis involves interaction with the N-terminal half of Methionine Aminopeptidase 2."
10113a13492,13496
> "Q5U4C1-1","RefSeq","NP_080357.4","25657005","Present the First low resolution solution structure of myostatin-free and myostatin-bound states of GASP-1 and GASP-2"
> "Q5U4C1-1","RefSeq","NP_080357.4","25277978","Gasp-1 overexpression resulted in increased myostatin expression."
> "Q5U4C1-1","RefSeq","NP_080357.4","24019467","GASP-1 and GASP-2 are important modulators of GDF-11 and MSTN activity in vivo."
> "Q5U4C1-1","RefSeq","NP_080357.4","23046573","Overexpression of Gasp1 led to an increase in muscle mass observed not before day 15 of postnatal life. Publication Status: Online-Only"
> "Q5U4C1-1","RefSeq","NP_080357.4","21091868","The pattern of behavioral deficits observed in GASP-1-deficient mice is coherent with current knowledge of the role of striatal G protein-coupled receptor(GPCR)s in acquisition/expression of skilled behavior and motivation."
10116a13500,13503
> "Q91XB0-1","RefSeq","NP_035767.4","29734329","Leu24-Pro25-Ser26 cluster of TREX1 served to cap the nonscissile 5'-end of the DNA for precise removal of the short 3'-overhang in L- and Y-structural DNA or to wedge into the double-stranded region for further digestion along the duplex Publication Status: Online-Only"
> "Q91XB0-1","RefSeq","NP_035767.4","28835460","Data do not support the concept of retroelement-derived cDNA as key triggers of systemic autoimmunity in Trex1-deficient humans and mice"
> "Q91XB0-1","RefSeq","NP_035767.4","28598415","Trex1 is an upstream regulator of radiation-driven anti-tumor immunity. Trex1 induction may guide the selection of radiation dose and fractionation in patients treated with immunotherapy. Publication Status: Online-Only"
> "Q91XB0-1","RefSeq","NP_035767.4","15254239","Trex1(-/-) mice exhibit a dramatically reduced survival and develop inflammatory myocarditis leading to progressive, often dilated, cardiomyopathy and circulatory failure"
10123a13511,13512
> "Q8VD75-1","RefSeq","NP_666113.2","30224518","Gdpd3 compensates for Hip1 loss. Publication Status: Online-Only"
> "Q8VD75-1","RefSeq","NP_666113.2","24659689","We show that M. tuberculosis impairs dendritic cell cytokine secretion, maturation, and antigen presentation through the cell envelope-associated serine hydrolase, Hip1."
10133a13523
> "Q9QZN4-1","RefSeq","NP_056612.1","12939278","Fbs2 is a novel member of F-box protein family that recognizes N-glycans and plays a role in ERAD"
10137a13528,13530
> "Q9CXX9-1","RefSeq","NP_077154.2","27286733","Notably, CUEDC2 promoted E3 ubiquitin ligases tripartite motif-containing 33 (TRIM33)-mediated the antioxidant enzyme, glutathione peroxidase 1 (GPX1) ubiquitination, and proteasome-dependent degradation. Publication Status: Online-Only"
> "Q9CXX9-1","RefSeq","NP_077154.2","26182901","These findings demonstrate that CUEDC2 plays an important role in protection from colonic inflammation, primarily by inhibiting the NF-kappaB and STAT3 signaling pathways and preventing excessive proliferation of the inflammatory epithelial cell."
> "Q9CXX9-1","RefSeq","NP_077154.2","24882011","CUEDC2 plays a crucial role in modulating macrophage function and is associated with both colitis and colon tumorigenesis."
10141a13535,13539
> "Q8BMQ8-1","RefSeq","NP_766603.1","20305638","Data identify SAND-1 (Mon1) and CCZ-1 (Ccz1) as critical and evolutionarily conserved components regulating the processing of ingested apoptotic cell corpses"
> "P59438-1","RefSeq","NP_001161336.1","27333462","Nonsense Mutation in HPS5 gene is associated with hypopigmentation in colitis mice."
> "P59438-1","RefSeq","NP_001161336.1","23672590","Effects of the ru2(d) allele on pheomelanin synthesis were investigated."
> "P59438-1","RefSeq","NP_001161336.1","23030338","These results suggest that the ru2(d) allele suppresses the differentiation of melanocytes through the inhibition of eumelanin synthesis, but stimulates pheomelanin synthesis in melanocytes."
> "P59438-1","RefSeq","NP_001161336.1","22035301","These results suggest that the ru2(d) allele inhibits melanocyte differentiation, and that its impaired differentiation is rescued by excess tyrosine."
10157a13556,13557
> "O55103-1","RefSeq","NP_932165.2","26538089","Taken together, these observations reveal that AnkB is required for Prx membrane anchoring and for maintenance of lens fiber cell hexagonal geometry, membrane skeleton organization, and biomechanics."
> "O55103-1","RefSeq","NP_932165.2","22764250","Cajal band appositions contain a dystroglycan complex that includes periaxin and dystrophin-related protein (Drp)2."
10160a13561,13563
> "O08537-1","RefSeq","NP_997590.1","30974833","Rhododendrin is cytoprotective against 6-hydroxydopamine (6-OHDA)-induced cell death, which is largely dependent on ERbeta activity and RNF146 expression. Publication Status: Online-Only"
> "O08537-1","RefSeq","NP_997590.1","30342056","Selective activation of ERbeta exerts a tissue-specific activity which promotes a beneficial effect on whole body metabolic response to obesity."
> "O08537-1","RefSeq","NP_997590.1","30459405","Estrogen receptor beta modulates miR-92a/DAB2IP signaling to promote bladder cancer cell growth and invasion. Publication Status: Online-Only"
10173a13577,13579
> "Q7TNC8-1","RefSeq","NP_906272.1","29057625","These results, which reveal neurodevelopmental roles for alpha2-GlyRs in the adult brain, may be clinically relevant, given that a mutation in GLAR2, as well as Adult hippocampal neurogenesis impairments."
> "Q7TNC8-1","RefSeq","NP_906272.1","28784756","Alpha2 and alpha3 GlyRs are present in various regions of the forebrain and that alpha3 GlyRs specifically participate in tonic inhibition in the striatum and prefrontal cortex."
> "Q7TNC8-1","RefSeq","NP_906272.1","26891984","Findings show that the loss of embryonic GlyRalpha2 ultimately impairs the formation of cortical circuits in the mature brain; results demonstrate a physiological role for alpha2 GlyRs during cortical network formation and homeostasis"
10177,10179d13582
< "P17095-2","RefSeq","NP_001020598.1","29867121","Findings highlight a novel FoxO1/HMGA1-mediated mechanism by which insulin may regulate gene expression and metabolism. Publication Status: Online-Only"
< "P17095-2","RefSeq","NP_001020598.1","29316384","HMGA1 expression was closely correlated with the clinical stage, histological grade, and tumor size in breast cancer patients and breast cancer progression in transgenic MMTV-PyMT mice"
< "P17095-2","RefSeq","NP_001020598.1","29101051","G9a has a novel role in modulating insulin signaling, at least in part, depending on its regulatory function on HMGA1"
10187,10190c13590
< "Q6PHZ2-1","RefSeq","NP_001020609.1","29992531","In summary, CaMKIIdelta and CaMKIIgamma are novel ischemia/reperfusion-induced genes that promote neuronal survival during ischemic injury. The upregulation of these CaMKII kinases led to activation of the NF-kappaB signaling pathway, which protects neurons from ischemic damage."
< "Q6PHZ2-1","RefSeq","NP_001020609.1","30571348","Activation of CaMKIIdelta in response to pressure overload triggers inflammatory gene expression and activation of the NOD-like receptor pyrin domain-containing protein 3 inflammasome in cardiomyocytes. These responses provide signals for macrophage recruitment, fibrosis, and myocardial dysfunction in the heart."
< "Q6PHZ2-1","RefSeq","NP_001020609.1","29360953","JNK2 activation up-regulates CaMKIIdelta expression in the aged atrium and may promote the occurrence of cardiac arrhythmias."
< "Q6PHZ2-1","RefSeq","NP_001020609.1","28383548","Surgical-induced Osteoarthritis mice treated with a miR-146a inhibitor significantly alleviated the destruction of articular cartilage via targeting Camk2d and Ppp3r2. Publication Status: Online-Only"
---
> "P55097-1","RefSeq","NP_031828.2","29781506","Ctsk(-/-) mice had fewer physis-derived chondroclasts than WT when OA was present..Our data provide insight into the cellular mechanisms by which Cathepsin K (CatK) deletion delays Osteoarthritis (OA) progression in mice."
10201a13602,13608
> "Q80W68-1","RefSeq","NP_570937.2","29717104","KIRREL was overexpressed in gastric cancer. Publication Status: Online-Only"
> "Q80W68-1","RefSeq","NP_570937.2","12538735","Analysis of five promoter-reporter gene constructs showed that regulatory elements driving expression encoded by exon 1A in kidney and brain are localized in region between -4 kb and 2.1 kb."
> "A2A9A2-1","RefSeq","NP_758500.2","30143575","Study suggests that DMRT3/5 function with EMX2 in positioning the pallial-subpallial boundary by antagonizing the ventral homeobox transcription factor GSX2."
> "A2A9A2-1","RefSeq","NP_758500.2","28031177","Finely tuned levels of DMRT5, together with DMRT3, regulate patterning of the cerebral cortex."
> "A2A9A2-1","RefSeq","NP_758500.2","29025924","Dmrt5 is neurogenic, and reciprocally regulated by Lhx2; loss of either factor promotes gliogenesis."
> "A2A9A2-1","RefSeq","NP_758500.2","28655839","There is a link between Dmrta2 modulation of Hes1 expression and the maintenance of neural progenitor cells during cortical development"
> "A2A9A2-1","RefSeq","NP_758500.2","21576465","Dmrt5 is an important player in ventral mesencephalic neural fate specification"
10204a13612,13616
> "Q5SNZ0-1","RefSeq","NP_789811.2","28375676","Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut"
> "Q5SNZ0-1","RefSeq","NP_789811.2","27666957","This study aimed to prove the participation of mTORC2/Akt in F-actin assembling in early-stage cleavage of mouse fertilized eggs via the function of Girdin."
> "Q5SNZ0-1","RefSeq","NP_789811.2","18316593","Girdin has an important role in tumor progression with aberrant activation of the Akt signaling pathway"
> "Q5SNZ0-1","RefSeq","NP_789811.2","18264090","The Akt/Girdin signalling pathway is essential in VEGF-mediated postneonatal angiogenesis"
> "Q5SNZ0-1","RefSeq","NP_789811.2","15882442","HkRP1 (A430106J12Rik) is involved in the process of tubulation of sorting nexin-1 positive membranes from early endosome subdomains."
10210a13623,13630
> "O35671-1","RefSeq","NP_032429.1","28049720","ICAP-1 monoubiquitylation helps in switching from ROCK2-mediated to MRCKalpha-mediated cell contractility. Erratum:[J Cell Sci. 2017 Mar 15;130(6):1195. PMID: 28298614]"
> "O35671-1","RefSeq","NP_032429.1","23918940","The CCM1 loss resulted in ICAP-1 destabilization, which increased beta1 integrin activation and led to increased RhoA-dependent contractility."
> "O35671-1","RefSeq","NP_032429.1","23720740","Data show that phosphorylation of ICAP-1alpha by CaMKII controls beta1 integrin activation and cell adhesion."
> "O35671-1","RefSeq","NP_032429.1","21768292","The ICAP-1 works in concert with kindlin-2 to control the dynamics of beta1 integrin-containing fibrillar adhesions and, thereby, regulates fibronectin deposition and osteoblast mineralization. Erratum:[J Cell Biol. 2013 May 13;201(4):643]"
> "O35671-1","RefSeq","NP_032429.1","20616313","Identify ICAP1 as a novel regulator to prevent excessive sprouting angiogenesis."
> "O35671-1","RefSeq","NP_032429.1","17654484","ICAP-1 regulates beta1 integrin-dependent cell migration by affecting the pattern of focal adhesion formation."
> "O35671-1","RefSeq","NP_032429.1","17567669","ICAP-1 promotes differentiation of osteoprogenitors by supporting their condensation through modulating the integrin high affinity state."
> "O35671-1","RefSeq","NP_032429.1","16741948","Integrin cytoplasmic domain-associated protein-1 (ICAP-1) binds ROCK to beta1 integrin at the cell membrane (ICAP-1)"
10211a13632,13634
> "Q64143-1","RefSeq","NP_853616.1","29350678","PIK3R3 regulates the expression of PPAR-alpha.The activation of PIK3R3 decreased hepatosteatosis.The novel PIK3R3-HNF4alpha-PPAR-alpha signaling axis plays a significant role in hepatic lipid metabolism. Publication Status: Online-Only"
> "Q64143-1","RefSeq","NP_853616.1","27322022","These data support an important role for the p55gamma subunit of PI3K in ALK-induced cell migration during brain development"
> "Q64143-1","RefSeq","NP_853616.1","23354733","P55PIK-PI3K stimulates angiogenesis in colorectal cancer cell by activating NF-kappaB pathway."
10215a13639,13646
> "Q91WT8-1","RefSeq","NP_848541.2","30309881","A1CF and RBM47 each function independently, yet interact in a tissue-specific manner, to regulate the activity and site selection of APOBEC1 dependent C-to-U RNA editing."
> "Q91WT8-1","RefSeq","NP_848541.2","26789794","Study demonstrated that Rbm47 function is required in the embryo proper, and not the visceral endoderm, for viability and growth."
> "Q91WT8-1","RefSeq","NP_848541.2","24916387","RBM47 and APOBEC1 constitute the basic machinery for C to U RNA editing."
> "Q91WT8-1","RefSeq","NP_848541.2","23649762","RNA-binding protein Rbm47 binds to Nanog in mouse embryonic stem cells."
> "Q9D6X6-1","RefSeq","NP_083890.2","29016706","Suggest a pivotal role for miR-532-prss23 axis in regulating cardiac endothelial cell function after myocardial infarction."
> "Q9D6X6-1","RefSeq","NP_083890.2","23451081","The study demonstrates the distinct expression of Prss23 and Prss35 in the periimplantation uterus and the dispensable role of Prss35 in fertility and embryo development."
> "Q9D6X6-1","RefSeq","NP_083890.2","18566130","HtrA1 and PRSS35 may be involved in ovulation and corpus luteum formation and regression, and that PRSS23 may play a role in follicular atresia"
> "Q9D6X6-1","RefSeq","NP_083890.2","16870946","Prss23 mRNA levels decreased transiently after ovulation induction and again in the postovulatory period"
10222,10223d13652
< "Q8CAE2-1","RefSeq","NP_001072114.1","29703750","Methylation substrates in mouse spermatogonial stem cells and the substrate-recognition mechanism of mammalian Hen1"
< "Q8CAE2-1","RefSeq","NP_001072114.1","26496356","DNA damage and a catastrophic deregulation of the haploid germ cell gene expression. Collectively these results define a critical role for HENMT1 and piRNAs in the maintenance of TE repression in adult germ cells and setting the spermatogenic program. Erratum:[PLoS Genet. 2015 Dec;11(12):e1005782. PMID: 26714033] Publication Status: Online-Only"
10227,10232c13656,13661
< "Q2EG98-1","RefSeq","NP_001034789.2","21185261","These results demonstrate that Asp(523) in PKD2L1 is a key determinant of Ca(2+) permeation into the PKD1L3/PKD2L1 complex and that PKD2L1 contributes to forming the pore of the PKD1L3/PKD2L1 channel."
< "Q2EG98-1","RefSeq","NP_001034789.2","19464260","PKD1L3-PKD2L1 channel activation by acetic acid was pH-dependent and occurred when the ambient pH was <3.1."
< "Q2EG98-1","RefSeq","NP_001034789.2","18535624","The off-response property of PKD1L3-PKD2L1 channels might explain the physiological phenomena occurring during sour taste sensation."
< "Q2EG98-1","RefSeq","NP_001034789.2","16891422","These results suggest that PKD1L3 and PKD2L1 heteromers may function as sour taste receptors."
< "Q2EG98-1","RefSeq","NP_001034789.2","16805797","Pkd1l3 and Pkd2l1 are co-expressed in a select subset of taste receptor cells and therefore may, like other PKD channels, function as a heteromer"
< "Q2EG98-1","RefSeq","NP_001034789.2","12782129","Genes are mapped to chromosomes and gene structures are characterized; protein structure is predicted and contains strong ion channel signature motifs that suggest their possible function as components of cation channel pores Erratum:[Genomics. 2003 Oct;82(4):498-500]"
---
> "Q9ES90-1","RefSeq","NP_071715.3","29414686","Kynurenic acid increases energy utilization by activating G protein-coupled receptor Gpr35, which stimulates lipid metabolism, thermogenic, and anti-inflammatory gene expression in adipose tissue."
> "Q9ES90-1","RefSeq","NP_071715.3","28648739","GPR35 signaling promotes mucosal repair by inducing fibronectin and integrin alpha5 expression, coupling to Gi protein, and activating ERK1/2 in colonic epithelial cells. These findings define GPR35 as a candidate therapeutic target in inflammatory bowel disease."
> "Q9ES90-1","RefSeq","NP_071715.3","24095869","Cardiac expression of GPR35 is regulated by hypoxia through activation of HIF-1."
> "Q9ES90-1","RefSeq","NP_071715.3","24312407","GPR35 activation may contribute to KYNA effects on the previously reported decrease of brain extracellular glutamate levels and reduction of excitatory transmission Publication Status: Online-Only"
> "Q3UJB9-1","RefSeq","NP_853625.1","16314453","Ge-1, the human ortholog of mouse Edc4, was shown to localize to mRNA processing bodies (P-body)in a human cell line. The C-terminal region is required for this localization."
> "Q3UJB9-1","RefSeq","NP_853625.1","7520377","The human Ge-1 gene (also known as Hedls and Edc4)is an ortholog of mouse Edc4. The gene was identified by screening a cDNA expression library using serum from a patient with Sjogren's syndrome."
10240a13670,13672
> "Q9WTM3-1","RefSeq","NP_035481.1","28881413","Down-regulation of SEMA6C led to massive primordial follicle activation."
> "Q8K0V4-1","RefSeq","NP_666288.1","29438013","Data indicate that autophagy-related protein 7 (Atg7) promotes cardiac dysfunction of CCR4-NOT complex component Cnot3 knockout (Cnot3 mKO) mice independently of the canonical autophagy pathway. Publication Status: Online-Only"
> "Q8K0V4-1","RefSeq","NP_666288.1","28032897","Cnot3(ad-/-) mice exhibit lipodystrophy."
10245,10247d13676
< "Q80U72-1","RefSeq","NP_001297472.1","30083817","Scribdeficient hematopoietic stem cells reveal impaired migratory capacity."
< "Q80U72-1","RefSeq","NP_001297472.1","12499390","Scrb1, encodes a member of the LAP protein family related to Drosophila scribble.Disruption of scribble (Scrb1) gene causes severe neural tube defects in the circletail mouse"
< "Q80U72-1","RefSeq","NP_001297472.1","12112872","Heterozygotes are incompletely penetrant for a circled-tail phenotype, while homozygotes die at birth of a severe neural tube defect."
10251a13681,13686
> "Q8BI41-1","RefSeq","NP_775596.1","18448564","Synb is co-expressed with Cebpa and Gcm1 in basal cells in contact with the allantois."
> "Q8BI41-1","RefSeq","NP_775596.1","18077339","Findings show that in both humans and mice, one of the two syncytins (human syncytin-2 and mouse syncytin-B) is immunosuppressive and, rather unexpectedly, the other (human syncytin-1 and mouse syncytin-A) is not"
> "Q8BI41-1","RefSeq","NP_775596.1","15644441","Critical role of syncytin-A and -B in syncytiotrophoblast formation, a situation where two pairs of endogenous retroviruses, independently acquired by primate and rodent lineages, were selected for a convergent physiological role. (syncytin-A, syncytin-B)"
> "P06801-1","RefSeq","NP_032641.2","28202838","Data suggest that Ad4BP plays role in regulation of intracellular NADPH concentration via transcription of Me1 and Mthfd2 genes in adrenocortical cells. (Ad4BP = nuclear receptor subfamily 5 group A member 1; Me1 = malic enzyme 1; Mthfd2 = bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase)"
> "P06801-1","RefSeq","NP_032641.2","26999781","This study showed that (2)H-labeled tracers enable dissection of NADPH production routes across cell types and environmental conditions."
> "P06801-1","RefSeq","NP_032641.2","26173780","ME1 expression was found to be mutant-KRAS-associated in an NSCLC mouse model. Publication Status: Online-Only"
10254a13690,13695
> "Q3T9X0-1","RefSeq","NP_001012363.2","30105595","SLC2A9 regulates urate reabsorption in the mouse kidney."
> "Q3T9X0-1","RefSeq","NP_001012363.2","30336599","Its anti-hyperuricemic mechanisms may be ascribed to its inhibition of XOD and its up-regulation of organic anion transporter 1 (OAT1) and down-regulation of glucose transporter 9 (GLUT9). Publication Status: Online-Only"
> "Q3T9X0-1","RefSeq","NP_001012363.2","25100214","Intestinal uric acid transporter SLC2A9 has a role in early-onset metabolic syndrome in a mouse model Publication Status: Online-Only"
> "Q3T9X0-1","RefSeq","NP_001012363.2","17913964","Glucose uptake via GLUT9a and GLUT9b likely affects normal spermatogenesis, steroidogenesis, and sperm function in the mouse."
> "Q3T9X0-1","RefSeq","NP_001012363.2","16293642","MGLUT9 protein expression was significantly increased in the kidney and liver from streptozotocin-induced diabetic mice compared with nondiabetic animals"
> "Q3T9X0-1","RefSeq","NP_001012363.2","14657010","Blocking GLUT9 expression during preimplantation development had no effect on glucose transport or apoptosis but transfer of these embryos resulted in increased pregnancy loss, suggesting that GLUT9 is critical for early preimplantation development."
10263a13705,13709
> "P12388-1","RefSeq","NP_035241.1","30093305","The observed reduction of the infarct volume was comparable to the protection obtained by intracerebroventricular injection of recombinant Activin A or SerpinB2 or by stereotactic delivery 3 weeks prior to the injury of a recombinant adeno-associated virus containing an expression cassette for the potent neuroprotective transcription factor Npas4"
> "P12388-1","RefSeq","NP_035241.1","28346421","This study establishes a novel role for SerpinB2 in the stromal compartment in pancreatic ductal adenocarcinoma invasion through regulation of stromal remodelling"
> "P12388-1","RefSeq","NP_035241.1","27109612","Data suggest that the function of keratinocyte SerpinB2 is protection of the stratum corneum from proteolysis via inhibition of urokinase, thereby maintaining the integrity and barrier function of the stratum corneum, particularly during times of skin inflammation"
> "P12388-1","RefSeq","NP_035241.1","26083412","SerpinB2 plays an important role in proteostas Publication Status: Online-Only"
> "P12388-1","RefSeq","NP_035241.1","25489104","SerpinB2 has previously been implicated as a mediator of DMBA/TPA-induced skin carcinogenesis"
10265a13712,13714
> "Q06507-1","RefSeq","NP_033846.2","30452920","In mice, ATF4 deficiency reduces glutamine uptake by intestinal epithelial cells and expression of antimicrobial peptides by decreasing transcription of Slc1a5."
> "Q06507-1","RefSeq","NP_033846.2","30431065","MEG3 promoted hepatic insulin resistance by serving as a competitive endogenous RNA of miR214 to facilitate ATF4 expression."
> "Q06507-1","RefSeq","NP_033846.2","15277680","Delayed reinitiation allows for ribosomes to scan through the inhibitory uORF2 and instead reinitiate at the ATF4-coding region."
10267a13717,13724
> "Q9R0L1-1","RefSeq","NP_036069.1","30316871","During lens development, phosphorylation of HSF4/S299 is downregulated in P3 lens and upregulated in P7 and P14 lens. However, in 2 months old lens, both phosphorylation of HSF4/S299 and total HSF4 protein are decreased."
> "Q9R0L1-1","RefSeq","NP_036069.1","27586257","A novel molecular mechanism of HSF4 in regulating lens epithelial cell homeostasis"
> "Q9R0L1-1","RefSeq","NP_036069.1","15483628","Data reveal the lens-specific role of heat shock transcription factor 4 (HSF4), and indicate that HSF1 and HSF4 are involved in regulating expression of growth factor genes."
> "Q9JJU9-1","RefSeq","NP_067327.1","30646012","The current study shows for the first time that two highly expressed lens crystallin genes, Cryba4 and Crybb1, can be simultaneously transcribed from adjacent bidirectional promoters and do not show nuclear accumulation."
> "P56399-1","RefSeq","NP_038728.1","30340616","USP5 mediated dysregulation of Cav3.2 channel activity does not exhibit sex differences, and potential therapeutics targeting this interaction should be effective in both male and female subjects. Publication Status: Online-Only"
> "P56399-1","RefSeq","NP_038728.1","28741432","Identify interleukin-1 beta as an upstream trigger for the upregulation of interactions between USP5 and Cav3.2 channels in the pain pathway"
> "P56399-1","RefSeq","NP_038728.1","27974205","Sensitization was relieved by pharmacological block of TRPV1 afferents, but not of myelinated neurons. In spinal cord slice recordings, we could optogenetically trigger an activity-dependent potentiation of presynaptic neurotransmission in the spinal dorsal horn that relied on Cav3.2 channel activity. This neuronal-activity-induced USP5 upregulation may underlie a protective, transient sensitization of the pain pathway. Erratum:[Cell Rep. 2017 Feb 28;18(9):2289-2290. PMID: 28249172]"
> "P56399-1","RefSeq","NP_038728.1","25889575","Suramin and Cav3.2/USP5 Tat-disruptor peptides were also tested in models of diabetic neuropathy and visceral pain, and provided remarkable protection Publication Status: Online-Only"
10270c13727,13730
< "Q9QUK0-1","RefSeq","NP_058608.1","14605869","Cdkl2 functions mainly in mature neurons and that mechanisms governing regulation of this gene expression in mice are distinct from those of immediate-early genes."
---
> "Q8VEA6-1","RefSeq","NP_598470.3","14660436","CHL2 expression is restricted to chondrocytes of various developing joint cartilage surfaces and connective tissues in reproductive organs."
> "Q03391-1","RefSeq","NP_032198.2","29651654","GluN2D co-localizes in the thalamus with GluNC and is predominantly expressed in interneurons."
> "Q03391-1","RefSeq","NP_032198.2","27480795","The GluN2D subunit of the NMDA receptor appears to be important for the recognition of individuals and development of normal emotionality in mice. 5-HT2C receptor antagonism may be a therapeutic target for treating social stress-induced anhedonia."
> "Q03391-1","RefSeq","NP_032198.2","27625038","These data provide evidence that interneurons contain synaptic NMDARs possessing a GluN2D subunit, which can influence interneuron function and signal processing."
10282a13743,13746
> "Q9ESF1-1","RefSeq","NP_114081.2","29111973","Otoferlin thus functions as a Ca(2+) sensor, setting the rates of primed vesicle fusion with the presynaptic plasma membrane and synaptic vesicle pool replenishment in the inner hair cell active zone. Publication Status: Online-Only"
> "Q9ESF1-1","RefSeq","NP_114081.2","17055430","Otoferlin is essential for a late step of synaptic vesicle exocytosis and may act as the major Ca(2+) sensor triggering membrane fusion at the auditory inner hair cell ribbon synapse."
> "Q80SY4-1","RefSeq","NP_659109.2","16061358","A targeted mutation of Mib1 in mice results in embryonic lethality;MIB1 activity is required for S3 cleavage of the Notch1 receptor."
> "Q80SY4-1","RefSeq","NP_659109.2","16000382","Mice lacking Mib1 die prior to embryonic day 11.5, with pan-Notch defects in somitogenesis, neurogenesis, vasculogenesis and cardiogenesis."
10284,10285d13747
< "Q06219-1","RefSeq","NP_001132981.1","30267803","The pathogenesis of cerebral ischemia-reperfusion injury is associated with Nurr1 upregulation followed by augmented mitochondrial fission via an abnormal YAP-INF2 pathways"
< "Q06219-1","RefSeq","NP_001132981.1","30111648","NR4A1/Nur77 and NR4A2/Nurr1 dynamically regulated inflammatory gene expression in glia by modulating the transcriptional activity of NF-kappaB."
10288a13751,13760
> "Q1XH17-1","RefSeq","NP_001073401.1","30614598","MG53 overexpression could promote the expression of Ambra1 in C2C12 cells and restore mitochondrial autophagy."
> "Q1XH17-1","RefSeq","NP_001073401.1","29884820","MID-00935 disrupted the molecular interaction of MG53 and IRS-1, abrogated MG53-induced IRS-1 ubiquitination and degradation and improved insulin signaling in C2C12 myotubes. Publication Status: Online-Only"
> "Q1XH17-1","RefSeq","NP_001073401.1","29268030","TRIM72 regulates phagocytosis in alveolar macrophages."
> "Q1XH17-1","RefSeq","NP_001073401.1","28822805","MG53 is essential to preserve T-tubule integrity and thereby Ca(2+) handling properties and cardiac function under pathological cardiac stress."
> "Q1XH17-1","RefSeq","NP_001073401.1","27841305","Results show that MG53 binds to Orai1 via its PRY-SPRY region and co-localizes with Orai1 in the plasma membrane in skeletal muscle which enhances extracellular Ca2+ entry via Orai1 by store-operated Ca(2+) entry mechanism. Publication Status: Online-Only"
> "Q1XH17-1","RefSeq","NP_001073401.1","20139895","TRIM72 is a novel antagonist of IRS-1, and is essential as a negative regulator of IGF-induced muscle differentiation."
> "Q1XH17-1","RefSeq","NP_001073401.1","19380584","Molecular complex formed by MG53, dysferlin, and Cav3 is essential for repair of muscle membrane damage in muscular dystrophy."
> "Q1XH17-1","RefSeq","NP_001073401.1","19029292","Co-expression studies indicated that MG53 activity is regulated by a functional interaction with caveolin-3"
> "Q1XH17-1","RefSeq","NP_001073401.1","19202355","Suggest MG53 is involved in a constitutive cycle of cell-surface proteins between the plasma membrane and endosome-like vesicles in striated muscle, and also that the vesicular dynamics are essential for the quality control of KV2.1 in cardiomyocytes."
> "Q1XH17-1","RefSeq","NP_001073401.1","19043407","Intracellular vesicle translocation and Ca(2+)-dependent membrane fusion are distinct steps involved in the repair of membrane damage; MG53 may initiate the assembly of the membrane repair machinery in an oxidation-dependent manner."
10291,10296c13763,13770
< "O88838-1","RefSeq","NP_001292979.1","28270450","Collectively, Ssb1 and Ssb2 control crucial aspects of Hematopoietic stem and progenitor cells function, including proliferation and survival in vivo by resolving replicative stress to maintain genomic stability."
< "O88838-1","RefSeq","NP_001292979.1","20561531","Structural changes limit high-affinity interactions for SPSB2 to aspartate-containing sequences"
< "O88838-1","RefSeq","NP_001292979.1","20603330","The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation."
< "O88838-1","RefSeq","NP_001292979.1","17088318","Backbone dynamics of SSB-2 by means of Modelfree analysis."
< "O88838-1","RefSeq","NP_001292979.1","16369487","Determined the first SPRY-domain structure of SSB-2 that adopts a novel fold and contains conserved structural determinants for binding to prostate apoptosis response protein-4 (PAR-4)."
< "O88838-1","RefSeq","NP_001292979.1","15964819","Genetic deletion of SOCS Box Protein 2 results in a very mild thrombocytopenia."
---
> "Q8C015-1","RefSeq","NP_766446.2","23710594","PAK-7 p21-activated kinase 5 knockout mice are more sensitive to the stimulant effects of amphetamine"
> "Q8C015-1","RefSeq","NP_766446.2","23593460","Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice Publication Status: Online-Only"
> "Q8C015-1","RefSeq","NP_766446.2","22732262","PAK 5 is involved in formalin-induced inflammatory nociception through regulation of MAPK-induced c-Fos-activation and formalin-specific transient receptor potential-channels."
> "Q8C015-1","RefSeq","NP_766446.2","15615695","PAK5 may provide a molecular rationale for late-stage complications in diabetes."
> "Q8CC88-1","RefSeq","NP_776119.2","29660410","Analyses indicate that the mouse Vwa8 gene produces two transcripts; the full-length Vwa8a is highly expressed relative to the truncated Vwa8b transcript across all developmental time points and tissues analyzed.These data establish the development timeline and expression profile for both Vwa8a and Vwa8b."
> "Q8CC88-1","RefSeq","NP_776119.2","28414126","The VWA8 protein was targeted exclusively to mitochondria in mouse AML12 liver cells, and this was prevented by deletion of the targeting sequence."
> "Q9JL16-1","RefSeq","NP_065608.2","30232164","ISG20 upregulated IFIT1 genes and inhibited translation of the alphavirus genome. Furthermore, IFIT1-sensitive alphavirus replication was increased in Isg20(-/-) mice compared to the replication of wild-type viruses but not in cells ectopically expressing ISG20. Publication Status: Online-Only"
> "Q9JL16-1","RefSeq","NP_065608.2","19321657","Suggest that the recruitment of peripheral CXCR4-expressing ITGA2(+)ISG20(+) NK cells into pregnant uteri may be important in the regulation of feto-maternal tolerance."
10299a13774
> "P17156-1","RefSeq","NP_032327.2","27932549","Proteolytic degradation of Hspa2 occurs in response to oxidative stress mediated by 4-hydroxynonenal in male germ cells of the mouse."
10301a13777,13781
> "Q62187-1","RefSeq","NP_033468.2","29305861","Together with results showing involvement of TTF-1 in the TNF-alpha-induced increase in interleukin 1 beta and monocyte chemotactic protein 1 production, this study suggests that TTF-1 plays an important role in the mouse hypothalamus TNF-alpha-induced inflammatory response for regulating HO-1 gene expression."
> "Q62187-1","RefSeq","NP_033468.2","27173733","This study shows that in a mouse model of thyrocyte hyperplasia, proliferating thyrocytes were thyroid transcription factor (TTF1)-positive Erratum:[Cell Immunol. 2016 Dec;310:214. PMID: 27613603]"
> "Q62187-1","RefSeq","NP_033468.2","24970044","TTF-1 is expressed in lung during different stages of development. Publication Status: Online-Only"
> "Q3UY90-1","RefSeq","NP_808411.1","30188967","In mouse embryo fibroblasts (MEFs) obtained from cavin-1-/- or caveolin-1-/- mice, Fam198a precursor was retained in ER and no mature Fam198a could be formed in these cells."
> "Q9JJV1-1","RefSeq","NP_067516.1","21212184","These findings demonstrate the first mutation in the Cryba2 gene Publication Status: Online-Only"
10320a13801,13806
> "O89053-1","RefSeq","NP_034028.1","30611611","This study shows that disruption of Coronin 1 signaling in T cells promotes allograft tolerance while maintaining anti-pathogen immunity"
> "O89053-1","RefSeq","NP_034028.1","30453345","Coro1A has a role in platelet biology with impact on spreading, aggregation and thrombosis"
> "O89053-1","RefSeq","NP_034028.1","30131335","PtpA from Staphylococcus aureus contributes to virulence and interacts with coronin-1A during infection."
> "O89053-1","RefSeq","NP_034028.1","28821585","Results suggest the existence of a hitherto unrecognized coronin 1-dependent decision switch early during life that is responsible for peripheral naive T cell survival and homeostasis."
> "O89053-1","RefSeq","NP_034028.1","28615221","Coro1A represents an important novel player in integrin biology, with key functions in polymorphonuclear neutrophils trafficking during innate immunity."
> "P70278-1","RefSeq","NP_033318.1","30106128","It suggested that Stra8 may directly or indirectly inhibit caspases through the AKT signaling pathway and ultimately exert an antiapoptotic effect in the male reproductive system."
10327a13814,13815
> "P01216-1","RefSeq","NP_034019.1","29054929","Data suggest that expression of Rps6ka5 in gonadotroph cell line is up-regulated by GnRH signaling and is required for Cga expression; GnRH-activates Rps6ka5 targets at the first nucleosome just downstream from the transcriptional start site. (Rps6ka5= mitogen and stress-activated protein kinase 1; GnRH = gonadotropin-releasing hormone; Cga = gonadotropin alpha subunit)"
> "P01216-1","RefSeq","NP_034019.1","27452800","TSH improves insulin sensitivity in skeletal muscle by increasing Irs1 gene expression."
10350a13839,13840
> "Q9WU42-1","RefSeq","NP_001240834.1","30664766","Mice with NCOR1 and NORC2 depletion specifically in GABAergic neurons (NS-V mice) had memory deficits and had reduced GABAA receptor subunit alpha2 (GABRA2) expression in lateral hypothalamus GABAergic (LH(GABA)) neurons. Erratum:[Nat Neurosci. 2019 Sep;22(9):1533. PMID: 31222187]"
> "Q9WU42-1","RefSeq","NP_001240834.1","29531310","The NCoR/SMRT-HDAC3 co-repressor complex interacts with all of OSKM to create an epigenetic barrier to reprogramming, but c-MYC is the major partner. Erratum:[Nat Cell Biol. 2018 Oct;20(10):1227. PMID: 29907862]"
10357a13848,13851
> "P35343-1","RefSeq","NP_034039.1","30517976","CXCR2 knockout (KO) mice have thinner skin compared to wild-type mice due to a thinner subcutaneous adipose layer, as a result of fewer and smaller individual adipocytes."
> "P35343-1","RefSeq","NP_034039.1","30630119","Loss of CCL5 could enhance CXCL1 expression in hepatocytes and activate CXCL1-CXCR2 axis in neutrophils to augment their hepatic infiltration"
> "Q63739-1","RefSeq","NP_035330.1","27899452","Data shed new light on the structural basis underlying the interaction between PRL phosphatases and CNNM transporters and provides a hypothesis about the molecular mechanism by which PRL-1, upon binding to CNNM2, might increase the intracellular concentration of Mg(2+) thereby contributing to tumor progression and metastasis."
> "Q63739-1","RefSeq","NP_035330.1","25377314","Prl-1 is required for proper timing of liver regeneration after partial hepatectomy"
10358a13853,13862
> "Q3TUL7-1","RefSeq","NP_932122.2","29907856","Disruption of Dcaf17 caused asymmetric acrosome capping, impaired nuclear compaction and abnormal round spermatid to elongated spermatid transition. For the first time, these data indicate that DCAF17 is essential for spermiogenesis. Erratum:[Sci Rep. 2018 Aug 1;8(1):11779. PMID: 30068992] Publication Status: Online-Only"
> "Q3TUL7-1","RefSeq","NP_932122.2","29178422","A mouse model mimicking loss of function in exon 2 of Dcaf17 was generated using CRISPR/Cas9 and showed female subfertility and male infertility."
> "Q8CIZ9-1","RefSeq","NP_757340.1","30700829","Was increased by NOX1/ROS signaling."
> "Q8CIZ9-1","RefSeq","NP_757340.1","30445007","In mice given injections of a liver carcinogen (DEN), expression of NOX1 by macrophages promotes hepatic tumorigenesis by inducing the production of inflammatory cytokines."
> "Q8CIZ9-1","RefSeq","NP_757340.1","30154263","Nox1(-/-) and Nox2(-/-) mice showed higher susceptibility to avirulent type III Toxoplasma gondii infection than wild-type mice Publication Status: Online-Only"
> "Q8CIZ9-1","RefSeq","NP_757340.1","16724959","Expression of the Nox1 gene is regulated by alternative promoters and that the novel c-type transcript is induced under phenotypic modulation of vascular smooth muscle cells"
> "Q8CIZ9-1","RefSeq","NP_757340.1","16386251","Results establish a role for NOX1 in blood pressure regulation and vascular angiotensin II response."
> "Q8CIZ9-1","RefSeq","NP_757340.1","16246966","A pivotal role for ROSs derived from Nox1/NADPH oxidase was suggested in the pressor response to angiotensin II by reducing the bioavailability of nitric oxide."
> "Q8CIZ9-1","RefSeq","NP_757340.1","14597699","NADPH oxidase-dependent ROS production controls ERK1/2 activation in neuroprogenitor, hypothalamic, and lymphoid cells"
> "Q8CIZ9-1","RefSeq","NP_757340.1","12817011","In situ hybridization in mouse colon reveals high Nox1 expression within the lower two-thirds of colon crypts, where epithelial cells undergo proliferation and differentiation."
10363a13868,13874
> "Q8R0N9-1","RefSeq","NP_780369.1","23687301","In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes."
> "P70677-1","RefSeq","NP_033940.1","21515572","Mutation in the planar cell polarity gene, Scrib, and a mutation in caspase-3 gene have the most profound effect in controlling neural development."
> "P70677-1","RefSeq","NP_033940.1","21116635","A point mutation in Casp3 alters the catalytic cysteine residue and causes sensorineural hearing loss."
> "P70677-1","RefSeq","NP_033940.1","20510932","Hippocampal slices from caspase-3 knockout mice lose specifically their ability to undergo NMDA receptor-dependent long-term depression; these findings reveal a critical role of the mitochondrial pathway of caspase activation in synaptic depression."
> "P70677-1","RefSeq","NP_033940.1","15599395","Caspase-3 is crucial for the differentiation of bone marrow stromal stem cells by influencing TGF-beta/Smad2 pathway and cell cycle progression"
> "P70677-1","RefSeq","NP_033940.1","11374883","Cochlear neuron function"
> "P61014-1","RefSeq","NP_075618.1","30299255","Here the show that DWORF has a higher apparent binding affinity for SERCA than PLN and that DWORF overexpression mitigates the contractile dysfunction associated with PLN overexpression, substantiating its role as a potent activator of SERCA. Publication Status: Online-Only"
10367a13879
> "P70333-1","RefSeq","NP_063921.1","25846207","HnRNP C and hnRNP H bind to the 3'-UTR of the circadian clock gene Period 2 (mPer2)."
10371a13884,13893
> "Q8CFN5-1","RefSeq","NP_079558.1","30521808","Deletion of Mef2c in the early myocardial lineage using Nkx2-5(Cre) resulted in cardiac and vascular abnormalities that were indistinguishable from the defects in the global Mef2c knockout. In contrast, early deletion of Mef2c in the vascular endothelium using an Etv2::Cre line active prior to the onset of Mef2c expression resulted in viable offspring that were indistinguishable from wild type controls."
> "Q8CFN5-1","RefSeq","NP_079558.1","30305329","Mef2c degradation was mediated by Skp2 E3 ligase"
> "Q8VCW4-1","RefSeq","NP_062322.2","29768176","Data show that Unc-93 homolog B1 (UNC93B1) is critical for maintaining Toll-like receptors (TLRs) expression."
> "Q8VCW4-1","RefSeq","NP_062322.2","16415873","Identified 'triple D' (3d), a recessive N-ethyl-N-nitrosourea-induced mutation and phenotype in which no signaling occurs via the intracellular Toll-like receptors 3, 7 and 9"
> "Q3TJD7-1","RefSeq","NP_080407.3","27792740","Primary endogenous regulator of platelet-dependent hemostasis Publication Status: Online-Only"
> "Q3TJD7-1","RefSeq","NP_080407.3","26556890","PDLIM7 is a bona fide skeletal muscle substrate of Nedd4-1."
> "Q3TJD7-1","RefSeq","NP_080407.3","25677945","Findings describe a positive regulatory effect of LMP-1 on BMP-2 expression and BMP-2-mediated osteogenesis. This effect occurs through activation of ERK1/2 pathway and subsequent upregulation of Runx2 transactivity."
> "Q3TJD7-1","RefSeq","NP_080407.3","25032549","LMP is an important determinant of weight and length, female bone density, and marrow stromal cell propensity for mineralization."
> "Q3TJD7-1","RefSeq","NP_080407.3","21060154","The LIM domain protein Enigma directly interacts with MDM2 to form a ternary complex with p53 in embryonic fibroblasts"
> "Q3TJD7-1","RefSeq","NP_080407.3","20706776","LMP-1 showed spatiotemporal expression patterns during molar development.[LMP-1]"
10377a13900,13901
> "Q9Z0L2-1","RefSeq","NP_033841.1","28270618","HGF supports hindlimb motor neurons through c-Met; CNTF supports subsets of axial motor neurons through CNTFRalpha; and Artemin acts as the first survival factor for parasympathetic preganglionic motor neurons through GFRalpha3/Syndecan-3 activation."
> "Q9Z0L2-1","RefSeq","NP_033841.1","25635057","RET coupling to ERK and Akt depends strongly on artemin concentration, and it is highest at the low (~100 pM) artemin levels required for neurite outgrowth."
10382a13907,13916
> "Q9ERS7-1","RefSeq","NP_573456.1","29241623","IL-36R likely contributes to acute kidney injury pathogenesis through NF-kB activity and IL-6 and TNF-a upregulation."
> "Q9ERS7-1","RefSeq","NP_573456.1","28857172","Data show that Interleukin-36 receptor (IL-36R)-deficient fibroblast-like synoviocytes (FLS) had a limited capacity to support plasma cells (PC) survival compared to wild-type FLS."
> "Q9ERS7-1","RefSeq","NP_573456.1","28327619","These findings reveal a fundamental contribution for the IL-36/IL-36R axis in regulating the Treg-Th9 cell balance with broad implications for Th cell-mediated disorders, such as inflammatory bowel diseases and particularly ulcerative colitis"
> "Q9JJJ3-1","RefSeq","NP_071309.1","30266683","Downregulation of aquaporin 9 exacerbates beta-amyloid-induced neurotoxicity in Alzheimer's disease models in vitro and in vivo."
> "Q9JJJ3-1","RefSeq","NP_071309.1","29890131","AQP7 and GLUT1 mRNA and protein have a higher expression in T1DM mice, but the levels of AQP9 mRNA and protein are not changed in the lung difference between normal and T1DM mice. T1DM may increase the expression of transporters of trivalent inorganic arsenic."
> "Q9JJJ3-1","RefSeq","NP_071309.1","29566083","AQP9 -selectively expressed in catecholaminergic neurons-is permeable to MPP+ and this aquaglyceroporin contributes to the selective vulnerability of nigral dopaminergic neurons by providing an entry route for parkinsonogenic toxins. Publication Status: Online-Only"
> "Q9JJJ3-1","RefSeq","NP_071309.1","28419510","The results of this study show Increase of aquaporin 9 expression in astrocytes participates in astrogliosis."
> "Q9JJJ3-1","RefSeq","NP_071309.1","17360690","AQP9 is important for hepatic glycerol metabolism and may play a role in glycerol and glucose metabolism in diabetes mellitus."
> "Q9JJJ3-1","RefSeq","NP_071309.1","16698796","AQP9 has a role in osteoclast differentiation, specifically in the fusion process"
> "Q9JJJ3-1","RefSeq","NP_071309.1","12351427","Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9."
10385a13920,13921
> "Q9JKU8-1","RefSeq","NP_387501.1","29971487","Homozygous Lmx1a mutant mice (Dreher) are deaf with dysmorphic ears with an abnormal morphogenesis and fused and misshapen sensory organs; however, computed tomography performed on a hearing-impaired family member did not reveal any cochleovestibular malformations."
> "Q9JKU8-1","RefSeq","NP_387501.1","29769265","We provide genetic evidence that a transcription factor, Lmx1a, interacts with its negative regulator, Lmo4, to pattern various vestibular and auditory components of the mammalian inner ear."
10388,10389d13923
< "Q8CFN5-1","RefSeq","NP_001334493.1","30521808","Deletion of Mef2c in the early myocardial lineage using Nkx2-5(Cre) resulted in cardiac and vascular abnormalities that were indistinguishable from the defects in the global Mef2c knockout. In contrast, early deletion of Mef2c in the vascular endothelium using an Etv2::Cre line active prior to the onset of Mef2c expression resulted in viable offspring that were indistinguishable from wild type controls."
< "Q8CFN5-1","RefSeq","NP_001334493.1","30305329","Mef2c degradation was mediated by Skp2 E3 ligase"
10396a13931
> "Q8K0T7-1","RefSeq","NP_001074622.1","25355221","We conclude that Munc13-3 is responsible for an additional step of molecular and/or positional 'superpriming' that substantially increases the efficacy of Ca(2+)-triggered release."
10401a13937,13940
> "Q61818-1","RefSeq","NP_033047.2","30275311","Haploinsufficiency of Retinoic Acid Induced 1 causes Smith-Magenis syndrome."
> "Q61818-1","RefSeq","NP_033047.2","27693255","Rai1 preferentially occupies DNA regions near active promoters and promotes the expression of a group of genes involved in circuit assembly and neuronal communication. Behavioral analyses demonstrated that pan-neural loss of Rai1 causes deficits in motor function, learning, and food intake."
> "Q61818-1","RefSeq","NP_033047.2","25752576","Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production."
> "Q61818-1","RefSeq","NP_033047.2","25127133","Mice haploinsufficient for Rai1 fed a high carbohydrate or a high fat diet gained weight at a significantly faster rate than their wild type littermates. Erratum:[PLoS One. 2014;9(11):e114092. Hahn, Natalie H [corrected to Hahn, Natalie C]] Publication Status: Online-Only"
10413a13953,13954
> "Q9D387-1","RefSeq","NP_083806.2","30867010","LAMP5 plays a pivotal role in sensorimotor processing in the brainstem and spinal cord. Publication Status: Online-Only"
> "Q9D387-1","RefSeq","NP_083806.2","27272053","Results show that in mice LAMP5 protein is specifically expressed in subpopulations of GABAergic neurons where it localizes at synaptic terminals, overlapping with VGAT and provide evidence for a fine-tuning function of LAMP5 in evoked GABAergic synaptic transmission. Publication Status: Online-Only"
10428a13970,13971
> "Q8BVL9-1","RefSeq","NP_848481.2","26627310","JAKMIP1 loss dysregulates neuronal translation during synaptic development and results in social deficits and other autistic-like behaviors."
> "Q8BVL9-1","RefSeq","NP_848481.2","19386132","Marlin-1 is enriched in restricted areas of the brain including olfactory bulb, cerebral cortex, hippocampus and cerebellum; it is abundant in dendrites and axons of hippocampal neurons, associated with microtubules at the ultrastructural level. Publication Status: Online-Only"
10447a13991
> "Q8BH44-1","RefSeq","NP_780693.2","29162887","CORO2B is a novel podocyte enriched protein influencing cytoskeletal plasticity and stress adaptation. Publication Status: Online-Only"
10460c14004,14008
< "Q9ER62-1","RefSeq","NP_001298074.1","29973541","Transmembrane TNF, TNFR2 and TNFR1 (indirectly) are critical for preventing inflammation during BCG-induced pleurisy in mice. Publication Status: Online-Only"
---
> "Q8VI36-1","RefSeq","NP_598676.2","28954813","Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin."
> "Q8VI36-1","RefSeq","NP_598676.2","28935710","Paxillin and FAK function cell-autonomously to control migrating neuron morphology and speed during cortical development."
> "Q9CR67-1","RefSeq","NP_084384.1","31048699","Study shows that TMEM33 interacts with the ion channel polycystin-2 at the endoplasmic reticulum (ER) membrane, enhancing its opening over the whole physiological calcium range in ER liposomes fused to planar bilayers. Results identify a key role for TMEM33 in the regulation of intracellular calcium homeostasis of renal proximal convoluted tubule cells and establish a causal link between TMEM33 and acute kidney injury. Publication Status: Online-Only"
> "Q8BID6-1","RefSeq","NP_082401.1","22615130","Expression of the Btbd4 defines the classical dendritic cell lineage"
> "Q8BID6-1","RefSeq","NP_082401.1","22615127","Zbtb46 may help enforce dendritic cell identity by restricting responsiveness to non-dendritic cells growth factors and may serve as a useful marker to identify rare dendritic cell progenitors"
10464a14013,14021
> "P97368-1","RefSeq","NP_032653.2","22987645","Data have demonstrated the presence of Meis, Pbx, and Prep proteins during early lineage segregation in mammals: Meis1, Meis3, Pbx1, Pbx2, Pbx3, and Prep1 in the mouse."
> "P97368-1","RefSeq","NP_032653.2","21059917","Meis3 is abundantly expressed in pancreatic islets and beta-cells and regulates beta-cell survival through 3-phosphoinositide-dependent protein kinase 1 (PDK1)."
> "P97368-1","RefSeq","NP_032653.2","18223676","Novel collaboration between Icsbp deficiency and Meis1/Meis3 in the acceleration of chronic myeloid leukemia-like disease."
> "P97368-1","RefSeq","NP_032653.2","12397630","The mRNA level of this protein was elevated in limb buds after treatment with ectopic acid."
> "Q5RJH3-1","RefSeq","NP_001008420.1","20723620","Spatio-temporal mRNA distribution pattern of Cdh12 and Cdh22 during CNS development; demonstrate presence of Cdh12 and Cdh22 mRNA in both excitatory and inhibitory neurons in adult CNS including cerebellum, neocortex, hippocampus and subcortical nuclei"
> "Q6ZWS8-1","RefSeq","NP_079563.2","29546395","SPOP is required for embryo implantation, endometrial decidualization, and uterine health in the mouse"
> "Q6ZWS8-1","RefSeq","NP_079563.2","29202479","No evidence that ERG is an effector of SPOP mutation in human prostate cancer or mouse models."
> "Q6ZWS8-1","RefSeq","NP_079563.2","28412462","Results demonstrate a negative role of Spop in the level and activity of Gli3, Shh signaling and ventral spinal cord patterning."
> "Q6ZWS8-1","RefSeq","NP_079563.2","12183056","MacroH2A1.2 binds the nuclear protein Spop."
10468a14026,14031
> "Q8BPM6-1","RefSeq","NP_848895.2","27129882","Regulation of expression level and splicing of RIC-3 in brain and in immune cells following inflammation enables regulation of nicotinic acetylcholine receptor functional expression. Publication Status: Online-Only"
> "Q8BPM6-1","RefSeq","NP_848895.2","20668195","In neurons, Ric-3 ER retention appears to promote transport within the dendritic ER subcompartment, thereby restricting 7 trafficking to dendrites and preventing axonal transport."
> "Q6NZH9-1","RefSeq","NP_997129.1","29490280","RasGRP3 is specifically required for GNAQ/GNA11-driven Ras activation and tumorigenesis."
> "Q6NZH9-1","RefSeq","NP_997129.1","27465532","RasGRP1/3-deficient progenitors show impaired migration toward the CCR9 ligand, CCL25, suggesting that RasGRP1 and RasGRP3 may regulate progenitor entry into the thymus through a CCR9-dependent mechanism."
> "Q6NZH9-1","RefSeq","NP_997129.1","25118589","RasGRP3 limits inflammatory response by activating Rap1 on low-intensity pathogen infection, setting a threshold for preventing excessive inflammatory response. Publication Status: Online-Only"
> "Q6NZH9-1","RefSeq","NP_997129.1","23308188","RasGRP1, but not RasGRP3, is required for thymocyte positive selection and invariant natural killer T cell selection."
10477,10478d14039
< "Q9D6Z0-1","RefSeq","NP_079814.1","28726787","Results uncover an in vivo role for ALKBH7 in mediating a sexually dimorphic tissue response to alkylation damage that could influence individual responses to chemotherapies based upon alkylating agents. Publication Status: Online-Only"
< "Q9D6Z0-1","RefSeq","NP_079814.1","23572141","The first direct demonstration that murine Alkbh7 is a mitochondrial resident protein involved in fatty acid metabolism and the development of obesity."
10482a14044,14046
> "P51432-1","RefSeq","NP_032900.2","28615442","Data, including data from studies using transgenic/knockout mice, suggest that Ppp1ca and Gnb1 interact in quiescent platelets; then, Ppp1ca and Plcb3 interact during platelet aggregation; thus, Gnb1 enlists Ppp1ca to modulate G protein-coupled receptor signaling. (Ppp1ca = protein phosphatase 1, catalytic subunit alpha; Gnb1 = guanine nucleotide-binding protein, subunit beta-1; Plcb3 = phospholipase C, subunit beta-3)"
> "P51432-1","RefSeq","NP_032900.2","26468229","Gnb isoforms control a signaling pathway comprising Rac1, Plcbeta2, and Plcbeta3 leading to LFA-1 activation and neutrophil arrest in vivo"
> "P51432-1","RefSeq","NP_032900.2","24412367","Plcb3-deficient mice spontaneously develop atopic dermatitis-like skin lesions."
10493a14058,14060
> "Q9Z262-1","RefSeq","NP_061247.1","29324052","When pregnant dams were further exposed to secondhand smoke, Claudin-6 mRNA expression in embryos decreased through gestation and into post-natal periods."
> "Q9Z262-1","RefSeq","NP_061247.1","27763528","These data reveal captivating information suggesting a role for Cldn6 in lungs exposed to tobacco smoke and suggest that further research is necessary in order to fully explain roles for tight junctional components such as Cldn6 Publication Status: Online-Only"
> "Q9Z262-1","RefSeq","NP_061247.1","27982694","Cldn6 was markedly decreased in the lungs of mice exposed to acute tobacco sm"
10495a14063,14069
> "E9Q1A5-1","RefSeq","NP_780766.3","28637206","The heightened osteoanabolism of the Nmp4-/- skeleton enhances the effectiveness of diverse osteoporosis treatments, in part by increasing hyperanabolic osteoprogenitors. Nmp4 provides a promising target pathway for identifying barriers to pharmacologically induced bone formation."
> "E9Q1A5-1","RefSeq","NP_780766.3","27129771","Sustained protein synthesis sensitized cells to pharmacological induction of the Unfolded Protein Response (UPR), and the observed decrease in cell viability was restored upon inhibition of GADD34 activity. We conclude that NMP4 is a key regulator of ribosome biogenesis and the UPR, which together play a central role in determining cell viability during endoplasmic reticulum stress."
> "E9Q1A5-1","RefSeq","NP_780766.3","26378628","NMP4 deficiency suppressed the arthritis-induced increase in bone resorption, expression of RANKL and MMP-3 mRNA."
> "E9Q1A5-1","RefSeq","NP_780766.3","15669012","Transformation of 3T3 fibroblasts by CIZ/NMP4 fusions is dependent on DNA-binding and might involve transactivation of CIZ target genes"
> "E9Q1A5-1","RefSeq","NP_780766.3","15716059","Two adjacent promoters of Nmp4 P(1) [-2521 nucleotide (nt)/-597 nt] and P(2) (-2521 nt/+1 nt) initiate transcription of alternative first exons (U(1) and U(2))."
> "E9Q1A5-1","RefSeq","NP_780766.3","15189450","Impaired spermatogenesis and male infertility occurred in Nmp4-disrupted mice."
> "E9Q1A5-1","RefSeq","NP_780766.3","12052465","Localization in the cytoplasm of osteoblasts"
10499a14074
> "Q497N6-1","RefSeq","NP_067415.2","16985004","Results show Dcd8 was not testis specific."
10501a14077,14080
> "Q6P069-1","RefSeq","NP_079894.2","29273681","Sorcin is involved in the regulation of Ca(+2)-mediated angiogenesis via VEGF/PI3K/Akt pathway in endometrial cells."
> "Q6P069-1","RefSeq","NP_079894.2","29174767","Sorcin deficiency may trigger cardiac ventricular arrhythmias due to Ca(2+) disturbances"
> "Q6P069-1","RefSeq","NP_079894.2","26822088","Sorcin links pancreatic beta cells lipotoxicity to calcium stores and provides a target for intervention in type 2 diabetes."
> "Q6P069-1","RefSeq","NP_079894.2","12824171","Sorcin is a potent inhibitor of both spontaneous and ICa-triggered RyR activity and is kinetically capable of playing a role in terminating the positive feedback loop of Ca2+-induced Ca2+ release"
10505a14085,14088
> "Q8CAS9-1","RefSeq","NP_084529.1","28105679","This study shows that Parp9-deficient mice are viable, fertile, and do not show any overt phenotype; Parp9 is dispensable for B-cell development, and that Parp9 is not essential for double-stranded DNA break repair, or that strong compensatory mechanisms exist"
> "Q8CAS9-1","RefSeq","NP_084529.1","27796300","PARP9 and PARP14 regulate macrophage activation in macrophage cell lines treated with either IFNgamma or IL-4; PARP14 silencing induces pro-inflammatory genes and STAT1 phosphorylation in M(IFNgamma) cells, whereas it suppresses anti-inflammatory gene expression and STAT6 phosphorylation in M(IL-4) cells Publication Status: Online-Only"
> "Q8CAS9-1","RefSeq","NP_084529.1","26479788","Data indicate that PARP polymerase PARP9-E3 ligase DTX3L interacts with STAT1 transcription factor and enhances translocation of STAT1 to the nucleus."
> "Q8CAS9-1","RefSeq","NP_084529.1","18069692","Data show that Parp-9 is developmentally regulated, and prominently expressed in the thymus and specific regions of the brain and gut."
10507a14091,14097
> "O88576-1","RefSeq","NP_001162117.1","26240152","Analysis of the interaction of amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin"
> "O88576-1","RefSeq","NP_001162117.1","19478081","In contrast to its association with ACE2 observed in Xenopus oocytes, experiments with ace2 and collectrin null mice demonstrate that in vivo it is Collectrin, a smaller homologue of ACE2, that is required for functional expression of XT2 in kidney."
> "O88576-1","RefSeq","NP_001162117.1","15121838","The XT2 orphan transporter is involved in glycine reabsorption, and the absence of this transporter is sufficient to cause hypertension."
> "Q9Z131-1","RefSeq","NP_036024.2","26845758","The binding to and phosphorylation of Sab by p-JNK on the outer mitochondrial membrane leads to SHP1-dependent and DOK4-dependent inactivation of p-Src on the inner membrane; inactivation of mitochondrial Src inhibits electron transport and increases reactive oxygen species release, which sustains JNK activation and promotes cell death and organ injury."
> "Q9Z131-1","RefSeq","NP_036024.2","25666017","The interplay of p-JNK with mitochondrial Sab leads to impaired respiration, ROS production, sustained JNK activation, and apoptosis."
> "Q9Z131-1","RefSeq","NP_036024.2","24407242","ER stress triggers an interaction of JNK with mitochondrial Sab, which leads to impaired respiration and increased mitochondrial reactive oxygen species. Publication Status: Online-Only"
> "Q9Z131-1","RefSeq","NP_036024.2","21844199","JNK-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice"
10508a14099,14100
> "P09632-1","RefSeq","NP_034591.1","30211955","HoxB8 neutrophils represent a faithful experimental model system for the analysis of Fc and integrin receptor-dependent neutrophil functions."
> "P09632-1","RefSeq","NP_034591.1","30210501","CRISPR/Cas9 Immunoengineering of Hoxb8-Immortalized Progenitor Cells for Revealing CCR7-Mediated Dendritic Cell Signaling and Migration Mechanisms in vivo. Publication Status: Online-Only"
10520a14113,14114
> "P00687-1","RefSeq","NP_031472.2","26098870","Data indicate that the amylase 1 (AMY1) copy number in an individual's genome is generally even and partially correlates with nearby single nucleotide polymorphism (SNPs), which do not associate with body mass index (BMI)."
> "P00687-1","RefSeq","NP_031472.2","26132294","Our findings suggest that AMY1 copy number differences play a role in childhood-onset obesity but the effect differs between males and females. Publication Status: Online-Only"
10525a14120,14123
> "A2ASZ8-1","RefSeq","NP_666230.2","28588221","These findings suggest that KD feeding induces expression of the muscle circadian gene Slc25a25 via neural pathways, and that SLC25A25 might be involved in muscle thermogenesis under KD-induced hypothermia in mammals. Publication Status: Online-Only"
> "A2ASZ8-1","RefSeq","NP_666230.2","21296886","Induction of Slc25a25 in mice with an intact gene may contribute to an alternative thermogenic pathway for the maintenance of body temperature during cold stress."
> "Q80YA3-1","RefSeq","NP_789815.3","30221923","DDHD1 is a principal regulator of bioactive lysophosphatidylinositol lipids and other lysophospholipids, as well as phosphatidylinositol phosphates, in the mammalian nervous system, pointing to a potential role for these lipid pathways in hereditary spastic paraplegia"
> "Q80YA3-1","RefSeq","NP_789815.3","24599962","A possible mechanism of PA regulation of the mitochondrial membrane and demonstrate an in vivo function of PA-PLA1 in the organization of mitochondria during spermiogenesis."
10528,10533c14126,14127
< "Q8C0R7-1","RefSeq","NP_001025100.1","20675388","ZMYND15 represents the first transcriptional repressor identified to be essential for sperm production and male fertility."
< "Q18PE0-1","RefSeq","NP_001335203.1","28069867","The Dok-7's C-terminal region plays a key, but not fully essential, role in MuSK activation and NMJ formation."
< "Q18PE0-1","RefSeq","NP_001335203.1","27091576","These results demonstrate that correct, physiological levels of dok-7 expression are required for the postnatal maintenance of neuromuscular junctions."
< "Q18PE0-1","RefSeq","NP_001335203.1","26198629","Protein kinase CK2 interacts at the neuromuscular synapse with Rapsyn, Rac1, 14-3-3gamma, and Dok-7 proteins and phosphorylates the latter two."
< "Q18PE0-1","RefSeq","NP_001335203.1","18165682","The COOH-terminal NES and Src homology 2 target motifs play key roles in Dok-7/MuSK signaling for neuromuscular synaptogenesis."
< "Q18PE0-1","RefSeq","NP_001335203.1","16794080","Dok-7 is essential for neuromuscular synaptogenesis through its interaction with MuSK"
---
> "P61793-1","RefSeq","NP_766577.1","30622227","HEB may be required for a proper regulation of Lpar1 expression in the embryonic neocortical neuroblast cells."
> "P61793-1","RefSeq","NP_766577.1","29051083","Study shows that lysophosphatidic acid (LPA) propagates post-injury schwann cell (SC) dedifferentiation through lysophosphatidic acid 1 signaling. These data indicate that LPA may be a critical factor that shifts SCs towards a post-injury phenotype and contributes to the onset of Wallerian degeneration."
10534a14129,14133
> "Q8BLY1-1","RefSeq","NP_071711.2","25750188","SMOC1 is an activin-like kinase antagonist produced by endothelial cells that tips TGF-beta signalling towards ALK1 activation"
> "Q8BLY1-1","RefSeq","NP_071711.2","16736127","Expression of SMOC-1 examined in the early embryo day 7, as well as in following embryonic stages on days 12, 14, 16 & 18; broad and organ-specific distribution suggests multifunctional roles of SMOC-1 during mouse embryogenesis"
> "P0DPB4-1","RefSeq","NP_038956.2","27979964","Work reveals that IQCJ-SCHIP1 interacts with several major nodal proteins, and we suggest that it contributes to a higher organizational level of the AnkG/betaIV-spectrin network critical for node integrity"
> "P0DPB4-1","RefSeq","NP_038956.2","25950943","CK2-regulated IQJC-SCHIP-1 association with AnkG contributes to axon initial segment maintenance."
> "P0DPB4-1","RefSeq","NP_038956.2","25953347","A new and early role for SCHIP1 during axon development and establishment of the anterior commissure, is identified."
10536d14134
< "Q8BKX1-1","RefSeq","NP_001032844.2","28067313","Double knockout of IRSp53 and its closest family member, IRTKS, resulted in exacerbated placental abnormalities, particularly in spongiotrophoblast differentiation and development, giving rise to complete embryonic lethality. Publication Status: Online-Only"
10539a14138,14140
> "O35326-1","RefSeq","NP_033185.2","28592444","Posttranslational modification of SR proteins underlies the regulation of their mRNA export activities and distinguishes pluripotent from differentiated cells."
> "O35326-1","RefSeq","NP_033185.2","23536862","Overexpression of SRSF5 enhances a specific endogenous pre-mRNA splicing event in proliferating cells, but not in differentiating cells, due to proteasome-mediated targeting of both endogenous and transfection-derived SRSF5."
> "O35326-1","RefSeq","NP_033185.2","15684423","Data show that Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of SRp40."
10540a14142,14145
> "Q91VY6-1","RefSeq","NP_631939.1","22488362","Data suggest a suppressive function for Cytip in mouse dendritic cells in limiting immune responses."
> "Q91VY6-1","RefSeq","NP_631939.1","19744714","Cybr represses the expression of T-bet and IFN-gamma via an inhibition of p38 in T-cells and consequently reduces host resistance to bacterial infection in mice."
> "Q91VY6-1","RefSeq","NP_631939.1","16914744","These data suggest that Cybr is not absolutely required for hematopoietic cell development or function, but stem cells lacking Cybr are at a developmental disadvantage compared to wild-type cells."
> "Q91VY6-1","RefSeq","NP_631939.1","16809763","Expression in vivo is differentially modulated by type 1 cytokines during lymphocyte maturation"
10546d14150
< "Q924W7-1","RefSeq","NP_001001326.1","29650351","ST5 overexpression has no mitogenic effect on the adult beta-cell under basal and metabolically challenged states."
10557c14161
< "Q62432-1","RefSeq","NP_001239410.1","30651315","Our findings generate a mouse model to study the roles of SMAD2/3 in the uterus and serve to provide insight into the mechanism by which the endometrium can escape the plethora of growth regulatory proteins"
---
> "Q5BLK4-1","RefSeq","NP_705766.3","28665939","Following an intratracheal challenge with S. pneumoniae, Zcchc6 deficiency led to a modest but significant increase in the expression of select cytokines including IL-6, CXCL1, and CXCL5. These findings were recapitulated in vitro whereby Zcchc6-deficient macrophages exhibited similar increases in cytokine expression due to bacterial stimulation Publication Status: Online-Only"
10577a14182
> "Q3TWI9-1","RefSeq","NP_937810.2","27045885","TMEM63 proteins may serve as an osmolarity sensitive ion channel for the osmoreception."
10579,10580c14184,14187
< "Q9R1T4-1","RefSeq","NP_001170795.1","29400567","Sept6 and Pigx might participate in the pathogenesis of high blood pressure."
< "Q9R1T4-1","RefSeq","NP_001170795.1","28751190","Data suggest a regulatory role for septin 6 in long-term hematopoietic stem cells (HSCs) function and lymphoid lineage differentiation."
---
> "Q62178-1","RefSeq","NP_038686.3","29981480","Sema4A functions through postsynaptic Plexin-B2 for excitatory synapse development."
> "Q62178-1","RefSeq","NP_038686.3","29273643","We highlight a common but age-related Sema4a-mediated pathway by which plasmacytoid dendritic cells and microbial colonization induce T reg cell expansion to protect against severe bronchiolitis and subsequent asthma."
> "Q62178-1","RefSeq","NP_038686.3","28007914","Suggest a role for Plexin-B1 as a ligand and Sema4A as a receptor and characterize a reverse signaling pathway downstream of Sema4A regulating cell migration via Scrib."
> "Q62178-1","RefSeq","NP_038686.3","26116513","SEMA4A is required for optimal activation of mTORC1 in CD8+ T cells."
10582,10591c14189
< "O35474-1","RefSeq","NP_001033076.1","12074641","Acts as an angiogenic factor in the context of solid tumor formation; the increase in vascularization accelerates tumor growth through decreased apoptosis"
< "O35474-1","RefSeq","NP_001033076.1","11959660","Mediates vascular smooth muscle cells adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3)"
< "Q9WTJ6-1","RefSeq","NP_001034746.1","14648882","Data suggest that tesmin transcription may be controlled by two different mechanisms during male and female meiosis."
< "Q9WTJ6-1","RefSeq","NP_001034746.1","12606435","Tesmin is involved in multiple stages of spermatogenesis and spermiogenesis"
< "Q9WTJ6-1","RefSeq","NP_001034746.1","11803038","Regulation of the tesmin nucleocytoplasmic shuttling by the effect of metal stress"
< "Q99N50-1","RefSeq","NP_001276512.1","24284068","Our findings indicate that Slp2-a controls renal cell size through regulation of Rap-ezrin signaling independently of Rab27."
< "Q99N50-1","RefSeq","NP_001276512.1","22767581","Slp2-a is required for targeting of the signaling molecule podocalyxin to the apical membrane in a Rab27A-dependent manner."
< "Q99N50-1","RefSeq","NP_001276512.1","20729199","Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons"
< "Q99N50-1","RefSeq","NP_001276512.1","15543135","Loss of Slp2-a protein also induced a change in melanocyte morphology, from their normal elongated shape to a more rounded shape, which depended on the phospholipid-binding activity of Slp2-a"
< "Q99N50-1","RefSeq","NP_001276512.1","11773082","Synaptotagmin-like protein 2-a (Slp2-a) contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slp2-a specifically and directly binds the GTP-bound form of Rab27A."
---
> "Q99N48-1","RefSeq","NP_899226.2","11773082","Synaptotagmin-like protein 3-a (Slp3-a) contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slp3-a specifically and directly binds the GTP-bound form of Rab27A."
10599,10600c14197,14204
< "Q80U04-1","RefSeq","NP_001020480.1","27195677","Praja2 regulates KSR1 stability and mitogenic signaling. Publication Status: Online-Only"
< "Q80U04-1","RefSeq","NP_001020480.1","24561619","The SIK2-p35-PJA2 complex is essential for glucose homeostasis and provides a link between p35-CDK5 and the AMPK family in excitable cells. Erratum:[Nat Cell Biol. 2014 Apr;16(4):382]"
---
> "Q3UHK3-1","RefSeq","NP_056579.2","29955957","Craniofacial Greb1l RNA expression peaks in mice during this time frame (E8.5). It also peaks in the developing inner ear during E13-E16, after which it decreases in adulthood. The crucial function of Greb1l in craniofacial development is also evidenced in knockout mice, which develop severe craniofacial abnormalities"
> "Q3UHK3-1","RefSeq","NP_056579.2","29100091","A significant association between GREB1L variants and BKA."
> "Q3UHK3-1","RefSeq","NP_056579.2","28911214","GREB1 is a novel progesterone-responsive gene required for endometrial stromal decidualization."
> "Q91VJ5-1","RefSeq","NP_062351.2","25070536","This study demonstrated that in utero gene therapy for Pqbp1-cKO mice by intraperitoneal injection of the PQBP1-AAV vector at E10 successfully rescued microcephaly with preserved cortical structures and improved behavioral abnormalities in Pqbp1-cKO mice."
> "Q91VJ5-1","RefSeq","NP_062351.2","23994472","These findings define PQBP1 and Dynamin 2 as components of a signaling pathway that orchestrates neuronal ciliary morphogenesis in the brain."
> "Q91VJ5-1","RefSeq","NP_062351.2","23874697","The results indicated that Sox2 regulated the transcription of PQBP1 in neural stem progenitor cells. Publication Status: Online-Only"
> "Q91VJ5-1","RefSeq","NP_062351.2","23512658","PQBP1 can affect the alternative splicing of multiple mRNAs and indicate specific affected targets whose splice site determination may contribute to the disease phenotype in PQBP1-linked neurological disorders"
> "Q8C6G0-1","RefSeq","NP_919044.1","29730295","Ifi27 protein localizes to mitochondria, and the expression of Ifi27 can be induced by beta3-adrenergic activation in adipose tissues. Knockdown of Ifi27 leads to reduced expression of key enzymes of tricarboxylic acid cycle, the subunits of electron transport chain, and uncoupling protein 1 (Ucp1) in brown and beige adipocytes."
10601a14206,14209
> "Q06180-1","RefSeq","NP_033003.1","29797458","PTPN2 is an essential STAT3 repressor involved in the maintenance and induction of naive pluripotency."
> "Q06180-1","RefSeq","NP_033003.1","29712668","TCPTP controls Insulin resistance signaling in AgRP neurons to coordinate hepatic glucose production and brown/beige adipocyte glucose uptake in response to feeding/fasting."
> "Q06180-1","RefSeq","NP_033003.1","29444435","A dual role for myeloid PTPN2 in directly regulating inflammasome activation and IL-1beta production to suppress pro-inflammatory responses during colitis but promote intestinal tumor development, is reported."
> "Q06180-1","RefSeq","NP_033003.1","29587266","PTPN2 overexpression in white adipose tissue could significantly reduce macrophages infiltration, the ratio of M1/M2 macrophages and the expression of pro-inflammatory cytokines in white adipose tissue , improving insulin resistance."
10609,10613c14217,14221
< "Q8BPM0-1","RefSeq","NP_080378.2","28682694","The data suggested that Daam1 affected actin assembly during oocyte meiotic division via the regulation of fascin expression."
< "Q8BPM0-1","RefSeq","NP_080378.2","27807130","DAAM1 loss evokes invasive abilities of epithelial cells."
< "Q8BPM0-1","RefSeq","NP_080378.2","27760153","DAAM1 organizes actin filaments into a nodal complex Publication Status: Online-Only"
< "Q8BPM0-1","RefSeq","NP_080378.2","15533824","Daams are expressed in tissues known to require Wnts, so effectors of Wnt signaling during vertebrate development."
< "Q8BPM0-1","RefSeq","NP_080378.2","15464228","Involved in pivotal steps in neuronal cell differentiation and movement"
---
> "Q8CGR6-1","RefSeq","NP_001034131.2","16423834","Kallikrein mK13 is a plausible candidate for the processing enzyme for pro-IL-1beta in the submandibular gland of mice"
> "Q7TN99-1","RefSeq","NP_938042.2","27681423","Topological regulation of synaptic AMPA receptor expression by the RNA-binding protein CPEB3 has been demonstrated."
> "Q7TN99-1","RefSeq","NP_938042.2","20003455","Show that CPEB3 expression is increased in a time-dependent manner during the course of postnatal development, and CPEB3 is localized mostly in the inner retina, including retinal ganglion cells. Publication Status: Online-Only"
> "Q7TN99-1","RefSeq","NP_938042.2","17024188","CPEB3 is a sequence-specific translational regulatory protein."
> "Q7TN99-1","RefSeq","NP_938042.2","12871996","CPEB3 is expressed in the principal cell layers of the hippocampus"
10615,10618d14222
< "Q9R0U0-1","RefSeq","NP_001073856.1","26586428","SRSF10 represses inclusion of PGC1alpha exon 7a."
< "Q9R0U0-1","RefSeq","NP_001073856.1","25627895","The results of this study suggested for the first time that NSSR1 may provide a novel mechanism for reducing neuronal injury after ischemia, probably through regulation on alternative splicing of NCAM-L1 and CREB in astrocytes."
< "Q9R0U0-1","RefSeq","NP_001073856.1","24710272","These results identify SRSF10 as an essential regulator for adipocyte differentiation."
< "Q9R0U0-1","RefSeq","NP_001073856.1","24668663","We further show that an SRSRSK sequence in the RS3 domain may play an important role in the function of NSSR1 in pre-mRNA splicing. Publication Status: Online-Only"
10623a14228,14231
> "Q2VPU4-1","RefSeq","NP_808250.1","29282201","Data (including data from studies in knockout mice) suggest that MondoA shuttles to nucleus of pancreatic beta-cells where it is required for induction of glucose-responsive genes arrestin domain-containing protein 4 (Arrdc4) and thioredoxin interacting protein (Txnip)."
> "Q2VPU4-1","RefSeq","NP_808250.1","27500491","MondoA-directed programs have a key role in the coordinated control of myocyte lipid balance and insulin signaling"
> "Q2VPU4-1","RefSeq","NP_808250.1","26910886","Evaluation of the conservation of ChREBP and MondoA sequences demonstrate that MondoA is better conserved and potentially mediates more ancient function in glucose metabolism. Publication Status: Online-Only"
> "Q2VPU4-1","RefSeq","NP_808250.1","25145386","MondoA is a basic helix-loop-helix/leucine zipper transcription factor that is expressed predominantly in skeletal muscle. Mice deficient for MondoA excel in sprinting, as their skeletal muscles display an enhanced glycolytic capacity."
10630a14239,14242
> "Q8C078-1","RefSeq","NP_663333.1","31164648","CaMKK2 is highly expressed within intratumoral myeloid cells in mouse models of breast cancer, and demonstrate its inhibition within myeloid cells suppresses tumor growth by increasing intratumoral accumulation of effector CD8(+) T cells and immune-stimulatory myeloid subsets. Tumor-associated macrophages isolated from Camkk2 KO mice expressed higher levels of chemokines involved in the recruitment of effector T cells. Publication Status: Online-Only"
> "Q8C078-1","RefSeq","NP_663333.1","29314250","The data presented here underscore the therapeutic potential of targeting CaMKK2 to promote efficacious and rapid healing of bone fractures and as a mechanism to strengthen normal bones."
> "Q8C078-1","RefSeq","NP_663333.1","28981105","We demonstrated that systemic administration of the small molecule CaMKK2 inhibitor, STO-609, to irradiated mice enhanced Hematopoietic stem and progenitor cells (HSPCs)recovery and improved survival. These findings identify CaMKK2 as an important regulator of HSPC regeneration and demonstrate CaMKK2 inhibition is a novel approach to promoting hematopoietic recovery after BM injury. Publication Status: Online-Only"
> "Q8C078-1","RefSeq","NP_663333.1","14586002","Findings suggest CaM kinase kinase beta isoforms are required for the formation of hippocampal long-term memory[LTM], but not needed for contextual, trace fear, and passive avoidance LTM"
10646a14259,14262
> "Q5SSM3-1","RefSeq","NP_778168.2","26969129","RICH2 knockout animals display a selective and highly significant fear of novel objects and increased stereotypic behavior as well as impairment of motor learning. Publication Status: Online-Only"
> "Q5SSM3-1","RefSeq","NP_778168.2","24352656","These results suggested that Rich2 controls dendritic spine morphogenesis and function via inhibition of Rac1."
> "Q5SSM3-1","RefSeq","NP_778168.2","23739967","Knock-down of Rich2 or disruption of Rich2-Shank3 complex, inhibits dendritic spine enlargement."
> "Q5SSM3-1","RefSeq","NP_778168.2","11431473","Shows that the RhoGAP domain of the human RICH2 ortholog can catalyze GTP hydrolysis of both Rac1 and Cdc42, but not of RhoA."
10650,10652c14266,14269
< "Q04646-1","RefSeq","NP_031529.2","25633594","FXYD2 activity may be a fundamental mechanism underlying the persistent hypersensitivity to pain induced by inflammation."
< "Q04646-1","RefSeq","NP_031529.2","23344951","Data suggest that in pancreatic beta cells regulatory subunit of Na,K-ATPase FXYD2 plays a role in Akt signaling pathways associated with cell growth and proliferation."
< "Q04646-1","RefSeq","NP_031529.2","22253804","The transcription factor Runx1 controls FXYD2 expression during the maturation of the somato-sensory system, partly through regulation of the tyrosine kinase receptor Ret."
---
> "Q8CBC6-1","RefSeq","NP_034863.1","15893969","Analysis of NLRR-3 expression revealed regulated expression in the neural system in developing ganglia and motor neurons."
> "Q91WA1-1","RefSeq","NP_079648.1","19805627","The tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis."
> "Q91WA1-1","RefSeq","NP_079648.1","17141802","TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs."
> "Q91WA1-1","RefSeq","NP_079648.1","12875843","MTIM promotes the nuclear localization of TIPIN, and TIPIN is capable of regulating mTIM activity by disrupting the ability of mTIM to form homo-multimeric complexes"
10655a14273,14274
> "Q9D5T0-1","RefSeq","NP_080763.2","28103482","Animals lacking Thorase in DAT+ neurons expressed greater associative learning in a fear conditioning paradigm."
> "Q9D5T0-1","RefSeq","NP_080763.2","24843043","Yeast Msp1 and mammalian ATAD1 are conserved members of the mitochondrial protein quality control system that might promote the extraction and degradation of mislocalized TA proteins to maintain mitochondrial integrity."
10669,10673c14288,14290
< "Q8BX22-1","RefSeq","NP_780512.2","22385656","Plzf antagonizes Sall4 function by displacing Sall4 from cognate chromatin to induce Sall1 expression"
< "Q8BX22-1","RefSeq","NP_780512.2","17060609","Sall4 as an essential transcription factor required for the early development of inner cell mass-derived cell lineages"
< "Q8BX22-1","RefSeq","NP_780512.2","16790473","Sall4 and Sall1 form heterodimers, and a truncated Sall1 caused mislocalization of Sall4 in the heterochromatin; thus, some symptoms of Townes-Brocks syndrome caused by SALL1 truncations could result from SALL4 inhibition."
< "Q8BX22-1","RefSeq","NP_780512.2","16380715","A positive and negative feed-forward circuit between Tbx5 and Sall4 ensures precise patterning of embryonic limb and heart and provides a unifying mechanism for heart/hand syndromes."
< "Q8BX22-1","RefSeq","NP_780512.2","12826753","Cloning and expression analysis; prominent expression in the developing midbrain, branchial arches and the limbs suggests an important function of SALL4 during development of these structures"
---
> "Q9R1W5-1","RefSeq","NP_061252.2","29795344","Study reveals a Notch-Collagen V-Calcitonin receptor signalling cascade that maintains satellite cells in a quiescent state in a cell-autonomous fashion, and raises the possibility that similar reciprocal mechanisms act in diverse stem cell populations"
> "Q9R1W5-1","RefSeq","NP_061252.2","28352669","Lymphatic insufficiency and lymphangiectasia caused by loss of lymphatic Calcrl exacerbates intestinal recovery following mucosal injury and underscores the importance of lymphatic function in promoting recovery from intestinal inflammation Publication Status: Online-Only"
> "Q9R1W5-1","RefSeq","NP_061252.2","11854283","Role in cell surface expression of CRLR/RAMP heterodimeric receptors"
10678a14296,14298
> "Q60997-1","RefSeq","NP_031795.2","28423364","We found that in 3 different populations, mucosal DMBT1 expression was significantly increased (2.5 fold) in individuals with dysplasia compared to multifocal atrophic gastritis without intestinal metaplasia; the increase was also observed in individuals with advanced gastritis and positive H. pylori infection."
> "Q60997-1","RefSeq","NP_031795.2","22069308","A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via DMBT1 and IDO1"
> "Q60997-1","RefSeq","NP_031795.2","9247472","CRP-ductin (also known as Muclin) is upregulated in the pancreas and gastrointestinal tract of CFTR knockout mice.  This sulfated glycoprotein may be a protective molecule upregulated by inflammation."
10692a14313,14316
> "Q9R100-1","RefSeq","NP_062727.1","30047135","Cadherin-17 plays a crucial role in intestinal homeostasis by limiting the permeability of the intestinal epithelium. Cadherin-17 is also a tumour suppressor for intestinal epithelia."
> "Q9R100-1","RefSeq","NP_062727.1","28197418","These findings suggest that cadherin-17 plays a crucial role in mediating breast cancer metastasis to bone marrow."
> "Q9R100-1","RefSeq","NP_062727.1","25612318","These results suggest that CDH17 plays a role in the long-term survival of MBCs, presumably via an 'MBC niche' comprising, at least in part, BEC in the spleen. Publication Status: Online-Only"
> "Q9R100-1","RefSeq","NP_062727.1","15141301","LI-cadherin originated from an ancestral cadherin with five domains by a partial gene duplication event"
10703,10710d14326
< "Q7TS63-1","RefSeq","NP_001139360.1","31366551","Zfat knockdown partially inhibited CD71(-/low)Ter119(-) to CD71(high)Ter119(-) transition of fetal liver erythroid progenitors with impairment in the elevation of CD71 expression.  Zfat plays a critical role for erythropoiesis in the fetal liver"
< "Q7TS63-1","RefSeq","NP_001139360.1","27591365","Findings demonstrated that Zfat regulates the transcription of target genes by binding directly to the TSS proximal region, and that Zfat-target genes play important roles in T-cell homeostasis"
< "Q7TS63-1","RefSeq","NP_001139360.1","27226588","Zfat-deficient T cells show increased numbers of autophagosomes and decreased levels of p62 protein, together indicating that Zfat deficiency promotes lysosomal FoxO1 degradation through autophagy."
< "Q7TS63-1","RefSeq","NP_001139360.1","26168481","Zfat is required for peripheral T-cell homeostasis through IL-7Ralpha expression by controlling the FoxO1 protein."
< "Q7TS63-1","RefSeq","NP_001139360.1","21225468","ZFAT is a critical molecule for cell survival in MEFs and MOLT-4 cells at least in part through the regulation of the apoptosis involved in the BCL-2- and IL6st-mediated pathways."
< "Q7TS63-1","RefSeq","NP_001139360.1","20660741","ZFAT is indispensable for mouse embryonic development and functions as a critical transcription factor for primitive hematopoiesis through direct-regulation of Tal1, Lmo2, and Gata1"
< "Q7TS63-1","RefSeq","NP_001139360.1","18329245","Study shows that ZFAT protein is expressed in B and T lymphocytes in mouse and that ZFAT regulates immune-related genes functionally important for immune responsiveness."
< "Q3UQI9-1","RefSeq","NP_001136253.1","17971504","C330043M08Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
10712,10714d14327
< "P42866-1","RefSeq","NP_001289722.1","30738575","Study showed that MCRT increased colonic contraction via mu- and delta- opioid receptors."
< "P42866-1","RefSeq","NP_001289722.1","30664663","Phosphorylation-deficient Oprm1 improves analgesia and diminishes tolerance but worsens opioid side effects. Publication Status: Online-Only"
< "P42866-1","RefSeq","NP_001289722.1","17284463","Upstream open reading frames in mouse MOR mRNA act as negative regulators of translation through a ribosome leaky scanning mechanism."
10715a14329,14334
> "Q9JK53-1","RefSeq","NP_473418.3","26809092","Therefore, this study established a new role of PRELP in modulating beta-catenin/connexin43 pathway and osteoblast differentiation."
> "Q9JK53-1","RefSeq","NP_473418.3","24670995","When delivered via an AAV vector to the retina of mice, PRELP inhibited laser-induced choroidal neovascularization by 60%. PRELP reduced deposition of membrane attack complex in vivo by 25.5%."
> "Q9JK53-1","RefSeq","NP_473418.3","11731272","Expressed in cartilage throughout both fetal development and post-natal life"
> "Q99KE3-1","RefSeq","NP_444476.1","28275114","Dok-4 can target Elk-4 activity through multiple mechanisms, including binding of the transactivation domain, nuclear exclusion and protein destabilization. Publication Status: Online-Only"
> "Q99KE3-1","RefSeq","NP_444476.1","22982678","The current study have explored in more detail the structure and function of the Dok-4 PTB domain."
> "Q99KE3-1","RefSeq","NP_444476.1","14963042","Dok-4 is a constitutively membrane-localized adapter molecule that may function as an inhibitor of tyrosine kinase signaling in epithelial cells."
10727a14347,14351
> "Q9CWZ3-1","RefSeq","NP_080151.2","28916722","Data suggest that, in embryonic stem cells, Gsk3b/Gsk3a phosphorylate splicing factors (Rbm8a, Srsf9, and Psf) and nucleolar proteins (Npm1 and Phf6); Gsk3b/Gsk3a are key to alternative splicing of close to 190 genes. (Gsk3 = glycogen synthase kinase-3; Rbm8a = RNA binding motif protein 8a; Srsf9 = splicing factor, arginine-serine-rich 9; Psf = replication protein Psf; Npm1 = nucleophosmin 1; Phf6 = PHD finger protein 6)"
> "Q9CWZ3-1","RefSeq","NP_080151.2","28404883","Our data demonstrate that miR-29a regulates the proliferation and differentiation of RPCs by directly targeting Rbm8a, providing us with a better understanding of the molecular mechanisms that govern RPC proliferation and differentiation."
> "Q9CWZ3-1","RefSeq","NP_080151.2","27618312","We first show that Eif4a3 haploinsufficiency phenocopies aberrant neurogenesis and microcephaly of Magoh and Rbm8a mutant mice.we show that genetic ablation of one downstream pathway, p53, significantly rescues microcephaly of all 3 EJC mutant Publication Status: Online-Only"
> "Q9CWZ3-1","RefSeq","NP_080151.2","26094033","This data suggests a novel role of RBM8a in the regulation of neurodevelopment. Publication Status: Online-Only"
> "Q9CWZ3-1","RefSeq","NP_080151.2","23638902","This is the first study that demonstrates the key role of RBM8a on the emotional behaviors in mice."
10732a14357,14362
> "Q8QZS3-1","RefSeq","NP_666130.1","29893999","An essential and novel role of the Flcn-Tfe3-Pgc1 axis in osteoclastogenesis through the metabolic reprogramming of oxidative phosphorylation and purine metabolism, is reported."
> "Q8QZS3-1","RefSeq","NP_666130.1","28363698","These findings suggest that Dihydromyricetin treatment prevents palmitate-induced slow-twitch fibers decrease partially via FLCN-FNIP1-AMPK pathway thereby improving insulin resistance in obesity."
> "Q8QZS3-1","RefSeq","NP_666130.1","28007907","Based on the phenotypes of our preclinical models, the FLCN H255Y mutant protein has lost it tumour suppressive function leading to the clinical manifestations of BHD, whereas the FLCN K508R mutant protein may have a dominant negative effect on the function of wild-type FLCN in regulating kidney cell proliferation and, therefore, act as an oncoprotein"
> "Q8QZS3-1","RefSeq","NP_666130.1","19843504","FLCN is shown as a general tumour suppressor in the kidney."
> "Q8QZS3-1","RefSeq","NP_666130.1","18182616","Homozygous loss of BHD may initiate renal tumorigenesis in the mouse. The conditional BHD knockout mouse may be a useful research model for dissecting multistep kidney carcinogenesis, and rapamycin may be a potential treatment for Birt-Hogg-Dube syndrome"
> "Q8QZS3-1","RefSeq","NP_666130.1","18974783","Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia. Erratum:[PLoS ONE. 2008;3(11). doi: 10.1371/annotation/0f06471c-1993-4144-b785-d58924ac0b5c]"
10736a14367
> "Q9CWV4-1","RefSeq","NP_082301.1","29079788","Mageb16 (41 kDa) is distributed in cytosol and/or in surface membrane in undifferentiated murine embryonic stem cells (ESCs). A transcriptome study performed at differentiated short hairpin RNA (shRNA)-mediated Mageb16 knockdown (KD) ESCs and scrambled control ESCs until a period of 22 days, revealed that Mageb16 KD ESCs mainly differentiated towards cells expressing mesodermal and cardiovascular lineage - gene markers. Publication Status: Online-Only"
10738a14370,14374
> "O88875-1","RefSeq","NP_061237.3","30483269","The HVEM ligand CD160 counterbalances stimulatory signals in highly activated and cytotoxic CD8(+) T effector cells. Publication Status: Online-Only"
> "O88875-1","RefSeq","NP_061237.3","31022694","Findings demonstrate that CD160 provides costimulatory signals to CD8(+) T cells needed for optimal CD8(+) T cell responses and protective immunity during an acute mucosal bacterial infection. Publication Status: Online-Only"
> "O88875-1","RefSeq","NP_061237.3","27702550","CD160 may represent a suitable target for immune intervention in the setting of transplantation to modulate allogeneic cytotoxic responses."
> "O88875-1","RefSeq","NP_061237.3","16764942","CD160 is expressed on the majority of CD8(+) memory T cells as well as recently activated CD8(+) T cells"
> "O88875-1","RefSeq","NP_061237.3","16177084","Knockout Mice BALB C Mice C3H Mice F344 Rats K562 Cells Cultured Cells"
10744a14381,14384
> "Q3UWA6-1","RefSeq","NP_659504.2","30642983","This retrogenic model can be employed to define self-tolerance mechanisms restricting T and B cell responses to GUCY2C to optimize colorectal cancer immunotherapy without autoimmunity."
> "Q3UWA6-1","RefSeq","NP_659504.2","29367634","Relative to controls, guanylate cyclase C knockout mice develop severe systemic illness following oral Salmonella infection, characterized by disrupted intestinal mucus layer, elevated cytokines and organ bacterial load, and reduced animal survival. Publication Status: Online-Only"
> "Q3UWA6-1","RefSeq","NP_659504.2","28916678","Loss of Gucy2c expression is associated with Acute Radiation-Induced GI Syndrome."
> "Q3UWA6-1","RefSeq","NP_659504.2","26773096","Findings show how caloric suppression of the guanylin-GUCY2C signaling axis links obesity to negation of a universal tumor suppressor pathway in colorectal cancer."
10750a14391,14398
> "Q3U108-1","RefSeq","NP_666108.2","29244194","Arid5a regulates the augmentation of OX40 in CD4+ T cells, and impairs destabilizing functions of Regnase-1 and Roquin-1 on OX40 alternative decay element-like stem-loop in the 3' untranslated region"
> "Q3U108-1","RefSeq","NP_666108.2","29358370","High Arid5a expression is associated with inflammation."
> "Q3U108-1","RefSeq","NP_666108.2","28168301","Data showed that regulation of Arid5a by NF-kappaB and MAPK signaling is required to maintain the balance of IL-6 mRNA expression"
> "Q3U108-1","RefSeq","NP_666108.2","28379390","This study shows that Arid5a-deficient mice were highly refractory to bleomycin-induced lung injury"
> "Q3U108-1","RefSeq","NP_666108.2","27671645","Arid5a deficiency resulted in decreased levels of IFN-gamma under Th1 cell conditions, in which T-box expressed in T cells (T-bet) mRNA expression was inhibited."
> "Q3U108-1","RefSeq","NP_666108.2","27022145","T cell-intrinsic role of Arid5a on fate decisions of naive CD4(+)T cells through selective stabilization of Stat3 mRNA."
> "Q3U108-1","RefSeq","NP_666108.2","23676272","Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo."
> "Q3U108-1","RefSeq","NP_666108.2","21346191","AT-rich interactive domain-containing protein 5a (Arid5a) cooperates with Sox9 to stimulate chondrocyte-specific transcription."
10752a14401,14405
> "E9PYI1-1","RefSeq","NP_001161345.1","28522536","A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568"
> "E9PYI1-1","RefSeq","NP_001161345.1","23071813","Zfp568 is both a neural stem cell-maintaining and a brain size-regulating gene."
> "E9PYI1-1","RefSeq","NP_001161345.1","22110054","The results revealed that TRIM28 is differentially required by ZFP568 and other factors during the early stages of mouse embryogenesis."
> "E9PYI1-1","RefSeq","NP_001161345.1","21094155","ZFP568 controls the production of secreted factors required to promote morphogenesis of extraembryonic tissues."
> "E9PYI1-1","RefSeq","NP_001161345.1","18701545","Chato regulates convergent extension in the mouse embryo."
10754a14408,14410
> "O70274-1","RefSeq","NP_033000.1","30483267","PRL2 binds to GTPase Rac. Publication Status: Online-Only"
> "O70274-1","RefSeq","NP_033000.1","28009085","A critical role for PRL2 phosphatase in mediating Notch and c-Kit signals in early T cell progenitors, is reported."
> "O70274-1","RefSeq","NP_033000.1","22791713","Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein"
10762a14419
> "Q9WTR0-1","RefSeq","NP_062698.2","27227700","MiR-155 contributed to the up-regulation of MMP-16, and MMP-16 further degraded aggrecan and collagen type II, leading to the dehydration and degeneration of intervertebral discs"
10771a14429,14432
> "P08505-1","RefSeq","NP_112445.1","30927067","Results suggest that IL-6 contributes, at the very least, to initiation of the neuronal regeneration program in remote dorsal root ganglia neurons after unilateral sciatic nerve injury"
> "P08505-1","RefSeq","NP_112445.1","31073533","Delayed diabetic skin wound healing is associated with increased induction and expression of IL-6 and its receptor, but its function in epidermal keratinocytes may be impaired. Publication Status: Online-Only"
> "P08505-1","RefSeq","NP_112445.1","30904352","Study showed that Malassezia furfur (commensal microorganisms colonized on human skin) produced extracellular vesicles, which could be then internalized into immortalized human keratinocyte HaCaT cell line, as well as mice epidermal keratinocytes. IL-6 expression was significantly enhanced in response to extracellular vesicular stimulation both in vitro and in vivo, in which process the activation of NF-kappaB was invo..."
> "P08505-1","RefSeq","NP_112445.1","30918582","Chronically elevated IL-6 can directly induce DRP-1 and FIS-1 expression through gp130 signaling in cultured myotubes and skeletal muscle. Publication Status: Online-Only"
10773a14435
> "P12960-1","RefSeq","NP_031753.1","30629639","Study confirmed that the HNK-1 epitope was primarily expressed on TNC in the embryonic day 16 mouse brain and promoted neurite outgrowth. That this signal was mediated by CNTN, which is an HNK-1-expressing neuronal receptor. These results suggest that the HNK-1 epitope is a key modifier of TNC and CNTN in the regulation of embryonic brain development. Publication Status: Online-Only"
10775,10776c14437,14440
< "Q9D8F1-1","RefSeq","NP_001334421.1","25153837","ALKBH4 is essential for the development of spermatocytes during the prophase of meiosis. Publication Status: Online-Only"
< "Q9D8F1-1","RefSeq","NP_001334421.1","23673617","ALKBH4-dependent actin demethylation regulates actomyosin function by promoting actin-non-muscle myosin II interaction."
---
> "P07758-1","RefSeq","NP_033269.1","28121484","This study proved that SYVN1 enhances SERPINA1(E342K)/ATZ degradation through SQSTM1-dependent autophagy and attenuates SERPINA1(E342K)/ATZ cytotoxicity."
> "P07758-1","RefSeq","NP_033269.1","27515817","Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation."
> "P07758-1","RefSeq","NP_033269.1","27232337","HAAT inhibits DC activation and function, and it also attenuates autoimmunity and renal damage in the MRL/lpr lupus model Publication Status: Online-Only"
> "P07758-1","RefSeq","NP_033269.1","26295339","FBG1 degrades A1AT-Z through a Beclin1-dependent arm of autophagy. Publication Status: Online-Only"
10782c14446,14447
< "P48678-1","RefSeq","NP_001002011.2","21327075","Lamin C2 as a 'natural lamin deletion mutant' that confers unique properties to the nuclear envelope which would be essential for dynamic telomere repositioning during meiotic prophase I"
---
> "Q9Z2J0-1","RefSeq","NP_035527.3","27463513","Aging modulates vitamin C transporter expression. Renal over-expression of SVCT1 enhances vitamin C reabsorption in aged animals that may synthesize less vitamin C."
> "Q9Z2J0-1","RefSeq","NP_035527.3","22990596","The SVCT1 was induced and localized to the apical membrane of tubular epithelial cells."
10785a14451
> "P08042-1","RefSeq","NP_035872.2","20624068","Taken together, this suggests a role for ZFP1 and ZFP54 in transcriptional regulation in early development."
10790a14457,14461
> "Q3U1T9-1","RefSeq","NP_851992.1","26774822","Dennd1b(-/-) mice were generated and exhibit hyper-allergic responses following antigen challenge. Dennd1b(-/-) TH2, but not other TH cells, exhibit delayed receptor-induced T cell receptor (TCR) downmodulation, enhanced TCR signaling, and increased production of effector cytokines."
> "Q8BJ56-1","RefSeq","NP_080078.2","29320510","Non-cardiac ATGL-mediated modulation of the cardiac lipidome may play an important role in the pathogenesis of chronic heart failure. Publication Status: Online-Only"
> "Q8BJ56-1","RefSeq","NP_080078.2","16009485","Adipose triglyceride lipase (desnutrin) is downregulated by isoproterenol, TNFalpha, and insulin."
> "Q8BJ56-1","RefSeq","NP_080078.2","15550674","Reported that adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis; ATGL and hormone-sensitive lipase (HSL) coordinately catabolize stored triglycerides in adipose tissue [ATGL]"
> "Q8BJ56-1","RefSeq","NP_080078.2","15337759","Desnutrin may have a role in the pathophysiology of obesity"
10792a14464
> "Q9Z1X9-1","RefSeq","NP_033992.2","23643534","Cdc45 Recapitulates Myc-Dependent DNA Replication Stress."
10799a14472
> "P16294-1","RefSeq","NP_032005.1","29419409","Protein S is an important in vivo inhibitor of FIXa. Disruption of the interaction between PS and FIXa causes an increased rate of thrombus formation in mice."
10802a14476,14479
> "Q8VEK6-1","RefSeq","NP_076115.3","25819753","ING3 levels may serve as a surrogate for growth rate, and suggest possible roles for ING3 in growth and self renewal and related diseases such as cancer."
> "Q8VEK6-1","RefSeq","NP_076115.3","24066152","ING3 is essential for asymmetric cell division during mouse oocyte maturation Publication Status: Online-Only"
> "Q9CY57-1","RefSeq","NP_075704.2","20688955","The recently identified chromatin factor Friend of Prmt1 (FOP) is a critical modulator of gamma-globin gene expression."
> "Q9CY57-1","RefSeq","NP_075704.2","19858291","Fop is tightly associated with chromatin, and that it is modified by both asymmetric and symmetric arginine methylation in vivo. Fop plays an important role in the ligand-dependent activation of estrogen receptor target genes, including TFF1 (pS2)."
10810a14488,14491
> "Q9WUB0-1","RefSeq","NP_062679.2","30254289","Data show that keratinocyte-specific deletion of ubiquitin-protein ligases HOIP, HOIL-1 (E-KO) and shank-interacting protein-like 1 protein (SHARPIN) results in severe dermatitis causing postnatal lethality. Publication Status: Online-Only"
> "Q9WUB0-1","RefSeq","NP_062679.2","29695863","Results demonstrate that both HOIP and HOIL-1 are essential LUBAC components and are required for embryogenesis by preventing aberrant cell death; furthermore, they reveal that when LUBAC and caspase-8 are absent, RIPK3 prevents RIPK1 from inducing embryonic lethality by causing defects in fetal haematopoiesis"
> "Q9WUB0-1","RefSeq","NP_062679.2","29694895","LUBAC-tethering motifs (LTMs) located N terminally to the UBL domains of HOIL-1L and SHARPIN heterodimerize and fold into a single globular domain."
> "Q9WUB0-1","RefSeq","NP_062679.2","29109255","HIF regulation of HOIL-1L targets the phosphorylated PKC-zeta for degradation and serves as an hypoxia-adaptive mechanism to stabilize the Na,K-ATPase, avoiding significant lung injury."
10812c14493,14496
< "P97379-1","RefSeq","NP_001074263.1","22357953","Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2."
---
> "P97295-1","RefSeq","NP_032757.2","30857366","It was concluded that PYY signaling through Y2R is not required for the normal appetite-suppressing and body weight-lowering effects of Roux-en-Y gastric bypass in this global knockout mouse model. Publication Status: Online-Only"
> "P97295-1","RefSeq","NP_032757.2","30201296","High Npy2r expression is associated with chronic social defeat stress."
> "Q811D0-1","RefSeq","NP_031888.2","29995933","Subjecting SAP97-cKO mice to a battery of behavioral tests revealed a subtle male-specific cognitive deficit and female-specific motor deficit, while other behaviors were largely unaffected. These data suggest that loss of SAP97 may have a modest contribution to organismal behavior. Publication Status: Online-Only"
> "Q811D0-1","RefSeq","NP_031888.2","28103480","Adrenergic modulation of Kv1.1 was mediated by the signaling scaffold SAP97, which, through direct protein-protein interactions, escorts beta2 signaling to remove Kv1.1 from the dendrite surface. This process promoted spike timing-dependent long-term synaptic potentiation at mouse hippocampal excitatory synapses."
10816c14500
< "Q0GGX2-1","RefSeq","NP_001092747.1","18849567","The Mm.290718/ZFP541 complex is implicated in chromatin remodeling during spermatogenesis and is renamed SHIP1"
---
> "Q62478-1","RefSeq","NP_033555.1","12390899","Unexpectedly, no Xmr message was detected in mouse fetal oocytes"
10823,10826c14507,14516
< "Q2MH31-1","RefSeq","NP_001041470.1","19213785","Chronological regulation of CBE1/Cbe1 expression during pulmonary differentiation suggests involvement in ciliogenesis, with an additional role during early lung development."
< "Q2MH31-1","RefSeq","NP_001041470.1","18163442","SMRP1 was localized to the cytoplasm of step 9-12 elongated spermatids. The protein appeared in a cap formation that covered the caudal sides of the elongated nuclei."
< "Q2MH31-1","RefSeq","NP_001041470.1","17971504","1110017D15Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
< "Q8BXR9-1","RefSeq","NP_001277662.1","26941018","Oxysterol-binding protein-like 6 is a novel regulator of cholesterol trafficking that is part of the miR-33 and miR-27b target gene networks contributing to the maintenance of cholesterol homeostasis."
---
> "Q80VW5-1","RefSeq","NP_082916.1","28966015","C-terminal hairpin extensions of the whirlin PDZ domains mediate the transient supramodular assembly, which improves the binding capacity of the first domain towards its partners, such as Sans."
> "Q80VW5-1","RefSeq","NP_082916.1","28387217","Gpsm2 defines an approximately 200 nm nanodomain at the tips of stereocilia and this localization requires the presence of Galphai3, myosin 15 and whirlin. Erratum:[Nat Commun. 2018 May 25;9:16188. PMID: 29799026] Publication Status: Online-Only"
> "Q9JJZ8-1","RefSeq","NP_034048.1","30418171","Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy."
> "Q9JJZ8-1","RefSeq","NP_034048.1","29131863","AAV8 with capsid Y-F and T-V mutations may be one of the most effective AAV vectors for long-term treatment in a naturally occurring mouse model of CNGA3 achromatopsia Publication Status: Online-Only"
> "Q9ESG2-1","RefSeq","NP_109669.1","23303679","Mutations in ROPN1 and ROPN1L can cause defects in fibrous sheath integrity, sperm motility, and PKA-dependent signaling processes, leading to male infertility. Publication Status: Online-Only"
> "Q9ESG2-1","RefSeq","NP_109669.1","20731842","CABYR expresses at the late stage of spermiogenesis and its isoforms oligomerize and bind with AKAPs and ropporin. Publication Status: Online-Only"
> "Q8CGF7-1","RefSeq","NP_001276455.1","21365688","The study examines the order of formation of two beta-hairpins, the folding mechanism of each individual beta-hairpin, and transition state ensemble of formin-binding protein 28, FBP28 WW domain."
> "Q8CGF7-1","RefSeq","NP_001276455.1","16784750","The first beta-turn is near native-like in the transition state for folding and unfolding. Only after the backbone hydrogen bonds are formed between beta1 and beta2 does a hydrogen bond form to stabilize the first beta-turn."
> "Q3UHL1-1","RefSeq","NP_663596.1","27796283","Camkv has a role in activity-dependent maintenance of dendritic spines Publication Status: Online-Only"
> "D3Z7P3-1","RefSeq","NP_001106854.1","30472430","Results show that GLS1 mutant mice display moderate impairments of hippocampal glutamatergic neurotransmission and moderate changes in adaptive behaviors that have been shown to participate to the development of depressive-like state."
10831a14522,14523
> "Q80XN0-1","RefSeq","NP_780386.3","29242353","Hydrogen peroxide-induced apoptosis was attenuated by Bdh1 overexpression."
> "Q80XN0-1","RefSeq","NP_780386.3","28085920","High BDH1 expression is Associated with Dilated Cardiomyopathy. Publication Status: Online-Only"
10833,10837d14524
< "Q99P72-2","RefSeq","NP_918943.1","30019429","While Nogo-B depletion inhibited tumor angiogenesis, Nogo-B overexpression promoted tumor angiogenesis in a tumor xenograft subcutaneous model of hepatocellular carcinoma."
< "Q99P72-2","RefSeq","NP_918943.1","30055160","These data show for the first time with genetic evidence that Nogo specifically expressed by oligodendrocytes restricts compensatory sprouting after CNS injury."
< "Q99P72-2","RefSeq","NP_918943.1","30051920","Results demonstrate a marked upregulation of the Nogo-A receptor sphingosine 1-phosphate receptor 2 in blood vessels following oxygen-induced retinopathy, while Nogo-A is abundantly expressed in surrounding glial cells. Acute inhibition of Nogo-A with function-blocking antibody 11C7 significantly improved vascular regeneration and consequently prevented pathological pre-retinal angiogenesis."
< "Q99P72-2","RefSeq","NP_918943.1","30040841","Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits Publication Status: Online-Only"
< "Q99P72-2","RefSeq","NP_918943.1","12225863","Expression by growing axons in the developing nervous system"
10840,10841d14526
< "Q8BG26-1","RefSeq","NP_001077276.1","22404429","Nesca functions as an adapter involved in neuronal vesicular transport"
< "Q8BG26-1","RefSeq","NP_001077276.1","15024033","Data suggest that Nesca serves a novel, nuclear-dependent role in neurotrophin-dependent neurite outgrowth."
10845a14531,14532
> "P60154-1","RefSeq","NP_898853.2","24719258","RNASE9 is dispensable for fertility, but the absence of RNASE9 during epididymal transit results in impaired sperm maturation."
> "Q5DTU0-1","RefSeq","NP_666214.1","27029000","We showed that XB130 might play protective roles in lipopolysaccharide-induced systemic septic response and acute lung injury"
10847a14535,14543
> "Q8BQ86-1","RefSeq","NP_780349.3","21982770","These findings indicate that the Chst8 transcript level affects the glycosaminoglycan environment of the cellular prion protein, and as a consequence its ability for conversion into PrP(Sc)."
> "Q8BQ86-1","RefSeq","NP_780349.3","16079414","Analysis of enzymatic properties and expression of GalNAc-4-sulfotransferase-1 and GalNAc-4-sulfotransferase-2"
> "Q8K3A2-1","RefSeq","NP_705825.2","18094117","Inactivation of the Trpt1 gene, encoding the only known mammalian homolog of Tpt1p, eliminates all detectable 2'-phosphotransferase activity from cultured mouse cells but has no measurable effect on spliced Xbp-1 translation."
> "P0CG49-1","RefSeq","NP_035794.1","29422555","Ubb plays a pivotal role in neural stem cell differentiation to suppress Notch signaling, but not in the subsequent maturation stages of neurons that had already been differentiated. Publication Status: Online-Only"
> "P0CG49-1","RefSeq","NP_035794.1","28285139","Data indicate that levels of repressor element-1 silencing transcription factor (REST) are elevated in polyubiquitin-B knockout (Ubb -/-) cells."
> "Q8BVD5-1","RefSeq","NP_001155092.1","27001270","MPP7 as a novel candidate gene for Primary open angle glaucoma. Publication Status: Online-Only"
> "Q8VDI1-1","RefSeq","NP_849147.1","29217193","These findings identify Epsti1 as a modulator of macrophage activation and polarization via the Stat1 and p65 pathways, and suggest a potentially important role of Epsti1 in immunotherapies against inflammatory diseases."
> "P20917-1","RefSeq","NP_001333014.1","28522736","We show that myelin-associated glycoprotein or CNS myelin, in general, inhibit rodent Schwann cell migration and induce their death via cleavage of the neurotrophin receptor p75."
> "P20917-1","RefSeq","NP_001333014.1","27922006","The combination of trans ganglioside binding and cis homodimerization explains how MAG maintains the myelin-axon spacing and provides a mechanism for MAG-mediated bi-directional signalling. Publication Status: Online-Only"
10858a14555,14558
> "Q3US41-1","RefSeq","NP_918944.2","30049844","Bleomycin (BLM) inhibited the expression of epithelial splicing regulatory protein 1 (ESRP1), resulting in enhanced alternative splicing of FGFR2 to the mesenchymal isoform IIIc. BLM-induced lung fibrosis was also associated with the activation of TGF-b/Smad signaling. Publication Status: Online-Only"
> "Q3US41-1","RefSeq","NP_918944.2","29324788","Study documented the expression of Esrp1 during gonadal development and in differentiating cells of the adult gonads: in mouse fetal gonads, Esrp1 mRNA was specifically detected in germ cells of either sex and absent from somatic gonadal cells. Esrp1 mRNA was present in a gonocyte-enriched cell fraction and in all germ cells examined in postnatal testis. Publication Status: Online-Only"
> "Q3US41-1","RefSeq","NP_918944.2","29107558","Implicate mutations in Epithelial Splicing-Regulatory Protein 1 as a cause of SNHL and demonstrate the complex interplay between alternative splicing"
> "Q3US41-1","RefSeq","NP_918944.2","19285943","Epithelial splicing regulatory proteins 1/2 (ESRP1/2) are epithelial cell-type-specific regulators of FGFR2 splicing."
10861a14562
> "Q91WU6-1","RefSeq","NP_598728.1","28057756","DHHC7 KO mice developed hyperglycemia and glucose intolerance, thereby confirming that DHHC7 represents the principal PAT for Glut4 and that this mechanism is essential for insulin-regulated glucose homeostasis."
10863a14565,14566
> "P59055-1","RefSeq","NP_848749.2","23076708","CpG methylation converses with histone modifications in an opposing sense of regulating Mbu-1 expression"
> "P59055-1","RefSeq","NP_848749.2","17433858","The mbu-1 gene was only expressed in the brain and spinal cord during the embryonic stages, and throughout all regions of the adult brain, showing higher levels in the hippocampus and hypothalamus"
10868,10869c14571,14577
< "Q8R5M8-1","RefSeq","NP_997558.2","12202822","SynCAM1 is expressed in brain and localized to pre- and postsynaptic sites of neurons.  SynCAM1 is a homophilic cell adhesion molecule that induces formation of presynaptic terminals by neurons."
< "Q8R5M8-1","RefSeq","NP_997558.2","12242005","The Tslc1 gene is mapped on mouse chromosome 9, a synteny of human chromosome 11q, and is composed of ten exons, the exon-intron junctions being highly conserved between human and mouse."
---
> "Q8BLA8-1","RefSeq","NP_808449.1","30974795","Expression and Activity of TRPA1 and TRPV1 in the Intervertebral Disc: Association with Inflammation and Matrix Remodeling. Publication Status: Online-Only"
> "Q8BLA8-1","RefSeq","NP_808449.1","30699406","TRPA1 mediates early events in allergic inflammation, but does not seem to affect allergic sensitization."
> "Q8BLA8-1","RefSeq","NP_808449.1","30353098","TRPA1 channels are involved in bladder mechanosensory. Publication Status: Online-Only"
> "Q8BLA8-1","RefSeq","NP_808449.1","15483558","Inhibition of TRPA1 protein expression in zebrafish and mouse inner ears inhibits receptor cell function [TRPA1]"
> "Q8BLA8-1","RefSeq","NP_808449.1","15046718","TRPA1 activation elicits a painful sensation and provide a potential molecular model for why noxious cold can paradoxically be perceived as burning pain."
> "Q8BLA8-1","RefSeq","NP_808449.1","12815418","Functional comparison with Drosophila protein homologue"
> "Q8BLA8-1","RefSeq","NP_808449.1","12654248","This protein was found only in dorsal root ganglia and responds to cold temperatures."
10870a14579
> "P97318-1","RefSeq","NP_796233.2","30139844","Deletion of Dab1 in endothelial cells leads to a reduced secretion of laminin-alpha4 and decreased activation of integrin-beta1 in glial cells, which in turn control neuronal migration and barrier properties of the neurovascular unit."
10871a14581,14589
> "Q8VC66-1","RefSeq","NP_620083.1","24356449","The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone."
> "Q8VC66-1","RefSeq","NP_620083.1","22027834","The results indicate that ADIP plays an essential role in PDGF-induced cell movement by interacting with afadin and Vav2 and regulating the activation of Rac."
> "Q8VC66-1","RefSeq","NP_620083.1","12446711","Localization at cell-cell adherens junctions"
> "Q60739-1","RefSeq","NP_033866.4","28523530","That BAG-1L over-expression protects against hypoxia/re-oxygenation injury, at least in part, by interacting with HSP70, and by accelerating the activation of PI3K/AKT pathways"
> "Q60739-1","RefSeq","NP_033866.4","28502705","These results provide evidence for an emerging role of BAG-1M in the regulation of BACE1 expression and AD pathogenesis and that targeting the BAG-1M-NF-kappaB complex may provide a mechanism for inhibiting Abeta production and plaque formation."
> "Q60739-1","RefSeq","NP_033866.4","27633857","These studies demonstrate for the first time the significance of BAG-1-mediated protein-protein interactions. Publication Status: Online-Only"
> "Q60739-1","RefSeq","NP_033866.4","9679980","Alternate protein isoforms arise through the use of a non-AUG (CUG) codon in addition to two downstream in-frame AUG codons."
> "Q60739-1","RefSeq","NP_033866.4","9396724","The longer p50 isoform is generated through use of an upstream, in-frame, non-AUG translation initiation codon."
> "Q60857-1","RefSeq","NP_034614.2","30745564","Study is the first demonstration of a quantitative in vivo evaluation of serotonin transporter (SERT) density in subregions of the mouse brain using [11C]DASB-PET. Publication Status: Online-Only"
10876,10879d14593
< "Q8BJ56-1","RefSeq","NP_001157161.1","29320510","Non-cardiac ATGL-mediated modulation of the cardiac lipidome may play an important role in the pathogenesis of chronic heart failure. Publication Status: Online-Only"
< "Q8BJ56-1","RefSeq","NP_001157161.1","16009485","Adipose triglyceride lipase (desnutrin) is downregulated by isoproterenol, TNFalpha, and insulin."
< "Q8BJ56-1","RefSeq","NP_001157161.1","15550674","Reported that adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis; ATGL and hormone-sensitive lipase (HSL) coordinately catabolize stored triglycerides in adipose tissue [ATGL]"
< "Q8BJ56-1","RefSeq","NP_001157161.1","15337759","Desnutrin may have a role in the pathophysiology of obesity"
10889a14604,14605
> "Q8BG26-1","RefSeq","NP_082464.2","22404429","Nesca functions as an adapter involved in neuronal vesicular transport"
> "Q8BG26-1","RefSeq","NP_082464.2","15024033","Data suggest that Nesca serves a novel, nuclear-dependent role in neurotrophin-dependent neurite outgrowth."
10897a14614
> "Q60952-1","RefSeq","NP_796191.2","25552934","CEP2 attenuates myoblast differentiation but does not affect proliferation. Publication Status: Online-Only"
10902a14620
> "Q8C6B2-1","RefSeq","NP_598396.2","22503686","These findings suggest that cGK-Ialpha interacts with and phosphorylates rhotekin, thereby contributing to neurite outgrowth regulation."
10904a14623,14630
> "A2CG49-1","RefSeq","NP_001157740.1","28319837","Kalirin reduction in APPswe/PSEN1dE9 mice significantly attenuated psychosis-associated behavior at 12 months of age without changing spatial memory performance."
> "A2CG49-1","RefSeq","NP_001157740.1","25865668","Kalirin-7 plays a prominent role in nociceptive sensitization via activity-dependent modulation of spinal synapses. Publication Status: Online-Only"
> "A2CG49-1","RefSeq","NP_001157740.1","19800004","These data demonstrate important roles for kalirin in the regulation of cortical structure, ultrastructure, and spine structural plasticity."
> "A2CG49-1","RefSeq","NP_001157740.1","19625617","Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes. Erratum:[Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16890. Photowala, Huzefa [added]]"
> "P01582-1","RefSeq","NP_034684.2","31030836","IL-1alpha is required for a downstream signaling cascade of innate immunity for efficient clearance of Brucella"
> "P01582-1","RefSeq","NP_034684.2","30305325","IL-1alpha and not IL-1beta is the critical mediator of sepsis mortality, likely because of paracrine actions within the tissue"
> "P01582-1","RefSeq","NP_034684.2","30354247","In mouse model of cerebral ischemia mannose binding lectin acts as an early trigger of platelet IL-1alpha release, which in turn favors MBL deposition on ischemic vessels promoting an endothelial pro-inflammatory phenotype."
> "P01582-1","RefSeq","NP_034684.2","29867931","The alarmin IL-1alpha released upon ozone-induced tissue damage and inflammation is mediated by MyD88 signaling in epithelial cells. Publication Status: Online-Only"
10908,10912c14634
< "Q6R0H7-1","RefSeq","NP_034439.2","30266511","Gsalpha signaling in osteocytes leads to osteopenia driven, at least in part, by increased secretion of sclerostin."
< "Q6R0H7-1","RefSeq","NP_034439.2","30142336","In mice that express activated KRAS in the pancreas, we found expression of GNAS(R201C) to cause development of more differentiated tumors, with gene expression pattern associated with the ductal phenotype."
< "Q6R0H7-1","RefSeq","NP_034439.2","15798190","Maternally expressed Nesp55 plays a role in controlling exploratory behavior."
< "Q6R0H7-1","RefSeq","NP_034439.2","15148396","Data report that the XL exon of Gsalpha is longer than presumed and contributes an additional 364 codons to XLalphas."
< "Q6R0H7-1","RefSeq","NP_034439.2","10097123","Gnas gene exhibits a complex imprinted pattern, giving rise to transcripts that are maternally, paternally, or biallelically expressed."
---
> "Q64221-1","RefSeq","NP_848892.1","26156403","Suggested that the expression levels of Lmo3 and/or Hen2 could determine the fate of stem cells by inhibiting Hes1 function during nervous system development and might be a trigger of aberrant neurogenesis in vivo"
10922a14645,14649
> "Q99PL8-1","RefSeq","NP_085033.2","28665968","Showed that acute neurodegeneration caused by thiamine deficiency is preventable in most parts, and prompt high-dose thiamine administration is critical for the treatment of THMD2. However, reduction of thiamine should be performed carefully to prevent recurrence after recovery of the disease Publication Status: Online-Only"
> "Q99PL8-1","RefSeq","NP_085033.2","22194418","Both mTHTR-1 and mTHTR-2 are involved in carrier-mediated thiamin uptake by pancreatic acinar cells."
> "Q99PL8-1","RefSeq","NP_085033.2","19879271","THTR-2 is required for normal uptake of thiamin in the intestine and can fulfill normal levels of uptake in conditions associated with THTR-1 dysfunction."
> "Q99PL8-1","RefSeq","NP_085033.2","19423748","Pancreatic beta cells and islets take up thiamine by a regulated THTR1/2-mediated process."
> "Q99PL8-1","RefSeq","NP_085033.2","16206251","Intestinal and renal thiamin uptake are developmentally regulated during early stages of life, mediated through mTHTR-1 and mTHTR-2, and suggest the possible involvement of transcriptional regulatory mechanism(s) in this regulation."
10930a14658,14668
> "Q9ESJ7-1","RefSeq","NP_075362.3","23630580","SIMPL functions as a TNFalpha-dependent p65 co-activator by facilitating the recruitment of MED1 to p65 containing transcriptional complexes to control the expression of a subset of TNFalpha-induced genes. Publication Status: Online-Only"
> "Q9ESJ7-1","RefSeq","NP_075362.3","20534545","IRAK1BP1 functions through its effects on NF-kappaB as a molecular switch to bias innate immune pathways toward the resolution of inflammation"
> "Q9ESJ7-1","RefSeq","NP_075362.3","19941935","Signals transduced through the tumor necrosis factor-alpha-tumor necrosis factor -receptor I-SIMPL(substrate that interacts with mouse pelle-like kinase) pathway support hematopoietic progenitor cell survival, growth and differentiation"
> "Q9ESJ7-1","RefSeq","NP_075362.3","18268037","IRAK1BP1 regulates transcription of a specific subset of Toll-like receptor responsive genes, producing an overall antiinflammatory profile"
> "Q9ESJ7-1","RefSeq","NP_075362.3","17233114","Hsp70/Hsc70 bind the intrinsically disordered amino-terminal region of SIMPL to stabilize the protein and thereby regulate its activity."
> "Q9ESJ7-1","RefSeq","NP_075362.3","15485901","TNF-alpha activation of NF-kappaB dependent-gene expression requires nuclear relocalization of p65 as well as nuclear relocalization of SIMPL, generating a TNF-alpha-specific induction of gene expression."
> "Q8CDG5-1","RefSeq","NP_084146.1","23400243","LRF has a role in the process of implantation in uteri and development of preimplantation embryos in mice"
> "Q8CDG5-1","RefSeq","NP_084146.1","23071095","Postulate that LRF plays a critical role in the attenuation of the HPA axis through repression of glucocorticoid stress signaling during parturition and the postpartum period"
> "Q9EPA7-1","RefSeq","NP_597679.1","29674119","We propose that the E257K allele is a weak hypomorphic allele that has significantly reduced penetrance in the homozygous state. In contrast, compound heterozygous Nmnat1(E257K/-) mice exhibit photoreceptor defects which are exacerbated upon exposure to light."
> "Q9EPA7-1","RefSeq","NP_597679.1","29175372","That increasing NMNAT1 levels can slow the progression of symptoms and neuropathological features of tauopathy"
> "Q9EPA7-1","RefSeq","NP_597679.1","27735788","Using steady-state and flux analysis of NAD(+) metabolites in healthy and injured mouse dorsal root ganglion axons, we find that rather than altering NAD(+) synthesis, NMNAT1 instead blocks the injury-induced, SARM1-dependent NAD(+) consumption that is central to axon degeneration. Publication Status: Online-Only"
10933a14672,14679
> "Q6NZN1-1","RefSeq","NP_001333730.1","25994039","These results indicated an elevated basal metabolic rate and lipid metabolic alteration of male Pprc1(+/-) mice on high-fat diet, suggesting the significant role of Pprc1 in controlling mitochondrial gene expression and energy metabolic processes"
> "Q6NZN1-1","RefSeq","NP_001333730.1","22411706","Homozygous deficient PPRC1 mice failed to form egg cylinders and died after implantation but before embryonic day 6.5, whereas mice heterozygous for PPRC1 were viable, fertile and indistinguishable from their wild-type littermates."
> "Q14BU0-1","RefSeq","NP_081030.1","29720262","Upper zone of growth plate and cartilage matrix associated protein (Ucma) physically interacted with a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) protein (ADAMTS5) and blocked its aggrecanase activity in chondrocyte cultures. Publication Status: Online-Only"
> "Q14BU0-1","RefSeq","NP_081030.1","29563538","Study using Ucma/GRP-/- and ApoE-/- mice showed for the first-time evidence of a direct interaction between Ucma/GRP and Bmp-2. These results demonstrate an important role of Ucma/GRP in regulating osteo/chondrogenic differentiation and phosphate-induced mineralisation of vascular smooth muscle cells. Publication Status: Online-Only"
> "Q14BU0-1","RefSeq","NP_081030.1","24867294","Data suggest that a novel splice variant of GRP is expressed in cartilage and other tissues (i.e. GRP-F7); GRP-F1 is predominant splice variant expressed in adult tissues."
> "Q14BU0-1","RefSeq","NP_081030.1","19819238","Four alternative splicing variants derived from the mouse Ucma/GRP gene in chondrocytes were identified and their expression and subcellular localization during chondrogenesis was determined."
> "Q14BU0-1","RefSeq","NP_081030.1","18156182","Ucma may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells"
> "Q14BU0-1","RefSeq","NP_081030.1","17707622","The present data strongly suggest an important function of Ucma in the early phase of chondrocyte differentiation."
10970a14717
> "Q9WUI0-1","RefSeq","NP_038757.1","12117810","Required for the morphogenesis of axial mesoderm, the heart and the gut during embryogenesis"
10974a14722,14725
> "Q8R1I2-1","RefSeq","NP_778177.1","31103358","These results establish a spinal gating mechanism for itch that requires sustained repetitive activity of presynaptic GRP neurons and postsynaptic GRP signaling to drive GRPR neuron output"
> "Q8R1I2-1","RefSeq","NP_778177.1","30135866","Study finds that the combinatorial expression of gastrin releasing peptide and Neurod6 defines midbrain dopaminergic subpopulations with unique features. Publication Status: Online-Only"
> "Q8R1I2-1","RefSeq","NP_778177.1","29133874","Study shows that itch deficits in mice lacking NMB or GRP are non-redundant and Nmb/Grp double KO (DKO) mice displayed additive deficits. Furthermore, both Nmb/Grp and Nmbr/Grpr DKO mice responded normally to a wide array of noxious stimuli. NMB and GRP may transmit discrete itch information and NMBR neurons are an integral part of neural circuits for itch in the spinal cord. Publication Status: Online-Only"
> "Q8R1I2-1","RefSeq","NP_778177.1","28733141","These data suggest that GRPR expression in fibroblast-like synoviocytes (FLS)and that exogenous GRP are able to activate FLS invasion. This effect occurs at least in part through the AKT activation. Therefore, understanding of the GRP/GRPR pathway could be relevant in the development of FLS-targeted therapy for Rheumatoid arthritis ."
10980,10981c14731,14740
< "Q5BL07-1","RefSeq","NP_001280735.1","15328346","Functions as a protein unfoldase in peroxisomal biogenesis, using its N-terminal putative adaptor-binding domain"
< "Q5BL07-1","RefSeq","NP_001280735.1","15502339","Crystal structure of pex1"
---
> "Q9D4H9-1","RefSeq","NP_083680.2","28045076","PHF14 expression was upregulated in fibrotic models in vivo and in vitro, and the TGF-beta/smad3/PHF14 pathway acted as a self-limiting mechanism in the TGF-beta-dominated renal pro-fibrotic process by suppressing PDGFR-alpha expression. Publication Status: Online-Only"
> "Q9D4H9-1","RefSeq","NP_083680.2","23688586","Results indicated that PHF14 might be an epigenetic regulator and play an important role in the development of multiple organs in mouse"
> "Q9D4H9-1","RefSeq","NP_083680.2","22730381","Phf14 acts as a negative regulator of PDGFRalpha expression in mesenchymal cells undergoing normal and abnormal proliferation, and is a potential target for new treatments of lung fibrosis."
> "Q91ZD4-1","RefSeq","NP_277044.1","30189017","We observed a striking additive genetic interaction between Grhl2 and Grhl3 gain-of-function alleles. moderate Grhl3 overexpression also interacted with the Vangl2Lp allele to cause SB, demonstrating genetic interaction with the planar cell polarity signalling pathway that is implicated in mouse and human neural tube defects."
> "Q9Z148-1","RefSeq","NP_671493.1","30455462","Epidermis-specific deletion of G9a histone methyltransferase (G9a) results in higher chromatin accessibility without major morphological alterations."
> "Q9Z148-1","RefSeq","NP_671493.1","29720423","G9a facilitates maintenance of cellular identity of CD8 T cells."
> "Q9Z148-1","RefSeq","NP_671493.1","29745895","The authors show that G9a accumulates typically at 4 to 8 cell stage to promote timely repression of a subset of 4 cell stage-specific genes. Loss of maternal inheritance of G9a disrupts the gene regulatory network resulting in developmental delay and destabilisation of inner cell mass lineages by the late blastocyst stage. Publication Status: Online-Only"
> "Q9Z148-1","RefSeq","NP_671493.1","29774081","G9a exerts oncogenic effects in colorectal cancer by increasing Plk1 expression.  G9a dimethylated p53 at lysine 373, which in turn increased Plk1 expression and promoted CRC cell growth. Publication Status: Online-Only"
> "Q9Z148-1","RefSeq","NP_671493.1","12586828","Expression of Snrpn, an imprinted gene regulated by the Prader-Willi syndrome imprinting center is biallelic in G9a -/- ES cells, indicating loss of imprinting, and demonstrating a role of G9a in CpG methylation of PWS-IC."
> "Q9Z148-1","RefSeq","NP_671493.1","12130538","Results indicate that euchromatic Histone H3 lysine 9 (H3-K9) methylation regulated by G9a is essential for early embryogenesis and is involved in the transcriptional repression of developmental genes."
10984a14744,14750
> "Q9JJN6-1","RefSeq","NP_075954.1","27521659","MiR-215-5p is a negative regulator of adipocyte differentiation through post-transcriptional regulation of FNDC3B and CTNNBIP1 during early adipogenesis"
> "Q9JJN6-1","RefSeq","NP_075954.1","25321480","MiR-29b plays a pivotal role in fetal mouse neurogenesis by regulating ICAT-mediated Wnt/beta-catenin signaling. Publication Status: Online-Only"
> "Q9JJN6-1","RefSeq","NP_075954.1","12036951","Overexpression of Icat induces G(2) arrest and cell death in tumor cell mutants for adenomatous polyposis coli, beta-catenin, or Axin."
> "Q9Z321-1","RefSeq","NP_035754.1","23912948","This study indicated a role for TOP3beta in mRNA metabolism and suggest that it is involved in neurodevelopmental disorders."
> "Q9Z321-1","RefSeq","NP_035754.1","18367668","Suggest an unanticipated role for Top3beta beyond DNA repair in the activation of cellular responses to DNA damage"
> "Q9Z321-1","RefSeq","NP_035754.1","17517607","Chromosomal abnormalities in top3beta(-/-) mice might lead to a persistent increase in apoptotic cells, which might in turn lead to the progression of autoimmunity"
> "Q9Z321-1","RefSeq","NP_035754.1","12591952","DNA topoisomerase III beta has a role in infertility and aneuploidy"
11009a14776,14779
> "Q6ZQF0-1","RefSeq","NP_795953.2","30528234","TopBP1 deficiency during spermatogenesis impairs the localization of proteins involved in early recombination at DNA double-strand break, results in meiotic chromosome defects and leads to infertility."
> "Q6ZQF0-1","RefSeq","NP_795953.2","29114052","DNA damage response protein TOPBP1 regulates X chromosome silencing in the mammalian germ line."
> "Q6ZQF0-1","RefSeq","NP_795953.2","25666521","Consistent with prior reports, TopBP1 co-localized in discrete nuclear foci and was in complex with papillomavirus E2 protein."
> "Q6ZQF0-1","RefSeq","NP_795953.2","14718568","ATR and TopBP1 monitor meiotic recombination and are required for activation of the meiotic recombination checkpoint"
11012a14783,14787
> "Q0VGU4-1","RefSeq","NP_001034474.1","30460640","Implicate VGF in the development of cerebellar granule cells via promoting MAPK signaling and motor function in the adult stage"
> "Q0VGU4-1","RefSeq","NP_001034474.1","30316917","Results indicate that the rapid onset antidepressant-like actions of ketamine require VGF to regulate TrkB/mTOR/BICC1 signaling and AMPA receptor GluA1 phosphorylation."
> "Q0VGU4-1","RefSeq","NP_001034474.1","29653412","Upregulation of VGF may be implicated in the pathophysiology of schizophrenia."
> "Q0VGU4-1","RefSeq","NP_001034474.1","28680036","Study demonstrates that VGF-overexpressing mice exhibit behavioral and morphological abnormalities that may be related to the mental illnesses such as schizophrenia and depression. These findings indicate that VGF may be implicated in the pathogenesis of several mental illnesses and in brain development. Erratum:[Sci Rep. 2018 Nov 20;8(1):17326. PMID: 30455452] Publication Status: Online-Only"
> "Q0VGU4-1","RefSeq","NP_001034474.1","16141392","Modulation of VGF levels and/or VGF signaling may consequently represent an alternative means to regulate circulating glucose levels and insulin sensitivity."
11039a14815,14817
> "P70444-1","RefSeq","NP_031570.2","30281024","These results identify a role for Bid in homeostatic mitochondrial cristae reorganization, that we link to human cardiac disease. Publication Status: Online-Only"
> "P70444-1","RefSeq","NP_031570.2","29720226","Bid promotes E3 ubiquitin ligase-mediated signaling downstream of TLR3 and TLR4 inducing a pro-inflammatory response. Publication Status: Online-Only"
> "P70444-1","RefSeq","NP_031570.2","29495595","We show that BID is an important regulator downstream of FAS in mouse neutrophils. Loss of BID significantly delays FASL-cell death and partially counteracts the switch from apoptosis to necroptosis when caspases are blocked. Publication Status: Online-Only"
11052a14831
> "P26618-1","RefSeq","NP_035188.2","27894125","Polyadenylation of a PDGFRalpha intron in resident stem cells attenuates muscle fibrosis"
11057a14837,14838
> "P62874-1","RefSeq","NP_032168.1","28615442","Data, including data from studies using transgenic/knockout mice, suggest that Ppp1ca and Gnb1 interact in quiescent platelets; then, Ppp1ca and Plcb3 interact during platelet aggregation; thus, Gnb1 enlists Ppp1ca to modulate G protein-coupled receptor signaling. (Ppp1ca = protein phosphatase 1, catalytic subunit alpha; Gnb1 = guanine nucleotide-binding protein, subunit beta-1; Plcb3 = phospholipase C, subunit beta-3)"
> "P62874-1","RefSeq","NP_032168.1","27074662","It was concluded that GIRK2, through its dual responsiveness to G protein beta-gamma and Na+, mediates a form of neuronal inhibition that is amplifiable in the setting of excess electrical activity. Publication Status: Online-Only"
11064,11066c14845,14850
< "Q3TB92-1","RefSeq","NP_001028607.1","30556363","Allergin-1 might play an inhibitory role in autoantibody production via upregulation of macrophage phagocytosis."
< "Q3TB92-1","RefSeq","NP_001028607.1","27932517","The results suggest that Allergin-1 on skin MCs suppresses TLR2-induced dermatitis."
< "Q3TB92-1","RefSeq","NP_001028607.1","24552759","It is a immunoglobulin-like receptor which regulates the activation of mast cell.(review) Review article"
---
> "Q64338-3","RefSeq","NP_035184.1","30469494","Cardiac Pde1C is a direct transcriptional target of PPARalpha. Publication Status: Online-Only"
> "Q64338-3","RefSeq","NP_035184.1","29860631","By whole-mount immunofluorescence on postnatal day 3 mouse cochlea, we show its expression in outer (OHC) and inner (IHC) hair cells cytosol co-localizing with Lamp-1 in lysosomes. Furthermore, we provide evidence that the variant alters the PDE1C hydrolytic activity for both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)."
> "P23188-1","RefSeq","NP_035176.1","30266770","For the immune regulatory pathway necessary for TGF-beta production by T cells, our results support a two-step model, composed of STAT6 and furin"
> "P23188-1","RefSeq","NP_035176.1","29723063","Upon meiosis onset, active furin/IGF-1 receptor relocates into the cytoplasm to activate (phosphorylate) Akt to promote meiosis. In summary, our finding suggests that Plac1, a protein that is crucial for placentation, is also essential for oocyte meiosis and fertilization."
> "P23188-1","RefSeq","NP_035176.1","29976768","Coronary artery disease-associated genetic variant increases FURIN expression, promoting monocyte/macrophage migration and proliferation while inhibiting apoptosis."
> "P23188-1","RefSeq","NP_035176.1","29359685","The results showed that a protein called Furin activates Dispatched by splitting it at a specific point. When the break-point on Dispatch was genetically modified, Furin could no longer cleave the protein. As a consequence, Dispatched did not reach the correct location within cells to help Hedgehog move away from signal-releasing cells. Publication Status: Online-Only"
11069a14854,14864
> "Q9JKX3-1","RefSeq","NP_056614.3","30209118","Deletion of bone marrow Tfr2 ameliorates anemia and iron overload in a murine model of transfusion-independent thalassemia. Erratum:[Blood. 2019 Jul 4;134(1):94. PMID: 31273007]"
> "Q9JKX3-1","RefSeq","NP_056614.3","28540293","These data confirm the role of Tfr2a in modulation of erythropoiesis and of Tfr2b in favoring iron availability for erythropoiesis"
> "Q9JKX3-1","RefSeq","NP_056614.3","27477597","Tfr2 is a key regulator of brain iron homeostasis and propose a role for Tfr2 alpha in the regulation of anxiety circuits. Publication Status: Online-Only"
> "Q9JKX3-1","RefSeq","NP_056614.3","27169626","Erythroid Tfr2 is essential for an appropriate erythropoietic response in iron-deficient anemia"
> "Q91WP0-1","RefSeq","NP_034897.1","28739878","This study shows that MASP-2 contributes to the development of collagen Ab-induced arthritis"
> "Q91WP0-1","RefSeq","NP_034897.1","28462915","It has been shown that key proteins in the lectin arm of this pathway, MASP1, MASP2 and C3, are expressed in the developing cortex and that neuronal migration is impaired in knockout and knockdown mice. Publication Status: Online-Only"
> "Q91WP0-1","RefSeq","NP_034897.1","27235854","We induced anti-myeloperoxidase vasculitis in mice and showed that neither MASP-2- nor properdin-deficient mice were protected, suggesting that alternative pathway activation does not require properdin or the lectin pathway."
> "Q91WP0-1","RefSeq","NP_034897.1","27577570","MASP-2 has an essential role in the mediation of cerebral ischemia-reperfusion injury. Publication Status: Online-Only"
> "Q91WP0-1","RefSeq","NP_034897.1","15826378","Recombinant protein of masp2 was made and purified."
> "Q91WP0-1","RefSeq","NP_034897.1","15672593","Highly conserved intron sequences. Restricted expression contrasts with the ubiquitous expression of neighboring genes."
> "Q8R0S9-1","RefSeq","NP_759010.1","20448048","OAT-PG is proposed to be involved in the local PGE(2) clearance and metabolism for the inactivation of prostaglandin signals in the kidney cortex."
11071a14867,14870
> "Q61468-1","RefSeq","NP_061345.1","28287406","Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.("
> "Q61468-1","RefSeq","NP_061345.1","27626699","Our findings show that Sulf-1 is an important tumor suppressor gene in hepatocellular carcinoma (HCC), and its over expression downregulates Msln and results in a decrease in HCC cell proliferation, migration, invasion, and lymphatic metastasis."
> "Q61468-1","RefSeq","NP_061345.1","26931187","Results show that mouse mesothelin is similar to human mesothelin. Its stable overexpression in a pancreatic cancer cell line did not increase cell proliferation, suggesting that mesothelin is not necessarily a tumor progression factor. Publication Status: Online-Only"
> "Q61468-1","RefSeq","NP_061345.1","14676194","Binding of membrane-bound mesothelin to ovarian cancer antigen CA125 mediates heterotypic cell adhesion"
11087,11089d14885
< "Q6ZQM0-1","RefSeq","NP_001158042.1","24114843","EGF, which signals through CRAF, and an activated BRAF mutant also activate PKC and stimulate cell migration through up-regulating RFFL expression."
< "Q6ZQM0-1","RefSeq","NP_001158042.1","19138581","CARP2 [Rififylin] deficiency does not alter induction of NF-kappaB by TNFalpha."
< "Q6ZQM0-1","RefSeq","NP_001158042.1","15229288","Data show that the the amino-terminal domain of rififylin is critical for its recruitment to recycling endocytic membranes and for the inhibition of recycling."
11093,11095c14889,14892
< "Q91XW8-1","RefSeq","NP_001264821.1","22902560","Study identifies a requirement of mouse Fkbp6 for biogenesis of Miwi2 piRNAs GeneRIF: Transposon silencing Secondary piRNA biogenesis Cochaperone: interaction with Hsp90"
< "Q91XW8-1","RefSeq","NP_001264821.1","18408354","Fundamental role of Fkbp6 in homologous chromosome synapsis during male meiosis"
< "Q91XW8-1","RefSeq","NP_001264821.1","12764197","Fkbp6 is a component of the synaptonemal complex essential for sex-specific fertility and for the fidelity of homologous chromosome pairing in meiosis"
---
> "Q9CQC2-1","RefSeq","NP_079745.1","21339507","Data suggest that the conditional expression of mPlrp2 and mClps is involved in the hydrolysis of retinyl esters in the mouse liver."
> "Q9CQC2-1","RefSeq","NP_079745.1","19622781","Colipase (-/-)mice develop diet-induced obesity, as do colipase (+/+) mice, and have normal responses to a two-macronutrient choice diet and to a switch from a high-fat to a low-fat diet"
> "F6R5P4-1","RefSeq","NP_035462.2","30277599","Basal expression of Ccl17 in hippocampal neurons was strongly enhanced by peripheral challenge with lipopolysaccharide (LPS). LPS-mediated induction of Ccl17 in the hippocampus was dependent on local tumor necrosis factor signaling, whereas upregulation of Ccl22 required granulocyte-macrophage colony-stimulating factorCCL17 deficiency resulted in a diminished microglia density under homeostatic and inflammatory conditions"
> "F6R5P4-1","RefSeq","NP_035462.2","29871928","IL4 induces CCL17 production by acting through IRF4 in human monocytes and murine macrophages."
11105a14903,14908
> "Q60604-1","RefSeq","NP_033158.2","29724913","IL1beta and TNFalpha enhance RANKL-dependent expression of adseverin, which contributes to fusion processes in osteoclastogenesis Publication Status: Online-Only"
> "Q60604-1","RefSeq","NP_033158.2","28389691","Indicate that in healthy, developing tissues, adseverin contributes to the regulation of osteoclast structure but not to bone metabolism in vivo"
> "Q60604-1","RefSeq","NP_033158.2","26642432","Adseverin knockdown also suppressed the RANKL-mediated induction of nuclear factor of activated T-cell c1 (NFATc1), which is a key transcription factor in osteoclastogenesis. Publication Status: Online-Only"
> "Q60604-1","RefSeq","NP_033158.2","25681458","Data indicate that adseverin (Ads) regulates actin cytoskeleton in osteoclasts."
> "Q60604-1","RefSeq","NP_033158.2","25275604","Ads is a RANKL induced early regulator of osteoclastogenesis with a potential role in pre-osteoclast differentiation and fusion. Publication Status: Online-Only"
> "Q60604-1","RefSeq","NP_033158.2","11883943","Adseverin induction is a specific gene regulatory effect by TCDD on thymocytes."
11111a14915
> "P70266-1","RefSeq","NP_032850.1","15331593","Data show that cardiac overexpression of kinase-deficient PFK-2 reduces cardiac glycolysis that produced negative consequences to the heart including hypertrophy, fibrosis, and reduced cardiomyocyte function."
11121a14926,14933
> "Q921F2-1","RefSeq","NP_663531.1","31047794","We demonstrate that cross-regulation between TDP-43 and Neat1 is essential for their efficient regulation of a broad network of genes and, therefore, of pluripotency and differentiation."
> "Q921F2-1","RefSeq","NP_663531.1","30273599","Cytoplasmic mislocalization of TDP-43 is associated with enteroviral infection related Amyotrophic lateral sclerosis."
> "Q921F2-1","RefSeq","NP_663531.1","30373824","Demonstrate that TDP-43 is indispensable for oligodendrocyte survival and myelination, and loss of TDP-43 in oligodendrocytes exerts no apparent toxicity on motor neurons."
> "Q921F2-1","RefSeq","NP_663531.1","30464263","TDP-43 is an essential protein for normal skeletal muscle formation that unexpectedly forms cytoplasmic, amyloid-like oligomeric assemblies, which we call myo-granules, during regeneration of skeletal muscle in mice and humans; myo-granules bind to mRNAs that encode sarcomeric proteins and are cleared as myofibres mature"
> "Q921F2-1","RefSeq","NP_663531.1","30130494","This study demonstrated here that muscle-dominant TDP-43 transgenic mice had lower body weights and increased serum levels of myogenic enzymes"
> "Q80VL1-1","RefSeq","NP_082583.1","30590800","We show that mitochondria-anchored TDRKH controls multiple steps of pachytene piRNA biogenesis in mice. TDRKH specifically recruits MIWI, but not MILI, to engage the piRNA pathway. It is required for the production of the entire MIWI-bound piRNA population and enables trimming of MILI-bound piRNAs."
> "Q80VL1-1","RefSeq","NP_082583.1","29118143","Unlike most other Tudor domains TDRD2 preferentially recognizes an unmethylated arginine-rich sequence from PIWIL1."
> "Q80VL1-1","RefSeq","NP_082583.1","23714778","Loss of Tdrkh is associated with impaired spermatogenesis."
11127a14940,14945
> "Q61200-1","RefSeq","NP_032777.3","24639499","Nxph1 plays an instructive role in synaptic short-term plasticity and the configuration with GABA receptors."
> "Q61200-1","RefSeq","NP_032777.3","21628410","Results demonstrate the presence and function of a regulated signaling axis in hematopoiesis centered on NRXN1alpha and its modulation by DAG1 and NXPH1"
> "Q61200-1","RefSeq","NP_032777.3","12141453","Study on the expression of NXPH1 in the developing and adult olfactory bulb"
> "Q8BH82-1","RefSeq","NP_848843.1","16818490","Results support the existence of an N-acyl phosphatidylethanolamine (NAPE)-phospholipase D-independent route for N-acyl ethanolamine (NAE) biosynthesis and suggest that Abh4 plays a role in this pathway by acting as a (lyso)NAPE-selective lipase."
> "Q8BH82-1","RefSeq","NP_848843.1","16605240","Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids."
> "Q8BH82-1","RefSeq","NP_848843.1","15760304","Results confirm that overexpressed NAPE-PLD is capable of forming NAEs, including anandamide, in living cells"
11132a14951,14953
> "Q3UIL6-1","RefSeq","NP_766331.1","29503187","Plekha7 overexpression impedes the intrinsic and counteracts the Insm-1 induced, neural progenitor cell delamination."
> "Q3UIL6-1","RefSeq","NP_766331.1","23990464","Results indicate that PLEKHA7 plays a cooperative role with nectin and afadin in the proper formation of Adherens junction (AJ) in epithelial cell."
> "Q3UIL6-1","RefSeq","NP_766331.1","20808826","PLEKHA7 is a cytoplasmic component of the epithelial adherens junction belt, distinct from ZO-1 and E-cadherin Publication Status: Online-Only"
11135a14957,14960
> "Q9QUH0-1","RefSeq","NP_444338.2","30598505","Results establish ROS-elicited glutathionylation and its modulation by Grx1 as pivotal regulatory mechanisms controlling alpha4 integrin affinity and neutrophil mobilization from the bone marrow under physiological conditions."
> "Q9QUH0-1","RefSeq","NP_444338.2","30682073","Reveal a novel mechanism by which Glrx controls both LPS- and IL-33-mediated NF-kappaB activation leading to IL-33 production Publication Status: Online-Only"
> "Q9QUH0-1","RefSeq","NP_444338.2","29916538","These results indicate that PEP1GLRX1 attenuates neuronal cell death resulting from oxidative stress in vitro and in vivo. Therefore, PEP1GLRX1 may exhibit a beneficial role in the treatment of neuronal disorders, including ischemic injury."
> "Q9QUH0-1","RefSeq","NP_444338.2","29138498","These findings indicate that Grx1 induction plays a key role in mediating the protective effect of laminar blood flow and suggest that Grx1 may be a potential therapeutic target for atherosclerosis. Publication Status: Online-Only"
11144,11148c14969,14970
< "Q8BKH7-1","RefSeq","NP_001277554.1","30571167","Sin1 is an amplifier of platelet alphaIIbbeta3-mediated outsidein signaling and a susceptible sensor of hypoxia/ROS signaling in ischemic environments after myocardial infarction, inducing microthrombosis."
< "Q8BKH7-1","RefSeq","NP_001277554.1","28692058","In colorectal cancer tissues, the Sin1 protein but not mRNA was significantly upregulated while Pdcd4 protein was downregulated, suggesting that loss of Pdcd4 might correlate with Sin1 protein level but not mRNA level in colorectal cancer."
< "Q8BKH7-1","RefSeq","NP_001277554.1","28174303","This study provides evidence that Sin1, a known element of the mammalian target of rapamycin complex 2 (mTORC2), is required for Interferon-gamma-induced phosphorylation and activation of AKT and that such activation mediates downstream regulation of mTORC1 and its effectors."
< "Q8BKH7-1","RefSeq","NP_001277554.1","17043309","Sin1 together with Rictor are key components of mTORC2 and play an essential role in Akt phosphorylation and signaling"
< "Q8BKH7-1","RefSeq","NP_001277554.1","16962653","Results reveal that the SIN1-rictor-mTOR function in Akt-Ser473 phosphorylation is required for TORC2 function in cell survival but is dispensable for TORC1 function."
---
> "Q91ZP3-1","RefSeq","NP_766538.2","30028636","Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle is associated with skeletal myopathy."
> "Q91ZP3-1","RefSeq","NP_766538.2","29765047","Fatty acids stimulate Tip60-dependent acetylation and endoplasmic reticulum translocation of phosphatidic acid phosphatase lipin 1 to generate diacylglycerol for triacylglycerols synthesis. Publication Status: Online-Only"
11154a14977,14982
> "O88745-1","RefSeq","NP_033162.1","16029203","Taken together, our results indicate that Scrg1 is associated with neurodegenerative processes in TSE, but is not directly linked to dysregulation of prion protein."
> "O88745-1","RefSeq","NP_033162.1","14622145","Scrg1 is associated with the secretory pathway of neuronal cells."
> "Q5HZJ0-1","RefSeq","NP_081075.3","30367465","Study in mouse lines with either a targeted deletion of Drosha or an inducible expression of human DROSHA carrying a Wilms tumor (WT)-specific E1147K mutation that acts in a dominant negative manner underscores the importance of a viable self-renewing progenitor pool for kidney development, but there was no evidence of WT formation through impaired DROSHA function."
> "Q5HZJ0-1","RefSeq","NP_081075.3","30054561","Administration of bovine milk exosomes failed to rescue Drosha homozygous knockout mice, presumably due to low bioavailability or lack of essential microRNAs Publication Status: Online-Only"
> "Q5HZJ0-1","RefSeq","NP_081075.3","29339534","Mice lacking Drosha in the vascular endothelium developed a vascular phenotype resembling hereditary hemorrhagic telangiectasia that included dilated and disorganized vasculature, arteriovenous fistulae, and hemorrhages. Publication Status: Online-Only"
> "Q5HZJ0-1","RefSeq","NP_081075.3","17060477","Dicer is required in a cell-autonomous fashion for the development of natural T reg cells in the thymus and for efficient induction of Foxp3 by transforming growth factor beta."
11174,11176c15002,15003
< "Q3UMB5-1","RefSeq","NP_001078909.1","29950492","C9ORF72 and SMCR8 have interdependent functions in suppressing autoimmunity as well as negatively regulating lysosomal exocytosis-processes of potential importance to amyotrophic lateral sclerosis."
< "Q3UMB5-1","RefSeq","NP_001078909.1","27875531","These results demonstrate that the C9orf72-SMCR8 protein complex functions in the regulation of metabolism and provide evidence that loss of C9orf72 function may contribute to the pathogenesis of relevant diseases Publication Status: Online-Only"
< "Q3UMB5-1","RefSeq","NP_001078909.1","27617292","We created Smcr8 knockout mice and found that Smcr8 mutant cells exhibit impaired autophagy induction, which is similarly observed in C9orf72 knockdown cells. Mechanistically, SMCR8/C9ORF72 interacts with the key autophagy initiation ULK1 complex and regulates expression and activity of ULK1 Publication Status: Online-Only"
---
> "P39655-1","RefSeq","NP_031466.2","30792307","These results indicate that Alox12 loss activates a compensatory increase in Alox15 that sensitizes mouse beta cells to oxidative stress."
> "P39655-1","RefSeq","NP_031466.2","27470510","12(S)-HETrE, a 12-lipoxygenase oxylipin of dihomo-gamma-linolenic acid, inhibits thrombosis via Galphas signaling in platelets."
11185a15013
> "Q3V1L4-1","RefSeq","NP_084086.3","28325731","The results on muscles from the NT5C knockout mice contradict previous findings where AMP levels and AMPK activity were shown to be modulated by NT5C enzymes."
11189a15018,15019
> "Q9JLV2-1","RefSeq","NP_062802.2","29704259","Hepatocyte TRUSS promotes pathological stimuli-induced non alcoholic fatty liver disease and metabolic disorders, through activation of NF-kappaB by promoting ubiquitination and degradation of IkappaBalpha"
> "Q9JLV2-1","RefSeq","NP_062802.2","14585990","Cloning and characterization of tumor necrosis factor receptor 1 (TNF-R1)-associated ubiquitous scaffolding and signaling protein (TRUSS)"
11195,11197d15024
< "Q8C5N3-1","RefSeq","NP_085037.2","28250049","These findings identify subtle but significant alterations in spliceosome structure and function, including dysregulated Cajal bodies and CWC22 overexpression, in diabetic sensory neurons that offer new ideas regarding diabetic sensory neurodegeneration in polyneuropathy."
< "Q8C5N3-1","RefSeq","NP_085037.2","27371833","Authors have reconstructed the origin and history of a 127-kbp segmental duplication, R2d, in the house mouse (Mus musculus). R2d contains a single protein-coding gene, Cwc22 De novo assembly of both the ancestral (R2d1) and the derived (R2d2) copies reveals that they have been subject to nonallelic gene conversion events spanning tens of kilobases."
< "Q8C5N3-1","RefSeq","NP_085037.2","26149421","Study showed major differences in gene copy number in natural populations. CWC22, SFI1, and HJURP are highly conserved genes with the most copy-number variation. They all exhibit population-specific expansion patterns, perhaps for local adaptations."
11212,11215d15038
< "P23708-1","RefSeq","NP_001334330.1","31296853","Through genome-wide studies in mouse embryonic stem cells study finds that NF-Y is essential for the maintenance of the nucleosome-depleted region at gene promoters. Depletion of the NF-YA protein leads to the accumulation of ectopic nucleosomes over the transcription start site, reducing promoter accessibility. Publication Status: Online-Only"
< "P23708-1","RefSeq","NP_001334330.1","29530977","The results reveal a previously unrecognized physiological function of NFYA in controlling glucose metabolism by up-regulating the gluconeogenic genes Pck1 and G6pc."
< "P23708-1","RefSeq","NP_001334330.1","28281280","Data show that nuclear factor Y (NF-Y) binds to the inverted CCAAT element (ICE) in the Fatty acid synthase (Fasn) promoter specifically in refeeding states."
< "P23708-1","RefSeq","NP_001334330.1","27837431","Findings may point to a possible role of NF-YA in stress conditions that occur in chronic obesity, ER stress might be involved in the pathogenesis of obesity through NF-YA depletion."
11218,11221d15040
< "Q8BG87-1","RefSeq","NP_898961.2","31043609","Study in mice lacking Tet2 and Tet3 in T-reg cells indicate that Tet2 and Tet3 are guardians of T-reg cell stability and immune homeostasis. Publication Status: Online-Only"
< "Q8BG87-1","RefSeq","NP_898961.2","30979904","A non-catalytic action of TET3 is essentially required for the maintenance of the neural stem cell (NSC) pool in the adult subventricular zone niche by preventing premature differentiation of NSCs into non-neurogenic astrocytes Publication Status: Online-Only"
< "Q8BG87-1","RefSeq","NP_898961.2","30575719","MiR-150 target that regulates monocyte subsets Publication Status: Online-Only"
< "Q8BG87-1","RefSeq","NP_898961.2","20639862","All three mouse Tet proteins (Tet1, Tet2 and Tet3) can also catalyse conversion of 5-methylcytosine of DNA to 5-hydroxymethylcytosine"
11226,11228c15045,15050
< "Q8BWG8-1","RefSeq","NP_796205.1","30216111","These results suggest that beta-arr1 promotes liver fibrosis via autophagy-mediated Snail signaling, and beta-arr1 may be a therapeutic target for liver fibrosis."
< "Q8BWG8-1","RefSeq","NP_796205.1","30144357","In our study, we demonstrated here that beta-arr1 plays a crucial protective role in AP via repression of NF-_x04A1;Bp65 activation."
< "Q8BWG8-1","RefSeq","NP_796205.1","30591079","Beta-arrestin 1 mediates beta2-adrenergic receptor-mediated skeletal muscle growth and strength. Publication Status: Online-Only"
---
> "O88554-1","RefSeq","NP_033762.1","30077797","Results provide evidence for a new role for PARP2 as a lipid-modulated regulator of lipid metabolism."
> "O88554-1","RefSeq","NP_033762.1","30104678","PARP2 is preferentially activated by poly(ADP-ribose) (PAR) and subsequently catalyzes branched PAR chain synthesis. Publication Status: Online-Only"
> "O88554-1","RefSeq","NP_033762.1","29361132","PARP2 can PARylate and mono(ADP-ribosyl)ate (MARylate), respectively, 5'- and 3'-terminal phosphate residues at double- and single-strand break termini of a DNA molecule containing multiple strand breaks."
> "O88554-1","RefSeq","NP_033762.1","28751426","PARP2 protein deficiency protected mice from Concanavalin A -induced Liver Damage."
> "O88554-1","RefSeq","NP_033762.1","28181505","Peripheral T-cell number was not affected in single PARP-2-deficient mice.  Double-deficiency in PARP-1/PARP-2 in T-cells led to highly aggressive T-cell lymphomas. Publication Status: Online-Only"
> "O88554-1","RefSeq","NP_033762.1","12065591","Caspase-8 not only triggers and amplifies the apoptotic process at cytoplasmic sites but can also act as an executioner at nuclear levels where it cleaves PARP-2"
11237a15060
> "P09174-1","RefSeq","NP_036197.1","27268253","AIPL1-mediated production of folded PDE6C is markedly elevated in the presence of the inhibitory Pgamma-subunit of PDE6."
11239a15063,15064
> "G3X9J0-1","RefSeq","NP_001074497.1","28951961","To determine the impact of the truncated Sipa1l3 domains on eye development."
> "G3X9J0-1","RefSeq","NP_001074497.1","26231217","Abnormalities of SIPA1L3 contribute to lens and eye defects, and we identify a critical role for SIPA1L3 in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization."
11250a15076,15080
> "Q9JL26-1","RefSeq","NP_062653.2","28361956","FMNL1 is required for actin assembly on lipid droplets (LDs) in vitro and for NMIIa recruitment to LDs in cells. We propose a novel acto-myosin structure regulating lipid storage: FMNL1-dependent assembly of myosin II-functionalized actin filaments on LDs facilitates their dissociation, thereby affecting LD surface-to-volume ratio and enzyme accessibility to triglycerides. Publication Status: Online-Only"
> "Q9JL26-1","RefSeq","NP_062653.2","25447542","Depleting FMNL1, another Formin family member, resulted in reduced mDia1 expression, while RhoA inhibition did not alter mDia1 expression, which indicated that there was a FMNL1-mDia1-Profilin1 signaling pathway in mouse oocytes."
> "Q9JL26-1","RefSeq","NP_062653.2","26083584","In oocyte meiosis, FMNL1 is required for spindle organization and actin assembly."
> "Q9JL26-1","RefSeq","NP_062653.2","16556604","The bundling activities of FRL1 and mDia2, while producing phenotypically similar bundles, differ in mechanistic detail"
> "Q9JL26-1","RefSeq","NP_062653.2","16480715","Binding to interphase microtubules through exon-2-encoded domain of Fmn1 provides a novel mechanism by which Fmn1 isoform Ib could coordinate actin filaments and microtubules."
11258a15089
> "Q8CEK3-1","RefSeq","NP_898946.1","23097296","SPINKL's binding to ejaculated sperm in the uterus but not in the oviduct suggest that SPINKL serves as a sperm protector in the uterus by preventing premature capacitation."
11263a15095,15096
> "Q9Z1B5-1","RefSeq","NP_062372.2","28506992","Reduced MAD2 levels attenuate the apoptotic response to mis-segregating sex chromosomes and allow the formation of aneuploid sperm."
> "Q9Z1B5-1","RefSeq","NP_062372.2","29147457","Immunofluorescence staining for mitotic arrest deficient 2-like 1 and the protein kinase TTK, components of the spindle assembly checkpoint (SAC), suggested that this delay possibly involved SAC activation."
11286a15120,15121
> "P70188-1","RefSeq","NP_034759.1","16298999","Interaction of KIF3A/3B with KAP3 may be important for the proper progression of mitosis."
> "A9Q751-1","RefSeq","NP_001108546.1","18039845","Pcdp1 plays an important role in ciliary and flagellar biogenesis and motility sperm flagella and the cilia of respiratory epithelial cells and brain ependymal cells in both mice and humans."
11290a15126,15130
> "Q924I3-1","RefSeq","NP_663746.2","29386231","Atypical chemokine receptor 4 (ACKR4), is a identified a decoy receptor that binds and degrades CCR7 ligands CCL19/CCL21, as a regulator of early activated B cell differentiation."
> "Q924I3-1","RefSeq","NP_663746.2","28807994","A comprehensive model of CCL19 and CCL21 transport and gradient formation in the lymph nodes (LNs) was built; predicts that ACKR4 in LNs prevents CCL19/CCL21 accumulation in efferent lymph, but does not control intranodal gradients; instead, it attributes the disrupted interfollicular CCL21 gradients observed in Ackr4-deficient LNs to ACKR4 loss upstream"
> "Q924I3-1","RefSeq","NP_663746.2","20562329","CCX-CKR(-/-) have a 5-fold increase in the level of CCL21 protein in blood, and 2- to 3-fold increases in CCL19 and CCL21 in peripheral lymph nodes."
> "Q924I3-1","RefSeq","NP_663746.2","17485674","These observations indicate that the silent chemokine receptor CCX-CKR1, regulates homeostatic leukocyte migration by controlling the availability of chemokines in the extracellular space."
> "Q924I3-1","RefSeq","NP_663746.2","11981810","Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR.  (CCX-CKR)"
11296a15137,15141
> "P79621-1","RefSeq","NP_031601.1","30327417","Results uncover an NFAT5-regulated mechanism that maintains CIITA and MHCII expression in macrophages and thus modulates their T lymphocyte priming capacity."
> "P79621-1","RefSeq","NP_031601.1","30165873","This study provided evidence that CIITA is required for alpha-syn-induced MHCII expression and subsequent infiltration of peripheral immune cells in to the midbrain. Publication Status: Online-Only"
> "P79621-1","RefSeq","NP_031601.1","29238041","Low CIITA expression is associated with cancer."
> "P79621-1","RefSeq","NP_031601.1","28608405","Study found that CIITA exerts a highly restricted control over only the MHCII, H2-DO and H2-DM genes, in DC1 and DC2 cDC subsets, but not over other proposed targets"
> "Q8VEB3-1","RefSeq","NP_598586.1","26316022","C5orf30 is a previously unidentified negative regulator of tissue damage in rheumatoid arthritis, and this protein may act by modulating the autoaggressive phenotype that is characteristic of synovial fibroblasts"
11301a15147,15152
> "Q9D752-1","RefSeq","NP_082261.2","30046110","53BP1 pathway therefore comprises distinct double-strand break repair activities within chromatin and single-stranded DNA compartments, which explains both the immunological differences between 53bp1- and Rev7- deficient mice and the context specificity of the pathway"
> "Q9D752-1","RefSeq","NP_082261.2","28330620","This study demonstrates using super-resolution microscopy that numerous MAD2L2 microfoci are exclusively associated with euchromatin, similar to other factors of the DNA damage response. In the absence of MAD2L2 the amount of heterochromatin demarcated by H3K9me2 was significantly increased."
> "Q9D752-1","RefSeq","NP_082261.2","27488450","Skp2, a confirmed APC/C-CDH1 substrate and E-cadherin destroyer, was increased in TGF-beta1-treated proximal tubular epithelial cells, which could be blocked by MAD2B depletion."
> "Q9D752-1","RefSeq","NP_082261.2","26004212","Increased gonadotropins caused by the absence of functional oocytes and accumulation of DNA damage in cells caused by the lack of repair function could be responsible for the development and progression of ovarian tumors in the Rev7 mutant mouse."
> "Q9D752-1","RefSeq","NP_082261.2","25928475","The Mad2l2 (MAD2B, Rev7) gene product is not only required by PGCs, but also by pluripotent embryonic stem cells (ESCs), depending on the growth conditions."
> "Q9D752-1","RefSeq","NP_082261.2","22700975","Identification of the Rev7 binding surface of the Rev1 C-terminal domain"
11303,11304c15154,15156
< "Q8CIV3-1","RefSeq","NP_001077363.1","23677168","We finally isolate control and Enpp2-null dermal pipilla precursors and identify the expression and upregulation of LIPH, an alternative LPA-producing enzyme, suggesting that this gene could functionally compensate for the absence of Enpp2."
< "P43404-1","RefSeq","NP_001276694.1","29980684","Hypomorphic alleles of Zap70 or chemical inhibition of Zap70 catalysis leads to an increase of IFN-gamma-producing invariant natural killer T cells. Publication Status: Online-Only"
---
> "Q8CHI8-1","RefSeq","NP_775089.1","31142747","Ep400 absence causes peripheral neuropathy in mice, characterized by terminal differentiation defects in myelinating and non-myelinating Schwann cells and immune cell activation. Publication Status: Online-Only"
> "Q8CHI8-1","RefSeq","NP_775089.1","23064015","Incorporation of the histone variant H2A.Z at the promoter regions of PPARgamma target genes by p400/Brd8 is essential to allow fat cell differentiation"
> "Q8CHI8-1","RefSeq","NP_775089.1","20610385","P400/mDomino plays a key role in cellular proliferation by controlling the expression of cell-cycle-regulatory genes."
11311a15164,15168
> "Q8CEC0-1","RefSeq","NP_765982.2","18621024","Nup88 regulates the activity of NF-kappaB at the level of nucleocytoplasmic transport."
> "Q8CEC0-1","RefSeq","NP_765982.2","18606815","Nup88 is up-regulated in response to hypertonic stress and acts to retain TonEBP in the nucleus, activating transcription of critical osmoprotective genes."
> "Q9WVS0-1","RefSeq","NP_059508.2","30642977","The results identify a novel role for ICOS costimulation in imprinting the functional stability of Foxp3 that is required for the retention of full Treg cell function in the periphery."
> "Q9WVS0-1","RefSeq","NP_059508.2","29676593","ICOS differentially regulates effector T cells in secondary lymphoid organs and inflamed tissues."
> "Q9WVS0-1","RefSeq","NP_059508.2","30258434","Study has revealed a new intracellular mechanism in which Akt2 regulates ICOS expression via FoxO-1 and this signaling axis regulates the differentiation and function of NKT17 cells. This study provides a new linker between cell metabolism and function of iNKT cells. Publication Status: Online-Only"
11314,11317c15171
< "Q9Z0Z4-1","RefSeq","NP_001153099.1","30060949","Results suggest that ablation of hephaestin and ceruloplasmin could lead to severe systemic iron deficiency and local tissue iron overload, which disrupt the whole body iron homeostasis and impact on tissue functions"
< "Q9Z0Z4-1","RefSeq","NP_001153099.1","29883959","We thus used hephaestin (Heph) and ceruloplasmin (Cp) single-knockout mice and Heph/Cp double-knockout mice to investigate the roles of multicopper ferroxidases(MCF) in pancreatic iron homeostasis. We found that both HEPH and CP were expressed in the mouse pancreas, and that ablation of either MCF had limited effect on the pancreatic iron levels."
< "Q9Z0Z4-1","RefSeq","NP_001153099.1","30182051","HEPH and CP are not essential for intestinal iron absorption but are required for proper systemic iron distribution. Publication Status: Online-Only"
< "Q9Z0Z4-1","RefSeq","NP_001153099.1","29355933","Results show that both HEPH and CP are expressed in subcutaneous adipose tissue. Ablation of either MCF leads to a compensatory increase in the other, which contributes to the balance of iron status. However, ablation of both induces severe iron deposition in adipocytes and displays disordered carbohydrate metabolism characterized as type 2 diabetes."
---
> "Q61107-1","RefSeq","NP_061204.3","29128363","GBP3 over-expression promotes glioma growth in mice and is inversely correlated with patients survival rate."
11320a15175,15176
> "Q7TQ07-1","RefSeq","NP_862905.1","28570559","Inactivation of Poln in mouse embryonic fibroblasts did not alter cellular sensitivity to mitomycin C, cisplatin, or aldehydes.  Pol nu-defective mice had no alteration in DNA end-joining during immunoglobulin class-switching. Publication Status: Online-Only"
> "Q7TQ07-1","RefSeq","NP_862905.1","12794064","Identification as homolog to Mus308"
11321a15178
> "P62818-1","RefSeq","NP_035440.1","26065264","S100A3 is a new target gene of Kaiso in mouse skin"
11322a15180,15182
> "P07903-1","RefSeq","NP_031974.2","29860127","ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation (LPO) implicates LPO-induced DNA damage"
> "P07903-1","RefSeq","NP_031974.2","29747066","Chronic treatment of Ercc1(-/) mice with the mitochondrial-targeted radical scavenger XJB-5-131 attenuated oxidative DNA damage, senescence and age-related pathology."
> "P07903-1","RefSeq","NP_031974.2","28368372","ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes and that persistent DNA damage triggers chromatin changes that affect gene expression programs associated with NER disorders."
11327,11331c15187,15193
< "A2AP18-1","RefSeq","NP_001106831.1","23237262","The role of PLCeta2 in neuritogenesis was assessed during retinoic acid (RA)-induced Neuro2A cell differentiation"
< "A2AP18-1","RefSeq","NP_001106831.1","20060933","PLCeta2 exhibited a dynamic expression pattern during postnatal retinal development, strongly suggesting that this isozyme might be involved in the development and maturation of the retina."
< "A2AP18-1","RefSeq","NP_001106831.1","16107206","The molecular cloning and sequencing of phospholipase C eta2 are reported."
< "A2AP18-1","RefSeq","NP_001106831.1","15899900","PLC(eta)2 is a neuron-specific isozyme that may be important for the formation and/or maintenance of the neuronal network in the postnatal brain"
< "A2AP18-1","RefSeq","NP_001106831.1","15583837","Molecular cloning of PLC-eta1 and PLC-eta2."
---
> "P48381-1","RefSeq","NP_035395.2","16930429","These results demonstrate that regulatory factor X3 is necessary for ciliated ependymal cell differentiation in the mouse."
> "P48381-1","RefSeq","NP_035395.2","15121860","RFX3 is essential for the differentiation of nodal monocilia and hence for LR body axis determination."
> "Q9CQG9-1","RefSeq","NP_080709.1","29247399","Tmem100 is a potential regulator of kidney development by related to BMP signal transduction in the process of metanephric mesenchymal-cell-to-epithelial transition.BMP 7 is a key regulator of Tmem100-mediated cell proliferation in metanephric mesenchymal cells.There is a complicated regulation network among Tmem100, BMP7, and BMPR-II in mouse embryonic kidney-derived cells."
> "Q9CQG9-1","RefSeq","NP_080709.1","25538155","TMEM100 has essential functions for the maintenance of vascular integrity as well as the formation of blood vessels."
> "Q9CQG9-1","RefSeq","NP_080709.1","25640077","This study demonistrated that Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain in mice."
> "Q9CQG9-1","RefSeq","NP_080709.1","25318679","The Tmem100 deficiency causes EndMT defect during AVC cushion formation possibly via disturbance of multiple calcium-related signaling events."
> "Q9CQG9-1","RefSeq","NP_080709.1","20848592","Tmem100 was predominantly expressed in arterial endothelial cells of developing embryos."
11347a15210,15211
> "Q8BXA0-1","RefSeq","NP_848829.2","27225731","These results suggest that postsynaptic SALM5 promotes synapse development by trans-synaptically interacting with presynaptic LAR-RPTPs and is important for the regulation of excitatory synaptic strength. Publication Status: Online-Only"
> "Q8BXA0-1","RefSeq","NP_848829.2","27152329","We identified herpes virus entry mediator as a functional receptor that mediates SALM5's suppressive function. Our findings reveal a molecular link between the neuronal system and the immune system, and provide potential therapeutic targets for the control of CNS diseases. Publication Status: Online-Only"
11349a15214,15217
> "Q9D2Y4-1","RefSeq","NP_083281.1","30738250","MLKL deficiency prevents inflammatory cytokines production and MAPK signaling activation. Hence, MLKL deficiency inhibits DSS-induced colitis."
> "Q9D2Y4-1","RefSeq","NP_083281.1","23835476","Neither Mlkl nor Rip3 deficiency provided protection against polymicrobial sepsis-induced animal death in the study of septic shock induced by CLP."
> "Q9D2Y4-1","RefSeq","NP_083281.1","23612963","The importance of the RIP3-MLKL interaction in the formation of functional necrosomes and suggest that translocation of necrosomes to mitochondria-associated membranes is essential for necroptosis signaling."
> "Q9D2Y4-1","RefSeq","NP_083281.1","22265413","Findings implicate MLKL as a key mediator of necrosis signaling downstream of the kinase RIP3."
11350a15219,15224
> "P50247-1","RefSeq","NP_057870.3","29127188","These results indicate that epigenetically mediated inhibition of Ahcy expression may be a driving force in causing SAH elevation and subsequent downstream disturbances in transsulfuration and transmethylation pathways during the development and progression of nonalcoholic steatohepatitis."
> "P50247-1","RefSeq","NP_057870.3","26687445","H19 knockdown activates SAHH, leading to increased DNMT3B-mediated methylation of an lncRNA-encoding gene Nctc1 within the Igf2-H19-Nctc1 locus. Publication Status: Online-Only"
> "P50247-1","RefSeq","NP_057870.3","20938992","Ahcy was identified from coupling of methylation with gene expression data, shed light on the underlying mechanisms of cytosine demethylation under methyl-deficient conditions."
> "P50247-1","RefSeq","NP_057870.3","20208169","Report the crystallization of mouse SAHH in the presence of the reaction product adenosine. The crystals diffracted to at least 1.55 A degrees resolution and are suitable for X-ray structure analysis at high resolution."
> "Q9QXV9-1","RefSeq","NP_036026.1","30635790","Our findings indicate that Spry1 is an important regulator of cardiomyocyte viability during ischemia-reperfusion injury Publication Status: Online-Only"
> "Q9QXV9-1","RefSeq","NP_036026.1","30126987","Loss of Spry1/2 enhances the survival of effector CD8+ T cells and results in the formation of more protective memory cells. Deleting Spry1/2 in antigen-specific CD8+ T cells may have therapeutic potential for enhancing the survival and functionality of effector and memory CD8+ T cells in vivo."
11358a15233
> "Q8CHG5-1","RefSeq","NP_835166.3","27162139","New protein isoform encoded by KIAA0317, termed fibrosis-inducing E3 ligase 1 (FIEL1), which potently stimulates the TGFbeta signaling pathway through the site-specific ubiquitination of PIAS4."
11359a15235
> "Q8R184-1","RefSeq","NP_666239.1","17499476","Localization and preliminary characterization of human homologs"
11364a15241,15246
> "Q9Z1T6-2","RefSeq","NP_035216.2","30295876","Enlarged vacuole formation in PIKfyve-deficient cells was not rescued by Ca2+ or over expression of TRPML1. It is likely that the acidification and vacuolation arrest is bifurcating downstream of PIKfyve"
> "Q9Z1T6-2","RefSeq","NP_035216.2","29584722","These studies identify a novel role for PIKfyve in controlling the delivery of proteins from the endosomal compartment to the melanosome, a role that is distinct from the role of PIKfyve in the reformation of lysosomes from endolysosomes. Publication Status: Online-Only"
> "Q9Z1T6-2","RefSeq","NP_035216.2","28779020","This study shows that PIKfyve coordinates the neutrophil immune response through the activation of the Rac GTPase"
> "Q9Z1T6-2","RefSeq","NP_035216.2","28533230","Thus, PIKfyve plays a role in preventing excessive lung inflammation through regulating alveolar macrophage function."
> "Q9Z1T6-2","RefSeq","NP_035216.2","28396567","The authors provide evidence that inactivation of PIKfyve by the selective inhibitor STA suppresses excessive mitochondrial reactive oxygen species production and apoptosis through a SIRT3-dependent pathway in cardiomyoblasts."
> "Q3U381-1","RefSeq","NP_892041.2","21910974","AREBP is a key modulator of hepatic glucose production regulated by AMPK in vivo."
11370a15253
> "Q3V188-1","RefSeq","NP_032928.1","24344237","EndoU is a critical regulator of an RNA-dependent pathway controlling peripheral B cell survival and antigen responsiveness that may contribute to peripheral B cell tolerance."
11374,11376d15256
< "Q8R104-1","RefSeq","NP_001171275.1","31015456","Study provides evidence that neuronal networks in the hippocampus of mice adapt to intermittent food deprivation by up-regulating GABAergic inhibitory neurotransmission via a mechanism requiring SIRT3 and involving a reduction in mitochondrial oxidative stress. Publication Status: Online-Only"
< "Q8R104-1","RefSeq","NP_001171275.1","17923681","These results extend the recent finding of lysine acetylation of mitochondrial proteins and demonstrate that SIRT3 has evolved to control reversible lysine acetylation in this organelle."
< "Q8R104-1","RefSeq","NP_001171275.1","15653680","Results demonstrate that SIRT3 activates mitochondria and plays an important role in adaptive thermogenesis in brown adipose tissue. GeneRIF: Caloric restriction and cold exposure elevate SIRT3 expression in brown adipose to regulate thermogenesis through PGC-1alpha and UCP1."
11387a15268,15270
> "Q8BZT5-1","RefSeq","NP_780514.1","29461900","LRRC19 could be a potential therapeutic target for pressure ulcers."
> "Q8BZT5-1","RefSeq","NP_780514.1","26776522","LRRC19 deficiency impairs the gut immune system and host-microbiota interactions."
> "Q8BZT5-1","RefSeq","NP_780514.1","19679103","LRRC19 may play an important role in inducing innate immune responses in certain tissues such as the kidney."
11397a15281,15285
> "P0DMC4-1","RefSeq","NP_001284483.1","28890073","The ELABELA (ELA)-APJ signaling axis is only required for sinus venosus-derived progenitors."
> "P0DMC4-1","RefSeq","NP_001284483.1","28854362","Loss of Apela signaling impacts early Aplnr-expressing mesodermal populations."
> "P0DMC4-1","RefSeq","NP_001284483.1","28663440","Elabela but not Apelin knockout pregnant mice exhibit preeclampsia -like symptoms, including proteinuria and elevated blood pressure due to defective placental angiogenesis."
> "P0DMC4-1","RefSeq","NP_001284483.1","26611206","Conclude that apela is present in the adult heart, is upregulated in post-infarction cardiac remodeling, and increases cardiac contractility in an ERK1/2-dependent manner"
> "P0DMC4-1","RefSeq","NP_001284483.1","20153842","Ende was expressed dynamically and in specific populations of the definitive endoderm from E7.0 to E8.5."
11415a15304,15310
> "Q811C2-1","RefSeq","NP_778194.3","22753949","We demonstrated for the first time that triggering of TRPV1 induces autophagy in mouse thymocytes resulting in AMPK activation and increased Atg4C mRNA expression"
> "Q99NF2-1","RefSeq","NP_064672.2","26977770","BDNF application can rescue the morphological deficits in hippocampal pyramidal neurons devoid of Jacob. Taken together, the data suggest that the absence of Jacob in early development interrupts a positive feedback loop between BDNF signaling Publication Status: Online-Only"
> "Q99NF2-1","RefSeq","NP_064672.2","25731822","NELF knockout is associated with impaired pubertal development and subfertility."
> "Q99NF2-1","RefSeq","NP_064672.2","24656816","Findings strongly indicate that NELF is part of the PPARalpha-mediated transcription regulatory network that maintains metabolic homeostasis in cardiomyocytes."
> "Q99NF2-1","RefSeq","NP_064672.2","24316376","The nuclear and non-nuclear NELF variant transcripts and proteins were identified, explaining variable NELF cellular localization."
> "Q99NF2-1","RefSeq","NP_064672.2","24317321","Jacob operates as a mobile hub that docks NMDA receptor-derived signalosomes to nuclear target sites."
> "Q99NF2-1","RefSeq","NP_064672.2","19608740","Calpain-mediated clipping of the myristoylated N terminus of Jacob is required for its nuclear translocation after N-methyl-d-aspartate receptor activation"
11420a15316,15324
> "P97926-1","RefSeq","NP_001074616.1","30650536","Increased binding of active histone mark H3K9Ac at the Oxtr transcriptional start site (TSS) was observed in the hippocampus of maternal high fat diet male (p < 0.05), but not female, offspring. Publication Status: Online-Only"
> "P97926-1","RefSeq","NP_001074616.1","30545636","Oxytocin regulates colonic motility via oxytocin receptor in myenteric plexus."
> "P97926-1","RefSeq","NP_001074616.1","30106994","This study suggests that Peg3 may function as a direct transcriptional regulator for Oxtr expression that acts to moderate the milk letdown process. Publication Status: Online-Only"
> "Q9Z202-1","RefSeq","NP_034782.1","30535636","Data suggest that the Cd94(LocA)/NKG2A receptor (NKG2A) heterodimeric receptor is widely expressed among M. musculus subspecies musculus."
> "Q9Z202-1","RefSeq","NP_034782.1","28474506","Liver cNK cells' hyporesponsiveness to stimulation through activating receptors is independent of IL-10, but correlates with decreased NKG2A expression compared to trNK cells."
> "Q9Z202-1","RefSeq","NP_034782.1","27435504","Here, we provide a new anti-inflammation mechanism about ANXA1 secreted from injured IECs, where ANXA1 can stimulate the expression of NKG2A in NK cells that affect the recruitment and activity of neutrophils necessary for pathology of colitis."
> "Q9Z202-1","RefSeq","NP_034782.1","26680205","NKG2A optimizes CD8(+) T cell responses during an acute poxvirus infection."
> "Q9Z202-1","RefSeq","NP_034782.1","25251060","Results demonstrate the immunoregulatory role of CD8(+) NKG2A expression in virus infection, which negatively regulates T cell effector functions and contributes to protection of tissue integrity during virus clearance. Publication Status: Online-Only"
> "Q69ZA1-1","RefSeq","NP_081394.1","24999027","The findings of this study suggest that Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression."
11426a15331,15336
> "P12025-1","RefSeq","NP_034914.1","29233575","Leukocyte domiciled midkine mediates increased plasma levels of VEGFA relevant for upregulation of endothelial nitric oxide synthase 1 and 3"
> "P23906-1","RefSeq","NP_032417.3","29563175","Our data suggest that IRF2 is an important regulator of the proinflammatory response in macrophages by controlling HIF-1alpha-dependent glycolytic gene expression and glycolysis."
> "P23906-1","RefSeq","NP_032417.3","28970238","Data show that HCFC2 is a critical component of the IRF1 and IRF2 transcriptional machinery that regulates Tlr3 gene expression."
> "P23906-1","RefSeq","NP_032417.3","27899441","Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion"
> "P23906-1","RefSeq","NP_032417.3","27277682","Mysm1 enhanced function of the IRF2 and IRF8 promoters, suggesting that Mysm1 governs the IRFs for hematopoietic stem cell homeostasis. Publication Status: Online-Only"
> "P23906-1","RefSeq","NP_032417.3","25251598","Chimeric IRF-2 binds with IRF-E motif and VREbeta but not with VREalpha1."
11435a15346,15350
> "Q8C437-1","RefSeq","NP_001156989.1","29953635","This study found that global loss of TRIP8b, a necessary subunit for proper HCN channel localization in pyramidal cells, led to active coping behavior in numerous assays specific to coping style."
> "Q8C437-1","RefSeq","NP_001156989.1","29168010","This study demonstrated that Hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels have important functions in controlling neuronal excitability and generating rhythmic oscillatory activity. The role of tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) in regulation of hyperpolarization-activated inward current, I h, in the thalamocortical system and its functional relevance"
> "Q8C437-1","RefSeq","NP_001156989.1","26459112","Study characterized the effects of deletion of the HCN channel auxiliary subunit TRIP8b in the mouse thalamus and cortex, focusing on electrophysiological changes and their role in promoting absence epilepsy"
> "Q8C437-1","RefSeq","NP_001156989.1","17393522","Both untreated and bile acid-fed PEX2(-/-) mice accumulated high levels of predominantly unconjugated bile acids in plasma because of altered expression of hepatocyte bile acid transporters."
> "Q8C437-1","RefSeq","NP_001156989.1","15564593","These data suggest a possible role for TRIP8b in regulating HCN channel density in the plasma membrane. [TRIP8b]"
11445a15361
> "Q8BK67-1","RefSeq","NP_776292.1","26661905","EGFR suppression of mitotic regulators including Rcc2 and Stathmin 1 are a mechanism for catagen induction in mouse skin"
11453,11455c15369,15372
< "Q9D3A9-1","RefSeq","NP_001103235.1","30177553","Ttyh1 enhances embryonic neural stem cell properties.Ttyh1 increases Notch target gene expression."
< "Q9D3A9-1","RefSeq","NP_001103235.1","28607172","In this report, we identify tweety-homolog 1 (Ttyh1), a membrane protein linked to neuronal development, as a potent driver of tumor microtube (TM)-mediated brain colonization by glioma cells."
< "Q9D3A9-1","RefSeq","NP_001103235.1","20568244","Ttyh1 plays an indispensable role during mitosis in early embryogenesis, possibly by maintaining Ca(2+) homeostasis in the ER."
---
> "P97797-1","RefSeq","NP_031573.2","30929259","This study shows that miR-378a modulates macrophage phagocytosis and differentiation through targeting CD47-SIRPalpha axis in atherosclerosis"
> "P97797-1","RefSeq","NP_031573.2","30770827","Data indicate that only signal regulatory protein alpha (SIRPalpha+) CD8(+) T cells actively proliferate and show cytolytic activity. Publication Status: Online-Only"
> "P97797-1","RefSeq","NP_031573.2","30602457","Microglia are effector cells of CD47-SIRPalpha antiphagocytic axis disruption against glioblastoma."
> "P97797-1","RefSeq","NP_031573.2","30308165","These results demonstrate that CD47-SIRPalpha signaling prevents excess microglial phagocytosis and show that molecular brakes can be regulated by activity to protect specific inputs"
11461a15379
> "Q80T69-1","RefSeq","NP_766272.2","14724137","Rosbin is associated with and is most likely phosphorylated by protein kinase A. We suggest that it plays an important role in transcriptional regulation in haploid germ cells."
11470a15389,15392
> "Q62407-1","RefSeq","NP_001166948.1","27729468","Acute loss of SPEG in hearts causes junctophilin-2 de-phosphorylation leading to heart failure."
> "Q62407-1","RefSeq","NP_001166948.1","19118250","Disruption of the striated preferentially expressed gene (Speg) locus leads to cardiac dysfunction and a phenotype consistent with dilated cardiomyopathy."
> "Q69ZW3-1","RefSeq","NP_694718.4","15247266","EHD1 and EHBP1, but not EHD2, are required for perinuclear localization of GLUT4 and reveal that loss of EHBP1 disrupts insulin-regulated GLUT4 recycling in cultured adipocytes."
> "Q69ZW3-1","RefSeq","NP_694718.4","14676205","EHBP1 is an EH domain binding protein that, along with EHD2, has a role in coupling endocytosis to the actin cytoskeleton [EHBP1]"
11472a15395,15397
> "Q62120-1","RefSeq","NP_032439.2","30671064","The loss of JAK1 in NK cells drives innate immune deficiency, whereas JAK2 deficiency leaves NK cell numbers and maturation unaltered. Publication Status: Online-Only"
> "Q62120-1","RefSeq","NP_032439.2","30662340","JAK2 activation regulates cPLA2 gene expression. Publication Status: Online-Only"
> "Q62120-1","RefSeq","NP_032439.2","30366920","These findings identify oncogenic cooperativity between Jak2V617F-driven MPN and Dnmt3a loss, leading to activation of HSPC enhancer-driven inflammatory signaling."
11474a15400,15401
> "Q2YDW7-1","RefSeq","NP_084517.2","29932923","KMT5a was identified as a target gene that was down-regulated in both mRNA and protein level when miR-127-3p mimics were introduced. miR-127-3p regulates the proliferation of myocytes through KMT5a."
> "Q2YDW7-1","RefSeq","NP_084517.2","28731465","Authors demonstrated that PR-Set7, an epigenetic regulator for H4K20me1 modification, was extensively expressed in the postnatal uteri, and its conditional deletion resulted in a complete lack of endometrial glands and infertility in mice."
11481a15409,15411
> "P38532-1","RefSeq","NP_032322.1","30316516","The results suggest that HSF1 and NRF2 suppress heme-induced and heat-induced HO-1 expression, respectively."
> "P38532-1","RefSeq","NP_032322.1","29941492","HSF1 phosphorylation at both Ser303 (S303) and Ser307 (S307) has been shown to repress HSF1 transcriptional activity under normal physiological growth conditions. Our results confirmed that loss of phosphorylation in HSF1(303A/307A) cells and tissues increases protein stability but also markedly sensitizes HSF1 activation under normal and heat- or nutrient-induced stress conditions. Publication Status: Online-Only"
> "P38532-1","RefSeq","NP_032322.1","24855652","After heat shock, HSF1gamma isoforms are exported from the nucleus more rapidly or degraded more quickly than HSF1alpha or HSF1beta"
11492a15423,15434
> "Q60737-1","RefSeq","NP_031814.2","29339659","These data suggest that Fcgamma receptor/reactive oxygen species/CK2alpha is a key inducer of NF-kappaB activation in airway epithelial cells in a murine model of asthma"
> "Q60737-1","RefSeq","NP_031814.2","29097596","Casein kinase 2 plays a central role in striatal physiology and in severity of l-DOPA-induced dyskinesia."
> "Q60737-1","RefSeq","NP_031814.2","28939766","Data (including data from studies using knockout mice) suggest that Brg1 is phosphorylated by casein kinase 2 (Ck2; Ck2alpha1 and Ck2alpha-prime are catalytic subunits) in proliferating skeletal myoblasts; Brg1 is catalytic subunit of SWI/SNF chromatin-remodeling enzymes; Ck2-mediated phosphorylation of Brg1 appears to regulate myoblast proliferation. (Brg1 = Brahma-related gene 1 protein)"
> "Q6EAL8-1","RefSeq","NP_083870.1","30659825","Beta2-microglobulin and interleukin-31 are involved in itching associated with CRF-induced pruritus."
> "Q6EAL8-1","RefSeq","NP_083870.1","30301503","The serum levels of IL-33 and IL-31 were significantly up-regulated in both AR and allergic asthma patients compared with normal individuals. Publication Status: Online-Only"
> "Q6EAL8-1","RefSeq","NP_083870.1","29796691","Atopic dermatitis linked cytokine interleukin-31 induced itch is mediated via a NPPB pathway."
> "Q6EAL8-1","RefSeq","NP_083870.1","29477033","IL-31 increased the concentration of intracellular Ca(2+) ions in mouse keratinocytes."
> "Q6EAL8-1","RefSeq","NP_083870.1","29366565","The available data show that IL-31 is strongly linked with chronic pruritic skin disorders, such as atopic eczema, and represents a novel target for directed drug therapy. Review article"
> "Q6EAL8-1","RefSeq","NP_083870.1","19414760","These data provide the first evidence of a function for IL-31-IL-31R interactions in limiting the magnitude of type 2 inflammatory responses within the intestine."
> "Q6EAL8-1","RefSeq","NP_083870.1","19054054","-31 antibody reduces scratching behaviour in an atopic dermatitis-like murine model during the onset of clinical skin manifestations"
> "Q6EAL8-1","RefSeq","NP_083870.1","17353366","IL-31 interaction with IL-31 receptor (IL-31R) is identified in an acute model of T helper cell type 2 inflammation in the lung."
> "Q6EAL8-1","RefSeq","NP_083870.1","15184896","IL-31 may be involved in promoting the dermatitis and epithelial responses that characterize allergic and non-allergic diseases Erratum:[Nat Immunol. 2005 Jan;6(1):114]"
11495a15438,15441
> "Q8CGA0-1","RefSeq","NP_789803.1","29054677","Ppm1f is involved in stress- and trauma-related manifestation of anxiety and depression."
> "Q8CGA0-1","RefSeq","NP_789803.1","26386307","C-terminal cytoplasmic fragment of PcdhgC5 acts as a scaffold for CaMKP and CaMKI to regulate CaMKP activity."
> "Q8CGA0-1","RefSeq","NP_789803.1","20016286","The POPX2 phosphatase regulates cancer cell motility and invasiveness."
> "Q8CGA0-1","RefSeq","NP_789803.1","18230650","The binding of POPX2 (PPM1F) to mDia1 or to an mDia-containing complex greatly decreases the ability of mDia1 to activate transcription from the serum response element (SRE)."
11505,11508c15451,15460
< "Q3TDN0-1","RefSeq","NP_001265147.1","29359685","The results showed that a protein called Furin activates Dispatched by splitting it at a specific point. When the break-point on Dispatch was genetically modified, Furin could no longer cleave the protein. As a consequence, Dispatched did not reach the correct location within cells to help Hedgehog move away from signal-releasing cells. Publication Status: Online-Only"
< "Q3TDN0-1","RefSeq","NP_001265147.1","18395198","Disp1 regulates growth of mammalian long bones through the control of Indian hedgehog distribution."
< "Q3TDN0-1","RefSeq","NP_001265147.1","12421714","Disp is required for the movement of Hh protein from its sites of synthesis in mice"
< "Q3TDN0-1","RefSeq","NP_001265147.1","12372258","Shh signaling is required within the notochord to maintain Shh expression and to prevent notochord degeneration. Disp1, unlike Smo, is not required for this juxtacrine signaling by Shh."
---
> "Q8VDK3-1","RefSeq","NP_034255.2","16229011","KRF is a novel transcription factor that is restricted to nuclear extracts isolated from keratinocytes and that binds to unique DNA sequences, which do not resemble any known consensus binding motif for transcription factors.[KRF]"
> "Q8VDK3-1","RefSeq","NP_034255.2","15829518","Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning."
> "Q8VDK3-1","RefSeq","NP_034255.2","15650748","Elf5 is essential for developmental processes in the embryo and in the mammary gland during pregnancy"
> "Q8VDK3-1","RefSeq","NP_034255.2","15655699","Demonstrated for the first time that Elf5 protein is localised to epithelium of exocrine glands including the kidney, mammary gland, stomach and the submandibular salivary gland"
> "Q9CQH0-1","RefSeq","NP_080294.1","30718277","These findings indicate that PDZK1IP1 interacts with Smad4 and thereby suppresses the TGF-beta signaling pathway."
> "Q9CQH0-1","RefSeq","NP_080294.1","18931049","Knockout mice for 3 members of the sodium-hydrogen regulatory factor (NHERF) family of PDZ adaptor proteins, NHERF1 (EBP50), NHERF2 (E3KARP) and NHERF3 (PDZK1), have helped to show that NHERF1 is essential for both normal and mutant CFTR function [review] Review article"
> "Q9CQH0-1","RefSeq","NP_080294.1","19710538","Systematic analysis of Pdzk1ip1 is reported."
> "Q9CQH0-1","RefSeq","NP_080294.1","16926447","The interaction between MAP17, NHERF3/4, and NaPiIIa in the trans-Golgi network could be an important intermediate or alternate path in the internalization of NaPiIIa"
> "Q9CQH0-1","RefSeq","NP_080294.1","12837682","MAP17 1) interacts with PDZK1 only, 2) associates with the NH2 terminus of NaPi-IIa within the PDZK1/NaPi-IIa/MAP17 complex, and 3) acts as an apical anchoring site for PDZK1."
> "Q9CQH0-1","RefSeq","NP_080294.1","12754212","Membrane associated protein 17 may be an endogenous regulator of cellular PDZ domain containing 1(PDZK1) levels by regulating PDZK1 turnover"
11511a15464,15465
> "Q6PAM0-1","RefSeq","NP_892042.2","29401588","The evidence indicates that AMPK is sufficient but not essential for the maintenance of DAPC expression in skeletal muscle, yet it is required for preserving extrasynaptic utrophin levels in slow oxidative muscles."
> "Q6PAM0-1","RefSeq","NP_892042.2","17709097","Results suggest that p38 MAPK is not a downstream component of AMPK-mediated signaling in skeletal muscle."
11525,11526c15479,15480
< "Q9WUH2-3","RefSeq","NP_001036042.1","29565736","That Smurf1 promotes Lhx9 ubiquitylation and is involved in testosterone production in Leydig cells directly"
< "Q9WUH2-3","RefSeq","NP_001036042.1","28456934","Lhx9 is a new molecular marker that defines a subset of amacrine cells and show that it is necessary for the development of the Nitric Oxide-Synthesizing Amacrine Cell subtype of amacrine cells."
---
> "Q6P5F9-1","RefSeq","NP_598775.2","29773601","Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3-mutated acute myeloid leukemias."
> "Q6P5F9-1","RefSeq","NP_598775.2","29028476","These results suggest a differential interaction between human Crm1 and mouse Crm1 and many lentiviral Rev proteins, which may partially explain the HIV replicative defect in mice."
11536a15491
> "B2RX70-1","RefSeq","NP_001074820.1","29935354","Some of the first data describing expression and alternative splicing of Cped1."
11552a15508,15512
> "Q3TEA8-1","RefSeq","NP_034600.2","27460150","Hp1bp3 and associated molecular networks are modulators of cognitive aging. GeneRIF: Loss of Hp1bp3 expression is associated with cognitive decline in both mice and humans."
> "Q3TEA8-1","RefSeq","NP_034600.2","27470444","Hp1bp3(-/-) females showed no deficits in behaviors often associated with impaired maternal care, including social behavior, depression, motor coordination and olfactory capability; and maintained unchanged anxiety-associated hallmarks such as cholinergic status and brain miRNA profiles. Results suggest a novel role for HP1BP3 in regulating maternal and anxiety-related behavior in mice"
> "Q3TEA8-1","RefSeq","NP_034600.2","26976970","Study identified Hp1bp3 overexpression as a potential novel marker for intrinsic 5-5-Fluorouracil resistance in colon cancer ."
> "Q3TEA8-1","RefSeq","NP_034600.2","26402843","HP1BP3 plays a key role in normal growth and bone development by regulating transcription of endocrine IGF-1 components. GeneRIF: HP1BP3 regulates hepatic expression of IGF-1 and its binding proteins, thus regulating the endocrine IGF-1 pathway."
> "Q3TEA8-1","RefSeq","NP_034600.2","25662603","The results suggest that HP1BP3 is a ubiquitous histone H1 like nuclear protein with distinct and non-redundant functions necessary for survival and growth."
11559a15520,15524
> "Q8R183-1","RefSeq","NP_599010.4","22469568","We concluded that pro-apoptotic effects on Th1 population through galectin-9-Tim-3 pathway and the up-regulation of Tim-2 on Th2 cells might be critical to Th2-biased response of host with schistosomiasis japonica."
> "Q8R183-1","RefSeq","NP_599010.4","21426565","TIM-2 signaling influences both proliferation and antibody production of B cells during the early phase of collagen-induced arthritis Publication Status: Online-Only"
> "Q8R183-1","RefSeq","NP_599010.4","21886823","TIM-2 can function as an iron uptake pathway."
> "Q8R183-1","RefSeq","NP_599010.4","17015678","Expression of TIM-2 significantly impairs the induction of NFAT and AP-1 transcriptional reporters"
> "Q8R183-1","RefSeq","NP_599010.4","16203866","TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis."
11575,11576c15540,15542
< "Q8CI08-1","RefSeq","NP_001106894.1","23077057","SLAIN2 is expressed throughout development and is highly enriched in brain."
< "Q8CI08-1","RefSeq","NP_001106894.1","21646404","Results identify SLAIN2 as a key component of microtubule plus end interaction networks."
---
> "Q3UV66-1","RefSeq","NP_035540.2","27427984","SLFN4 marks a GLI1-dependent population of myeloid-derived suppressor cells that predict a shift in the gastric mucosa to a metaplastic phenotype"
> "Q3UV66-1","RefSeq","NP_035540.2","24089532","Several mouse Slfn genes are up-regulated in response to IFN treatment of mouse melanoma and renal cell carcinoma cells, including Slfn1, Slfn2, Slfn4, Slfn5, and Slfn8."
> "Q3UV66-1","RefSeq","NP_035540.2","21249125","Slfn4 mRNA levels were up-regulated during macrophage activation but down-regulated during differentiation. Constitutive Slfn4 expression in the myeloid lineage in vivo perturbs myelopoiesis Publication Status: Online-Only"
11597a15564,15577
> "Q80XU3-1","RefSeq","NP_780503.2","28412246","This study demonstrates that depletion of NUCKS enhances the therapeutic efficacy of Bone marrow-derived mesenchymal stem cells for myocardial infarction via regulating the secretion of VEGFa."
> "Q80XU3-1","RefSeq","NP_780503.2","28106169","Study describes the role of NUCKS in corneal wound healing, inflammation and angiogenesis and links NUCKS to the activation of NF-kappa B and modulation of various cytokines. Publication Status: Online-Only"
> "Q80XU3-1","RefSeq","NP_780503.2","27542204","In the context of Trp53 deficiency, wild type levels of Nucks1 are required to suppress radiation-induced thymic lymphoma, likely through the role of the NUCKS1 protein in the DNA damage response"
> "Q80XU3-1","RefSeq","NP_780503.2","26205492","Hypothalamic NUCKS plays an essential role in regulating glucose homoeostasis and insulin signaling."
> "Q80XU3-1","RefSeq","NP_780503.2","24931609","NUCKS is a physiological regulator of energy homeostasis and glucose metabolism that works by regulating chromatin accessibility and RNA polymerase II recruitment to the promoters of IR and other insulin pathway modulators."
> "Q80UW2-1","RefSeq","NP_789818.1","27932386","F-box only protein 2 (FBXO2), a substrate recognition component of the Skp1-Cul1-F-box protein (SCF) E3 ubiquitin ligase complex, was upregulated in livers of obese mice. Furthermore, using a protein purification approach combined with high-performance liquid chromatography/tandem mass spectrometry, we carried out a system-wide screening of FBXO2 substrates, in which the insulin receptor (IR) was identified as a substrate"
> "Q80UW2-1","RefSeq","NP_789818.1","26295339","FBG1 degrades A1AT-Z through a Beclin1-dependent arm of autophagy. Publication Status: Online-Only"
> "Q80UW2-1","RefSeq","NP_789818.1","25878288","The results of this study suggested that Fbxo2 controls the abundance and localization of specific NMDAR subunits in the brain and may influence synapse formation and maintenance."
> "Q80UW2-1","RefSeq","NP_789818.1","15809437","When expressed in hippocampal neurons, the Fbx2 dominant-negative mutant augmented NR1 subunit levels and NMDA receptor-mediated currents in an activity-dependent fashion"
> "Q9JIA7-1","RefSeq","NP_975009.1","30077738","Sphk2 gene silencing induced by nanoparticles in hepatocellular carcinoma (HCC) cells could reduce miRNA-21 sorting into exosomes, contributing to the inhibition of tumor cell migration and tumorigenic function of exosomes to normal liver cells. In xenograft mouse model, Sphk2 siRNA loaded nanoparticles could significantly block tumor progression of malignancy HCC."
> "Q9JIA7-1","RefSeq","NP_975009.1","29991026","These data demonstrate that SK-2 exerts an antiproliferative and apoptosis-sensitizing effect in renal mesangial cells which suggests that selective inhibitors of SK-2 may promote proliferation and reduce apoptosis"
> "Q9JIA7-1","RefSeq","NP_975009.1","12954646","A functional nuclear localization signal is mapped to the N-terminal region of SPHK2"
> "Q9JIA7-1","RefSeq","NP_975009.1","12835323","The apoptotic effect of SphK2 might be because of its putative BH3 domain"
> "Q9JIA7-1","RefSeq","NP_975009.1","12874225","SPHK2 associates with the interleukin (IL)-12 receptor beta 1 cytoplasmic region and appears to be involved in the positive modulation of IL-12 signaling, especially IL-12-induced interferon-gamma production."
11603a15584,15587
> "Q8K371-1","RefSeq","NP_062738.2","17397395","Data show that MUPP1 interacts with angiomotin (Amot), JEAP/Amot-like 1 and MASCOT/Amot-like 2, and that all the Amot/JEAP family proteins also interacted with Patj, a close relative of MUPP1."
> "Q14BT6-1","RefSeq","NP_001070892.1","22307328","A4gnt(-/-) mice show complete lack of alphaGlcNAc expression in gastric gland mucin"
> "Q14BT6-1","RefSeq","NP_001070892.1","19751437","This publication contains functional information for the human homolog of mouse A4gnt."
> "Q14BT6-1","RefSeq","NP_001070892.1","10430883","This publication contains functional information for the human homolog of mouse A4gnt."
11606c15590
< "Q61419-1","RefSeq","NP_001104580.1","29196263","These findings have the potential to significantly advance our understanding of how this enigmatic tumor-associated antigen is produced in humans, and also suggest a possible mechanism of action of anti-tumor antibodies that recognize hypoxia markers, such as 14F7."
---
> "Q80VP5-1","RefSeq","NP_082586.1","22821833","Determined the solution structure of the GGQ-containing domain (GGQ domain) of C12orf65 from mouse by NMR spectroscopy."
11609,11610c15593,15598
< "Q8CGF7-1","RefSeq","NP_001034563.1","21365688","The study examines the order of formation of two beta-hairpins, the folding mechanism of each individual beta-hairpin, and transition state ensemble of formin-binding protein 28, FBP28 WW domain."
< "Q8CGF7-1","RefSeq","NP_001034563.1","16784750","The first beta-turn is near native-like in the transition state for folding and unfolding. Only after the backbone hydrogen bonds are formed between beta1 and beta2 does a hydrogen bond form to stabilize the first beta-turn."
---
> "Q9EQZ6-1","RefSeq","NP_062662.1","30252533","Deletion of Epac1 and Epac2 decreases sodium-hydrogen exchanger type 3 expression in the proximal tubule, leading to polyuria and osmotic diuresis"
> "Q9EQZ6-1","RefSeq","NP_062662.1","30048476","Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice Publication Status: Online-Only"
> "Q9EQZ6-1","RefSeq","NP_062662.1","12401793","Piccolo serves as a Ca(2+) sensor in exocytosis in pancreatic beta-cells and the formation of a cAMP-GEFII.Rim2.Piccolo complex is important in cAMP-induced insulin secretion"
> "Q3UHC1-1","RefSeq","NP_001034175.1","27111087","C3G is required in cortical neurons for both the specification of an axon and the initiation of radial migration by forming a leading process. Publication Status: Online-Only"
> "Q3UHC1-1","RefSeq","NP_001034175.1","26133694","Results provide evidence that C3G plays an important role in myogenic differentiation by coordinating cell cycle exit, actin dynamics and survival signaling."
> "Q3UHC1-1","RefSeq","NP_001034175.1","11909944","Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development."
11617a15606,15608
> "B1ARD8-1","RefSeq","NP_853523.2","29528433","We demonstrated that Slfn8-/- mice were resistant to the development of EAE."
> "B1ARD8-1","RefSeq","NP_853523.2","24089532","Several mouse Slfn genes are up-regulated in response to IFN treatment of mouse melanoma and renal cell carcinoma cells, including Slfn1, Slfn2, Slfn4, Slfn5, and Slfn8."
> "B1ARD8-1","RefSeq","NP_853523.2","15351786","Functional participation of slfn8 in the regulatory networks governing T cell development and growth appears to be cell type specific"
11631a15623
> "Q9CY27-1","RefSeq","NP_598879.1","16341590","Results describe the sequence and distribution of mouse synaptic glycoprotein homolog 2."
11634a15627,15628
> "Q9CPV1-1","RefSeq","NP_079857.3","24827423","Ska1 over-expression promotes tumourigenesis"
> "Q9CPV1-1","RefSeq","NP_079857.3","22336914","The Ska1 subunit was only localized on spindle microtubules from the Pro-MI to MII stages in mouse oocyte meiosis and knockdown by Morpholino injection into mouse oocytes resulted in spindle movement defects and enlarged polar bodies."
11638a15633
> "B3F5L4-1","RefSeq","NP_001121618.1","18641307","Described two novel surface receptors, SCART1 and SCART2"
11639a15635,15637
> "Q9JJ00-1","RefSeq","NP_035766.2","28282470","PLSCR1 aggravates anaphylactic reactions by increasing Fc epsion RI-dependent mast cell degranulation. Publication Status: Online-Only"
> "Q9JJ00-1","RefSeq","NP_035766.2","28111081","Genetic knockdown of PLSCR1 activity reduces intracellular calcium dysregulation, prevents phosphatidylserine externalization, and enables months-long protection of vector-transduced, transgene-expressing cells from microglial phagocytosis."
> "Q9JJ00-1","RefSeq","NP_035766.2","26216936","Phospholipid scramblase 1 regulates phosphatidylserine exposure in response to oxygen stress, leading to beta2-glycoprotein I and IgM binding and lipid-mediated, inflammatory responses."
11653,11656c15651,15653
< "Q9WTP6-1","RefSeq","NP_001029138.1","24740601","In addition to AK1 and AK2, which we previously demonstrated are present in outer dense fibers and mitochondrial sheath of the mouse sperm tail, we show that another AK, AK8, is present in a third flagellar compartment, the axoneme."
< "Q9WTP6-1","RefSeq","NP_001029138.1","24548998","Results suggest that AK2 is an associated activator of DUSP26 and suppresses cell proliferation by FADD dephosphorylation, postulating AK2 as a negative regulator of tumour growth."
< "Q9WTP6-1","RefSeq","NP_001029138.1","20876536","Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response."
< "Q9WTP6-1","RefSeq","NP_001029138.1","20728450","Reduced Akt2 leads to up-regulation of Rab4a expression in cardiomyocytes in a cell-autonomous fashion that may involve activation of PPARalpha."
---
> "Q91W40-1","RefSeq","NP_666294.1","22561200","KLC3 plays a role during spermiogenesis in the development of the midpiece and in the normal function of spermatozoa"
> "Q8CHC8-1","RefSeq","NP_778193.1","18179478","The adnp2 may have an important function in brain by playing a role in cellular survival pathways."
> "Q8R4Z4-1","RefSeq","NP_036181.3","22028470","Data show that ETV3 (a member of the E twenty-six family of transcriptional regulators), was extensively phosphorylated on sites within canonical and noncanonical ERK motifs. Publication Status: Online-Only"
11657a15655
> "Q8R4D5-1","RefSeq","NP_599013.1","30755524","Fluorescence-activated cell sorting (FACS) and subsequent microarray analysis of sensory neurons activated at 4 degrees C identified an enriched repertoire of ion channels, which include the Trp channel Trpm8 and potassium channel Kcnk9, that are potentially required for cold sensing above freezing temperatures in mouse DRG neurons."
11660a15659
> "Q99JT2-1","RefSeq","NP_598490.1","25642822","Findings reveal a mechanism by which TRAF6 is regulated and highlight a role for MST4 in limiting inflammatory responses."
11661a15661
> "P98078-1","RefSeq","NP_075607.2","30275566","Putative causal genes were enriched for proximal tubule expression and endolysosomal function, where DAB2, an adaptor protein in the TGF-b pathway, formed a central node. Functional experiments confirmed that reducing Dab2 expression in renal tubules protected mice from Chronic kidney disease."
11676a15677,15678
> "Q3U1V8-1","RefSeq","NP_796369.2","18414056","There is extensive functional redundancy between MLK1 and MLK2, and the other member of the family, MLK3, none of which are required for survival in mouse."
> "Q3U1V8-1","RefSeq","NP_796369.2","18036521","These results show that the expression of nucleosomal SRF-dependent genes, including the SMC gene, is activated by MKL1 via activation of SRF and recruitment of the FACT complex."
11680a15683,15684
> "Q9R016-1","RefSeq","NP_035000.2","29146805","Six distinct NAIP5 domains contact multiple conserved regions of flagellin, prying NAIP5 into an open and active conformation."
> "Q9R016-1","RefSeq","NP_035000.2","27114610","These results provide definitive genetic evidence for the important physiological function of NAIPs in antibacterial defense and inflammatory damage-induced lethality in mice."
11683a15688,15692
> "Q9WTN0-1","RefSeq","NP_034412.1","29444209","Geranylgeranyl pyrophosphate synthase mediated protein geranylgeranylation plays an indispensable role in the ventricular chamber maturation and acts as a stage-specific signal to regulate the establishment of cardiac cytoarchitecture during mid-gestation."
> "Q9WTN0-1","RefSeq","NP_034412.1","28357594","The specific deletion of Ggps1, using the Collagen 2-CreER(T2) mice, will accelerate the fracture healing process by activating the Bmp2/Smad-dependent Runx2 pathway."
> "Q9WTN0-1","RefSeq","NP_034412.1","28072828","Depletion of GGPP in mouse oocytes impaired the proliferation of granulosa cells, primary-secondary follicle transition and female fertility. GGPP depletion inhibited Rho GTPase geranylgeranylation and its GTPase activity. Publication Status: Online-Only"
> "Q9WTN0-1","RefSeq","NP_034412.1","21224049","These results reveal a new EGR-1/GGPPS/MAPK signaling pathway that controls cigarette smoke-induced pulmonary inflammation."
> "Q9WTN0-1","RefSeq","NP_034412.1","16978613","GGPP is critical for the cell-to-cell contact-induced differentiation, in which the down-regulation of GGPPS might be involved."
11687a15697,15701
> "Q8CI85-1","RefSeq","NP_848483.3","25771146","P2Y2R-mediated expression of CAXII by VICs acidifies the extracellular space and promotes the regression of CAVS."
> "Q8CI85-1","RefSeq","NP_848483.3","23233153","During inner ear development, transcripts of four cytosolic isozymes (Car1, Car2, Car3, and Car13), two membrane-bound isozymes (Car12 and Car14), and two CA-related proteins (Car8 and Car11) were expressed at higher levels than other isozymes."
> "Q8CI85-1","RefSeq","NP_848483.3","20820888","Car4, Car6, and Car12 showed moderate expression levels in the mouse harderian gland."
> "Q8CI85-1","RefSeq","NP_848483.3","16719910","CA12 may regulate ion and pH homeostasis within the developing embryo. Publication Status: Online-Only"
> "Q8CI85-1","RefSeq","NP_848483.3","14983512","High expression in the kidney and colon suggests a role for carbonic anhydrase XII in the maintenance of body ion and pH homeostasis in the mouse."
11692a15707,15710
> "Q920R0-1","RefSeq","NP_666221.1","27439389","Two ALS-linked factors, SQSTM1 and ALS2, have distinct but additive protective roles against mutant SOD1-mediated toxicity by modulating neuronal proteostasis possibly through the autophagy-endolysosomal system."
> "Q920R0-1","RefSeq","NP_666221.1","26755825","By taking advantage of this CSMN reporter line of AlsinKO, authors reveal that apical dendrite degeneration is a common cellular pathology for CSMN that become diseased for different causes."
> "Q920R0-1","RefSeq","NP_666221.1","22982304","Alsin and spartin may interact each other physically."
> "Q920R0-1","RefSeq","NP_666221.1","21937428","Alsin and SOD1(G93A) proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicity."
11697a15716,15720
> "O09111-1","RefSeq","NP_062308.2","16962385","Study shows that the expression of Ndufb11, a gene encoding the mitochondrial protein NP15.6 is decreased in the course of neuronal differentiation."
> "P28843-1","RefSeq","NP_034204.1","30778250","Findings indicate interleukin 33 (IL-33)- and eosinophil-mediated tumor control, revealed when endogenous mechanisms of dipeptidylpeptidase 4 (DPP4) immunoregulation are inhibited."
> "P28843-1","RefSeq","NP_034204.1","30188745","The effects of sitagliptin, a DPP4 inhibitor in wide clinical use, on LPS-induced lung injury in mice."
> "P28843-1","RefSeq","NP_034204.1","30188931","Of the six biomarkers, only COMP and DPP4 showed high and SPP1 moderate correlation with the spinal muscular atrophy phenotype. PLS3 overexpression neither influenced the SMN level nor the six biomarkers, supporting the hypothesis that PLS3 acts as an independent protective modifier. Publication Status: Online-Only"
> "Q99P30-1","RefSeq","NP_077766.3","18799520","Data suggest that NUDT7alpha function is tightly linked to peroxisomal CoASH/acyl-CoA homeostasis."
11700a15724,15727
> "Q9ERL7-1","RefSeq","NP_071307.1","29339159","Gmfg has two separate binding sites on Arp2/3 complex with high (site 1) and low (site 2) affinity. X-ray crystallography revealed closely located positions of Gmfg in site 1. Molecular dynamics simulation allowed determining the binding pocket for Gmfg in site 2."
> "Q9ERL7-1","RefSeq","NP_071307.1","23893131","The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin."
> "Q9ERL7-1","RefSeq","NP_071307.1","23727094","GMF debranches filaments by a mechanism related to cofilin-mediated severing, but in which GMF has evolved to target molecular junctions between actin-related proteins in the Arp2/3 complex and actin subunits in the daughter filament of the branch."
> "Q9ERL7-1","RefSeq","NP_071307.1","16873721","GMFG is a novel factor in actin cytoskeleton reorganization and is expressed preferentially in microvascular endothelial and inflammatory cells in embryonic development."
11703a15731,15733
> "P48678-1","RefSeq","NP_062263.1","21327075","Lamin C2 as a 'natural lamin deletion mutant' that confers unique properties to the nuclear envelope which would be essential for dynamic telomere repositioning during meiotic prophase I"
> "Q9JLJ5-1","RefSeq","NP_062295.1","29401594","Elongation of VLCFAs (ELOVL)1 is primarily responsible for the production of saturated VLCFAs, whereas ELOVL1, ELOVL3, and ELOVL4 redundantly participate in the synthesis of monounsaturated VLCFAs."
> "Q9JLJ5-1","RefSeq","NP_062295.1","11891222","Elucidation of structure and regulation"
11705,11709c15735,15739
< "Q9Z1X4-1","RefSeq","NP_001036172.1","28487382","Data support a model in which NF45, NF90, and NF110 operate in feedback loops that enable them, through both overlapping and independent targets, to help balance the push and pull of pluripotency and differentiation cues."
< "Q9Z1X4-1","RefSeq","NP_001036172.1","26289635","Reduction in the expression of YBX1 and ILF3 controls the expression of pluripotency-related genes in ESCs, suggesting their roles in further regulation of the pluripotent state of ESCs."
< "Q9Z1X4-1","RefSeq","NP_001036172.1","25918244","NF90-NF45 complex induces centronuclear myopathy through increased dynamin 2 expression by an NF90-NF45-induced reduction of miR-133a expression in vivo."
< "Q9Z1X4-1","RefSeq","NP_001036172.1","11438536","Characterization of NFAR-1 and NFAR-2 splice forms in human sample"
< "Q9Z1X4-1","RefSeq","NP_001036172.1","7519613","Cloning of human NF90"
---
> "P04627-1","RefSeq","NP_033833.1","28743549","PKM1 interacts with A-Raf, an upstream regulator of the MEK/ERK pathway, and that this interaction contributes to MEK1 phosphorylation by A-Raf."
> "P04627-1","RefSeq","NP_033833.1","28073913","A- and B-Raf ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF protein stability."
> "P04627-1","RefSeq","NP_033833.1","27240957","A-Raf promotes osteoblasts differentiation in response to mechanical stress."
> "P04627-1","RefSeq","NP_033833.1","24843139","DA-Raf-dependent inhibition of the Ras-ERK signaling pathway in alveolar epithelial 2 cells is required for alveolar formation via triggering MMP2 activation followed by myofibroblast differentiation."
> "P04627-1","RefSeq","NP_033833.1","24114843","Galpha12-ARAF-ERK pathway stimulates RFFL transcription through the transcription factor c-Myc."
11711a15742
> "P61237-1","RefSeq","NP_081151.2","21196260","Studies with mouse YPEL3, originally named small unstable apoptotic protein (SUAP), confirmed that the gene encodes a growth suppressive highly unstable protein.[review] Review article Publication Status: Online-Only"
11715a15747
> "Q9D787-1","RefSeq","NP_659203.1","22838834","Cpsf2,Ppil2, and SNAP-25 are the most promising targets for the NSm protein of the virus during an infection. Publication Status: Online-Only"
11720a15753
> "Q99KG7-1","RefSeq","NP_619587.3","27482051","VAMP7 mediates fusion of BLOC-1-dependent transport carriers with melanosomes, illuminate SNARE recycling from melanosomes as a critical BLOC-3-dependent step."
11750,11751d15782
< "Q8BKV0-1","RefSeq","NP_001239549.1","25138526","These results demonstrate that Spock3 plays an important role in the formation or maintenance of major neuronal structures in the brain."
< "Q8BKV0-1","RefSeq","NP_001239549.1","23418755","The expression of testican-3 in adult mice is restricted to the brain and located diffusely within the extracellular matrix."
11756,11758c15787
< "Q6PAM1-1","RefSeq","NP_001005506.2","26494466","The TXLNA may serve as an important feedback mechanism to modulate the magnitude of subsequent phagocytotic process of SCs in response to testicular injury."
< "Q6PAM1-1","RefSeq","NP_001005506.2","19663695","Analysis of a novel monoclonal antibody against interleukin-14alpha"
< "Q6PAM1-1","RefSeq","NP_001005506.2","19038581","Transgenic mice in which IL-14a expression was increased constitutively develop all the clinical and immunological features of primary Sjogren's disease in the same relative time frame as patients with primary Sjogren's disease"
---
> "Q8C398-1","RefSeq","NP_081664.2","21367863","Analysis of essential residues of PIG-W and Gwt1p and membrane topology of Gwt1p"
11777a15807,15809
> "Q91WT9-1","RefSeq","NP_835742.1","30110564","Functional studies revealed that NaHS administration improved muscle fatigability in CBS(+/-) mice. In conclusion, our work provides evidence that NaHS is beneficial in mitigating HHcy-mediated skeletal injury incited by oxidative/ER stress responses."
> "P04925-1","RefSeq","NP_035300.1","30275016","A high degree of order and stability of beta-sheet structure within the entire region between residues approximately 89 and 227 is a primary attribute of infectious PrP aggregates."
> "P04925-1","RefSeq","NP_035300.1","30359282","AMPA and NMDA receptors are differentially regulated by PrP(C), but share common modulation by copper ions. Publication Status: Online-Only"
11785a15818,15821
> "Q9QZX7-1","RefSeq","NP_038789.1","30391323","The studies findings demonstrate neuronal serine racemase association with DISC1 and its agglomerates, which can be modulated by d-Serine."
> "Q9QZX7-1","RefSeq","NP_038789.1","29913163","Serine racemase (SR) deficiency significantly prevented retinal ganglion cell (RGC) loss in diabetic mice. We conclude that D-serine is a critical factor in the degeneration of RGC in diabetic retinopathy (DR). Targeting SR expression or activity may be a strategy for ameliorating RGC loss in DR."
> "Q9QZX7-1","RefSeq","NP_038789.1","28892569","This study demonstrated that SR deficiency reduces retinal pigment epithelial cells response to laser-induced inflammatory stimuli, resulting in decreased production of a cascade of pro-angiogenic cytokines, including(.) NO and VEGF, and reduced macrophage recruitment, which contribute synergistically to attenuated angiogenesis."
> "Q9QZX7-1","RefSeq","NP_038789.1","12021263","Direct calcium binding results in activation in brain"
11792a15829,15830
> "P00342-1","RefSeq","NP_038608.1","30590713","The LDHA protein level was remarkably decreased in Ldhc-deficient sperm, indicating that LDHC is required for LDHA expression in the sperm."
> "P00342-1","RefSeq","NP_038608.1","27333189","Polymorphisms in the Ldhc gene control testis levels of S-2HG, and thereby epigenetics, across mammals"
11793a15832
> "Q7M6Y5-1","RefSeq","NP_861537.2","24240477","Deup1 governs deuterosome assembly to mediate large-scale de novo centriole biogenesis."
11796,11798c15835
< "Q9D7Q1-1","RefSeq","NP_001271454.1","29891554","These data show a detrimental role of chit1 in Klebsiella pneumoniae lung infections"
< "Q9D7Q1-1","RefSeq","NP_001271454.1","26079949","No significant differences were observed between experimental autoimmune encephalitis and control groups for CHIT-1 expression."
< "Q9D7Q1-1","RefSeq","NP_001271454.1","23685110","CHIT1 exerts protective effects against atherosclerosis by suppressing inflammatory responses and polarizing macrophages toward an M2 phenotype, and promoting lipid uptake and cholesterol efflux in macrophages."
---
> "Q5DP50-1","RefSeq","NP_001013627.1","16343427","Taken together, these results indicate that TESF-1 is a novel male germ cell-specific gene, and its protein product may function as a nuclear factor involved in the regulation of spermatogenesis."
11813a15851,15855
> "Q8CJ70-1","RefSeq","NP_001009940.1","29674474","IL-19 is an atheroprotective cytokine which decreases the abundance of HuR, leading to reduced inflammatory mRNA stability in Ldlr knockout mice."
> "Q8CJ70-1","RefSeq","NP_001009940.1","29386478","Data, including data from studies using knockout mice, suggest that interleukin-19 suppresses hapten-dependent skin inflammation in elicitation phase of contact hypersensitivity."
> "Q8CJ70-1","RefSeq","NP_001009940.1","28864472","Attenuated colitis in IL-19-deficient animals was associated with reduced numbers of IL-6-producing macrophages in the inflamed colonic lamina propria. Microbial-driven expression of IL-19 by intestinal macrophages may contribute to the pathogenesis of inflammatory bowel disease."
> "Q8CJ70-1","RefSeq","NP_001009940.1","27942772","IL-19 plays an anti-inflammatory role in the Th2-mediated colitis model."
> "Q8CJ70-1","RefSeq","NP_001009940.1","15557163","In a dust mite-induced murine model of asthma, the IL-19 level in asthmatic BALB/cJ mice is twice that of healthy control mice."
11834a15877,15879
> "Q8K4J0-1","RefSeq","NP_783614.1","25818648","ATM phosphorylates DNA-PKcs to recruit Artemis and promote end-processing."
> "Q8K4J0-1","RefSeq","NP_783614.1","12615897","Data show that Artemis appears to be required for a subset of nonhomologous DNA end joining reactions that require end processing [Artemis]."
> "Q8K4J0-1","RefSeq","NP_783614.1","12504013","Deficient mice have a phenotype similar to that of DNA-PKcs-deficient mice-including severe combined immunodeficiency associated with defects in opening and joining V(D)J coding hairpin ends and increased cellular ionizing radiation sensitivity (artemis)"
11841a15887,15889
> "Q8K1S7-1","RefSeq","NP_082692.1","31069116","Kremen2 antagonizes the apoptotic activity of Kremen1 Publication Status: Online-Only"
> "Q8K1S7-1","RefSeq","NP_082692.1","26929007","The dysregulated collagen metabolic process, ECM-receptor interaction and p53 signaling pathway may be responsible for impaired fracture healing of osteoporotic Krm2 transgenic mice."
> "Q8K1S7-1","RefSeq","NP_082692.1","12050670","Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling."
11843a15892,15893
> "Q9Z248-1","RefSeq","NP_848918.1","25451679","The two protein isoforms of AEBP2 may have opposite functions for the PcG target genes, and may play significant roles in cell migration during development."
> "Q9Z248-1","RefSeq","NP_848918.1","19293275","A large fraction of AEBP2's target loci also map closely to the known target loci of the Polycomb Repression Complex PRC2."
11846a15897
> "P19228-1","RefSeq","NP_031810.1","21789179","The role of the milk protein alpha-casein by inactivating the corresponding gene in mice, was analysed."
11849,11851d15899
< "Q9QYC0-1","RefSeq","NP_001019629.2","29032200","Sez6l2 is one of the auxiliary subunits of the AMPA receptor and acts as a scaffolding protein to link GluR1 to ADD. Furthermore, Sez6l2 overexpression upregulates ADD phosphorylation, whereas siRNA-mediated downregulation of Sez612 prevents ADD phosphorylation, suggesting that Sez6l2 modulates AMPA-ADD signal transduction."
< "Q9QYC0-1","RefSeq","NP_001019629.2","28982183","Reduction in ADD1 protein in NEK1 mutant mice is associated with hyperphosphorylation of ADD1, thereby preventing the interaction with MYO10 during meiotic spindle formation Publication Status: Online-Only"
< "Q9QYC0-1","RefSeq","NP_001019629.2","27068466","Adducin activity is not essential for actin ring assembly and periodicity but is necessary to control the diameter of both actin rings and axons and actin filament growth within rings."
11869a15918,15920
> "Q9R112-1","RefSeq","NP_067482.4","25130143","The present report demonstrates the presence and specific localization of SQRDL in various mammalian tissues."
> "Q9R112-1","RefSeq","NP_067482.4","21950400","Levels of mRNA encoding SQR were higher in the colonic muscularis externa and the liver than in the brain."
> "Q61781-1","RefSeq","NP_058654.1","31230446","Keratin 1 (K1) is essential for the persistent infection caused by LCMV strain MX, and its absence very effectively slows down the course of infection"
11871a15923,15925
> "Q8BYK4-1","RefSeq","NP_084293.1","22621924","RDH12 in inner segments can protect vital cell organelles against aldehyde toxicity caused by an intracellular leak of all-trans-retinal, as well as other aldehydes originating both inside and outside the cell."
> "Q8BYK4-1","RefSeq","NP_084293.1","17130236","The present findings, together with those of earlier studies showing only minor functional deficits in mice deficient for Rdh5, Rdh8, or Rdh11, suggest that the activity of any one isoform is not rate limiting in the visual response."
> "Q8BYK4-1","RefSeq","NP_084293.1","17032653","RDH12 plays a unique, nonredundant role in the photoreceptor inner segments to regulate the flow of retinoids in the eye."
11882,11883c15936,15947
< "P21836-1","RefSeq","NP_001276939.1","30076217","In melanoma, MITF overexpression induced ACHE transcription, and mutation of an E-box site in human ACHE promoter blocked this induction"
< "P21836-1","RefSeq","NP_001276939.1","29263397","Loss of acetylcholinesterase activity with mitochondrial dysfunction is associated with hypercholesterolemia. Publication Status: Online-Only"
---
> "Q8JZK6-1","RefSeq","NP_694750.3","15994318","Data show that the Rnf35 promoter is negatively modulated by the repressor element, DER, and that the 3'-half of DER (DER2) was targeted by the repressor CCAAT-displacement protein (CDP)/Cux."
> "Q8JZK6-1","RefSeq","NP_694750.3","12433986","Regulation of transcription and pre-mRNA processing of Rnf35 in eggs and in pre-implantation embryos."
> "Q8JZK6-1","RefSeq","NP_694750.3","12160726","Rnf33 and Rnf35 mRNAs are apparently transcribed from the same putative promoter and may be products of alternative splicing."
> "Q9D0U6-1","RefSeq","NP_081135.3","26910647","Can act as a transcriptional activator for PTEN, which is important for MAF1's tumor-suppressor function"
> "Q9D0U6-1","RefSeq","NP_081135.3","25934505","A whole-body knockout of Maf1 in mice confers resistance to diet-induced obesity and nonalcoholic fatty liver disease by reducing food intake and increasing metabolic inefficiency."
> "Q9D0U6-1","RefSeq","NP_081135.3","25502566","Novel role for Maf1 in suppressing both lipid biogenesis and tumor formation; Maf1 elicits these biological responses through its ability to repress genes that that synthesize lipids and regulate biosynthetic capacity. Erratum:[PLoS Genet. 2015 Mar;11(3):e1005055. PMID: 25785728] Publication Status: Online-Only"
> "Q8K2Q2-1","RefSeq","NP_084327.1","29036365","GSTO2 is transported and deposited in the postacrosomal sheath (PAS) region by the manchette, and that the late assembly of GSTO2 and its localization in the PAS suggests a role in regulating the oxidative and reductive state of covalently linked spermatid/sperm proteins, especially during the disassembly of the sperm accessory structures after fertilization"
> "Q9D103-1","RefSeq","NP_081096.3","25856311","Age-related onset of obesity corresponds with metabolic dysregulation and altered microglia morphology in mice deficient for Ifitm proteins. Publication Status: Online-Only"
> "Q9D103-1","RefSeq","NP_081096.3","16847454","The antiproliferative action of IFN-gamma requires the induction of IFITM1."
> "Q9D103-1","RefSeq","NP_081096.3","15857914","Fragilis2 regulates epithelialization of the somites and paraxial mesoderm formation."
> "P49443-1","RefSeq","NP_032936.1","28911860","VRK1 self-represses its activity to phosphorylate PXR through cyclin-dependent kinase 2 (CDK2) in high glucose conditions, resulting in the repression of the PCK1 gene. This PXR phosphorylation was also observed in fasting mouse livers. Thus, the VRK1-CDK2-PXR-PP2Calpha-SGK2 pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose."
> "P49443-1","RefSeq","NP_032936.1","25815785","Findings demonstrate a novel regulatory circuit in which STING and TBK1 reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A dephosphorylates STING and TBK1 Publication Status: Online-Only"
11910,11913c15974
< "Q8CGN4-1","RefSeq","NP_083786.2","30902969","This study provides mechanistic understanding of how BCOR regulates cell fate decisions and how loss of function contributes to the development of leukaemia. Publication Status: Online-Only"
< "Q8CGN4-1","RefSeq","NP_083786.2","30228234","Results reveal a tumor suppressor function of BCOR in myeloid malignancies and highlight the impact of Bcor insufficiency on the initiation and progression of MDS."
< "Q8CGN4-1","RefSeq","NP_083786.2","28827447","Results provide the first evidence of a tumor suppressor role for BCOR in the pathogenesis of T lymphocyte malignancies"
< "Q8CGN4-1","RefSeq","NP_083786.2","28262675","Genomic characterization of Emu-Myc mouse lymphomas identifies Bcor as a Myc cooperative tumor-suppressor gene. Publication Status: Online-Only"
---
> "Q99MX1-1","RefSeq","NP_113565.2","21449984","RT-PCR assays detected the expression of Usp26 in germ cells, but not in primary Sertoli cell lines"
11916a15978
> "O88822-1","RefSeq","NP_766357.1","28330720","Data, including data from studies in heterozygotic transgenic/knockout mice, suggest that Sc5d plays essential role in ultraviolet radiation-induced vitamin D3 synthesis in keratinocytes/skin. Homozygotic deletion of Sc5d is lethal in utero."
11922a15985,15986
> "Q9D4C1-1","RefSeq","NP_083018.1","15688036","Pas1c1(lmna-rs1) is a candidate for the Pas1 locus and the strain-specific isoforms may have differential effects on cell proliferation in lung adenoma."
> "Q9D4C1-1","RefSeq","NP_083018.1","15064703","Lmna-rs1 is part of the complex multigenic Pas1 locus. It may be a tumor suppressor. AA changes and downregulation are associated with lung adenoma susceptibility."
11924a15989,15993
> "Q8K2F0-1","RefSeq","NP_075825.3","28733670","Using pharmacological assay and RNA interference, BRD3 down-regulation resulted in enhanced myogenic differentiation. Publication Status: Online-Only"
> "Q8K2F0-1","RefSeq","NP_075825.3","27667451","Brd3 knockout significantly decreased the recruitment of acetylase CBP to IL6 gene promoter, and the acetylation level of histone3 within IL6 gene promoter was repressed."
> "Q8K2F0-1","RefSeq","NP_075825.3","24248598","Data show that infection of macrophages with Listeria monocytogenes caused binding of the BET proteins Brd2, Brd3, and, most prominently, Brd4 to the Nos2 promoter."
> "Q8K2F0-1","RefSeq","NP_075825.3","16008511","A conserved but uncharacterized gene encoding Brd3, which was down-regulated during endothelial differentiation, was identified."
> "Q8K2F0-1","RefSeq","NP_075825.3","15128596","More strongly expressed in developing testis compared with ovary"
11931a16001
> "Q8C1B7-1","RefSeq","NP_001297600.1","21824005","SEPT11 is involved in vesicle trafficking and may play a role in synaptic connectivity. Interestingly, mice that harbor a homozygous Sept11 null mutation, die in utero."
11932a16003,16004
> "Q9DBD2-1","RefSeq","NP_082196.1","27503071","CD83-mediated MHCII stabilization through antagonism of March8 as a novel functional adaptation of cortical epithelial cells for T cell selection."
> "Q9DBD2-1","RefSeq","NP_082196.1","27503069","Orchestrated regulation of MHC II surface expression in thymic epithelial cells by MARCH 8 and CD83 plays a major role in CD4(+) T cell selection."
11939c16011,16019
< "Q8BGQ1-1","RefSeq","NP_001136052.1","29409756","VPS33B and VIPAR are essential for epidermal lamellar body biogenesis and function"
---
> "Q61657-1","RefSeq","NP_032263.2","27018293","Hes3 expression is reduced at peak demyelination and is partially restored within 1 week after cuprizone withdrawal. This raises the possibility of Hes3 involvement in demyelination/remyelination."
> "P42866-1","RefSeq","NP_001291884.1","30738575","Study showed that MCRT increased colonic contraction via mu- and delta- opioid receptors."
> "P42866-1","RefSeq","NP_001291884.1","30664663","Phosphorylation-deficient Oprm1 improves analgesia and diminishes tolerance but worsens opioid side effects. Publication Status: Online-Only"
> "P42866-1","RefSeq","NP_001291884.1","17284463","Upstream open reading frames in mouse MOR mRNA act as negative regulators of translation through a ribosome leaky scanning mechanism."
> "Q9D0V7-1","RefSeq","NP_062353.3","21573489","EBAG9 overexpression can be causative in enhancing the malignant properties of tumor cells."
> "Q9D0V7-1","RefSeq","NP_062353.3","20579953","In the RCAS1 siRNA group, blood pressure was raised whereas urine albumin/creatinine ratio was increased. Our results suggest the importance of RCAS1 protein in the pathophysiologic condition of preeclampsia"
> "Q9D0V7-1","RefSeq","NP_062353.3","19620783","EBAG9 is a tunable inhibitor of CTL-mediated adaptive immune response functions."
> "Q9D0V7-1","RefSeq","NP_062353.3","19445026","EBAG9 promoted primary 4T1 mammary carcinoma growth and distant metastasis, and EBAG9 small interfering RNA exerted overt regression of tumor growth and metastasis"
> "Q9D0V7-1","RefSeq","NP_062353.3","19030177","EBAG9 may have a role in promoting progression of bladder cancer"
11948a16029,16036
> "Q9CYK2-1","RefSeq","NP_081731.1","26447138","Authors identified a placenta-specific imprinted gene Qpct. Results show that Qpct is widely expressed during early embryonic development and can be detected in the telencephalon, midbrain, and rhombencephalon at E9.5-E11.5."
> "Q9CYK2-1","RefSeq","NP_081731.1","25446989","Co-regulation of the enzyme glutaminyl cyclase and its substrate TRH was reflected by a co-induction of both proteins in reactive astrocytes in proximity of Abeta deposits"
> "Q9CYK2-1","RefSeq","NP_081731.1","24886834","This study provide a thorough comparative characterization of the glutaminyl cyclases QC and isoQC in defined brain regions of different inbred and outbred mouse strains"
> "Q9CYK2-1","RefSeq","NP_081731.1","21671571","This study presents a first comparison of two mammalian QCs (mouse and human)containing typical, conserved post-translational modifications."
> "Q9CYK2-1","RefSeq","NP_081731.1","19699792","Results describe the expression of glutaminyl cyclase throughout the mouse brain during early postnatal development."
> "Q9CYK2-1","RefSeq","NP_081731.1","19804409","Murine isoQC proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC."
> "Q9CYK2-1","RefSeq","NP_081731.1","19809370","The observations of this study indicated that brain ischemia might be a pathogenic factor of alzheimer disease through increasing BACE1, cathepsin B, and glutaminyl cyclase."
> "Q9CYK2-1","RefSeq","NP_081731.1","16201766","QC is a zinc-dependent catalyst"
11959a16048
> "P27699-1","RefSeq","NP_038526.2","30228239","CREM-/- mice were more susceptible to E. histolytica amebic colitis Publication Status: Online-Only"
11976a16066
> "E9PXX9-1","RefSeq","NP_001004184.2","19228884","The concentrative nucleoside transporter-1 (CNT1) promoter was characterized with respect to DNA response elements and their binding factors are reported."
11980a16071,16073
> "Q8R1S9-1","RefSeq","NP_081328.2","23451088","Results suggest that cysteine residues 249 and 321 form a disulfide bridge, which plays an important role in substrate transport but has no effect on trafficking of SNAT4 to the cell surface."
> "Q8R1S9-1","RefSeq","NP_081328.2","21917917","Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein"
> "Q8R1S9-1","RefSeq","NP_081328.2","11820791","Ata3 has been identified as an imprinted gene by high-throughput screening using RIKEN cDNA microarray."
11981a16075,16077
> "Q91W50-1","RefSeq","NP_659150.1","30138317","Strap associates with Csde1 and affects expression of select Csde1-bound transcripts Publication Status: Online-Only"
> "Q91YI0-1","RefSeq","NP_598529.1","30253962","We designed a codon-optimized human ASL gene packaged within adeno-associated virus serotype 8 (AAV8) as a vector for targeted delivery to the liver. To evaluate the therapeutic efficacy of this approach, we utilized a murine hypomorphic model of ASA. Neonatal administration of AAV8 via the temporal facial vein extended survival in ASA hypomorphic mice, although not to wild-type levels."
> "Q91YI0-1","RefSeq","NP_598529.1","24904080","Enterocyte-derived ASL has a protective role in necrotizing enterocolitis."
11991a16088
> "O09105-1","RefSeq","NP_031527.1","30513512","The expression of miR-544a was significantly decreased after spinal cord injury. High expression of miR-544a could alleviate the inflammation caused by spinal cord injury and promote the recovery of spinal cord via the inhibition of NEUROD4."
11993a16091,16092
> "Q8VDR9-1","RefSeq","NP_796004.2","23462102","Phosphorylation status of Dock6 at Ser(1194) determines whether it promotes axon extension or branching in sensory neurons, revealing interplay between kinase and phosphatase action on a Rho-GEF during axon growth Publication Status: Online-Only"
> "Q8VDR9-1","RefSeq","NP_796004.2","17196961","Dock6 is the GEF specific for both Rac1 and Cdc42 and may be one of physiological regulators of neurite outgrowth."
11994a16094,16097
> "O88904-1","RefSeq","NP_034562.2","30613263","The miR-200c/141 cluster regulated breast cancer stem cells heterogeneity and promoted the epithelial-mesenchymal transformation-like breast cancer stem cells generation, which resulted in increased tumor metastasis and inhibited tumor growth by directly upregulating the target gene homeodomain-interacting protein kinase 1 (HIPK1) and sequential beta-catenin activation. Publication Status: Online-Only"
> "O88904-1","RefSeq","NP_034562.2","22095214","Therefore, our data confirm that the beta-Catenin signaling plays a dual role in controlling cell proliferation/differentiation in the brain and indicate that Hipk1 is the crucial interactor able to revert the outcome of beta-Catenin signaling in cells."
> "O88904-1","RefSeq","NP_034562.2","22545114","Despite the expanded marginal zone B cell population in the HIPK1(-/-) mice, the T-independent type 2 humoral response was impaired."
> "O88904-1","RefSeq","NP_034562.2","12529400","HIPK1 and Daxx collaborate in regulating transcription."
11996a16100,16103
> "Q9JLF6-1","RefSeq","NP_064368.3","29663380","TG activity regulates differentiation, migration and fusion of osteoclasts via affecting actin dynamics and that this may involve contribution from all three TG enzymes."
> "Q9JLF6-1","RefSeq","NP_064368.3","29743665","Characterization of transglutaminase-crosslinked substrates in kidney fibrosis Publication Status: Online-Only"
> "Q9JLF6-1","RefSeq","NP_064368.3","27864691","Characterization of TGM2 and TGM1-TGM2 double knock-out mouse epidermis showed that unlike TGM2, TGM1 is indispensable for skin formation."
> "Q9JLF6-1","RefSeq","NP_064368.3","28004780","Results suggest ADAM17/EGFR-driven PLCgamma1 and PKC pathways as important promoters of TG1 expression during terminal keratinocyte differentiation. Erratum:[Sci Rep. 2017 Jan 23;7:41343. PMID: 28112251] Publication Status: Online-Only"
12021a16129,16137
> "Q9JJY9-1","RefSeq","NP_058667.1","30816423","IL22 regulates the homeostasis of the intestinal epithelium and is critical for the regeneration of the intestine during inflammation."
> "Q9JJY9-1","RefSeq","NP_058667.1","30617224","IL-22 plays a protective role by limiting infection-induced gut immunopathology but can also lead to persistent pathogen colonization."
> "Q9JJY9-1","RefSeq","NP_058667.1","30700914","Identification of a homeostatic network protecting stem cells against challenge to their genome integrity by AhR-mediated 'sensing' of genotoxic compounds from the diet; AhR signalling, in turn, ensures on-demand production of IL-22 by innate lymphocytes directly regulating components of the DNA damage response in epithelial stem cells"
> "Q9JJY9-1","RefSeq","NP_058667.1","30566883","Intestinal epithelial cells (IECs)-specific retinol dehydrogenase 7 (Rdh7) expression is required for interleukin 22 (IL-22)production by gut lymphocytes."
> "Q9JJY9-1","RefSeq","NP_058667.1","30515423","IL-22-fusion protein promotes liver regeneration in mice with pre-damaged livers following hepatectomy and alleviates ischemia-reperfusion induced liver injury Publication Status: Online-Only"
> "P11352-1","RefSeq","NP_032186.2","31059705","GPx-1 gene is a protective factor in response to reproductive dysfunction induced by cocaine in male mice, and that NFkappaB is a critical mediator of protective activity of GPx-1 gene in our experimental conditions."
> "P11352-1","RefSeq","NP_032186.2","29502249","This repletion study shows that loss of capacity to incorporate Se into Gpx1 in Gpx1 KO mice does not dramatically alter expression of other Se biomarkers, nor the short-term flux of Se from intestine to liver to kidney."
> "P11352-1","RefSeq","NP_032186.2","29908255","GPx-1 overexpression protects from memory impairment and oxidative stress."
> "P11352-1","RefSeq","NP_032186.2","28597397","GPx-1 knockout potentiated methamphetamine-induced cognitive deficits and alterations in phospho-ERK1/2 and phospho-PKCdelta expression."
12029,12033d16144
< "Q8BZ98-1","RefSeq","NP_001033708.1","28395327","In the mature epididymis, predominantly localized in principal cells of the distal segments"
< "Q8BZ98-1","RefSeq","NP_001033708.1","27251629","The data of this study demonstrated that dynamin 3 is required for the formation, functional maturation, and subsequent survival of the calyx of Held."
< "Q8BZ98-1","RefSeq","NP_001033708.1","24963135","In the developing neurons, there is a dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis. Publication Status: Online-Only"
< "Q8BZ98-1","RefSeq","NP_001033708.1","24273169","Data indicate that coxsackievirus and adenovirus receptor (CAR) internalization was lipid microdomain-, actin-, and dynamin-dependent, and subsequently followed by CAR degradation in lysosomes."
< "Q8BZ98-1","RefSeq","NP_001033708.1","19007685","Dynamin 3 participates in the growth and development of megakaryocytes."
12037a16149
> "P16043-1","RefSeq","NP_034415.1","30333823","In this animal model, the somatotrope GHRH/GH/IGF1 axis plays a vital and unsuspected role in vaccine and immunological defense against S. pneumoniae. Publication Status: Online-Only"
12042a16155
> "Q9JHX6-1","RefSeq","NP_444386.2","11852104","The loss of allantoicase activity in mouse is due to a low substrate affinity and to a reduced expression level of the enzyme."
12050,12052d16162
< "Q5XJV7-1","RefSeq","NP_082661.1","30655503","A specific subpopulation of fetal Setd5(+/-) cortical neurons showed altered gene expression of neurodevelopment-related genes. Setd5(+/-) animals manifested several autism-like behaviors, including hyperactivity, cognitive deficit, and altered social interactions. Anatomical differences were observed in Setd5(+/-) adult brains, accompanied by a deficit of deep-layer cortical neurons in the developing brain. Publication Status: Online-Only"
< "Q5XJV7-1","RefSeq","NP_082661.1","30455454","Setd5-haploinsufficient mice present abnormal brain-to-body weight ratios and neural crest defect-associated phenotypes. Setd5-mutant mice show impairments in cognitive tasks, enhanced LTP, delayed ontogenetic profile of ultrasonic vocalization, and behavioral inflexibility. Behavioral issues are accompanied by abnormal expression of postsynaptic density proteins previously associated with cognition."
< "Q5XJV7-1","RefSeq","NP_082661.1","29180574","Both SetD5 and BRD2 bind to the transcription start site and to upstream promoter regions of the Sema3a locus and BRD2 is necessary for the regulation of Sema3A expression by SetD5. Publication Status: Online-Only"
12055,12056c16165
< "Q61036-1","RefSeq","NP_001181977.1","29860311","Furthermore, pharmacological inhibition of PAKs decreases ATXN1 levels in a mouse model of SCA1. To explore the potential of using PAK inhibitors in combination therapy, we combined the pharmacological inhibition of PAK with MSK1, a previously identified modulator of ATXN1, and examined their effects on ATXN1 levels. We found that inhibition of both pathways results in an additive decrease in ATXN1 levels."
< "Q61036-1","RefSeq","NP_001181977.1","27940202","Pak3 knockout (KO) mice had defects of oligodendrocyte differentiation in developing corpus callosum and to a lesser extent in anterior commissure, which were compensated at the adult stage. In vitro experiments in oligodendrocyte precursor (OPC) cultures, derived from Pak3 KO and wild type brains, support a developmental and cell-autonomous role for PAK3 in regulating OPC differentiation into mature oligodendrocytes."
---
> "Q7TSC3-1","RefSeq","NP_808566.2","23727203","Nek5 promotes myogenic differentiation through up-regulation of caspase-3 activity."
12057a16167,16171
> "Q91X46-1","RefSeq","NP_082147.1","28542600","Data suggest that modulation of ARHGEF3 gene expression in humans with a promoter-localized SNP plays a role in human megakaryocytes and human platelet function-a finding resulting from the biological follow-up of human genetic studies. Arhgef3 KO mice partially recapitulate the human phenotype. Publication Status: Online-Only"
> "Q91X46-1","RefSeq","NP_082147.1","23192023","The crystal structure of the tandemly arranged DH-PH domains of mouse Xpln, with a single molecule in the asymmetric unit, was determined at 1.79 A resolution (Xpln)"
> "Q3U9G9-1","RefSeq","NP_598576.2","29081010","Lbr deficiency could be related to Premature Ageing reflected by enhanced accumulation of protein glycation as a biomarker for ageing."
> "Q3U9G9-1","RefSeq","NP_598576.2","28118363","The diffusional mobility of full-length LBR shows significant regional variation along the nuclear envelope, consistent with the existence of discrete LBR microdomains and the occurrence of multiple, asymmetrically-spaced anastomoses along the nuclear envelope-endoplasmic reticulum interface.  Native LBR may be 'configured' by long-range interactions between adjacent transmembrane domains and parts of the NH2 region. Publication Status: Online-Only"
> "Q3U9G9-1","RefSeq","NP_598576.2","26364738","The N-terminal portion of LBR is probably responsible for the binding to HP1b."
12064a16179,16180
> "Q921I6-1","RefSeq","NP_598577.1","22575674","SH3BP4 is a negative regulator of the Rag GTPase complex and amino acid-dependent mTORC1 signaling"
> "Q921I6-1","RefSeq","NP_598577.1","19122209","TTP Ser(245) is the principal target for the modulation of this protein via the AKT signalling cascade."
12066,12068c16182,16184
< "Q8C7Q4-1","RefSeq","NP_001277051.1","30327195","Our studies demonstrated that RBM4a-regulated alternative splicing constituted another regulatory mechanism for strengthening the influence of PRDM16 on the development of brown adipocytes."
< "Q8C7Q4-1","RefSeq","NP_001277051.1","30200638","Study identified a novel splicing network composed of RBM4a, SRSF3, and MAP4K4 in brown adipogenesis and subsequently manipulating the effect of downstream JNK signaling which contributes to insulin resistance and reduced metabolism. Publication Status: Online-Only"
< "Q8C7Q4-1","RefSeq","NP_001277051.1","29581187","RBM4 plays a role in neuronal migration via modulating the expression of Dab1 splice isoforms. This finding implies that RBM4 is necessary during brain development and that its deficiency may lead to developmental brain abnormality. Publication Status: Online-Only"
---
> "Q9R0K7-1","RefSeq","NP_033853.1","28532435","Early growth response protein 1 regulates promoter activity of alpha-plasma membrane calcium ATPase 2, a major calcium pump in the brain and auditory system Publication Status: Online-Only"
> "Q9R0K7-1","RefSeq","NP_033853.1","27702770","These findings indicate a novel role for PMCA2 in modality- and sex-dependent pain responsiveness. Female-specific molecular changes potentially account for the altered pain responses"
> "Q9R0K7-1","RefSeq","NP_033853.1","26729871","PMCA2 interacts with HER2 in specific actin-rich membrane domains."
12071,12074c16187,16192
< "P70662-1","RefSeq","NP_001106879.1","31127120","Study identifies Pax3 interaction with members of the chromatin looping complex, including the LIM-domain binding protein 1 (Ldb1) and demonstrates that Ldb1 is recruited to a subset of Pax3-bound elements characterized by increased levels of H3K4me1 deposition. Reduced Ldb1 expression impairs Pax3-dependent myogenic specification both in vitro and in vivo. Publication Status: Online-Only"
< "P70662-1","RefSeq","NP_001106879.1","30873428","Loss of Ldb1 from E8.75 using Foxg1Cre caused a disruption of midline boundary structures in the dorsal telencephalon. While this Cre line gave the expected pattern of recombination of the floxed Ldb1 locus, unexpectedly, standard Cre lines that act from embryonic day (E)10.5 (Emx1Cre) and E11.5 (NesCre) did not show efficient or complete recombination in the dorsal telencephalon by E12.5. Publication Status: Online-Only"
< "P70662-1","RefSeq","NP_001106879.1","30626972","Greek-island-bound transcription factor LHX2 and adaptor protein LDB1 regulate the assembly and maintenance of olfactory receptor compartments, Greek island hubs and olfactory receptor transcription, providing mechanistic insights into and functional support for the role of trans interactions in gene expression"
< "P70662-1","RefSeq","NP_001106879.1","16815859","Mouse Ldb1b lacks the ability to activate protein 4.2 promoter, which is stimulated by LMO2 and Ldb1. These findings suggest that splice isoforms of Ldb lacking LID are potential regulators of Ldb function.[lbd1]"
---
> "Q8BJS4-1","RefSeq","NP_919323.2","29995584","A fragment of SUN2 containing CC1, CC2, and the SUN domain model is reported."
> "Q8BJS4-1","RefSeq","NP_919323.2","19509342","These results clearly indicate that SUN1 and SUN2 function critically in skeletal muscle cells for Syne-1 localization at the nuclear envelope, which is essential for proper myonuclear positioning."
> "Q8BJS4-1","RefSeq","NP_919323.2","17452644","Sun2 is part of a membrane-spanning fibrillar complex that interconnects attached telomeres with cytoplasmic structures"
> "Q8BJS4-1","RefSeq","NP_919323.2","17132086","SUN1 and SUN2 may form a physical interaction between the nuclear envelope and the centrosome"
> "Q9ET43-1","RefSeq","NP_075028.1","20214989","1,25(OH)2D3 downregulates cadherin-17 and upregulates claudin-2 and claudin-12 in the intestine, suggesting that 1,25(OH)2D3, by regulating these epithelial cell junction proteins, can route calcium through the paracellular path"
> "Q9ET43-1","RefSeq","NP_075028.1","14698084","Claudin-12 is expressed at the variety of epithelial tissues in inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, and dark cell area."
12081,12083d16198
< "Q9Z248-1","RefSeq","NP_033767.2","25451679","The two protein isoforms of AEBP2 may have opposite functions for the PcG target genes, and may play significant roles in cell migration during development."
< "Q9Z248-1","RefSeq","NP_033767.2","19293275","A large fraction of AEBP2's target loci also map closely to the known target loci of the Polycomb Repression Complex PRC2."
< "Q5SPX1-1","RefSeq","NP_001158092.1","17971504","4930562D19Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
12090a16206,16209
> "P35292-1","RefSeq","NP_033024.1","26957544","The selectivity in syntaxin binding and apical protein redistribution further suggests that rab17 and syntaxin 2 mediate fusion of transcytotic vesicles at the apical surface."
> "P35292-1","RefSeq","NP_033024.1","23430262","Rabex-5 regulates neurite morphogenesis of hippocampal neurons by activating at least two downstream targets, Rab5, which is localized in both axons and dendrites, and Rab17, which is localized in dendrites alone"
> "P35292-1","RefSeq","NP_033024.1","22291024","Rab17 regulates dendritic morphogenesis and postsynaptic development of hippocampal neurons."
> "P35292-1","RefSeq","NP_033024.1","21291502","Data reveal new functions for recycling endosomes and Rab17 in pigmentation through a distal step in the process of melanosome release via filopodia."
12098a16218,16219
> "P31428-1","RefSeq","NP_031902.2","29863495","Contrast-induced acute kidney injury is a multistep process that involves immune surveillance by resident and infiltrating renal phagocytes, Nlrp3-dependent inflammation, and the tubular reabsorption of contrast via dipeptidase-1."
> "Q8VHX6-1","RefSeq","NP_001298003.1","26929074","HSPB7 is essential for maintaining muscle integrity, which is achieved through its interaction with FLNC"
12103a16225,16230
> "Q8CBX0-1","RefSeq","NP_766171.1","27045885","TMEM63 proteins may serve as an osmolarity sensitive ion channel for the osmoreception."
> "Q69Z98-1","RefSeq","NP_083702.1","30573363","SAD-A is activated by the incretin hormone GLP-1 in pancreatic beta-cell. SAD-A promotes the phosphorylation of Bad S155."
> "Q69Z98-1","RefSeq","NP_083702.1","29873699","Glucose and incretin stimulate insulin secretion through the phosphorylation of GDIalpha at Ser174 by SAD-A, which leads to the activation of Rho GTPases, culminating in insulin exocytosis."
> "Q69Z98-1","RefSeq","NP_083702.1","26626945","Taken together, these data suggest a model for synergistic autoinhibition and membrane activation of SAD kinases. Publication Status: Online-Only"
> "Q69Z98-1","RefSeq","NP_083702.1","17482548","Once activated, LKB1 phosphorylates and thereby activates SAD-A and SAD-B kinases, which are also required for neuronal polarization in the cerebral cortex."
> "Q69Z98-1","RefSeq","NP_083702.1","15705853","Results show that SAD-A and SAD-B, mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization."
12107a16235
> "A2A484-1","RefSeq","NP_001278087.1","28232094","A dual histone reader ZMYND8 (zinc finger MYND (Myeloid, Nervy and DEAF-1)-type containing 8), was identified to be a novel target of all trans retinoic acid."
12115a16244,16246
> "O88569-1","RefSeq","NP_872591.1","27773581","HnRNP A2/B1 loss results in alternative splicing (AS), including skipping of an exon in amyotrophic lateral sclerosis (ALS)-associated D-amino acid oxidase (DAO) that reduces D-serine metabolism."
> "O88569-1","RefSeq","NP_872591.1","27151978","A1 and A2/B1, which are required for transcript degradation"
> "O88569-1","RefSeq","NP_872591.1","26017221","Findings suggest that hnRNP A2/B1 has an important role in regulation of the innate immune system, especially at the level of monocyte/macrophage activation."
12126,12129d16256
< "Q7TPD1-1","RefSeq","NP_001074503.1","30898767","A bulla cavitation defect initiates the pathogenesis of otitis media in the established mouse model Jeff (Fbxo11(Jf/+) ). Publication Status: Online-Only"
< "Q7TPD1-1","RefSeq","NP_001074503.1","30526604","Through a loss-of-function screen authors found that a member of the E3 ubiquitin ligase complexes, FBXO11, specifically fuels tumor formation of a non-EMT-like clone by restraining the p53/p21 pathway. Interestingly, in the related EMT-like clone, FBXO11 operates through the BCL2 pathway with little or no impact on tumorigenesis. Publication Status: Online-Only"
< "Q7TPD1-1","RefSeq","NP_001074503.1","27166359","FBXO11 inactivation was associated with the development of lymphoproliferative disorders in mice."
< "Q7TPD1-1","RefSeq","NP_001074503.1","26471094","FBXO11 regulates the TGF-beta pathway in the embryonic lung via cross-talk with p53."
12144a16272
> "Q07563-1","RefSeq","NP_031758.2","28693719","Here, the authors show that COL17 plays a central role in regulating interfollicular epidermis (IFE) proliferation. Loss of COL17 leads to transient IFE hypertrophy in neonatal mice owing to aberrant Wnt signaling. Publication Status: Online-Only"
12151a16280,16281
> "Q61458-1","RefSeq","NP_075732.1","20231280","Investigated the function of the Cdk7.cyclin H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells"
> "Q61458-1","RefSeq","NP_075732.1","11731416","Inactivation of the retinoblastoma tumor suppressor induces apoptosis protease-activating factor-1 dependent and independent apoptotic pathways during embryogenesis."
12157a16288,16289
> "Q6YNI2-1","RefSeq","NP_951013.1","17934457","Gpr6 is the first striatopallidal neuron-specific genetic regulator of instrumental conditioning in a mammal."
> "Q6YNI2-1","RefSeq","NP_951013.1","14592418","Identification, characterization and cloning; identified sphingosine-1-phosphate as a high-affinity ligand"
12161a16294,16296
> "Q8BVG8-1","RefSeq","NP_958743.1","19807691","Results indicated that NAT8L, but not NAT14, catalysed the synthesis of NAA from L-aspartate and acetyl-CoA. Publication Status: Online-Only"
> "Q6P9S0-1","RefSeq","NP_941027.1","23060091","ABBA promotes cell spreading."
> "Q6P9S0-1","RefSeq","NP_941027.1","18413296","This study identifies ABBA as a novel regulator of actin and plasma membrane dynamics in radial glial cells."
12167a16303,16305
> "Q62523-1","RefSeq","NP_035907.1","29967145","These observations suggest that Zyxin promotes colon cancer tumorigenesis in a mitotic-phosphorylation-dependent manner and through CDK8-mediated YAP activation."
> "Q62523-1","RefSeq","NP_035907.1","28256511","Study findings identify zyxin as a physiological regulator of endothelial exocytosis through reorganizing local actin network in the final stage of exocytosis. Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defective endothelial secretion of VWF. Publication Status: Online-Only"
> "Q62523-1","RefSeq","NP_035907.1","12482962","Mice that lack zyxin function are viable and fertile and display no obvious histological abnormalities in any of the organs examined.Specifically, we evaluated blood platelet function, nervous system development, and skin architecture"
12175a16314,16316
> "Q9Z0X1-1","RefSeq","NP_036149.1","29780003","We provide evidence that the disease-associated apoptosis-inducing factor (AIF) deletion arginine 201 (R200 in rodents) causes pathology in knockin mice. Aifm1 (R200 del) knockin mice manifest peripheral neuropathy."
> "Q9Z0X1-1","RefSeq","NP_036149.1","29323266","Data reveal that the mitochondrial signals regulated by AIF are critical to hematopoietic decision-making. Emerging as a link between mitochondrial metabolism and hematopoietic cell fate, AIF-mediated OXPHOS regulation represents a target for the development of new immunomodulatory therapeutics."
> "Q9Z0X1-1","RefSeq","NP_036149.1","28666871","The first structure of a pathogenic AIF variant in complex with NAD+ is reported. The G307E mutation leads to wrong positioning of NAD+ adenylate moiety."
12177a16319,16326
> "Q9D8N6-1","RefSeq","NP_083653.1","28920576","Thus, Lin37 is an essential component of DREAM complex that cooperates with Rb to induce quiescence. Publication Status: Online-Only"
> "Q3UJF0-1","RefSeq","NP_001028462.2","30841431","GPR55 might be a therapeutic target for T2DM."
> "Q3UJF0-1","RefSeq","NP_001028462.2","30196316","The study reveals changes in gene expression of members of the endocannabinoid system in situ attesting particularly GPR55 and MGL a distinct cellular role in the regulation of the immune response to intestinal and systemic inflammation."
> "Q3UJF0-1","RefSeq","NP_001028462.2","30148676","Findings identify GPR55 as a positive regulator of insulin action and adipogenesis and as a potential therapeutic target for countering obesity-induced metabolic dysfunction and insulin resistance"
> "Q3UJF0-1","RefSeq","NP_001028462.2","30061636","Our results demonstrate the important role played by GPR55 ...in pancreatic ductal adenocarcinoma progression"
> "Q3UJF0-1","RefSeq","NP_001028462.2","29888782","Our findings support the hypothesis that neural stem cells (NSC) express functional GPR55 and that targeting GPR55 with selective agonists increases NSC proliferation and early neurogenesis both in vitro and in vivo. A better understanding of the role GPR55 plays during neurogenesis may provide new prospects for therapeutic treatments utilizing this receptor as a target."
> "Q3UJF0-1","RefSeq","NP_001028462.2","19464294","GPR55 might be involved in neuroinflammation and its expression is controlled by the state of microglial activation."
> "Q3UJF0-1","RefSeq","NP_001028462.2","18502582","In a model of neuropathic hypersensitivity, there is no mechanical hyperalgesia present in male or female GPR55-deficient mice at any time point up to 28 days post-ligation."
12188a16338,16345
> "Q3ULW8-1","RefSeq","NP_663594.2","30213852","These data indicate that Parp3 and Parp1 promote rearrangements with distinct phenotypes."
> "Q3ULW8-1","RefSeq","NP_663594.2","26000965","We show that Poly(ADP)ribose polymerase 3 (Parp3), an enzyme recently implicated in DNA repair, contributes to antibody diversification by negatively regulating class switch recombination without affecting somatic hypermutation. Publication Status: Online-Only"
> "Q3ULW8-1","RefSeq","NP_663594.2","21211721","PARP-3 has a role in chromosomal DNA double-strand break repair."
> "Q3ULW8-1","RefSeq","NP_663594.2","12448766","We cloned and sequenced the cDNAs of the mouse PARP-3 (Adprt3) gene encoding poly(ADP-ribose) polymerase 3 and of the closely linked U3-55k gene coding for the U3 small nucleolar ribonucleoprotein complex-associated 55-kilodalton protein."
> "O54790-1","RefSeq","NP_034886.1","29138682","In condition of hypoxia, MAFG induction correlated with reduced levels of miR-128. This lead to increased mRNA levels of HMOX-1 and x-CT for blunting stress. Overall, these findings identify MAFG as novel direct target of miR-128."
> "O54790-1","RefSeq","NP_034886.1","26677805","The CNC-sMaf binding element is strictly required for the Nrf2-sMaf heterodimer function in cytoprotection."
> "O54790-1","RefSeq","NP_034886.1","25896808","These data identify Mafg and Mafk as new cataract-associated candidates and define their function in regulating largely non-crystallin genes linked to human cataract."
> "O54790-1","RefSeq","NP_034886.1","25651182","The MafG as an FXR target gene and show that hepatic MAFG expression represses genes of the bile acid synthetic pathway and modifies the biliary bile acid composition. Erratum:[Cell Metab. 2016 Mar 8;23(3):563]"
12204a16362,16365
> "O89109-1","RefSeq","NP_032459.3","30857243","Inducible KCa3.1 overexpression alters intestinal functions by increasing the chyme content and reducing spontaneous contractions and epithelial apoptosis. Induction of epithelial KCa3.1 can play a mechanistic role in the process of adaptation of the intestine. Publication Status: Online-Only"
> "O89109-1","RefSeq","NP_032459.3","30808854","Data show a) a profound upregulation of KCNN4 in stimulated kidney fibroblast and b) identifies miR-503 as a regulator of KCNN4 expression"
> "O89109-1","RefSeq","NP_032459.3","30207167","Caveolae provide a key microdomain in renal collecting duct cells for coupling of TRPV4 with SK3, IK1, and BK that directly contributes to TRPV4-mediated Ca(2+) signaling in these domains."
> "O89109-1","RefSeq","NP_032459.3","12882916","SK1, -2, -3, and IK1 (SK4) are expressed in islet cells and insulin-secreting cells and are able to influence glucose-induced calcium responses, thereby regulating insulin secretion."
12205a16367,16368
> "Q9ET38-1","RefSeq","NP_694745.1","25678664","This study presents the structure of mammalian claudin-19 in complex with C-CPE at 3.7 A resolution."
> "Q9ET38-1","RefSeq","NP_694745.1","15589828","Sp1 site is crucial for Cldn19 gene expression in kidney cells."
12207a16371,16377
> "Q8VEH2-1","RefSeq","NP_082688.1","30098009","CDKN1A interacting zinc finger protein 1 (Ciz1) knockout mice (Ciz1(DeltaE5/DeltaE5) ) lose residues encoded by exon 5 but may gain function from novel amino acid sequences."
> "Q8VEH2-1","RefSeq","NP_082688.1","29154038","It plays a critical role in DNA replication and cell-cycle progression at the G1/S checkpoint."
> "Q8VEH2-1","RefSeq","NP_082688.1","28546514","CIZ1 is recruited to Xi in response to expression of X inactive-specific transcript (Xist) RNA during the earliest stages of X inactivation in embryonic stem cells and is dependent on the C-terminal nuclear matrix anchor domain of CIZ1 and the E repeats of Xist CIZ1-null mice, although viable, display fully penetrant female-specific lymphoproliferative disorder."
> "Q8VEH2-1","RefSeq","NP_082688.1","19124469","Glucocorticoid-responsive elements proximal to the Lcn2 promoter apparently functions to regulate both the Lcn2 gene and the distal Ciz1 gene."
> "Q8VEH2-1","RefSeq","NP_082688.1","17508423","Conditional exclusion of exon 4 influences the spatial distribution of the Ciz1 protein within the nucleus, showing that CIZ1 alternative splicing could influence organized patterns of DNA replication"
> "Q8VEH2-1","RefSeq","NP_082688.1","17182902","Ciz1 is composed of two functionally distinct domains: an N-terminal replication domain and a C-terminal nuclear matrix anchor"
> "Q8VEH2-1","RefSeq","NP_082688.1","15585571","Ciz1 promotes DNA replication."
12219,12223c16389
< "Q8CGN5-1","RefSeq","NP_001106942.1","30042231","Plin1 is required to restrain fat loss and pro-inflammatory responses in adipose tissue by reducing futile lipolysis to maintain metabolic homeostasis."
< "Q8CGN5-1","RefSeq","NP_001106942.1","29407594","Overexpressed PLIN1 in macrophages had a protected role against atheroma progression in ApoeKO in the absence of changes in gonadal fat mass or plasma lipid levels, presumably due to modification of the stability and/or inflammatory profile of macrophages."
< "Q8CGN5-1","RefSeq","NP_001106942.1","29191637","This mouse model might mimic and explain the pathogenesis of hepatosteatosis occurring in two typical disorders of adipose tissue dysfunction, obesity and lipodystrophy, particularly in lipodystrophic patients with Plin1 mutation."
< "Q8CGN5-1","RefSeq","NP_001106942.1","12407111","The central 25% of the perilipin A sequence contains all of the amino acids necessary to target and anchor the protein to lipid droplets"
< "Q8CGN5-1","RefSeq","NP_001106942.1","11751901","Perilipin expression and phosphorylation state are critical regulators of lipid storage and hydrolysis in ACS1/FATP1 cells."
---
> "P0DOV1-1","RefSeq","NP_001288674.1","23145002","The role of Mnda in response to apoptosis and genotoxic stress is discussed."
12227a16394,16399
> "Q9D379-1","RefSeq","NP_034275.1","29717038","High epoxide hydrolase expression is associated with colonic inflammation."
> "Q9D379-1","RefSeq","NP_034275.1","29030652","Microsomal epoxide hydrolase forms complex with CYP2J5 in the endoplasmic reticulum."
> "Q9D379-1","RefSeq","NP_034275.1","28975360","MEH appears to play a leading role in the hydrolysis of 8,9-epoxyeicosatrienoic acid and also contributes to the hydrolysis of other fatty acid epoxides."
> "Q9D379-1","RefSeq","NP_034275.1","28736260","These findings show the critical role of soluble epoxide hydrolase S-nitrosation in cardiac ischemia-reperfusion injury."
> "Q9D219-1","RefSeq","NP_084209.3","28174279","Transcriptional cofactors Bcl9, Bcl9l and Pygo1/2 act independently of beta-catenin to ensure proper enamel formation. Publication Status: Online-Only"
> "Q9D219-1","RefSeq","NP_084209.3","28103279","ARX positively regulates Wnt/ beta-catenin signaling and the C-terminal domain of ARX interacts with the armadillo repeats in beta-catenin to promote Wnt/beta-catenin signaling. In addition, we found BCL9 and P300 also interact with ARX to modulate Wnt/beta-catenin signaling. Publication Status: Online-Only"
12229a16402
> "Q8CDP0-1","RefSeq","NP_848745.2","25103237","CCP2 and CCP3 are deglutamylases and are highly regulated proteins confined to ciliated tissues."
12232a16406,16410
> "O70451-1","RefSeq","NP_035521.1","30297875","MCT2 dictates the mode of action of N-oxalylglycine (NOG) by determining its intracellular concentration"
> "O70451-1","RefSeq","NP_035521.1","28687765","MCT1 and MCT2 not only play an important role in the transport of ketone bodies, but also in the modulation of brain energy metabolism under normal and ketogenic conditions. Publication Status: Online-Only"
> "O70451-1","RefSeq","NP_035521.1","28281525","Adipocytes promote malignant growth of mammary gland tumors with MCT2 expression via beta-hydroxybutyrate. Publication Status: Online-Only"
> "O70451-1","RefSeq","NP_035521.1","26751713","This study demonstrated that MCT2 was up regulation in ipsilateral site of brain afeter cerebral ischemia."
> "O70451-1","RefSeq","NP_035521.1","11973431","Data provide convincing evidence that MCT2 represents a major neuronal monocarboxylate transporter in the adult mouse brain"
12234,12235d16411
< "Q60597-1","RefSeq","NP_001239216.1","28242228","Taken together, our results indicate that the redox sensing and ROS forming properties of Pdh and Ogdh are linked to S-glutathionylation"
< "Q60597-1","RefSeq","NP_001239216.1","27582470","We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase and induces histone modifications in an ACL-dependent manner"
12244a16421,16423
> "Q9R0Q3-1","RefSeq","NP_062744.1","28797121","Histological and molecular analysis of livers from heterozygous mice carrying the 99J mutation, Tmed299J/+, revealed a requirement for TMED2 in liver health. The study shows that Tmed299J/+ mice had decreased levels of TMED2 and TMED10, dilated endoplasmic reticulum membrane, and increased phosphorylation of eIF2alpha, indicating endoplasmic reticulum - stress. Publication Status: Online-Only"
> "Q9R0Q3-1","RefSeq","NP_062744.1","20712584","Tmed2, which has never been reported yet in cell proliferation, was verified to be able to enhance MC3T3-E1 cell proliferation when over-expressed"
> "Q9R0Q3-1","RefSeq","NP_062744.1","20178780","Study finds that Tmed2/p24beta(1) is normally expressed in tissues showing morphological defects in 99J mutant embryos and that these affected tissues lack the TMED2/p24beta(1) oligomerization partners, TMED7/p24gamma(3) and TMED10/p24delta(1)."
12247,12252c16426,16429
< "Q8R1G6-1","RefSeq","NP_001240665.1","29852170","Reducing NF-kappaB activation attenuates PDLIM2 deficiency-exacerbated inflammation and dyslipidemia in Palmitate -treated primary hepatocytes."
< "Q8R1G6-1","RefSeq","NP_001240665.1","28315683","Klotho can modulate inflammation via PDLIM2/NF-kappaB p65 pathway in cyclosporine A-induced nephropathy."
< "Q8R1G6-1","RefSeq","NP_001240665.1","22155789","Deficiency in PDLIM2 resulted in the accumulation of STAT3 in the nucleus, enhanced the extent of TH17 cell differentiation, and exacerbated granuloma formation. Publication Status: Online-Only"
< "Q8R1G6-1","RefSeq","NP_001240665.1","17468759","PDLIM2 deficiency resulted in larger amounts of nuclear p65, defective p65 ubiquitination and augmented production of proinflammatory cytokines in response to innate stimuli"
< "Q8R1G6-1","RefSeq","NP_001240665.1","15963787","SLIM is a novel ubiquitin E3 ligase whose targets include STAT proteins."
< "Q8R1G6-1","RefSeq","NP_001240665.1","15659642","Knockdown of Mystique 2 with small interfering RNA abrogated both adhesion and migration in MCF10A and MCF-7 cells"
---
> "P61249-1","RefSeq","NP_076387.2","25739440","Pde6h deficiency mice suggests no defects in cone/rod-driven retinal signaling and therefore preserved visual functions."
> "P61249-1","RefSeq","NP_076387.2","19878658","The interdependency of phosphorylation of T22 and T35 suggests that light-induced, post-translational modification of PDE6gamma is essential for the regulation of G-protein signaling."
> "P61249-1","RefSeq","NP_076387.2","16641226","Our results show that the PDE6gamma binding sites of PDE6 alpha and beta are accessible to excess (presumably cytoplasmic) PDE6gamma in the light, once endogenous PDE6gamma has been displaced from its binding site by Talpha-GTP."
> "J3QNB7-1","RefSeq","NP_001182655.1","26407640","Data show that Fam181a presents partially overlapping mRNA expression with Fam181b during embryonic development and encodes for protein containing highly-conserved motifs with mainly nuclear localization."
12264a16442,16443
> "Q80VP2-1","RefSeq","NP_849245.2","29899041","The absence of Spata7 results in the mislocalization of DCC proteins without affecting the proximal connecting cilium (PCC) protein complexes."
> "Q80VP2-1","RefSeq","NP_849245.2","19268277","Spata7 is expressed in the mature mouse retina. Erratum:[Am J Hum Genet. 2010 Feb;86(2):293. Abboud, Emad B [added]; Al-Rajhi, Ali A [added]]"
12268,12271d16446
< "Q8K4K6-1","RefSeq","NP_001107811.1","26549575","Pank1 genetic deficiency can be corrected using phosphopantothenate diet replacement therapy."
< "Q8K4K6-1","RefSeq","NP_001107811.1","24781151","The results indicate that Pank1 deficiency drives a whole-body metabolic adaptation that improves aspects of the diabetic phenotype and uncouples hyperglycaemia and hyperinsulinaemia from obesity in leptin-deficient mice."
< "Q8K4K6-1","RefSeq","NP_001107811.1","23343762","P53 plays an important role in regulating energy homeostasis through transcriptional control of PANK1."
< "Q8K4K6-1","RefSeq","NP_001107811.1","20559429","Data illustrate the importance of PanK1 and elevated liver CoA levels during fasting to support the metabolic transition from glucose utilization and fatty acid synthesis to gluconeogenesis and fatty acid oxidation Publication Status: Online-Only"
12278a16454,16458
> "Q8BH61-1","RefSeq","NP_083060.2","28596376","Suggest that resident macrophages maintain plasma FXIII-A and exclude the platelet lineage as a major contributor."
> "Q8BH61-1","RefSeq","NP_083060.2","28387755","Factor XIII-A and TG2 regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow."
> "Q8BH61-1","RefSeq","NP_083060.2","15131115","Platelet FXIII and calpain have roles in regulating integrin alpha(IIb)beta3 adhesive function"
> "Q8BH61-1","RefSeq","NP_083060.2","12933578","Maternal FXIII plays a critical role in uterine hemostasis and maintenance of the placenta during gestation."
> "Q8BH61-1","RefSeq","NP_083060.2","12529747","Impaired clot stabilization in FXIII-A mutant mice"
12287a16468,16471
> "Q9D0U9-1","RefSeq","NP_081131.1","29491146","Arv1-/- animals fed a high-fat diet were resistant to diet-induced obesity, had lower blood cholesterol and triglyceride levels, and retained glucose tolerance and insulin sensitivity."
> "Q9D0U9-1","RefSeq","NP_081131.1","27270415","In contrast to wild type human ARV1, neither variant expressed detectable levels of protein in mammalian cells. Mice with a neuronal deletion of Arv1 recapitulated the human phenotype, exhibiting seizures and a severe survival defect in adulthood. Our data support ARV1 deficiency as a cause of autosomal recessive epileptic encephalopathy"
> "Q9D0U9-1","RefSeq","NP_081131.1","24273168","These results implicate ARV1 as a protective factor in lipotoxic diseases due to modulation of fatty acid metabolism."
> "Q9D0U9-1","RefSeq","NP_081131.1","20663892","Arv1p has a role in sterol movement from the ER and in the ensuing regulation of hepatic cholesterol and bile acid metabolism"
12288a16473,16475
> "Q02152-1","RefSeq","NP_032337.2","29920354","Our results make clear that peripheral HTR2B expression is required specifically for itch behaviors evoked by SSRIs, 5-HT, and alpha-Me-5HT."
> "Q02152-1","RefSeq","NP_032337.2","29453444","These observations indicate that the 5-HT2B receptor acts as a direct positive modulator of serotonin Pet1-positive neurons in an opposite way as the known 5-HT1A negative autoreceptor."
> "Q02152-1","RefSeq","NP_032337.2","28258217","Heterodimerization with 5-HT2C receptors does not alter 5-HT2C Galphaq-dependent inositol phosphate signaling, 5-HT2A or 5-HT2B receptor-mediated signaling was totally blunted. This feature can be explained by a dominance of 5-HT2C on 5-HT2A and 5-HT2B receptor binding; in 5-HT2C-containing heterodimers, ligands bind and activate the 5-HT2C protomer exclusively."
12295a16483
> "P48301-1","RefSeq","NP_035695.1","25588835","Cells with reduced Tead activity became losers, whereas cells with increased Tead activity became super-competitors. Tead directly regulated Myc RNA expression, and cells with increased Myc expression also became super-competitors."
12302a16491,16496
> "Q9ERS2-1","RefSeq","NP_075801.1","29078279","At the basal state, a moderate down-regulation of NDUFA13 created a leak within complex I, resulting in a mild increase in cytoplasm localized Hydrogen Peroxide, but not superoxide. The resultant reactive oxygen species served as a second messenger and was responsible for the STAT3 dimerization and, hence, the activation of antiapoptotic signaling."
> "Q9ERS2-1","RefSeq","NP_075801.1","28903530","INGR-GRIM-19 has an efficient antitumor activity in vitro and in vivo, and might be a promising agent for the treatment of colorectal cancer."
> "Q9ERS2-1","RefSeq","NP_075801.1","27346638","The protein and mRNA levels of GRIM-19 were markedly decreased on Day 4 of pregnancy, but there was no change in GRIM-19 levels in a group of pseudopregnant mice. Overexpression of GRIM-19 decreased the adhesion rate of RL95-2-BeWo co-cultured spheroids and increased apoptosis."
> "Q9ERS2-1","RefSeq","NP_075801.1","27789183","NDUFA13 deficiency may be associated with asthenozoospermia through the disturbance of spermatozoa mitochondrial membrane potential and by increasing apoptosis and intracellular reactive oxygen species"
> "Q9ERS2-1","RefSeq","NP_075801.1","27391226","Transplantation from GRIM19-overexpressing cells downregulated the expression of nuclear factor of activated T cells (NFATc1) but promoted the expression of regulator of calcineurin (RCAN)3 while downregulating NFAT-dependent cytokine gene expression. Publication Status: Online-Only"
> "Q9ERS2-1","RefSeq","NP_075801.1","12163600","Results collectively indicate that viral interferon regulatory factor 1 modulates interferon/retinoic acid-cell death signals via interactions with GRIM19"
12320a16515
> "Q8R3J4-1","RefSeq","NP_079823.2","17662942","MTERF3 is the first example of a mitochondrial protein that acts as a specific repressor of mammalian mtDNA transcription initiation in vivo."
12323a16519,16529
> "Q9ESN6-1","RefSeq","NP_109631.2","21478148","A role for TRIM2 in mediating the p42/p44 MAPK-dependent ubiquitination of Bim in rapid ischemic tolerance."
> "Q9ESN6-1","RefSeq","NP_109631.2","20796172","Trim2 has an important function in the regulation of axon outgrowth during development."
> "Q9ESN6-1","RefSeq","NP_109631.2","18687884","TRIM2 is an ubiquitin ligase and point to a mechanism regulating neurofilament light subunit metabolism through an ubiquitination pathway that, if deregulated, triggers neurodegeneration"
> "Q80UL9-1","RefSeq","NP_001005421.3","30055289","Findings suggest that specific JAM family members play an important role in the transendothelial migration (TEM) of in vitro-generated mouse and human dendritic cells (DCs) from the inoculation site to regional lymph nodes (LNs) in DC-based cancer immunotherapy."
> "Q80UL9-1","RefSeq","NP_001005421.3","21220118","Crystal structure of the JAML-HL4E10 Fab complex"
> "Q80UL9-1","RefSeq","NP_001005421.3","20813955","Crystal structure of junctional adhesion molecule-like protein (JAML) and coxsackie and adenovirus receptor; data show how CAR-mediated clustering of JAML recruits phosphoinositide 3-kinase to a JAML intracellular sequence motif"
> "Q80UL9-1","RefSeq","NP_001005421.3","20813954","Identified an epithelial gammadelta T cell costimulatory molecule, junctional adhesion molecule-like protein - JAML; binding of JAML to CAR provides costimulation leading to cell proliferation and cytokine and growth factor production"
> "Q0VBD2-1","RefSeq","NP_081566.2","21693137","Genetic evidence for an essential and non-redundant physiological role of MCM10 during murine peri-implantation development."
> "Q2M3X8-1","RefSeq","NP_001289565.1","28803787","That Phactr1 takes part in neuronal functions regulated in a spatiotemporal manner"
> "Q2M3X8-1","RefSeq","NP_001289565.1","28720499","It has been demonstrated that PHACTR1 gene expression increases with the progression of vascular calcification and that regulation of PHACTR1 in smooth muscle cells modulates the severity of vascular calcification."
> "Q2M3X8-1","RefSeq","NP_001289565.1","22766235","This study demonistrated that Phactr1 appeared to be expressed in post-mitotic neurons in developmental brain."
12330a16537,16538
> "Q3UTJ2-1","RefSeq","NP_001297636.1","27530683","The nArgBP2 binds to the two most prominent postsynaptic proteins that are associated with various mood disorders, we propose that nArgBP2could function as a hub able to link together etiological factors of different disorders."
> "Q3UTJ2-1","RefSeq","NP_001297636.1","27033308","The present study provides strong evidence that miR-21-3p controls sepsis-associated cardiac dysfunction via regulating SORBS2. Inhibition of miR-21-3p might be a protective strategy to treat sepsis-induced cardiac dysfunction."
12335a16544,16550
> "Q99P58-1","RefSeq","NP_085031.3","29479064","MiR-34c-5p could increase its intracellular level by inhibiting exosome-mediated transfer via a positive feedback loop through RAB27B, a molecule that promotes exosome shedding."
> "Q99P58-1","RefSeq","NP_085031.3","28978688","This study shows that Rab27a and Rab27b double-knockout mice that are deficient in exosome secretion have a chronic, low-grade inflammatory phenotype characterized by elevated inflammatory cytokines and myeloproliferation"
> "Q99P58-1","RefSeq","NP_085031.3","28910634","While RAB11a recruits its effector RAB11FIP3 and cytoskeletal motor Dynein, RAB27b mobilizes the effector MyRIP and motor Myosin VIIa to mediate bacterial expulsion."
> "Q99P58-1","RefSeq","NP_085031.3","12122117","Rab27b is functionally redundant with Rab27a and the pathogenesis of Griscelli syndrome is determined by the relative expression of Rab27a and Rab27b in specialized cell types. Erratum:[J Clin Invest 2002 Oct;110(8):1213]"
> "Q99P58-1","RefSeq","NP_085031.3","12060386","Rab27b may regulate the outward movement of melanosomes and the formation or maintenance of dendritic extensions in melanocytes."
> "Q99P58-1","RefSeq","NP_085031.3","11956164","Rab27b is involved in pituitary hormone secretion"
> "Q99P58-1","RefSeq","NP_085031.3","11178108","Chromosomal mapping and gene structure of the RAB27B gene."
12344a16560,16563
> "Q9WU38-1","RefSeq","NP_035455.1","28877879","Apical fluid shear stress specifically downregulates beta-ENaC and gamma-ENaC subunits at the transcriptional level through an unidentified heat-insensitive paracrine basolateral factor in collecting duct principal cells."
> "Q9WU38-1","RefSeq","NP_035455.1","29187368","N-linked glycans on each subunit are required for proper folding, maturation, surface expression, and function of the epithelial sodium channel."
> "Q9WU38-1","RefSeq","NP_035455.1","29021227","Casein kinase 2 phosphorylation is an important regulator of ENaC activity and sodium handling by the aldosterone sensitive distal nephron."
> "Q9WU38-1","RefSeq","NP_035455.1","29107074","Loss of betaENaC function resulted in meibomian gland disease and severe ocular surface damage that phenocopied aspects of human pseudohypoaldosteronism-1 MG disease and was sex dependent."
12360a16580,16581
> "Q8VCF1-1","RefSeq","NP_083778.2","28330694","CANT1 long non-coding RNA triggers efficient therapeutic efficacy by correcting aberrant long non-coding cascade in malignant uveal melanoma."
> "Q8VCF1-1","RefSeq","NP_083778.2","22451650","Restoring CANT1 levels in neuroblastoma clones recovered the phenotype, thus confirming a key role of CANT1, and of the regulation of its gene by DREAM, in the control of protein synthesis and degradation"
12379c16600,16601
< "P25085-1","RefSeq","NP_001034790.1","29891552","These data reveal that IL-1Ra and IL-36Ra have opposing effects on the outcome of Pseudomonas aeruginosa keratitis"
---
> "Q61411-1","RefSeq","NP_032310.2","30655611","Study identifies WD40-repeat protein 76 (WDR76) as one of the HRAS binding proteins using proteomic analyses of hepatocellular carcinomas tissue form human patients and mouse diethylnitrosamine-induced liver carcinogenesis model and demonstrates that WDR76 functions as a tumor suppressor via RAS degradation. Publication Status: Online-Only"
> "Q61411-1","RefSeq","NP_032310.2","29720552","Mice lacking R-Ras1 and/or R-Ras2 show a diminished oligodendrocytes population with a higher proportion of immature oligodendrocytes, explaining the observed hypomyelination"
12388d16609
< "P27699-1","RefSeq","NP_001104329.1","30228239","CREM-/- mice were more susceptible to E. histolytica amebic colitis Publication Status: Online-Only"
12391a16613,16614
> "P0C605-1","RefSeq","NP_035290.1","30327468","Prkg1 cascade role in platelet activation and thrombosis. Erratum:[Nat Commun. 2018 Nov 20;9(1):4969. PMID: 30459325] Publication Status: Online-Only"
> "P0C605-1","RefSeq","NP_035290.1","30152261","These data thus demonstrate the existence of two differently distributed cGKI isoforms in the dorsal root ganglion, and may provide insight into the cellular and molecular mechanisms of pain."
12398,12399c16621,16629
< "Q6NZN1-1","RefSeq","NP_001074683.1","25994039","These results indicated an elevated basal metabolic rate and lipid metabolic alteration of male Pprc1(+/-) mice on high-fat diet, suggesting the significant role of Pprc1 in controlling mitochondrial gene expression and energy metabolic processes"
< "Q6NZN1-1","RefSeq","NP_001074683.1","22411706","Homozygous deficient PPRC1 mice failed to form egg cylinders and died after implantation but before embryonic day 6.5, whereas mice heterozygous for PPRC1 were viable, fertile and indistinguishable from their wild-type littermates."
---
> "P57724-1","RefSeq","NP_067542.3","26915821","The p53-PCBP4-ZFP871 axis represents a novel feedback loop in the p53 pathway."
> "Q14BI1-1","RefSeq","NP_001103710.1","28547530","Both CaMKII autophosphorylation and CaMKIV phosphorylation significantly decreased in hippocampal CA1 regions of NCKX2+/- relative to control mice."
> "Q14BI1-1","RefSeq","NP_001103710.1","27580676","It has been concluded that NCKX2 is required for the maintenance of efficient Ca2+ extrusion from mouse cones. Publication Status: Online-Only"
> "Q14BI1-1","RefSeq","NP_001103710.1","26410028","Studies describe for the first time the exact location of K(+)-dependent Na(+)/Ca(2)-exchanger (solute carrier family 24, member 2) in the hippocampus of adult mice."
> "Q14BI1-1","RefSeq","NP_001103710.1","18166528","Non-synonymous single nucleotide polymorphism in SLC24A5 alters a residue that is important for NCKX5 and NCKX2 activity"
> "Q14BI1-1","RefSeq","NP_001103710.1","18305240","NCKX2 is involved in brain ischemia, and it may represent a new potential target to be investigated in the study of the molecular mechanisms involved in cerebral ischemia."
> "Q14BI1-1","RefSeq","NP_001103710.1","9461611","Mouse ortholog of rat Slc24a2 solute carrier family 24, encoding a potassium-dependent sodium-calcium exchanger (partial cds)"
> "Q3TVI8-1","RefSeq","NP_666243.1","30659184","HPIP promotes the transcription of Wnt targets by interacting with lymphoid enhancer binding factor 1 (LEF1). HPIP potentiates the transcriptional activity of LEF1 and acetylates histone H3 lysine 56 in the promoters of Wnt targets, suggesting that HPIP is an attractive target in OA regulatory network. Publication Status: Online-Only"
> "Q3TVI8-1","RefSeq","NP_666243.1","22383461","Mouse spermatogonial stem cells expressed Tex11, Hpip, and Esr2 but not Esr1, and in cultured cells, TEX11 competed with Esr2 for binding to HPIP."
12408,12411c16638,16639
< "Q01147-1","RefSeq","NP_034082.1","31127098","Selective disruption of CREB function in medial prefrontal cortex (mPFC) engram cells after mild conditioning impairs remote memory expression. Memory consolidation by mPFC engram cells requires CREB-mediated transcription, with the functionality of this network hub being gated by memory strength. Publication Status: Online-Only"
< "Q01147-1","RefSeq","NP_034082.1","30822571","In model of vascular injury lncRNA-SRA promoted vascular smooth muscle cell proliferation by activating the MEK-ERK-CREB pathway."
< "Q01147-1","RefSeq","NP_034082.1","30709903","Iron down-regulates leptin by decreasing CREB glycosylation, resulting in increased CREB phosphorylation and leptin promoter occupancy by pCREB."
< "Q01147-1","RefSeq","NP_034082.1","31023055","Our data suggest that over expression of CREB may contribute to progression of glioma and knockdown of CREB expression may serve as a novel target for therapy"
---
> "Q61730-1","RefSeq","NP_598864.1","25449578","We conclude that neuron-specific AcPb plays a critical role in host defenses and sleep homeostasis."
> "Q61730-1","RefSeq","NP_598864.1","25908590","These results thus reveal the decoding mechanism of splice-insert signaling codes for synaptic differentiation induced by trans-synaptic adhesion between PTPdelta and IL1RAPL1/IL-1RAcP. Publication Status: Online-Only"
12418,12422c16646,16648
< "Q4U4S6-1","RefSeq","NP_001019789.1","25772365","XIRP2 is required for maintenance of stereocilia integrity."
< "Q4U4S6-1","RefSeq","NP_001019789.1","25653358","XIRP2 is required for long-term maintenance of hair cell stereocilia, and its dysfunction causes hearing loss."
< "Q4U4S6-1","RefSeq","NP_001019789.1","23261932","Data show that mXinbeta (CMYA3/XIRP2) but not mXinalpha ((CMYA1/XIRP1) was uniquely up-regulated during the redistribution of intercellular junction from the lateral membrane of cardiomyocytes to their termini."
< "Q4U4S6-1","RefSeq","NP_001019789.1","17046827","Myomaxin functions directly downstream of MEF2A at the peripheral Z-disc complex in striated muscle potentially playing a role in regulating cytoarchitectural integrity"
< "Q4U4S6-1","RefSeq","NP_001019789.1","16500513","Upregulation due to Ang II-induced myocardial damage and not to blood pressure elevation per se"
---
> "Q61233-1","RefSeq","NP_032905.2","30244178","It is shown that TNF-alpha signaling regulates the phosphorylation of serine-5 and -7 in L-plastin which increases the actin bundling capacity of L-plastin and hence the formation of nascent sealing zones in mouse osteoclasts."
> "Q61233-1","RefSeq","NP_032905.2","27758872","The actin-bundling protein L-plastin (LPL) is required for the perinatal development of alveolar macrophages."
> "Q61233-1","RefSeq","NP_032905.2","27465533","Results identify L-plastin as a key effector of Mst1 and establish a novel mechanism linking a signaling intermediate to an actin-binding protein critical to T cell migration."
12426c16652,16656
< "Q3TY86-1","RefSeq","NP_001277999.1","19280713","AIF-deficient mice display similar rates of H2O2 release and protein carbonyl modifications in brain mitochondria compared to WT controls"
---
> "Q8R1R4-1","RefSeq","NP_083922.1","30573681","These results indicated a novel GRP78-dependent localization and specific function of IL-34 in FL-Y cells related to monocytic cell differentiation."
> "Q8R1R4-1","RefSeq","NP_083922.1","29664689","The IL-34 acts as a proinflammatory factor, aggravating the severity of arthritis in CIA mice by inducing the production of IL-17."
> "Q8R1R4-1","RefSeq","NP_083922.1","27865758","The current study aimed to assess the IL-34 expression in response to two members of the transforming growth factor (TGF)-beta family, TGF-beta1 and bone morphogenetic protein (BMP)-2, in synovial fibroblasts from rheumatoid arthritis patients."
> "Q8R1R4-1","RefSeq","NP_083922.1","21494622","This study was to explore the biological function, specifically osteoclastogenesis and bone metabolism, of il-34. Publication Status: Online-Only"
> "Q8R1R4-1","RefSeq","NP_083922.1","20504948","The different spatiotemporal expression of IL-34 and CSF-1 allows for complementary activation of the CSF-1R in developing and adult tissues."
12427a16658,16660
> "Q91ZM9-1","RefSeq","NP_084037.3","24551065","IGFBP-5 induces its pro-fibrotic effects, at least in part, via DOK5. IGFBP-5 and DOK5 are both increased in systemic sclerosis fibroblasts and tissues and may thus be acting in concert to promote fibrosis. Publication Status: Online-Only"
> "Q91ZM9-1","RefSeq","NP_084037.3","23954828","Dok5 is necessary for NT-3 signaling to block TrkC-induced apoptosis"
> "Q91ZM9-1","RefSeq","NP_084037.3","19800350","FOXO3a, the PI3K/PKB downstream substrate, acts as a transcriptional repressor to inhibit the expression of Dok-5."
12447a16681,16684
> "P00860-1","RefSeq","NP_038642.2","30217446","Findings indicated that ornithine decarboxylase (ODC1) was involved in attenuating the inflammatory response upon stimulation of macrophages, making it a potential therapeutic target for inflammatory diseases."
> "P00860-1","RefSeq","NP_038642.2","28096401","We demonstrate that ornithine decarboxylase (ODC) regulates M1 activation during Helicobacter pylori and Citrobacter rodentium infection. Deletion of Odc in macrophages resulted in increased inflammation and decreased bacterial persistence in mouse models. The enhanced M1 response was due to alterations in histone modifications, resulting in changes in chromatin structure and up-regulated transcription."
> "P00860-1","RefSeq","NP_038642.2","27770613","Ornithine decarboxylase (ODC) plays a key role in prostate tumorigenesis and that the polyamine pathway is altered as early as high-grade prostate intraepithelial neoplasia (HGPIN)."
> "P00860-1","RefSeq","NP_038642.2","27193233","These data support the hypothesis that TTP plays a role in the post-transcriptional regulation of the ODC mRNA transcript."
12457a16695
> "Q9DB07-1","RefSeq","NP_076320.2","17720815","The ciliary protein IFT46 has a specific function in chondrocytes and is also essential for normal development of vertebrates."
12483a16722,16723
> "Q8JZL7-1","RefSeq","NP_851835.1","28947785","The authors show that knockdown of the lipopolysaccharide (LPS)-induced cytoplasmic circular RNA, mcircRasGEF1B, results in altered expression of a wide array of genes. Pathway analysis revealed an overall enrichment of genes involved in cell cycle progression, mitotic division, active metabolism, and of particular interest, NF-kappaB, LPS signaling pathways, and macrophage activation. Publication Status: Online-Only"
> "Q8JZL7-1","RefSeq","NP_851835.1","20090772","Upon toll-like receptor activation, RasGEF1b may trigger Ras-like proteins and regulate specific biological activities of macrophages."
12486a16727,16730
> "O35316-1","RefSeq","NP_033346.2","29491220","Circulating levels of GDF15 were elevated in old slc6a6 knockout mice"
> "O35316-1","RefSeq","NP_033346.2","28572444","This study evaluated the role of taurine and its transporter on pancreatic islet cells and insulin secretion."
> "O35316-1","RefSeq","NP_033346.2","27444300","These findings suggest that TauT protein expression is relatively insensitive to changes in muscle taurine content in WT and mdx mice, and that taurine and beta-alanine supplementation may be viable therapeutic strategies to improve fatigue resistance of dystrophic skeletal muscle."
> "O35316-1","RefSeq","NP_033346.2","25629817","Both homozygous and heterozygous TauT gene deletion predispose C57BL/6 mice to develop end-stage diabetic kidney disease Publication Status: Online-Only"
12488a16733
> "Q8R0W1-1","RefSeq","NP_776096.2","25862660","MRNA expression profiles of core clock genes in the liver of Cipc (-/-) mice showed no significant differences from that in wild-type mice except for Per1"
12501c16746,16754
< "Q6ZPQ6-1","RefSeq","NP_001276401.1","26269578","Here we found that under high light intensities, RdgB2(-/-) mutant mice showed normal pupillary light responses and circadian photoentrainment"
---
> "Q9Z1K8-1","RefSeq","NP_035535.2","21264952","The expression of Mct8 and L-type amino acid transporters Lat2 and Lat1 are determined in brain neurons during development."
> "Q9Z1K8-1","RefSeq","NP_035535.2","19133747","LAT1, and LAT2 mRNAs were detected in fetal and postnatal femurs and in MC3T3-E1 cells, while OATP1 and NTCP mRNAs were not."
> "Q9Z1K8-1","RefSeq","NP_035535.2","18210381","System L functions as influx and/or efflux transport machinery displaying a greater propensity for the outward transport of large and small neutral amino acids."
> "Q9Z1K8-1","RefSeq","NP_035535.2","17376816","The Slc7a7(-/-) mouse displayed intrauterine growth restriction, leading to neonatal lethality. After heavy protein ingestion, the surviving adult animals presented metabolic derangement consistent with lysinuric protein intolerance."
> "Q9Z1K8-1","RefSeq","NP_035535.2","17003226","Selective regulation of SNAT3 and y(+)LAT1 expression may serve a major role in the renal adaptation to acid secretion and thus for systemic acid-base balance."
> "Q9Z1K8-1","RefSeq","NP_035535.2","15178563","Increased LAT1 expression can be induced by lipid oxidation products relevant to inflammatory responses in atherogenesis. LAT1 mediates lysophosphatidylcholine-enhanced cytokine production by endothelial cells. Erratum:[Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2425]"
> "Q7TQ62-1","RefSeq","NP_766462.2","15063725","Podn was characterized in cultured mouse cells."
> "Q9Z2E9-1","RefSeq","NP_032170.3","30552349","These findings provide further evidence that loss of Bscl2 in non-adipose tissues may contribute to the severity of metabolic dysfunction in this condition. Publication Status: Online-Only"
> "Q9Z2E9-1","RefSeq","NP_032170.3","29738274","Renal injury in Seipin-deficient lipodystrophic mice and its reversal by adipose tissue transplantation or leptin administration alone: adipose tissue-kidney crosstalk."
12505a16759,16763
> "Q5U4E2-1","RefSeq","NP_780308.2","27402271","Our study provides evidence that loss of Repin1 in db/db mice improves insulin sensitivity and reduces chronic hyperglycemia most likely by reducing fat mass and AT inflammation."
> "Q5U4E2-1","RefSeq","NP_780308.2","24760138","Our findings indicate that Repin1 plays a role in insulin sensitivity and lipid metabolism by regulating key genes of glucose and lipid metabolism."
> "Q5U4E2-1","RefSeq","NP_780308.2","20727851","A potential role for Repin1 as regulator of adipocyte size was shown.Repin1 seems to be involved in the regulation of genes involved in adipogenesis."
> "Q91WK0-1","RefSeq","NP_082018.1","23942110","LRRFIP2 inhibits NLRP3 inflammasome activation by recruiting the caspase-1 inhibitor Flightless-I, thus outlining a new mechanism for negative regulation of NLRP3 inflammasome."
> "Q91WK0-1","RefSeq","NP_082018.1","21220426","Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-like receptor 4 (TLR4)-mediated signaling."
12509a16768,16769
> "P35803-1","RefSeq","NP_075611.1","29282769","Study identified glycoprotein M6B as a Schwann cell microvilli component of peripheral nodes of Ranvier. Study detected Na(+) channel clusters at heminodes without any associated M6B, indicating that it is not required for initial channel clustering; showed that absence of M6B results in progressive appearance of nodal protrusions of the nodal axolemma, that are often accompanied by the presence of enlarged mitochondria."
> "P35803-1","RefSeq","NP_075611.1","24917275","The results of this study proposed that M6b proteins are required for proper extension and guidance of callosal axons that follow one of the most complex trajectories in the mammalian nervous system."
12521,12524d16780
< "Q8CIV7-1","RefSeq","NP_081200.2","30413481","Simultaneous deletion of Zeb1 encoding an EMT-promoting factor restores directional migration to Ovol2-deficient Bu-HFSCs. Taken together, our findings highlight the important function of an Ovol2-Zeb1 EMT-regulatory circuit in controlling the directional migration of epithelial stem and progenitor cells to facilitate adult skin epithelial regeneration and repair."
< "Q8CIV7-1","RefSeq","NP_081200.2","27310661","Association of a chromosomal rearrangement event with mouse posterior polymorphous corneal dystrophy and alterations in Csrp2bp, Dzank1, and Ovol2 gene expression have been reported. Publication Status: Online-Only"
< "Q8CIV7-1","RefSeq","NP_081200.2","26619963","OVOL2 is a colorectal tumor suppressor that blocks WNT signaling by facilitating the recruitment of histone deacetylase 1 to the TCF4-beta-catenin complex."
< "Q8CIV7-1","RefSeq","NP_081200.2","12213202","Ovol2 transcription was dramatically reduced in testes from blind-sterile mice, suggesting that Ovol2 is expressed in male germ cells"
12526a16783,16788
> "Q2EG98-1","RefSeq","NP_853522.2","21185261","These results demonstrate that Asp(523) in PKD2L1 is a key determinant of Ca(2+) permeation into the PKD1L3/PKD2L1 complex and that PKD2L1 contributes to forming the pore of the PKD1L3/PKD2L1 channel."
> "Q2EG98-1","RefSeq","NP_853522.2","19464260","PKD1L3-PKD2L1 channel activation by acetic acid was pH-dependent and occurred when the ambient pH was <3.1."
> "Q2EG98-1","RefSeq","NP_853522.2","18535624","The off-response property of PKD1L3-PKD2L1 channels might explain the physiological phenomena occurring during sour taste sensation."
> "Q2EG98-1","RefSeq","NP_853522.2","16891422","These results suggest that PKD1L3 and PKD2L1 heteromers may function as sour taste receptors."
> "Q2EG98-1","RefSeq","NP_853522.2","16805797","Pkd1l3 and Pkd2l1 are co-expressed in a select subset of taste receptor cells and therefore may, like other PKD channels, function as a heteromer"
> "Q2EG98-1","RefSeq","NP_853522.2","12782129","Genes are mapped to chromosomes and gene structures are characterized; protein structure is predicted and contains strong ion channel signature motifs that suggest their possible function as components of cation channel pores Erratum:[Genomics. 2003 Oct;82(4):498-500]"
12533a16796,16803
> "P97875-1","RefSeq","NP_112149.2","30217453","JDP2 role in the traumatic brain injury and cognitive function.JDP2 promoted caspase-3 activation in astrocytes."
> "P97875-1","RefSeq","NP_112149.2","29769710","JDP2 overexpression is associated with heart failure development. Publication Status: Online-Only"
> "P97875-1","RefSeq","NP_112149.2","28146118","JDP2 acts as a novel transcriptional activator of the mouse Mc2r gene, suggesting that JDP2 may have physiological functions as a novel player in MC2R-mediated steroidogenesis as well as cell signaling in adrenal glands. Publication Status: Online-Only"
> "P97875-1","RefSeq","NP_112149.2","12707301","Results suggest that Jun dimerization protein 2 (JDP2) may play an important role in the RANK-mediated signal transduction system, especially in osteoclast differentiation."
> "P97875-1","RefSeq","NP_112149.2","12225289","Characterization of binding sites for stress mitogen-activated protein kinases on JDP2"
> "P97875-1","RefSeq","NP_112149.2","12171923","JDP2 protein plays a major role in promoting skeletal muscle differentiation via its involvement in cell cycle arrest and activation of the myogenic program"
> "P97875-1","RefSeq","NP_112149.2","12052888","JDP2, repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells.JDP2 is key factor that controls the commitment of F9 cells to differentiation and shed light on AP-1 repressor functions"
> "Q9ET47-1","RefSeq","NP_997574.2","28516904","Findings suggest that Lhx1/5, through regulating Espin protein expression, control dendritogenesis and spine morphogenesis in postnatal Purkinje cells (PCs). Publication Status: Online-Only"
12534a16805,16815
> "Q99KY4-1","RefSeq","NP_705797.1","26345367","PTEN-like domains of GAK and auxilin are not essential for Hsc70-dependent chaperoning and uncoating of clathrin, but depending on the tissue, these domains appear to increase the efficiency of these co-chaperones."
> "Q99KY4-1","RefSeq","NP_705797.1","24138026","GAK knockout causes senescence and centrosome duplication in MEF cells."
> "Q99KY4-1","RefSeq","NP_705797.1","22022498","These results suggest that inhibition of GAK by gefitinib may cause pulmonary alveolar dysfunction."
> "Q99KY4-1","RefSeq","NP_705797.1","18434600","GAK deletion blocks development and causes lethality in adult animals by disrupting clathrin-mediated endocytosis"
> "Q6P2L6-1","RefSeq","NP_001295411.1","29101251","This study reveals a critical role of NSD3-mediated IRF3 methylation in enhancing antiviral innate immunity."
> "Q6P2L6-1","RefSeq","NP_001295411.1","28228401","WHSC1L1-L acts as a histone methyltransferase in podocytes and regulates nephrin gene expression, which may in turn contribute to the integrity of the slit diaphragm of the glomerular filtration barrier."
> "A2A432-1","RefSeq","NP_082564.3","30992047","CUL4B level mediates HOX gene expression via histone H2A ubiquitination.  Aberrant CUL4B-mediated H2AK119ub1 level may be a risk factor for neural tube defects. Publication Status: Online-Only"
> "A2A432-1","RefSeq","NP_082564.3","29106389","High CUL4B expression promotes gastric cancer invasion and metastasis."
> "A2A432-1","RefSeq","NP_082564.3","28604389","A cullin 4B-RING E3 ligase complex fine-tunes pancreatic delta cell paracrine interactions"
> "A2A432-1","RefSeq","NP_082564.3","17954973","Plays a conserved role in the regulation of beta-catenin levels."
> "A2A432-1","RefSeq","NP_082564.3","16052071","The cloning and expression of amino and carboxy-terminal halves of cullin4B in mouse PCC4 cells is reported."
12554a16836,16840
> "A2APV2-1","RefSeq","NP_765997.2","28852060","Our data thus link FMNL2/3 formins to actin assembly-dependent functions of Cdc42 in anterograde transport through the Golgi apparatus. Publication Status: Online-Only"
> "A2APV2-1","RefSeq","NP_765997.2","28327544","Force generation in lamellipodia strongly depends on FMNL formin activity. Publication Status: Online-Only"
> "A2APV2-1","RefSeq","NP_765997.2","24430873","FMNL1 and FMNL2 are required non-redundantly in the repair of damaged myofibrils."
> "A2APV2-1","RefSeq","NP_765997.2","22608513","FMNL2 is a novel elongation factor of actin filaments that constitutes the first Cdc42 effector promoting cell migration and actin polymerization at the tips of lamellipodia."
> "A2APV2-1","RefSeq","NP_765997.2","16490788","MDia1-FH2 has an effect on the conformation of actin filaments"
12568c16854,16859
< "Q9D552-1","RefSeq","NP_083124.1","16395525","Flow cytometry analysis showed that the expression of Spata17 protein in the GC-1 cell line could accelerate GC-1 cell apoptosis [Spata17]"
---
> "Q8VBT9-1","RefSeq","NP_937866.1","25944897","Insulin acts through TUG proteins to control IRAP targeting, similar to GLUT4; the activity of vasopressin, an IRAP substrate, is reduced in mice with disrupted TUG action in muscle."
> "Q8VBT9-1","RefSeq","NP_937866.1","25453902","A conditional expression in mice of the fusion gene ASPSCR1-TFE3 from human alveolar soft part sarcoma (ASPS) generated a model that recapitulates the human tumor histologically and by expression profile."
> "Q8VBT9-1","RefSeq","NP_937866.1","23744065","Data indicate that insulin stimulates proteolysis of TUG (tether containing a ubiquitin regulatory X (UBX) domain for glucose transporter 4 (GLUT4)) to translocate GLUT4 in muscle."
> "Q8VBT9-1","RefSeq","NP_937866.1","22610098","Data suggest a model whereby insulin stimulates TUG cleavage to liberate GLUT4 storage vesicles from the Golgi matrix, which promotes GLUT4 translocation to the cell surface and enhances glucose uptake."
> "Q8VBT9-1","RefSeq","NP_937866.1","17202135","Insulin-stimulated dissociation of TUG and GLUT4 as an important action by which insulin stimulates glucose uptake."
> "Q8VBT9-1","RefSeq","NP_937866.1","14562105","TUG traps endocytosed GLUT4 and tethers it intracellularly, and insulin mobilizes this pool of retained GLUT4 by releasing this tether"
12571a16863,16866
> "Q6A078-1","RefSeq","NP_666121.2","30446612","These findings indicate that antisense oligonucleotide treatment may represent a promising therapeutic approach for kidney disease in CEP290-associated ciliopathy syndromes."
> "Q6A078-1","RefSeq","NP_666121.2","17898177","CEP290 is a key mediator involved in G protein trafficking. The assessment of olfactory function can, therefore, serve as a useful diagnostic tool for genetic screening of certain syndromic ciliary diseases."
> "Q6A078-1","RefSeq","NP_666121.2","16632484","A CEP290/NPHP6 mutation perturbs its interaction with RPGR and results in early-onset retinal degeneration"
> "Q6A078-1","RefSeq","NP_666121.2","16682970","Identified mutations in the CEP290 gene in five families with variable neurological, retinal and renal manifestations"
12575a16871,16873
> "Q8BGQ7-1","RefSeq","NP_666329.2","29769718","Results identify an amino-acid-accepting co-regulator of tRNA synthetase editing, ANKRD16, as a new layer of the machinery that is essential to the prevention of severe pathologies that arise from defects in editing Erratum:[Nature. 2018 Aug;560(7720):E35. PMID: 29925958]"
> "Q8BGQ7-1","RefSeq","NP_666329.2","25422440","The pathological consequences of diminished tRNA synthetase editing activity, and thus translational infidelity, are dependent on the cell type and the extent of editing disruption"
> "Q8BGQ7-1","RefSeq","NP_666329.2","16906134","The mouse sticky mutation, which causes cerebellar Purkinje cell loss and ataxia, is a missense mutation in the editing domain of the alanyl-tRNA synthetase gene that compromises the proofreading activity of this enzyme during aminoacylation of tRNAs"
12576a16875,16878
> "Q91VL9-1","RefSeq","NP_848859.1","27542215","These results show that Zbtb1 expression prevents activation of a default myeloid program in LMPP cells, ensuring the generation of lymphoid cells"
> "Q91VL9-1","RefSeq","NP_848859.1","27402700","These results indicate that Zbtb1 prevents DNA damage in replicating immune progenitors, allowing the generation of B cells, T cells, and myeloid cells."
> "Q91VL9-1","RefSeq","NP_848859.1","22753936","Expression of mRNA encoding transgenic Zbtb1, a predicted transcription repressor, is greatest in hematopoietic stem cells, thymocytes, and pre-B cells, highlighting its essential role in lymphoid development"
> "Q91VL9-1","RefSeq","NP_848859.1","22201126","Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator."
12587,12590c16889,16891
< "Q9ESZ8-1","RefSeq","NP_001074215.1","31011227","Study provides molecular and cellular evidence for myelination deficits in Williams syndrome linked to neuronal deletion of Gtf2i. Erratum:[Nat Neurosci. 2019 Jul;22(7):1197. PMID: 31171854]"
< "Q9ESZ8-1","RefSeq","NP_001074215.1","30120731","Mice with a single copy of Gtf2i (Gtf2i(+/Del)) had increased axonal outgrowth and increased TRPC3-mediated calcium entry upon carbachol stimulation."
< "Q9ESZ8-1","RefSeq","NP_001074215.1","29568691","The results suggest a role for GTF2i in the hypersocial phenotype of WBS and more broadly in the regulation of social behavior. Support was not observed for the role of GTF2i in ASD. Publication Status: Online-Only"
< "Q9ESZ8-1","RefSeq","NP_001074215.1","27194223","The Cre-mediated deletion of exon 3 recapitulates a genetic null phenotype, indicating that the conditional Gtf2i line is a valuable tool for studying TFII-I function during embryonic development"
---
> "Q91W29-1","RefSeq","NP_444321.1","28620066","Cox4i2 is essential for acute but not chronic pulmonary oxygen sensing by triggering mitochondrial hyperpolarization."
> "Q91W29-1","RefSeq","NP_444321.1","17091399","Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex."
> "Q91W29-1","RefSeq","NP_444321.1","16981895","The presence of the COX isoform IV-2 suppresses the sensitivity of COX to its allosteric regulator ATP and overrules the regulation of COX by the cellular energy level"
12591a16893
> "Q9JL60-1","RefSeq","NP_064669.2","31175277","Gmeb1 knockdown in midbrain dopamine (mDA) neurons resulted in downregulation of tyrosine hydroxylase and dopamine transporter, as well as in severe motor deficits. This study thus identifies Gmeb1 as a master regulator of mDA gene expression and function. Publication Status: Online-Only"
12594d16895
< "Q8CG46-1","RefSeq","NP_001239613.1","28302748","Age-dependent depletion of the SMC5/6 complex in oocytes could contribute to increased incidence of oocyte aneuploidy and spontaneous abortion in aging females."
12601a16903,16905
> "Q9WTX6-1","RefSeq","NP_036172.1","27224922","Cul-1 deneddylation led to Deptor accumulation and subsequent mTOR inactivation, which had an inhibitory effect on dendritic cells in mouse model of inflammatory bowel disease. Erratum:[Oncotarget. 2018 Dec 18;9(99):37343. PMID: 30647874]"
> "Q9WTX6-1","RefSeq","NP_036172.1","27063938","Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response. Publication Status: Online-Only"
> "Q8VIM6-1","RefSeq","NP_536707.2","18849963","Stereocilin was detected in association with horizontal top connectors, lateral links that join adjacent stereocilia within the outer hair cell's hair bundle"
12603a16908
> "Q3UZ01-1","RefSeq","NP_080319.2","30254136","Our study, using a novel conditional mouse model of Rnpc3 deficiency, establishes that U12-dependent splicing is not only important during development but is indispensable throughout life."
12608a16914
> "P43431-1","RefSeq","NP_032377.1","30554110","IL-35 expression inhibited pulmonary inflammation and lung tissue lesions in cigarette smoke-treated animals."
12610a16917,16919
> "Q9D2W0-1","RefSeq","NP_387468.1","14976412","Corticosteroid hormone induced factor (CHIF) is a small epithelial-specific protein regulated by aldosterone and K+ intake."
> "Q9D2W0-1","RefSeq","NP_387468.1","12167609","Data are consistent with an effect of CHIF on the Na(+)-K(+)-ATPase specific to the outer and inner medullary duct"
> "Q8VCS3-1","RefSeq","NP_663388.1","27405802","FAM20B-catalyzed proteoglycans regulate postnatal endochondral ossification partially through the mediation of WNT signaling. Publication Status: Online-Only"
12620a16930,16931
> "Q3UPW2-1","RefSeq","NP_031947.1","27222093","ELF3 controls LCN2 expression in cooperation with NFkappaB."
> "Q3UPW2-1","RefSeq","NP_031947.1","11893733","Evidence that mElf-3, a member of the Ets family, plays a key role in the activation of the mTbetaR-II promoter."
12624a16936
> "D3YVL2-1","RefSeq","NP_083974.1","17971504","Ttc18 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
12636a16949
> "Q5U4E0-1","RefSeq","NP_808431.2","28978485","The results establish LHFPL4 as a synapse-specific tetraspanin essential for inhibitory synapse function and provide fresh insights into the molecular make-up of inhibitory synapses."
12640a16954,16962
> "Q8R0I0-1","RefSeq","NP_081562.2","30207087","Deletion of ACE2 induced the early manifestation of muscle weakness with signatures of muscle senescence. Angiotensin 1-7 improved muscle function in older mice, supporting future application of the peptide or its analogues in the treatment of muscle weakness in the elderly population."
> "Q8R0I0-1","RefSeq","NP_081562.2","29679094","ACE2 is a novel factor required for exercise-dependent modulation of adult neurogenesis and essential for serotonin metabolism."
> "Q8R0I0-1","RefSeq","NP_081562.2","29990483","High ACE2 expression is associated with acute lung injury."
> "Q8R0I0-1","RefSeq","NP_081562.2","29884907","We show sex dimorphism in the severity of diabetes- and ANGII-related renal lesions, and demonstrate that ACE2- and ACE-related compensatory mechanisms are sex-specific. Supporting our previous findings, the modulation and ANGII-mediated crosstalk between ACE2 and ACE in diabetic nephropathy progression was more evident in males."
> "Q8R0I0-1","RefSeq","NP_081562.2","15452268","Murine ACE2 less efficiently bound the S1 domain of SARS-CoV and supported less-efficient S protein-mediated infection."
> "Q8R0I0-1","RefSeq","NP_081562.2","12487024","ACE2 gene is expressed mainly in the kidney and the lungs."
> "Q8R0I0-1","RefSeq","NP_081562.2","12075344","Angiotensin-converting enzyme 2 is an essential regulator of heart function."
> "P24721-1","RefSeq","NP_031519.1","27405760","The key roles of the ManR and ASGR in controlling circulating levels of numerous glycoproteins critical for regulating reproductive hormones and blood coagulation."
> "P24721-1","RefSeq","NP_031519.1","21656538","Found that the asialoglycoprotein receptor (ASGPR) is involved in hepatocyte recognition of cells predestined for killing, including activated autologous T lymphocytes"
12641a16964,16968
> "P15530-1","RefSeq","NP_032365.1","29141870","Ablation of B cell antigen receptor ubiquitination in vivo uncouples the receptor from CD19 phosphorylation and phosphatidylinositol 3-kinase (PI3K) signals."
> "P15530-1","RefSeq","NP_032365.1","25471597","B-cell inhibition by cross-linking CD79b is superior to B-cell depletion with anti-CD20 antibodies in treating murine collagen-induced arthritis."
> "P15530-1","RefSeq","NP_032365.1","24548411","The cytoplasmic tail of IgG1 is strictly required for the surface expression of IgG1 when the expression of Iga/Igb heterodimer is down-regulated in B lymphoma."
> "O54918-1","RefSeq","NP_997564.1","30590105","Bim is expressed in dopaminergic neurons and contributes to parkinsonian neurodegeneration. The transcriptional activation of Bim by c-Jun promotes MPTP-induced nigral dopaminergic neuron death. This study is significant because it precisely demonstrates a pro-death role of c-Jun/Bim upregulation in nigral dopaminergic neurons by using cell type-specific knockout mice."
> "O54918-1","RefSeq","NP_997564.1","30610162","Fas and Bim both function to regulate T cell apoptosis in early stages of viral infections and during costimulation blockade."
12648a16976,16977
> "Q6NSU3-1","RefSeq","NP_083902.2","29483533","GLT8D1 and CSNK2B knockdown promote the proliferation and inhibit the differentiation abilities of neural stem cells, and alter morphology and synaptic transmission of mouse neurons. Erratum:[Nat Commun. 2018 Nov 16;9(1):4905. PMID: 30446647] Publication Status: Online-Only"
> "Q5M956-1","RefSeq","NP_598873.2","28818080","The main pathological phenotype of the Kctd1 (I27N) heterozygous mutant mice consists of kidney dysfunction and secondary effects thereof, without gross additional primary alterations in the other phenotypic parameters analyzed. Publication Status: Online-Only"
12654a16984,16990
> "Q60668-1","RefSeq","NP_031542.2","30429285","In this study, AUF1, was posttranslationally destabilized to bring about activation of BMP signaling and wound healing during Candida albicans infection"
> "Q60668-1","RefSeq","NP_031542.2","30418981","Study identified RANKL and BCL6 mRNA as targets of AUF1 p42. Detailed analysis of 3'UTRs revealed for both that full instability required two elements, which are conserved in evolution. In RANKL mRNA both elements are AU-rich and separated by 30 bases, while in BCL6 mRNA one is AU-rich and 60 bases from a non-AU-rich element that potentially forms a stem-loop structure. Publication Status: Online-Only"
> "Q60668-1","RefSeq","NP_031542.2","27784781","These results suggest that the post-transcriptional regulation of ATX expression by HuR and AUF1 modulates cancer cell migration."
> "Q60668-1","RefSeq","NP_031542.2","27452471","Control of ARE-mRNA decay by AUF1 represents a mechanism for adult stem cell regulation."
> "Q60668-1","RefSeq","NP_031542.2","24891619","MEF2C is a key effector of the myogenesis program promoted by AUF1."
> "Q60668-1","RefSeq","NP_031542.2","14715706","AUF1 p40, HuR, and the 3'UTR of the CTR mRNA transcript could be involved in posttranscriptional regulation of CTR mRNA expression."
> "Q60668-1","RefSeq","NP_031542.2","12107167","Interaction with lactate dehydrogenase"
12658a16995,16999
> "Q8K0X8-1","RefSeq","NP_898994.2","28928414","Loss of HDAC11 had no obvious impact on brain morphology and neural stem/precursor cells isolated from Hdac11 (KO/KO) mice had comparable proliferation and differentiation characteristics. However, in differentiating neural cells this study observed decreased expression of schizophrenia-associated gene Fez1. Publication Status: Online-Only"
> "Q8K0X8-1","RefSeq","NP_898994.2","27247180","Phosphorylation of FEZ1 by MARK regulates its function in presynaptic protein trafficking. Publication Status: Online-Only"
> "Q8K0X8-1","RefSeq","NP_898994.2","24726361","Dendrite growth depends on degradation of FEZ1 regulated by Cdc20/APC."
> "Q8K0X8-1","RefSeq","NP_898994.2","18647754","Investigated the role of FEZ1 in brain development and the pathogenesis of schizophrenia by generating mice that lack Fez1"
> "Q8K0X8-1","RefSeq","NP_898994.2","15579145","Fez1 is mainly expressed in cortical layers V and VI, not in gamma-aminobutyric acid neurons but in pyramidal neurons, the projection neurons of the cerebral cortex. Immunohistochemistry also shows that Fez1 is expressed in deep layers of the neocortex."
12676a17018,17021
> "Q8C7H1-1","RefSeq","NP_598584.2","23022071","The mouse methylmalonic aciduria- related genes, Mmaa, Mmab, and Mut may have specialized functions depending on the tissue or cell type."
> "Q91V12-1","RefSeq","NP_579926.2","28416579","Downstream effects of LPS-induced induction of ACOT7 and its role in inflammatory settings in myeloid cells"
> "Q91V12-1","RefSeq","NP_579926.2","26861785","Data (including data from studies in transgenic mice) suggest that up-regulation of Acot7 expression in clonal beta-cells impairs insulin secretion in response to glucose plus free fatty acids; expression of Acot7 is ubiquitous across tissues but relatively silenced/disallowed in pancreatic beta cells."
> "Q91V12-1","RefSeq","NP_579926.2","11834298","MBACH cDNA encoded a 338-AA pp >95% identical to human and rat homologs. mBACH was distributed throughboth central and peripheral cell body and neurites. Another 50-kDa pp made from mBACH mRNA used different in-frame ATGs as initiation codon."
12678a17024,17025
> "Q00422-1","RefSeq","NP_032091.2","29051483","Depletion of GABPalpha impairs T-cell homeostatic survival, proliferation, and antigen-induced responses in vivo. Publication Status: Online-Only"
> "Q00422-1","RefSeq","NP_032091.2","26185160","GABPalpha Binding to Overlapping ETS and CRE DNA Motifs Is Enhanced by CREB1 Publication Status: Online-Only"
12679a17027
> "Q8C7I4-1","RefSeq","NP_776104.1","24453359","Authors identified a new antiviral protein induced by interferon, ApoL9b, whose lack of expression in primary neurons likely contributes to the high sensitivity of these cells to viral infection."
12681a17030,17035
> "Q8BG99-1","RefSeq","NP_683752.2","23717575","Results indicated that Pknox2 misexpression affected mesenchymal condensation and early chondrogenic differentiation in the zeugopod skeletons of transgenic embryos Publication Status: Online-Only"
> "Q8BG99-1","RefSeq","NP_683752.2","15339927","Transcriptional regulation by PREP2 is modulated through the subcellular distribution of multiple isoforms and by interaction with two distinct cytoskeletal systems"
> "Q8BG99-1","RefSeq","NP_683752.2","12412021","Prep2 functions to varying degrees in a broad array of tissues and developmental processes."
> "O08858-1","RefSeq","NP_035555.1","25149275","The expression and localization of the three receptors (SSTR3-SSTR5) in wild-type (WT), single-knockout (SSTR1 KO) and double-knockout SSTR1/SSTR2 (DKO) mice, are reported."
> "O08858-1","RefSeq","NP_035555.1","24523912","Mouse somatostatin receptor 5 is sorted by a network of PDZ-domain containing proteins Publication Status: Online-Only"
> "O08858-1","RefSeq","NP_035555.1","23831358","Findings suggest that somatostatin and its receptors (SSTR2 and SSTR5) are important markers in the regulation and development of Sertoli cell."
12693a17048,17050
> "Q8BK03-1","RefSeq","NP_780601.1","28938432","The ovarian phenotypes of these mice suggested that the MIGA1/2 proteins play an important role in ovulation and ovarian steroidogenesis. In vivo and in vitro analyses of Miga1/2-knockout granulosa cells showed severe defects in luteinization and steroidogenesis and disordered mitochondrial morphology and function in response to gonadotropins."
> "Q8BK03-1","RefSeq","NP_780601.1","26716412","Data indicate that mitoguardin (Miga) knoskout Miga1/2-/- females show greatly reduced quality of oocytes and early embryos and are subfertile."
> "Q8BK03-1","RefSeq","NP_780601.1","26711011","Propose that MIGA1/2 proteins promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD."
12712a17070,17071
> "Q8R3V5-4","RefSeq","NP_647463.1","28455444","Data (including data from studies in knockout mice) suggest that Sh3glb2 regulates trafficking of endocytic vesicles and autophagosomes to late endosomes or lysosomes; despite having an intracellular localization and tissue distribution similar to endophilin B1, endophilin B2 is dispensable for mitochondrial apoptosis."
> "Q8R3V5-4","RefSeq","NP_647463.1","18303116","The immunodominant SPAS-1 epitope SNC9-H(8) arose from a point mutation in one allele of the gene in transgenic adenocarcinoma of mouse prostate tumor cells"
12719a17079,17080
> "P70699-1","RefSeq","NP_032090.3","28336814","GAA enzyme deficiency leads to glycogen accumulation in the trachea and bronchi and impairs the ability of lower airway smooth muscle to regulate calcium and respond appropriately to bronchodilator or constrictors."
> "P70699-1","RefSeq","NP_032090.3","27614205","The data unequivocally confirm that systemic absence of GAA induces a complex neuropathological cascade in the spinal cord."
12737a17099
> "Q8C7U7-1","RefSeq","NP_766039.2","10464263","This paper describes the identification and cloning of the orthologous human enzyme of mouse UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6."
12741,12744c17103,17108
< "Q8BG60-1","RefSeq","NP_001009935.1","30138646","This study showed that the thioredoxin-interacting protein in brain increase after exposed to chronic stress."
< "Q8BG60-1","RefSeq","NP_001009935.1","30168649","TXNIP regulates cellular senescence by inhibiting AKT pathways via a direct interaction under conditions of glucose-derived metabolic stress."
< "Q8BG60-1","RefSeq","NP_001009935.1","30142540","TXNIP facilitates the oxidative stress response in glomerular mesangial cells partially through AMPK pathway."
< "Q8BG60-1","RefSeq","NP_001009935.1","29884908","Our study suggests that TXNIP plays a key role in the renal inflammation and fibrosis induced by unilateral ureteral obstruction. The expression of TXNIP was increased in a time-dependent manner in the ligated kidneys."
---
> "Q9CQU3-1","RefSeq","NP_080671.1","30260951","Study in knockout mice and genetically modified human HAP1 cell line suggests that Rer1 maintains Notch signaling by maintaining sufficient expression of the gamma-secretase complex on the cell surface and regulating neural stem cell maintenance during cerebral cortex development. Publication Status: Online-Only"
> "Q9CQU3-1","RefSeq","NP_080671.1","28117367","Rer1 controls the assembly and transport of Nav1.1 and 1.6, the principal sodium channels responsible for recurrent firing, in Purkinje cells. Publication Status: Online-Only"
> "Q9CQU3-1","RefSeq","NP_080671.1","21187406","Rer1 is a functionally important unique factor that controls surface expression of muscle acetylcholine receptors by localizing unassembled alpha-subunits to the early secretory pathway"
> "Q3UFK8-1","RefSeq","NP_080445.1","29776906","Results suggest that blood entering the joint activates the iRhom2/ADAM17/TNF-alpha pathway, thereby contributing to osteopenia and synovitis in mice."
> "Q3UFK8-1","RefSeq","NP_080445.1","29897336","FRMD8 promotes inflammatory and growth factor signaling by stabilizing the iRhom2/ADAM17 sheddase complex. Publication Status: Online-Only"
> "Q3UFK8-1","RefSeq","NP_080445.1","29897333","ITAP (FRMD8) is a novel iRhom2 interactor that controls TNF-alpha secretion by policing the stability of iRhom2/ADAM17 complex. Publication Status: Online-Only"
12775a17140
> "Q80XM3-1","RefSeq","NP_080010.2","27677211","Targeted deletion of Kv6.4 in a transgenic mouse model causes male sterility as offspring from homozygous females were only obtained after mating with wild-type or heterozygous males. sterility of the homozygous males was caused by a severe reduction in total sperm-cell count and the absence of motile spermatozoa in the semen. spermatozoa of homozygous mice showed an abnormal morphology, with smaller head and shorter tail"
12787a17153,17156
> "O54707-1","RefSeq","NP_034784.1","30535636","Data suggest that the Cd94(LocA)/NKG2A receptor (NKG2A) heterodimeric receptor is widely expressed among M. musculus subspecies musculus."
> "O54707-1","RefSeq","NP_034784.1","25520036","Segregation of a spontaneous Klrd1 mutation in DBA/2 mouse substrains Publication Status: Online-Only"
> "O54707-1","RefSeq","NP_034784.1","22084441","The transmembrane region sequences of CD94 and NKG2 in mouse and rat differ markedly from other mammalian orthologs by the presence of a lysine residue in the transmembrane region."
> "O54707-1","RefSeq","NP_034784.1","21540458","The complex interplay between various stimuli may account for the variable expression of CD94/NKG2A during responses to different pathogens in vivo."
12789a17159,17163
> "Q99LI8-1","RefSeq","NP_032270.3","27112194","Findings find that Hrs is indispensable for the autophagic clearance of neurodegeneration-related proteins and for the survival of hippocampal neurons in mammals. In particular, the work provides the novel insight that the loss of Hrs results in insufficient autophagic clearance and enhanced ER stress, thereby triggering JNK activation and subsequent apoptotic and necroptotic neuronal cell death. Publication Status: Online-Only"
> "Q99LI8-1","RefSeq","NP_032270.3","26115514","HGS expression in the nervous system is developmentally regulated.HGS is required for motor neuron function. Publication Status: Online-Only"
> "Q99LI8-1","RefSeq","NP_032270.3","26078721","Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility. Publication Status: Online-Only"
> "Q99LI8-1","RefSeq","NP_032270.3","25296754","ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation. Erratum:[J Biol Chem. 2015 Mar 27;290(13):8065-6. PMID: 25819836]"
> "Q99LI8-1","RefSeq","NP_032270.3","24246674","These results indicate that Hrs plays important roles during peripheral development and physiological functions of B lymphocytes."
12796a17171,17178
> "Q99PF4-1","RefSeq","NP_075859.2","30033219","Crystal structures showing 18 CDH23 extracellular cadherin (EC) repeats, including the most and least conserved, a fragment carrying disease mutations, and EC repeats with non-canonical Ca(2+)-binding motif sequences and unusual secondary structure. Deafness mutations' effects on stability and affinity for Ca(2+). Additionally, contiguous CDH23 EC repeats reveals helicity and potential parallel dimerization faces."
> "Q99PF4-1","RefSeq","NP_075859.2","29486248","Data indicate that cadherin 23 (CDH23) EC1+2 from the erl mice showed less Ca(2+)-dependent proteolysis protection comparing with that of the wild type control."
> "Q99PF4-1","RefSeq","NP_075859.2","29261728","Interactions of wild type (WT) and mutant variants of N-terminal fragments (EC1+2) of cadherin-23 and protocadherin-15, two proteins essential for inner-ear mechanotransduction, are reported. Publication Status: Online-Only"
> "Q8CGN5-1","RefSeq","NP_783571.2","30042231","Plin1 is required to restrain fat loss and pro-inflammatory responses in adipose tissue by reducing futile lipolysis to maintain metabolic homeostasis."
> "Q8CGN5-1","RefSeq","NP_783571.2","29407594","Overexpressed PLIN1 in macrophages had a protected role against atheroma progression in ApoeKO in the absence of changes in gonadal fat mass or plasma lipid levels, presumably due to modification of the stability and/or inflammatory profile of macrophages."
> "Q8CGN5-1","RefSeq","NP_783571.2","29191637","This mouse model might mimic and explain the pathogenesis of hepatosteatosis occurring in two typical disorders of adipose tissue dysfunction, obesity and lipodystrophy, particularly in lipodystrophic patients with Plin1 mutation."
> "Q8CGN5-1","RefSeq","NP_783571.2","12407111","The central 25% of the perilipin A sequence contains all of the amino acids necessary to target and anchor the protein to lipid droplets"
> "Q8CGN5-1","RefSeq","NP_783571.2","11751901","Perilipin expression and phosphorylation state are critical regulators of lipid storage and hydrolysis in ACS1/FATP1 cells."
12832a17215,17223
> "P22091-1","RefSeq","NP_035657.1","30560907","Study reveals a complex pattern of gene regulation by SCL, ETO2 and RYBP. Genome-wide analyses shows locus-specific binding of ETO2 and RYBP on SCL's 778 activated and repressed genes. Publication Status: Online-Only"
> "P22091-1","RefSeq","NP_035657.1","29151585","Ectopic expression of the TAL1 transcription factor and Pten deletion are bona-fide cooperating events."
> "Q8K2C7-1","RefSeq","NP_808282.2","26721884","Data suggest renal cell lines exhibit an OS9-mediated ERAD (endoplasmic reticulum-associated degradation) pathway that degrades Nkcc2/Slc12a1 (solute carrier family 12 member 1) prior to glycosylation/processing."
> "Q8K2C7-1","RefSeq","NP_808282.2","21523322","The depletion of OS-9 in 3T3-L1 adipocytes impaired cell function in terms of triacylglycerol storage, and slightly influenced cell differentiation."
> "Q8K2C7-1","RefSeq","NP_808282.2","17932042","OS-9 regulates the secretory transport of TRPV4 and appears to protect TRPV4 subunits from the precocious ubiquitination and ER-associated degradation."
> "Q8CDU6-1","RefSeq","NP_766225.2","26157031","Studies describe an unreported innate immune pathway and suggest that mutation or antagonism of the E3 ligase HECTD2 results in reduced severity of lung inflammation by selectively modulating the abundance of the anti-inflammatory protein PIAS1"
> "Q8CDU6-1","RefSeq","NP_766225.2","19214206","Hectd2 is identified as a quantitative trait gene for prion disease incubation time in mice."
> "Q64685-1","RefSeq","NP_666045.1","30294329","Study in St6gal1 knockout mice observed that B cell-intrinsic St6gal1 is required for marginal zone B cell development, while B cell non-autonomous St6gal1 modulates B cell development and survival at the early transitional stages of the marrow and spleen. Publication Status: Online-Only"
> "Q64685-1","RefSeq","NP_666045.1","30006781","MiR-9 inhibits the metastatic ability of hepatocellular carcinoma via targeting ST6Gal-I."
12842a17234,17239
> "Q0VBN2-1","RefSeq","NP_001074785.1","26488883","Data show that dermatan sulfate is completely absent in dermatan sulfate epimerase 1 and 2 double knockout (DKO) mice. Publication Status: Online-Only"
> "Q0VBN2-1","RefSeq","NP_001074785.1","23843960","DS-epi1 deficiency results in a major reduction of iduronic acid both on cell surface and in secreted CS/DS proteoglycans and affects directional migration of aortic smooth muscle cells. Publication Status: Online-Only"
> "Q0VBN2-1","RefSeq","NP_001074785.1","22496542","DS-epi2-deficient mice showed no anatomical, histological or morphological abnormalities and DS-epi1 likely compensates in vivo for the loss of DS-epi2"
> "Q0VBN2-1","RefSeq","NP_001074785.1","21177331","The iduronic acid-containing structures in the developing brain are mainly produced by the actions of dermatan sulfate epimerase 2 and play crucial roles in postnatal development"
> "Q0VBN2-1","RefSeq","NP_001074785.1","20358601","DSEL was selected for study in 125 patients with diaphragmatic hernias, as it is involved in the synthesis of decorin, a protein that is required for normal collagen formation and that is upregulated during myogenesis."
> "Q8K2H6-1","RefSeq","NP_081180.1","22190705","ANAPC10 was mainly expressed in the cytoplasm of spermatogonia and leptotene and pachytene spermatocytes. Publication Status: Online-Only"
12854a17252,17263
> "Q04863-1","RefSeq","NP_033072.2","30445013","RELB is required for the ductular reaction and development of biliary fibrosis in CyldDLPC mice. Deletion of RELB and CYLD from LPCs protects mice from DDCinduced cholestatic liver fibrosis."
> "Q04863-1","RefSeq","NP_033072.2","29730722","Results indicate an epithelial intrinsic role of transcription factor RelB (RelB) on medullary thymic epithelial cells (mTECs) development and function."
> "Q04863-1","RefSeq","NP_033072.2","30037996","Eda-activated RelB recruits BAF complex to specific gene loci for local chromatin remodeling of target genes."
> "Q04863-1","RefSeq","NP_033072.2","29485182","These results show that RelB in dendritic cells is important for Th2 induction by regulating the development of CD117+CD172a+ dendritic cells and for the priming of allergic pulmonary hyperreactions"
> "Q3TJ91-1","RefSeq","NP_663413.2","21606200","Data suggest that mammalian Llgl2 is required for proper polarized invasion of trophoblasts and efficient branching morphogenesis during placental development, but, unlike its Drosophila ortholog, it does not function as a canonical tumor suppressor gene."
> "P58710-1","RefSeq","NP_848862.1","30219227","Gulo promotes the mesenchymal-to-epithelial transformation and apoptosis, and inhibits proliferation in metanephric mesenchyme cells by down-regulating Six2."
> "P58710-1","RefSeq","NP_848862.1","15674730","Demonstrated that the sfx mutation involved in spontaneous bone fracture in the murine system is a result of a large deletion in the gene for L-gulonolactone oxidase on mouse Chromosome 14"
> "Q3TRM4-1","RefSeq","NP_056616.2","20112100","The expression of CaMKIIalpha and pCREB exhibits a significant increase in cortex and hippocampus after treatment with PFOS, compared with the control."
> "Q3TRM4-1","RefSeq","NP_056616.2","19524041","We conclude that spongiform pathology in conditional NTE knockout mice is not mediated by PrPc, and that tubulovesicular inclusions can be seen in spongiform encephalopathy of other etiologies and are not pathognomonic of prion disease"
> "Q3TRM4-1","RefSeq","NP_056616.2","17015841","Increase of neuropathy target esterase (NTE) expression contributes to increased production and accumulation of glycerophosphocholine in mammalian renal cells in tissue culture and in vivo."
> "Q3TRM4-1","RefSeq","NP_056616.2","12805562","Mouse brain neuropathy target esterase is a lysophospholipase"
> "Q3TRM4-1","RefSeq","NP_056616.2","12640454","NTE has a role in neural development and in the neurodegeneration induced by organophosphate compounds in mice"
12893,12894d17301
< "O08795-1","RefSeq","NP_001280580.1","22337885","TRIM67 regulates Ras signaling via degradation of 80K-H, leading to neural differentiation including neuritogenesis."
< "O08795-1","RefSeq","NP_001280580.1","21995826","Data demonstrate the presence of a binding site on the 3'-untranslated region of NR1 mRNA for AnxA2 and show the regulation of NR1 mRNA by AnxA2, GIIbeta and a third NR1 mRNA-binding protein, which is yet to be identified."
12898a17306,17310
> "Q7TNT2-1","RefSeq","NP_848912.1","30372477","Far2 null mice provide further support for a central role for chronic sebadenitis in the development of a number of cicatricial alopecias. The Meibomian and clitoral glands (modified sebaceous glands) showed ducts dilated to various degrees that were associated with mild changes in the sebocytes as seen in the truncal skin. Publication Status: Online-Only"
> "Q7TNT2-1","RefSeq","NP_848912.1","29652635","Results indicate fatty acyl CoA reductase 2 FAR2's role in the development of mesangial matrix expansion and chronic kidney disease."
> "Q7TNT2-1","RefSeq","NP_848912.1","24009241","Mouse strains with mesangial matrix expansion contain a 9-bp sequence in the 5' untranslated region of Far2 that is absent in most of the strains without it."
> "Q7TNT2-1","RefSeq","NP_848912.1","15220349","Wax monoester synthesis in mammals involves a two step biosynthetic pathway catalyzed by fatty acyl-CoA reductase and wax synthase enzymes"
> "Q7TNT2-1","RefSeq","NP_848912.1","15220348","Fatty alcohol synthesis in mammals is accomplished by two fatty acyl-CoA reductase isozymes that are expressed at high levels in tissues known to synthesize wax monoesters and ether lipids"
12901a17314,17323
> "P97799-1","RefSeq","NP_033539.1","26430118","In behavioral analyses, overexpressing Nrsn1, one of the newly identified genes undergoing rapid translational repression, or activating ESR1 in the hippocampus impaired memory formation."
> "P97799-1","RefSeq","NP_033539.1","17566649","The results of this study indicate that Nrsn1 plays an active role in axonal regeneration as well as in embryonic development."
> "P97799-1","RefSeq","NP_033539.1","16696124","Neurensin-1 plays a role in the fiber extension of the retinal neurons, and indicate that the developing retina is a suitable experimental model for the analysis of Neurensin function, both in vivo and in vitro."
> "P97799-1","RefSeq","NP_033539.1","16527258","Neurensin-2 was expressed in small vesicles including lysosomes in the perinuclear region. And was found in cell bodies."
> "Q91WA4-1","RefSeq","NP_598448.1","28416650","Recruits DNA demethylase Tet2 to regulate TLR7/9-elicited interferon response in plasmacytoid dendritic cells"
> "Q91WA4-1","RefSeq","NP_598448.1","27932247","Data show that the peptide binding pocket of the Dishevelled 1 (Dvl1) PDZ domain is stabilized upon CXXC finger 5 protein (CXXC5) binding."
> "Q91WA4-1","RefSeq","NP_598448.1","26944478","Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms."
> "Q91WA4-1","RefSeq","NP_598448.1","26462610","The finding of this study indicate that the regulation of myelin genes expression by CXXC5 is important for forming myelin structure involved with axonal electrical signal transfer in the corpus callosum."
> "Q91WA4-1","RefSeq","NP_598448.1","26056233","The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing."
> "Q91WA4-1","RefSeq","NP_598448.1","24136587","CXXC5 is a transcriptional activator for Flk-1, mediating BMP signaling for differentiation and migration of endothelial cell and vessel formation."
12905a17328,17333
> "E9Q238-1","RefSeq","NP_852069.4","29217769","KANK1 binds to KIF21A through ankyrin repeat."
> "E9Q238-1","RefSeq","NP_852069.4","29158259","Several key residues (i.e. Thr-1147, Leu-1152, Leu-1153, and Tyr-1154) at the C-terminal half of the KIF21A KBD peptide contact with the hydrophobic patch formed by Tyr-1176, Met-1209, Leu-1210, Leu-1213, and Leu-1248 from KANK1."
> "Q8BX05-1","RefSeq","NP_796326.1","28607088","GK5 formed a complex with the sterol regulatory element-binding proteins (SREBPs) through their C-terminal regulatory domains, inhibiting SREBP processing and activation."
> "Q3UHD6-1","RefSeq","NP_083997.1","29180720","This study broadens our understanding of SNX27 as an integrator of lipid-based signals with the control of transcription and metabolic pathways. Publication Status: Online-Only"
> "Q3UHD6-1","RefSeq","NP_083997.1","27974614","We anticipate that future study will determine whether modulation of a SNX27/Notch/gamma-secretase pathway can also be of therapeutic interest to congenital hydrocephalus"
> "Q3UHD6-1","RefSeq","NP_083997.1","15466885","SNX27 and NHERF specifically interact with the 5-HT4a receptor splice variant"
12912a17341,17344
> "Q3U7U3-1","RefSeq","NP_694875.2","27915416","Fbxo7-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 levels. These studies reveal differential cell cycle regulation by Fbxo7 at different stages in T-cell development."
> "Q3U7U3-1","RefSeq","NP_694875.2","27497298","Taken together, this study establishes a vital role for FBXO7 in neurons, which is required for proper motor control and accentuates the importance of FBXO7 in proteasome function."
> "Q3U7U3-1","RefSeq","NP_694875.2","21652635","The physiological effect of reduced levels of Fbxo7 in mice showed significantly increased pro-B cell and pro-erythroblast populations, consistent with Fbxo7 having an anti-proliferative function and/or a role in promoting maturation of precursor cells."
> "Q3U7U3-1","RefSeq","NP_694875.2","16096642","Fbxo7 specifically regulated D cyclin/cdk6 complexes; it was highly expressed in epithelial tumors, but not in normal tissues, suggesting that it may have a proto-oncogenic role in human cancers."
12926,12927d17357
< "Q8BPM6-1","RefSeq","NP_001033713.1","27129882","Regulation of expression level and splicing of RIC-3 in brain and in immune cells following inflammation enables regulation of nicotinic acetylcholine receptor functional expression. Publication Status: Online-Only"
< "Q8BPM6-1","RefSeq","NP_001033713.1","20668195","In neurons, Ric-3 ER retention appears to promote transport within the dendritic ER subcompartment, thereby restricting 7 trafficking to dendrites and preventing axonal transport."
12933,12935d17362
< "Q8CHD8-1","RefSeq","NP_001156340.1","24576489","Results suggest that FIP3 regulates dendritic formation in the hippocampus possibly through Rab11- and Arf6-mediated endosomal trafficking"
< "Q8CHD8-1","RefSeq","NP_001156340.1","20736163","CART1 might be a cytoplasmic, testis-specific derepressor of RAR [CART1, cytoplasmic adaptor for RAR and TR]"
< "Q8CHD8-1","RefSeq","NP_001156340.1","15601896","Fip3 and Rab11 protein complex regulates recycling endosomes targeting to the cleavage furrow during late cytokinesis."
12939a17367,17378
> "Q9ERI2-1","RefSeq","NP_076124.1","30967557","Comparing protein profiles between KIBRA knockout and wild-type mouse brain showed significantly decreased Rab27a. Rab27a is stabilized by interacting with KIBRA, which prevents ubiquitination and degradation via the ubiquitin-proteasome pathway. Publication Status: Online-Only"
> "Q9ERI2-1","RefSeq","NP_076124.1","29712939","A3 directly interacted with the GDP-bound forms of Rab7 and Rab27A. These findings reveal a novel role for the proton pump V-ATPase in secretory lysosome trafficking and an unexpected mechanistic link with Rab GTPases. Publication Status: Online-Only"
> "Q9ERI2-1","RefSeq","NP_076124.1","17090228","Rab27a and JFC1/Slp1 permit myeloperoxidase release into the surrounding milieu and constitute key components of the secretory machinery of azurophilic granules in granulocytes"
> "Q9ERI2-1","RefSeq","NP_076124.1","12122117","Rab27b is functionally redundant with Rab27a and the pathogenesis of Griscelli syndrome is determined by the relative expression of Rab27a and Rab27b in specialized cell types. Erratum:[J Clin Invest 2002 Oct;110(8):1213]"
> "Q9DD06-1","RefSeq","NP_082128.1","30576947","Findings show that chemerin-activated CMKLR1 regulation in inflammatory macrophages is largely GRK6 and beta-arrestin mediated, which may impact innate immunity and have therapeutic implications in rheumatic disease."
> "Q9DD06-1","RefSeq","NP_082128.1","29715085","Systemic and hepatic chemerin, and chemerin receptor activation were not changed in hepatocellular carcinoma. Chemerin protein was induced in liver in NASH, but was unchanged in HCC tissues.  Hepatic and serum chemerin and ex vivo analyzed chemerin receptor activation do not differ in murine NASH-associated HCC when compared to NASH."
> "Q9DD06-1","RefSeq","NP_082128.1","29414326","Total serum chemerin levels and ex vivo CMKLR1 and GPR1 activation were significantly induced in high fat diet."
> "Q9DD06-1","RefSeq","NP_082128.1","27461525","Endogenously secreted chemerin plays an autocrine/paracrine role in white adipose tissue, identifying chemerin as a therapeutic target to modulate adipose remodelling."
> "Q9DD06-1","RefSeq","NP_082128.1","18242188","These data establish that chemerin is a novel adipokine that regulates adipocyte function."
> "Q9DD06-1","RefSeq","NP_082128.1","17767914","Thus, the adipokine chemerin likely regulates adipocyte function by autocrine/paracrine mechanisms."
> "Q9DD06-1","RefSeq","NP_082128.1","17640997","Rarres2 is highly expressed in adipose tissue and during adipocyte differentiation."
> "Q9DD06-1","RefSeq","NP_082128.1","17635925","Chemerin is a novel adipose-derived signaling molecule that regulates adipogenesis and adipocyte metabolism"
12944a17384,17385
> "Q9QXQ1-1","RefSeq","NP_038903.3","25457552","It is one of the enzymes responsible for controlling specifically the intracellular levels of cyclic adenosine 3', 5'-monophosphate in the immune and central nervous systems."
> "Q9QXQ1-1","RefSeq","NP_038903.3","22088971","For the first time, it was demonstrated that the deletion of the PDE7B gene or the pharmacological inhibition of PDE7A and -B had no effect on ovalbumin-induced airway inflammation and airway hyperreactivity."
12946,12947d17386
< "P20917-1","RefSeq","NP_001333013.1","28522736","We show that myelin-associated glycoprotein or CNS myelin, in general, inhibit rodent Schwann cell migration and induce their death via cleavage of the neurotrophin receptor p75."
< "P20917-1","RefSeq","NP_001333013.1","27922006","The combination of trans ganglioside binding and cis homodimerization explains how MAG maintains the myelin-axon spacing and provides a mechanism for MAG-mediated bi-directional signalling. Publication Status: Online-Only"
12953a17393,17400
> "Q920V1-1","RefSeq","NP_064410.1","16079416","Gb3 and Gb4 synthase are responsible for the expression of globo-series glycolipids"
> "O55070-1","RefSeq","NP_031896.3","30593563","These results support a distinct role of DNASE1L3 as a regulator of the physical form and availability of cell-free DNA and may have important implications for the mechanism whereby this enzyme prevents autoimmunity."
> "O55070-1","RefSeq","NP_031896.3","29191910","DNase1 and DNase1-like 3 are independently expressed and thus provide dual host protection against deleterious effects of intravascular neutrophil extracellular traps."
> "O55070-1","RefSeq","NP_031896.3","27293190","Study reports that DNASE1L3-deficient mice rapidly develop autoantibodies to DNA and chromatin, followed by an systemic lupus erythematosus-like disease. Circulating DNASE1L3 is produced by dendritic cells and macrophages, and its levels inversely correlate with anti-DNA antibody response."
> "O55070-1","RefSeq","NP_031896.3","24312463","DNase gamma, but not CAD, is the effector endonuclease for INDF in cells undergoing necrosis. Publication Status: Online-Only"
> "O55070-1","RefSeq","NP_031896.3","19154352","Serum contains two nucleases, DNase1 and DNase1l3, which may substitute or cooperate with each other during DNA degradation, providing effective clearance after exposure or release from dying cells."
> "O55070-1","RefSeq","NP_031896.3","17218958","These results suggest that DNasegamma provides an alternative mechanism for inducing nuclear changes when the working apoptotic cascade is unsuitable for caspase-activated DNase activation."
> "O55070-1","RefSeq","NP_031896.3","15796714","A comparison of the expression and transport of DNAse1 from rats and DNAse1L3 from mice is reported."
12959a17407,17411
> "Q8BHI7-1","RefSeq","NP_599016.2","24814977","These studies establish that Elovl5 activity regulates hepatic levels of FAs controlling PPARbeta activity, ATGL expression, and TG catabolism, but not FA oxidation."
> "Q8BHI7-1","RefSeq","NP_599016.2","24184513","Knockdown of Elovl5, Fads1, or Fads2 decreased the level of Mead acid."
> "Q8BHI7-1","RefSeq","NP_599016.2","20488798","Results establish a link between fatty acid elongation and hepatic glucose metabolism and suggest a role for regulators of Elovl5 activity in the treatment of diet-induced hyperglycemia."
> "Q8BHI7-1","RefSeq","NP_599016.2","18838740","Reduced ELOVL5 activity leads to hepatic steatosis, and endogenously synthesized PUFAs are key regulators of SREBP-1c activation and fatty acid synthesis in liver"
> "Q8BHI7-1","RefSeq","NP_599016.2","18376007","Elovl5-induced changes in hepatic fatty acid content affect multiple pathways regulating hepatic lipid and carbohydrate composition"
12967a17420,17421
> "Q64321-1","RefSeq","NP_033591.2","30638736","Thpok-dependent circuitry promotes both memory CD4+ T cell differentiation and functional fitness"
> "Q64321-1","RefSeq","NP_033591.2","30295892","Silencer element functionally equivalent between marsupial and placental mammals"
12978,12979d17431
< "P70170-1","RefSeq","NP_066378.1","28121062","Cardiac SUR2A levels were significantly increased while Kir6.2 levels were not affected. Hypoxia did not induce phosphorylation of extracellular signal-regulated kinases (ERK1/2) or protein kinase B (Akt), but triggered phosphorylation of AMP activated protein kinase (AMPK). AICAR, an activator of AMPK, increased the level of SUR2A in H9c2 cells. We conclude that oxygen increases SUR2A level by activating AMPK."
< "P70170-1","RefSeq","NP_066378.1","27086859","K(ATP) channels seem to play an essential role in murine myometrial motility via activation of SUR2B and Kir6.2"
12982a17435
> "Q60989-1","RefSeq","NP_033818.2","29899110","Differentiation of macrophages increased the expression of pro-inflammatory cytokines but reduced RipK1-dependent cell death and the RipK3-caspase-8 interaction. The expression of the anti-apoptotic mediators, X-linked inhibitor of apoptosis protein (XIAP) and caspase-like apoptosis regulatory protein (cFLIPL), also increased in differentiated macrophages, which inhibited caspase activation."
12986a17440,17443
> "Q80SU6-1","RefSeq","NP_543130.2","29398136","Nampt/NAD(+) system for Npt2 regulation and cellular shifts to tissues such as the liver play an important role in generating daily oscillation of plasma inorganic phosphate levels."
> "Q80SU6-1","RefSeq","NP_543130.2","24553430","We have generated a renal-specific and inducible knockout model of NaPi-IIc/Slc34a3. absence of NaPi-IIc does not disturb the homeostasis of Pi in mice. However, ablation of the cotransporter in weaning mice does not alter the homeostasis of Ca2+."
> "Q80SU6-1","RefSeq","NP_543130.2","19056871","Npt2c maintains normal Ca metabolism, in part by modulating the vitamin D/fibroblast growth factor 23 axis."
> "Q80SU6-1","RefSeq","NP_543130.2","15007650","NaPi-IIc mRNA and protein was up-regulated by the low-Pi diet in all nephron generations analysed"
12991a17449,17452
> "O88839-1","RefSeq","NP_033744.1","29939250","ADAM15 has a critical role in mediating vascular barrier dysfunction during inflammation. Its mechanisms of action involve CD44 shedding and endothelial glycocalyx injury."
> "O88839-1","RefSeq","NP_033744.1","25650586","Findings indicated that silencing ADAM15 had antiinflammatory effects in FLSs and efficiently inhibited the development of CIA."
> "O88839-1","RefSeq","NP_033744.1","25249606","The catalytic activity of ADAM15 is not crucial for its function in promoting pathological neovascularization in the mouse OIR model, most likely because of the very limited substrate repertoire of ADAM15. Publication Status: Online-Only"
> "O88839-1","RefSeq","NP_033744.1","23161886","ADAM15 upregulation contributes to inflammatory lung injury by promoting endothelial hyperpermeability and neutrophil transmigration."
12998a17460,17461
> "Q91X78-1","RefSeq","NP_663477.3","30135210","The erlin2 threonine to isoleucine 65 substitution inhibits erlin1/erlin2 complex-mediated inositol 1,4,5-trisphosphate receptor ubiquitination and phosphatidylinositol 3-phosphate binding."
> "Q91X78-1","RefSeq","NP_663477.3","22020079","2 MDa erlin1/2 complex is composed of an assemblage of lower-order hetero-oligomers, probably heterotrimers, linked together by assembly domain hydrophobic residues."
13005,13012d17467
< "Q810L3-1","RefSeq","NP_001276506.1","26566864","CHFR is important for the survival of male premeiotic germ cells, which is likely through maintaining genomic stability in spermatogonial stem cells."
< "Q810L3-1","RefSeq","NP_001276506.1","22337872","The interaction between CHFR and PARP-1 plays an important role in cell cycle regulation and cancer therapeutic strategies."
< "Q810L3-1","RefSeq","NP_001276506.1","22285184","CHFR interacts with BRG1, SNF5, and BAF60a of the SWI/SNF-like BAF complex and ubiquitinates them to target for degradation through a proteasome-mediated pathway; SRG3 stabilizes these components by blocking their interaction with CHFR."
< "Q810L3-1","RefSeq","NP_001276506.1","21706008","RNF8 and Chfr, function together to activate ATM and maintain genomic stability in vivo. Publication Status: Online-Only"
< "Q810L3-1","RefSeq","NP_001276506.1","21245198","Stil protein regulates centrosome integrity and mitosis through suppression of Chfr."
< "Q810L3-1","RefSeq","NP_001276506.1","19690386","Mice with deficiencies in both Chfr and Mlh1 (the gene that encodes the DNA mismatch-repair protein Mlh1) displayed dramatically higher incidence of spontaneous tumors relative to mice deficient for only one of these genes."
< "Q810L3-1","RefSeq","NP_001276506.1","15793587","Downregulation of Chfr contributes to tumorigenesis by controlling the expression levels of Aurora A."
< "Q810L3-1","RefSeq","NP_001276506.1","15467728","PML bodies control the distribution, dynamics and function of CHFR"
13017a17473,17478
> "P56931-1","RefSeq","NP_808401.1","28558060","Genomic structure, expression pattern, and functional characterization of transcription factor E2F-2 from black tiger Publication Status: Online-Only"
> "P56931-1","RefSeq","NP_808401.1","27795297","Findings implicate E2F-2 in regulating the expression of mitotic kinases that are adapted to perform specialized functions in nuclear condensation and enucleation of maturing erythroblasts. Publication Status: Online-Only"
> "P56931-1","RefSeq","NP_808401.1","26505089","Spinal cord injury-induced activation of E2F1-2 mediates cell cycle activation, contributing to gliopathy and neuronal/tissue loss associated with motor impairments and post-traumatic hyperesthesia."
> "Q91VI7-1","RefSeq","NP_660117.2","29408805","RNH1 binds to the 40S subunit of ribosomes and facilitates polysome formation on Gata1 mRNA to confer transcript-specific translation."
> "Q91VI7-1","RefSeq","NP_660117.2","24941155","X-ray crystallographic analysis of RNH1 from mouse, bovine and chicken binding to RNase reveals two residues that appear to contribute to the differential binding affinity."
> "Q91VI7-1","RefSeq","NP_660117.2","20307645","Mouse angiogenin inhibitor 1 interacts with hylA of Streptococcus suis."
13042c17503,17510
< "Q8R2U0-1","RefSeq","NP_001034177.1","20824097","Seh1l expression is associated with susceptibility to Staphylococcus aureus sepsis. Publication Status: Online-Only"
---
> "P70406-1","RefSeq","NP_035801.3","30885735","The results imply that UCP2 facilitates glutamine utilization as an energetic fuel source, thereby providing metabolic flexibility during glucose shortage."
> "P70406-1","RefSeq","NP_035801.3","31080837","Uncoupling protein 2 (UCP2) involves immune response, regulation of oxidative stress, and maintenance of mitochondrial membrane potential as well as energy production. UCP2 drives septic cardiac dysfunction and that the targeted induction of UCP2-mediated autophagy may have important therapeutic potential. Publication Status: Online-Only"
> "P70406-1","RefSeq","NP_035801.3","30664764","Study data indicate that UCP2 induction in melanoma cells blocks the immunosuppressive feature of the tumor microenvironment by shifting the cytokine milieu in an interferon regulatory factor 5-dependent manner, leading to engagement of the conventional type 1 dendritic cell- and CD8+ T cell-dependent anti-tumor immune cycle, and prolonged survival in mouse B16 melanoma model. Erratum:[Nat Immunol. 2019 Apr;20(4):515-516. PMID: 30862953]"
> "Q9DB50-1","RefSeq","NP_081163.2","27411398","AP-1/sigma1A-ArfGAP1-Rabex-5 complex formation leads to more endosomal Rabex-5 and enhanced, Rab5(GTP)-stimulated Vps34 PI3-kinase activity, which is essential for multivesicular body endosome formation. Publication Status: Online-Only"
> "Q9DB50-1","RefSeq","NP_081163.2","20203623","Synaptic vesicle reformation in cultured neurons from adaptor protein complex AP-1 sigma-1B-deficient mice is reduced upon stimulation, and large endosomal intermediates accumulate. Erratum:[EMBO J. 2010 Jun 2;29(11):1941. Boning, Daniel [corrected to Boening, Daniel]]"
> "Q9Z0P7-1","RefSeq","NP_056567.2","30554998","Establishes the dual role of SUFU inSonic Hedgehog medulloblastoma (MB) and provides mechanistic insights into transcriptional regulation underlying Gli2-mediated SHH MB tumorigenesis"
> "Q9Z0P7-1","RefSeq","NP_056567.2","29923621","Study found that miR-423 targets the 3'-untranslated region (UTR) of Sufu, and the expression of Sufu can be inhibited by the overexpression of miR-423, indicating that Sufu could be the target of miR-423."
> "Q9Z0P7-1","RefSeq","NP_056567.2","29515120","Beta-Arrestin2 increases the Itch-mediated ubiquitylation of SuFu. Publication Status: Online-Only"
13044a17513,17520
> "Q3UA16-1","RefSeq","NP_079841.1","21084868","Spc25 is required for chromosome alignment, spindle formation, and proper spindle checkpoint signaling during meiosis."
> "P35412-1","RefSeq","NP_032177.1","22879962","Studying metabolic and emotionality parameters in Gpr12 mutant mice did not reveal a major phenotypic impact of the gene mutation."
> "P35412-1","RefSeq","NP_032177.1","16887097","GPCR12 is considered important for the energy balance since GPCR12 KO mice develop obesity and have lower energy expenditure."
> "P35412-1","RefSeq","NP_032177.1","16229830","The cAMP levels required for maintaining meiotic arrest in mouse and rat oocytes are dependent on the expression of Gpr3 and/or Gpr12"
> "P13609-1","RefSeq","NP_035287.1","29588174","Serglycin produced in lipopolysaccharide-induced inflammation in normal mouse chondrocytes is able to modulate inflammation by interacting with CD44 receptor, suggesting a possible key role in the cartilage inflammation."
> "P13609-1","RefSeq","NP_035287.1","28843862","Findings indicate that PRG-1 deficiency led to over-excitability caused by an altered LPA/LPA2-R signaling inducing a behavioral phenotype typically observed in animal models for psychiatric disorders."
> "P13609-1","RefSeq","NP_035287.1","27267469","This study shows that the serglycin-deficient mice are more susceptible to Trichinella spiralis infection and display an unbalanced immune response Publication Status: Online-Only"
> "P13609-1","RefSeq","NP_035287.1","27223472","Data suggest that serglycin proteoglycans play a role in extravasation as well as colonization and growth of metastatic cells. Publication Status: Online-Only"
13061a17538,17545
> "Q9ES63-1","RefSeq","NP_067298.2","29734399","The mutants with abrogation of the two paternally expressed genes, Peg3 and Usp29, showed a significant decrease in growth rates for both males and females, while the mutants with biallelic expression of Peg3 and Usp29 resulted in an increased growth rate of female mice only Publication Status: Online-Only"
> "Q9ES63-1","RefSeq","NP_067298.2","27327533","The transcription of Usp29 may be involved in DNA methylation setting of Zfp264 promoter in a sex-specific manner. Publication Status: Online-Only"
> "Q8VC70-1","RefSeq","NP_062685.2","22198336","SRC-3 protein is a significant regulator of infection and inflammation, and SRC-3 protein play an essential role in the development of immunosuppression accompanied with SIRS(systemic inflammatory response syndrome)."
> "Q8K202-1","RefSeq","NP_073722.1","28042089","DNA sequencing demonstrated that in the absence of ectopic PAF53 expression, cells demonstrated unique means of surviving; including recombination or the utilization of alternative reading frames. We never observed a clone in which one PAF53 gene is expressed, unless there was also ectopic expression In the absence of ectopic gene expression, the gene products of both endogenous genes were expressed, irrespective of wheth"
> "Q8K202-1","RefSeq","NP_073722.1","22849406","Yeast A34.5/A49 and mammalian PAF49/PAF53 heterodimeric complexes interact through species-specific sequence elements that appear to assume similar structural motifs."
> "P97794-1","RefSeq","NP_032454.1","30315808","Kir6.1 channel protects brain from cerebral ischemia/reperfusion injury through inhibiting endoplasmic reticulum stress."
> "P97794-1","RefSeq","NP_032454.1","29666184","Kir6.1-containing KATP channels in the sinoatrial node have a role in excitability, heart rate control, and the electrophysiological adaptation of the sinoatrial node to hypoxia."
> "P97794-1","RefSeq","NP_032454.1","11984590","Gene disruption causes prinzmetal angina in knockout mice"
13062a17547,17550
> "Q9JIW9-1","RefSeq","NP_071722.1","29437579","Platelet Ral GTPases primarily control P-selectin surface expression, in turn regulating platelet-leukocyte interaction."
> "Q9JIW9-1","RefSeq","NP_071722.1","27269287","This study identifies a novel regulatory crosstalk between Ral and Arf6 that controls Ral function in cells."
> "Q9JIW9-1","RefSeq","NP_071722.1","23063435","Findings show either RALA or RALB is sufficient for tumor growth; either RALA or RALB is sufficient for cell proliferation; RALA and RALB act in a redundant fashion"
> "Q9JIW9-1","RefSeq","NP_071722.1","20679536","Endogenous RalB plays a negative role in the ingestion process of Fc gamma receptor-mediated macrophage phagocytosis."
13070a17559,17563
> "Q80TJ7-1","RefSeq","NP_796175.1","29317619","PHD zinc finger 8 protein (Phf8) knockout mice display normal brain development but impaired learning and memory, and compromised long-term potentiation (LTP) in the hippocampus. Publication Status: Online-Only"
> "Q80TJ7-1","RefSeq","NP_796175.1","28485378","These results clarify the functional role of Phf8 in mammalian development and behavior. Publication Status: Online-Only"
> "Q80TJ7-1","RefSeq","NP_796175.1","26866517","Knockdown of pmaip1 mimicked the phenotype of ph8(-/Y) by showing the decreased apoptosis during early differentiation of embryonic stem cells and promoted mesodermal and cardiac commitment."
> "Q80TJ7-1","RefSeq","NP_796175.1","25921086","PHF8 overexpression reversed cardiac dysfunction, hypertrophy and fibrosis upon pressure overload in PHF8 transgenic mice."
> "Q80TJ7-1","RefSeq","NP_796175.1","16199551","An important function of PHF8 is in midline formation and in the development of cognitive abilities, and may have a role in X linked mental retardation associated with cleft lip/palate"
13073a17567,17569
> "Q9ESD7-1","RefSeq","NP_067444.2","29771357","While halofuginone did not affect patch-repair-complex key proteins, it further enhanced Syt-7 levels and its spread across the cytosol in dysf-/- myofibers and muscle tissue, and increased its co-localization with lysosomes. Together, the data imply a novel role for halofuginone in membrane-resealing events with Syt-7 possibly taking part in these events."
> "Q9ESD7-1","RefSeq","NP_067444.2","11959863","Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains."
> "Q9ESD7-1","RefSeq","NP_067444.2","11891182","SJL/J mice show spontaneous myopathy and have a mutation in the dysferlin gene, a gene which is also mutated in human limb-girdle muscular dystrophy type 2B (LGMD2B)"
13086a17583,17584
> "Q5FWI3-1","RefSeq","NP_114386.3","28246172","These data suggest that TMEM2 is the long-sought-after hyaluronidase that cleaves extracellular HMW-HA into intermediate-size fragments before internalization and degradation in the lysosome."
> "Q5FWI3-1","RefSeq","NP_114386.3","21896629","Immature AVC expansion in wkm mutants is rescued by depleting Bmp4, indicating that Tmem2 restricts bmp4 expression to delimit the AVC primordium during cardiac development"
13093a17592,17599
> "Q8VBT3-1","RefSeq","NP_783440.1","23817038","OSCAR expression in monocytic cells is regulated by proatherogenic stimuli further pointing towards a role in vascular inflammation or plaque vulnerability during atherosclerosis"
> "Q8VBT3-1","RefSeq","NP_783440.1","21841309","Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice."
> "Q8VBT3-1","RefSeq","NP_783440.1","18762192","Results indicate that USFs 1 and 2 serve as modulators in the induction of OSCAR and RANKL-mediated osteoclastogenesis."
> "Q8VBT3-1","RefSeq","NP_783440.1","17442941","The overexpression of PIAS3 attenuates osteoclast formation and down-regulates the expression of NFATc1 and osteoclast-associated receptor (OSCAR), which are important modulators in osteoclastogenesis."
> "Q8VBT3-1","RefSeq","NP_783440.1","16109714","Analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1, involving NFATc1-mediated OSCAR expression and its subsequent activation of NFATc1, necessary for efficient differentiation of osteoclasts"
> "Q8VBT3-1","RefSeq","NP_783440.1","16046394","OSCAR but not TREM-2 is involved in the positive feedback loop of the immunoreceptor-NFATc1 pathway during osteoclastogenesis"
> "Q8VBT3-1","RefSeq","NP_783440.1","15184345","The FcRgamma-mediated signal transduction by OSCAR is involved in osteoclast differentiation"
> "Q8VBT3-1","RefSeq","NP_783440.1","12695521","PU.1 and MITF transcription factors synergistically activate OSCAR gene expression, which is further enhanced by the TRANCE-induced MKK6/p38 signaling cascade."
13096a17603
> "Q6X632-1","RefSeq","NP_780699.2","23979485","Although CCL5 is implicated in the pathogenesis of diabetes through activation of CCRs, it has beneficial effects on beta cells through GPR75 activation."
13111a17619,17621
> "O88627-1","RefSeq","NP_766568.1","29595077","It is a purine nucleoside preferring transporter playing a central role in the gastrointestinal absorption of purines in the enterocytes."
> "O88627-1","RefSeq","NP_766568.1","20421393","Data concluded that CNT2 contributes considerably to nucleoside uptake in rat hepatocytes but not in mouse hepatocytes."
> "O88627-1","RefSeq","NP_766568.1","17013559","TGF-beta1 transcriptionally activates the CNT2-encoding gene in a JNK-dependent manner."
13114a17625,17628
> "O70458-1","RefSeq","NP_035149.2","30431059","The results of the present study provide evidence that the overexpression of miR183 promotes the apoptosis of substantia nigra neurons by inhibiting the expression of OSMR."
> "O70458-1","RefSeq","NP_035149.2","30134804","The current study suggested that the OSMR gene is highly expressed in human chronic autoimmune urticaria (CAU) skin tissues, and cause the up-regulation of the JAK/STAT3 signaling pathway-related genes. OSMR gene silencing in mice inhibits the activation of the JAK/STAT3 signaling pathway, thereby suppressing the development of CAU. Publication Status: Online-Only"
> "O70458-1","RefSeq","NP_035149.2","29142070","The results suggest that BRG1 and STAT3 coordinately regulate gene clustering and up-regulate Gfap and Osmr transcription in astrocytes."
> "O70458-1","RefSeq","NP_035149.2","12814362","Expression of oncostatin M receptor beta in a specific subset of nociceptive sensory neurons."
13115a17630,17632
> "Q9D2F5-1","RefSeq","NP_084465.1","23028632","MAPO2 gene product might positively contribute to the induction of apoptosis triggered by O-methylguanine"
> "Q3UPF5-1","RefSeq","NP_083140.1","23776219","S-farnesylation is crucial for targeting the long-isoform of ZAP to endolysosomes and enhancing the antiviral activity of this immune effector."
> "Q3UPF5-1","RefSeq","NP_083140.1","22951821","ZAP inhibits M2 expression and regulates the maintenance of MHV-68 latency"
13118a17636,17637
> "Q91XA2-1","RefSeq","NP_081583.3","30396165","GOLM1 expression and glutamine metabolism were suppressed by osteogenic differentiation-inducing media. GOLM1 blockage or inhibition of glutamine metabolism promoted the osteogenic differentiation of BMSCs induced by osteogenic differentiation-inducing media."
> "Q91XA2-1","RefSeq","NP_081583.3","19596473","In Atp7b(-/-) mice, GP73 mRNA was significantly elevated at 20-46 weeks of age, coincident with extensive hepatic inflammation and fibrosis."
13124a17644,17646
> "Q9JIZ9-1","RefSeq","NP_076053.1","26677203","Results suggest that Scr3 functions as a negative regulator of adipogenesis in 3T3-L1 cells at a specific differentiation stage and that decrease in the intracellular amount of Scr3 protein caused by reduction in Scr3 mRNA expression Publication Status: Online-Only"
> "Q9JIZ9-1","RefSeq","NP_076053.1","17355638","Identified previously unrecognized lipid metabolites that suggest a novel molecular link between obesity, inflammation and the downstream consequences associated with PLSCR3-deficiency"
> "Q9JIZ9-1","RefSeq","NP_076053.1","15328404","Expression of PLSCR3 may be required for normal adipocyte and/or macrophage maturation or function"
13148a17671,17674
> "Q5DTL9-1","RefSeq","NP_001229312.1","24905082","Finding show that somatodendritic expression of Slc4a10 undergoes neuron type- and input pathway-dependent regulation in adult brains"
> "Q5DTL9-1","RefSeq","NP_001229312.1","15567717","NCBE is expressed in the peripheral nervous system and in non-neuronal tissues as the choroid plexus, the dura, and some epithelia including the acid secreting epithelium of the stomach and the duodenal epithelium."
> "Q5DTL9-1","RefSeq","NP_001229312.1","14592810","SLC4A10 gene product and NBCn1 both function as basolateral HCO3- entry pathways and that the SLC4A10 gene product may be responsible for the stilbene-sensitive Na+-HCO3- uptake that is essential for cerebrospinal fluid production."
> "Q08775-1","RefSeq","NP_033950.2","31347330","The specific binding of ANCR with EZH2 suppressed RUNX2, thereby inhibiting osteogenesis."
13152a17679,17683
> "Q8R4T9-1","RefSeq","NP_109608.1","27914708","Functional deficiency of all UTs caused a urea-selective urine-concentrating defect with little physiological abnormality in extrarenal organs."
> "Q8R4T9-1","RefSeq","NP_109608.1","27161213","Results suggest that GSK3 may in part modulate the hypertonic-induced intracellular UT-A1 redistribution and its accumulation on the plasma membrane, which may constitute another mechanism by which GSK3 modulates urine concentration"
> "Q8R4T9-1","RefSeq","NP_109608.1","25298343","Studies indicate that urea transporter Slc14a2 (UT-A1/3) knockout mouse models showed the essential role of urea for producing maximally concentrated urine. Review article"
> "Q8R4T9-1","RefSeq","NP_109608.1","12952854","Potassium depletion is associated with reduced expression of UT-A1, UT-A3, and UT-B but increased expression of UT-A2."
> "Q8R4T9-1","RefSeq","NP_109608.1","11880324","Levels of UTA mRNA were increased in thirsted mice compared with control animals"
13158a17690,17694
> "Q2TA50-1","RefSeq","NP_084269.1","27723895","Cell passaging severely reduced the expression of genes encoding markers typical of UM, including those of the prognostic gene signature. Marked differences between gene expression profiles of primary tumors and cell lines could be linked to the infiltrating immune and stromal cells in situ."
> "Q2TA50-1","RefSeq","NP_084269.1","21943097","MART-1 is a pigmentation gene that is required for melanosome biogenesis and/or maintenance."
> "Q2TA50-1","RefSeq","NP_084269.1","21309074","Results suggest that the MART-1::Cre line may serve as a novel and useful tool for functional studies in melanocytes and retinal pigment epithelium."
> "Q2TA50-1","RefSeq","NP_084269.1","19717472","OA1 interacts with MART-1 at early stages of melanogenesis to control melanosome identity and composition."
> "Q2TA50-1","RefSeq","NP_084269.1","17699571","MLANA and p53 have roles in virus replication"
13168,13170c17704,17705
< "Q60929-1","RefSeq","NP_001028885.1","29054930","Canonical pathway analysis of genes preferentially dysregulated in the atria and ventricles revealed distinct MEF2A-dependent cellular processes in each cardiac chamber. In the atria, MEF2A regulated genes involved in fibrosis and adhesion, whereas in the ventricles, it controlled inflammation and endocytosis."
< "Q60929-1","RefSeq","NP_001028885.1","28965945","Deficiency of AKT2 in myocardium results in diminished MEF2A abundance, which induced decreased size of cardiomyocytes. We additionally confirmed that EndoG, which is also regulated by AKT2, is a suppressor of MEF2A in myocardium."
< "Q60929-1","RefSeq","NP_001028885.1","28901289","Both synapse silencing and elimination required de novo transcription, but only silencing required the activity-dependent transcription factors MEF2A/D. Publication Status: Online-Only"
---
> "A4QPC6-1","RefSeq","NP_787952.2","26809444","Btn2a2(-/-) mice exhibited enhanced effector CD4(+) and CD8(+) T cell responses, impaired CD4(+) regulatory T cell induction, potentiated antitumor responses, and exacerbated experimental autoimmune encephalomyelitis."
> "A4QPC6-1","RefSeq","NP_787952.2","20208008","These data are consistent with a coinhibitory role for mouse Butyrophilins"
13178a17714,17717
> "P00920-1","RefSeq","NP_033931.4","28254758","It was concluded that both MCT1 and CAII are involved in the homeostatic control of pH in skeletal muscle, both at rest and at the onset of exercise. The improved muscle function and resistance to fatigue in MCT1(+/-) mice remain unexplained."
> "Q99NF1-1","RefSeq","NP_573480.1","30006135","Provided novel experimental evidence that BCO1 and BCO2 could play a significant role in maintaining normal hepatic lipid and cholesterol homeostasis, potentially through the regulation of the FXR/miR-34a/SIRT1 pathway"
> "Q99NF1-1","RefSeq","NP_573480.1","28482236","BCO2 regulates hypothalamic mitochondrial function, nutrient metabolism, and local oxidative stress and inflammation."
> "Q99NF1-1","RefSeq","NP_573480.1","21106934","We found that the third family member, beta,beta-carotene-9',10'-oxygenase (BCDO2), is a mitochondrial carotenoid-oxygenase with broad substrate specificity"
13188a17728,17729
> "Q99PP9-1","RefSeq","NP_444399.2","31342168","TRIM16 expression in keratinocytes is involved in cross talk between keratinocytes and melanocytes, and has a role in melanoma tumorigenesis."
> "Q99PP9-1","RefSeq","NP_444399.2","23341783","We demonstrate that genetic variation in Trim16 leads to its strain-dependent expression, which alters susceptibility to bleomycin-induced pulmonary fibrosis in mice. Erratum:[PLoS Genet. 2013 Oct;9(10). doi:10.1371/annotation/f184e509-5c53-48da-b94a-b7517f591b3e. Depault, Francois [added]]"
13195c17736,17740
< "Q91YM4-1","RefSeq","NP_001123929.1","18255060","Tight regulation of WAP gene expression parallels variations in the chromatin structure and DNA methylation profile throughout the Ramp3-WAP-Tbrg4 locus."
---
> "P23708-1","RefSeq","NP_035043.1","31296853","Through genome-wide studies in mouse embryonic stem cells study finds that NF-Y is essential for the maintenance of the nucleosome-depleted region at gene promoters. Depletion of the NF-YA protein leads to the accumulation of ectopic nucleosomes over the transcription start site, reducing promoter accessibility. Publication Status: Online-Only"
> "P23708-1","RefSeq","NP_035043.1","29530977","The results reveal a previously unrecognized physiological function of NFYA in controlling glucose metabolism by up-regulating the gluconeogenic genes Pck1 and G6pc."
> "P23708-1","RefSeq","NP_035043.1","28281280","Data show that nuclear factor Y (NF-Y) binds to the inverted CCAAT element (ICE) in the Fatty acid synthase (Fasn) promoter specifically in refeeding states."
> "P23708-1","RefSeq","NP_035043.1","27837431","Findings may point to a possible role of NF-YA in stress conditions that occur in chronic obesity, ER stress might be involved in the pathogenesis of obesity through NF-YA depletion."
> "O55222-1","RefSeq","NP_034692.2","29787808","Lipoxin A4 and its analog suppress hepatocarcinoma cell epithelial-mesenchymal transition, migration and metastasis via regulating integrin-linked kinase axis."
13198a17744,17745
> "Q61036-1","RefSeq","NP_032804.2","29860311","Furthermore, pharmacological inhibition of PAKs decreases ATXN1 levels in a mouse model of SCA1. To explore the potential of using PAK inhibitors in combination therapy, we combined the pharmacological inhibition of PAK with MSK1, a previously identified modulator of ATXN1, and examined their effects on ATXN1 levels. We found that inhibition of both pathways results in an additive decrease in ATXN1 levels."
> "Q61036-1","RefSeq","NP_032804.2","27940202","Pak3 knockout (KO) mice had defects of oligodendrocyte differentiation in developing corpus callosum and to a lesser extent in anterior commissure, which were compensated at the adult stage. In vitro experiments in oligodendrocyte precursor (OPC) cultures, derived from Pak3 KO and wild type brains, support a developmental and cell-autonomous role for PAK3 in regulating OPC differentiation into mature oligodendrocytes."
13200a17748,17750
> "Q91YD6-1","RefSeq","NP_035830.2","15576363","H. pylori induction of villin in the stomach correlates with activation and cooperative binding of Elk-1 and the SRF to the proximal promoter of villin"
> "Q91ZV3-1","RefSeq","NP_082799.2","26921437","ESDN regulates insulin signaling and subsequently a wide array of insulin effects in cultured cells and in vivo through modulation of IR interaction with APS and Grb10."
> "Q91ZV3-1","RefSeq","NP_082799.2","24177422","Deletion of Esdn in the mouse interfered with adult and developmental angiogenesis."
13202a17753,17756
> "Q8VDU3-1","RefSeq","NP_776147.1","27697524","ApoL9 is a phosphatidylethanolamine -binding protein that may have important roles in several cellular processes that involve this phospholipid."
> "Q00690-1","RefSeq","NP_035475.1","30988423","E-selectin binding activity mediated by the alpha1-3 fucosyltransferases Fut3/Fut6 and Glg1 are instrumental to the formation of bone metastasis. These findings provide unique insights into the functional role of E-selectin as a component of the vascular niche critical for metastatic colonization in bone."
> "Q00690-1","RefSeq","NP_035475.1","30633612","Sele is a potential miR-21 target"
> "Q00690-1","RefSeq","NP_035475.1","27885671","Before the arrival of tumor cells, the lung-recruited monocytic myeloid-derived suppressor cells produced IL-1beta, thereby increasing E-selectin expression and promoting tumor cell arrest on endothelial cells."
13206,13207c17760,17764
< "Q9R0Y5-1","RefSeq","NP_001185719.1","24740601","In addition to AK1 and AK2, which we previously demonstrated are present in outer dense fibers and mitochondrial sheath of the mouse sperm tail, we show that another AK, AK8, is present in a third flagellar compartment, the axoneme."
< "Q9R0Y5-1","RefSeq","NP_001185719.1","23447692","CaMKIalpha regulates AMP kinase-dependent, TORC-1-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation."
---
> "Q923J1-1","RefSeq","NP_067425.2","30305398","Internal Mg(2+)-, polyamine-, and pH-mediated inhibition of TRPM7 channels is not direct but, rather, reflects electrostatic screening and resultant disruption of PI(4,5)P2-channel interactions."
> "Q923J1-1","RefSeq","NP_067425.2","30322909","The identification of TRPM7 and CaV3.2 as key mediators of Ca(2+) influx following fertilization."
> "Q923J1-1","RefSeq","NP_067425.2","30076216","Findings suggest that TRPM7 channel activities play a key role in HG-associated ERS and cytotoxicity through an apoptosis-inducing signaling cascade involving HG, iNOS, TRPM7, ERS proteins, and caspases"
> "Q923J1-1","RefSeq","NP_067425.2","30108148","Results provide a structural framework for understanding the TRPM1/3/6/7 subfamily and extend the knowledge base upon which to study the diversity and evolution of TRP channels."
> "Q923J1-1","RefSeq","NP_067425.2","12508053","The Trpm7 ion channel possesses the unique ability to efficiently conduct many essential trace metal ions such as Zn2+, Fe2+, Cu2+, Mn2+, and Co2+ into cells, along with several toxic metal ions such as Cd2+, Ba2+, and Sr2+ as well."
13215a17773
> "Q9D3X8-1","RefSeq","NP_081993.1","17971504","Dydc2 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
13218a17777,17778
> "O88286-1","RefSeq","NP_997603.3","27410475","Chromatin immunoprecipitation-DNA sequence analysis was performed in adult cerebellum and Wiz peaks were found at promoters and transcription factor CTCF binding sites. Publication Status: Online-Only"
> "O88286-1","RefSeq","NP_997603.3","16702210","Wiz plays a major role in G9a/GLP heterodimer formation in cultured stem cells."
13248a17809,17815
> "Q99LG0-1","RefSeq","NP_077220.2","27586445","USP16 and TTC3 were dysregulated in all affected human cells and two mouse models of Down syndrome. Publication Status: Online-Only"
> "Q99LG0-1","RefSeq","NP_077220.2","26699484","These studies identified Usp16 as one of the histone H2A deubiquitinases, which coordinates with the H2A ubiquitin ligase PRC1 to regulate hematopoiesis, and revealed cell cycle regulation by Usp16 as key for HSC differentiation."
> "Q99LG0-1","RefSeq","NP_077220.2","24784029","Study identifies Usp16 and H2A deubiquitination as critical regulators of ESC gene expression and differentiation Publication Status: Online-Only"
> "Q99LG0-1","RefSeq","NP_077220.2","24025767","Results suggest that USP16 has an important role in antagonizing the self-renewal and/or senescence pathways in Down's syndrome and could serve as an attractive target to ameliorate some of the associated pathologies"
> "Q6P9K9-1","RefSeq","NP_766132.2","29681532","Mice of the 129 strain carry a unique missense variant in neurexin 3 and exhibit a profound and selective enhancement in observational fear."
> "Q6P9K9-1","RefSeq","NP_766132.2","9856994","N-terminal sequencing of rat neurexin III alpha provides evidence for signal peptide"
> "Q6P9K9-1","RefSeq","NP_766132.2","8163501","N-terminal sequencing of cow neurexin III beta provides evidence for signal peptide"
13253,13255d17819
< "Q8K2C7-1","RefSeq","NP_001164497.1","26721884","Data suggest renal cell lines exhibit an OS9-mediated ERAD (endoplasmic reticulum-associated degradation) pathway that degrades Nkcc2/Slc12a1 (solute carrier family 12 member 1) prior to glycosylation/processing."
< "Q8K2C7-1","RefSeq","NP_001164497.1","21523322","The depletion of OS-9 in 3T3-L1 adipocytes impaired cell function in terms of triacylglycerol storage, and slightly influenced cell differentiation."
< "Q8K2C7-1","RefSeq","NP_001164497.1","17932042","OS-9 regulates the secretory transport of TRPV4 and appears to protect TRPV4 subunits from the precocious ubiquitination and ER-associated degradation."
13256a17821,17833
> "Q9JHF9-1","RefSeq","NP_058619.1","30299441","These results show that isofraxidin binds to and inhibits MD-2, thus preventing TLR4/MD-2 complex formation without altering TLR2 signalling.  We demonstrated that isofraxidin promoted cell proliferation and inhibited the lipopolysaccharide induced inflammatory response through suppressing the activation of the TLR4/MD-2 axis and NF-kappaB signalling in human osteoarthritis chondrocytes."
> "Q9JHF9-1","RefSeq","NP_058619.1","30424767","Studied anti-inflammatory effects of ethyl acetate extracts of E. sagittatum (Ying-Yang-Huo) and found it to inhibit toll-like receptor 4(TLR4)/ lymphocyte antigen 96(MD-2) thru the NF-kappaB signal pathway. Publication Status: Online-Only"
> "Q9JHF9-1","RefSeq","NP_058619.1","29077272","These results provide further evidence for the critical role of MD2 in the development of non-alcoholic steatohepatitis."
> "Q9JHF9-1","RefSeq","NP_058619.1","29368691","TLR4/MD2 activation leads only to formation of TLR4/MD2 heterotetramers, but not oligomers, suggesting a stoichiometric mismatch between activated receptors and MyDDosomes. Publication Status: Online-Only"
> "Q9JHF9-1","RefSeq","NP_058619.1","29111459","This study provides evidence that MD2 plays a key role in the pathogenesis of retinal I/R damage."
> "Q9JHF9-1","RefSeq","NP_058619.1","11884465","MD-2 in complex with toll-like receptor 4 mediates signal transduction induced by the amino acid-containing bacterial lipid, flavolipin. Erratum:[J Immunol 2002 May 15;168(10):5376]"
> "Q3UK78-1","RefSeq","NP_083784.1","29765032","Although PCGF5 is not required for embryonic stem cell (ESC) self-renewal, its loss blocks ESC neural differentiation by activating the SMAD2/TGF-beta signaling pathway. Publication Status: Online-Only"
> "Q3UK78-1","RefSeq","NP_083784.1","29054931","The knockout of Pcgf3, Pcgf5, or both resulted in a 39, 29, and 52% decrease, respectively, in global levels of H2AK119ub1 as compared with wild-type cells, as evidenced by Western blotting. In contrast, no similar change was observed for H3K27me3."
> "Q3UK78-1","RefSeq","NP_083784.1","29220657","HnRNPK recruits PCGF3/5-PRC1 to the Xist RNA B-repeat to establish polycomb-mediated chromosomal silencing."
> "Q3UK78-1","RefSeq","NP_083784.1","28596365","Authors conclude that RYBP/YAF2 binding to H2AK119u1 likely underpins the transient interaction of noncanonical PRC1 complexes with Xist RNA domains but does not account for stable interaction of PCGF3/5-PRC1 complexes."
> "Q3UK78-1","RefSeq","NP_083784.1","27136092","Findings demonstrate that Pcgf5-containing PRC1 functions as a histone modifier in vivo, but its role in HSPCs is limited and can be compensated by other PRC1-related complexes in HSPCs. Publication Status: Online-Only"
> "Q62507-1","RefSeq","NP_031754.1","25049087","Accumulation of acellular deposits in the incudomalleal and incudostapedial joints in Coch (G88E/G88E) mice similar to those found in human DFNA9-affected temporal bones"
> "Q62507-1","RefSeq","NP_031754.1","23684986","Study reports that cochlin is expressed by follicular dendritic cells (FDCs) and selectively localized in the fine extracellular network of conduits in the spleen and lymph nodes; by producing cochlin, FDCs contribute to the innate immune response in defense against bacteria"
13262a17840,17841
> "O88509-1","RefSeq","NP_034198.3","30468428","These genome-wide data combined with ultra-deep locus-specific bisulfite sequencing suggest a distributive activity of ectopically expressed Dnmt3b that leads to discordant CpG island hypermethylation and provides new insights for interpreting the cancer methylome. Publication Status: Online-Only"
> "O88509-1","RefSeq","NP_034198.3","21666347","Dnmt3bDelta6 could induce a hypomethylation status especially in in vitro manipulated embryos."
13267a17847,17849
> "Q5RKR3-1","RefSeq","NP_796167.2","29739947","These data suggest a role for Linx in the regulation of complex forebrain connectivity, and future identification of its extracellular ligand(s) will help clarify this function. Publication Status: Online-Only"
> "Q5RKR3-1","RefSeq","NP_796167.2","26492970","We identify a novel role for the LRR receptor Islr2 in ensuring proper axon navigation at the optic chiasm of both zebrafish and mouse. Publication Status: Online-Only"
> "Q9ER62-1","RefSeq","NP_076169.2","29973541","Transmembrane TNF, TNFR2 and TNFR1 (indirectly) are critical for preventing inflammation during BCG-induced pleurisy in mice. Publication Status: Online-Only"
13269a17852,17857
> "Q5SS00-1","RefSeq","NP_082949.1","24589776","A maternal germline differentially methylated region (DMR) at the mouse Gpr1/Zdbf2 (DBF-type zinc finger-containing protein 2) locus, which controls the paternal-specific expression of long isoforms of Zdbf2 (Liz) in the early embryo"
> "Q5SS00-1","RefSeq","NP_082949.1","22449967","Results identified a novel, paternally expressed, long intergenic non-coding Zdbf2 variant (Zdbf2linc) transcribed from maternally methylated Gpr1 during early embryogenesis in the mouse."
> "Q5SS00-1","RefSeq","NP_082949.1","20385583","Identification of differentially methylated regions within the Gpr1-Zdbf2 imprinted domain."
> "Q5SS00-1","RefSeq","NP_082949.1","19200453","Zdbf2 was paternally expressed in various embryonic and adult tissues, except for the placenta and adult testis, which showed biallelic expression of the gene."
> "Q9QWH1-1","RefSeq","NP_061244.1","24091011","Polymerization of the Phc2 SAM domain is required for PRC1 clustering, chromatin condensation and gene silencing."
> "Q9QWH1-1","RefSeq","NP_061244.1","23605804","Phc2 may act as a negative regulator that inhibits the activity of Th cells."
13279,13282d17866
< "Q9JLB0-1","RefSeq","NP_001158205.1","30357511","The results indicate that the MPP6-Lin7 complex regulates myelin formation."
< "Q9JLB0-1","RefSeq","NP_001158205.1","26496923","This paper herein showed the immunolocalization and interaction proteins of MPP6 in the mouse small intestine, and also that 4.1B in epithelial cells was not essential for the sorting of MPP6."
< "Q9JLB0-1","RefSeq","NP_001158205.1","23306908","The findings indicate that the Src-MPP6-4.1G protein complex in Schmidt-Lanterman incisures(SLIs) has a role in signal transduction in the peripheral nervous system(PNS)."
< "Q9JLB0-1","RefSeq","NP_001158205.1","22025680","In the mouse sciatic nerve, protein 4.1G colocalized at Schmidt-Lanterman incisures (SLI) and the paranodes with a member of the membrane-associated guanylate kinase (MAGUK) family, membrane protein palmitoylated 6."
13305a17890,17897
> "O88507-1","RefSeq","NP_057882.2","28529450","Study proposes a novel insight that miR-696 down-regulates C2C12 cell myogenesis by inhibiting CNTFRalpha expression. Publication Status: Online-Only"
> "O88507-1","RefSeq","NP_057882.2","27600775","The data, along with previous work indicating no effect of muscle specific ciliary neurotrophic factor alpha (CNTFRalpha) depletion on motor innervation, suggest that motor neuron and muscle CNTFRalpha function in concert to maintain motor neuron axons."
> "O88507-1","RefSeq","NP_057882.2","26718832","CNTFR expression was downregulated by androgen in the inguinoscrotal fat pad suggesting that the genitofemoral nerve may be masculinised to control gubernacular migration in the inguinoscrotal phase of testicular descent by a negative regulating mechanism in mouse embryos ."
> "Q8BX22-1","RefSeq","NP_958798.2","22385656","Plzf antagonizes Sall4 function by displacing Sall4 from cognate chromatin to induce Sall1 expression"
> "Q8BX22-1","RefSeq","NP_958798.2","17060609","Sall4 as an essential transcription factor required for the early development of inner cell mass-derived cell lineages"
> "Q8BX22-1","RefSeq","NP_958798.2","16790473","Sall4 and Sall1 form heterodimers, and a truncated Sall1 caused mislocalization of Sall4 in the heterochromatin; thus, some symptoms of Townes-Brocks syndrome caused by SALL1 truncations could result from SALL4 inhibition."
> "Q8BX22-1","RefSeq","NP_958798.2","16380715","A positive and negative feed-forward circuit between Tbx5 and Sall4 ensures precise patterning of embryonic limb and heart and provides a unifying mechanism for heart/hand syndromes."
> "Q8BX22-1","RefSeq","NP_958798.2","12826753","Cloning and expression analysis; prominent expression in the developing midbrain, branchial arches and the limbs suggests an important function of SALL4 during development of these structures"
13314a17907,17911
> "P19467-1","RefSeq","NP_034869.1","27399336","These data indicate that combining chemotherapy and MUC13 antagonism could improve the treatment of metastatic cancers"
> "P19467-1","RefSeq","NP_034869.1","24866791","Muc13 was upregulated in the fundus of the stomach already 1 day after infection with Helicobacter heilmannii."
> "P19467-1","RefSeq","NP_034869.1","23149663","These studies demonstrate that MUC1 and MUC13 are important components of gastrointestinal homeostasis and that disruption or inappropriate expression of these mucins could predispose to infectious and inflammatory disease and inflammation-induced cancer."
> "P19467-1","RefSeq","NP_034869.1","21636645","Protective role in the colonic epithelium by inhibiting toxin-induced apoptosis"
> "P19467-1","RefSeq","NP_034869.1","11922618","Hypothesize that NJ-1(+)megakaryocytes (MKs) are immature MKs and the NJ-1 molecule is involved in MK adhesion to endothelial cells [NJ-1]"
13319a17917,17921
> "Q61985-1","RefSeq","NP_032712.2","30559296","Nrf1, RUVBL1, and TIP60 proteins were co-recruited to the promoter regions of proteasome genes after proteasome inhibitor treatments."
> "Q61985-1","RefSeq","NP_032712.2","30287392","The nascent Nrf1alpha (NFE2L1)/TCF11 polypeptide (non-glycosylated) is transiently translocated into the endoplasmic reticulum (ER)."
> "Q61985-1","RefSeq","NP_032712.2","30268580","Putative ubiquitination of Nrf1 (Nf2el1) is not a prerequisite necessary for involvement of p97 in the client processing."
> "Q61985-1","RefSeq","NP_032712.2","30135079","Findings reveal novel functions of the NGLY1-NRF1 (Nfe2l1) pathway in mitochondrial homeostasis and inflammation and uncover an unexpected therapeutic strategy using pharmacological activators of NRF2 for treating mitochondrial and immune dysregulation"
> "Q61985-1","RefSeq","NP_032712.2","29935181","Mechanistic studies revealed that Nfe2l1 deficiency may disturb the expression of lipolytic genes in adipocytes, leading to adipocyte hypertrophy followed by inflammation, pyroptosis, and insulin resistance."
13329a17932
> "Q9CQG3-1","RefSeq","NP_671708.1","15950311","Data support the notion that MIZIP might interact with melanin-concentrating hormone receptor 1 (MCHR1) in a cell type specific manner in vivo, suggesting a role in the regulation of MCH signalling in distinct regions of the mammalian brain"
13341a17945
> "P97355-1","RefSeq","NP_033240.3","19001365","Alpha-difluoromethylornithine treatment of control mice or Gy-CAG/SpmS had no effect on balance"
13349a17954,17958
> "Q8BQU6-1","RefSeq","NP_780661.2","30325069","This study found the much more severe disruption of the blood-spinal cord barrier in the Cx47KO, than in EAE mice."
> "Q8BQU6-1","RefSeq","NP_780661.2","28732089","Main findings are that i) Cx47 is involved in the reversal of acute increases in serum triglycerides, ii) serum lipid levels of mice on chow but not high-cholesterol diet are affected by Cx47 and iii) Cx47-deficiency tends to increase plaque size but decreases macrophage content of diet-induced atherosclerotic plaques. Results show that Cx47-deficient mice do not display an overt lymphatic phenotype. Publication Status: Online-Only"
> "Q8BQU6-1","RefSeq","NP_780661.2","26953188","Data show that segregation of Foxc2 and NFATc1 transcription factor is closely associated with the highly polarized expression of connexins Cx37, Cx43, and Cx47."
> "Q8BQU6-1","RefSeq","NP_780661.2","12843301","Mice lacking either Cx47 or Cx32 are viable but mice lacking both connexins die by postnatal week 6 from CNS myelin sheath abnormalities, vacuolation, enlarged periaxonal collars, oligodendrocyte cell death, and axonal loss"
> "Q8BQU6-1","RefSeq","NP_780661.2","12805295","Cx47-deficient mice revealed a vacuolation of nerve fibers at the site of the optic nerve where axons are first contacted by oligodendrocytes and myelination starts; Cx32/Cx47-double-deficient mice developed action tremor and died ca 51 d after birth"
13362,13365d17970
< "Q8BMT4-1","RefSeq","NP_001334110.1","28459434","NRROS-deficient (Nrros(-/-)) mice show defects in motor functions and die before 6 months of age. Nrros(-/-) mice display astrogliosis and lack normal CD11b(hi)CD45(lo) microglia, but they show no detectable demyelination or neuronal loss. perivascular macrophage-like myeloid cells populate the Nrros(-/-) CNS. Cx3cr1-driven deletion of Nrros shows its crucial role in microglial establishment during early embryonic stages."
< "Q8BMT4-1","RefSeq","NP_001334110.1","26442864","This study presents NRROS as a novel negative regulator of RANKL-induced osteoclastogenesis."
< "Q8BMT4-1","RefSeq","NP_001334110.1","24550525","Results suggest that LRRC33 and TLRs may form a negative-feedback loop, which is important for the maintenance of immune homeostasis."
< "Q8BMT4-1","RefSeq","NP_001334110.1","24739962","NRROS provides a hitherto undefined mechanism for regulating ROS production--one that enables phagocytes to produce higher amounts of ROS, if required to control invading pathogens, while minimizing unwanted collateral tissue damage"
13372a17978,17979
> "Q3UJK4-1","RefSeq","NP_062527.2","25061210","These results not only define GTPBP2 as a ribosome rescue factor but also unmask the disease potential of mutations in nuclear-encoded tRNA genes."
> "Q9D0A0-1","RefSeq","NP_083861.1","29680877","The role of ABF1/3/4 in det1 germination phenotypes"
13381,13387c17988,17992
< "O54804-1","RefSeq","NP_001258425.1","26125130","Hepatic phosphatidylcholine is regulated by the circadian clock through a Bmal1-Rev-erbalpha-Chkalpha axis"
< "O54804-1","RefSeq","NP_001258425.1","20525991","Enforced expression of either CK(alpha) or CCTalpha increased the rate of synthesis and the amount of PtdCho, and these cells initiated neuronal differentiation."
< "O54804-1","RefSeq","NP_001258425.1","20026284","Lack of muscle degeneration in forelimbs of Chkb(-/-) mice is due to abundant choline kinase alpha and the stable homeostasis of phosphatidylcholine."
< "O54804-1","RefSeq","NP_001258425.1","18029352","Chka is an essential gene for early embryonic development, but adult mice do not require full expression of the gene for normal levels of phosphatidylcholine."
< "O54804-1","RefSeq","NP_001258425.1","17728180","Data suggest that the choline kinase alpha promoter has a distal element (-875/-867) that binds c-jun and the binding of c-jun is enhanced by treatment with CCl4."
< "O54804-1","RefSeq","NP_001258425.1","16490392","Full-length cDNAs or their truncated or alanine-mutated versions for mouse CK-alpha1 and CK-beta were expressed in COS-7 cells."
< "O54804-1","RefSeq","NP_001258425.1","11964179","Experimental evidence for the presence of heteromeric ChoK/EtnK in any source. The activity of ChoK/EtnK in the cell is controlled not only by the level of each isoform but also by their combination to form the active oligomer complex."
---
> "Q9D7M1-1","RefSeq","NP_083883.1","27920276","CD spectroscopy of recombinant TWA1 indicated a predominantly alpha-helical protein. Gel filtration chromatography, size-exclusion chromatography (SEC) with multi-angle light scattering (SEC-MALS) and native PAGE demonstrated a propensity of untagged TWA1 to form stable dimers and, to a lesser extent, higher order oligomers. Publication Status: Online-Only"
> "P28474-1","RefSeq","NP_031436.2","29860106","Site-directed mutagenesis of Akt at Cys224 revealed that S-nitrosylation at this site was pivotal for the reduced phosphorylation at Akt Ser473, which led to impaired Akt signaling. Furthermore, on HHcy challenge, as compared with GSNOR(+/+)ApoE(-/-) littermate controls, GSNOR(-/-)ApoE(-/-) double knockout mice showed reduced T-cell activation with concurrent reduction of atherosclerosis."
> "P28474-1","RefSeq","NP_031436.2","29074597","Data (including data from studies using knockout and transgenic mice) suggest that obesity and diabetes are accompanied by decreases in GSNOR activity in hepatocytes engendering nitrosative stress; obesity promotes S-nitrosylation of lysosomal proteins in liver, thereby impairing lysosomal enzyme activities and compromising autophagy."
> "P28474-1","RefSeq","NP_031436.2","28883020","Increased GSNOR expression during aging decreases S-nitrosation of CaMKIIalpha and reduces CaMKIIalpha synaptosomal accumulation."
> "P28474-1","RefSeq","NP_031436.2","28674030","These data indicate a role for GSNOR in the host response to malaria infection and suggest that strategies to disrupt its activity will improve clinical outcomes. Publication Status: Online-Only"
13388a17994,17998
> "P40237-1","RefSeq","NP_031682.1","30133344","Data provide evidence that CD82 is an important regulator of HSPC bone marrow maintenance, homing, and engraftment."
> "P40237-1","RefSeq","NP_031682.1","29782939","Loss of CD82 resulted in defects in osteoclast, osteoblast, and adipocyte lineages."
> "P40237-1","RefSeq","NP_031682.1","29760437","CD82-RUNX1-Rab5/22 axis may be a previously unrecognized virulence mechanism of Mycobacterium tuberculosis pathogenesis. Publication Status: Online-Only"
> "P40237-1","RefSeq","NP_031682.1","26996598","The CD82 is a functional surface marker of long-term repopulating hematopoietic stem cells (LT-HSCs) that maintains quiescence through interaction with DARC-expressing macrophages in the bone marrow stem cell niche."
> "P40237-1","RefSeq","NP_031682.1","16372335","An antibody to this protein that can specifically detect murine Kai1/CD82, should be useful in addressing the mechanism of action of Kai1 in metastatic suppression."
13410a18021
> "Q9WTS2-1","RefSeq","NP_058589.2","25979332","Loss of core fucosylation on AMPARs enhanced their heteromerization, which increase sensitivity for postsynaptic depolarization and persistently activate N-methyl-d-aspartate receptors as well as Ca(2+) influx and CaMKII and then impair LTP."
13413a18025,18026
> "Q61473-1","RefSeq","NP_035571.1","31073164","Study in a mouse endotoxemia model of inflammatory endothelial injury and human cells demonstrated that endothelial Sox17 expression plays an obligatory role in normalizing the endothelium. Restoration of endothelial integrity is mediated by activation of HIF-1alpha, upregulation of its target Sox17, and subsequent downstream expression of Cyclin E1 which mediates endothelial regeneration. Publication Status: Online-Only"
> "Q61473-1","RefSeq","NP_035571.1","11973269","Important role of Sox17 in endoderm development in the mouse"
13421a18035,18037
> "Q6PGK7-1","RefSeq","NP_660124.2","23269668","Chst10 likely functions in widespread regulation of steroid hormones in vivo"
> "Q6PGK7-1","RefSeq","NP_660124.2","17157030","These findings reveal alterations in ST-/- mice that differ from EEG abnormalities of mice deficient in the HNK-1 carrier molecule tenascin-R."
> "Q6PGK7-1","RefSeq","NP_660124.2","16262627","This study conclude that in ST-/- mice which show morphological, electrophysiological and behavioural abnormalities, the ECS is reduced and its geometry altered."
13423a18040,18045
> "Q9CXY9-1","RefSeq","NP_821135.1","9356492","The protein encoded by the human ortholog catalyzes the final step in glycosylphosphatidylinositol (GPI) anchoring of cell surface proteins, the transamidation reaction."
> "Q9QYI5-3","RefSeq","NP_835156.1","21832061","Hsc70, Hdj1 and Hdj2 interact with soluble and fibrillar alpha-synuclein"
> "Q9QYI5-3","RefSeq","NP_835156.1","20395441","Data show that DNAJB2 is expressed in skeletal muscle at the neuromuscular junction of normal fibers, in the cytoplasm and membrane of regenerating fibers, and in protein aggregates and vacuoles in protein aggregate myopathies."
> "Q9QYI5-3","RefSeq","NP_835156.1","16604191","Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase"
> "P63163-1","RefSeq","NP_038698.1","27430727","We found that either knockdown of Nr4a1 or 3, 3'- Diindolylmethane (DIM), an Nr4a1 antagonist, were able to rescue the effects of SNRPN knockdown on neurite outgrowth of embryonic cortical neurons, providing the potential therapeutic methods for SNRPN deletion disorders. We thus concluded that maintaining the proper level of SNRPN is critical in cortical neurodevelopment. Publication Status: Online-Only"
> "P63163-1","RefSeq","NP_038698.1","9294199","Snrpn gene is imprinted, with monoallelic expression from the paternal allele in brain and heart."
13432a18055,18058
> "Q8K0C5-1","RefSeq","NP_081194.1","27849619","The more penetrable Zg16(-/-) mucus allowed Gram-positive bacteria to translocate to systemic tissues. Viable bacteria were found in spleen and were associated with increased abdominal fat pad mass in Zg16(-/-) animals. The function of ZG16 reveals a mechanism for keeping bacteria further away from the host colon epithelium."
> "Q8K0C5-1","RefSeq","NP_081194.1","15097871","ZG16p mRNA is downregulated in chronic pancreatitis."
> "Q9Z0T9-1","RefSeq","NP_067334.1","26901152","Integrins alphavbeta6 and alphavbeta8 were expressed in non-overlapping patterns by keratinocytes and maintained the epidermal residence of Langerhans cells and tissue resident memory T cells by activating latent TGF-beta."
> "Q3U2K0-1","RefSeq","NP_663357.2","21177767","Expression of full length IRIZIO cDNA also cooperated with PAX3-FOXO1 in the transformation of Arf-/- myoblasts. Given that IRIZIO is expressed at increased levels in rhabdomyosarcoma, it might contribute to rhabdomyosarcomagenesis in humans."
13442,13444d18067
< "Q6KCD5-1","RefSeq","NP_081983.2","28041881","Depletion of Zfp609 or Nipbl from cortical neural progenitors in vivo is detrimental to neuronal migration. Zfp609 and Nipbl overlap at genomic binding sites independently of cohesin and regulate genes that control cortical neuron migration."
< "Q6KCD5-1","RefSeq","NP_081983.2","27606604","Nipbl transgenic mice display large atrial septal defects. Publication Status: Online-Only"
< "Q6KCD5-1","RefSeq","NP_081983.2","19763162","Mice heterozygous for a gene-trap mutation in Nipbl were produced and exhibited defects characteristic of Cornelia de Lange Syndrome."
13446a18070,18072
> "P45700-1","RefSeq","NP_032574.1","27856750","In the bound substrate complex, hydrophobic stacking interactions between Trp residues and the glycan core anchor the base of the glycan structure to the enzyme cleft"
> "P45700-1","RefSeq","NP_032574.1","21577142","Complex N-glycans generated by enzymes such as a-mannosidase I inhibit the activation of naive T cells."
> "P45700-1","RefSeq","NP_032574.1","17456197","Downregulation of TOAG-1 and alpha-1,2-mannosidase expression occurred in graft infiltrating cells and expression of both genes was also downregulated after T-cell activation in vitro"
13455,13456d18080
< "Q9QXL2-1","RefSeq","NP_001102510.1","29158259","Several key residues (i.e. Thr-1147, Leu-1152, Leu-1153, and Tyr-1154) at the C-terminal half of the KIF21A KBD peptide contact with the hydrophobic patch formed by Tyr-1176, Met-1209, Leu-1210, Leu-1213, and Leu-1248 from KANK1."
< "Q9QXL2-1","RefSeq","NP_001102510.1","22465342","The diffuse and widespread expression of KIF21A in the developing human and mouse central and peripheral nervous system as well as in extraocular muscle does not account for the restricted ocular phenotype observed in Congenital fibrosis of the extraocular muscles type 1."
13463,13464d18086
< "P43006-1","RefSeq","NP_001070982.1","29722912","Nerve injury-induced neuropathic pain was enhanced in spinal cord-specific GLT1 knockout mice but alleviated in periaqueductal gray (PAG)-specific GLT1 knockout mice. In addition, ceftriaxone upregulated GLT1 expression in the spinal cord, but not the PAG, of control mice and attenuated tactile hypersensitivity in nerve-injured control mice but not in nerve-injured spinal cord-specific GLT1 knockout mice."
< "P43006-1","RefSeq","NP_001070982.1","29880815","Data demonstrate that the interaction occurs between PS1 and GLT-1 expressed at their endogenous levels in vivo and in vitro, takes place in both neurons and astrocytes, and is independent of the PS1 autoproteolysis and gamma-secretase activity. Publication Status: Online-Only"
13466a18089,18090
> "Q8BGN5-1","RefSeq","NP_083271.1","19738379","Disruption of the Npal3 gene results in a pleiotropic phenotype; The function of the nervous system was impaired in both mutant males and females which could be demonstrated in behavioral tests and the the immune system is also affected. Erratum:[Cytogenet Genome Res. 2009;125(4):285. Hoelter, S M [corrected to Holter, S M]; Aguilar, A [corrected to Aguilar-Pimentel, A]; Gailus-Durne, V [corrected to Gailus-Durner, V]; Busch, D [corrected to Busch, D H]]"
> "Q9JHY4-1","RefSeq","NP_619626.1","12574366","The antibacterial protein SWAM1 is constitutively expressed in kidney and epididymis and inhibits the growth of both Escherichia coli and Staphylococcus aureus at an IC90 of 10 microM."
13467a18092,18093
> "Q8R502-1","RefSeq","NP_598658.1","21804215","These results indicate that fad158 is a key factor in the development of obesity and insulin resistance caused by a high-fat diet."
> "Q8R502-1","RefSeq","NP_598658.1","15184384","Fad158 has a role in regulating adipocyte differentiation"
13472a18099,18102
> "B2RXS4-1","RefSeq","NP_620088.2","28927892","Study data show that in vivo silencing of PlxnB2 alleviated imiquimod-induced psoriatic inflammation in the mouse model, indicating that PlxnB2 might be an important regulator in the inflammation of psoriasis."
> "B2RXS4-1","RefSeq","NP_620088.2","28467912","Germinal center recruitment of follicular T helper cells requires Plexin B2."
> "Q91W69-1","RefSeq","NP_082260.1","25122462","Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits. Publication Status: Online-Only"
> "Q91W69-1","RefSeq","NP_082260.1","21115825","Data suggest that epsin 3 cooperates with other bilayer binding proteins with curvature sensing/generating properties in the specialized traffic and membrane remodeling processes typical of gastric parietal cells"
13476a18107,18113
> "P63058-1","RefSeq","NP_835161.1","30292450","TRalpha seems to have an inhibitory impact on angiotensin (AGT) and AT1Ra expression, and loss of TRalpha function in TRalpha(0/0) mice increases tissue renin-angiotensin system expression in the aortic wall. More importantly, TRalpha deletion significantly increases vascular smooth muscle cells cholesterol content. Our results are consistent with a protective role of TRalpha against atherosclerosis."
> "P63058-1","RefSeq","NP_835161.1","29753845","Data suggest that gestational/maternal endocrine disruptor DEHP [di-(2-ethylhexyl) phthalate] exposure dose-dependently causes fetal IUGR (intrauterine growth restriction); mRNA levels of placental Thra1 and Thrb1 are reduced and nuclear translocation of placental Thra1 and Thrb1 is suppressed in DEHP-exposed mice."
> "P63058-1","RefSeq","NP_835161.1","29648626","Knockdown of the main TR in macrophages, TRalpha, impaired polarization into proinflammatory macrophages and amplified polarization into immunomodulatory macrophages."
> "P63058-1","RefSeq","NP_835161.1","30092589","Thyroid hormone receptor alpha deletion in ApoE-/- mice slightly increases the expression of tissue renin-angiotensin system in the aorta and aggravates the dysregulation of cholesterol content in the vascular smooth muscle cells."
> "Q6DIC6-1","RefSeq","NP_001277699.1","23194061","The expression of trophinin in the mouse sperm tail causes a significant increase in sperm motility. Publication Status: Online-Only"
> "Q6DIC6-1","RefSeq","NP_001277699.1","15162511","Maged3 expression is restricted to the central nervous system where it was mostly detected in postmitotic neurons"
> "Q6DIC6-1","RefSeq","NP_001277699.1","11804944","Targeted disruption of the trophinin gene in the mouse showed a partial embryonic lethality in a 129/SvJ background"
13491,13496d18127
< "Q5EE38-1","RefSeq","NP_001012656.1","30189268","Analyses demonstrate that the majority of differentially expressed genes in acd mutant embryos are due to p53-dependent mechanisms and reflect the observed phenotypic differences between acd mutant and double mutant embryos."
< "Q5EE38-1","RefSeq","NP_001012656.1","29386102","Show that TPP1 NOB is critical for telomerase function and demonstrate that the telomerase interaction surface on TPP1 is more elaborate than previously appreciated"
< "Q5EE38-1","RefSeq","NP_001012656.1","24469404","Shelterin protein TIN2 can protect chromosome ends as a TRF2-tethered TIN2/TPP1/POT1 complex that lacks a physical connection to TRF1"
< "Q5EE38-1","RefSeq","NP_001012656.1","24316971","Mouse hematopoietic stem cells are acutely sensitive to inactivation of the shelterin gene Acd."
< "Q5EE38-1","RefSeq","NP_001012656.1","17632522","Tpp1 is required for the protective function of Pot1 proteins. Erratum:[Nat Struct Mol Biol. 2009 May;16(5):572]"
< "Q5EE38-1","RefSeq","NP_001012656.1","15537664","Telomeric regulator is required for proper urogenital ridge differentiation, axial skeleton specification and limb patterning in mice."
13499a18131,18133
> "O54879-1","RefSeq","NP_032279.1","22241470","Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition."
> "O54879-1","RefSeq","NP_032279.1","22912879","Data indicate that myomiR-206 modulates Hmgb3 expression during myogenesis."
> "O54879-1","RefSeq","NP_032279.1","12082634","Overexpression of the HMGA2 gene in transgenic mice leads to the onset of mixed growth hormone/prolactin cell pituitary adenomas."
13532a18167,18168
> "Q62159-1","RefSeq","NP_031510.2","29113998","What was seen for RhoC, mDia1 silencing through RNAi inhibited phagosome formation. Additionally, the coexpression of mDia1 with constitutively active mutant RhoC-G14V or expression of active mutant mDia1-DeltaN3 drastically inhibited the uptake of IgG-Es. These data suggest that RhoC modulates phagosome formation be modifying actin cytoskeletal remodeling via mDia1"
> "Q62159-1","RefSeq","NP_031510.2","27269051","RhoC co-localizes with Fam65b in stereocilia and regulates Fam65b oligomerization what is critical for hair cell function. Publication Status: Online-Only"
13536,13540d18171
< "Q80TJ7-1","RefSeq","NP_001106825.1","29317619","PHD zinc finger 8 protein (Phf8) knockout mice display normal brain development but impaired learning and memory, and compromised long-term potentiation (LTP) in the hippocampus. Publication Status: Online-Only"
< "Q80TJ7-1","RefSeq","NP_001106825.1","28485378","These results clarify the functional role of Phf8 in mammalian development and behavior. Publication Status: Online-Only"
< "Q80TJ7-1","RefSeq","NP_001106825.1","26866517","Knockdown of pmaip1 mimicked the phenotype of ph8(-/Y) by showing the decreased apoptosis during early differentiation of embryonic stem cells and promoted mesodermal and cardiac commitment."
< "Q80TJ7-1","RefSeq","NP_001106825.1","25921086","PHF8 overexpression reversed cardiac dysfunction, hypertrophy and fibrosis upon pressure overload in PHF8 transgenic mice."
< "Q80TJ7-1","RefSeq","NP_001106825.1","16199551","An important function of PHF8 is in midline formation and in the development of cognitive abilities, and may have a role in X linked mental retardation associated with cleft lip/palate"
13556a18188,18192
> "Q7TNL9-1","RefSeq","NP_780538.2","16893530","Nur77 gene knockout alters dopamine neuron biochemical activity and dopamine turnover."
> "Q7TNL9-1","RefSeq","NP_780538.2","16051191","In the presence of HA1004, NBRE binding by Nur77 protein increases with time (6 h vs 2 h), whereas the final outcome of both inhibitors is apoptosis of thymic lymphoma cells."
> "P43883-1","RefSeq","NP_031434.3","29866659","Perilipin-2 deletion promotes carbohydrate-mediated browning of white adipose tissue at ambient temperature"
> "P43883-1","RefSeq","NP_031434.3","29099637","Although lipopolysaccharide (LPS) can trigger inflammation in atherosclerosis, how LPS promotes atherogenesis through acting on macrophages is not very clear. Here, we study the role of adipophilin in LPS-induced inflammation.  LPS can promote the expression of adipophilin through the ERK1/2-PPARgamma pathway."
> "P43883-1","RefSeq","NP_031434.3","29045046","Lipid-laden fibroblasts (lipofibroblasts) express the Perilipin 2 (Plin2) gene-product, PLIN2, commonly called adipose-differentiation related protein (ADRP)..The present study reports the generation of an inducible mouse Cre-driver line to target cells of the ADRP lineage. Robust Cre-mediated recombination in this mouse line was detected in mesenchymal cells of the postnatal lung"
13559a18196,18200
> "Q91XQ5-1","RefSeq","NP_084211.2","27410685","Blockade CHST15 represses colonic fibrosis Publication Status: Online-Only"
> "Q91XQ5-1","RefSeq","NP_084211.2","23555092","GalNAc4S-6ST play a crucial role in pulmonary metastasis at least through the increased adhesion and the invasive capacity of LLC cells and also provides insights into future drug targets for anticancer treatment."
> "Q91XQ5-1","RefSeq","NP_084211.2","17051481","GalNAc4S-6ST has a role during early mouse development"
> "P55288-1","RefSeq","NP_033996.4","30509494","CDH11 promotes liver fibrosis by activating hepatic stellate cells"
> "P55288-1","RefSeq","NP_033996.4","30359089","Cadherin-11 influences valvular interstitial cell contractility by regulating focal adhesions and inflammatory cytokine secretion."
13562a18204,18207
> "Q3UUG6-1","RefSeq","NP_775278.3","30335140","We then further investigated TBC1D24 haploinsufficiency in vivo and demonstrate that TBC1D24 is also crucial for normal presynaptic function: genetic disruption of Tbc1d24 expression in the mouse leads to an impairment of endocytosis and an enlarged endosomal compartment in neurons with a decrease in spontaneous neurotransmission."
> "Q3UUG6-1","RefSeq","NP_775278.3","24729547","That the p.Ser178Leu mutation of TBC1D24 is a probable cause for dominant, nonsyndromic hearing impairment. Identification of TBC1D24 as the stereocilia-expressing gene may shed new light on its specific function in the inner ear."
> "Q3UUG6-1","RefSeq","NP_775278.3","20797691","A pathogenic mutation was identified in TBC1D24."
> "Q3UUG6-1","RefSeq","NP_775278.3","20727515","Two compound heterozygous missense mutations (D147H and A509V) in TBC1D24, a gene of unknown function, are responsible for familial infantile myoclonic epilepsy."
13569c18214,18216
< "Q3UEI1-1","RefSeq","NP_001297394.1","21670265","Findings identify PC2 and PDE4C as unique components of an AKAP complex in primary cilia and reveal a common mechanism for dysregulation of cAMP signaling in cystic kidney diseases arising from different gene mutations"
---
> "Q9WTV7-1","RefSeq","NP_035406.3","30420655","RNF12 targets pluripotency protein REX1 for degradation to initiate random X chromosome inactivation in embryonic stem cells. Publication Status: Online-Only"
> "Q9WTV7-1","RefSeq","NP_035406.3","29650591","These findings show that control of Lhx2 function by Ldb1 and Rnf12 underpins the coordinated differentiation of neurons and Muller glia in postnatal retina. Publication Status: Online-Only"
> "Q9WTV7-1","RefSeq","NP_035406.3","29281819","The existence of Rlim-dependent and Rlim-independent pathways for random X chromosome inactivation in differentiating female embryonic stem cells."
13578a18226,18236
> "Q78JE5-1","RefSeq","NP_082325.2","26868148","Results indicate that SCF(Fbxo22)-KDM4A is an E3 ubiquitin ligase that targets methylated p53 and regulates key senescent processes. Publication Status: Online-Only"
> "Q61335-1","RefSeq","NP_036190.2","29113994","It findings demonstrate that BAP31-deletion induces SREBP activation and promotes hepatic lipid accumulation, reduces insulin signaling, impairs glucose/insulin tolerance, and increases ER stress and hepatic inflammation, explaining the protective roles of BAP31 in the development of liver steatosis and insulin resistance in HFD-induced obesity in animal models."
> "Q61335-1","RefSeq","NP_036190.2","30504720","Both the mRNA and protein levels of Valosin-Containing Protein were regulated by Bap31 in vivo and in vitro."
> "Q61335-1","RefSeq","NP_036190.2","28333124","These results demonstrate that BAP31 may play an important role in T cell activation by regulating TCR signaling. Publication Status: Online-Only"
> "Q61335-1","RefSeq","NP_036190.2","26102500","The C-terminal domain of BAP31 is exposed on the cell surface of mouse embryonic stem cells. Erratum:[PLoS One. 2017 Jan 6;12 (1):e0170145. PMID: 28061503] Publication Status: Online-Only"
> "Q61335-1","RefSeq","NP_036190.2","24139803","BAP31/CDIP1-mediated regulation of mitochondrial apoptosis pathway represents a mechanism for establishing an ER-mitochondrial crosstalk for ER-stress-mediated apoptosis."
> "Q61335-1","RefSeq","NP_036190.2","12886015","A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum."
> "Q63994-1","RefSeq","NP_067268.1","25320078","Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs."
> "Q63994-1","RefSeq","NP_067268.1","24227736","CD33-related Siglec-E recognizes the intact neuron and has neuroprotective function by preventing phagocytosis."
> "Q63994-1","RefSeq","NP_067268.1","17008544","SOCS3 inhibited the CD33-induced block on cytokine-induced proliferation. SOCS3 and its target protein CD33 are degraded concomitantly concomitantly."
> "Q63994-1","RefSeq","NP_067268.1","12773563","MCD33 is expressed on myeloid precursors in the bone marrow"
13585a18244,18247
> "P70365-1","RefSeq","NP_035011.1","30979869","SRC-1 modulates the function of hypothalamic Pomc neurons Publication Status: Online-Only"
> "P70365-1","RefSeq","NP_035011.1","30451821","Sumoylation of RORgammaT regulates TH17 differentiation and thymocyte development via histone acetyltransferase KAT2A, which stabilizes the binding of SRC1 to enhance RORgammaT transcription factor activity. Publication Status: Online-Only"
> "P70365-1","RefSeq","NP_035011.1","28816099","Although the SRC-1 expression in female mice was lower than that in males under normal conditions, its expression in females was more dominant after spinal cord injury. The expression of Profilin-1 in both sexes increased first, and then decreased at 3 days after injury. However, there was a second increase in females at 7 days after injury."
> "P70365-1","RefSeq","NP_035011.1","28579428","The results suggest that biochanin A activates RORgamma-dependent IL-17 transcription through the enhancement of STAT3 phosphorylation and STAT3-mediated recruitment of NCOA1 to RORgamma."
13599a18262,18267
> "Q9R0B9-1","RefSeq","NP_036091.2","28378777","FKBP65 regulates LH2-mediated collagen cross-linking. Publication Status: Online-Only"
> "Q9R0B9-1","RefSeq","NP_036091.2","27803159","The finding that LH2 modifies collagen in the extracellular space challenges the current view that LH2 functions solely on the endoplasmic reticulum and could also have important implications for cancer biology."
> "Q9R0B9-1","RefSeq","NP_036091.2","23069856","Authors propose that lysyl hydroxylase 2, and the subsequent increase in pyridinoline cross-links, is responsible for the persistent fibrosis in experimental osteoarthritis."
> "Q8CG64-1","RefSeq","NP_775606.1","19155270","Results suggest the generation of a mouse model for FKRP related muscular dystrophy requires a knock-down rather than a knock-in strategy in order to give rise to a disease phenotype."
> "Q8CG64-1","RefSeq","NP_775606.1","17452335","Data offer the first evidence of a fukutin-related protein (FKRP) complex in muscle and suggest that FKRP may influence the glycosylation status of dystroglycan from within the sarcolemmal dystrophin-glycoprotein complex"
> "Q8CG64-1","RefSeq","NP_775606.1","15837576","Basement membrane (BM) fragility may underlie abnormal phenotypes in fukutin-null embryos, and maintenance of BM function may require fukutin-mediated glycosylation of alpha-dystroglycan early in embryonic development."
13605a18274
> "Q64700-1","RefSeq","NP_035380.3","28550162","Findings indicate that inactivation of the Rb family proteins (Rb, p107, and p130) in hematopoietic stem cells (HSCs) progressively impairs their homeostasis, which is rescued upon repression of suppressor of cytokine signaling 3 protein (Socs3) expression in triple knockout (TKO) HSCs."
13622a18292,18294
> "O55143-1","RefSeq","NP_033852.1","30717322","For the in vivo study, BALB/c mice were treated with ATO and/or Sal A via daily tail vein injections for two weeks... Sal A increased sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA) activity and expression, alleviated [Ca(2+)]ER depletion, and decreased ER stress-related protein expression Publication Status: Online-Only"
> "O55143-1","RefSeq","NP_033852.1","30299255","Here the show that DWORF has a higher apparent binding affinity for SERCA than PLN and that DWORF overexpression mitigates the contractile dysfunction associated with PLN overexpression, substantiating its role as a potent activator of SERCA. Publication Status: Online-Only"
> "O55143-1","RefSeq","NP_033852.1","29986885","These data demonstrate that the activity of RyR2, but not SERCA2a, is a major determinant of Ca2+ alternans in intact working mouse hearts."
13627a18300,18305
> "Q80VP1-1","RefSeq","NP_034277.1","30102256","Diabetes attenuated VEGF-C-induced lymphangiogenesis in corneal micropocket and Matrigel plug assays in WT mice but not in mice with inducible lymphatic-specific deficiency of epsins 1 and 2 (LEC-iDKO)."
> "Q80VP1-1","RefSeq","NP_034277.1","25871009","Epsins are required for Dishevelled stability and Wnt signalling activation in colon cancer development. Publication Status: Online-Only"
> "Q80VP1-1","RefSeq","NP_034277.1","25314967","Epsins 1 and 2 have a critical role in the temporal and spatial regulation of VEGFR3 abundance and signaling in collecting lymphatic trunks during lymphatic valve formation Publication Status: Online-Only"
> "Q80VP1-1","RefSeq","NP_034277.1","23187125","Loss of epsins 1 and 2 impaired endocytosis and degradation of VEGFR2, resulting in excessive VEGF signaling and compromised tumor vascular function."
> "Q80VP1-1","RefSeq","NP_034277.1","19666558","Epsin has a role as a specialized endocytic adaptor, with a critical role in the activation of Notch signaling in mammals"
> "Q80VP1-1","RefSeq","NP_034277.1","16574660","Epsin is an accessory protein linking ENaC to the clathrin-based endocytic machinery thereby regulating the activity of this ion channel at the cell surface"
13635a18314,18315
> "Q6RKD8-1","RefSeq","NP_958813.1","28475893","Mice with deletions of FLRT1 and FLRT3 adhesion molecules develop macroscopic sulci with preserved layered organization and radial glial morphology. Cortex folding in these mutants does not require progenitor cell amplification but is dependent on changes in neuron migration."
> "Q6RKD8-1","RefSeq","NP_958813.1","16872596","FLRT1 is expressed at brain compartmental boundaries in embryo"
13639a18320,18322
> "Q8VHK9-1","RefSeq","NP_082412.2","25611385","The ablation of RHAU in germ cells caused the increase of G4 structures and thus resulted in the decrease of spermatogonial differentiation. Publication Status: Online-Only"
> "Q8VHK9-1","RefSeq","NP_082412.2","22422825","RHAU deletion in hematopoietic system caused hemolytic anemia and differentiation defect at the proerythroblast stage. RHAU may play a role in the regulation of gene expression that relies on its G4 resolvase activity."
> "Q8VHK9-1","RefSeq","NP_082412.2","21703541","DDX1-DDX21-DHX36 complex represents a dsRNA sensor that uses the TRIF pathway to activate type I IFN responses in the cytosol of myeloid dendritic cells"
13652a18336,18340
> "P61965-1","RefSeq","NP_543124.1","27346354","Cbx8 associates with non-PRC1 complexes containing the H3K4 methyltransferase complex component WDR5, which together regulate Notch gene expression."
> "P61965-1","RefSeq","NP_543124.1","26505193","Wdr5 suppression also reduced IFNgamma, Il-1beta, and TNFalpha induced chemokine gene expression in b-cells without affecting islet-cell survival or b-cell function after 48hrs, but did begin to increase islet-cell apoptosis Publication Status: Online-Only"
> "P61965-1","RefSeq","NP_543124.1","16730692","Wdr5 accelerates osteoblast differentiation in association with activation of the canonical Wnt pathway."
> "P61965-1","RefSeq","NP_543124.1","15860628","Identified two proteins, NONO and WDR5, that can associate with the mammalian PER1 protein; WDR5 augmented PER-mediated transcriptional repression, and its reduction by RNAi diminished circadian histone methylations at the promoter of a clock gene"
> "P61965-1","RefSeq","NP_543124.1","14657013","BIG-3 accelerates chondrocyte differentiation in vitro, and is expressed in the growth plate during embryonic development, so is is likely to play an in vivo regulatory role in the developing growth plate."
13653a18342,18346
> "Q8K1M6-1","RefSeq","NP_690029.2","30632304","DRP1 translocation to the mitochondria is necessary for insulin resistance induced by high fat diet.Tafazzin contributes to insulin resistance via mediating DRP1 translocation to the mitochondria"
> "Q8K1M6-1","RefSeq","NP_690029.2","30475154","Drp1-dependent mitochondrial fission regulates p62-mediated autophagy in LPS-induced activated microglial cells"
> "Q8K1M6-1","RefSeq","NP_690029.2","30918582","Chronically elevated IL-6 can directly induce DRP-1 and FIS-1 expression through gp130 signaling in cultured myotubes and skeletal muscle. Publication Status: Online-Only"
> "Q8K1M6-1","RefSeq","NP_690029.2","30531964","Data suggest that dynamin-related protein 1 (Drp1) has both membrane constricting and severing abilities and is the dominant dynamin performing mitochondrial and peroxisomal fission. Publication Status: Online-Only"
> "Q8K1M6-1","RefSeq","NP_690029.2","19349686","Mitochondrial fragmentation in acute kidney injury involves the activation of mitochondrial fission via Drp1."
13657a18351,18354
> "Q61146-1","RefSeq","NP_032782.1","29675597","Adherens as well as tight junction marker proteins were rapidly and consistently upregulated in both the germinal as well as the functional layer of the oral mucosa. This represents a previously unknown parameter of the epithelial radiation response to clinically relevant fractionation protocols. CONCLUSION: Fractionated irradiation significantly enhanced the expression of all proteins investigated. This study revealed a"
> "P62827-1","RefSeq","NP_033417.1","28205572","Depleting TPX2 decreases microtubule formation frequency specifically at the tip and the base of the neurite, and these correlate precisely with the regions where active GTP-bound Ran proteins are enriched. Publication Status: Online-Only"
> "P62827-1","RefSeq","NP_033417.1","25155018","Augmented expression of Ran in progranulin-deficient neurons restores nuclear TDP-43 levels and improves their survival."
> "P62827-1","RefSeq","NP_033417.1","24068924","Data suggest Ran activation by RanBP1 in macrophages promotes Legionella phagosome formation and phagocytosis; LegG1 functions as bacterial Ran activator, localizes to phagosomes, and promotes microtubule stabilization, phagocytosis, and replication."
13664,13666c18361,18363
< "Q60651-1","RefSeq","NP_001239506.1","27438766","This study shows that after mouse cytomegalovirus infection, Ly49D augmented IFN-gamma production by virus-specific Ly49H(+) NK cells and preferentially promoted the generation of memory Ly49H(+) NK cells"
< "Q60651-1","RefSeq","NP_001239506.1","19247984","These data demonstrate that DAP10 does associate with Ly49H and Ly49D in primary NK cells."
< "Q60651-1","RefSeq","NP_001239506.1","19109149","Ly49D stimulation triggers cellular activation of CD4 and CD8 populations; Ly49D recognizes the classical hamster class I molecule Hm1-C4 on CHO cells, as demonstrated by the killing of Hm1-C4-transfected thymoma cells by Ly49D cytotoxic T cells."
---
> "Q91WD8-1","RefSeq","NP_659062.1","26246500","The deletion of NCKX1 in mice results in malformed outer segment disks, suppressed expression and function of rod cGMP-gated channels and a subsequent 100-fold reduction in rod responses, while preserving normal cone responses."
> "Q9QZS3-1","RefSeq","NP_035079.1","30262992","Data show the expression of Zeb1 and Numb were both significantly higher in LLC-symmetric cell division than LLC-asymmetric cell division cells. Publication Status: Online-Only"
> "Q9QZS3-1","RefSeq","NP_035079.1","14641329","MNumb splicing isoform has an inhibitory effect on Notch signaling, indicating its potential roles in the differentiation of pancreatic endocrine lineage."
13670a18368,18369
> "Q9QVP9-1","RefSeq","NP_001155838.1","30433799","Pyk2 is involved in the process of colonic smooth muscle contraction through the RhoA/ROCK pathway."
> "Q9QVP9-1","RefSeq","NP_001155838.1","30664624","The study results reveal a possible role for Pyk2 in the response to stress and in synaptic markers expression and spine density regulation in the amygdala. It suggests that Pyk2 contributes to stress-induced responses through micro-structural changes and that its deficit may contribute to the resilience to chronic stress. Publication Status: Online-Only"
13671a18371,18382
> "Q80VW7-1","RefSeq","NP_001292361.1","21606955","Targeted deletions of mouse AKNA, a hypothetical AT-hook-like transcription factor, sensitize mice to pathogen-induced inflammation and cause sudden neonatal death"
> "Q9CQ89-1","RefSeq","NP_081224.1","19645739","An N-terminal CutA domain actually drives AChE into the endoplasmic reticulum and allows its secretion"
> "Q3UM89-1","RefSeq","NP_001030066.1","15202009","FOXN6 gene was identified within genome sequence RP23-180D16 (FOXN6)"
> "Q9D2A5-1","RefSeq","NP_084356.1","30121191","Tisp40 deficiency limits renal inflammation and promotes tubular cell proliferation in renal ischemia reperfusion injury."
> "Q9D2A5-1","RefSeq","NP_084356.1","28778797","Tisp40 aggravates tubular cells apoptosis in renal ischemia reperfusion injury."
> "Q9D2A5-1","RefSeq","NP_084356.1","28618421","These findings suggest that Tisp40 plays a critical role in the TGF-beta/ Smads pathway involved in this process. Hence, Tisp40 could be a useful therapeutic target in the fight against renal tubulointerstitial fibrosis"
> "Q9D2A5-1","RefSeq","NP_084356.1","25412305","Creb3l4 is an essential negative regulator of adipogenesis. Publication Status: Online-Only"
> "Q9D2A5-1","RefSeq","NP_084356.1","16925989","Expression of full-length ATCE1 in various cell lines revealed ER and Golgi localization whereas truncation of the C-terminus allowed entrance into the nucleus. A speculation that ATCE1 might be paternally delivered to newly formed zygote is discussed."
> "Q9D2A5-1","RefSeq","NP_084356.1","16728718","We show that Atce1/Tisp40alpha is the major form of CREB3L4 in mouse testis. These findings suggest that testis-specific isoforms of Creb3l4 could play an important role in spermatid differentiation."
> "Q9D2A5-1","RefSeq","NP_084356.1","16595651","Tisp40 and CREM bind to the Tisp40 promoter in vivo"
> "Q9D2A5-1","RefSeq","NP_084356.1","16107712","Creb3l4 plays a role in male germ cell development"
> "Q9D2A5-1","RefSeq","NP_084356.1","15938716","TISP40 functions by binding to the unfolded protein response element via the Rip pathway."
13675,13677c18386,18396
< "Q9R0N7-1","RefSeq","NP_061271.1","29957297","Synaptotagmin-7 plays a significant role in the vesicle pool homeostasis and consequently, in the availability of vesicles for synaptic transmission."
< "Q9R0N7-1","RefSeq","NP_061271.1","29771357","While halofuginone did not affect patch-repair-complex key proteins, it further enhanced Syt-7 levels and its spread across the cytosol in dysf-/- myofibers and muscle tissue, and increased its co-localization with lysosomes. Together, the data imply a novel role for halofuginone in membrane-resealing events with Syt-7 possibly taking part in these events."
< "Q9R0N7-1","RefSeq","NP_061271.1","12071850","Identified the conserved alternative splicing events in the spacer domain of Syt VII; also shown that Syt VIIa-GFP is mainly localized in the perinuclear region and tips of neurites (dense-core vesicles), and not in the plasma membrane"
---
> "Q8K370-1","RefSeq","NP_082313.2","28120165","Acad10 mice accumulate excess abdominal adipose tissue, develop an early inflammatory liver process, exhibit fasting rhabdomyolysis, and have abnormal skeletal muscle mitochondria. Identify Acad10 as a genetic determinant of type 2 diabetes in mice."
> "P70426-1","RefSeq","NP_033095.1","30898653","We generated a novel knock-in Rit1A57G/+ mouse that presents features that are relevant to NS patients with a Rit1 mutation, including craniofacial dysmorphia, short stature, and cardiac hypertrophy."
> "P70426-1","RefSeq","NP_033095.1","29843527","RIT1 is widely expressed in the murine retina, including both Muller glia and RGCs. While genetic deletion of RIT1 does not result in gross retinal abnormalities"
> "P70426-1","RefSeq","NP_033095.1","28007959","In adult hippocampal neuronal precursor cells, RIT1 controls an Akt-dependent signaling cascade, resulting in the stabilization and transcriptional activation of phosphorylated Sox2. This study supports a role for RIT1 in relaying niche-derived signals to neural/stem progenitor cells to control transcription of genes involved in self-renewal and differentiation"
> "P70426-1","RefSeq","NP_033095.1","22815504","These data identify a new and unexpected role for Rit in injury-induced neurogenesis, functioning as a selective survival mechanism for immature hippocampal neurons within the subgranular zone of the dentate gyrus following TBI."
> "P70426-1","RefSeq","NP_033095.1","21737674","Our studies establish the Rit GTPases as critical regulators of an evolutionarily conserved, p38 MAPK-dependent signaling cascade"
> "P70426-1","RefSeq","NP_033095.1","15831491","Rin and Rit Bind to PAR6 GTP-dependently and regulate cell transformation"
> "Q62315-1","RefSeq","NP_068678.1","30700554","This study demonstrates that ablation of Jarid2 in cardiomyocytes results in dilated cardiomyopathy and suggest that Jarid2 plays important roles in cardiomyocyte maturation during neonatal stages."
> "Q62315-1","RefSeq","NP_068678.1","30423295","In this study, genetic mouse models and patient-derived xenografts demonstrated that JARID2 acts as a tumor suppressor in chronic myeloid disorders."
> "Q62315-1","RefSeq","NP_068678.1","30119689","JARID2 regulates muscle differentiation by modulating Wnt signaling through direct repression of SFRP1. Publication Status: Online-Only"
> "Q62315-1","RefSeq","NP_068678.1","29891551","The deletion of Jarid2 by Nkx2.5-Cre mice (Jarid2(Nkx)) caused cardiac malformations including ventricular septal defects, thin myocardium, hypertrabeculation, and neonatal lethality. Jarid2(Nkx) mice exhibited elevated expression of neural genes, cardiac jelly, and other key factors including Isl1 and Bmp10 in the developing heart."
13682a18402,18413
> "Q5SWZ9-1","RefSeq","NP_898962.2","29113556","PLD6 is a surface marker of undifferentiated spermatogonia in testes."
> "Q5SWZ9-1","RefSeq","NP_898962.2","28749988","The Dnmt3l mutation greatly reduced DNA methylation levels at most retrotransposons, but its impact on their RNA abundance was limited in prospermatogonia. In Pld6 mutant germ cells, although only a few retrotransposons exhibited reduced DNA methylation, many showed increased expression at the RNA level. Publication Status: Online-Only"
> "Q5SWZ9-1","RefSeq","NP_898962.2","28115634","MIWI (or PIWIL1) depletion had a smaller effect. In oocytes lacking PLD6 (or ZUCCHINI or MITOPLD), a mitochondrial nuclease/phospholipase involved in piRNA biogenesis in male germ cells, the piRNA level was decreased to 50% compared to wild-type."
> "Q5SWZ9-1","RefSeq","NP_898962.2","27635761","Drp1 binds a mitochondrial enzyme that produces phosphatidic acid, MitoPLD, and regulates mitochondrial division."
> "Q5SWZ9-1","RefSeq","NP_898962.2","26711011","Propose that MIGA proteins promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD."
> "Q5SWZ9-1","RefSeq","NP_898962.2","23064227","Crystal structure of mZuc at 1.75 A resolution indicates greater architectural similarity to phospholipase-D family nucleases than to phospholipases; data suggest that the Zucchini proteins act in primary piRNA biogenesis as nucleases, perhaps generating the 5' ends of primary piRNAs."
> "Q5SWZ9-1","RefSeq","NP_898962.2","22281006","MitoPLD performs a critical function in a pathway that creates a specialized form of RNAi required by developing spermatocytes to suppress transposon mobilization during meiosis. Review article"
> "Q5SWZ9-1","RefSeq","NP_898962.2","21397848","Data suggest that mitochondrial-surface phosphatidic acid generated by MitoPLD/Zuc recruits or activates nuage components critical for piRNA production."
> "Q5SWZ9-1","RefSeq","NP_898962.2","21397847","Results indicate a conserved role for MITOPLD/Zuc in the piRNA pathway and link mitochondrial membrane metabolism/signaling to small RNA biogenesis."
> "Q8R516-1","RefSeq","NP_660106.2","21896478","Identify MIB2 as a novel component of the activated BCL10 signaling complex and a missing link in the BCL10-dependent NF-kappaB signaling pathway."
> "Q8R516-1","RefSeq","NP_660106.2","17987667","Created a targeted mutation of Mib2 and show that its phenotype is a variable penetrance, failure to close the cranial neural tube"
> "Q8R516-1","RefSeq","NP_660106.2","15824097","Mib2 has functional similarities to Mib1, but might have distinct roles in Notch signaling as an E3 ubiquitin ligase"
13704a18436,18438
> "Q9R117-1","RefSeq","NP_061263.2","28668884","Results show that loss of TYK2 does not affect disease severity of JAK2VF-induced murine myeloproliferative neoplasms (MPN) indicating that TYK2 has no cooperative effects with JAK2VF at the onset of MPN."
> "Q9R117-1","RefSeq","NP_061263.2","27802075","Mutated form which lacks tyrosine kinase activity restores differentiation of brown preadipocytes"
> "Q9R117-1","RefSeq","NP_061263.2","27807284","TYK2 genetic variants are differentially associated with common autoimmune diseases"
13709a18444,18446
> "O08992-1","RefSeq","NP_058087.2","29408273","Our results suggest that syntenin-1 plays an important role in extinction of cued fear memory by modulating neuronal activity in the basolateral amygdala and infralimbic cortex."
> "O08992-1","RefSeq","NP_058087.2","28418925","These findings demonstrate that syntenin promotes VEGF signaling and, through its PDZ-dependent interaction with ephrin-B2, enhances VEGF-mediated VEGFR2 endocytosis and subsequent downstream signaling and angiogenesis in endothelial cells"
> "O08992-1","RefSeq","NP_058087.2","27341128","Present study is the first demonstration of the relevance of MDA-9/Syntenin expression in regulating inflammation and immunosuppression in the microenvironment thereby impacting tumor growth and metastasis in mouse melanoma model."
13710a18448
> "Q9Z238-1","RefSeq","NP_033960.1","29551768","High CCNE2 expression is associated with hepatitis and hepatocarcinogenesis."
13718a18457,18462
> "Q8BIF0-1","RefSeq","NP_612182.1","29791026","Conditional Tie-2-Cre driven gene inactivation of CD99L2 inhibits leukocyte entry into the CNS during active MOG35-55 -induced experimental autoimmune encephalomyelitis and alleviates severity of the disease. CD99L2 participates in the development of EAE by supporting diapedesis of leukocytes through the endothelial basement membrane of blood vessels of the BBB in the CNS."
> "Q8BIF0-1","RefSeq","NP_612182.1","26321243","Mice lacking CD99L2 had a defective inflammatory response in the thioglycollate peritonitis model"
> "Q8BIF0-1","RefSeq","NP_612182.1","23338758","The present study provides data for further investigation into the mCD99L2 gene in tumor cells."
> "Q8BIF0-1","RefSeq","NP_612182.1","23293350","CD99L2 is an essential endothelial Ag for leukocyte extravasation, which does not require homophilic interactions with CD99L2 on leukocytes."
> "Q8BIF0-1","RefSeq","NP_612182.1","18163232","Transfection of L cell fibroblasts with CD99L2 imparted to them the ability to adhere to each other in a divalent cation-dependent, homophilic manner. Anti-CD99L2 antibody blocked influx of neutrophils and monocytes into a site of inflammation in vivo."
> "Q8BIF0-1","RefSeq","NP_612182.1","17344467","Expressed on mouse leukocytes and endothelial cells and is involved in transendothelial migration of neutrophils in vitro and in the recruitment of neutrophils into inflamed peritoneum"
13723a18468,18477
> "Q9JJC8-1","RefSeq","NP_076136.2","18667602","The isolation and characterization of Nipa2 in mouse distal convoluted tubule cells are reported."
> "Q9JJC8-1","RefSeq","NP_076136.2","14508708","Indentification on mouse chromosome 7C"
> "Q03526-1","RefSeq","NP_034713.2","29129599","Inhibition of ITK and RLK attenuated psoriasis-associated signaling pathways, indicating that PRN694 is an effective psoriasis therapeutic."
> "Q03526-1","RefSeq","NP_034713.2","28635957","ITK signalling through the Ras/IRF4 pathway is required for functional development of type 1 regulatory T cells. Publication Status: Online-Only"
> "Q03526-1","RefSeq","NP_034713.2","28516764","Data suggest that the pleckstrin homology domain of Itk functions as a phospholipid bilayer recognition site that localizes Itk to membrane via phosphatidylinositol 3,4,5-trisphosphate (PIP3) binding; this specific binding inhibits the phospho-transfer reaction via an allosteric mechanism."
> "Q03526-1","RefSeq","NP_034713.2","28406139","Data show that interleukin-2 inducible T cell kinase (Itk)negatively regulates the development of nTh1 cells that express interferon-gamma (IFNgamma) in a T-bet transcription factor (Tbet) independent manner. Publication Status: Online-Only"
> "Q03526-1","RefSeq","NP_034713.2","28213500","Our results provide new insight into the effect of ITK and suboptimal T-cell receptor signaling on CD8(+) T cell function, and how these may contribute to phenotypes associated with ITK deficiency"
> "Q8R5L3-1","RefSeq","NP_849182.1","20961651","Our data indicate that TRAP1 and VPS39 are nonredundant and essentially required for early embryonic development"
> "Q8R5L3-1","RefSeq","NP_849182.1","20363736","Although only TBC1D15/Rab7-GAP altered Rab7-GTP levels, both Rab7-GAP and mVps39 regulate lysosomal morphology and play a role in maintaining growth factor dependence"
> "Q8R5L3-1","RefSeq","NP_849182.1","15110766","Antibodies to VAMP and SNAP inhibited sperm-zona pellucida interaction, suggesting their possible involvement in sperm membrane vesiculation."
13725a18480,18481
> "B1AQJ2-1","RefSeq","NP_001028700.1","29273634","Usp36 is essential for cell and organism viability because of its role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, by regulating DHX33 stability."
> "B1AQJ2-1","RefSeq","NP_001028700.1","27445338","USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation."
13727,13728d18482
< "P47857-1","RefSeq","NP_001156959.1","29655163","Insulin, the most known regulator of glucose consumption, specifically regulates the expression of PFKL and PFKM, which impact the regulation of glycolysis in the cell."
< "P47857-1","RefSeq","NP_001156959.1","27146165","This study demonstrated that the reveal PFK-1 as an important regulator of neurogenesis."
13736c18490,18492
< "Q3USJ8-1","RefSeq","NP_001139482.1","23437151","Our results suggest that FCHSD1 and FCHSD2 could modulate F-actin assembly or maintenance in hair cell stereocilia and cuticular plate."
---
> "Q9ERT2-1","RefSeq","NP_573465.1","23303050","TRH-R2 does not mediate the central nervous system effects of taltirelin, but TRH-R1 does."
> "Q9ERT2-1","RefSeq","NP_573465.1","22593547","We suggest that persistent signaling by TRHRs is exhibited when sufficient levels of agonist/receptor/G-protein complexes are established and maintained and that TRH-R2 forms and maintains these complexes more efficiently than TRH-R1."
> "Q9ERT2-1","RefSeq","NP_573465.1","19078951","Data provide the first evidence for the involvement of the TRH/TRH-R system, specifically extrahypothalamic TRH/TRH-R2, in regulating mood and affect"
13737a18494,18495
> "Q9WTU3-1","RefSeq","NP_035453.2","30601941","A severe gain-of-function mutation in Scn8a is dependent upon Cre recombinase in an animal model of encephalopathy."
> "Q9WTU3-1","RefSeq","NP_035453.2","29991598","In the absence of Nav1.6 expression, the AIS is occupied by Nav1.2 channels. However, APs are generated in the AIS, and differences in AP propagation to soma and dendrites are minimal."
13747a18506
> "Q99LE3-1","RefSeq","NP_084533.1","29496999","Mouse LysMD3 is a type II integral membrane protein that co-localizes with GM130+ structures, consistent with localization to the Golgi apparatus. LysMD3-deficient mice were born at Mendelian ratios and had no obvious pathological abnormalities. They also exhibited no obvious immune response deficiencies in a number of models of infection and inflammation.  LysMD3-deficient mice exhibited no signs of intestinal dysbiosis"
13762a18522,18523
> "Q9CS42-1","RefSeq","NP_080938.1","26004865","PRPS2 expression correlates with Sertoli-cell only syndrome and inhibits the apoptosis of TM4 Sertoli cells via the p53/Bcl-2/caspases signaling pathway."
> "Q9CS42-1","RefSeq","NP_080938.1","24855946","Study demonstrates with a Prps2 knockout mouse that the nexus between protein and nucleotide biosynthesis controlled by PRPS2 is crucial for Myc-driven tumorigenesis. Erratum:[Cell. 2014 Jul 31;158(3):689]"
13764,13766d18524
< "Q9Z0H0-1","RefSeq","NP_001258495.1","28887320","Increased Cdc7-dependent replication initiation is a hallmark of p53 gain-of function mutations in lung adenocarcinoma."
< "Q9Z0H0-1","RefSeq","NP_001258495.1","27401717","Results suggest a new role of Claspin in initiation of DNA replication during normal S phase through the recruitment of Cdc7 that facilitates phosphorylation of Mcm proteins. Publication Status: Online-Only"
< "Q9Z0H0-1","RefSeq","NP_001258495.1","24133205","Cdc7 physically and functionally interacts with Nkx2.5 to regulate Myocd promoter activity"
13784a18543
> "Q3TPJ7-1","RefSeq","NP_067540.1","24187134","Midnolin plays a role in cellular signaling of adult tissues and regulates glucokinase enzyme activity in pancreatic beta cells"
13801a18561
> "Q9QUN9-1","RefSeq","NP_056629.1","29980568","Dkk3 binds to CXCR7 and enhances vascular progenitor cells cell migration and vascular regeneration."
13803,13805d18562
< "Q3ULA2-1","RefSeq","NP_001032847.2","30391586","Investigated beta-TrCP function in Sertoli cells by generating mice with targeted deletion of the beta-TrCP2 gene in Sertoli cells on a background of whole-body beta-TrCP1 knockout. Loss of beta-TrCP in Sertoli cells caused infertility due to a reduction in the number of mature sperm."
< "Q3ULA2-1","RefSeq","NP_001032847.2","30619291","Study findings identify beta-TrCP as an important negative regulator for upstream signaling of IkappaBalpha in lipopolysaccharide pathway, and therefore renew the understanding of the roles of beta-TrCP in regulating toll-like receptors inflammatory signaling. Publication Status: Online-Only"
< "Q3ULA2-1","RefSeq","NP_001032847.2","30031111","Beta-TrCP was identified as a novel interacting partner of ASK1 that is capable of ubiquitinating and degrading ASK1 through the ubiquitin-proteasome system. These findings suggest that beta-TrCP is capable of suppressing oxidative stress-induced caspase 3-dependent apoptosis through suppression of ASK1."
13809a18567,18569
> "B2RQC2-1","RefSeq","NP_084025.2","16904385","Northern blot analysis revealed that Usp42 is expressed mainly in brain, lung, thymus and testis, and at E10.5 the most during embryonic development."
> "O35654-1","RefSeq","NP_032920.2","22824807","A direct interaction between Pold2 and PIAS2 was confirmed by direct yeast two-hybrid."
> "O35654-1","RefSeq","NP_032920.2","12522211","The association of PDIP38 with pol delta was shown to occur in calf thymus tissue and mammalian cell extracts by GST-PDIP38 pull-down and coimmunoprecipitation experiments."
13831a18592,18597
> "Q8BH10-1","RefSeq","NP_848866.2","29604961","Orai2 proteins contribute to Ca(2+) entry in connective tissue type mast cells in discrete operation modes depending on the availability of calcium ions in the extracellular space."
> "Q8BH10-1","RefSeq","NP_848866.2","28294127","ORAI1 and ORAI2 form heteromeric Ca(2+) release-activated Ca(2+) channels, in which ORAI2 fine-tunes the magnitude of Store-operated Ca(2+) entry to modulate immune responses. Publication Status: Online-Only"
> "Q8BH10-1","RefSeq","NP_848866.2","27881772","This study demonstrated that Transient Receptor Potential Canonical 6 (TRPC6) and Orai2 form stromal interaction molecule 2 (STIM2)-regulated neuronal-store-operated Ca(2+) influx (nSOC) channel complex in hippocampal synapse and the resulting Ca(2+) influx is critical for long-term maintenance of mushroom spines in hippocampal neurons."
> "Q8BH10-1","RefSeq","NP_848866.2","26956485","Results identified the ORAI-NOX2 feedback loop as a determinant of monocyte immune responses. Publication Status: Online-Only"
> "Q8BH10-1","RefSeq","NP_848866.2","25673771","The data from this study indicate that upregulation of STIM2 and Orai2 is involved in the phenotypic transition of pulmonary arterial smooth muscle cells from a contractile state to a proliferative state."
> "Q8BH10-1","RefSeq","NP_848866.2","23878235","Data indicate that the Ca(2+) release-activated Ca(2+) channels (CRAC) blocker GSK-7975A inhibited store-operated Ca(2+) entry in a concentration-dependent manner."
13834a18601,18604
> "Q9Z1X0-1","RefSeq","NP_035466.1","27930971","This study shows that losartan and dexamethasone may suppress inflammatory responses in IgA nephropathy by inhibiting CCL27 expression in Th22 cells"
> "Q9Z1X0-1","RefSeq","NP_035466.1","23321329","Our in vivo analysis demonstrated that uniform expression of Ccr10 on MSCs and alteration of Ccl27 level in the skin enhance extravasation of stem cells from circulation and facilitate their migration within cutaneous tissue"
> "Q9Z1X0-1","RefSeq","NP_035466.1","18025475","In mice, neutralization of CCL27 led to decreased leukocyte recruitment to cutaneous tumor sites and significantly enhanced primary tumor growth."
> "Q9Z1X0-1","RefSeq","NP_035466.1","16978841","LIGHT stimulation enhances CCL27 expression through activation of NF-kappaB in DCs."
13838c18608,18614
< "Q5DTU0-1","RefSeq","NP_001171268.1","27029000","We showed that XB130 might play protective roles in lipopolysaccharide-induced systemic septic response and acute lung injury"
---
> "Q8K341-1","RefSeq","NP_082752.3","30953095","ATAT1 found in regulating mouse forebrain development and governing tubulin hyperacetylation during stress responses, but also suggests the existence of an additional alpha-tubulin acetyltransferase."
> "Q8K341-1","RefSeq","NP_082752.3","29703898","TAK1 directly interacts with and phosphorylates alphaTAT1 at Ser237 to critically enhance its catalytic activity. Publication Status: Online-Only"
> "Q8K341-1","RefSeq","NP_082752.3","28687926","Atat1 knockdown resulted in a significant increase in the expression of ACTH-producing genes and decreased the dexamethasone-induced nuclear translocation of glucocorticoid receptor accompanied with a reduction in alpha-tubulin acetylation."
> "Q8K341-1","RefSeq","NP_082752.3","27976998","Here the authors demonstrate that mice lacking the alpha-tubulin acetyltransferase Atat1 in sensory neurons display profound deficits in their ability to detect mechanical stimuli. Publication Status: Online-Only"
> "Q8K341-1","RefSeq","NP_082752.3","23126280","Acetylation of alpha-tubulin is under the control of the acetyltransferase MEC-17 and deacetylases SIRT2 (Sirtuin 2) and HDAC6 (histone deacetylase 6). Adipocyte development is inhibited in MEC-17-knockdown cells, but enhanced in MEC-17-overexpressing cells."
> "Q920E5-1","RefSeq","NP_608219.1","29864496","Overexpression of FPPS aggravates myocardial ischemia/reperfusion injury in mice."
> "Q920E5-1","RefSeq","NP_608219.1","23180723","Farnesyl pyrophosphate synthase (FPPS) may function as a potent regulator in myocardial remodelling. The FPPS-regulated signalling pathway is relevant to the pathological changes in cardiac hypertrophy and heart failure."
13844a18621,18623
> "Q9Z139-1","RefSeq","NP_038873.2","30801848","Ror1 genetically interacts with Wnt9a. Ror1hyp/hyp;Wnt9a-/- double mutants displayed a secondary palate cleft phenotype and shorter long bones."
> "Q9Z139-1","RefSeq","NP_038873.2","30342492","ROR1 was one of the most significantly regulated receptor tyrosine kinases in the ischemic heart and may be a potential target for the treatment of ischemic heart injury. Publication Status: Online-Only"
> "Q6PDG5-1","RefSeq","NP_937803.1","27392482","These findings demonstrate involvement of BAF170-dependent chromatin remodeling in hippocampal neurogenesis."
13845a18625,18628
> "Q9R002-1","RefSeq","NP_036070.2","30104205","Enforced expression of IFI16-b inhibits the activation of AIM2 inflammasome, whereas knockdown of IFI16-b augments interleukin-1b secretion triggered by dsDNA but not dsRNA Thus, cytoplasm-localized IFI16-b is functionally equivalent to mouse p202 that exerts an inhibitory effect on AIM2 inflammasome. ."
> "Q9R002-1","RefSeq","NP_036070.2","30246031","The expression level of Ifi202b showed the most sex difference in correlation with known immune-related genes Publication Status: Online-Only"
> "Q9R002-1","RefSeq","NP_036070.2","29853536","P202 promotes osteogenesis in mouse bone marrow stromal cells. Publication Status: Online-Only"
> "Q9R002-1","RefSeq","NP_036070.2","29478099","Ifi202b and IFI16 have roles as obesity genes"
13846a18630,18635
> "Q6PR54-1","RefSeq","NP_780447.4","30022158","Data suggest that CST-Polalpha-mediated fill-in helps to control the repair of double-strand breaks by 53BP1, RIF1 and shieldin"
> "Q6PR54-1","RefSeq","NP_780447.4","29348174","Data support model in which Rif1 modulates chromatin loop structures through binding to multiple G-quadruplex assemblies and by holding chromatin fibers together."
> "Q6PR54-1","RefSeq","NP_780447.4","29719287","Knockdown of RIF1 increases cisplatin sensitivity in vivo in Epithelial Ovarian Cancer."
> "Q6PR54-1","RefSeq","NP_780447.4","15042697","This is a mouse ortholog of the yeast Rif1 family of telomere-associated proteins identified on the basis of its high expression in primordial germ cells and embryo-derived pluripotent stem cell lines."
> "Q9D513-1","RefSeq","NP_083473.1","28453612","We find that MEIOB and SPATA22 form an obligate complex and contain defined interaction domains GeneRIF: MEIOB and SPATA22 form an obligate complex and contain defined interaction domains.  A single residue D383 in MEIOB is indispensable for the MEIOB-SPATA22 interaction.  The MEIOB/SPATA22 complex interacts with the RPA heterotrimeric complex in a collaborative manner."
> "Q9D513-1","RefSeq","NP_083473.1","24240703","MEIOB is required for meiotic recombination and chromosomal synapsis. GeneRIF: MEIOB is a meiosis-specific paralogue of RPA1.  MEIOB colocalizes with RPA in foci on meiotic chromosomes.  MEIOB binds to single-stranded DNA and exhibits 3'-5' exonuclease activity. MEIOB forms a complex with RPA and with SPATA22.  Chromatin localization and stability of MEIOB depends on SPATA22 and vice versa.  MEIOB is essential for meiotic recombination in both sexes."
13853a18643,18644
> "Q9JLI2-1","RefSeq","NP_058615.1","22214369","Present study examined the expression of pro-alpha3(V) collagen gene in a mouse model of wound healing."
> "Q9JLI2-1","RefSeq","NP_058615.1","15136578","Analysis of processing of the Pro-alpha1(V)Pro-alpha2(V)Pro-alpha3(V) procollagen heterotrimer"
13862a18654
> "Q61792-1","RefSeq","NP_034818.1","25385028","Results defined LASP1 as a direct target gene for HIF1alpha upregulation that is critical for metastatic progression of PDAC."
13863a18656
> "Q9WVJ5-1","RefSeq","NP_076184.1","30646012","The current study shows for the first time that two highly expressed lens crystallin genes, Cryba4 and Crybb1, can be simultaneously transcribed from adjacent bidirectional promoters and do not show nuclear accumulation."
13877a18671,18672
> "Q8CI08-1","RefSeq","NP_705795.2","23077057","SLAIN2 is expressed throughout development and is highly enriched in brain."
> "Q8CI08-1","RefSeq","NP_705795.2","21646404","Results identify SLAIN2 as a key component of microtubule plus end interaction networks."
13896a18692,18697
> "Q8C863-1","RefSeq","NP_032421.2","29925997","Itch and WWP2 cooperate to regulate TH2 differentiation by enhancing the strength of the TCR signal via inducing atypical ubiquitination of the phosphatase SHP-1."
> "Q8C863-1","RefSeq","NP_032421.2","29515120","Beta-Arrestin2 increases the Itch-mediated ubiquitylation of SuFu. Publication Status: Online-Only"
> "Q8C863-1","RefSeq","NP_032421.2","28747490","Findings show that the WW domains proceeding the catalytic HECT domain play an inhibitory role by binding directly to HECT in Itch; study provides a new mechanism governing the regulation of Itch"
> "P33622-1","RefSeq","NP_075603.1","30223835","Both triglyceride-rich lipoproteins (TRLs) and ApoCIII contribute to the progression of atherosclerosis, and the modulation of TRLs and ApoCIII may represent a novel therapeutic approach against hypertriglyceridemia induced atherosclerosis. Publication Status: Online-Only"
> "P33622-1","RefSeq","NP_075603.1","28887372","C3(QK) variant is a gain-of-function mutation that can stimulate VLDL1 production, through enhanced DNL"
> "P33622-1","RefSeq","NP_075603.1","28739253","These data strongly suggest that intestinal apoC-III is not a FoxO1 target and support the idea that apoC-III is not regulated coordinately with hepatic apoC-III, and establishes another key aspect of apoC-III that is unique in the intestine from the liver."
13910a18712,18715
> "Q9ERL9-1","RefSeq","NP_068696.2","28465505","Study shows notch signaling provides a constitutive drive on expression of the major nitric oxide receptor GUCY1A3 and GUCY1B3 in arteries from mice. Publication Status: Online-Only"
> "Q3UDK1-1","RefSeq","NP_758479.2","25992615","TRAFD1, in association with Plekhm1/Rab7-positive late endosomes-early lysosomes, has a previously unknown role in vesicle trafficking, acidification, and resorption in osteoclasts Publication Status: Online-Only"
> "Q3UDK1-1","RefSeq","NP_758479.2","18849341","FLN29, in addition to playing a negative regulatory role in the TLR4 signaling pathway, negatively regulates the RIG-I-like helicase signaling pathway at the level of IPS-1/TRAF6 and IPS-1/TRAF3 complexes"
> "Q3UDK1-1","RefSeq","NP_758479.2","16221674","FLN29 is a new negative feedback regulator of TLR signaling"
13920a18726
> "A0A0B4J1F4-1","RefSeq","NP_079825.2","19605364","Txnip regulates cellular metabolism independent of its binding to thioredoxin and the arrestin domains are crucial structural elements in metabolic functions of alpha-arrestin proteins"
13923a18730,18736
> "P97372-1","RefSeq","NP_035320.1","30400847","Overexpression of PA28alpha and concomitant upregulation of PA28beta protein reduces depressive-like behavior and enhances learning and memory in female mice. The overexpression of PA28alpha does not increase PA28alphabeta-dependent proteasome activity but could still be linked to its protective functions upon oxidative stress and proteinopathy. Publication Status: Online-Only"
> "P97372-1","RefSeq","NP_035320.1","28867616","Study clarifies the subunit composition and arrangement of PA28ab and provides key insights into the assembly of an asymmetric complex from two highly homologous subunits. Differential scanning fluorimetry experiments and activity assays classify PA28alpha4beta3 as most stable and most active, indicating that this assembly might represent the physiologically relevant species."
> "P97372-1","RefSeq","NP_035320.1","28278207","Increased PA28B expression is associated with viral myocarditis. Publication Status: Online-Only"
> "O54962-1","RefSeq","NP_035923.1","24945635","BAF can act in a phosphorylation-regulated manner to impair HSV-1 transcription and/or DNA replication. Publication Status: Online-Only"
> "O54962-1","RefSeq","NP_035923.1","21750191","Data determined that the knockdown of Banf1 alters the cell cycle distribution of both human and mouse ESCs by causing an uncharacteristic increase in the proportion of cells in the G2-M phase of the cell cycle."
> "O54962-1","RefSeq","NP_035923.1","19567673","Results suggest that Bcrp1 and P-gp transport topotecan into vCSF and out of brain parenchyma through the blood-brain barrier, and findings may help to improve pharmacologic strategies to treat brain tumors."
> "O54962-1","RefSeq","NP_035923.1","14523012","HB and barrier-to-autointegration factor are the same protein"
13926a18740,18744
> "Q61171-1","RefSeq","NP_035693.3","29778464","Deletion of Prdx2 increases age-related ovarian failure."
> "Q61171-1","RefSeq","NP_035693.3","29720484","CDK2 depletion led to the reactivation of differentiation pathway translation, and the differentiation blockade function of CDK2 may be achieved directly by maintaining the activity of PRDX2. CDK2 depletion arrested tumor growth of acute myeloid leukemia (AML) cells in nude mice."
> "Q61171-1","RefSeq","NP_035693.3","29503398","Data suggests that Prdx1 and Prdx2 in pronuclei of zygotes are involved in antioxidant mechanisms and epigenetic programming during maternal-to-zygotic transition (during ectogenesis following in vitro fertilization). PRDX1 and PRDX2 appear to be ninth and twenty-second highest expressed proteins, respectively, among 64 proteins identified in mouse zygotes."
> "Q61171-1","RefSeq","NP_035693.3","28793778","Our data highlight a novel role of Prx2 in iron homeostasis. Prx2 is a key cytoprotector against IO that is induced either by iron supplementation or due to chronic hemolysis as in beta-thalassemia."
> "Q61171-1","RefSeq","NP_035693.3","28801243","The data indicate that Prx2 is able to interrupt the hypoxia induced vicious cycle involving oxidation-inflammation-autophagy in the pathogenesis of pulmonary hypertension."
13929,13933d18746
< "A2A8U2-1","RefSeq","NP_001271199.1","28893537","These observations suggest that tumor suppression was caused not by mtDNA with polymorphic mutations or infection of cytozoic bacteria but by hypothetical heritable cytoplasmic elements other than mtDNA from SAMP1 mice."
< "A2A8U2-1","RefSeq","NP_001271199.1","28301579","Data demonstrate a heightened susceptibility to colonic inflammation and tumorigenesis in AOM/DSS-treated SAMP mice with CD-like ileitis Publication Status: Online-Only"
< "A2A8U2-1","RefSeq","NP_001271199.1","25051721","In the SAMP1 mice versus the SAMR1 ones, the glial index rose by 36% in layer III and by 24% in layer V. During simulation of physiological aging, the sizes of neuronal bodies were shown to be virtually unchanged in the cerebral cortex"
< "A2A8U2-1","RefSeq","NP_001271199.1","23583482","At 2- and 4-months old, SAMP1 mice show motor-coordination dysfunction."
< "A2A8U2-1","RefSeq","NP_001271199.1","22349700","Findings show that the nuclear envelope protein Samp1 is involved in nuclear movement during fibroblast polarization and migration GeneRIF: Nuclear envelope protein Samp1 (NET5) is involved in nuclear movement during fibroblast polarization and migration. Samp1 is part of the TAN lines complex that contain nesprin-2G and SUN2. Samp1 associates with SUN2 and lamin A/C."
13935a18749,18751
> "P31725-1","RefSeq","NP_033140.1","30906792","This study shows that neutrophil-derived MRP14 supports plasma cell commitment and protects myeloma cells from apoptosis Publication Status: Online-Only"
> "P31725-1","RefSeq","NP_033140.1","30586702","Increased VEGF165b expression in macrophages induces an antiangiogenic M1-like phenotype that directly impairs angiogenesis. VEGFR1 inhibition by VEGF165b results in S100A8/S100A9-mediated calcium influx to induce an M1-like phenotype that impairs ischemic muscle revascularization and perfusion recovery."
> "P31725-1","RefSeq","NP_033140.1","30056999","This study shows that MRP14 does not contribute to dissemination or inflammation in a murine model of Lyme borreliosis"
13943a18760
> "P21803-1","RefSeq","NP_963895.2","30756235","The role of the FGFR2b signaling in the odontoblast differentiation and dentin formation."
13944a18762,18765
> "Q8C196-1","RefSeq","NP_001074278.1","29801986","To investigate the efficacy of gene therapy for CPS deficiency following knock-down of hepatic endogenous CPS1 expression, we injected these mice with a helper-dependent adenoviral vector (HDAd) expressing the large murine CPS1 cDNA under control of the phosphoenolpyruvate carboxykinase promoter"
> "Q8C196-1","RefSeq","NP_001074278.1","20097174","Because ammonia generated during fasting is toxic, SIRT5 protein might play a protective role by converting ammonia to non-toxic urea through deacetylation and activation of CPS1."
> "Q8C196-1","RefSeq","NP_001074278.1","19410549","SIRT5 deacetylates CPS1 and upregulates its activity"
> "E9Q5M6-1","RefSeq","NP_001028419.1","28552195","Biallelic mutations in either CFAP43 or CFAP44 can cause sperm flagellar abnormalities and impair sperm motility."
13946,13951d18766
< "Q91WP0-1","RefSeq","NP_001003893.1","28739878","This study shows that MASP-2 contributes to the development of collagen Ab-induced arthritis"
< "Q91WP0-1","RefSeq","NP_001003893.1","28462915","It has been shown that key proteins in the lectin arm of this pathway, MASP1, MASP2 and C3, are expressed in the developing cortex and that neuronal migration is impaired in knockout and knockdown mice. Publication Status: Online-Only"
< "Q91WP0-1","RefSeq","NP_001003893.1","27235854","We induced anti-myeloperoxidase vasculitis in mice and showed that neither MASP-2- nor properdin-deficient mice were protected, suggesting that alternative pathway activation does not require properdin or the lectin pathway."
< "Q91WP0-1","RefSeq","NP_001003893.1","27577570","MASP-2 has an essential role in the mediation of cerebral ischemia-reperfusion injury. Publication Status: Online-Only"
< "Q91WP0-1","RefSeq","NP_001003893.1","15826378","Recombinant protein of masp2 was made and purified."
< "Q91WP0-1","RefSeq","NP_001003893.1","15672593","Highly conserved intron sequences. Restricted expression contrasts with the ubiquitous expression of neighboring genes."
13954a18770,18775
> "Q60631-1","RefSeq","NP_032189.1","30183074","GRB2 inhibitors may have the potential to dampen tissue eosinophilia in various eosinophil-associated diseases."
> "Q60631-1","RefSeq","NP_032189.1","28964849","Our findings position Grb2 as a key adaptor that integrates various cytokines response in cycling Hematopoietic Stem and Progenitor Cell ."
> "Q60631-1","RefSeq","NP_032189.1","28455498","Study shows that growth factor receptor binding protein 2 carboxyl-terminal SH3 domain can bivalently associate with two ligands, in an SH3 dependent manner. Extrapolating the results of this study to the in vivo conditions, Grb2 should bind the SLP65 transducer module first, and then Vav should associate. Publication Status: Online-Only"
> "Q9D6H2-1","RefSeq","NP_082670.1","29626631","This work indicates that IFT25 and IFT27 are important players in the early development of the kidney and suggest that duplex kidney is part of the ciliopathy spectrum."
> "Q9D6H2-1","RefSeq","NP_082670.1","28964737","FFndings suggest that like IFT25, IFT27, even though not required for ciliogenesis in somatic cells, is essential for sperm flagella formation, sperm function, and male fertility in mice. IFT25 and IFT27 control sperm formation/function through many common mechanisms, but IFT25 has additional roles beyond IFT27."
> "Q9D6H2-1","RefSeq","NP_082670.1","22595669","IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport."
13980a18802,18803
> "Q8CHT1-1","RefSeq","NP_063920.2","29363583","We found ephexin1 essential for the development of limb nerves toward their muscle targets, concluding that it functions as an intermediary to relay Eph signaling in this context"
> "Q8CHT1-1","RefSeq","NP_063920.2","28769056","These findings suggest that increased EphA4-ephexin1 signaling in the PFC plays a role in the pathophysiology of depression. Publication Status: Online-Only"
13985a18809,18812
> "P47739-1","RefSeq","NP_031462.2","30429219","This study found that oncogene-transformed embryonic fibroblasts prepared from Per2-mutant (Per2(m/m) ) mice, which are susceptible to both spontaneous and radiation-induced tumorigenesis, were resistant against common chemotherapeutic drugs and that this resistance is associated with up-regulation of the aldehyde dehydrogenase 3a1 (Aldh3a1) gene."
> "P47739-1","RefSeq","NP_031462.2","29663519","It is responsible for systemic alcohol metabolism."
> "P47739-1","RefSeq","NP_031462.2","29794221","ALDH3A1 activation by d-limonene significantly reduced aldehyde accumulation in SSPCs."
> "P47739-1","RefSeq","NP_031462.2","30568058","The alcohol dehydrogenase 3 (ADH3-/-) control mice exhibited increased activities of both osteoblasts and osteoclasts and lower bone masses than the WT control mice."
13988a18816
> "Q5SUQ9-1","RefSeq","NP_001268394.1","22531781","These data demonstrate an essential role for CTC1 in promoting efficient replication and length maintenance of telomeres."
14009,14013c18837,18842
< "Q91ZS8-1","RefSeq","NP_001020008.1","29694894","PKCzeta/ADAR2 axis is a critical regulator of colorectal cancer metastases through modulation of miR-200 levels."
< "Q91ZS8-1","RefSeq","NP_001020008.1","28640668","FMRP inhibits ADAR2 activity, absence of FMRP results in defects of RNA editing of neuronal mRNAs in the mouse model of Fragile X Syndrome."
< "Q91ZS8-1","RefSeq","NP_001020008.1","28395340","ADARB1 mediates adenosine to inosine RNA editing in the testis, and these editing events are dispensable for male fertility in an inbred mouse strain in the lab."
< "Q91ZS8-1","RefSeq","NP_001020008.1","16382140","ADAR2 autoediting is a key regulator of ADAR2 protein expression and activity in vivo."
< "Q8C6B2-1","RefSeq","NP_001129699.1","22503686","These findings suggest that cGK-Ialpha interacts with and phosphorylates rhotekin, thereby contributing to neurite outgrowth regulation."
---
> "P51680-1","RefSeq","NP_034046.2","30337650","Malaria-associated acute respiratory distress syndrome was dependent on functional CCR4, known to mediate the recruitment of Th2 lymphocytes and regulatory T cells."
> "P51680-1","RefSeq","NP_034046.2","30183073","The use of a small molecule CCR4 antagonist to prevent Tregs induction."
> "P51680-1","RefSeq","NP_034046.2","29510192","Using atopic dermatitis model in BALB/c mice, study demonstrated that Ccr4-deficiency or a Ccr4 antagonist ameliorated the allergic responses. Collectively, these results demonstrate that Ccr4 plays a pivotal role in skin allergic inflammation of BALB/c mice by recruiting Ccr4-expressing Th2 cells and Th17 cells."
> "Q9Z2W8-1","RefSeq","NP_062665.3","28856535","Find that during the first week in culture (DIV2-6) when GluA4 expression is restricted to pyramidal neurons, loss of GluA4 has no effect on the overall excitability of the immature network"
> "Q9Z2W8-1","RefSeq","NP_062665.3","30692144","Frrsl1 deletion results in an increased proportion of immature AMPA receptors, indicated by incomplete glycosylation of GLUA2 (also known as GRIA2) and GLUA4 (also known as GRIA4) AMPA receptor proteins. Publication Status: Online-Only"
> "Q9Z2W8-1","RefSeq","NP_062665.3","29704264","Study indentifies NF-Yb as a novel transcriptional regulator of Gria4 (GluA4 gene), and a controller of excitotoxic death in the oligodendroglial lineage; describes a novel regulatory region within Gria4 containing CCAAT sequences whose binding by NF-Yb is regulated by excitotoxicity. Excitotoxicity-induced alterations in NF-Yb binding are associated with changes in Gria4 transcription."
14017a18847
> "O35218-1","RefSeq","NP_058552.1","22838834","Cpsf2,Ppil2, and SNAP-25 are the most promising targets for the NSm protein of the virus during an infection. Publication Status: Online-Only"
14019a18850,18861
> "P28825-1","RefSeq","NP_032611.2","30235485","This study shows that docking of meprin alpha to heparan sulphate protects the endothelium from inflammatory cell extravasation"
> "P28825-1","RefSeq","NP_032611.2","27628095","No significant dentin malformation was observed in Mep1b (-/-) or Mep1a (-/-) deficient mice."
> "P28825-1","RefSeq","NP_032611.2","26491063","Meprin alpha and meprin beta join the modulators of Reelin signalling as they cleave Reelin at a specific site and are upregulated under specific pathological conditions."
> "P28825-1","RefSeq","NP_032611.2","25354939","While meprin A only cleaved protein kinase A (PKA) catalytic subunit beta1, meprin B cleaved all three PKA catalytic isoforms."
> "Q8BZ89-1","RefSeq","NP_766174.1","24550733","Our results demonstrate that Zfp322a is a novel essential component of the transcription factor network which maintains the identity of mouse ES cells. Publication Status: Online-Only"
> "Q80WQ6-1","RefSeq","NP_766160.2","30165303","These findings indicated that iRhom2 played an essential role in regulating particulate matter (PM2.5) -induced chronic renal damage, thus revealing a potential target for preventing chronic kidney diseases development."
> "Q80WQ6-1","RefSeq","NP_766160.2","30097271","The iRhom2 played a key role in the pathogenesis of atherosclerosis, and that iRhom2 might be a potential therapeutic target against atherosclerosis."
> "Q80WQ6-1","RefSeq","NP_766160.2","29897336","FRMD8 promotes inflammatory and growth factor signaling by stabilizing the iRhom2/ADAM17 sheddase complex. Publication Status: Online-Only"
> "Q80WQ6-1","RefSeq","NP_766160.2","29897333","ITAP (FRMD8) is a novel iRhom2 interactor that controls TNF-alpha secretion by policing the stability of iRhom2/ADAM17 complex. Publication Status: Online-Only"
> "Q80WQ6-1","RefSeq","NP_766160.2","29523849","IRHOM2 is a novel target gene of p63 and that both p63 and iRHOM2 differentially regulate cellular stress-associated signalling pathways in normal and hyperproliferative keratinocytes. Publication Status: Online-Only"
> "Q80WQ6-1","RefSeq","NP_766160.2","22246778","Study reports iRhom2 interacted with TACE and regulated TNFalpha shedding; iRhom2 was critical for TACE maturation and trafficking to cell surface in hematopoietic cells; study identified iRhom2 as a regulator of innate immunity"
> "Q80WQ6-1","RefSeq","NP_766160.2","22246777","IRhom2 is required for TNF release; iRhom2 binds TACE and promotes its exit from the ER; failure of TACE to exit the ER in the absence of iRhom2 prevents the furin-mediated maturation and trafficking of TACE to the cell surface, the site of TNF cleavage"
14023a18866,18884
> "A2ALU4-1","RefSeq","NP_766029.2","21248203","Data suggest that Shroom2 facilitates the formation of a contractile network within endothelial cells, the loss of which leads to an increase in endothelial sprouting, migration, and angiogenesis."
> "A2ALU4-1","RefSeq","NP_766029.2","17666436","Shroom2 and ZO-1 form a tight-junction-associated scaffolding complex, possibly linked to myosin VIIa, that bridges the junctional membrane to the underlying cytoskeleton, thereby contributing to the stabilization of these junctions."
> "Q8BND5-1","RefSeq","NP_075757.1","29800099","Our study provides the first comprehensive comparisons between QSOX1 and QSOX2 in the mouse epididymis, revealing their distinct epididymal distribution, cellular localization, mechanisms of secretion and sperm membrane association"
> "Q8BND5-1","RefSeq","NP_075757.1","29723491","The data indicated that QSOX1 is required 1) for a proper protein folding in the endo/sarcoplasmic reticulum (ER/SR) and 2) for resolution and protective response during acute stress."
> "Q8BND5-1","RefSeq","NP_075757.1","27581528","Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms, in particular, by the serum QSOX1."
> "Q8BND5-1","RefSeq","NP_075757.1","24475161","QSOX1 inhibits autophagy in breast cancer cells. Publication Status: Online-Only"
> "Q8BND5-1","RefSeq","NP_075757.1","16160860","In seminiferous tubules, where a high level of expression was noticed, QSOX might play an important physiological role in sperm function and serve as a marker for the diagnosis of male infertility."
> "Q8BND5-1","RefSeq","NP_075757.1","12354420","Cloned skin SOx cDNA and characterized it as one of the disulfide (S-S) cross-linking enzymes"
> "Q9D3G9-1","RefSeq","NP_001074574.1","27740624","These results highlight a novel negative regulatory role for RhoH in eosinophil differentiation, most likely in consequence of altered GATA-2 levels."
> "Q9D3G9-1","RefSeq","NP_001074574.1","26114424","An excess amount of RhoH is able to initiate pre-TCR signaling in the absence of pre-TCR complexes. Publication Status: Online-Only"
> "Q9D3G9-1","RefSeq","NP_001074574.1","24189071","The C-terminal insert domain regulates RhoH protein stability via chaperone-mediated autophagy."
> "Q9D3G9-1","RefSeq","NP_001074574.1","18089848","An antagonistic role of RhoH in regulation of cortical F-actin assembly and chemotaxis via suppressing Rac1 membrane targeting and activation in primary hematopoietic progenitor cells, is identified."
> "Q9D3G9-1","RefSeq","NP_001074574.1","17119112","RhoH is important for pre-T-cell receptor and T-cell receptor signaling"
> "Q9D3G9-1","RefSeq","NP_001074574.1","17028588","RhoH is a critical regulator of thymocyte development and TCR signaling by mediating recruitment and activation of Zap70."
> "Q9D3G9-1","RefSeq","NP_001074574.1","15494435","RhoH serves as a negative regulator of both growth and actin-based function of hematopoietic progenitor cells possibly via suppression of Rac-mediated signaling."
> "Q9D5T7-1","RefSeq","NP_080765.1","29414051","Exogenous DSBs recruit the meiosis-specific homologous recombination repair machinery, are translocated to the axial elements, contribute to homology recognition, and that their repair is modulated by HORMAD1."
> "Q9D5T7-1","RefSeq","NP_080765.1","19686734","Results suggest that also mammalian cells use a HORMA domain-containing protein (HORMAD1) as part of a surveillance system that monitors chromosomal synapsis or other interactions between homologs."
> "Q9D5T7-1","RefSeq","NP_080765.1","19851446","HORMAD1 and HORMAD2 are depleted from synapsed chromosome axes with the help of TRIP13."
> "Q9D5T7-1","RefSeq","NP_080765.1","15567723","The expression pattern of Nohma suggests that it may be a critical regulatory protein in germ cell meiosis."
14034,14035c18895,18899
< "Q9QYR6-1","RefSeq","NP_001166977.1","28701415","Structure of the PSD-95/MAP1A complex reveals a unique target recognition mode of the MAGUK GK domain. Publication Status: Online-Only"
< "Q9QYR6-1","RefSeq","NP_001166977.1","26609151","Mutant mice lacking MAP1A exhibited reduced synaptic plasticity."
---
> "Q6P253-1","RefSeq","NP_766487.3","24794495","Authors improved the knowledge of Dmkn expression in mouse and highlighted a role for Dmkn beta and gamma in cornification."
> "Q6P253-1","RefSeq","NP_766487.3","23428944","These results suggest that dermokine-beta delays early cutaneous wound healing in part by inhibiting expression of CXC chemokines containing the ERL-sequence motif."
> "Q6P253-1","RefSeq","NP_766487.3","17380110","Dermokine gene is expressed in epithelial tissues other than the skin and this expression is transcriptionally and posttranscriptionally complex."
> "Q6P253-1","RefSeq","NP_766487.3","17330888","Drmkn and Krtdap are the highest differentially expressed genes in epidermis embryonic development in mice."
> "Q6P253-1","RefSeq","NP_766487.3","15234001","Identification of a novel gene (dermokine)giving rise to two splicing variants, both of which are expressed in the spinous layer of epidermis"
14047c18911,18914
< "P63013-1","RefSeq","NP_035257.1","28366454","Postnatal PRX1-expressing stem cells of the calvaria are required for bone regeneration."
---
> "P08882-1","RefSeq","NP_034501.2","19414782","Granzyme C is activated with persistent antigenic stimulation, providing nonredundant backup protection for the host when granzyme B fails."
> "O88708-1","RefSeq","NP_036088.3","28230328","Together, these data demonstrate that ORC4 oligomerization is required to form the ORC4 cage and that it is required for polar body extrusion."
> "O88708-1","RefSeq","NP_036088.3","25502171","ORC4 surrounds the chromatin that will be extruded in the polar body in both female meiotic divisions, then makes a transition from the cytoplasm to the chromosomes at zygotic anaphase, suggesting multiple roles for this replication licensing protein."
> "Q80U40-1","RefSeq","NP_001297662.1","17855024","Rimbp2 is identified in mouse."
14070a18938,18942
> "Q9CW07-1","RefSeq","NP_083904.1","27815211","PPP1R3G is an important player that links glycogen metabolism to lipid metabolism in vivo."
> "Q9CW07-1","RefSeq","NP_083904.1","24264575","PPP1R3G plays a critical role in postprandial glucose homeostasis and liver triglyceride metabolism via its regulation on hepatic glycogenesis."
> "Q9CW07-1","RefSeq","NP_083904.1","21471512","PPP1R3G plays a major role to control postprandial glucose homeostasis during the fasting-feeding transition via its regulation on liver glycogenesis."
> "Q9DBC7-1","RefSeq","NP_068680.1","29289659","Mice with a genetic background of Tpo-Cre;Prkar1a(flox/flox);Epac1(-/-) are aggressive, and both the thyroid-specific knockout of Prkar1a and global knockout of Epac1 likely contribute to this aggressive behavior. This study supports the hypothesis that altered thyroid signaling and aggressive behavior are linked."
> "Q9DBC7-1","RefSeq","NP_068680.1","28615245","Kidney-specific loss of Prkar1a induced renal cystic disease and markedly aggravated cystogenesis in the Pkd1(RC) models."
14073a18946
> "Q8CIV3-1","RefSeq","NP_700453.1","23677168","We finally isolate control and Enpp2-null dermal pipilla precursors and identify the expression and upregulation of LIPH, an alternative LPA-producing enzyme, suggesting that this gene could functionally compensate for the absence of Enpp2."
14086a18960,18968
> "Q8VE01-1","RefSeq","NP_776106.1","18385140","Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane"
> "P97820-1","RefSeq","NP_032722.2","30200638","Study identified a novel splicing network composed of RBM4a, SRSF3, and MAP4K4 in brown adipogenesis and subsequently manipulating the effect of downstream JNK signaling which contributes to insulin resistance and reduced metabolism. Publication Status: Online-Only"
> "P97820-1","RefSeq","NP_032722.2","28611026","Blood endothelial Map4k4 promotes vascular dysfunction and impairs glucose homeostasis in adult animals, lymphatic endothelial Map4k4 is required to maintain lymphatic vascular integrity and regulate immune cell trafficking in obesity."
> "P97820-1","RefSeq","NP_032722.2","28771231","The close proximity between AcSDKP and FGFR1 was essential for the suppression of TGFbeta/smad signaling and EndMT associated with MAP4K4 phosphorylation (P-MAP4K4) in endothelial cells. Publication Status: Online-Only"
> "P97820-1","RefSeq","NP_032722.2","27226575","These results demonstrate that protein kinase Map4k4 drives obesity-induced hyperinsulinemia and insulin resistance in part by promoting insulin secretion from beta cells in mice."
> "Q6I6G8-1","RefSeq","NP_766243.2","29260931","That circHECW2 regulated the EndoMT by directly binding to MIR30D, a significantly downregulated miRNA from miRNA profiling, which subsequently caused an increased expression of ATG5"
> "Q6I6G8-1","RefSeq","NP_766243.2","27119228","Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity."
> "Q6I6G8-1","RefSeq","NP_766243.2","25555806","NEDL2 positively regulates enteric neural precursor proliferation through the GDNF/Akt signaling pathway."
> "Q6I6G8-1","RefSeq","NP_766243.2","15284439","Grk2 phosphorylates the C terminus of the Na-channel beta subunit and renders the channels insensitive to inhibition by Nedd4-2"
14087a18970,18971
> "P81269-1","RefSeq","NP_031523.3","25312646","The HSF1 complex, including BRG1 and lysine acetyltransferases p300 and CREB-binding protein (CBP), is formed in a manner dependent on the phosphorylation of ATF1"
> "P81269-1","RefSeq","NP_031523.3","24719331","Conclude that HO-1 regulates DC maturation and function by modulating the p38 MAPK-CREB/ATF1 signaling axis"
14088a18973,18975
> "Q80XB4-1","RefSeq","NP_932307.2","21998026","Nrarp-deficient embryos and mice exhibit genetic background-dependent defects of the axial skeleton. In Nrarp mutant embryos, the posterior somite compartment was expanded."
> "Q80XB4-1","RefSeq","NP_932307.2","21276443","Results show that chronic NRAP overexpression in the mouse leads to right ventricular cardiomyopathy by 10 months of age."
> "Q80XB4-1","RefSeq","NP_932307.2","12789664","Highly conserved and exclusively expressed in cardiac and skeletal muscle.  Candidate cause for cardiac and skeletal myopathies"
14123a19011,19012
> "Q922G7-1","RefSeq","NP_036032.2","18474621","Tek2-dependent organization of the central spindle during anaphase is essential for proper midbody formation and the segregation of daughter cells after cytokinesis."
> "Q922G7-1","RefSeq","NP_036032.2","15340058","Tektin-t participates in dynein inner arm formation or attachment and that the loss of Tektin-t results in impaired motility of both flagella and cilia."
14142,14144d19030
< "Q6P9K9-1","RefSeq","NP_001185516.2","29681532","Mice of the 129 strain carry a unique missense variant in neurexin 3 and exhibit a profound and selective enhancement in observational fear."
< "Q6P9K9-1","RefSeq","NP_001185516.2","9856994","N-terminal sequencing of rat neurexin III alpha provides evidence for signal peptide"
< "Q6P9K9-1","RefSeq","NP_001185516.2","8163501","N-terminal sequencing of cow neurexin III beta provides evidence for signal peptide"
14149a19036,19039
> "Q9EPS3-1","RefSeq","NP_201577.3","26116392","Results found that loss of Glce leads to a delayed onset of hypertrophic differentiation combined with an expanded region of proliferating chondrocytes indicating increased Ihh signaling."
> "Q9EPS3-1","RefSeq","NP_201577.3","20118238","Analysis of the activity of heparan sulfate C5-epimerase and its mutants by using engineered 2-O-sulfotransferase"
> "Q9EPS3-1","RefSeq","NP_201577.3","20208005","Modification of heparan sulfate by glucuronyl C5-epimerase is required for controlling the activity of molecules that are instructive for early lymphoid tissue morphogenesis"
> "Q9EPS3-1","RefSeq","NP_201577.3","15292174","NDST-1 and C5-epimerase have roles in heparan sulfate structure alterations in mouse tissue"
14184a19075,19076
> "Q5SQX6-1","RefSeq","NP_598530.2","28692454","Study characterized the functional roles of the two brain-specific phosphorylation sites (S582 and T1067) of CYFIP2 in cultured hippocampal neurons; found that overexpression of the phospho-blocking T1067A mutant significantly decreased the density of stubby spines, but not other types of spines. Study found that T1067 phosphorylation of CYFIP2 could potentially weaken the interaction between CYFIP2 and Nap1."
> "Q5SQX6-1","RefSeq","NP_598530.2","27914629","Study identified cytoplasmic FMR1-Interacting Protein 2 (Cyfip2) as a major significant genetic factor underlying binge eating and provide a behavioral paradigm for future genome-wide association studies in populations with increased genetic complexity."
14191,14195c19083,19096
< "Q8VCS0-1","RefSeq","NP_001258405.1","28951252","Study shows sex-dependent alterations in motor and anxiety-like behavior of aged bacterial peptidoglycan sensing molecule 2 (Pglyrp2) knockout mice. The findings suggest a novel role for Pglyrp2 as a key regulator of motor and anxiety-like behavior in late life."
< "Q8VCS0-1","RefSeq","NP_001258405.1","26332373","Pglyrp-2 expression was induced after infection in WT mice. Pglyrp-3 expression was low before and after infection in WT mice, while Pglyrp-4 expression was slightly elevated after infection in WT, Pglyrp-2 and -3 null mice Publication Status: Online-Only"
< "Q8VCS0-1","RefSeq","NP_001258405.1","22615249","Nod2(-/-) Pglyrp2(-/-) mice displayed increased susceptibility to infection at 24 h postinfection compared to Pglyrp2(-/-). Thus, PGLYRP2 plays a protective role in vivo in the control of S. Typhimurium infection through a Nod1/Nod2-independent mechanism."
< "Q8VCS0-1","RefSeq","NP_001258405.1","22048773","Pglyrp2 limits overactivation of Th17 cells by promoting accumulation of regulatory T cells at the site of inflammation in an experimentally induced mouse model of psoriasis"
< "Q8VCS0-1","RefSeq","NP_001258405.1","15340057","In contrast to its critical role in immunity in flies, PGRP-L is largely dispensable for mammalian immunity against bacteria and fungi."
---
> "Q9EST8-1","RefSeq","NP_085115.1","30224457","Results uncover an important role for IkappaBzeta in IL-36 signaling and validate IkappaBzeta as an attractive target for psoriasis therapy."
> "Q9EST8-1","RefSeq","NP_085115.1","29934320","PDLIM2, known as the ubiquitin E3 ligase, participates in NQO1-dependent IkappaB-zeta degradation."
> "Q9EST8-1","RefSeq","NP_085115.1","29670287","Electrophilic properties of itaconate and derivatives regulate the IkappaBzeta-ATF3 inflammatory axis; results demonstrate that targeting the DI-IkappaBzeta regulatory axis could be an important new strategy for the treatment of IL-17-IkappaBzeta-mediated autoimmune diseases"
> "Q9EST8-1","RefSeq","NP_085115.1","28740238","Results suggest that the Nfkbiz gene has a potential regulatory role in the microbiota-skin immunity axis. Publication Status: Online-Only"
> "Q9EST8-1","RefSeq","NP_085115.1","28391993","In cultured macrophages, LPS-induced expression of monocyte chemoattractant protein (MCP)-1 was suppressed by NaN3 through inhibition of STAT1 and IkappaBzeta activities."
> "Q9EST8-1","RefSeq","NP_085115.1","11086164","MAIL localizes in the nucleus, and accelerates IL-6 production by LPS stimulation in mouse fibroblasts."
> "Q8VC16-1","RefSeq","NP_663446.1","27426725","TLR signaling led to lower expression of LRRC14."
> "Q8VC16-1","RefSeq","NP_663446.1","19720120","We define a small core bidirectional promoter that drives expression of the mouse genes Recql4, on one strand, and Lrrc14; a novel member of the LRR gene family, on the opposite strand"
> "Q9ESX2-1","RefSeq","NP_112460.1","29123026","Results demonstrate that KLF14 expression is induced in the livers of normal C57BL/6J mice upon fasting and significantly up-regulated in the livers of db/db mice, suggesting a physiological link between KLF14 and gluconeogenesis."
> "Q9ESX2-1","RefSeq","NP_112460.1","28962896","Whole body loss of KLF14 function in male mice does not result in metabolic abnormalities as assessed under chow and HFD conditions."
> "Q9ESX2-1","RefSeq","NP_112460.1","27787957","Epfn preserves the balance between cell proliferation and cytodifferentiation in dental epithelial and mesenchymal cells during normal tooth development and morphogenesis."
> "Q9ESX2-1","RefSeq","NP_112460.1","25344255","Epiprofin (Epfn, also known as Sp6) plays crucial distinct roles in these transition stages as a cell cycle regulator and a transcription factor."
> "Q9ESX2-1","RefSeq","NP_112460.1","25166858","Our data are compatible with Sp6 and Sp8 working together and in a dose-dependent manner as indispensable mediators of Wnt/betacatenin and Bmp signaling in the limb ectoderm Publication Status: Online-Only"
> "Q9ESX2-1","RefSeq","NP_112460.1","14551215","Epiprofin is a highly cell- and tissue-specific nuclear protein expressed primarily by proliferating epithelial cells of teeth, hair follicles, and limbs that may function in the development of these tissues by regulating cell growth"
14199,14200c19100,19109
< "Q8BID6-1","RefSeq","NP_081932.1","22615130","Expression of the Btbd4 defines the classical dendritic cell lineage"
< "Q8BID6-1","RefSeq","NP_081932.1","22615127","Zbtb46 may help enforce dendritic cell identity by restricting responsiveness to non-dendritic cells growth factors and may serve as a useful marker to identify rare dendritic cell progenitors"
---
> "Q80XR2-1","RefSeq","NP_778190.3","30228103","SPCA1 promotes neurulation by regulating the cytoskeletal dynamics Publication Status: Online-Only"
> "Q80XR2-1","RefSeq","NP_778190.3","24530912","The timing, magnitude of TMEM165 expression and its Golgi location supports a role for this Golgi Ca2+/H+ antiporter as a contributor to mammary Golgi calcium transport needs, in addition to the better-characterized roles of SPCA 1 and 2."
> "Q80XR2-1","RefSeq","NP_778190.3","19793975","Impaired cellular divalent calcium ion Ca2+ homeostasis and/or the altered targeting of organellar proteins under conditions of SPCA1 knockdown highlight the importance of SPCA1 function for normal neural differentiation."
> "Q80XR2-1","RefSeq","NP_778190.3","18599310","Has a potential role in intracellular signaling and in Golgi secretory processes involved in dendritic growth and in functional maturation of the mouse nervous system."
> "Q80XR2-1","RefSeq","NP_778190.3","17597066","Loss of the Golgi Ca(2+) pump causes Golgi stress, expansion of the Golgi, increased apoptosis, and embryonic lethality and demonstrates that SPCA1 haploinsufficiency causes a genetic predisposition to cancer."
> "O09039-1","RefSeq","NP_032533.1","31110180","Study found that LNK is significantly elevated in cutaneous melanoma; this elevation is correlated with hyperactive signaling of the RAS-RAF-MEK pathway. Elevated LNK enhances cell growth and survival in adverse conditions. Forced expression of LNK inhibits signaling by interferon-STAT1 and suppresses interferon induced cell cycle arrest and cell apoptosis. Publication Status: Online-Only"
> "O09039-1","RefSeq","NP_032533.1","30254368","Data indicate that linker of T-cell receptor pathways protein(Lnk) deficiency restores phenotypic hematopoietic stem cells (HSCs) in Fanconi anemia, complementation group D2 protein knockout (Fancd2-/-) mice. Publication Status: Online-Only"
> "O09039-1","RefSeq","NP_032533.1","28526415","The LNK plays a regulatory role in the palmitate-related preadipocyte apoptosis and might be involved in adipose tissue dysfunction."
> "O09039-1","RefSeq","NP_032533.1","12517931","Lnk overexpression in transgenic mice results in impaired expansion of lymphoid precursor cells and altered mature B cell subpopulations."
> "O09039-1","RefSeq","NP_032533.1","11805142","Lnk plays critical roles in the expansion and function of early hematopoietic progenitors Erratum:[J Exp Med 2002 May 6;195(9):1229]"
14202a19112,19113
> "Q6ZPK0-10","RefSeq","NP_620094.2","16684532","Bhc80 is indispensable for the survival of neonatal pups."
> "Q6ZPK0-10","RefSeq","NP_620094.2","15325272","Presumably serves as a scaffold protein in BHC in neuronal as well as non-neuronal cells. Possible role in spermatogenesis."
14207a19119,19123
> "Q8BSP2-1","RefSeq","NP_001258530.1","27737961","Mice inheriting missense mutations in a condensin II subunit (Caph2(nes)) develop T-cell lymphoma"
> "Q8BSP2-1","RefSeq","NP_001258530.1","25961503","Condensin II (beta-kleisin) has an essential role during meiosis I in mouse oocytes and its function overlaps with that of condensin I (gamma-kleisin), which is otherwise redundant"
> "Q8BSP2-1","RefSeq","NP_001258530.1","25474630","Condensins I and II have overlapping and non-overlapping functions in Neural stem cells. Publication Status: Online-Only"
> "Q8BSP2-1","RefSeq","NP_001258530.1","22333158","We confirm that Ncaph2 can generate three different N-termini, all encoded by exon 1, one of which is translated from an alternative reading frame."
> "Q8BSP2-1","RefSeq","NP_001258530.1","17640884","Define a unique lineage-specific requirement for kleisin beta in mammalian T cell differentiation"
14213,14215c19129
< "O54714-1","RefSeq","NP_001159421.1","29896300","PIAS3-mediated feedback loops control cell proliferation and function as robust driving forces for Colitis-associated colorectal cancer (CAC) progression. Publication Status: Online-Only"
< "O54714-1","RefSeq","NP_001159421.1","27845432","Results show that PIAS3 levels are reduced in a mouse model of atherosclerotic lesions and that its expression decreases in conjunction with increases in interleukin-6 expression and disease severity. These findings provide evidence that results indicate that PIAS3 is a critical repressor of atherosclerosis progression. Publication Status: Online-Only"
< "O54714-1","RefSeq","NP_001159421.1","25713074","Data indicate that PIAS3 (protein inhibitor of activated STAT3) interaction modulates EKLF (erythroid Kruppel-like factor) activity in a promoter-dependent and SUMO-independent manner."
---
> "Q921R4-1","RefSeq","NP_083149.3","29540721","The study indicates that DRiP78 levels are elevated in mice that express higher general cognitive ability, raising the possibility that a larger pool of sequestered D1 receptors is available for insertion into the membrane in response to cognitive demands. Publication Status: Online-Only"
14221a19136,19137
> "Q4FZD7-1","RefSeq","NP_898975.2","21245385","Plk5 is mostly expressed in the brain of both mice and humans, and it modulates the formation of neuritic processes upon stimulation of the brain-derived neurotrophic factor (BDNF)/nerve growth factor (NGF)-Ras pathway in neurons."
> "Q4FZD7-1","RefSeq","NP_898975.2","20100802","DNA and protein sequence analyses show that Plk5 shares more similarities with Plk2 and Plk3 than with Plk1 and Plk4."
14226,14227c19142,19144
< "Q60634-1","RefSeq","NP_001035493.1","27993509","This study suggests that reggie-1 and reggie-2 function at Rab11a recycling containers in the transport of PSD-95, N-cadherin, GluA1 and GluN1, and promote (together with significant signaling molecules) spine-directed trafficking, spine synapse formation and the in vitro correlate of LTP. Erratum:[Exp Neurol. 2017 Jul;293:200. PMID: 28292530]"
< "Q60634-1","RefSeq","NP_001035493.1","26313572","These results indicated that miR-124 could potentially play a role in caveolin-independent vesicle trafficking and modulation of flotillin-2 expression in mouse acrosome biogenesis. Publication Status: Online-Only"
---
> "P55292-1","RefSeq","NP_038533.1","30115995","These results demonstrate that Dsg2, but not desmocollin 2 is required for the integrity of the intestinal epithelial barrier in vivo"
> "P55292-1","RefSeq","NP_038533.1","28339476","Cardiac specific overexpression of desmocollin-2 induces necrosis, acute inflammation and patchy cardiac fibrotic remodeling leading to fulminant biventricular cardiomyopathy. Publication Status: Online-Only"
> "P55292-1","RefSeq","NP_038533.1","27834139","Downregulation of DSC2 is associated with arrhythmogenic cardiomyopathy."
14228a19146,19147
> "Q8BFU0-1","RefSeq","NP_766403.1","30206360","These results suggest that SMN-derived Rspo2 plays a major role in AChR clustering and NMJ formation in the postsynaptic region, and muscle-derived Rspo2 also plays a substantial role in juxtaposition of the active zones and synaptic folds. Publication Status: Online-Only"
> "Q8BFU0-1","RefSeq","NP_766403.1","30146491","RSPO2, but not SPON1, specifically promoted the differentiation of midbrain dopaminergic (mDA) neuroblasts into mDA neurons in mouse primary cultures and embryonic stem cells (ESCs)."
14232a19152
> "Q9JHE7-1","RefSeq","NP_064681.1","10915772","The orthologous gene pair, Tssc4/TSSC4, shows difference in imprinting between mouse and human. Mouse Tssc4 gene is imprinted, with preferential expression from the maternal allele in placenta, whereas, human TSSC4 gene is not imprinted."
14240a19161,19165
> "Q3TKT4-1","RefSeq","NP_035547.2","30372823","The study highlights a potential role of Brg1 in regulating cerebral ischemia/reperfusion injury in vivo."
> "Q3TKT4-1","RefSeq","NP_035547.2","30049497","BRG1 knockdown in the vascular endothelium suppressed neutrophil infiltration and down-regulated the levels of inflammation mediators in cardiac ischemia-reperfusion injury."
> "Q3TKT4-1","RefSeq","NP_035547.2","30149919","An increase in Brg1 and a decrease in the PI3K/Akt/mTOR pathway activity were detected in asthmatic mice, but not in control mice. When Brg1 was knocked out, the asthma severity was ameliorated and the PI3K/Akt/mTOR pathway was activated."
> "Q8CE90-1","RefSeq","NP_036074.2","29352108","SENP3 potentiates lipopolysaccharide-induced TLR4 signaling via deSUMOylation of MKK7 leading to enhancement in JNK phosphorylation and the downstream events"
> "Q8CE90-1","RefSeq","NP_036074.2","28779160","We generated neuron-specific Mkk7 knockout mice (MKK7 cKO), which impaired constitutive activation of JNK in the nervous system. MKK7 cKO mice displayed impaired circadian behavioral rhythms and decreased locomotor activity. MKK7 cKO mice at 8 months showed motor dysfunctions such as weakness of hind-limb and gait abnormality in an age-dependent manner. Publication Status: Online-Only"
14244a19170,19175
> "Q8K0T4-1","RefSeq","NP_705800.1","30448058","More active and more stable katanin subunit, KATNAL1, plays more important role in process elongation."
> "Q8K0T4-1","RefSeq","NP_705800.1","22654668","The identification of KATNAL1 as an essential regulator of male fertility provides a significant novel entry point into advancing our understanding of how SC microtubule dynamics promotes male fertility"
> "Q65CL1-1","RefSeq","NP_808280.2","29467248","Alpha-catenins regulate intercalated disc maturation and actomyosin contractility, which, in turn, control Yap subcellular localization, thus providing an explanation for the loss of proliferative capacity in the newborn mammalian heart. Publication Status: Online-Only"
> "Q65CL1-1","RefSeq","NP_808280.2","25480337","AlphaT-catenin may contribute to asthma through a mechanism independent of inflammation and related to heart and pulmonary vein dysfunction."
> "Q65CL1-1","RefSeq","NP_808280.2","17535849","By providing an extra link between the cadherin-catenin complex and intermediate filaments, the binding of alphaT-catenin to plakophilin-2 is proposed to be a means of modulating and strengthening cell-cell adhesion between cardiac muscle cells."
> "A0A338P791-1","RefSeq","NP_001155304.1","17954925","Tint interacts with brachyury 2 but not with brachyury T1; T2 may be part of the T1 regulatory region through direct or indirect participation of tint GeneRIF: An unlinked modifier of Brachyury (T) called tint, interacts with T2 but not with T1. Highly conserved genomic sequences between mice and humans map to the distal end of T2. T2 may embed the long sought mammalian notochord enhancer of Brachyury."
14249a19181
> "P70429-1","RefSeq","NP_031991.3","28320969","EVL selectively mediate activated T-cell trafficking by promoting the diapedesis step of transendothelial migration in a alpha4 integrin-dependent manner."
14259,14260c19191
< "Q8CH20-1","RefSeq","NP_001297390.1","17342728","Human VCX/Y, SPANX, and CSAG2 gene families together with the murine SPANX gene and the CYPT family may share a common ancestor."
< "Q8CH20-1","RefSeq","NP_001297390.1","15286030","CYPT1 and the proteins of the paralogous genes constitute a novel, basic cysteine-rich sperm protein family that may contribute to the function of the postacrosomal PT during nuclear shaping."
---
> "Q80XU5-1","RefSeq","NP_001074783.1","27329800","The present data thus provide evidence for a limited role for changes in VPS13C expression in conferring altered type 2 diabetes risk at this locus, particularly in females, and suggest that C2CD4A, but not C2CD4B, may also be involved."
14265,14268d19195
< "Q61818-1","RefSeq","NP_001032853.1","30275311","Haploinsufficiency of Retinoic Acid Induced 1 causes Smith-Magenis syndrome."
< "Q61818-1","RefSeq","NP_001032853.1","27693255","Rai1 preferentially occupies DNA regions near active promoters and promotes the expression of a group of genes involved in circuit assembly and neuronal communication. Behavioral analyses demonstrated that pan-neural loss of Rai1 causes deficits in motor function, learning, and food intake."
< "Q61818-1","RefSeq","NP_001032853.1","25752576","Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production."
< "Q61818-1","RefSeq","NP_001032853.1","25127133","Mice haploinsufficient for Rai1 fed a high carbohydrate or a high fat diet gained weight at a significantly faster rate than their wild type littermates. Erratum:[PLoS One. 2014;9(11):e114092. Hahn, Natalie H [corrected to Hahn, Natalie C]] Publication Status: Online-Only"
14279a19207,19212
> "Q03160-1","RefSeq","NP_034476.1","24336674","GRB7 gene expression in uterus during embryo implantation is regulated by Mmu-miR-193."
> "Q03160-1","RefSeq","NP_034476.1","20622016","Findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy."
> "Q60980-1","RefSeq","NP_032479.1","29348304","MiR-20a-5p promotes adipocyte differentiation from bone marrow-derived stromal cells by targeting and negatively regulating Klf3 in the early phase during the procedure of adipogenesis."
> "Q60980-1","RefSeq","NP_032479.1","28541545","KLF1 and KLF3 bind common as well as unique sites within the erythroid cell genome."
> "Q60980-1","RefSeq","NP_032479.1","27226561","Mechanistic insights into the regulation of Lgals3, demonstrating that C-terminal binding protein (CtBP) is required to drive optimal KLF3-mediated silencing."
> "Q60980-1","RefSeq","NP_032479.1","26092481","Cineromycin B inhibited adipocyte differentiation in 3T3-L1 cells mainly via upregulation of KLF2 and KLF3 mRNA expression at an early stage of the differentiation."
14287a19221,19223
> "Q6PGG6-1","RefSeq","NP_932778.1","19487455","GNL3L mediates the mitotic increase of TRF1 protein and promotes the metaphase-to-anaphase transition."
> "Q6PGG6-1","RefSeq","NP_932778.1","17623774","Work reveals a novel mechanism that negatively regulates the transcriptional function of ERRgamma (estrogen-related receptor)by GNL3L through coactivator competition."
> "Q9EQD0-1","RefSeq","NP_073558.2","28840375","FZD5 is a receptor for SFRP2 and mediates SFRP2-induced angiogenesis via calcineurin/NFATc3 pathway in endothelial cells."
14294a19231
> "Q3URQ0-1","RefSeq","NP_758508.2","25936917","Tex10 is a core component of the pluripotency network."
14309c19246,19250
< "Q99M96-1","RefSeq","NP_001276553.1","15485929","Suppressor of tumorigenicity 7 (ST7) and nonmetastatic 23 (NM23) are direct targets of PRMT5-containing BRG1 and hBRM complexes"
---
> "Q6P5F6-1","RefSeq","NP_766241.2","29078349","The results indicate that ZIP10 plays important roles in epidermal development via, at least in part, the ZIP10-zinc-p63 signaling axis, thereby highlighting the physiological significance of zinc regulation in the maintenance of skin epidermis."
> "Q6P5F6-1","RefSeq","NP_766241.2","28098160","PrP and ZIP6 inherited the ability to interact with NCAM1 from their common ZIP ancestors but have since diverged to control distinct posttranslational modifications of NCAM1. Publication Status: Online-Only"
> "Q6P5F6-1","RefSeq","NP_766241.2","25074919","Zip10-deficiency in mature B cells attenuated both T-cell-dependent and -independent immune responses in vivo. The Zip10-deficient mature B cells proliferated poorly in response to BCR cross-linking, as a result of dysregulated BCR signaling."
> "Q6P5F6-1","RefSeq","NP_766241.2","25074913","Genetic ablation of Zip10 in early B-cell stages resulted in significant reductions in B-cell populations, and the inducible deletion of Zip10 in pro-B cells increased the caspase activity in parallel with a decrease in intracellular Zn levels."
> "Q6P5F6-1","RefSeq","NP_766241.2","18936201","The expression of Slc30a1, Slc39a8, and Slc39a10 in the erythrocytes of zinc deficient and replete mice is reported."
14325a19267,19271
> "Q9JM13-1","RefSeq","NP_064367.1","27820702","Findings reveal a key role for RABGEF1 in dampening keratinocyte-intrinsic MYD88 signaling and sustaining epidermal barrier function"
> "Q9JM13-1","RefSeq","NP_064367.1","27411398","AP-1/sigma1A-ArfGAP1-Rabex-5 complex formation leads to more endosomal Rabex-5 and enhanced, Rab5(GTP)-stimulated Vps34 PI3-kinase activity, which is essential for multivesicular body endosome formation. Publication Status: Online-Only"
> "Q9JM13-1","RefSeq","NP_064367.1","25427001","Knockdown of RABEX-5 also inhibited wound healing, migration and the invasive abilities of gastric cancer cells. Publication Status: Online-Only"
> "Q9JM13-1","RefSeq","NP_064367.1","24932807","Hyperinsulinemia induced insulin resistance in 3T3-L1 adipocytes by retaining GLUT4 in a Rab5-activity-dependent compartment."
> "Q9JM13-1","RefSeq","NP_064367.1","15235600","RabGEF1 is a negative regulator of Fc epsilon RI-dependent mast cell activation, and a lack of RabGEF1 results in the development of skin inflammation in vivo."
14330a19277,19280
> "Q6R3M4-1","RefSeq","NP_001276445.1","28077248","Exon 2 deletion abrogates both the DNA polymerase and dRP lyase activities of Pol iota in the presence of either Mg(2+) or Mn(2+) ions. Thus, 129-derived strains of mice express catalytically inactive alternatively spliced Pol iota variant."
> "Q6R3M4-1","RefSeq","NP_001276445.1","28077247","Mouse DNA polymerase iota lacking exon 2 (42 amino acids) is catalytically inactive in vitro."
> "Q6R3M4-1","RefSeq","NP_001276445.1","27455952","Pol iota occasionally accesses the replication fork to generate a first mutation, and Pol zeta extends the mismatch with a second mutation."
> "Q6R3M4-1","RefSeq","NP_001276445.1","12925679","Data suggest that either DNA polymerase iota does not participate in hypermutation, or its role is nonessential and can be readily assumed by another low-fidelity polymerase."
14334a19285
> "P51175-1","RefSeq","NP_032937.1","11929049","Isolation, characterization and localization of gene."
14340a19292,19296
> "Q9DB70-1","RefSeq","NP_082334.1","29540794","Results confirmed that CK2alpha serves as a negative regulator of mitochondrial homeostasis via suppression of FUNDC1-required mitophagy, favoring the development of cardiac IR injury."
> "Q9DB70-1","RefSeq","NP_082334.1","29744594","By facilitating Mff-mediated mitochondrial fission and FUNDC1-required mitophagy, NR4A1 disturbed mitochondrial homeostasis, enhanced endothelial apoptosis and provoked microvascular dysfunction in myocardial ischemia reperfusion injury. Publication Status: Online-Only"
> "Q9DB70-1","RefSeq","NP_082334.1","28942427","FUNDC1 binds to IP3R2 to modulate ER Ca(2+) release into mitochondria and cytosol. Disruption of the FUNDC1 and IP3R2 interaction lowers the levels of Ca(2+) in mitochondria and cytosol, both of which instigate aberrant mitochondrial fission, mitochondrial dysfunction, cardiac dysfunction, and heart failure."
> "Q9DB70-1","RefSeq","NP_082334.1","28732308","FUNDC1 is required for cardiac ischemia reperfusion injury activated mitophagy."
> "Q9DB70-1","RefSeq","NP_082334.1","24573672","MicroRNA-137 has a role in inhibiting mitophagy via regulation of two mitophagy receptors FUNDC1 and NIX"
14347a19304,19305
> "O88879-1","RefSeq","NP_033814.2","29596528","Data collectively demonstrated that Apaf1 is a negative regulator of T cell responses and implicated Apaf1 as a potential target for immunosuppressive drug discovery Publication Status: Online-Only"
> "O88879-1","RefSeq","NP_033814.2","27580417","MiR-183 was induced in protective postconditioning and reduced reperfusion injury of the livers via the targeting of apoptotic signaling. miR-183 mediated the tolerance induced by iPoC in livers via Apaf-1 repressing."
14352a19311,19315
> "Q6PHZ2-1","RefSeq","NP_076302.1","29992531","In summary, CaMKIIdelta and CaMKIIgamma are novel ischemia/reperfusion-induced genes that promote neuronal survival during ischemic injury. The upregulation of these CaMKII kinases led to activation of the NF-kappaB signaling pathway, which protects neurons from ischemic damage."
> "Q6PHZ2-1","RefSeq","NP_076302.1","30571348","Activation of CaMKIIdelta in response to pressure overload triggers inflammatory gene expression and activation of the NOD-like receptor pyrin domain-containing protein 3 inflammasome in cardiomyocytes. These responses provide signals for macrophage recruitment, fibrosis, and myocardial dysfunction in the heart."
> "Q6PHZ2-1","RefSeq","NP_076302.1","29360953","JNK2 activation up-regulates CaMKIIdelta expression in the aged atrium and may promote the occurrence of cardiac arrhythmias."
> "Q6PHZ2-1","RefSeq","NP_076302.1","28383548","Surgical-induced Osteoarthritis mice treated with a miR-146a inhibitor significantly alleviated the destruction of articular cartilage via targeting Camk2d and Ppp3r2. Publication Status: Online-Only"
> "Q6ZQ08-1","RefSeq","NP_835179.1","26807845","Collectively, our data support a model of CNOT7, TOB1, CNOT1, and RNA-binding proteins collectively exerting post-transcriptional control on a metastasis suppressive transcriptional program to drive tumor cell metastasis Publication Status: Online-Only"
14368a19332,19334
> "Q8VFV4-1","RefSeq","NP_666895.1","29438653","Stereochemical study of mouse muscone receptor MOR215-1"
> "Q8VFV4-1","RefSeq","NP_666895.1","24361078","This study identified that MOR215-1 was a specific muscone receptor expressed by neurons innervating the muscone-responsive anteromedial glomeruli."
> "Q61116-1","RefSeq","NP_033593.1","8617494","Zfp93 zinc finger protein 93"
14373a19340,19343
> "Q9QYY8-1","RefSeq","NP_058658.2","30213879","Two isoforms of spastin harboring the same missense mutation bind and bundle different subsets of microtubules. Publication Status: Online-Only"
> "Q9QYY8-1","RefSeq","NP_058658.2","28392418","Spastin regulates VAMP7-containing vesicles trafficking in cortical neurons."
> "Q9QYY8-1","RefSeq","NP_058658.2","27773584","Axon branch loss at the developing mouse neuromuscular junction is mediated by branch-specific microtubule severing, mediated by the microtubule-severing enzyme spastin."
> "Q9QYY8-1","RefSeq","NP_058658.2","24065130","Spastin is recruited by microtubules polyglutamylation, induced by Tau missorting triggered translocalization of TTLL6 (Tubulin-Tyrosine-Ligase-Like-6) into dendrites"
14374a19345,19348
> "Q791V5-1","RefSeq","NP_062732.1","30510213","Mitochondrial carrier homolog 2 protein (MTCH2) knockout (-/-) embryonic stem cells (ESCs) fail to elongate their mitochondria and to alter their metabolism. Publication Status: Online-Only"
> "Q791V5-1","RefSeq","NP_062732.1","30401654","Mitochondrial Carrier Homolog 2 forebrain conditional knockout mice exhibit impaired spatial but not motor learning and an impairment in long-term potentiation in hippocampal slices."
> "Q791V5-1","RefSeq","NP_062732.1","28276496","MTCH2 is a critical player in neuronal cell biology, controlling mitochondria metabolism, motility and calcium buffering to regulate hippocampal-dependent cognitive functions. Publication Status: Online-Only"
> "Q791V5-1","RefSeq","NP_062732.1","28127879","MTCH2 is a conserved regulator of lipid homeostasis. MTCH2 was found to be both required and sufficient for lipid homeostasis shifts, suggesting that pharmacological inhibition of MTCH2 could be therapeutic for treatment of obesity and related disorders. MTCH2 could influence lipid homeostasis through inhibition of ESR1 activity."
14381a19356,19359
> "P47746-1","RefSeq","NP_031752.1","30643290","Knockdown of CB1R in the CCK-D2 medium spiny neurons circuit elevated synaptic activity and promoted stress susceptibility. Erratum:[Nat Med. 2019 Jan 30;:. PMID: 30700866]"
> "Q60716-1","RefSeq","NP_035161.2","26001784","Impaired extracellular matrix is the primary cause of death of C-P4H-I+/-;C-P4H-II-/- growth plate chondrocytes."
> "Q60716-1","RefSeq","NP_035161.2","22930750","C-P4H alpha(I) and alpha(II) mRNA levels were increased in hypoxic mouse chondrocytes in a manner dependent on HIF-1a."
> "P41317-1","RefSeq","NP_034906.1","30351498","MBL may be exploited as a new therapeutic approach in the treatment of chemical-induced sterile liver injury in patients with MBL deficiency."
14382a19361
> "Q9CPW0-1","RefSeq","NP_080047.1","29901787","This study demonstrated that cntnap2 knockout affect the neuronal pathway development in mice."
14396a19376
> "Q9D824-1","RefSeq","NP_077145.2","16690743","FIP1L1-PDGFRalpha activation requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent"
14405a19386
> "P70675-1","RefSeq","NP_033466.1","21912526","Tsx performs general functions in multiple cell types and links the noncoding locus to stem and germ cell development, learning, and behavior in mammals."
14409a19391,19395
> "Q9CZW4-1","RefSeq","NP_083093.2","19737935","ACSL3 expression is up-regulated in ob/ob mice and mice fed a high sucrose diet"
> "E9Q6R7-1","RefSeq","NP_035812.3","29879154","Findings show that utrophin haploinsufficiency does not worsen the functional performance of mdx mice and the force production of EDL muscles suggest that the monoallelic expression level of utrophin is sufficient in mdx/utrn+/- mice to prevent further deterioration of the muscle. Publication Status: Online-Only"
> "E9Q6R7-1","RefSeq","NP_035812.3","29772070","As the more efficient utrophin-based response in mdx skeletal muscle appears to involve independent transcriptional activation of conserved, myogenic isoforms (A' and F), elevating their paralogues in DMD patients is an encouraging therapeutic strategy."
> "E9Q6R7-1","RefSeq","NP_035812.3","29408646","Utrophin up-regulation by artificial transcription factors induces muscle rescue and impacts the neuromuscular junction in mdx mice."
> "E9Q6R7-1","RefSeq","NP_035812.3","29065908","Utrophin levels influence mitochondrial pathology and oxidative stress in mdx myofibers. Publication Status: Online-Only"
14416a19403
> "P97329-1","RefSeq","NP_033030.1","30006548","It has been reported that mitotic kinesin KIF20A interacts with RGS3 and plays a crucial role in controlling the division modes of neural progenitor cells during cortical neurogenesis. Publication Status: Online-Only"
14439a19427
> "Q8CDF7-1","RefSeq","NP_766445.1","26669262","PiRNA biogenesis triggered by PIWI slicing, and promoted by EXD1, ensures that the same guides instruct PIWI proteins in the nucleus and cytoplasm."
14450a19439,19441
> "Q66JT0-1","RefSeq","NP_958758.2","23616086","WEE1B acts as a direct downstream substrate of protein kinase A (PKA) and that Ser 15 of WEE1B is a potential PKA phosphorylation target in the G2/M transition of mouse embryos."
> "Q66JT0-1","RefSeq","NP_958758.2","21454751","Findings demonstrate that exit from metaphase requires not only a proteolytic degradation of cyclin B but also the inhibitory phosphorylation of Cdc2 by Wee1B"
> "Q66JT0-1","RefSeq","NP_958758.2","16169490","Wee1B is a key maturation-promoting-factor inhibitory kinase in mouse oocytes, functions downstream of PKA, and is required for maintaining meiotic arrest."
14454a19446,19448
> "Q11131-1","RefSeq","NP_038552.1","27591321","The DNA demethylation within the fut7 gene controls selectin ligand expression in mice, including the inducible topographic commitment of T cells for skin and inflamed sites."
> "A4UUI3-1","RefSeq","NP_001242934.1","22095711","GBP4 is a negative regulator of virus-triggered type I interferon (IFN-I) production, interacting as a novel protein targeting interferon regulatory factor (IRF)-7 and inhibiting its function."
> "A4UUI3-1","RefSeq","NP_001242934.1","17919070","Two splice variants of mGBP4 could be detected. One variant led to a premature stop codon after 312 bp. The second variant resulted in a transcript with a disrupted G2 domain."
14457,14465c19451,19471
< "Q8BUG5-1","RefSeq","NP_001297604.1","30389842","Epigenetic tuning of CAPS variants may allow modulation of endocrine adrenaline and noradrenaline release"
< "Q8BUG5-1","RefSeq","NP_001297604.1","28963059","That CAPS2 deficiency strongly impairs hippocampal adult neurogenesis and maturation of newborn neurons"
< "Q8BUG5-1","RefSeq","NP_001297604.1","25754523","These results suggest that Caps2 KO mice have altered endocrine responses to CORT administration, while maintaining CORT-induced anxiety/depressive-like behavior. Publication Status: Online-Only"
< "Q8BUG5-1","RefSeq","NP_001297604.1","25437547","Naturally occurring splice variants of CAPS2 in CAPS1/CAPS2-deficient cells were studied and found that CAPS2 primes vesicles independently of its MUN domain."
< "Q8BUG5-1","RefSeq","NP_001297604.1","22111578","CAPS family proteins exert dual roles in DCV trafficking, mediating trafficking at both the secretion site for exocytosis and at the Golgi complex for biogenesis"
< "Q8BUG5-1","RefSeq","NP_001297604.1","21173225","CAPS2 promotes activity-dependent brain-derived neurotrophic factor secretion during the postnatal period that is critical for the development of hippocampal GABAergic networks."
< "Q8BUG5-1","RefSeq","NP_001297604.1","20302894","CAPS2 KO mice will be a useful animal model to study the aspects of the neuropathology and behavior characteristics of neurodevelopmental disorders Review article"
< "Q8BUG5-1","RefSeq","NP_001297604.1","19238500","The CAPS2-deficient mice show reduced secretion of BDNF and NT-3. And the cerebella of these mice exhibit developmental deficits, such as delayed development. Review article"
< "Q8BUG5-1","RefSeq","NP_001297604.1","11846421","Discusses cloning of the human homolog of mouse Caps2 (GeneID: 353025)."
---
> "Q8BWJ4-1","RefSeq","NP_766219.2","28888937","Depletion of LDLRAD4 in HepG2 liver cancer cells inhibited tumorigenesis in nude mice. These results reveal an oncogenic role of LDLRAD4 in tumorigenesis through its association with Nedd4."
> "Q8BVZ1-1","RefSeq","NP_080150.2","30954078","Our data highlight a protective role of Plin5 against hepatic lipotoxic injuries induced by HCV NS5A, which is helpful for understanding the steatosis and injuries in liver during HCV infection. Publication Status: Online-Only"
> "Q8BVZ1-1","RefSeq","NP_080150.2","30617219","Study show that Plin5 is an important modulator of intrahepatic lipid metabolism and suggest that the increased Plin5 expression that occurs with overnutrition may play an important role in preventing hepatic insulin resistance."
> "Q8BVZ1-1","RefSeq","NP_080150.2","29378767","Changes in lipid metabolism resulting from PLIN5 deletion reduce ER stress in muscle, decrease FGF21 production by muscle and liver, and impair glycemic control."
> "Q8BVZ1-1","RefSeq","NP_080150.2","29317465","Perilipin 5 and liver fatty acid binding protein function to restore quiescence in mouse hepatic stellate cells"
> "Q8BVZ1-1","RefSeq","NP_080150.2","28919478","The results indicated that atorvastatin promoted lipolysis and reduced TG accumulation in the liver by increasing PKA-mediated phosphorylation of Plin5. This new mechanism of lipid-lowering effects of atorvastatin might provide a new strategy for NAFLD treatment."
> "Q8BVZ1-1","RefSeq","NP_080150.2","17234449","We have characterized a novel PAT protein, lipid storage droplet protein 5 (LSDP5) of 463 residues.The LSDP5 gene is primarily transcribed in cells that actively oxidize fatty acids, such as heart, red muscle and liver."
> "Q8BVZ1-1","RefSeq","NP_080150.2","16571721","MLDP is a novel PAT family protein localized to lipid droplets and enriched in the heart, and regulated by peroxisome proliferator-activated receptor alpha"
> "P15379-14","RefSeq","NP_033981.2","30582228","High CD44 expression is associated with testicular germ cell tumor."
> "P15379-14","RefSeq","NP_033981.2","30395540","An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion."
> "O54785-1","RefSeq","NP_774958.1","29319181","The small GTPase RhoA regulated LIMK1/2-cofilin to modulate cytoskeletal dynamics during mouse oocyte meiosis."
> "O54785-1","RefSeq","NP_774958.1","28669900","Results demonstrate an important role for LIMKs in central sensitization and the development of chronic pain"
> "Q91ZM2-1","RefSeq","NP_035493.2","29180441","Brain-specific Sh2b1 knockout (KO) mice exhibited brain growth retardation and reactive aggression."
> "Q91ZM2-1","RefSeq","NP_035493.2","29631267","The increased expression of genes in leptin (JAK/STAT or AKT) signaling implies that the main mode of action for SH2B1 mutations might affect leptin signaling rather than insulin signaling. Erratum:[Obes Facts. 2018;11(3):176-180. PMID: 29739001]"
> "Q91ZM2-1","RefSeq","NP_035493.2","27217487","Data identify SH2B1 as a major regulator of IRS2 stability, demonstrate a novel feedback mechanism linking mTORC1 signaling with IRS2, and identify 4E-BP2 as a major regulator of proliferation and survival of beta-cells."
> "Q91ZM2-1","RefSeq","NP_035493.2","18247337","An essential role of the SH2B1 variants in the activation of the Src kinase and the resulting mitogenic response--extending to phenotypic cell transformation and involving the established Src substrate STAT3"
> "O70348-1","RefSeq","NP_291091.2","23523372","Report Dom3Z has role in pre-mRNA 5' end capping quality control mechanism and suggest link between proper 5' end capping and subsequent pre-mRNA processing."
> "Q9D0P7-1","RefSeq","NP_064360.1","29378206","PSRC1 protects against the development of atherosclerosis and enhances the stability of plaques by modulating cholesterol transportation and inflammation in macrophages and the liver of apoE(-/-) mice."
> "Q9D0P7-1","RefSeq","NP_064360.1","17310996","DDA3 is a novel microtubule-associated protein that binds to EB3, and results implicate DDA3 and EB3 in the beta-catenin-mediated growth signaling."
> "Q9D0P7-1","RefSeq","NP_064360.1","12427559","Molecular cloning, sequence analysis and gene expression"
> "Q9D0P7-1","RefSeq","NP_064360.1","12082536","A p53 response element mediates transcriptional activation"
14480a19487,19492
> "Q9WVH4-1","RefSeq","NP_062714.1","30973875","FOXO3 directly binds a network of target genes in adult neural stem and progenitor cells (NSPCs) that are involved in autophagy, and we find that FOXO3 functionally regulates induction of autophagy in these cells. Interestingly, in the absence of FOXO activity, protein aggregates accumulate in NSPCs. Publication Status: Online-Only"
> "Q9WVH4-1","RefSeq","NP_062714.1","30718226","The loss of FOXO3-mediated immune landscape, pathways, and transcripts that could serve as biomarkers and new targets for inflammatory colon cancer treatment, were identified."
> "Q9WVH4-1","RefSeq","NP_062714.1","30304480","ZEB1/CtBP and FOXO3 have opposing transcriptional activities and regulate muscle atrophy-related genes"
> "Q9WVH4-1","RefSeq","NP_062714.1","30318050","Results demonstrate that Sirt1 overexpression in MSCs increased the osteoblastic bone formation and partially restores the defects in skeletal growth and osteogenesis in Bmi-1(-/-) mice by FOXO3a deacetylation and oxidative stress inhibition"
> "Q9WVH4-1","RefSeq","NP_062714.1","11884717","Redox regulation through a p66shc-dependent signaling pathway"
> "Q9WVH4-1","RefSeq","NP_062714.1","11875118","Expression in the ovary"
14500a19513,19514
> "O08791-1","RefSeq","NP_034226.1","29869132","The caudo-ventral pallium is a novel pallial domain expressing Gdf10 and generating Ebf3-positive neurons of the medial amygdala."
> "O08791-1","RefSeq","NP_034226.1","29563184","HSC cellular niches express Ebf3 that is required to create HSC niches, to inhibit their osteoblast differentiation, and to maintain spaces for HSCs."
14505a19520
> "Q8CBY8-1","RefSeq","NP_080578.1","21186323","Ankyrin-B then interacts with dynactin-4 and dystrophin, whereas dynactin-4 collaborates with dystrophin in coordinating costamere-aligned microtubules"
14525a19541,19543
> "P58283-1","RefSeq","NP_996993.1","27995769","Missense mutations in TRIAD3 abolished the interaction of TRIAD3A with Arc, disrupting Arc ubiquitination, and consequently Arc degradation."
> "P58283-1","RefSeq","NP_996993.1","28154178","Low RNF216 expression is associated with obesity-induced inflammation."
> "P58283-1","RefSeq","NP_996993.1","25484083","Identifies a novel negative regulator of autophagy and suggests that RNF216 may be a target for treatment of inflammatory diseases"
14529a19548,19554
> "P20181-1","RefSeq","NP_032768.1","30594389","The data suggest that CADPS2-mediated secretion of BDNF/NT-3 may be involved in development and maturation of synapses and in the balance between inhibitory and excitatory synapses."
> "P20181-1","RefSeq","NP_032768.1","29549646","NTF3 is a novel target gene of POU3F2 and that the POU3F2/NTF3 pathway plays a role in the process of neuronal differentiation."
> "P20181-1","RefSeq","NP_032768.1","29523879","Studies for the first time have shown that NT-3 increases muscle fiber diameter in the neurogenic muscle through direct activation of mTOR pathway and that the fiber size increase is more prominent for fast twitch glycolytic fibers"
> "Q9CZ44-1","RefSeq","NP_938085.1","27540115","Our data identify EBP50 as a previously unidentified regulator of Nox1 and support that it promotes Nox1 activity by binding p47(phox) This interaction is pivotal for agonist-induced smooth muscle ROS, hypertrophy, and vasoconstriction and has implications for ROS-mediated physiological and pathophysiological processes."
> "Q9CZ44-1","RefSeq","NP_938085.1","23429921","Data suggest that NADPH oxidase-derived cytosolic superoxide is increased in islets upon oleate exposure and leads to beta cell dysfunction; whole-body NADPH oxidase inhibition (via p47 knockout) decreases superoxide and restores islet function."
> "Q9CZ44-1","RefSeq","NP_938085.1","18403597","Genetic ablation of components of NADPH oxidase enhances susceptibility to the proinflammatory effects of CS leading to airspace enlargement and alveolar damage."
> "Q9CZ44-1","RefSeq","NP_938085.1","14988733","That p47 ubiquitin regulatory X domain domains may act as general p97/valosin containing protein/CDC48 binding modules and that adaptor binding for N-ethylmaleimide sensitive factor and p97 might involve different binding sites"
14539,14543c19564,19565
< "Q8BZN4-1","RefSeq","NP_001181954.1","30446657","Using liver cancer as a model, NUAK2 was identified as an essential mediator of YAP-driven hepatomegaly and tumorigenesis in vivo. Publication Status: Online-Only"
< "Q8BZN4-1","RefSeq","NP_001181954.1","29298809","Data (including data from studies in knockout and transgenic mice) suggest that Nuak2/Snark is involved in both adipose inflammation and energy metabolism in white/brown adipocytes; Nuak2/Snark appears to regulate thermogenesis in brown adipocytes."
< "Q8BZN4-1","RefSeq","NP_001181954.1","26690705","These findings reveal a critical role for SNARK in myocyte survival and the maintenance of muscle mass with age."
< "Q8BZN4-1","RefSeq","NP_001181954.1","20713714","Data show that SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle."
< "Q8BZN4-1","RefSeq","NP_001181954.1","18307533","Obesity was a risk factor for colorectal tumorigenesis in Snark(+/-) mice model."
---
> "Q5DU57-1","RefSeq","NP_001297523.1","31020388","Spata13 modulates social hierarchy in both male and female mice in addition to affecting voluntary activity in females."
> "Q5DU57-1","RefSeq","NP_001297523.1","19893577","Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice. [Asef2, mouse]"
14549a19572,19578
> "P23298-1","RefSeq","NP_032882.2","24705298","Genetic deficiency results in defective suppressive activity of T reg cells"
> "P23298-1","RefSeq","NP_032882.2","22155788","Data suggest that PKCeta shares some redundant roles with PKCtheta; in T cell biology and also performs nonredundant functions that are required for T cell homeostasis and activation Publication Status: Online-Only"
> "P23298-1","RefSeq","NP_032882.2","21602810","These results establish a previously uncharacterized role forPKC-epsilon, PKC-eta, PKC-theta in T cell polarity. Publication Status: Online-Only"
> "P51678-1","RefSeq","NP_034044.3","30106146","CCR3 gene knockout may alleviate Eosinophil (EOS) invasion and the inflammatory response in allergic rhinitis model mice by reducing the expression levels of EOS peroxidase, EOS cationic protein, major basic protein, IL4, and IgE, and increasing the expression of IL10 and IFNgamma."
> "P51678-1","RefSeq","NP_034044.3","29778007","CD193(+) neutrophils increase in number under inflammatory conditions due to chronic IL-21 production."
> "P51678-1","RefSeq","NP_034044.3","29186205","We found abnormalities in sleep patterns in the resting phase and in the number of Hcrt neurons in Ccr3 KO mice. These observations suggest a role for CCR3 in sleep-wake regulation in narcolepsy patients Publication Status: Online-Only"
> "P51678-1","RefSeq","NP_034044.3","27822494","Study found that CCR3 plays a crucial role in neuronal injury. CCR3 deletion or inhibition protects neurons from oxygen-glucose-deprivation-induced cytotoxicity in primary cortical cultures. CCR3 KO mice also displayed significant reduction of infarct volume in the brain after experimental stroke. Publication Status: Online-Only"
14564d19592
< "Q9CWV1-1","RefSeq","NP_001277983.1","22771120","MCM8 and MCM9 form a complex and that they coregulate their stability."
14565a19594,19598
> "Q6HA09-1","RefSeq","NP_766127.1","28911209","Intracellular activation of Astl mediates pre-fertilization hardening of the zona pellucida."
> "Q6HA09-1","RefSeq","NP_766127.1","28114310","Seven amino acid motif near Astl N-terminus is necessary and sufficient for cortical granule localization. Publication Status: Online-Only"
> "Q6HA09-1","RefSeq","NP_766127.1","22472438","Ovastacin is a pioneer component of mouse cortical granules and plays a definitive role in the postfertilization block to sperm binding that ensures monospermic fertilization and successful development"
> "Q6HA09-1","RefSeq","NP_766127.1","22206759","Data show that SAS1B/SAS1R (Sperm Acrosomal SLLP1 Binding/Sperm Acrosomal SLLP1 receptor) bound to sperm acrosomal protein SlLP1 with high affinity."
> "Q6HA09-1","RefSeq","NP_766127.1","22275110","ASTL is dynamically expressed in the embryonic epithelium and in embryonic stem cells, suggesting an important function for the control of epithelial cell behavior during early development."
14567a19601,19615
> "Q3UUF8-1","RefSeq","NP_780664.2","19524877","Cytosolic phosphoprotein DP58 is involved in promyeloid progenitor induction."
> "Q3UUF8-1","RefSeq","NP_780664.2","15358210","Because of its restricted expression in bone-marrow-drived progenitors as a phophorylated protein, it is likely that DP58 may be involved in a signaling pathway for cellular differentiation."
> "Q9JLC3-1","RefSeq","NP_038787.1","28986131","Collectively, the results of this study suggest that selenoprotein MsrB1 plays a protective role against APAP-induced hepatotoxicity via its antioxidative function."
> "Q9JLC3-1","RefSeq","NP_038787.1","28698597","Findings suggest that MsrB1 controls immune responses by promoting anti-inflammatory cytokine expression in macrophages. MsrB1-dependent reduction of oxidized methionine in proteins may be a heretofore unrecognized regulatory event underlying immunity and inflammatory disease. Publication Status: Online-Only"
> "Q9JLC3-1","RefSeq","NP_038787.1","27838938","MsrB1 deficiency does not increase high-fat diet-induced insulin resistance in mice."
> "Q9JLC3-1","RefSeq","NP_038787.1","20634897","Study characterized unexpected diversity of protein and mRNA forms of mammalian selenoprotein MsrB1. Publication Status: Online-Only"
> "Q9JLC3-1","RefSeq","NP_038787.1","19636847","The chemical shift index for MsrB1 indicates that the beta-sheets are the main element for the protein secondary structure."
> "Q8VCS0-1","RefSeq","NP_067294.2","28951252","Study shows sex-dependent alterations in motor and anxiety-like behavior of aged bacterial peptidoglycan sensing molecule 2 (Pglyrp2) knockout mice. The findings suggest a novel role for Pglyrp2 as a key regulator of motor and anxiety-like behavior in late life."
> "Q8VCS0-1","RefSeq","NP_067294.2","26332373","Pglyrp-2 expression was induced after infection in WT mice. Pglyrp-3 expression was low before and after infection in WT mice, while Pglyrp-4 expression was slightly elevated after infection in WT, Pglyrp-2 and -3 null mice Publication Status: Online-Only"
> "Q8VCS0-1","RefSeq","NP_067294.2","22615249","Nod2(-/-) Pglyrp2(-/-) mice displayed increased susceptibility to infection at 24 h postinfection compared to Pglyrp2(-/-). Thus, PGLYRP2 plays a protective role in vivo in the control of S. Typhimurium infection through a Nod1/Nod2-independent mechanism."
> "Q8VCS0-1","RefSeq","NP_067294.2","22048773","Pglyrp2 limits overactivation of Th17 cells by promoting accumulation of regulatory T cells at the site of inflammation in an experimentally induced mouse model of psoriasis"
> "Q8VCS0-1","RefSeq","NP_067294.2","15340057","In contrast to its critical role in immunity in flies, PGRP-L is largely dispensable for mammalian immunity against bacteria and fungi."
> "P41230-1","RefSeq","NP_038696.2","28978483","Loss of Kdm5c causes spurious transcription and prevents the fine-tuning of activity-regulated enhancers in neurons."
> "P41230-1","RefSeq","NP_038696.2","27421841","Neurite growth in Neuro2a cells was suppressed by the KDM5C mutations associated with intellectual disability in patients.  Ntng2 was downregulated in cells with KDM5C mutations, concordant with the lower levels of H3K4 methylation at its promoter."
> "P41230-1","RefSeq","NP_038696.2","27498878","The results identify two key regulators, PCGF6 and JARID1c that temper dendritic cells (DC) activation and implicate active transcriptional silencing via histone demethylation as a previously unappreciated mechanism for regulating DC activation and quiescence."
14577a19626,19628
> "G3X8Q1-1","RefSeq","NP_766137.2","28462391","Calcineurin B1 plays a key role in seizure-induced dendrite growth suppression and may contribute to the neurobehavioral comorbidities of childhood epilepsy Publication Status: Online-Only"
> "G3X8Q1-1","RefSeq","NP_766137.2","19668210","Cabin1 inhibits p53 function on chromatin in the quiescent state; the presence of inactive p53 on some promoters might allow a prompt response upon DNA damage."
> "G3X8Q1-1","RefSeq","NP_766137.2","12114545","Calpain-dependent cleavage activates calcineurin to mediate calcium-triggered cell death."
14586a19638,19644
> "Q8R3B1-1","RefSeq","NP_062650.1","29793503","PLCD1-modified mice (F0) showed progressive hair loss after birth and the genotype of CRISPR/Cas9-induced mutations in exon 2 of PLCD1 locus, suggesting the guide RNA is effective to cause mutations that lead to hair growth defect. Publication Status: Online-Only"
> "Q8R3B1-1","RefSeq","NP_062650.1","29030553","Results show that de novo polarisation of the embryo at the 8-cell stage is directed by phospholipase C (PLC) and protein kinase C (PKC). Publication Status: Online-Only"
> "Q8R3B1-1","RefSeq","NP_062650.1","27371838","Data show that phospholipase C delta1 (PLCD1) transfection can induce the apoptosis of CAPAN-1 and BXPC-3 pancreatic cancer cells, arrest the cell cycle in G0 /G1 phase."
> "Q9ERE3-1","RefSeq","NP_808215.2","30975125","Study data from human hepatocellular carcinoma (HCC) liver samples, human HCC cells, and Sgk3 knockout mice model suggest that SGK3 plays a role in transducing helical domain mutant PIK3CA signaling during liver tumor development. Publication Status: Online-Only"
> "Q9ERE3-1","RefSeq","NP_808215.2","28935820","Taken together, these data strongly suggest that SGK3 plays a significant role in regulating podocyte function, likely by controlling the expression and activity of GSK3."
> "Q9ERE3-1","RefSeq","NP_808215.2","27457803","SGK1 and SGK3 are expressed in multiple microglial cell lines. SGK1 and SGK3 may play an important role in regulating microglial viability and inflammatory responses."
> "Q9ERE3-1","RefSeq","NP_808215.2","26824455","SGK3 is a positive regulator of KCNA5, which is at least partially effective by abrogating the effect of Nedd4-2."
14596a19655
> "Q80TY0-1","RefSeq","NP_062279.1","15252009","FBP17 interacts with dynamin and regulates endocytosis by forming vesicotubular structures."
14606,14607c19665,19668
< "Q80ZD8-1","RefSeq","NP_001004293.1","26240432","The AMIGO1-KCNB1 complex is involved in schizophrenia-related behavioral domains in mice."
< "Q80ZD8-1","RefSeq","NP_001004293.1","22056818","AMIGO is a function-modulating auxiliary subunit for Kv2.1. Publication Status: Online-Only"
---
> "B1AXD8-1","RefSeq","NP_001007590.2","27871306","Data demonstrate a previously-unsuspected role for Akirin2 in early cortical development and, given its known nuclear roles, suggest that it may act to regulate gene expression patterns critical for early progenitor cell behavior and cortical neuron production. Publication Status: Online-Only"
> "B1AXD8-1","RefSeq","NP_001007590.2","28605346","This review discusses current understanding of the molecular mechanisms that have instrumental roles in governing the inflammatory response with special emphasis on Akirin2 in B cells Review article"
> "B1AXD8-1","RefSeq","NP_001007590.2","26041538","The nuclear protein akirin2 has an essential function in B cell activation and humoral immune responses."
> "B1AXD8-1","RefSeq","NP_001007590.2","25107474","The IkappaB-zeta-Akirin2-BAF60 complex physically links the NF-kappaB and SWI/SNF complexes in innate immune cell activation."
14621,14623d19681
< "Q6URW6-1","RefSeq","NP_001258469.1","27385019","We have validated a novel gene, Myh14, as a negative regulator of ISO-induced left ventricular mass hypertrophy in an in vivo mouse model and demonstrated the up-regulation of immediate early gene Myc, fetal gene Nppb, and fibrosis gene Lgals3 in ISO-treated Myh14 deficient hearts compared to controls. Publication Status: Online-Only"
< "Q6URW6-1","RefSeq","NP_001258469.1","28101381","That Myh14 may play a beneficial role in the protection of the cochlea after acoustic overstimulation in CBA/CaJ mice"
< "Q6URW6-1","RefSeq","NP_001258469.1","12598534","A cGMP-independent mechanism for nitric oxide-mediated inhibition of nonmuscle myosin heavy chain II-C induction"
14630a19689,19692
> "Q8VHI4-1","RefSeq","NP_631889.1","26826701","This report that loss of CaRF leads to enhanced NMDAR-dependent induction of both Bdnf IV and the activity-regulated gene Arc, and we investigate potential mechanisms as well as biological consequences of this change in transcriptional regulation."
> "Q8VHI4-1","RefSeq","NP_631889.1","23848551","Carf(+/-) and Carf(-/-) mice were impaired in their ability to acquire timed response thresholds relative to Carf(+/+) mice."
> "Q8VHI4-1","RefSeq","NP_631889.1","20523734","These data strongly support the characterization of CaRF as a unique transcription factor and provide the first insight into the program of CaRF-regulated transcription in neurons. Publication Status: Online-Only"
> "Q8VHI4-1","RefSeq","NP_631889.1","11832226","Cloned as a calcium- and neural-selective transcriptional activator of the gene for Brain-Derived Neurotrophic Factor (BDNF)."
14634,14639c19696,19699
< "Q920C1-1","RefSeq","NP_001107857.1","30344043","Study identified that astrocyte-secreted chordin-like 1 (Chrdl1) is necessary and sufficient to induce mature GluA2-containing synapses to form."
< "Q5RJI5-1","RefSeq","NP_001003920.2","27251228","Structure and inhibition analysis of the mouse SAD-B C-terminal fragment"
< "Q5RJI5-1","RefSeq","NP_001003920.2","27626661","CAST/SAD-B reaction serves as a brake on synaptic transmission"
< "Q5RJI5-1","RefSeq","NP_001003920.2","26444684","At mature pre-synaptic terminals, SAD-B regulates vesicular release probability and synaptic plasticity."
< "Q5RJI5-1","RefSeq","NP_001003920.2","17482548","Once activated, LKB1 phosphorylates and thereby activates SAD-A and SAD-B kinases, which are also required for neuronal polarization in the cerebral cortex."
< "Q5RJI5-1","RefSeq","NP_001003920.2","15705853","Results show that SAD-A and SAD-B, mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization."
---
> "P11031-1","RefSeq","NP_035424.1","27471272","These observations indicate that non-histone chromatin-associated proteins like PC4 play a significant role in neuronal plasticity."
> "P11031-1","RefSeq","NP_035424.1","26740582","Results suggest that positive cofactor 4 (Pc4) has an important role in inducing spontaneous somatic cell reprogramming via up-regulation of key pluripotency genes."
> "P11031-1","RefSeq","NP_035424.1","19047459","Report recruitment of RNA polymerase II cofactor PC4 to DNA damage sites."
> "P11031-1","RefSeq","NP_035424.1","16003322","Redox-mediated upregulation of hepatocyte iNOS transcription requires an HNF-4alpha-PC4 transcriptional complex"
14641a19702,19703
> "Q80V81-1","RefSeq","NP_083189.2","25827285","Results show that Zfp819 is expressed exclusively in spermatogenic cells. Its overexpression suppressed cell proliferation and induced apoptosis."
> "Q80V81-1","RefSeq","NP_083189.2","23954693","Zfp819 is a novel pluripotency-related factor and unveiled its function in genomic integrity maintenance mechanisms of mouse embryonic stem cells."
14647,14650d19708
< "Q62048-1","RefSeq","NP_001316798.1","30049418","This study shows that PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models"
< "Q62048-1","RefSeq","NP_001316798.1","29928894","Epigenetic changes imposed at this region by diets, which impair glucose tolerance generate metabolic memory of the nutritional injury and leave Ped/Pea-15 induction in a poised state."
< "Q62048-1","RefSeq","NP_001316798.1","27426254","The neurological and neurochemical phenotype of transgenic mice overexpressing PED/PEA-15 (tgPED), were analyzed. Publication Status: Online-Only"
< "Q62048-1","RefSeq","NP_001316798.1","19917132","We suggest PEA-15 may be an essential regulator of ERK-dependent spatial learning. Publication Status: Online-Only"
14697,14700d19754
< "Q8C7R7-1","RefSeq","NP_001152861.1","30509498","Rfx6 can directly bind to upstream of MiR-145, MiR-195, and possibly other non-protein-coding functional RNAs to control adult mouse pancreatic differentiation. Interestingly, our study revealed that Rfx6 played an important role in insulin translation by binding to the Eif2ak1, Upf1, and Eif5."
< "Q8C7R7-1","RefSeq","NP_001152861.1","25497096","Rfx6 loss in adult beta cells leads to glucose intolerance, impaired beta cell glucose sensing, and defective insulin secretion."
< "Q8C7R7-1","RefSeq","NP_001152861.1","20148032","Studies demonstrate a unique position for Rfx6 in the hierarchy of factors that coordinate pancreatic islet development in both mice and humans"
< "Q8C7R7-1","RefSeq","NP_001152861.1","20040487","Rfx6 is found in postmitotic islet progenitor cells in the embryo and is maintained in all developing and adult islet cell types. It is dependent on Ngn3 and during islet cell differentiation."
14723,14726d19776
< "Q5SRY7-1","RefSeq","NP_001258276.1","30391586","Investigated beta-TrCP function in Sertoli cells by generating mice with targeted deletion of the beta-TrCP2 gene in Sertoli cells on a background of whole-body beta-TrCP1 knockout. Loss of beta-TrCP in Sertoli cells caused infertility due to a reduction in the number of mature sperm."
< "Q5SRY7-1","RefSeq","NP_001258276.1","30031111","Beta-TrCP was identified as a novel interacting partner of ASK1 that is capable of ubiquitinating and degrading ASK1 through the ubiquitin-proteasome system. These findings suggest that beta-TrCP is capable of suppressing oxidative stress-induced caspase 3-dependent apoptosis through suppression of ASK1."
< "Q5SRY7-1","RefSeq","NP_001258276.1","26240281","The mTOR pathway promotes cell proliferation via beta-TrCP2-dependent p19(Arf) degradation under nutrient-rich conditions."
< "Q5SRY7-1","RefSeq","NP_001258276.1","18782782","Data show that beta-TrCP2 and beta-TrCP1 target PER2 protein in vitro, and also show that the beta-TrCP binding site of PER2 is recognized by both beta-TrCP1 and beta-TrCP2 [beta-TrCP2]."
14727a19778,19782
> "Q8BJQ9-1","RefSeq","NP_766341.4","29287114","Propose that both t1 and t2 are necessary for CS synthesis and normal chondrocyte differentiation but are not sufficient for all CS synthesis in cartilage Publication Status: Online-Only"
> "Q8BJQ9-1","RefSeq","NP_766341.4","28982363","CSGalNAcT1 is important for plasticity, probably due to regulation of chondroitin sulfate-dependent perineuronal nets. Publication Status: Online-Only"
> "Q8BJQ9-1","RefSeq","NP_766341.4","28974755","Here, we show that initiation of ocular dominance plasticity was impaired with reduced CS, using mice lacking a key CS-synthesizing enzyme, CSGalNAcT1. Two-photon in vivo imaging showed a weaker visual response of PV-cells with reduced CS compared to wild-type mice. Plasticity onset was restored by a homeoprotein Otx2, which binds the major CS-proteoglycan aggrecan and promotes its further expression. Publication Status: Online-Only"
> "Q8BJQ9-1","RefSeq","NP_766341.4","21148564","CSGalNAcT-1 is necessary for normal levels of endochondral ossification, and the decrease in CS amount in the growth plate by its absence causes a rapid catabolism of aggrecan."
> "Q8BJQ9-1","RefSeq","NP_766341.4","20812917","Results suggest that CSGalNAcT1 is required for normal CS production in developing cartilage."
14742,14746d19796
< "Q9JIM1-1","RefSeq","NP_001186042.1","30408123","Aortas from Slc29a1-null mice respond to hypoxic insult in a manner comparable to wild-type tissues that have been pharmacologically preconditioned with adenosine. The data also support a role for ENT1 in the regulation of the protective effects of adenosine on contractile function in elastic conduit arteries such as thoracic aorta. Publication Status: Online-Only"
< "Q9JIM1-1","RefSeq","NP_001186042.1","29804297","The results of this study suggested that binge alcohol consumption-induced down-regulation of ENT1 expression may disrupt sleep homeostasis and cause sleep disturbances"
< "Q9JIM1-1","RefSeq","NP_001186042.1","28240653","Calcification of spinal connective tissues in the ENT1 deficient mouse results in a stiffened spine."
< "Q9JIM1-1","RefSeq","NP_001186042.1","28069792","Chronic inhibition of ENT1 or by genetic removal of ENT1 enhanced the survival of R6/2 mice. Collectively, adenosine homeostasis and ENT1 expression are altered in Huntington's disease (HD). The inhibition of ENT1 can enhance extracellular adenosine level and be a potential therapeutic approach for treating HD."
< "Q9JIM1-1","RefSeq","NP_001186042.1","12062437","PKC delta/epsilon-dependent stimulation of hENT1 transport by a mechanism that may involve activation of transporters at the membrane possibly by post-translational modification of the protein."
14755a19806,19810
> "Q80TP3-1","RefSeq","NP_001106192.1","28330927","Findings unveil UBR5 as a novel and critical regulator of tumor growth, metastasis, and immune response in triple negative breast cancer."
> "Q80TP3-1","RefSeq","NP_001106192.1","27299863","Hence, while loss of UBR5 perturbed Hedgehog signalling in the developing limb, there were no obvious morphological defects. Publication Status: Online-Only"
> "Q80TP3-1","RefSeq","NP_001106192.1","25092319","UBR5-mediated ATMIN ubiquitination is a vital event for ATM pathway selection and activation in response to DNA damage"
> "Q80TP3-1","RefSeq","NP_001106192.1","23326633","Silencing Edd1 with shRNA in mouse embryonic stem cells significantly suppressed their growth."
> "Q80TP3-1","RefSeq","NP_001106192.1","15282321","Results suggest that Edd has an essential role in extraembryonic development."
14757a19813,19817
> "P48025-1","RefSeq","NP_035648.2","30611000","Our findings allude to the involvement of SYK in the regulation of innate immune cells such as gammadelta T cells and neutrophils in the context of acute lung injury (ALI) for the first time. Further, our study shows that SYK inhibitor, R406 enhances the survival rate of mice with ALI probably by controlling overtly aggressive innate immune cells through downregulation of inflammatory cytokines and oxidative stress."
> "P48025-1","RefSeq","NP_035648.2","30599182","Study proposes that Syk signaling in DCs and neutrophils plays a critical role during sepsis-induced acute kidney injury (AKI). Therefore, Syk inhibition in innate immune cells might serve as an effective strategy to limit inflammatory cascade during AKI."
> "P48025-1","RefSeq","NP_035648.2","30709742","Mice deficient in macrophage C-type lectin protein (Mincle) or with selective depletion of tyrosine-protein kinase SYK (Syk) had increased systemic translocation of gut microbiota."
> "P48025-1","RefSeq","NP_035648.2","30446225","These results suggested that the Syk/JNK signaling pathway may play a vital role in the inflammasome activation and modulate host immune responses against S. pneumoniae."
> "P48025-1","RefSeq","NP_035648.2","30231985","This study shows that SYK-CARD9 signaling promotes gut Fungi-mediated inflammasome activation to restrict colitis and colon cancer"
14760a19821,19828
> "Q9WTI7-1","RefSeq","NP_032685.1","27156719","Myo1c ensembles can generate forces parallel to lipid bilayers. Publication Status: Online-Only"
> "Q9WTI7-1","RefSeq","NP_032685.1","26044184","We propose a novel genome-wide mechanism where myosin synergizes with Pol II-associated actin to link the polymerase machinery with permissive chromatin for transcription activation. Publication Status: Online-Only"
> "Q9WTI7-1","RefSeq","NP_032685.1","25437912","Ca(2+) binding to calmodulin induces major conformational changes in both IQ motifs and the post-IQ domain and increases flexibility of the myosin-1c tail."
> "Q9WTI7-1","RefSeq","NP_032685.1","25259793","Our observations demonstrate specific changes in the expression of myosin IC isoform A that are concurrent with the occurrence of prostate cancer in the TRAMP mouse prostate cancer model that closely mimics clinical prostate cancer Publication Status: Online-Only"
> "P35436-1","RefSeq","NP_032196.2","30296532","Immune challenge in GluN2A knockout mice resulted in unchanged PSA-NCAM levels and proBDNF increase in both brain structures as well as in increase in BDNF levels in hippocampus. Absence of GluN2A resulted in increased levels of all NCAM isoforms in prefrontal cortex upon lipopolysaccharide which was followed with a decrease in GluN1 and GluN2B subunits. GluN2 A subunit is critical in neuroinflammation-related depression."
> "O54965-1","RefSeq","NP_036013.1","26197965","Host RNF13 affects the concentration of GM-CSF in tumor-bearing lungs"
> "O54965-1","RefSeq","NP_036013.1","24563216","These results indicate that RNF13 deficiency promotes skeletal muscle regeneration via the effects on satellite cell niche mediated by IL-4 and IL-6."
> "O54965-1","RefSeq","NP_036013.1","22890573","RNF13 is involved in the regulation of the SNARE complex, which thereby controls synaptic function."
14763,14768d19830
< "Q8R317-1","RefSeq","NP_081118.4","31059032","The results of this study revealed that hypoxia-ischemic decreased the expression of Ubqln, thus may provide a novel understanding of role of Ubqln in neonatal hypoxic ischemic encephalopathy."
< "Q8R317-1","RefSeq","NP_081118.4","27928652","Post-ischemic overexpression of Ubqln1 significantly promoted functional recovery."
< "Q8R317-1","RefSeq","NP_081118.4","28420763","Reduced body weight gain in mice, overexpressing Ubqln1 was associated with upregulation of SIRT1 and AMPK."
< "Q8R317-1","RefSeq","NP_081118.4","28598849","This study provide strong evidence showing that Ubqln1 plays a crucial role in modulating learning and memory function in different cohorts of transgenic mice."
< "Q8R317-1","RefSeq","NP_081118.4","19148225","UBQLN1-transfected cells did not show increased starvation-induced cell death"
< "Q8R317-1","RefSeq","NP_081118.4","15004330","Described results suggest that ubiquilin proteins play an important role in regulating presenilin 2 (PS2) protein levels in cells."
14772a19835,19839
> "Q9ES89-1","RefSeq","NP_067363.3","29305908","Data show that exostosin-like 2 (EXTL2) controls fibroblast growth factor 2 (FGF2) signaling through regulation of heparan sulfate biosynthesis."
> "Q9ES89-1","RefSeq","NP_067363.3","24176719","EXTL2 controls liver regeneration and aortic calcification through xylose kinase-dependent regulation of glycosaminoglycan biosynthesis.[review] Review article"
> "Q9ES89-1","RefSeq","NP_067363.3","23734945","EXTL2-mediated regulation of glycosaminoglycans synthesis is important for tissue regeneration processes following liver injury."
> "Q9ES89-1","RefSeq","NP_067363.3","23395820","EXTL2 functions to suppress GAG biosynthesis that is enhanced by a xylose kinase and the EXTL2-dependent mechanism that regulates GAG biosynthesis might be a 'quality control system' for proteoglycans"
> "Q9ES89-1","RefSeq","NP_067363.3","12562774","Crystal structure of EXTL2"
14774a19842
> "Q7TPB0-1","RefSeq","NP_859009.2","27744421","PRG3 emerges as a developmental RasGRF1-dependent conductor of filopodia formation and axonal growth enhancer. PRG3-induced neurites resist brain injury-associated outgrowth inhibitors and contribute to functional recovery after spinal cord lesions."
14779a19848,19852
> "Q99M04-1","RefSeq","NP_077791.1","22658261","Decreased endogenous lipoic acid gene expression plays a role in development of diabetic atherosclerosis in ApoE deficient mice."
> "Q99M04-1","RefSeq","NP_077791.1","22021711","Deficiency increases oxidative stress and accelerates the development of diabetic nephropathy"
> "Q99M04-1","RefSeq","NP_077791.1","20347443","Lias deficiency enhances atherosclerosis in male mice, at least in part due to reduced antioxidant capacity"
> "Q99M04-1","RefSeq","NP_077791.1","18845616","Enhanced neutrophil sequestration in the livers of Lias+/- mice was associated with increased hepatocyte injury and increased gene expression of growth-related oncogene, E-selectin, and VCAM-1 in the liver and/or lung."
> "Q99M04-1","RefSeq","NP_077791.1","16135825","Development of homozygous embryos lacking Lias is retarded."
14782,14787d19854
< "Q925T6-1","RefSeq","NP_083012.1","29170386","GRIP1 is phosphorylated at an N-terminal serine cluster by cyclin-dependent kinase-9 (CDK9), which is recruited into GC-induced GR:GRIP1:CDK9 hetero-complexes, producing distinct GRE-specific GRIP1 phospho-isoforms. Publication Status: Online-Only"
< "Q925T6-1","RefSeq","NP_083012.1","28978486","GRIP1 binds to apoER2 and EphrinB2 to induce activity-dependent AMPA receptor insertion at the synapse."
< "Q925T6-1","RefSeq","NP_083012.1","28063882","Study performed social behavioral testing on neuron-specific Grip1/2-double knockout (DKO) and wild type (WT) mice and determined the expression profile of key signaling proteins in AMPAR, mGluR, mTOR, and GABA pathways in brain. Data Grip1/2-mediated AMPA signaling in regulating social behaviors and disturbance of glutamate- and GABA-signaling in specialized brain regions in autism-related social behavioral deficits."
< "Q925T6-1","RefSeq","NP_083012.1","27941904","Data suggest that molecules in the erythropoietin-producing hepatocellular receptor B family (EPHB) / ephrinB (EFNB) signalling pathways, specifically ephrin B3 and GRIP1, are involved blood pressure regulation. Publication Status: Online-Only"
< "Q925T6-1","RefSeq","NP_083012.1","15507123","Investigated whether there is a link between growth inhibitory effect and transcriptional activation of PPARgamma in several gastrointestinal tumour cell lines [GRIP1tau]"
< "Q925T6-1","RefSeq","NP_083012.1","11983858","GRIP1 scaffolding protein is required for the formation and integrity of the dermo-epidermal junction and reveal the importance of PDZ domains in the organization of supramolecular structures essential for mammalian embryonic development."
14791,14802c19858,19862
< "Q8C9B9-1","RefSeq","NP_780760.2","28330622","Embryonic stem cells mainly express DIDO3 and their differentiation after leukemia inhibitory factor withdrawal requires DIDO1 expression. DIDO3 regulates DIDO1 expression."
< "Q8C9B9-1","RefSeq","NP_780760.2","25825751","Data indicate that death inducer-obliterator (dido) mutant mice with high incidence of perinatal lethality and distinct neurodevelopmental, morphogenetic, and metabolic alterations."
< "Q8C9B9-1","RefSeq","NP_780760.2","24667272","Death inducer obliterator (Dido3)-dependent targeting of histone deacetylase 6 (HDAC6) is a key determinant of cilium size in growth-arrested cells Publication Status: Online-Only"
< "Q8C9B9-1","RefSeq","NP_780760.2","24347171","Dido1 is able to regulate self-renewal of mouse embryonic stem cells."
< "Q8C9B9-1","RefSeq","NP_780760.2","19557426","Results indicate that histone H3 lysine 4 demethylation modulates DIDO3 localization in meiosis and suggest epigenetic regulation of the synaptonemal complex"
< "Q8C9B9-1","RefSeq","NP_780760.2","17299043","Dido3, the largest splice variant of the Dido gene, is a centrosome-associated protein whose disruption leads to supernumerary centrosomes, failure to maintain cellular mitotic arrest, and early degradation of the mitotic checkpoint protein BubR1."
< "Q8C9B9-1","RefSeq","NP_780760.2","16127461","Data suggest that Dido might be one of the tumor suppressor genes at chromosome 20q and that the Dido-targeted mouse may be a suitable model for studying myeloproliferative diseases and myelodysplastic syndromes."
< "Q61584-1","RefSeq","NP_001106659.1","30803859","FXR deficiency increased hepatic steatosis and altered bile acid pool composition, contributing to worsened liver toxicity."
< "Q61584-1","RefSeq","NP_001106659.1","30770808","Data show that recessive mutations in the particular exon of RNA binding proteins (FXR1P; FXR1) cause congenital multi-minicore myopathy in humans and mice. Publication Status: Online-Only"
< "Q61584-1","RefSeq","NP_001106659.1","30397356","GUDCA was further identified as an intestinal FXR antagonist that improved various metabolic endpoints in mice with established obesity. Thus, we conclude that metformin acts in part through a B. fragilis-GUDCA-intestinal FXR axis to improve metabolic dysfunction, including hyperglycemia"
< "Q61584-1","RefSeq","NP_001106659.1","29730159","FXR deficiency in hepatocytes might only play a minor role in alcoholic liver diseases (ALD) development. Deficiency of FXR in other non-hepatic tissues and/or increased bile acid levels resultant from whole-body FXR deficiency might be responsible for more severe ALD development."
< "Q61584-1","RefSeq","NP_001106659.1","11178106","Four FXR1 isoforms of molecular weight 70, 74, 78, 80 kDa are widely distributed in mouse organs, while in striated muscles these isoforms are replaced by proteins of 82 and 84 kDa containing an extra pocket of 27 amino acids."
---
> "Q9JI58-1","RefSeq","NP_064414.1","29757143","The authors find that a soluble factor produced by tumor cells is responsible for macrophage RAE-1delta induction, and they identify tumor-derived colony-stimulating factor-1 (CSF-1) as necessary and sufficient for macrophage RAE-1delta induction in vitro and in vivo. Publication Status: Online-Only"
> "Q9JI58-1","RefSeq","NP_064414.1","27444966","Study reports that retinoic acid early induced transcript-1-d and retinoic acid early induced transcript-1-e (Raet1) genes are induced early upon experimental autoimmune encephalomyelitis onset and reach a maximal expression at the peak of the pathology. Study also shows that macrophages as well as microglia, are cellular sources of Raet1 transcripts."
> "O70460-1","RefSeq","NP_036018.1","29391257","CCL19-expressing fibroblastic stromal cells in murine lung carcinoma control tumor growth"
> "O70460-1","RefSeq","NP_036018.1","29505028","We engineered CAR-T cells to express interleukin (IL)-7 and CCL19 (7 x 19 CAR-T cells), as these factors are essential for the maintenance of T-cell zones in lymphoid organs... Following treatment of mice with 7 x 19 CAR-T cells, both recipient conventional T cells and administered CAR-T cells generated memory responses against tumors."
> "O70460-1","RefSeq","NP_036018.1","28807994","A comprehensive model of CCL19 and CCL21 transport and gradient formation in the lymph nodes (LNs) was built; predicts that ACKR4 in LNs prevents CCL19/CCL21 accumulation in efferent lymph, but does not control intranodal gradients; instead, it attributes the disrupted interfollicular CCL21 gradients observed in Ackr4-deficient LNs to ACKR4 loss upstream"
14805a19866,19867
> "P97946-1","RefSeq","NP_034346.1","30354205","VEGF-D, a powerful lymphangiogenic and angiogenic growth factor, is also a major regulator of chylomicron metabolism in mice."
> "P97946-1","RefSeq","NP_034346.1","29632070","Results identify HDAC4 as an epigenetic regulator of neuronal morphology that controls dendritic arborization via the expression of VEGFD"
14816a19879,19881
> "Q8C6K9-1","RefSeq","NP_766515.2","21477648","Immunoelectron microscopy of skeletal muscle localized the collagen VI alpha 6 chain to the reticular lamina of muscle fibers"
> "Q8C6K9-1","RefSeq","NP_766515.2","18400749","Discovery of three additional collagen VI chains doubles the collagen VI family and adds a layer of complexity to collagen VI assembly and function in the extracellular matrix"
> "Q8C6K9-1","RefSeq","NP_766515.2","18276594","Analysis of collagen VI chains alpha4, alpha5, and alpha6with high homology to the alpha3 chain"
14825d19889
< "Q9JHH2-1","RefSeq","NP_001121552.1","29178985","Study demonstrates a complementary role between TSSC6 and P2Y12 receptor in platelets in regulating 'outside in' integrin alphaIIbbeta3 signalling thrombus growth and stability."
14826a19891,19893
> "O35149-1","RefSeq","NP_035904.2","26538236","Loss of ZnT4 has profound consequences on mammary epithelial cell secretion and may promote tissue remodeling in the mammary gland during early lactation."
> "O35149-1","RefSeq","NP_035904.2","22621784","It was shown that that ZnT4 transports Zn into the trans-Golgi network, which is critical for key secretory functions of the mammary cell."
> "O35149-1","RefSeq","NP_035904.2","15257151","Expression of zinc transporter ZnT4 in mouse choroid epithelial cells suggests that the choroid plexus plays an important role in regulation of zinc homeostasis in the brain."
14837,14840c19904,19906
< "Q63994-1","RefSeq","NP_001104528.1","25320078","Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs."
< "Q63994-1","RefSeq","NP_001104528.1","24227736","CD33-related Siglec-E recognizes the intact neuron and has neuroprotective function by preventing phagocytosis."
< "Q63994-1","RefSeq","NP_001104528.1","17008544","SOCS3 inhibited the CD33-induced block on cytokine-induced proliferation. SOCS3 and its target protein CD33 are degraded concomitantly concomitantly."
< "Q63994-1","RefSeq","NP_001104528.1","12773563","MCD33 is expressed on myeloid precursors in the bone marrow"
---
> "Q04998-1","RefSeq","NP_032406.1","30074079","Our data indicate that VWC2, a bone matrix-associated secretory protein, enhances cranial bone formation through inhibiting Activin signaling and activin-induced cell functions via direct binding to activin A"
> "Q04998-1","RefSeq","NP_032406.1","30093305","The observed reduction of the infarct volume was comparable to the protection obtained by intracerebroventricular injection of recombinant Activin A or SerpinB2 or by stereotactic delivery 3 weeks prior to the injury of a recombinant adeno-associated virus containing an expression cassette for the potent neuroprotective transcription factor Npas4"
> "Q8CHZ9-1","RefSeq","NP_742147.1","23562081","MTERF1 does not regulate heavy-strand transcription, but rather acts to block transcription on the opposite strand of mtDNA to prevent transcription interference at the light-strand promoter."
14847a19914,19918
> "O88552-1","RefSeq","NP_057884.1","28939759","Results reveal that IL-22 increases intestinal epithelial permeability by upregulating Claudin-2 expression through the JAK/STAT pathway"
> "O88552-1","RefSeq","NP_057884.1","28605031","The tight junction patch clamp technique indicated mouse claudin-2 ion channel opening events in MDCK cells"
> "O88552-1","RefSeq","NP_057884.1","27214555","Claudin-2-null mice conserve sodium to the same extent as WT mice, even during profound dietary sodium depletion, as a result of the upregulation of transcellular Na-K-2Cl transport activity in the thick ascending limb of Henle"
> "Q9ERS5-1","RefSeq","NP_112547.1","27859053","This study shows that TAPP1/2 double knock-out mice develop chronic germinal centers with age and show abnormal expression of B-cell activation and develop lupus-like characteristics including anti-DNA antibodies and deposition of immune complexes in kidneys"
> "Q9ERS5-1","RefSeq","NP_112547.1","22777911","Interacts with phosphatidylinositol (3,4)-bisphosphate thus regulating B-cell activation and autoantibody production"
14852a19924
> "Q62432-1","RefSeq","NP_034884.2","30651315","Our findings generate a mouse model to study the roles of SMAD2/3 in the uterus and serve to provide insight into the mechanism by which the endometrium can escape the plethora of growth regulatory proteins"
14854a19927,19928
> "O70584-1","RefSeq","NP_032727.2","25919494","That Nkx2.2 and Nkx2.9 proteins play no role in the development of branchiovisceral motor neurons in hindbrain rostral to rhombomere 4. Publication Status: Online-Only"
> "O70584-1","RefSeq","NP_032727.2","22399681","Nkx2.9 controls SACMN axon exit from the mammalian spinal cord by regulating Robo-Slit signaling"
14866a19941,19943
> "P48168-1","RefSeq","NP_034428.2","25955356","A species-specific thymine-to-guanine sequence variation in the Glrb gene has been identified which gives rise to species-specific splice donor sites in the Glrb genes of mouse and bushbaby. Publication Status: Online-Only"
> "P48168-1","RefSeq","NP_034428.2","24509844","The SdpI-binding site was mapped to a proline-rich sequence of 22 amino acids within the intracellular loop of GlyRbeta."
> "P48168-1","RefSeq","NP_034428.2","17145751","Transcripts are detected in cerebral cortex, liver, and heart. Lack of exon 7 results in a profoundly altered prediction of transmembrane topology."
14871a19949,19952
> "E9Q7G0-1","RefSeq","NP_598708.3","28469279","It has been reported that the Galectin-3/NuMA interaction is functionally important for the spindle pole organization; spindle pole cohesion requires glycosylation-mediated localization of NuMA. Publication Status: Online-Only"
> "E9Q7G0-1","RefSeq","NP_598708.3","28079116","SiRNA-mediated depletion of NuMA induced abnormal mitotic phenotypes in cultured mouse embryonic fibroblasts and aberrant neurogenesis and neuronal migration in the mouse embryonic brain Publication Status: Online-Only"
> "E9Q7G0-1","RefSeq","NP_598708.3","26765568","These results reveal an additional and direct function of NuMA during mitotic spindle positioning, as well as a reiterative use of spindle orientation in the skin to build diverse structures. Publication Status: Online-Only"
> "E9Q7G0-1","RefSeq","NP_598708.3","26766442","Suppressor APC domain containing 2 negatively regulates the localization of LGN at the cell cortex, likely by competing with NuMA for its binding"
14874a19956
> "Q8VDT1-1","RefSeq","NP_663526.3","15607332","SGLT4 would have unique physiological functions (i.e., absorption and/or reabsorption of Man, 1,5AG, and Fru, in addition to Glc). Erratum:[Life Sci. 2010 Oct 9;87(15-16):514]"
14876a19959,19969
> "Q80TR8-1","RefSeq","NP_001015507.1","29925675","The basis for RAG1 turnover and provide evidence that the CRL4(VprBP(DCAF1)) complex functions to maintain physiological levels of V(D)J recombination."
> "Q80TR8-1","RefSeq","NP_001015507.1","26728942","DCAF1 is required for T-cell expansion and function during anti-viral and autoimmune responses. Publication Status: Online-Only"
> "Q80TR8-1","RefSeq","NP_001015507.1","26150531","VprBP Is Required for Efficient Editing and Selection of Igkappa+ B Cells, but Is Dispensable for Iglambda+ and Marginal Zone B Cell Maturation and Selection"
> "Q80TR8-1","RefSeq","NP_001015507.1","24357321","CRL4(VPRBP) ubiquitin ligase is a guardian of female reproductive life in germ cells and a maternal reprogramming factor after fertilization. Erratum:[Science. 2014 May 2;344(6183):370]"
> "Q80TR8-1","RefSeq","NP_001015507.1","22157821","Multi-subunit cullin RING E3 ligase complex VprBP/DDB1/Cul4A/Roc1 associates with full-length RAG1 through VprBP"
> "Q80TR8-1","RefSeq","NP_001015507.1","18606781","Data show that human immunodeficiency virus type 1 Vpr-binding protein VprBP binds stoichiometrically with DDB1 through its WD40 domain and through DDB1 to CUL4A, subunits of the COP9/signalsome."
> "Q8C4Y3-1","RefSeq","NP_067368.3","30036938","BRCA1 Interacting Protein COBRA1 Facilitates Adaptation to Castrate-Resistant Growth Conditions. Publication Status: Online-Only"
> "Q8C4Y3-1","RefSeq","NP_067368.3","26010750","Both human and mouse NELF-B proteins are translated from a non-AUG codon upstream of the annotated AUG. GeneRIF: Human and mouse Nelfb encode proteins translated from a non-AUG (CUG) start codon. The majority of mouse tissues examined express the isoform translated from the CUG start codon, but a small number of tissues also express a shorter isoform of the same apparent size as the AUG-initiated isoform. Publication Status: Online-Only"
> "Q8C4Y3-1","RefSeq","NP_067368.3","24034695","Cobra1 Is Required for TrkC-Induced Apoptosis."
> "Q8C4Y3-1","RefSeq","NP_067368.3","21865163","Genetic and genomic studies provide new physiological and molecular insight into Nelf-mediated pol II pausing."
> "Q8C4Y3-1","RefSeq","NP_067368.3","19340312","Findings also indicate that Cobra1 helps maintain the undifferentiated state of mESCs by preventing unscheduled expression of developmental genes"
14886,14887d19978
< "Q9CY57-1","RefSeq","NP_001280705.1","20688955","The recently identified chromatin factor Friend of Prmt1 (FOP) is a critical modulator of gamma-globin gene expression."
< "Q9CY57-1","RefSeq","NP_001280705.1","19858291","Fop is tightly associated with chromatin, and that it is modified by both asymmetric and symmetric arginine methylation in vivo. Fop plays an important role in the ligand-dependent activation of estrogen receptor target genes, including TFF1 (pS2)."
14891a19983,19984
> "Q8BH60-1","RefSeq","NP_444417.2","20958966","PIST protein, mouse plays an important role in regulating the intracellular sorting/ localization of cadherin 23. Publication Status: Online-Only"
> "Q8BH60-1","RefSeq","NP_444417.2","12149515","Predominantly localized at the trans-Golgi region in round spermatids; male mice in which GOPC has been disrupted are infertile with globozoospermia"
14898a19992
> "Q7TRK1-1","RefSeq","NP_001005485.1","29984401","Olfr110/111 and Olfr544 proteins are mainly expressed by neurons in cortical and hippocampal regions and, to a lesser extent, by glia and endothelial cells. expression of the mRNA encoding for Olfr110/111 tends to increase with age in both the cortex and hippocampus of wild-type and transgenic mice. Moreover, Olfr110/111 transcript expression is markedly impaired in the brain of Alzheimer's disease-like mice."
14900,14905c19994
< "Q9EST8-1","RefSeq","NP_001152866.1","30224457","Results uncover an important role for IkappaBzeta in IL-36 signaling and validate IkappaBzeta as an attractive target for psoriasis therapy."
< "Q9EST8-1","RefSeq","NP_001152866.1","29934320","PDLIM2, known as the ubiquitin E3 ligase, participates in NQO1-dependent IkappaB-zeta degradation."
< "Q9EST8-1","RefSeq","NP_001152866.1","29670287","Electrophilic properties of itaconate and derivatives regulate the IkappaBzeta-ATF3 inflammatory axis; results demonstrate that targeting the DI-IkappaBzeta regulatory axis could be an important new strategy for the treatment of IL-17-IkappaBzeta-mediated autoimmune diseases"
< "Q9EST8-1","RefSeq","NP_001152866.1","28740238","Results suggest that the Nfkbiz gene has a potential regulatory role in the microbiota-skin immunity axis. Publication Status: Online-Only"
< "Q9EST8-1","RefSeq","NP_001152866.1","28391993","In cultured macrophages, LPS-induced expression of monocyte chemoattractant protein (MCP)-1 was suppressed by NaN3 through inhibition of STAT1 and IkappaBzeta activities."
< "Q9EST8-1","RefSeq","NP_001152866.1","11086164","MAIL localizes in the nucleus, and accelerates IL-6 production by LPS stimulation in mouse fibroblasts."
---
> "Q61224-1","RefSeq","NP_032335.2","27156838","These results suggest that the activation of 5-HT1D receptors selectively enhanced IA via the Gbetagamma of the Go-protein, PKA, and the sequential B-Raf-dependent p38 MAPK signaling cascade."
14907a19997,19999
> "P97449-1","RefSeq","NP_032512.2","28859152","We concluded that APN plays a significant role in the regulation of several sperm functions and early embryonic development. In addition, increased APN activity could potentially lead to several adverse consequences related to male fertility. Publication Status: Online-Only"
> "P97449-1","RefSeq","NP_032512.2","26936360","These studies identified CD13 as a novel negative regulator of mast cell activation in vitro and in vivo."
> "P49442-1","RefSeq","NP_032410.2","11932254","Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor."
14914a20007,20008
> "Q6PFD5-1","RefSeq","NP_941020.1","30688005","SAPAP3 mutation in the mouse model of obsessive-compulsive disorder impairs Pavlovian reversal learning."
> "Q6PFD5-1","RefSeq","NP_941020.1","29035974","Recorded ultrasonic vocalizations (USVs) from 5-day-old sapap3 and sapap3 mice, and also monitored developmental reflexes in these mice during the early postnatal period. Sapap3 mice display an increase in the number and duration of USV calls relative to sapap3 littermates, despite otherwise similar developmental profiles."
14916,14917c20010,20012
< "Q8C5L3-1","RefSeq","NP_001032935.2","24200330","These data have uncovered a novel role of core components of the Ccr4-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells."
< "Q8C5L3-1","RefSeq","NP_001032935.2","22367759","Cnot1, Cnot2, and Cnot3 represent a novel component of the core self-renewal and pluripotency circuitry conserved in mouse and human ESCs."
---
> "Q62418-1","RefSeq","NP_038838.1","22450813","MAbp1 is of fundamental importance for spreading and migration under shear stress conditions, which are critical prerequisites for efficient PMN extravasation during inflammation."
> "P17047-1","RefSeq","NP_034815.2","30048497","Interruption of LAMP-2 expression did not result in an increase of the steady-state protein levels of DJ-1 /PARK7, as it would have been expected. No change in DJ-1 /PARK7 protein levels were observed upon inhibition of lysosomal function with NH4Cl or NH4Cl plus leupeptin, or after activation of CMA by serum starvation for 24h. Publication Status: Online-Only"
> "P17047-1","RefSeq","NP_034815.2","30068868","Both LAMP-1 and LAMP-2 are involved in C2C12 myotube formation and LAMP-2 may contribute dominantly to it."
14920a20016,20020
> "Q9R1R2-1","RefSeq","NP_061368.1","26527743","Temporal control of gamma-actin levels by TRIM3 is required to regulate the timing of hippocampal plasticity."
> "Q9R1R2-1","RefSeq","NP_061368.1","24393003","The RING domain is required for TRIM3-induced growth suppression."
> "Q9R1R2-1","RefSeq","NP_061368.1","23318451","Data indicate TRIM3 and p21 interact in cells."
> "Q9R1R2-1","RefSeq","NP_061368.1","24086586","TRIM3, also known as BERP, interacts with KIF21B via its RBCC domain. Publication Status: Online-Only"
> "Q9R1R2-1","RefSeq","NP_061368.1","20543135","Brain-expressed RING finger protein (BERP) is a gene whose expression is up-regulated in a p53-dependent manner"
14926a20027,20030
> "Q8BZZ3-1","RefSeq","NP_796301.2","30471861","WWP1 was upregulated in obese white adipose tissue in a p53-dependent manner. To investigate the functions of WWP1 in adipocytes, a proteome analysis of WWP1 overexpression (OE) and knockdown (KD) 3T3-L1 cells was performed. This analysis showed a positive correlation between WWP1 expression and the abundance of several antioxidative proteins."
> "Q8BZZ3-1","RefSeq","NP_796301.2","30392800","Study delineatea a novel regulatory pathway that involves Sox9-[Wwp1/Wwp2/miR-140]-Fyn required for axon specification, acquisition of pyramidal morphology, and proper laminar distribution of cortical neurons."
> "Q8BZZ3-1","RefSeq","NP_796301.2","27107943","Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin. This suggests that the E3 ligase WWP1 is involved in the pathogenesis of Huntington's disease; therefore, it may be a novel target for therapeutic intervention."
> "Q8BZZ3-1","RefSeq","NP_796301.2","26386426","Cardiomyocyte-specific overexpression of Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis."
14929a20034,20039
> "Q0VGM9-1","RefSeq","NP_001160140.1","29290468","Rtel1 binds to and inhibits restart of reversed replication forks within telomeres, which compromises replication and leads to critically short telomeres."
> "Q0VGM9-1","RefSeq","NP_001160140.1","24115439","RTEL1 plays a critical role in both telomere and genome-wide replication, which is crucial for genetic stability and tumor avoidance."
> "Q0VGM9-1","RefSeq","NP_001160140.1","22593209","Propose that mRtel1 is a key protein for DNA replication, recombination, and repair and efficient elongation of telomeres by telomerase"
> "O35136-1","RefSeq","NP_035084.1","26611261","Abeta-dependent disruption of NCAM2 functions in Alzheimer's disease hippocampus contributes to synapse loss. Publication Status: Online-Only"
> "O35136-1","RefSeq","NP_035084.1","25875008","These results indicate that OCAM exerts a posttranscriptional control on the ErbB2 signalling in spinal cord stem cells. This study adds further support for considering cell adhesion molecules as regulators of the ErbB signalling Publication Status: Online-Only"
> "O35136-1","RefSeq","NP_035084.1","25632147","This study identified the cell adhesion molecule NCAM2 as a new regulator of filopodial formation and neurite branching."
14934,14936d20043
< "P38532-1","RefSeq","NP_001318083.1","30316516","The results suggest that HSF1 and NRF2 suppress heme-induced and heat-induced HO-1 expression, respectively."
< "P38532-1","RefSeq","NP_001318083.1","29941492","HSF1 phosphorylation at both Ser303 (S303) and Ser307 (S307) has been shown to repress HSF1 transcriptional activity under normal physiological growth conditions. Our results confirmed that loss of phosphorylation in HSF1(303A/307A) cells and tissues increases protein stability but also markedly sensitizes HSF1 activation under normal and heat- or nutrient-induced stress conditions. Publication Status: Online-Only"
< "P38532-1","RefSeq","NP_001318083.1","24855652","After heat shock, HSF1gamma isoforms are exported from the nucleus more rapidly or degraded more quickly than HSF1alpha or HSF1beta"
14938,14942c20045,20052
< "Q8BWY7-1","RefSeq","NP_001159975.1","23643525","Data suggest that Zip11 has unique protein sequence and structure features, it functions as a cellular zinc transporter, and its expression is at least partially regulated by zinc via hMTF-1 binding to metal response element sequences of Zip11 promoter."
< "Q91ZM2-1","RefSeq","NP_001276467.1","29180441","Brain-specific Sh2b1 knockout (KO) mice exhibited brain growth retardation and reactive aggression."
< "Q91ZM2-1","RefSeq","NP_001276467.1","29631267","The increased expression of genes in leptin (JAK/STAT or AKT) signaling implies that the main mode of action for SH2B1 mutations might affect leptin signaling rather than insulin signaling. Erratum:[Obes Facts. 2018;11(3):176-180. PMID: 29739001]"
< "Q91ZM2-1","RefSeq","NP_001276467.1","27217487","Data identify SH2B1 as a major regulator of IRS2 stability, demonstrate a novel feedback mechanism linking mTORC1 signaling with IRS2, and identify 4E-BP2 as a major regulator of proliferation and survival of beta-cells."
< "Q91ZM2-1","RefSeq","NP_001276467.1","18247337","An essential role of the SH2B1 variants in the activation of the Src kinase and the resulting mitogenic response--extending to phenotypic cell transformation and involving the established Src substrate STAT3"
---
> "Q6SJ95-1","RefSeq","NP_951014.1","19759265","TBP2 binds to promoters of misregulated genes, suggesting that TBP2 directly regulates their expression"
> "Q6SJ95-1","RefSeq","NP_951014.1","18851836","Properties of a TAF3/TRF3 complex in directing transcription initiation at the Myogenin promoter"
> "Q6SJ95-1","RefSeq","NP_951014.1","16721357","Data suggest that TRF3 plays a role in early mouse development, and may also be involved in Pol I transcription."
> "Q6SJ95-1","RefSeq","NP_951014.1","14634207","TRF3 is a nuclear protein that is present in all human and mouse tissues and cell lines examined"
> "Q8C7R7-1","RefSeq","NP_796280.1","30509498","Rfx6 can directly bind to upstream of MiR-145, MiR-195, and possibly other non-protein-coding functional RNAs to control adult mouse pancreatic differentiation. Interestingly, our study revealed that Rfx6 played an important role in insulin translation by binding to the Eif2ak1, Upf1, and Eif5."
> "Q8C7R7-1","RefSeq","NP_796280.1","25497096","Rfx6 loss in adult beta cells leads to glucose intolerance, impaired beta cell glucose sensing, and defective insulin secretion."
> "Q8C7R7-1","RefSeq","NP_796280.1","20148032","Studies demonstrate a unique position for Rfx6 in the hierarchy of factors that coordinate pancreatic islet development in both mice and humans"
> "Q8C7R7-1","RefSeq","NP_796280.1","20040487","Rfx6 is found in postmitotic islet progenitor cells in the embryo and is maintained in all developing and adult islet cell types. It is dependent on Ngn3 and during islet cell differentiation."
14949d20058
< "Q9Z2Y3-1","RefSeq","NP_671705.2","12176012","Molecular cloning of Homer1d, an alternativly splice isoform, that controls trafficking of group I metabotropic glutamate receptor"
14950a20060,20063
> "Q922Z0-1","RefSeq","NP_081718.2","27858532","In this framework, an epiallele is defined as a specific combination of methylated CpG within Ddo locus and can represent the epigenetic haplotype revealing a cell-to-cell methylation heterogeneity."
> "Q922Z0-1","RefSeq","NP_081718.2","26961959","This study demonstraed that age-related reduction of free d-Asp levels in the mouse brain in dod knockout mice."
> "Q922Z0-1","RefSeq","NP_081718.2","25689573","Ddo(-/-) mice display a significant reduction in schizophrenia related symptoms induced by phencyclidine. Increased D-aspartate in Ddo(-/-) animals affect the development of cortico-hippocampal connectivity networks potentially involved in schizophrenia. Publication Status: Online-Only"
> "Q922Z0-1","RefSeq","NP_081718.2","16725213","Reports that the behavioral phenotype of the Dco-/- mouse is characterized by deficits in prepulse inhibition of the acoustic startle reflex and in motor coordination on the RotoRod"
14952a20066,20068
> "Q80V63-1","RefSeq","NP_857633.2","23918801","Results suggest that Prdm4 functions redundantly with other transcriptional partners to cooperatively regulate gene expression in the embryo and adult animal."
> "Q80V63-1","RefSeq","NP_857633.2","23048031","SC1 and PRMT5 are components of an epigenetic regulatory complex that maintains the 'stem-like' cellular state of the neural stem cells."
> "Q9QW08-1","RefSeq","NP_077778.1","24376776","The role of phosducin at the rod-to-rod bipolar cell (RBC) synapse Publication Status: Online-Only"
14956,14959c20072,20076
< "Q8C078-1","RefSeq","NP_001186605.1","31164648","CaMKK2 is highly expressed within intratumoral myeloid cells in mouse models of breast cancer, and demonstrate its inhibition within myeloid cells suppresses tumor growth by increasing intratumoral accumulation of effector CD8(+) T cells and immune-stimulatory myeloid subsets. Tumor-associated macrophages isolated from Camkk2 KO mice expressed higher levels of chemokines involved in the recruitment of effector T cells. Publication Status: Online-Only"
< "Q8C078-1","RefSeq","NP_001186605.1","29314250","The data presented here underscore the therapeutic potential of targeting CaMKK2 to promote efficacious and rapid healing of bone fractures and as a mechanism to strengthen normal bones."
< "Q8C078-1","RefSeq","NP_001186605.1","28981105","We demonstrated that systemic administration of the small molecule CaMKK2 inhibitor, STO-609, to irradiated mice enhanced Hematopoietic stem and progenitor cells (HSPCs)recovery and improved survival. These findings identify CaMKK2 as an important regulator of HSPC regeneration and demonstrate CaMKK2 inhibition is a novel approach to promoting hematopoietic recovery after BM injury. Publication Status: Online-Only"
< "Q8C078-1","RefSeq","NP_001186605.1","14586002","Findings suggest CaM kinase kinase beta isoforms are required for the formation of hippocampal long-term memory[LTM], but not needed for contextual, trace fear, and passive avoidance LTM"
---
> "P0C6A2-1","RefSeq","NP_001074823.2","28629181","MAMLD1 contributes to the maintenance of postnatal testicular growth and daily sperm production but is dispensable for androgen biosynthesis and fertility. Publication Status: Online-Only"
> "P0C6A2-1","RefSeq","NP_001074823.2","26435405","MAMLD1 likely participates in functional luteolysis by regulating Stat5b and other genes, independent of the PGF2alpha signaling pathway. Publication Status: Online-Only"
> "P0C6A2-1","RefSeq","NP_001074823.2","23087174","Mamld1 deficiency significantly reduces mRNA expression levels of multiple genes expressed in mouse fetal Leydig cells but permits normal genital and reproductive development"
> "P0C6A2-1","RefSeq","NP_001074823.2","21559465","Mamld1 enhances Cyp17a1 expression primarily in Leydig cells and permit to produce a sufficient amount of testosterone for male sex development, independently of the Hes3-related non-canonical Notch signaling Publication Status: Online-Only"
> "P0C6A2-1","RefSeq","NP_001074823.2","18162467","CXorf6 transactivates the Hes3 promoter, augments testosterone production"
14970a20088,20096
> "Q8BR86-1","RefSeq","NP_080600.1","29362445","Findings provide evidence that Kirrel3(-/-) mice exhibit autistic-like behaviors, including social and communicative deficits, repetitive behaviors, and sensory abnormalities, as well as hyperactivity. Publication Status: Online-Only"
> "Q8BR86-1","RefSeq","NP_080600.1","28815295","The results of this study demonstrate that Kirrel2 and Kirrel3 are essential for the formation of glomeruli and suggest they contribute to synaptogenesis in the accessory olfactory bulb."
> "Q8BR86-1","RefSeq","NP_080600.1","28670619","This study demonstrated that selective loss of mossy fiber filopodial synapses with GABA neurons likely underlies the hippocampal activity imbalance observed in Kirrel3 knockout mice and may impact neural function in patients with Kirrel3-dependent neurodevelopmental disorders. Publication Status: Online-Only"
> "Q8BR86-1","RefSeq","NP_080600.1","28621431","Mouse Kirrel3 is a myobast adhesion molecule which promotes the morphological change of rounded MPC to a spindle shaped myocyte that migrates in a directed fashion and participates in the tight interactions between myocytes prior to their fusion"
> "Q8BR86-1","RefSeq","NP_080600.1","18752272","Results suggest that Kirrel3 plays a role in the axonal pathfinding, cell recognition, and synapse formation of DRG neurons on target cells, including the targeting of proprioceptive neurons on muscle spindles through the interaction with nephrin."
> "Q8BR86-1","RefSeq","NP_080600.1","18022324","These results suggest that mKirre may be involved in the establishment of the pathway from sensory organs to the brain."
> "Q8BR86-1","RefSeq","NP_080600.1","16874800","In the adult brain, Neph2 is seen in the olfactory nerve layer and the glomerular layer of the olfactory bulb, in the hippocampus, and in cerebellar Purkinje cells. At the ultrastructural level, Neph2 is seen in dendritic shafts of pyramidal neurons."
> "Q8BR86-1","RefSeq","NP_080600.1","15908127","The spatiotemporal expression pattern of mKirre mRNA suggests important roles of mKirre in later developmental processes, especially the synapse formation."
> "Q8BR86-1","RefSeq","NP_080600.1","12665856","Involved in the hematopoietic supportive capacity of OP9 mouse stromal cells"
14974a20101,20104
> "P70704-1","RefSeq","NP_033857.1","27287255","In a sociability test, the Atp8a1+ mice displayed no preference for an encaged stranger mouse over a novel object, which is a characteristic autistic-like behavior. In sharp contrast, Atp8a1 (-/-) mice displayed a preference for a stranger mouse over the novel object, which is characteristic of neurotypical mouse behavior."
> "P70704-1","RefSeq","NP_033857.1","22007859","The data of this study strongly indicated that Atp8a1 plays a central role in the PM-APLT activity of some mammalian cells."
> "P70704-1","RefSeq","NP_033857.1","17239457","Such observations suggest tissue-specific differences in transcription initiation complex assembly and regulation of ATPase II gene expression."
> "P70704-1","RefSeq","NP_033857.1","14975727","Role in normal phospholipid distribution in the bilayer, and for normal binding, penetration, and signaling by the zona pellucida"
14975a20106
> "P49718-1","RefSeq","NP_032592.2","27955842","SOX10 directly activates MCM5 transcription by binding to conserved SOX10 consensus DNA sequences in the MCM5 promoter."
14981,14986c20112,20113
< "Q3UTH8-1","RefSeq","NP_001028501.1","30087324","Collybistin binds the GABAAR-alpha2-subunit with high affinity Publication Status: Online-Only"
< "Q3UTH8-1","RefSeq","NP_001028501.1","29069083","Results uncover previously unexpected role for CB isoforms downstream of alpha2-containing GABAARs during neuron maturation in a Cdc42 dependent mechanism. Publication Status: Online-Only"
< "Q3UTH8-1","RefSeq","NP_001028501.1","25082542","Within this network, collybistin can adopt open/active and closed/inactive conformations to act as a switchable adaptor that links gephyrin to plasma membrane phosphoinositides."
< "Q3UTH8-1","RefSeq","NP_001028501.1","19236916","Data provide the first evidence that collybistin deficiency leads to significant changes of GABAergic inhibition, network excitability and synaptic plasticity in vivo."
< "Q3UTH8-1","RefSeq","NP_001028501.1","17690689","Cb is essential for gephyrin-dependent clustering of a specific set of GABA(A) receptors, but not required for glycine receptor postsynaptic localization."
< "Q3UTH8-1","RefSeq","NP_001028501.1","16616186","The resolution crystal structure of the Cdc42-collybistin II complex reveals a novel conformation of the switch I region of Cdc42, and biochemical data indicate that gephyrin negatively regulates collybistin activity."
---
> "Q8VDB2-1","RefSeq","NP_663452.1","23818223","Data indicate that each of the mutations in the GC-rich sequence and YY1-binding element reduced asparagine-linked glycosylation 12 homolog (ALG12 promoter activity, and the combination of these mutations additively decreased reporter activity."
> "Q8VDB2-1","RefSeq","NP_663452.1","21106106","These results show that the mouse CRELD2 and ALG12 genes are arranged as a unique bidirectional gene pair. Publication Status: Online-Only"
14991a20119,20123
> "O70293-1","RefSeq","NP_036068.2","30576947","Findings show that chemerin-activated CMKLR1 regulation in inflammatory macrophages is largely GRK6 and beta-arrestin mediated, which may impact innate immunity and have therapeutic implications in rheumatic disease."
> "O70293-1","RefSeq","NP_036068.2","29969579","These data indicate that GRK2, GRK5 and GRK6 redundantly modulate Smo-GATA crosstalk in fetal mouse hearts, orchestrating transcriptional pathways previously linked to clinical and experimental atrioventricular canal defects"
> "O70293-1","RefSeq","NP_036068.2","28939643","These studies suggest a previously unrecognized and novel role for GRK6 in neutrophil migration specific to pulmonary tissue during bacterial infection."
> "O70293-1","RefSeq","NP_036068.2","28457871","Conditions for optimal dendritic cells guidance are perfectly provided by the CCL21 gradients measured in vivo. Furthermore, CCR7 signal termination by the G-protein-coupled receptor kinase 6 (GRK6) is crucial for haptotactic but dispensable for chemotactic CCL21 gradient sensing in vitro and confirm those observations in vivo."
> "O70293-1","RefSeq","NP_036068.2","12032308","Deficiency causes defective lymphocyte chemotaxis"
14994a20127,20130
> "Q9QXE2-1","RefSeq","NP_064416.1","30763888","DNA polymerases beta and lambda in single-nucleotide and multinucleotide pathways of mammalian base excision DNA repair"
> "Q9QXE2-1","RefSeq","NP_064416.1","26240371","Pol mu and Pol lambda play a key role in conferring on NHEJ the flexibility required for accurate and efficient repair"
> "Q9QXE2-1","RefSeq","NP_064416.1","11937519","Pol lambda is not required for normal Ig gene hypermutation."
> "Q9QXE2-1","RefSeq","NP_064416.1","11909969","Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome."
15012a20149,20158
> "Q9ES64-1","RefSeq","NP_710143.2","29386551","Under normal housing conditions, Ush1g(-/-) and Ush1c(-/-) albino mice have dysfunctional cone photoreceptors whereas pigmented knockout animals have normal photoreceptors. Publication Status: Online-Only"
> "Q9ES64-1","RefSeq","NP_710143.2","12485990","The shaping of the hair bundle relies on a functional unit composed of myosin VIIa, harmonin b and cadherin 23 that is essential to ensure the cohesion of the stereocilia"
> "Q9ES64-1","RefSeq","NP_710143.2","12407180","Forms a complex with cadherin 23 by means of PDZ-domain interactions"
> "Q812A3-1","RefSeq","NP_705722.2","28754631","Results showed expression of myoblast differentiation marker genes were increased by interference and reduced by ANKRD23 overexpression, indicating that ANKRD23 played a negative role in the myoblast differentiation; discovered a long non-coding RNA-AK004293 which was overlapped with the 3'UTR of ANKRD23 gene. Thus, AK004293 had no significant effect on the expression of myoblast differentiation maker genes and ANKRD23."
> "Q812A3-1","RefSeq","NP_705722.2","27889934","Ankrd23(-/-) mice exhibit limited ability to form collateral arteries following femoral artery occlusion compared to WT mice.  Further research will be required to determine whether Ankrd23 plays an important role in mechanically induced vascular remodeling of the arterial tree in skeletal muscle. Review article"
> "Q812A3-1","RefSeq","NP_705722.2","26398569","DARP regulates glucose disposal in skeletal muscle and thus modifies the glucose homeostasis by modulating AMPK activity. Publication Status: Online-Only"
> "Q812A3-1","RefSeq","NP_705722.2","24736439","CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to mechanical pressure overload. Erratum:[PLoS One. 2015;10(3):e0118523. PMID: 25747160] Publication Status: Online-Only"
> "Q812A3-1","RefSeq","NP_705722.2","19028694","Dapr is involved in the PI3K signaling cascade, potentially acting as a scaffold protein for PKB and coordinating its compartmentalization during differentiation."
> "Q812A3-1","RefSeq","NP_705722.2","17392382","DARP plays important structural and gene regulatory roles in skeletal muscle."
> "Q812A3-1","RefSeq","NP_705722.2","12456686","Investigation of potential role in energy metabolism"
15013a20160,20163
> "Q9ESZ8-1","RefSeq","NP_034495.2","31011227","Study provides molecular and cellular evidence for myelination deficits in Williams syndrome linked to neuronal deletion of Gtf2i. Erratum:[Nat Neurosci. 2019 Jul;22(7):1197. PMID: 31171854]"
> "Q9ESZ8-1","RefSeq","NP_034495.2","30120731","Mice with a single copy of Gtf2i (Gtf2i(+/Del)) had increased axonal outgrowth and increased TRPC3-mediated calcium entry upon carbachol stimulation."
> "Q9ESZ8-1","RefSeq","NP_034495.2","29568691","The results suggest a role for GTF2i in the hypersocial phenotype of WBS and more broadly in the regulation of social behavior. Support was not observed for the role of GTF2i in ASD. Publication Status: Online-Only"
> "Q9ESZ8-1","RefSeq","NP_034495.2","27194223","The Cre-mediated deletion of exon 3 recapitulates a genetic null phenotype, indicating that the conditional Gtf2i line is a valuable tool for studying TFII-I function during embryonic development"
15017,15018d20166
< "P63137-1","RefSeq","NP_001334243.1","30013074","These extensive schizophrenia-like and comorbid phenotypes brought about by Gabrb2 knockout, in conjunction with our previous findings on GABRB2 association with schizophrenia, support a pivotal role of GABRB2 in schizophrenia etiology. Publication Status: Online-Only"
< "P63137-1","RefSeq","NP_001334243.1","29706582","In inhibitory transmission onto hippocampal CA1 pyramidal cells, deletion of all beta subunits 1, 2, and 3 completely eliminated inhibitory responses. In addition, only knockout of beta3, alone or in combination with another beta subunit, impaired inhibitory synaptic transmission. expression of beta3 alone on the background of the beta1-3 subunit knockout was sufficient to restore synaptic and extrasynaptic inhibitory ..."
15020a20169,20172
> "Q9JLB0-1","RefSeq","NP_064323.2","30357511","The results indicate that the MPP6-Lin7 complex regulates myelin formation."
> "Q9JLB0-1","RefSeq","NP_064323.2","26496923","This paper herein showed the immunolocalization and interaction proteins of MPP6 in the mouse small intestine, and also that 4.1B in epithelial cells was not essential for the sorting of MPP6."
> "Q9JLB0-1","RefSeq","NP_064323.2","23306908","The findings indicate that the Src-MPP6-4.1G protein complex in Schmidt-Lanterman incisures(SLIs) has a role in signal transduction in the peripheral nervous system(PNS)."
> "Q9JLB0-1","RefSeq","NP_064323.2","22025680","In the mouse sciatic nerve, protein 4.1G colocalized at Schmidt-Lanterman incisures (SLI) and the paranodes with a member of the membrane-associated guanylate kinase (MAGUK) family, membrane protein palmitoylated 6."
15022c20174,20176
< "Q8BZQ2-1","RefSeq","NP_001297564.1","17616516","CRISPLD2 is expressed in the mandible, palate and nasopharynx regions during craniofacial development at E13.5-E17.5, respectively. Altogether, these data suggest that genetic variation in CRISPLD2 has a role in the etiology of NSCLP. Erratum:[Hum Mol Genet. 2008 Apr 1;17(7):1061. Arco-Burgos, Mauricio [corrected to Arcos-Burgos, Mauricio]]"
---
> "P62340-1","RefSeq","NP_035733.1","27680312","Overexpression and knockdown of TLP revealed that the levels of muscle-specific myosin heavy chain and the myogenic transcription factor myogenin are downregulated by TLP. The proximal AT-rich sequence of the myogenin promoter is responsible for TLP-mediated transcriptional repression."
> "P62340-1","RefSeq","NP_035733.1","27576952","Trf2 forms a stable complex with TFIIA or the testis expressed paralogue ALF chaperoned in the cytoplasm by heat shock proteins. It is recruited to active haploid cell promoters together with Tbp, Taf7l and RNA polymerase II. A set of genes activated in haploid spermatids during the first wave of spermatogenesis is down-regulated by Trf2 inactivation. Publication Status: Online-Only"
> "P62340-1","RefSeq","NP_035733.1","11352070","Role of TRF2 mRNA in male germ cells: In transgenic animals deficient in TRF2, spermatid development fails during early spermiogenesis with increased apoptosis and failure to develop testicular spermatozoa. Infertility phenotype in homozygote males."
15034a20189
> "Q8JZN3-1","RefSeq","NP_666075.1","23339194","Data indicate that rectifying potassium channel Kir2.4 interacts with G-protein subunit Galphao."
15036a20192,20195
> "Q9DAN6-1","RefSeq","NP_083073.1","29437694","Our findings indicate that GTSF1 is a crucial factor for the slicing of target RNAs by PIWI-piRNAs and thus affects secondary piRNA biogenesis in prospermatogonia."
> "Q9DAN6-1","RefSeq","NP_083073.1","19735653","Results indicate that Gtsf1/Cue110 is required for spermatogenesis and involved in retrotransposon suppression in male germ cells."
> "Q9DAN6-1","RefSeq","NP_083073.1","18706558","Expression pattern of Gtsf1 and its high conservation suggests that it may play an important role in germ cell development."
> "Q9DAN6-1","RefSeq","NP_083073.1","17919994","The Cue110 gene is expressed predominantly in male germ cells at stages from the pachytene spermatocytes to round spermatids"
15052,15053c20211,20213
< "Q61907-1","RefSeq","NP_001276941.1","28291718","Results show that hepatic PEMT protein levels and activity are post-translationally repressed in homocystinuria and correlates with decreased phosphatidylcholine."
< "Q61907-1","RefSeq","NP_001276941.1","28159867","Fenofibrate partially reversed hepatic steatosis and fibrosis in Pemt(-/-) mice when treatment was initiated after nonalcoholic fatty liver disease (NAFLD) had already been established. Increasing hepatic fatty acid oxidation can compensate for the lower VLDL-triacylglycerol secretion rate and prevent/reverse fatty liver disease in mice lacking PEMT."
---
> "O88513-1","RefSeq","NP_065592.1","29952003","Geminin acts as a tumor suppressor by safeguarding genome stability, whereas its overexpression is associated with genomic instability and enhanced tumorigenicity."
> "O88513-1","RefSeq","NP_065592.1","28690291","Geminin plays important roles in pre-meiotic DNA replication and subsequent spermatogenesis."
> "O88513-1","RefSeq","NP_065592.1","12192004","Role in inhibiting Cdt1-MCM6 interactions as well as a novel intrinsic Cdt1 DNA binding activity"
15056,15058d20215
< "Q80U63-1","RefSeq","NP_001272849.1","30136162","That Nuclear receptor subfamily 4 group A member 1 modulated Mfn2 expression via the MAPK-ERK-CREB signaling pathway"
< "Q80U63-1","RefSeq","NP_001272849.1","30017354","These results suggest that, as a potential key component of a novel and heretofore unrecognized mechanism of cytoplasmic protein transport, Mfn2 may play a general role in preserving neuromuscular synapses and serve as a common therapeutic target for skeletal muscle atrophy."
< "Q80U63-1","RefSeq","NP_001272849.1","15297672","Results suggest that the heptad repeat region (HR2) of mfn1 functions as a mitochondrial tether before fusion"
15065a20223,20224
> "P51855-1","RefSeq","NP_032206.1","20413906","The cause of cellular ATP depletion in nephrotic cystinosis may be the futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase"
> "P51855-1","RefSeq","NP_032206.1","20128681","Hypoxia decreased 2 key enzyme activities that regulate GSH synthesis, glutamate cysteine ligase (GCL) (E.C. 6.3.2.2) and glutathione synthase (GS) (E.C. 6.3.2.3)"
15074a20234
> "Q8BWW4-1","RefSeq","NP_001271452.1","26644407","Mouse LARP4 is regulated by TNF-alpha in a TTP-dependent manner. Publication Status: Online-Only"
15081,15082d20240
< "Q80W68-1","RefSeq","NP_001164456.1","29717104","KIRREL was overexpressed in gastric cancer. Publication Status: Online-Only"
< "Q80W68-1","RefSeq","NP_001164456.1","12538735","Analysis of five promoter-reporter gene constructs showed that regulatory elements driving expression encoded by exon 1A in kidney and brain are localized in region between -4 kb and 2.1 kb."
15092a20251,20252
> "Q99LJ7-1","RefSeq","NP_598844.3","25762510","Findings suggest that RC/BTB2 is a necessary component of the process of formation of primary cilia in somatic cells, perhaps through the transportation of cargos from Golgi bodies to centrosomes for cilia assembling."
> "Q99LJ7-1","RefSeq","NP_598844.3","22768142","The expression and localization of mouse RC/BTB2 in the testis and male germ cells, was characterized."
15093a20254,20257
> "Q08460-1","RefSeq","NP_034740.2","31194991","Tthe blockage of Cav1.2 increased the TC while reduced the iCa(2+) signal. Similar results were observed after the blockage of TRPs or BKCa. Therefore, caffeine promoted Ca(2+)-influx via TRPs and Cav1.2, and hyperpolarization through the activation of BKCa, inducing negative feedback of TC."
> "Q08460-1","RefSeq","NP_034740.2","30257105","Membrane potential-dependent regulation of L-type Ca(2+) channels appears to be important for histamine-, U46619-, and carbachol-induced phasic contractions in airway smooth muscle. Contractions can be abolished by BKCa channel openers, suggesting that these channels are potential targets for treating some causes of airway obstruction."
> "Q08460-1","RefSeq","NP_034740.2","30207167","Caveolae provide a key microdomain in renal collecting duct cells for coupling of TRPV4 with SK3, IK1, and BK that directly contributes to TRPV4-mediated Ca(2+) signaling in these domains."
> "Q08460-1","RefSeq","NP_034740.2","30354206","Caveolae play a critical role in protein targeting and preserving the close structural relationship between CaV3.2 and RyR needed to drive BKCa-mediated feedback control in resistance arteries."
15099a20264,20269
> "Q8C0X8-1","RefSeq","NP_941057.1","15289607","First described as a mouse-specific duplication of the MARK kinase family, and named MarkmE1"
> "Q8BZ98-1","RefSeq","NP_766234.1","28395327","In the mature epididymis, predominantly localized in principal cells of the distal segments"
> "Q8BZ98-1","RefSeq","NP_766234.1","27251629","The data of this study demonstrated that dynamin 3 is required for the formation, functional maturation, and subsequent survival of the calyx of Held."
> "Q8BZ98-1","RefSeq","NP_766234.1","24963135","In the developing neurons, there is a dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis. Publication Status: Online-Only"
> "Q8BZ98-1","RefSeq","NP_766234.1","24273169","Data indicate that coxsackievirus and adenovirus receptor (CAR) internalization was lipid microdomain-, actin-, and dynamin-dependent, and subsequently followed by CAR degradation in lysosomes."
> "Q8BZ98-1","RefSeq","NP_766234.1","19007685","Dynamin 3 participates in the growth and development of megakaryocytes."
15135a20306,20307
> "A2A8R0-1","RefSeq","NP_001334092.1","25170969","This study describes the expression of two SARA isoforms, SARA1 and SARA2, in mice and reports the generation and characterization of SARA mutant mice with FYVE domain deletion. The loss of SARA promoted skin tumor formation and malignant progression. Publication Status: Online-Only"
> "A2A8R0-1","RefSeq","NP_001334092.1","19257813","Osteoblast targeted expression of a mutant endofin protein lacking the pp1c binding activity results in sustained signaling of the BMP type I receptor, which increases bone formation and skeletal angiogenesis."
15137d20308
< "Q9JMB1-1","RefSeq","NP_035713.1","12748127","Deletion of either the C-terminal or N-terminal regions of the Theg protein did not affect spermatogenesis or fertility in the mouse."
15143a20315
> "E9Q355-1","RefSeq","NP_001158130.1","19516020","CATSPERG is predicted to be a single transmembrane-spanning protein with a large extracellular domain and a short intracellular tail."
15145a20318,20320
> "Q61220-1","RefSeq","NP_001276582.1","26586761","These findings identify NELL2 as an axon guidance cue and establish Robo3 as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion, inhibits Slit repulsion, and facilitates Netrin attraction to achieve a common guidance purpose."
> "Q61220-1","RefSeq","NP_001276582.1","15988128","NELL2 plays an important role in hippocampus-dependent spatial learning and that emotional learning does not depend critically on NELL2."
> "Q61220-1","RefSeq","NP_001276582.1","15094495","NELL2 plays an important role as a novel suppressor in long-term potentiation in vivo in the mouse dentate gyrus"
15146a20322,20342
> "Q9CZP5-1","RefSeq","NP_080060.1","27997587","COX7A2L/SCAFI and Pre-Complex III Modify Respiratory Chain Supercomplex Formation in Different Mouse Strains with a Bcs1l Mutation. Publication Status: Online-Only"
> "Q9CZP5-1","RefSeq","NP_080060.1","22829922","Metabolite profiles reveal energy failure and impaired beta-oxidation in liver of mice with complex III deficiency due to a BCS1L mutation."
> "Q9CZP5-1","RefSeq","NP_080060.1","21274865","The GRACILE mutation introduced into Bcs1l causes postnatal complex III deficiency and is a viable mouse model for mitochondrial hepatopathy."
> "Q9CZP5-1","RefSeq","NP_080060.1","17049929","The predominant expression of BCS1L in the floor plate of the neural tube region, together with its presence in peripheral ganglia from E13 onwards, indicates a role for BCS1L in the development of neural structures."
> "Q9CZP5-1","RefSeq","NP_080060.1","8599931","Studies in the yeast BCS1 ortholog indicate that the Bcs1 protein is anchored in the mitochondrial inner membrane, despite the absence of an N-terminal targeting sequence. Targeting occurs via charged amino acids near the transmembrane domain that act as an internal targeting signal."
> "Q6NXL6-1","RefSeq","NP_796077.2","29277914","In the present study demonstrate for the first time that SENP5 are ubiquitously distributed in the adult murine brain."
> "Q60960-1","RefSeq","NP_032491.2","29304174","Importin alpha1 is specifically required for the nuclear localization of several important HSV1 proteins, capsid assembly, and capsid egress into the cytoplasm, and may become rate limiting in situ upon infection at low multiplicity or in terminally differentiated cells such as neurons. Publication Status: Online-Only"
> "Q60960-1","RefSeq","NP_032491.2","28490747","HIV-1 Tat:nuclear localisation signal/cell penetrating peptide is able to form a stable and direct interaction with the classical nuclear import receptor importin-alpha. Publication Status: Online-Only"
> "Q60960-1","RefSeq","NP_032491.2","27434733","KPNA1 regulates satellite cell proliferation and survival by modulating nuclear import."
> "Q8BZP8-1","RefSeq","NP_783609.1","26323488","Findings demonstrate that neuropeptide S, via selective activation of the neurons bearing neuropeptide S receptor in the subiculum complex, ameliorates olfactory spatial memory impairment induced by scopolamine and MK801 in mice."
> "Q8BZP8-1","RefSeq","NP_783609.1","25979487","Study demonstrated that NPS produces anti-aggressive effects in mice through the selective activation of NPSR and that the endogenous NPS/NPSR system can exert a role in the control of aggressiveness levels under the present experimental conditions"
> "Q8BZP8-1","RefSeq","NP_783609.1","25788677","A single nucleotide polymorphism in Npsr1 that increases its activity is linked to higher anxiety."
> "Q8BZP8-1","RefSeq","NP_783609.1","25240770","The deletion of NPSR did not lead to compensatory changes in the vigilance-promoting effects of the CRF and Hcrt-1/Ox-A systems."
> "Q8BZP8-1","RefSeq","NP_783609.1","20171785","NPSR1 is essential in mediating NPS effects on behavior."
> "Q8BZP8-1","RefSeq","NP_783609.1","16829631","GPRA may contribute to the asthmatic phenotype by altering the activity of other pathways, such as neurally mediated mechanisms, that contribute to disease"
> "Q8BZP8-1","RefSeq","NP_783609.1","16891776","The isolation and characterization of an arginine vasotocin receptor in mice is reported."
> "Q9DCS1-1","RefSeq","NP_079602.4","27009467","Study characterized Tmem176a and b expression in RORgamma t+ lymphocytes at transcriptional and protein levels and present evidence that both genes exert a redundant ion channel function related to a colocalisation in close proximity to the Golgi apparatus. Publication Status: Online-Only"
> "Q9DCS1-1","RefSeq","NP_079602.4","20501748","These data suggest that Tmem176B and Tmem176A associate to form multimers and restrain dendritic cell maturation."
> "Q52KR2-1","RefSeq","NP_001297627.1","26651291","Lrig2 has a role in negative regulation of ectodomain shedding of axon guidance receptors by ADAM17 protease"
> "Q52KR2-1","RefSeq","NP_001297627.1","24023893","Phenotype of Lrig2E12-/- mice showed that Lrig2 was a promoter of PDGFB-induced glioma Publication Status: Online-Only"
> "Q52KR2-1","RefSeq","NP_001297627.1","24086156","At later stages, Lrig1 expression is sustained in non-sensory tissues, whereas Lrig2 levels are enhanced in neurons and sensory epithelia"
15149a20346,20349
> "Q8BU85-1","RefSeq","NP_796066.1","26649646","Results provide insight into the role of MsrB3 in hearing function and bring us one step closer to hearing restoration as a fundamental therapy"
> "Q8BU85-1","RefSeq","NP_796066.1","24583268","MsrB3 deficiency activates the cell cycle inhibitors p21 and p27."
> "Q8BU85-1","RefSeq","NP_796066.1","24191262","Data suggest that MsrB3 plays an essential role in maintaining the integrity of hair cells, possibly explaining the pathogenesis of DFNB74 deafness in humans caused by MSRB3 deficiency."
> "Q8BU85-1","RefSeq","NP_796066.1","15249228","Data suggest that, in mice, MsrB3 is largely or exclusively an endoplasmic reticulum-resident protein, and that the reduction of methionine-R-sulfoxides in different cellular compartments is provided by individual MsrB isozymes. [MsrB3]"
15151a20352,20354
> "P49446-1","RefSeq","NP_035342.3","25381250","GRB2 physically links cyt-PTPe with Src and enables cyt-PTPe to activate Src downstream of activated integrins in osteoclast-like cells."
> "P49446-1","RefSeq","NP_035342.3","24694598","PTPs alpha and epsilon play distinct roles in osteoclasts."
> "P49446-1","RefSeq","NP_035342.3","22722941","Multifaceted modulation of K+ channels by protein-tyrosine phosphatase epsilon tunes neuronal excitability."
15165a20369,20370
> "O35450-1","RefSeq","NP_063926.1","25767277","FKBPL is an important regulator of developmental and pathological angiogenesis."
> "O35450-1","RefSeq","NP_063926.1","15664193","Results demonstrate the importance of posttranslational stabilization of p21 protein by WISp39 in regulating cellular p21 activity."
15173d20377
< "Q3UHJ0-1","RefSeq","NP_001035195.1","29774516","Periodic variation in AAK1 expression is closely correlated to the decline in cognition in mouse model of Alzheimer's disease."
15187a20392,20395
> "Q9EPK8-1","RefSeq","NP_071300.2","30413814","Studied role of transient receptor potential cation channel subfamily V member 4 (Trpv4) in wound healing of sensory denervation corneal epithelium injury model."
> "Q9EPK8-1","RefSeq","NP_071300.2","30367945","Data suggest that transient receptor potential vanilloid type 4 channels are not involved in astrocyte volume regulation in situ; however, they play a protective role during the ischemia-induced brain edema formation."
> "Q9EPK8-1","RefSeq","NP_071300.2","30365528","Expression of TRPV4 and VNUT in normal human gastrointestinal cell derived cell lines Publication Status: Online-Only"
> "Q9EPK8-1","RefSeq","NP_071300.2","11827975","Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives."
15190a20399,20402
> "Q03146-1","RefSeq","NP_766550.1","29930002","DDR1 promotes RUNX2 activity and atherosclerotic vascular calcification in diabetes mellitus via phosphoinositide 3-kinase/Akt signaling."
> "Q03146-1","RefSeq","NP_766550.1","29298894","Data (including data from studies using knockout mice) suggest that Ddr1 plays role in promoting mammary tumor growth; tumor-extrinsic Ddr1 appears to be required for promotion of mammary tumors by interleukin-6."
> "Q03146-1","RefSeq","NP_766550.1","29483153","The data suggest that the absence of DDR1 provides a growth and adhesion advantage that favors the expansion of basal cells, potentiates fibrosis, and enhances necrosis/hypoxia and basal differentiation of transformed cells to increase their aggression and metastatic potential."
> "Q03146-1","RefSeq","NP_766550.1","27915093","DDR1 kinase activity is required for regulating collagen IV synthesis."
15193a20406,20409
> "Q9JIF9-1","RefSeq","NP_001028793.1","19878039","Myotilin does not have a significant influence on muscle mass, muscle fiber size, or regulation of muscle contraction. Alternatively, compensatory over-expressions of other elements may compensate for the lack of myotilin."
> "Q9JIF9-1","RefSeq","NP_001028793.1","18335471","In single-transgenic mutant mice, double-transgenic mice overexpressing myotilin showed more severe muscle degeneration, enhanced myofibrillar aggregation, and earlier onset of aggregation."
> "Q9JIF9-1","RefSeq","NP_001028793.1","17074808","Either myotilin does not participate in muscle development and basal function maintenance or other proteins serve as structural and functional compensatory molecules when myotilin is absent"
> "Q9JIF9-1","RefSeq","NP_001028793.1","15752755","Features suggest an important role for myotilin in sarcomere organization."
15194a20411
> "Q5XF90-1","RefSeq","NP_001158085.1","19731010","Data suggest that ATP13A4 may play a vital role in the developing nervous system and its impairment can contribute to the symptoms seen in autism spectrum disorder."
15196a20414
> "Q9EQW8-1","RefSeq","NP_072087.2","27793051","This study revealed the involvement of Ndst4 in the development and homeostasis of colonic epithelium"
15206a20425,20427
> "Q80TS3-1","RefSeq","NP_941991.1","27091502","Data show that Unc5 cell guidance receptor Unc5D controls Latrophilin3 (LPHN3)-FLRT protein FLRT2-mediated cell adhesion. Publication Status: Online-Only"
> "Q80TS3-1","RefSeq","NP_941991.1","26235031","The crystal structure of the OLF/FLRT3 complex shows that LPHN3-OLF in the closed state binds with high affinity to the concave face of FLRT3-LRR with a combination of hydrophobic and charged residues."
> "Q80TS3-1","RefSeq","NP_941991.1","22575564","Null mutant Lphn3 mice had a hyperactive phenotype in the open field test, independent of sex, and were more sensitive to locomotor stimulation."
15216d20436
< "Q3TTY0-1","RefSeq","NP_001074876.1","23943622","Sperm surface phospholipase B is activated in response to sterol removal"
15226a20447,20449
> "O35618-1","RefSeq","NP_032601.2","30012555","Selective dysregulation of Mdm2 and Mdm4 alternative splicing underlies p53 anti-repression and motor neuron death in a mouse model of spinal muscular atrophy."
> "O35618-1","RefSeq","NP_032601.2","24013503","Identify Mdm4 as one of these key mRNAs that senses the defects in the spliceosomal machinery and transduces the signal to activate the p53 response"
> "Q5SDA5-1","RefSeq","NP_001007577.1","17255100","Guanylate cyclase 1 and guanylate cyclase 2 have roles in function of rod and cone photoreceptors"
15228a20452
> "Q99LS1-1","RefSeq","NP_598600.1","21536470","During organogenesis Mmachc and Mmadhc may interact in only a subset of cells."
15232a20457
> "E9QA62-1","RefSeq","NP_001074626.1","25774500","LMOD3 deficiency in mice causes nemaline myopathy. In skeletal muscle, Lmod3 transcription was controlled by SRF and MEF2. LMOD3 and KLHL40 enhanced MRTF-SRF activity."
15238a20464,20471
> "P51125-1","RefSeq","NP_001288110.1","30190286","These results suggest that CAST and ELKS work in concert to promote retinal synapse formation, transmission, and maintenance."
> "P51125-1","RefSeq","NP_001288110.1","29355642","The knockdown of CAST in mutant huntingtin-expressing cells and the knockout of the Cast gene in a knock-in mouse model of HD resulted in a worsening of the molecular HD-related hallmarks including elevated formation of huntingtin fragments and increased amount of respective aggregates"
> "P51125-1","RefSeq","NP_001288110.1","29089532","Mice that were either wild type (WT) or overexpressing calpastatin (CAST Tg), the endogenous inhibitor of calpains were fed with high (60% kcal) fat diet for 16 weeks. CAST overexpression significantly reduced adipocyte apoptosis, adipose tissue collagen and macrophage accumulation; and significantly attenuated obesity-induced inflammatory responses in adipose tissue. Publication Status: Online-Only"
> "P24604-1","RefSeq","NP_001106935.1","29129599","Inhibition of ITK and RLK attenuated psoriasis-associated signaling pathways, indicating that PRN694 is an effective psoriasis therapeutic."
> "P24604-1","RefSeq","NP_001106935.1","28415764","Results suggest that Tec kinase involves in acute inflammation process in LPS-stimulated RAW264.7 macrophages cells via NF-kappaB pathway."
> "P24604-1","RefSeq","NP_001106935.1","28275136","These data indicate that in mature B cells, Tec and Btk may compete for activation of the Akt signaling pathway, whereby the activating capacity of Btk is limited by the presence of Tec kinase."
> "P24604-1","RefSeq","NP_001106935.1","26026062","Btk, Tec, Bmx are required for TLR-dependent signaling in many types of myeloid cells while being tissue-specific."
> "P24604-1","RefSeq","NP_001106935.1","25993510","Tec enhances c-Maf-dependent IL-4 promoter activity. This effect of Tec is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf thereby attenuating its transcriptional activity. Publication Status: Online-Only"
15245a20479,20480
> "O35308-1","RefSeq","NP_065262.1","18524945","Disruption of Mct3 leads to a potentially reversible decrease in subretinal space pH, thereby reducing the magnitude of the light suppressible photoreceptor current."
> "O35308-1","RefSeq","NP_065262.1","17318265","MCT8-null mice developed without overt deficits but also exhibited distorted 3,5,3'-triiodothyronine (T3) and thyroxine (T4) serum levels, resulting in increased hepatic activity of type 1 deiodinase (D1)."
15246a20482,20483
> "Q3UFJ6-1","RefSeq","NP_659163.3","19097053","These data suggest that Sdmg1 is a component of regulated secretory granules in exocrine secretory cells and that the developmental regulation of Sdmg1 expression is related to a role for Sdmg1 in post-Golgi membrane trafficking."
> "Q3UFJ6-1","RefSeq","NP_659163.3","18321981","Identified a conserved transmembrane protein, Sdmg1, owing to its male-specific expression in embryonic gonads"
15251a20489,20493
> "Q9CPU9-1","RefSeq","NP_079562.1","28507097","Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2"
> "Q9CPU9-1","RefSeq","NP_079562.1","26342034","The increase in granular staining and heparin content is compatible with an impact of Ctr2 on mast cell maturation and, in support of this, the absence of Ctr2 resulted in markedly increased mRNA expression, storage, and enzymatic activity of tryptase."
> "Q9CPU9-1","RefSeq","NP_079562.1","24522273","In mouse embryo fibroblasts, reduction of CTR1 expression renders cells resistant to cisplatin whereas reduction of CTR2 makes them hypersensitive both in vitro and in vivo."
> "Q9CPU9-1","RefSeq","NP_079562.1","24167251","Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain."
> "Q9CPU9-1","RefSeq","NP_079562.1","20930109","Copper transporter 2 regulates the transport of cisplatin through control of the rate of macropinocytosis. Erratum:[Mol Pharmacol. 2011 May;79(5):894-8]"
15256a20499,20502
> "Q91W90-1","RefSeq","NP_663342.3","29535165","TXNDC5 mRNA and protein were highly upregulated in hypertrophied/failing mouse left ventricle. Targeted disruption of Txndc5 in mice revealed protective effects against isoproterenol-induced cardiac hypertrophy, reduced fibrosis by approximately 70%, and markedly improved left ventricle function."
> "Q91W90-1","RefSeq","NP_663342.3","23326410","Hypoxia induced TXCNDC5 expression, which contributed to adiponectin expression, cytokine production and the cellular proliferation and migration of fibroblasts in rheumatoid arthritis."
> "Q91W90-1","RefSeq","NP_663342.3","14971039","PC-TRP was expressed at high levels in all plasma cells isolated from bone marrow or lamina propria."
> "Q91W90-1","RefSeq","NP_663342.3","12930873","Both ERp19 and ERp46 and their respective mRNAs are highly expressed in the liver as compared with other tissues"
15257a20504,20508
> "Q9EPK2-1","RefSeq","NP_598430.1","26936825","This study identifies ARL3 as a key player in prenylated protein trafficking in rod photoreceptor cells and establishes the potential role for ARL3 dysregulation in the pathogenesis of RP2-related forms of X-linked retinitis pigmentosa"
> "Q9EPK2-1","RefSeq","NP_598430.1","26358772","We first performed detailed characterization of the Rp2-knockout (Rp2-KO) mice and observed early-onset cone dysfunction"
> "Q9EPK2-1","RefSeq","NP_598430.1","26383048","RP2 has a role in cone photoreceptor sensory cilium elongation in mice"
> "Q9EPK2-1","RefSeq","NP_598430.1","23745007","Our studies suggest that RP2 contributes to the maintenance of photoreceptor function and that cone opsin mislocalization represents an early step in XLRP caused by RP2 mutations. Publication Status: Online-Only"
> "Q9EPK2-1","RefSeq","NP_598430.1","20106869","We propose that RP2 regulation of Arl3 is important for maintaining Golgi cohesion, facilitating the transport and docking of vesicles and thereby carrying proteins to the base of the photoreceptor connecting cilium for transport to the outer segment."
15262a20514,20519
> "Q9JLY0-1","RefSeq","NP_061291.2","26503265","Results suggest: 1) SOCS6 and SOCS7 bind tyrosine-phosphorylated DAB1 and commit it to ubiquitination and proteasomal degradation. 2) Removal of phosphorylated DAB1 by SOCS6 and SOCS7 terminates reelin signaling and allows a new cycle of reelin signaling to commence. 3) Repeated cycles of reelin signaling 'ON' and 'OFF' drive the fundamentally cyclic process of cell migration in the cortex."
> "Q9JLY0-1","RefSeq","NP_061291.2","24284072","Our results show that endogenous Cul5 suppresses epithelial cell transformation by several pathways, including inhibition of Src-Cas-induced ruffling through SOCS6"
> "Q9JLY0-1","RefSeq","NP_061291.2","15123678","SOCS-6 expression is induced by insulin, which regulates its binding to the p85 monomer of phosphoinositide 3-kinase"
> "Q9JLY0-1","RefSeq","NP_061291.2","14707129","SOCS6 has a role as a negative regulator of receptor tyrosine kinases"
> "Q9JLY0-1","RefSeq","NP_061291.2","12396724","SOCS4 expression, in contrast, does not appear to be EPO inducible.SOCS4 is ineffective at counteracting EPO-mediated events."
> "Q9JLY0-1","RefSeq","NP_061291.2","12052866","SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation(SOCS-6)"
15275,15277c20532,20540
< "P58771-1","RefSeq","NP_001157720.1","30567734","Tropomyosin pseudo-phosphorylation results in dilated cardiomyopathy."
< "P39054-1","RefSeq","NP_001240822.1","30291191","DNM2 knockdown via two different strategies can efficiently correct the myopathy due to DNM2 mutations."
< "Q6PDG5-1","RefSeq","NP_001107569.1","27392482","These findings demonstrate involvement of BAF170-dependent chromatin remodeling in hippocampal neurogenesis."
---
> "Q8BJX2-1","RefSeq","NP_808324.1","17971504","6820408C15Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
> "Q80XG9-1","RefSeq","NP_848846.3","23911104","This study demonistrated that LRRTM4-HSPG complex mediates excitatory synapse development on dentate gyrus granule cells."
> "P98083-1","RefSeq","NP_035498.2","30207172","Document a genetic link between the p66ShcA locus and accelerated aging phenotype(s) in kidneys of diabetic mice."
> "P98083-1","RefSeq","NP_035498.2","30091687","These results suggest that p66Shc may regulate the relative abundance and timing of lineage-associated transcription factor expression in the blastocyst inner cell mass ."
> "P98083-1","RefSeq","NP_035498.2","30047409","A complex epigenetic mechanism linking miRNAs and chromatin modifying enzymes drive persistent p66 Shc transcription and reactive oxygen species generation."
> "P98083-1","RefSeq","NP_035498.2","29930100","Genetic inhibition of ShcA signaling in the Polyoma virus middle T (MT) breast cancer mouse model sensitized mammary tumors to biguanides during the earliest stages of breast cancer progression."
> "Q9D6J1-1","RefSeq","NP_080334.3","26887952","These results suggest that the phosphorylation of ceramide synthases may be a key regulatory point in the control of the distribution and levels of sphingolipids of various acyl-chain lengths."
> "Q9D6J1-1","RefSeq","NP_080334.3","25705848","CerS4-directed epidermal ceramide composition is essential to control hair follicle stem and progenitor cell behavior potentially through its regulation of BMP and Wnt signaling"
> "Q9D6J1-1","RefSeq","NP_080334.3","12912983","Lag1p family members trh1 and trh4 regulate (dihydro)ceramide synthases responsible for production of sphingolipids containing different fatty acids"
15282a20546,20550
> "P84078-1","RefSeq","NP_031502.1","30472514","Results suggest that the peptide derived from ARF1 could be developed into a novel anti-allergic agent for therapeutic intervention in allergy and mast cell-related pathologies."
> "P84078-1","RefSeq","NP_031502.1","30102570","Findings define a novel role of SHP2 in stabilizing junctional VE-cadherin in the resting endothelial barrier through suppressing MET and ARF1 activation"
> "P84078-1","RefSeq","NP_031502.1","28621666","The authors found that Arf1 occupies contrasting molecular environments within the Coat Protein Complex I, leading them to hypothesize that some Arf1 molecules may regulate vesicle assembly while others regulate coat disassembly. Publication Status: Online-Only"
> "P84078-1","RefSeq","NP_031502.1","12376537","Termination of Arf1 signals mediated through GGA require that Arf1.GTP dissociates from GGA prior to interaction with GAP and consequent hydrolysis of GTP"
> "P84078-1","RefSeq","NP_031502.1","11914273","A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling"
15290a20559,20565
> "Q61735-1","RefSeq","NP_034711.1","30929259","This study shows that miR-378a modulates macrophage phagocytosis and differentiation through targeting CD47-SIRPalpha axis in atherosclerosis"
> "O09044-1","RefSeq","NP_033248.1","30811271","Findings suggest that stx11 regulates the stimulus-dependent transport of TLR4 to the plasma membrane by cooperating with SNAP-23 in macrophages. Our results clarify the regulatory mechanisms underlying intracellular transport of TLR4 and have implications for microbial pathogenesis and immune responses."
> "O09044-1","RefSeq","NP_033248.1","29762713","The Kif5-SNAP23 complex interacts with mGlu1a receptor."
> "O09044-1","RefSeq","NP_033248.1","30102258","Data demonstrate a role for SNAP23 in the control of adipocytemacroautophagy and programmed cell death through an ATG9-dependent, but ATG7-independent, pathway regulating BAX protein levels and BAX activation."
> "O09044-1","RefSeq","NP_033248.1","29771640","SNAP-23 phosphorylation at Ser95 played an important role in the regulation of SNARE-dependent membrane fusion during FcR-mediated phagocytosis."
> "P70460-1","RefSeq","NP_033525.2","29507126","VASP is a major regulator of leukocyte recruitment and polarization in postischemic revascularization and data support a novel role of VASP in chemokine receptor trafficking."
> "P70460-1","RefSeq","NP_033525.2","29344719","Myocardial ischemic preconditioning-induced VASP phosphorylation in platelets is a protective mechanism against the deleterious effects of ischemia. Publication Status: Online-Only"
15303a20579,20580
> "Q3TWL2-1","RefSeq","NP_001297436.1","31329883","The TMEM55B has been implicated in starvation induced lysosomal translocation. Amino acid starvation induces perinuclear lamp1 clustering in RAW264.7 macrophages, which was attenuated by shRNA-mediated knock-down or CRISPR/Cas9-mediated knock-out of TMEM55B."
> "P00015-1","RefSeq","NP_034119.1","16757556","T-Cc can catalyze reduction of H(2)O(2) 3 times faster than somatic cell Cc(S-Cc); T-Cc heme has greater resistance to degradation by H(2)O(2); implies T-Cc can protect sperm from H(2)O(2)damage; T-Cc apoptotic activity is 3 to 5 times greater than S-Cc"
15314a20592,20595
> "Q9R1C8-1","RefSeq","NP_067333.1","29778944","Results suggest that degeneration of the nigrostriatal pathway causes the decreased dopamine levels in the limbic and limbic related brain regions and the enhanced sensitivity of the 5-HT6 receptor on the glutamate and GABA neurons in the basolateral amygdala, which appear to be an etiologic and pathophysiological factor for anxiety in Parkinson's disease."
> "Q9R1C8-1","RefSeq","NP_067333.1","29896304","Intracellular 5-hydroxytryptamine receptors (5-HT6R) signaling was found to be linked to RhoA GTPase activation and was involved in the maturation of osteoclasts. This signaling pathway also showed enhanced bone destruction after lipopolysaccharide (LPS) administration in mice. Publication Status: Online-Only"
> "Q9R1C8-1","RefSeq","NP_067333.1","28931427","This study suggested that 5-HT6 plays a critical role in Alzheimer's disease development through regulating the morphology and function of neuronal primary cilia, which is possibly related to the AIS and axon alterations in Alzheimer's disease development. Publication Status: Online-Only"
> "Q9R1C8-1","RefSeq","NP_067333.1","28087224","Results implicate a role of 5-HT6 receptor signaling in primary cilia morphology, suggest that 5-HT6 receptor research should consider relative levels of receptor expression when evaluating their impact on primary cilia function."
15318a20600,20604
> "P22437-1","RefSeq","NP_032995.1","30811756","Expression of COX-1 and production of thromboxane A2 in platelets of STZ-induced diabetic mice were elevated."
> "P22437-1","RefSeq","NP_032995.1","29676940","The highly expressed knockin COX-2 enzyme barely makes any PGs or thromboxane in neonatal P8 or adult mice, demonstrating that prostanoid biosynthesis requires native COX-1 and cannot be rescued by the knockin COX-2. In summary, the 2 COX isoforms can preferentially compensate for some renal functions, which appears to be independent of the PG-synthetic capacity."
> "P22437-1","RefSeq","NP_032995.1","8121489","Prostaglandin G/H synthase is a moonlighting protein that functions both as a peroxidase as well as a cyclooxygenase."
> "O54781-1","RefSeq","NP_033300.2","23197718","SRPK2 may contribute to the formation of hyperphosphorylated tau and the pathogenesis of Alzheimer disease."
> "O54781-1","RefSeq","NP_033300.2","19592491","Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons."
15319a20606
> "Q61214-1","RefSeq","NP_031916.1","30227164","Increased dosage of DYRK1A, a gene that lies within Hsa21, causes abnormalities in the proliferation and neuronal/astrocytic differentiation of neural progenitor cells in the Down Syndrome embryonic brain. Review article"
15332a20620,20623
> "Q8BHK6-1","RefSeq","NP_653122.2","28424516","Phagocytosis of haematopoietic tumour cells during SIRPalpha-CD47 blockade was strictly dependent on SLAM family receptors in vitro and in vivo; in both mouse and human cells, this function required a single SLAM family member, SLAMF7 (also known as CRACC, CS1, CD319), expressed on macrophages and tumour cell targets"
> "Q8BHK6-1","RefSeq","NP_653122.2","24098802","CRACC-CRACC interaction between Kupffer and NK cells contributes to poly I:C/D-GalN induced hepatitis. Publication Status: Online-Only"
> "Q8BHK6-1","RefSeq","NP_653122.2","19151721","CRACC was a critical positive regulator of NK cell function mediated by EAT-2."
> "Q8BHK6-1","RefSeq","NP_653122.2","17981603","2B4, NTB-A and CRACC have roles in the regulation of Natural Killer cell function [review] Review article Publication Status: Online-Only"
15344d20634
< "Q6PE87-1","RefSeq","NP_001333991.1","17971504","1700003M02Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons and testis, and is predicted to be important to cilia."
15345a20636,20641
> "Q9CR50-1","RefSeq","NP_080833.1","23449389","Findings indicate that PIRH2 has central roles in the ubiquitylation of Chk2 and its turnover and in the regulation of its function."
> "Q9CR50-1","RefSeq","NP_080833.1","21994467","This study provides evidence that the ubiquitination of p73 mediated by Pirh2 represents an important pathway for controlling the suppressive function of p73"
> "Q9CR50-1","RefSeq","NP_080833.1","22125490","These data reveal the in vivo roles of Pirh2 in the regulation of p53 and c-Myc stability and support its role as a tumor suppressor"
> "Q9CR50-1","RefSeq","NP_080833.1","15547185","These results are consistent with the hypothesis that increased Pirh2 expression affects lung tumorigenesis by reducing p53 activity."
> "Q9CR50-1","RefSeq","NP_080833.1","12654245","This protein is a p53-induced ubiquitin-protein ligase which promotes p53 degradation. GeneRIF: Pirh2 (Zfp363), a gene regulated by p53, encodes a RING-H2 domain-containing protein with intrinsic ubiquitin-protein ligase activity.  Pirh2 physically interacts with p53 and promotes ubiquitination and degradation of p53 independently of Mdm2."
> "Q9CR50-1","RefSeq","NP_080833.1","12200228","Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity [androgen-receptor N-terminal-interacting protein; mARNIP]"
15353,15354d20648
< "Q64332-1","RefSeq","NP_001104485.1","30858140","Synapsin II regulates synaptic transmission and neurite growth in cultured hippocampal neurons."
< "Q64332-1","RefSeq","NP_001104485.1","28922833","Results reveal a permissive contribution of Syn2 to the expression of normal socio-communicative behavior"
15357a20652,20654
> "Q9ESM3-1","RefSeq","NP_071314.1","30125937","Hapln4/Bral2 is a perineuronal nets component that selectively contributes to formation and transmission of Purkinje cells-deep cerebellar nuclei synapses in the cerebellum"
> "Q9ESM3-1","RefSeq","NP_071314.1","20181608","These findings provide an understanding of the mechanisms underlying the accumulation of cations due to diffusion barriers around the nodes during saltatory conduction, emphasizing the importance of the Bral1-based extramilieu for neuronal conductivity."
> "Q9ESM3-1","RefSeq","NP_071314.1","11817897","Colocalizing with the versican V2 isoform at the nodes of Ranvier in developing and adult mouse central nervous systems."
15371a20669,20678
> "P97450-1","RefSeq","NP_058035.1","22258022","Coupling factor 6 overexpression induced salt-sensitive hypertension, complicated by systolic cardiac dysfunction, but its onset was delayed in females. Estrogen has an important role in the regulation of coupling factor 6-mediated pathophysiology."
> "P97450-1","RefSeq","NP_058035.1","22306848","Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by downregulating Akt signaling, thereby cancelling its benefit for cardiac function in mice."
> "P97450-1","RefSeq","NP_058035.1","22038518","CF6 plays a crucial role in the development of insulin resistance and hypertension"
> "P97450-1","RefSeq","NP_058035.1","20811295","Coupling factor 6 induces the development of systolic dysfunction and upregulation of nicotinamide adenine dinucleotide phosphate oxidase in the heart under the high-salt diet"
> "P97450-1","RefSeq","NP_058035.1","16309857","Identification of functional elements in bi-directional promoter"
> "Q64332-1","RefSeq","NP_038709.1","30858140","Synapsin II regulates synaptic transmission and neurite growth in cultured hippocampal neurons."
> "Q64332-1","RefSeq","NP_038709.1","28922833","Results reveal a permissive contribution of Syn2 to the expression of normal socio-communicative behavior"
> "Q9R059-1","RefSeq","NP_034343.2","26499038","Four and a half LIM domain protein 3 could interact with MyoD, cyclic AMP-responsive elements and phosphorylated cAMP response element binding protein in vivo"
> "Q9R059-1","RefSeq","NP_034343.2","15117962","FHL2 and FHL3, respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells"
> "Q9R059-1","RefSeq","NP_034343.2","12704194","Actin was identified as a FHL3 binding partner; FHL3 is a significant regulator of actin cytoskeletal dynamics in skeletal myoblasts."
15372a20680,20681
> "P23591-1","RefSeq","NP_112478.1","20573072","Fucosylation-modified Notch receptor may represent a novel extrinsic regulator for hematopoietic stem cells (HSC) engraftment and HSC niche maintenance."
> "Q3USJ8-1","RefSeq","NP_950177.2","23437151","Our results suggest that FCHSD1 and FCHSD2 could modulate F-actin assembly or maintenance in hair cell stereocilia and cuticular plate."
15381,15383d20689
< "Q6RHR9-1","RefSeq","NP_001025021.1","27707879","The interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure"
< "Q6RHR9-1","RefSeq","NP_001025021.1","23523645","ARIP1 and ARIP2 are co-expressed in some nerve cells and their biological activities are distinct."
< "Q5DTW7-1","RefSeq","NP_001276590.1","29728365","We characterized two factors, MORC2A and RESF1, of which RESF1 is a novel molecule in retroelement silencing. Although both factors are recruited to repress provirus, their roles in repression are different. MORC2A appears to function dependent on repressive epigenetic modifications, while RESF1 regulates repressive epigenetic modifications associated with SETDB1"
15396a20703,20705
> "Q8BMJ8-1","RefSeq","NP_796056.2","29967281","SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression. Publication Status: Online-Only"
> "Q8BMJ8-1","RefSeq","NP_796056.2","15358670","Sp8 and Sp9, via Fgf8, are involved in mediating the actions of Fgf10 and Wnt/beta-catenin signaling during vertebrate limb outgrowth."
> "Q8BMJ8-1","RefSeq","NP_796056.2","14526104","Observations indicate that Sp8 functions downstream of Wnt3, Fgf10, and Bmpr1a in the signaling cascade that mediates apical ectodermal ridge formation"
15413,15414c20722,20723
< "Q71RI9-1","RefSeq","NP_001280489.1","20482848","KAT III inhibited by equimolar methionine and half-life is 3.9 minutes at 65 degree C. Publication Status: Online-Only"
< "Q71RI9-1","RefSeq","NP_001280489.1","19029248","The biochemical and structural properties of mouse KAT III (mKAT III) were determined. Erratum:[Mol Cell Biol. 2018 Apr 30;38(10 ):. PMID: 29712768]"
---
> "Q8R4G0-1","RefSeq","NP_597995.1","28074533","Decreased Ntng1 expression was initially observed in the nucleus accumbens of mice conditioned to cocaine."
> "Q8R4G0-1","RefSeq","NP_597995.1","11906208","Selectively expressed in distinct neuronal subsets that include populations in forebrain, midbrain, hindbrain, spinal cord, and spinal ganglia"
15423a20733,20743
> "Q6KAR6-1","RefSeq","NP_796307.2","15878854","The exocyst complex serves to selectively regulate the docking of insulin-containing vesicles at sites of release close to the plasma membrane"
> "Q8BKV0-1","RefSeq","NP_076178.1","25138526","These results demonstrate that Spock3 plays an important role in the formation or maintenance of major neuronal structures in the brain."
> "Q8BKV0-1","RefSeq","NP_076178.1","23418755","The expression of testican-3 in adult mice is restricted to the brain and located diffusely within the extracellular matrix."
> "Q61979-1","RefSeq","NP_851291.1","30279096","Nnat deletion was associated with postnatal growth restriction and adult obesity."
> "Q61979-1","RefSeq","NP_851291.1","23527188","Nnat expression in hypothalamus is regulated by short-term nutrient availability, but unaltered by diet-induced obesity or calorie restriction."
> "O70165-1","RefSeq","NP_032021.1","30818229","Lipopolysaccharide-induced inflammation can induce a significant ficolin response."
> "O70165-1","RefSeq","NP_032021.1","28844702","Ficolin-2 induces macrophage activation, promotes M1 polarization and facilitates proliferation and antigen-specific cytotoxicity of CD8(+) T cells. Ficolin-2 binds to Toll-like receptor 4 (TLR4) on macrophages and DCs and promotes their antigen-presenting abilities to CD8(+) T cells."
> "O70165-1","RefSeq","NP_032021.1","28380665","This study shows that FCN-A/2 exacerbated the inflammatory pathogenesis of inflammatory bowel disease by stimulating M1 polarization through the TLR4/MyD88/MAPK/NF-kappaB signalling pathway in macrophages"
> "O70165-1","RefSeq","NP_032021.1","27467404","This study demonstrates that ficolins are important in initial innate host defense against Aspergillus fumigatus infections in vivo"
> "O70165-1","RefSeq","NP_032021.1","16328467","Ficolin A protein (smapshowed a potent complement activating capacity.These results suggest that ficolin A and its variant function as recognition molecules of the lectin pathway."
> "O70165-1","RefSeq","NP_032021.1","15950722","The expression pattern of ficolin A expression was closely similar to that of mannose-binding lectin-associated serine proteases, suggesting that these molecules may function in coordination as components of the lectin complement pathway"
15441,15443d20760
< "Q00420-1","RefSeq","NP_001258397.1","25200183","SIRT7 stabilizes and activates the GABP alpha/GABPbeta complex via deacetylation of GABPbeta1."
< "Q00420-1","RefSeq","NP_001258397.1","22862946","The findings identify the tetramer-forming GABPbeta1 as specific HSC regulators and potential therapeutic targets in treating LSC-based hematological malignancy."
< "Q00420-1","RefSeq","NP_001258397.1","21944889","After antigenic stimulation CD4+/CD62Lhigh cells from Peyer's patches express a greater amount of transcripts of GA-binding protein beta subunit 1 than those from the spleen."
15457a20775,20777
> "P63239-1","RefSeq","NP_038656.1","29800682","Pancreatic cancer-derived exosomes (Exo-Mia) suppress the synthesis of GIP and GLP-1 from STC-1cells in vitro by down-regulating the PCSK1/3"
> "P63239-1","RefSeq","NP_038656.1","28476408","Study reveals a significant reduction of tachykinin and opioid neuropeptides level in proprotein convertase 1 and proprotein convertase 2 mutant mouse spinal cords."
> "P63239-1","RefSeq","NP_038656.1","29198128","Oxygen and glucose deprivation or middle cerebral artery occlusion stress caused substantial cell death in a dose-dependent manner. With the increasing OGD dose, proPC1 and PC1 proteins gradually increased. In vivo the proPC1 and PC1 expressions presented with a peak at 4-h and then decreased at 24-h reperfusion. The results suggest that the increasing PC1 expression promoted the transformation of proCgA into CgA or small"
15461a20782,20785
> "Q62440-1","RefSeq","NP_035729.3","30045946","These findings indicate that Tle corepressors are differentially partitioned to Runx and Tcf/Lef complexes to instruct CD8(+) lineage choice and cooperatively establish CD8(+) T cell identity, respectively."
> "Q62440-1","RefSeq","NP_035729.3","28744818","Demethylation of TLE1 promoter region activates the self-expression in diabetic mice intestinal epithelium cells (IECs). Subsequently, TLE1, through the transcriptional suppression on expression of Hes1, contributes to the aberrant differentiation of IECs in DM mice."
> "Q62440-1","RefSeq","NP_035729.3","26831087","Loss of Tle1 not only results in increased phosphorylation and activation of proinflammatory NF-kappaB but also results in decreased Hes1 (hairy and enhancer of split-1), a negative regulator of inflammation in macrophages"
> "Q62440-1","RefSeq","NP_035729.3","12359720","Grg1-S may operate in conjunction with beta-catenin and Tcf factors to regulate vertebrate gut epithelial cell differentiation"
15470,15472d20793
< "Q05BQ1-1","RefSeq","NP_001139272.1","24647940","These results provide genetic evidence for a specific role of IgSF9 in inhibitory synapse development/maintenance, presumably by its cell adhesion molecule-like activity."
< "Q05BQ1-1","RefSeq","NP_001139272.1","18268009","Dendrite arborization phenotype was caused by off-target effects and that Dasm-1 is dispensable for hippocampal dendrite arborization"
< "Q05BQ1-1","RefSeq","NP_001139272.1","15755926","Review. Dasm1, a protein likely to function as a neuronal cell-surface receptor, plays an important role in both shaping the dendritic tree and affecting the fraction of electrically active glutamatergic synapses. Review article Publication Status: Online-Only"
15474a20796,20799
> "Q80YV2-1","RefSeq","NP_766323.1","22955283","Data show that cell cycle-dependent phosphorylation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA)is mediated by extracellular signal-regulated kinase 2 (ERK2)."
> "Q80YV2-1","RefSeq","NP_766323.1","22696294","Results reveal a novel role for NIPA in meiosis."
> "Q80YV2-1","RefSeq","NP_766323.1","22205987","Phosphorylated NIPA is degraded in late mitosis in an APC/C(Cdh1)-dependent manner"
> "Q80YV2-1","RefSeq","NP_766323.1","12748172","NIPA has an antiapoptotic role in NPM-ALK-mediated signaling events"
15481c20806,20811
< "Q9D2P8-1","RefSeq","NP_001034454.1","26801084","MOBP synthesis is stimulated by Fyn activity."
---
> "Q61599-1","RefSeq","NP_031512.1","26469087","Ly-GDI is a critical regulator of inflammatory injury after deposition of IgG immune complexes and that it negatively regulates the lung NF-kappaB activity. Publication Status: Online-Only"
> "Q61599-1","RefSeq","NP_031512.1","25778399","These results indicate that RhoGDIbeta functions as a novel BMP4 signaling target that regulates adipogenesis and myogensis."
> "Q61599-1","RefSeq","NP_031512.1","22777355","Rictor regulates cell migration by suppressing RhoGDI2."
> "Q61599-1","RefSeq","NP_031512.1","21518140","Raptor siRNA suppressed the effects of GM3 on Ly-GDI expression and Akt phosphorylation at Thr(308) , suggesting GM3 signals to be transduced to mTOR-Raptor and Akt-Thr(308) , leading to Ly-GDI stimulation"
> "Q61599-1","RefSeq","NP_031512.1","17049467","Impaired interaction of RhoGDIbeta with Rac1 isoprenyl groups possibly makes RhoGDIbeta function as a positive regulator for Rac1 during metastasis."
> "Q61599-1","RefSeq","NP_031512.1","17142749","Rho GDIalpha and Rho GDIbeta play synergistic roles in lymphocyte migration and development by modulating activation cycle of the Rho proteins in a lymphoid organ-specific manner."
15487a20818,20820
> "Q9QZ05-1","RefSeq","NP_038747.2","29660505","Our data provide solid evidence that GCN2 has a marked effect on Dox induced myocardial apoptosis and oxidative stress. Our findings suggest that strategies to inhibit GCN2 activity in cardiomyocyte may provide a novel approach to attenuate Dox-related cardiotoxicity."
> "Q9QZ05-1","RefSeq","NP_038747.2","29337352","This study demonstrated that the phosphorylation of translational elongation factor eEF2 as a molecular mechanism underlying mTORC1-independent L-LTP in PERK KO mice."
> "Q9QZ05-1","RefSeq","NP_038747.2","11106749","Regulated translation initiation controls stress-induced gene expression in mammalian cells"
15493a20827,20832
> "Q8CJ53-1","RefSeq","NP_598886.1","28720386","CIP4 silencing can efficiently alleviate Streptozotocin-induced pulmonary fibrosis in mice, perhaps through suppressing Wnt/GSK-3beta/beta-catenin signaling."
> "Q8CJ53-1","RefSeq","NP_598886.1","23881916","CIP4 is a new component in the highly coordinated system of megakaryocytic membrane and cytoskeletal remodeling affecting platelet production."
> "Q8CJ53-1","RefSeq","NP_598886.1","23572514","CIP4 coordinates with phospholipids and actin-associated proteins to localize to the protruding edge and produce actin ribs and veils."
> "Q8CJ53-1","RefSeq","NP_598886.1","22920438","Data suggest that down-regulation of CIP4 in osteosarcoma changes cell morphology (reduces actin; alters cytoskeleton), inhibits primary tumor growth, impairs invasiveness and migration of tumor cells, delays metastasis, and prolongs survival time."
> "Q8CJ53-1","RefSeq","NP_598886.1","22361215","In primary cortical neurons CIP4 is concentrated specifically at the tips of extending lamellipodia and filopodia, instead of endosomes as in other cell types."
> "Q8CJ53-1","RefSeq","NP_598886.1","12054674","Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms (CIP4)"
15501a20841,20844
> "Q9Z239-1","RefSeq","NP_919302.1","29902467","Authors studied the male progeny of Fxyd1 null males bred to heterozygous Mecp2 female mice. Maximal NKA enzymatic activity was not altered by the loss of MeCP2, but it increased in mice lacking one Fxyd1 allele, suggesting that NKA activity is under Fxyd1 inhibitory control."
> "Q9Z239-1","RefSeq","NP_919302.1","29155857","It was proposed that FXYD1 plays a role in regulating AQP2 retention in apical membrane, and that this involves transfers between raft-like membrane domains in endosomes and plasma membranes. Publication Status: Online-Only"
> "Q9Z239-1","RefSeq","NP_919302.1","16002746","PLM modulates the NKA function in a manner similar to the way phospholamban affects the related SR Ca-ATPase (inhibition of transport substrate affinity, that is relieved by phosphorylation)."
> "Q9Z239-1","RefSeq","NP_919302.1","15563542","A primary effect of phospholemman is to modulate the Na-K-ATPase and that its reduced activity initiates compensatory responses in heart hypertrophy"
15503a20847
> "Q8BII1-1","RefSeq","NP_780407.1","16470382","Compared to mouse Prox1, mouse Prox2 is dispensable for embryonic development, retinal horizontal cell generation, and fertility."
15507,15508c20851,20853
< "Q8BP97-1","RefSeq","NP_001277421.1","24859449","Report that Rhbdd3, a member of the rhomboid family of proteases, suppressed the activation of dendritic cells and production of interleukin 6 (IL-6) triggered by Toll-like receptors"
< "Q8BP97-1","RefSeq","NP_001277421.1","23610400","Rhbdd3 is a feedback inhibitor of TLR3-triggered NK cell activation"
---
> "Q8K2K6-4","RefSeq","NP_034602.1","18775314","Study demonstrates that the clathrin-mediated endocytosis of the SNARE VAMP7 is directly mediated by Hrb, a clathrin adaptor and ArfGAP."
> "Q8K2K6-4","RefSeq","NP_034602.1","14724135","Lack of an acrosome in Hrb mutant spermatids does not prevent the development of the acroplaxome. In the Hrb mutant, myosin-Va-bound proacrosome vesicles tether to the acroplaxome, where they flatten and form a flat sac, designated pseudoacrosome."
> "Q8K2K6-4","RefSeq","NP_034602.1","11711676","Required for docking and/or fusion of proacrosomic vesicles during acrosome biogenesis"
15509a20855
> "Q8BIH0-1","RefSeq","NP_766553.1","29355515","Interaction between Mincle and SAP130 may promote the progression of alcoholic liver disease by IL-1beta production in Kupffer cells and consequently increase inflammatory immune cell infiltration."
15510a20857,20858
> "Q9CXL7-1","RefSeq","NP_082749.1","28323137","Snorc is expressed postnatally in knee epiphyses especially by prehypertrophic chondrocytes delineating the cartilage canals and secondary ossification center. Snorc core protein binds to FGF2 and inhibits FGF2 dependent cell growth of C3H101/2 cells. In Snorc deficient mice, Snorc deficiency caused defects in secondary ossification and growth plate maturation associated with increased Ihh and reduced MMP13 expression."
> "Q9CXL7-1","RefSeq","NP_082749.1","21624478","A novel cartilage-specific molecule, Snorc, was identified that may have functions associated with development and maintenance of chondrocyte phenotype"
15521a20870
> "Q499E0-1","RefSeq","NP_705767.3","22245424","FAM5C might be an important humoral bone anabolic factor produced from muscle cells."
15522a20872
> "P58545-1","RefSeq","NP_663509.2","24179155","During the development of the sensory cortex, dendritic field orientation is controlled by the BTB/POZ domain-containing 3 (BTBD3)."
15533a20884,20889
> "Q64327-1","RefSeq","NP_034917.1","15051958","A comparative expression study of Mea1 and the B56delta subunit of protein phosphatase 2A in spermatogenesis."
> "Q64327-1","RefSeq","NP_034917.1","12444059","Localization of the male-enhanced antigen-1 suggests that it may function in the very late stages of spermiogenesis"
> "Q9D659-1","RefSeq","NP_083008.1","29267882","The results suggest that VISTA is involved in the regulation of Th2 cell generation and Th2 cell-mediated antibody production and regulates asthmatic responses, especially in the effector phase."
> "Q9D659-1","RefSeq","NP_083008.1","29216931","VISTA expression supports immune-complex inflammation in collagen antibody-induced arthritis and VISTA is expressed in human synovium Publication Status: Online-Only"
> "Q9D659-1","RefSeq","NP_083008.1","28729608","Our results indicate that PD-1H is required for maintenance of iTreg pool size by promoting its differentiation and preventing its conversion to other CD4(+) T cell subsets. These findings may have important implications for manipulating Tregs to control inflammation. Publication Status: Online-Only"
> "Q9D659-1","RefSeq","NP_083008.1","20042595","Results demonstrate that Dies1 is required for BMP4/Smad1 signaling cascade. GeneRIF: Dies1 is a necessary factor of BMP4 signaling and its suppression sustains mESC self-renewal."
15535a20892
> "A2AHC3-1","RefSeq","NP_001263290.1","22095662","Camsap1-expressing cells exhibit regional heterogeneity in an early phase after stab injury of mouse brain.  Newly born reactive astrocytes are derived from heterogeneous Camsap1-expressing cells in the injured brain."
15539a20897,20899
> "P63075-1","RefSeq","NP_032030.1","9651520","The expression from early streak stage to midgestation of Fgf17 is measured.  It is closely related to Fgf8 (63.7% identical at the amino acid level). Fgf17 is expressed during gastrulation but at lower levels than Fgf8."
> "P28741-1","RefSeq","NP_032469.2","30148884","Study demonstrates that the non-canonical SMO/Gi/RHOA pathway functions outside primary cilia: Kif3a-deficient fibroblasts, unable to form primary cilia and to activate the canonical Hedgehog pathway, can activate RHOA robustly after stimulation of endogenous SMO with SHH or purmorphamine, and that KIF3A re-expression rescues ciliogenesis but does not affect RHOA activation. Publication Status: Online-Only"
> "P28741-1","RefSeq","NP_032469.2","29156524","KIF3A plays an important role in epithelium apoptosis and bronchial inflammation in asthma"
15552,15556d20911
< "Q9WVQ1-1","RefSeq","NP_001164217.1","28539383","In summary,MAGI-2 and Fyn protect dendrin fromNedd4-2-mediated ubiquitination and from nuclear translocation, thereby maintaining the physiologic homeostasis of podocytes, and the lack of MAGI-2 in podocytes results in FSGS."
< "Q9WVQ1-1","RefSeq","NP_001164217.1","25993318","Magi2 is an essential component of the slit diaphragm complex that is required for nephrin localization and foot process formation."
< "Q9WVQ1-1","RefSeq","NP_001164217.1","25653350","Elevation of S-SCAM expression in the excitatory neurons of forebrain was sufficient to induce an schizophrenia-like phenotype in mice."
< "Q9WVQ1-1","RefSeq","NP_001164217.1","25271328","MAGI-2 is required for the integrity of the kidney filter and podocyte survival."
< "Q9WVQ1-1","RefSeq","NP_001164217.1","14750953","Localization of synaptic scaffolding molecule (S-SCAM) at the puncta adherentia junctions formed between the mossy fibre terminals and the dendrites of CA3 pyramidal cells."
15561a20917,20918
> "E9Q5C9-1","RefSeq","NP_444316.2","28493459","Enhanced NOLC1 promotes cell senescence and represses hepatocellular carcinoma cell proliferation by disturbing the organization of nucleolus."
> "E9Q5C9-1","RefSeq","NP_444316.2","26984997","UBF and Nopp140 dynamic redistribution between the two-cell and blastocyst stages (time of implantation) is correlated with morphological and structural modifications that occur in embryonic nucleolar compartments."
15565,15568c20922,20931
< "Q6P069-1","RefSeq","NP_001074443.1","29273681","Sorcin is involved in the regulation of Ca(+2)-mediated angiogenesis via VEGF/PI3K/Akt pathway in endometrial cells."
< "Q6P069-1","RefSeq","NP_001074443.1","29174767","Sorcin deficiency may trigger cardiac ventricular arrhythmias due to Ca(2+) disturbances"
< "Q6P069-1","RefSeq","NP_001074443.1","26822088","Sorcin links pancreatic beta cells lipotoxicity to calcium stores and provides a target for intervention in type 2 diabetes."
< "Q6P069-1","RefSeq","NP_001074443.1","12824171","Sorcin is a potent inhibitor of both spontaneous and ICa-triggered RyR activity and is kinetically capable of playing a role in terminating the positive feedback loop of Ca2+-induced Ca2+ release"
---
> "P39053-1","RefSeq","NP_034195.2","30381405","The present work with dyn1-KO mice further confirms that Ca(2+)-dependent transmitter release is mainly via subquantal mode, suggesting that subquantal release could be also important in other types of cells"
> "P39053-1","RefSeq","NP_034195.2","29800726","Cellular fluorescein hyperfluorescence is dynamin-dependent."
> "P39053-1","RefSeq","NP_034195.2","28853753","Dynamin is a molecular motor which would be involved in GLUT4 translocation by facilitating exocytosis"
> "P39053-1","RefSeq","NP_034195.2","20700442","Missense mutation in conserved alternate exon of dynamin-1 causes epilepsy in a mouse model. Publication Status: Online-Only"
> "Q9D658-1","RefSeq","NP_033001.2","29746167","Chemical and biologic reagents reveal a previously unknown communication between the intracellular PTP4A3 phosphatase and the ECM and support efforts to pharmacologically target PTP4A3."
> "Q9D658-1","RefSeq","NP_033001.2","27124574","Our results suggest that the Prl3b1-cre mice line provides a unique resource to understand testicular germ-cell development"
> "Q9D658-1","RefSeq","NP_033001.2","25139404","PRL-3 protein was significantly reduced in mouse STAT3-knockout liver cells compared with STAT3-wild type counterparts, and ectopic expression of STAT3 in these cells led to a pronounced increase in PRL-3 protein."
> "Q9D658-1","RefSeq","NP_033001.2","24950307","Results demonstrate that Ptp4a3 contributes to the malignant phenotype of tumor-initiating cells."
> "Q9D658-1","RefSeq","NP_033001.2","24909283","Data indicate that Mycobacterium tuberculosis T cell stimulatory epitope (MT) is a potentially effective molecular adjuvant in preparation of monoclonal antibody (mAb) specific for phosphatase of regenerating liver-3 (PRL-3)."
> "Q9D658-1","RefSeq","NP_033001.2","15161639","PRL-3 was highly expressed in metastatic melanoma B16-BL6 cells but not in its lowly metastatic parental cell line, B16 cells"
15570,15572c20933
< "P54310-1","RefSeq","NP_001034596.1","30086728","Studied role of hormone-sensitive lipase (HSL) in adipose tissue and pancreatic inflammation, and found HSL deficiency hastens is associated with adipose tissue and pancreatic inflammation, and development of pancreatic ductal adenocarcinoma in a transgenic mouse model. Publication Status: Online-Only"
< "P54310-1","RefSeq","NP_001034596.1","29232702","HSL-deficient mice revealed a complex interorgan interaction between adipose tissue and liver: the role of HSL in the liver is minimal but adipose tissue deficiency of HSL can cause age-dependent hepatic steatosis Publication Status: Online-Only"
< "P54310-1","RefSeq","NP_001034596.1","28851734","Cardiac PLIN2 plays an important pathophysiological role in the development of dynamic steatosis and that the latter was prevented by upregulation of intracellular lipases, including Hormone-sensitive Lipase."
---
> "Q9CXC3-1","RefSeq","NP_083260.1","29572490","MGME1 is part of a termination complex acting at the end of the D-loop region where it modulates mtDNA replication and H-strand transcription termination. Mice with MGME1 deficiency accumulate a long linear subgenomic mtDNA species, but do not develop progeria. Publication Status: Online-Only"
15576,15578d20936
< "Q6GQT0-1","RefSeq","NP_001074287.1","29293958","CDC14A activity is necessary for hearing and male fertility."
< "Q6GQT0-1","RefSeq","NP_001074287.1","26283732","Cdc14B knockout (Cdc14B(-/-)) mouse embryonic fibroblasts showed defects in repairing ionizing radiation-induced DNA double-strand breaks, which occurred only at late passages when Cdc14A levels were low."
< "Q6GQT0-1","RefSeq","NP_001074287.1","19270517","CDC14A regulates oocyte maturation and functions to promote the meiosis I-to-meiosis II transition as its homolog does in budding yeast."
15588a20947,20953
> "Q99ME3-1","RefSeq","NP_001186082.1","30966771","Intracytoplasmic Lewy bodies are primarily composed of the protein alpha-synuclein which increases in substantia nigra of Parkinson's disease."
> "Q99ME3-1","RefSeq","NP_001186082.1","29747690","This study showed that A53T-alpha-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia. Publication Status: Online-Only"
> "Q99ME3-1","RefSeq","NP_001186082.1","29124353","The finding of increased spine pathology in Thy1-E57K is a new pathogenic function of oligomeric a-syn and precedes overt neurodegeneration. Thus, it may constitute a readout for therapeutic approache."
> "Q99ME3-1","RefSeq","NP_001186082.1","28870519","Enhanced aggregation and phosphorylation of alphaSyn causes the loss of dopaminergic neurons leading to the decline of motor coordination."
> "Q99ME3-1","RefSeq","NP_001186082.1","28621812","2,3,7,8-tetrachlorodibenzo-p-dioxin promoted synphilin-1 degradation in an aryl hydrocarbon receptor-dependent way."
> "Q99ME3-1","RefSeq","NP_001186082.1","19760259","Synphilin-1 has a role in skill learning and motor performance"
> "Q99ME3-1","RefSeq","NP_001186082.1","19857556","Expression of synphilin-1 shortens N1E-115 cell division doubling time, promotes neurite outgrowth, and protects against Rotenone-induced toxicity; synphilin-1 displays a neurotrophic effect in vitro, may play a neuroprotective role in Parkinson's disease"
15590a20956,20960
> "Q9DCP2-1","RefSeq","NP_076294.2","30634395","The results demonstrate the regulatory role of Sp1 in regulation of SN1 expression and activity in ammonia-treated astrocytes and implicate altered Sp1 phosphorylation status in this capacity. Publication Status: Online-Only"
> "Q9DCP2-1","RefSeq","NP_076294.2","29561757","This indicates a role for PKC in dynamically controlling the trafficking of SNAT3 transporters in astrocytes in situ. Publication Status: Online-Only"
> "Q9DCP2-1","RefSeq","NP_076294.2","26490457","SNAT3 is required for amino acid homeostasis and determines critical functions in various organs. Loss of Snat3 cannot be compensated."
> "Q9DCP2-1","RefSeq","NP_076294.2","25116356","Acid loading increased urinary ammonium excretion in all groups, but to a lesser extent in the O-GI group. SNAT3 mRNA expression was enhanced in both obese groups"
> "Q9DCP2-1","RefSeq","NP_076294.2","24854847","Regulation of SNAT3 gene expression by extracellular pH involves post-transcriptional and transcriptional mechanisms, the latter being distinct from the mechanisms that control the tissue-specific expression of the gene"
15592d20961
< "Q9CQA0-1","RefSeq","NP_079915.1","12881717","A new 20 kDa protein (PANE1) induced upon transdifferentiation was nuclear in nonconfluent cells and cytoplasmic in confluent or dividing cells."
15596c20965,20971
< "Q3UZ01-1","RefSeq","NP_001033785.1","30254136","Our study, using a novel conditional mouse model of Rnpc3 deficiency, establishes that U12-dependent splicing is not only important during development but is indispensable throughout life."
---
> "Q640M6-1","RefSeq","NP_958740.2","28103900","GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord Publication Status: Online-Only"
> "Q640M6-1","RefSeq","NP_958740.2","23589856","Posttranslational modifications increase glycerophosphocholine by inhibiting GDPD5 phosphodiesterase."
> "Q640M6-1","RefSeq","NP_958740.2","22951639","A key role for Gde2 in controlling cortical neuronal fates by regulating the timing of neurogenesis, and loss of Gde2 uncovers additional mechanisms that trigger remaining neuronal progenitors to differentiate at the end of the neurogenic period."
> "Q640M6-1","RefSeq","NP_958740.2","21943603","Data suggest that neuronal GDE2 controls motor neuron subtype diversity through a non-cell-autonomous feedback mechanism that directly regulates progenitor cell differentiation."
> "Q640M6-1","RefSeq","NP_958740.2","19766572","Study identified the antioxidant enzyme Prdx1 as an interactor of GDE2 and uncover a developmental role for Prdx1 in regulating neuronal differentiation in the spinal cord."
> "Q640M6-1","RefSeq","NP_958740.2","18667693","GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte glycerophosphocholine."
> "Q640M6-1","RefSeq","NP_958740.2","17275818","These results demonstrate that GDE2 expression during neuronal differentiation plays an important role for growing neurites."
15610c20985,20989
< "Q5D525-1","RefSeq","NP_001041610.1","16328886","An isoform of 4930481F22, lacking the 7th exon, encodes a putative 28.4 kDa protein expressed in spermatocytes, and may have an important role in meiosis."
---
> "Q9Z103-1","RefSeq","NP_033758.2","30664622","The Adnp haploinsufficient mouse mimics the human ADNP syndrome in terms of synapse density and gene expression patterns, as well as in developmental, motor, and cognitive abilities. Publication Status: Online-Only"
> "Q9Z103-1","RefSeq","NP_033758.2","30008470","Excessive alcohol consumption in female mice led to long-lasting reduction in hippocampal Adnp expression. We found that Adnp haploinsufficient female mice showed higher alcohol consumption and preference, compared to Adnp intact females, whereas no genotype difference was observed in males."
> "Q9Z103-1","RefSeq","NP_033758.2","30106381","Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome."
> "Q9Z103-1","RefSeq","NP_033758.2","29795351","Results reveal that ADNP, via the recruitment of HP1 and CHD4, regulates the expression of genes that are crucial for maintaining distinct cellular states and assures accurate cell fate decisions upon external cues"
> "Q9Z103-1","RefSeq","NP_033758.2","12888219","ADNP is identified as a new key gene essential for organogenesis in the developing embryo and may be implicated as a clinical target associated with proper neurodevelopment."
15617a20997,21002
> "Q3U507-1","RefSeq","NP_001171253.1","29457279","Lysophosphatidyl serine acts via GPR174 and Galphas to suppress IL-2 production by activated T cells"
> "Q3U507-1","RefSeq","NP_001171253.1","26077720","The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function."
> "G3X9I0-1","RefSeq","NP_033570.2","20186958","Results suggest that ZFP105 is a male germ-cell factor and plays a role in male reproduction."
> "Q9Z1B3-1","RefSeq","NP_062651.2","27776973","Plcb1 plays a crucial role in the initiation of the genetic program responsible for muscle differentiation and osteogenesis. (Review) Review article"
> "Q9Z1B3-1","RefSeq","NP_062651.2","27563828","Data show that phospholipase C (PLC)-beta1 (PLC-beta1) overexpression determines an increase in beta-catenin translocation and that PLC-beta1, inositol polyphosphate multikinase (IPMK) and beta-catenin are mediators of the same signaling pathway."
> "Q9Z1B3-1","RefSeq","NP_062651.2","27342861","Functions in plasma membrane remodeling, particularly caveolae formation"
15621a21007
> "O54909-1","RefSeq","NP_033066.1","15355969","Rdh1, Crad1, and other short-chain dehydrogenases/reductases, which share similar N-terminal signaling sequences such as human Rdh5 and mouse Rdh4, orient with their catalytic domains facing the cytoplasm"
15625a21012,21019
> "A0A0G2JDV3-1","RefSeq","NP_919317.2","21551061","Findings show that at least 4 IFN-gamma-inducible Gbps--Gbp1, Gbp6, Gbp7, and Gbp10--conferred cell-autonomous immunity to listerial or mycobacterial infection within macrophages and gene-deficient animals"
> "Q9Z282-1","RefSeq","NP_064309.1","30327654","G2A is necessary to position macrophages in the proinflammatory microenvironment surrounding the center of inflammation. In absence of G2A the macrophages are localized in an antiinflammatory microenvironment and macrophage polarization is shifted toward M2-like macrophages. Publication Status: Online-Only"
> "Q9Z282-1","RefSeq","NP_064309.1","30139917","GPR132 responds to a select panel of oxygenated polyunsaturated fatty acids to enhance both embryonic and adult hematopoiesis."
> "Q9Z282-1","RefSeq","NP_064309.1","29159784","G2A overexpression reduced the infiltration of granulocytes and attenuated hyperalgesia after CFA injection. G2A knockdown increased the number of immune cells before CFA injection and prolonged the inflammatory hyperalgesia."
> "Q9Z282-1","RefSeq","NP_064309.1","28049847","Lactate activates macrophage Gpr132 to promote the alternatively activated macrophage (M2)-like phenotype, which, in turn, facilitates cancer cell adhesion, migration, and invasion. Consequently, Gpr132 deletion reduces M2 macrophages and impedes breast cancer lung metastasis in mice."
> "Q9Z282-1","RefSeq","NP_064309.1","27692066","The authors report that macrophage PPARgamma deletion in mice not only exacerbates mammary tumor development but also impairs the anti-tumor effects of rosiglitazone. Mechanistically, the authors identify Gpr132 as a novel direct PPARgamma target in macrophage whose expression is enhanced by PPARgamma loss but repressed by PPARgamma activation. Publication Status: Online-Only"
> "Q9Z282-1","RefSeq","NP_064309.1","14681556","Role of G2A in lysophosphatidylcholine-mediated T-cell migration"
> "Q9Z282-1","RefSeq","NP_064309.1","12482833","G2A is expressed predominantly by macrophages within atherosclerotic lesions at the aortic root of apolipoprotein E-deficient mice."
15630c21024,21032
< "Q60682-1","RefSeq","NP_001095090.1","27831490","Furthermore, Ly49/MHC-I interactions are diffusion-controlled and enthalpy-driven."
---
> "Q91WG8-1","RefSeq","NP_056643.3","23842869","GNE is a master regulator of sialic acid synthesis in the vertebrates. (Review) Review article"
> "Q91WG8-1","RefSeq","NP_056643.3","23266873","Analysis of differential Gne transcript expression of the two splice variants, Gne1 and Gne2."
> "Q91WG8-1","RefSeq","NP_056643.3","11929971","Inactivation of the UDP-GlcNAc 2-epimerase by gene targeting causes early embryonic lethality in mice, thereby emphasizing the fundamental role of this bifunctional enzyme and sialylation during development"
> "Q2PFD7-1","RefSeq","NP_808366.2","27241101","Genetic variants of EFA6D were found to be distributed in overlapping patterns throughout the subcellular brain."
> "Q0KL02-1","RefSeq","NP_001074771.1","30463880","Cdh2 signaling via Trio assembles adherens junctions to restrict endothelial permeability."
> "Q0KL02-1","RefSeq","NP_001074771.1","30268758","To study the underlying mechanism, we investigated the p38 MAPK pathway and found that loss of Trio blocked the cascade transduction of p38 MAPK signaling. In conclusion, we identified Trio as a novel coordinator in regulating root development and clarified its relevant molecular events."
> "Q0KL02-1","RefSeq","NP_001074771.1","30177526","Trio induces RhoA activation downstream of Slit2, and support a functional role in ensuring the proper positioning of both guidepost cells and a major axonal tract. Publication Status: Online-Only"
> "Q0KL02-1","RefSeq","NP_001074771.1","28973398","Genetic damage to both TGEF domains altered TRIO catalytic activity, decreasing TGEF1 activity and increasing TGEF2 activity."
> "Q0KL02-1","RefSeq","NP_001074771.1","17332503","M-cadherin-dependent adhesion can activate Rac1 via the Rho-GEF Trio at the time of myoblast fusion."
15636,15638c21038,21041
< "Q9D2G5-1","RefSeq","NP_001106823.1","27878645","Report showing expression, location and isoforms of Synj1 and Synj2 in the small and large intestine and that they might participate in intestinal pathology."
< "Q9D2G5-1","RefSeq","NP_001106823.1","24103750","Clustering all known mouse Synj2 transcripts led to uncover a novel subset of transcripts that appears to derive from a region located within intron 7."
< "Q9D2G5-1","RefSeq","NP_001106823.1","21423608","These results reveal Synj2 as a critical regulator of hair cell survival that is essential for hair cell maintenance and hearing function. Publication Status: Online-Only"
---
> "Q6PHZ8-1","RefSeq","NP_084541.3","23457522","Genome-wide association study identifies KCNIP4 as an asthma gene in human and in mouse."
> "Q6PHZ8-1","RefSeq","NP_084541.3","20550899","KChIP4a functions to promote tetrameric assembly and enhance surface expression of Kv4 channels."
> "Q6PHZ8-1","RefSeq","NP_084541.3","20045463","These data demonstrate that PKA phosphorylation of Kv4.2 plays an important role in the trafficking of Kv4.2 through its specific interaction with KChIP4a."
> "Q6PHZ8-1","RefSeq","NP_084541.3","15363885","KChIP4 was highly expressed by neurons in layers II-IV of cortex and in hippocampus, thalamus and the Purkinje cell layer of the cerebellum."
15645a21049,21062
> "Q6NZQ8-1","RefSeq","NP_780397.2","30356278","Results show that MARCH1 deficiency results in sex-specific changes in body weight, adiposity, and increases glucose clearance. Genetic association study for MARCH1 in type 2 diabetes risk in publicly-available datasets found evidence suggestive of association. These data show a link between immune function and diabetes implicating MARCH1 as a regulator of lipid metabolism and glucose tolerance in sex-specific manner. Publication Status: Online-Only"
> "Q6NZQ8-1","RefSeq","NP_780397.2","30154416","Study shows march1-dependent modulation of donor MHC II on CD103(+) dendritic cells mitigates alloimmunity Publication Status: Online-Only"
> "Q6NZQ8-1","RefSeq","NP_780397.2","30001419","Unexpected intersection between MHC I and MHC II such that the surface expression of both molecules are indirectly and directly regulated by MARCH1 ubiquitination, respectively. Publication Status: Online-Only"
> "Q6NZQ8-1","RefSeq","NP_780397.2","29854835","These results demonstrate a role of March1 E3 ubiquitin ligase in modulating allergic responses Publication Status: Online-Only"
> "Q6NZQ8-1","RefSeq","NP_780397.2","29378848","Found downstream sequence elements, present in the first coding exon of March-I in antigen-presenting cells (APCs), that confer regulation of March-I expression in activated APCs"
> "Q6NZQ8-1","RefSeq","NP_780397.2","21220452","Found that the transmembrane domain of CD83 enhances MHC class II and CD86 expression by blocking MHC class II association with the ubiquitin ligase MARCH1"
> "Q6NZQ8-1","RefSeq","NP_780397.2","21059907","Selective ubiquitination of MHC-II in immature dendritic cells by the E3 ubiquitin ligase March-I results in the selective degradation of internalized pMHC-II."
> "Q6NZQ8-1","RefSeq","NP_780397.2","19917682","MARCH-I may function as a housekeeper of conventional dendritic cell in the steady state."
> "Q6NZQ8-1","RefSeq","NP_780397.2","19880452","MARCH1 expression is regulated at a posttranscriptional level by trafficking within the endolysosomal pathway where MARCH1 is proteolyzed."
> "Q6NZQ8-1","RefSeq","NP_780397.2","17255932","The function of MHC II in B cells is regulated through ubiquitination by MARCH-I."
> "Q9CYR0-1","RefSeq","NP_997633.1","30369577","SSBP1 was down-regulated by Angiotensin II and implicated in cardiac fibrosis through fibroblast proliferation and collagen expression partly via the p53 protein."
> "Q9CYR0-1","RefSeq","NP_997633.1","23459151","SSBp1 deletion results in increased chromosomal aberrations and localizes to telomeres and participate in the repair of uncapped telomeres."
> "Q9CYR0-1","RefSeq","NP_997633.1","21048415","Plays a role in the regulation of mitochondrial morphology. (review)"
> "Q9CYR0-1","RefSeq","NP_997633.1","16860483","Overexpression of Mitogenin I or mitochondrial single-stranded DNA-binding protein increased elongated or fragmented mitochondria in mouse C2C12 myoblast cells, respectively."
15651a21069,21072
> "Q9EPK6-1","RefSeq","NP_109674.2","29718201","The protein but not the mRNA level of ORP150, a nucleotide exchange factor which can substitute for SIL1, was increased in the cerebellum of GSK2606414-treated woozy mice, suggesting that translational recovery promoted the synthesis of this alternative BiP co-factor"
> "Q9EPK6-1","RefSeq","NP_109674.2","29666155","These data reveal a disruption in endoplasmic reticulum homeostasis upon SIL1 loss, which is countered by multiple compensatory responses that are ultimately unsuccessful, leading to trans-organellar proteostasis collapse and myopathy. Publication Status: Online-Only"
> "Q9EPK6-1","RefSeq","NP_109674.2","28723727","The carry a mutation in the Sil1 gene mice showed adult-onset ataxia with progressive neurodegeneration of the cerebellum. Homozygous wz mice might be useful as an animal model of diseases showing adult-onset ataxia because of cerebellar neurodegeneration."
> "Q9EPK6-1","RefSeq","NP_109674.2","25575678","These results suggested the important roles of endoplasmic reticulum-related chaperons, Bip and SIL1, in Alzheimer's disease-like tau hyperphosphorylation."
15654a21076,21078
> "Q8VCX2-1","RefSeq","NP_659142.1","20837470","Data show that Slc35c2 enhances fucosylation of Notch1."
> "P21570-1","RefSeq","NP_031473.1","27518564","ANG plays a non-cell-autonomous role in regulation of hematopoiesis by simultaneously preserving hematopoietic stem/progenitor cells stemness and promoting myeloid-restricted progenitor cell proliferation."
> "P21570-1","RefSeq","NP_031473.1","15722482","RNase 4 and RNase 5/ang 1 are unique among the RNase A ribonuclease genes in that they maintain a complex gene locus that is conserved across species with transcription initiated from tissue-specific dual promoters followed by differential exon splicing. Publication Status: Online-Only"
15663a21088,21089
> "Q8C8R3-1","RefSeq","NP_848770.2","29720258","These findings reveal spectrin (alpha/beta) / ankyrin B cytoskeletal and signaling proteins as key regulators of T-type calcium channels expressed in the nervous system. Publication Status: Online-Only"
> "Q8C8R3-1","RefSeq","NP_848770.2","29133412","Cell-autonomous adiposity results from increased cell surface GLUT4 due to ankyrin-B deficiency in humans and mice."
15664a21091,21094
> "P63280-1","RefSeq","NP_035795.1","30375383","SUMO-conjugating enzyme Ubc9 interacts with a conserved GKAE motif in ROR-gammat to induce SUMOylation of ROR-gammat and suppress IL-17 expression. Publication Status: Online-Only"
> "P63280-1","RefSeq","NP_035795.1","29472640","Ubc9 transgenic mice, but also SUMO1 knockout mice were protected from ischemia/reperfusion injury as evidenced by better preserved barrier function and blunted inflammatory responses"
> "P63280-1","RefSeq","NP_035795.1","28314856","This study shows that loss of Ubc9 results in a significant reduction of CD4 and CD8 single-positive lymphocytes in both thymus and periphery"
> "P63280-1","RefSeq","NP_035795.1","28143738","These findings suggest that the UBC9/PML/RNF4 axis plays a critical role as an important SUMO pathway in cardiac fibrosis. Modulating the protein levels of the pathway provides an attractive therapeutic target for the treatment of cardiac fibrosis and heart failure."
15669a21100,21105
> "Q6SJQ7-1","RefSeq","NP_663609.2","30479367","LMIR3-knockout neutrophils displayed significantly augmented cytotoxic activity against P. aeruginosa and C. albicans. LMIR3 expression increased in response to infection in a TLR4/MyD88-dependent manner. Publication Status: Online-Only"
> "Q6SJQ7-1","RefSeq","NP_663609.2","30127493","Although the serine palmitoyltransferase complex is dispensable for the surface expression of the norovirus receptor (CD300lf), enzyme activity is required for CD300lf to adopt a conformation permissive for viral binding. Addition of extracellular ceramide to serine palmitoyltransferase-deficient cells complements both the conformational changes of CD300lf and the cellular susceptibility to murine norovirus infection."
> "Q6SJQ7-1","RefSeq","NP_663609.2","30194229","Docking of the cocomplex structures onto a cryo-EM-derived model of MNoV suggests that each virion can make multiple CD300lf engagements, and thus, infection may be driven by the avidity of cell surface clustered CD300lf."
> "Q6SJQ7-1","RefSeq","NP_663609.2","18097021","These results indicate that CD300LF mediates caspase and endoplasmic reticulum stress-independent cell death by a novel mechanism."
> "Q6SJQ7-1","RefSeq","NP_663609.2","17438331","The innate immune system is at least in part regulated by the qualitative and quantitative balance of the paired receptors LMIR3 and LMIR4"
> "Q6SJQ7-1","RefSeq","NP_663609.2","16794255","DIgR2 is a functionally inhibitory receptor and can mediate negative signaling to regulate DC-initiated antigen-specific T-cell responses."
15671,15674c21107,21109
< "P30875-1","RefSeq","NP_001036071.1","30261745","SSTR2 is mainly expressed in distal tubules and collecting ducts in murine kidneys, and the expression of SSTR2 decreases during cyst growth in two polycystic kidney disease mouse models"
< "P30875-1","RefSeq","NP_001036071.1","29409919","Unpredictable chronic mild stress (UCMS) caused neuroendocrine changes, physical deteriorations, increased anxiety- and depressive-like behaviors and working memory impairments. sst2KO mice displayed behavioral alterations which were similar to stressed WT and exhibited exacerbated changes following UCMS exposure. The evaluations performed in the older mice showed significant long-term effects of UCMS exposure."
< "P30875-1","RefSeq","NP_001036071.1","27986975","Both hippocampal sst2 and sst4 receptors selectively inhibit stress-induced HPA axis activation but mediate anxiolytic and antidepressive effects through distinct mechanisms."
< "P30875-1","RefSeq","NP_001036071.1","25683115","Loss of sst2 from pancreatic tissues activates PI3K signaling via AKT, leading to activation of NF-kappaB, amplification of oncogenic KRAS signaling, increased expression of CXCL16, and pancreatic tumor formation."
---
> "Q05685-1","RefSeq","NP_032061.1","27122634","The characteristics of folate transport in oocytes are consistent with folate receptor-mediated endocytosis, possibly by the FOLR2 isoform."
> "Q05685-1","RefSeq","NP_032061.1","25375039","FRbeta expression was markedly increased in lung macrophages at 48 hours after intratracheal LPS."
> "Q05685-1","RefSeq","NP_032061.1","23904512","The mRNAs encoding Folr2 and the intestinal folate transporter Slc46a1 were not detected in 2-cell embryos and blastocysts. Publication Status: Online-Only"
15680a21116
> "P25085-1","RefSeq","NP_112444.1","29891552","These data reveal that IL-1Ra and IL-36Ra have opposing effects on the outcome of Pseudomonas aeruginosa keratitis"
15684a21121,21124
> "P70372-1","RefSeq","NP_034615.2","31103627","HuR regulates Paneth cell function by modulating TLR2 localization via posttranscriptional control of CNPY3 expression."
> "P70372-1","RefSeq","NP_034615.2","31147543","Compared with control mice, HuR(AKO) mice show obesity when induced with a high-fat diet, along with insulin resistance, glucose intolerance, hypercholesterolemia and increased inflammation in adipose tissue. The obesity of HuR(AKO) mice is attributed to adipocyte hypertrophy in white adipose tissue due to decreased expression of adipose triglyceride lipase (ATGL). HuR positively regulates ATGL expression. Publication Status: Online-Only"
> "P70372-1","RefSeq","NP_034615.2","30340104","This study shows that endothelial HuR deletion reduces the expression of proatherogenic molecules and attenuates atherosclerosis"
> "P70372-1","RefSeq","NP_034615.2","30532756","Study demonstrates that epithelial and myeloid HuR affect different cellular dynamics in the intestine that need to be carefully considered for its pharmacological exploitation and points toward potential windows for harnessing HuR functions in intestinal inflammation. Publication Status: Online-Only"
15689a21130
> "Q6P9N8-1","RefSeq","NP_765994.2","22569362","Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro 1/2 and Trak2. Publication Status: Online-Only"
15694a21136
> "Q5GH62-1","RefSeq","NP_001011873.1","25231987","Unlike Xkr8, which is ubiquitously expressed, Xkr4 and Xkr9 expression is tissue-specific."
15709a21152,21161
> "Q810J8-1","RefSeq","NP_898977.2","25876663","Endogenous DFCP1 was preferentially associated with mitochondria rather than with the Golgi apparatus or the endoplasmic reticulum in Hela cells."
> "Q8R5M8-1","RefSeq","NP_997559.1","12202822","SynCAM1 is expressed in brain and localized to pre- and postsynaptic sites of neurons.  SynCAM1 is a homophilic cell adhesion molecule that induces formation of presynaptic terminals by neurons."
> "Q8R5M8-1","RefSeq","NP_997559.1","12242005","The Tslc1 gene is mapped on mouse chromosome 9, a synteny of human chromosome 11q, and is composed of ten exons, the exon-intron junctions being highly conserved between human and mouse."
> "Q9D3E6-1","RefSeq","NP_033308.2","25735743","Reduced dosage of SA1 altered the architecture of the Reg locus and decreased the expression of Reg genes in the pancreas of SA1 heterozygous mice"
> "Q9CZW6-1","RefSeq","NP_080794.2","30974833","Rhododendrin is cytoprotective against 6-hydroxydopamine (6-OHDA)-induced cell death, which is largely dependent on ERbeta activity and RNF146 expression. Publication Status: Online-Only"
> "Q9CZW6-1","RefSeq","NP_080794.2","28581440","These findings indicate that RNF146 is required to coordinate beta-catenin signaling within the osteoblast lineage during embryonic and postnatal bone development"
> "Q9CZW6-1","RefSeq","NP_080794.2","28287403","RANKL represses the transcription of the E3 ubiquitin ligase RNF146 through an NF-kappaB-related inhibitory element in the RNF146 promoter."
> "Q9CZW6-1","RefSeq","NP_080794.2","27521426","A new function of RNF146 and tankyrase in stabilizing the Crumbs complex through downregulation of AMOT proteins at the apical membrane, is reported."
> "Q9CZW6-1","RefSeq","NP_080794.2","24842055","Modulation of PARP-1-mediated oxidative cell injury by ring finger protein 146 (RNF146) in cardiac myocytes Publication Status: Online-Only"
> "Q9CZW6-1","RefSeq","NP_080794.2","23333241","Iduna acts as a potential antioxidant by improving mitochondrial function and inhibiting oxidative stress-induced parthanatos, and these protective effects are dependent on the involvement of ubiquitin-proteasome system."
15713d21164
< "O88898-1","RefSeq","NP_001120731.1","30866939","GSK-3beta was essential for sustaining fetal oocyte survival and folliculogenesis via fine-tuning the cytoplasmic-nuclear translocation of beta-catenin, which in turn modulates timely TAp63 expression during meiotic prophase I in mice. Publication Status: Online-Only"
15714a21166
> "Q3UHJ0-1","RefSeq","NP_808430.2","29774516","Periodic variation in AAK1 expression is closely correlated to the decline in cognition in mouse model of Alzheimer's disease."
15723,15724d21174
< "Q7SIG6-1","RefSeq","NP_001091637.1","28322786","In conclusion, we have identified that ARL15 acts as an insulin-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1/PDPK1/AKT insulin pathway by interacting with its GAP ASAP2 and activating PDPK1. This research may provide new insights into GTPase-mediated insulin signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin sensitizati"
< "Q7SIG6-1","RefSeq","NP_001091637.1","27601625","These findings identify ASAP2 as a new target of Selk-dependent palmitoylation and reveal a new mechanism regulating the efficiency of FcgammaR-mediated phagocytosis."
15737a21188
> "Q99KZ6-1","RefSeq","NP_653102.1","23617998","ZASC1 is important for myeloid cell differentiation in the bone marrow compartment and that this cellular factor is required for efficient Moloney murine leukemia virus replication in this tissue. Publication Status: Online-Only"
15739a21191,21200
> "Q9D777-1","RefSeq","NP_076006.2","28267197","This study identifies APRIL as a new target involved in B-cell activation, in the maintenance of plasma cell survival and subsequent increased autoantibody production that sustains lupus development in mice"
> "Q9D777-1","RefSeq","NP_076006.2","12354377","Review. Dendritic cell-derived TNF-family ligand APRIL enhances plasmablast survival and differentiation to plasma cells. Review article"
> "P33175-1","RefSeq","NP_032473.2","30068641","The authors concluded that kinesin-1 proteins KIF5A, -5B, and -5C are important in the anterograde transport of the majority of herpes simplex virus enveloped virions in neuronal axons and kinesin-3 proteins are less important. Publication Status: Online-Only"
> "P33175-1","RefSeq","NP_032473.2","28910443","Klf5 contributes to adult mouse corneal epithelial homeostasis by promoting (1) permeability barrier function through upregulation of Tjp1, Gkn1, Dsg1a, Lama3, and Lamb1, and (2) basal cell proliferation through upregulation of cyclin-D1 and suppression of phospho(Ser-10) p27/Kip1"
> "P33175-1","RefSeq","NP_032473.2","28676645","These results support our hypothesis that KIF5A is responsible for collagen transportation and secretion from HPMCs. Publication Status: Online-Only"
> "P33175-1","RefSeq","NP_032473.2","27505885","Results from the present study reveal a new system mediated by kinesin-1 sorting in axons that differentially controls stability of arbor terminals."
> "P98063-1","RefSeq","NP_033885.2","30446646","Biochemical studies identify a Bmp-mTORC1-Hif1a signaling cascade resulting in upregulation of Glut1 in chondrocytes that is essential for murine skeletal development. Publication Status: Online-Only"
> "P98063-1","RefSeq","NP_033885.2","28923241","Study show that integrin alpha9beta1 antagonizes both alpha3beta1-dependent mTLD/BMP-1 expression and basement membrane (BM) assembly/maturation. These findings indicate a complex interplay between these two integrins whereby alpha3beta1 promotes, and coordinately, alpha9beta1 inhibits mTLD/BMP-1 production and laminin-gamma2 processing to effect timely BM assembly and maturation during wound healing."
> "P98063-1","RefSeq","NP_033885.2","28928204","Bone morphogenetic protein and retinoic acid synergistically specify female germ-cell fate in mice."
> "Q9CX53-1","RefSeq","NP_080329.1","17023415","Gemin8 has an essential role in the proper structural organization of the SMN complex and the involvement of the heteromeric subunit containing Gemin6, Gemin7, Gemin8, and Unrip in the recruitment of Sm proteins to the snRNP assembly pathway"
15744a21206,21207
> "Q63870-1","RefSeq","NP_031764.2","29305555","Specifically binds and sequesters the innate immune activator cochlin in the lumen of lymphoid conduits"
> "Q63870-1","RefSeq","NP_031764.2","27989960","Biophysical characterization of a pathogenic type VII collagen mutant is presented. The pathogenic mutant lowers thermal stability of the type VII collagen domain. Due to unfolding, protease cleavage sites in the domain become accessible."
15747a21211,21212
> "Q6PAR5-1","RefSeq","NP_079985.2","18434594","The TC10/GAPEX-5/Rab5 axis mediates insulin-stimulated production of PI(3)P, which regulates trafficking of Glut4 vesicles"
> "Q6PAR5-1","RefSeq","NP_079985.2","17189207","Insulin recruits the CIP4/Gapex-5 complex to the plasma membrane, thus reducing Rab31 activity and permitting Glut4 vesicles to translocate to the cell surface, where Glut4 docks and fuses to transport glucose into the cell."
15757a21223,21226
> "Q8K352-1","RefSeq","NP_083049.1","26306874","This study describes SLy1 as an immunoregulatory protein, which is involved in the generation of adaptive immune responses during L. monocytogenes infection, and provides a model of how SLy1 regulates T-cell proliferation."
> "Q8K352-1","RefSeq","NP_083049.1","19604361","Anti-apoptotic protein required for T cell differentiation to the CD4+CD8+ stage, likely to be involved in mTOR complex activation Publication Status: Online-Only"
> "Q8K352-1","RefSeq","NP_083049.1","18950867","Expression of the Notch signaling mediator RBP-J and the Notch target genes Hes-1 and Hes-5 was markedly reduced in MZ but not FO B cells of Sly1(d/d) mice."
> "Q8K352-1","RefSeq","NP_083049.1","16227612","Sly1 is an essential molecular component for the full activation of adaptive immunity"
15766a21236,21242
> "Q9JKV2-1","RefSeq","NP_064371.2","29635032","These results suggest that Ick is expressed in proliferating regions in the adult mouse brain, testis, and intestine."
> "Q9JKV2-1","RefSeq","NP_064371.2","29098359","Loss of ICK function markedly reduced mineralization in the spinal column, ribs, and long bones"
> "Q9JKV2-1","RefSeq","NP_064371.2","28380258","Data indicate an essential role for intestinal cell kinase (ICK) in lung development and advances the mechanistic understanding of endocrine-cerebro-osteodysplasia (ECO) syndrome."
> "Q9JKV2-1","RefSeq","NP_064371.2","28115485","The results of this study found that loss of Ick leads to abnormal localization of the IFT component in kinocilia, PCP defects in HCs, and hearing dysfunction."
> "Q9JKV2-1","RefSeq","NP_064371.2","24244486","The expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases. Publication Status: Online-Only"
> "Q9JKV2-1","RefSeq","NP_064371.2","20459822","ICK and FBX9 are divergently transcribed from a bidirectional promoter that is GC-rich and contains a CpG island. Publication Status: Online-Only"
> "F8VPZ5-1","RefSeq","NP_001074690.1","25762674","This study demonistrated that Cockayne syndrome group b deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice."
15772a21249,21250
> "Q3TMX7-1","RefSeq","NP_705787.1","29800099","Our study provides the first comprehensive comparisons between QSOX1 and QSOX2 in the mouse epididymis, revealing their distinct epididymal distribution, cellular localization, mechanisms of secretion and sperm membrane association"
> "P07141-1","RefSeq","NP_031804.3","30767584","In ovarian follicles, following the luteinizing hormone surge, levels of MCSF and MCSF receptor decrease"
15773a21252,21253
> "Q9JJN1-1","RefSeq","NP_064397.1","30772303","FGF21 had no direct effect on the activation of primordial follicles, but instead required an adipokine adiponectin. Moreover, AdipoRon, an oral adiponectin receptor agonist, prevented the over-activation effect of excessive protein intake on primordial follicle activation."
> "Q9JJN1-1","RefSeq","NP_064397.1","30389922","SIRT1 promotes FGF21 signalling in oxytocin neurons and stimulates Oxt transcription through NRF2. Publication Status: Online-Only"
15777a21258,21260
> "Q91Z67-1","RefSeq","NP_001074480.2","29242313","SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration."
> "Q91Z67-1","RefSeq","NP_001074480.2","27966608","Results show that the effects of Srgap2 expression modulation in the murine OS cell lines support the hypothesis that SRGAP2 may have a role as a suppressor of metastases in osteosarcoma. Publication Status: Online-Only"
> "Q91Z67-1","RefSeq","NP_001074480.2","23505444","The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells."
15793a21277,21280
> "Q8C0N2-1","RefSeq","NP_766303.1","30523059","Glycerolipid synthesis is induced during macrophage activation. GPAT4 protein level and GPAT3/GPAT4 enzymatic activity increase during this process, and these two isoforms were required for the accumulation of cell TAG and PL. Publication Status: Online-Only"
> "Q8C0N2-1","RefSeq","NP_766303.1","27806294","These data identify SEIPIN as an evolutionarily conserved regulator of microsomal GPAT."
> "Q8C0N2-1","RefSeq","NP_766303.1","26644473","These studies identify GPAT3 as a novel enzyme involved in intestinal lipid metabolism."
> "Q8C0N2-1","RefSeq","NP_766303.1","24714397","GPAT3 is the primary GPAT in white adipose tissue and has an important role of the enzyme in regulating energy, glucose, and lipid homeostasis."
15795a21283,21296
> "Q9JLH8-1","RefSeq","NP_057921.1","26586224","RNAi depletion of Tmod1 from either wild-type or Tmod4(-/-) muscle fibers leads to thin filament elongation by approximately 15%."
> "Q9JLH8-1","RefSeq","NP_057921.1","24430868","Calpain-mediated proteolysis of tropomodulin isoforms TMOD1 and TMOD4 leads to thin filament elongation in dystrophic skeletal muscle."
> "Q9JLH8-1","RefSeq","NP_057921.1","20368620","Tmod4 localizes to thin filament pointed ends in Tmod1-null embryonic muscle"
> "Q6PER3-1","RefSeq","NP_579928.1","29247211","The authors propose that EB3 is involved in regulation of dendritic spines morphology, in part due to its association with STIM2, and that modulation of EB3 expression is a potential way to overcome synaptic loss during Alzheimer's disease. Publication Status: Online-Only"
> "Q6PER3-1","RefSeq","NP_579928.1","26119739","EB3 binds to IP3 receptors, promotes IP3R clustering and Ca2+ signals in endothelial cells."
> "Q6PER3-1","RefSeq","NP_579928.1","25761518","We describe here a novel function for tau as a direct regulator of End binding (EB) proteins in differentiating neuronal cells"
> "Q6PER3-1","RefSeq","NP_579928.1","18283108","Two +TIPs, CLIP-170 and end-binding protein 3 (EB3), turn over rapidly on MT ends. Diffusion of CLIP-170 and EB3 appears to be rate limiting for their binding to MT plus ends."
> "Q6PER3-1","RefSeq","NP_579928.1","17310996","DDA3 is a novel microtubule-associated protein that binds to EB3, and results implicate DDA3 and EB3 in the beta-catenin-mediated growth signaling."
> "Q8BU91-1","RefSeq","NP_796217.2","23149824","The chloride channel/transporter Slc26a9 regulates the systemic arterial pressure and renal chloride excretion."
> "Q8BU91-1","RefSeq","NP_796217.2","22945630","SLC26A9 is activated in airway inflammation. Slc26a9-deficient mice exhibited IL-13-induced airway mucus obstruction. SLC26A9-mediated Cl- secretion is essential for preventing airway obstruction in allergic airway disease."
> "Q8BU91-1","RefSeq","NP_796217.2","20413716","Cellular HCO(3)(-) secretion, likely through SLC26A9, is the dominant mechanism whereby gastric mucosal surface pH transiently increases in response to photodamage."
> "Q8BU91-1","RefSeq","NP_796217.2","19365592","Slc26a9 has three discrete physiological modes: nCl(-)-HCO(3)(-) exchanger, Cl(-) channel, and Na(+)-anion cotransporter."
> "Q8BU91-1","RefSeq","NP_796217.2","19004773","Slc26a9 plays an essential role in gastric acid secretion via effects on the viability of tubulovesicles/secretory canaliculi and by regulating chloride secretion in parietal cells."
> "Q8BU91-1","RefSeq","NP_796217.2","17120765","Slc26a9 functions as an electrogenic nCl-/HCO3- exchanger, suggesting a role in pulmonary and gastric HCO3- secretion and/or CO2 transport."
15828a21330,21332
> "Q9D1T0-1","RefSeq","NP_851419.1","28193690","Myelin loss and subsequent axon degeneration contributes to a variety of neurological diseases, such as multiple sclerosis (MS)."
> "Q9D1T0-1","RefSeq","NP_851419.1","25681574","These data provide morphometric and functional evidence of enhancement of remyelination associated with antagonism of LINGO-1"
> "Q9D1T0-1","RefSeq","NP_851419.1","17726113","Inhibitory agents of LINGO-1 activity can protect dopaminergic neurons against degeneration"
15830a21335,21336
> "Q8C8M1-1","RefSeq","NP_062617.2","30070635","Our data suggest that Fam60a is required for proper embryogenesis, at least in part as a result of its regulation of DNA methylation at specific gene promoters. Publication Status: Online-Only"
> "Q8C8M1-1","RefSeq","NP_062617.2","28554894","Taken together, Fam60a is an essential core subunit of a variant Sin3a-Hdac complex in embryonic stem cells that is required to promote rapid proliferation and prevent unscheduled differentiation."
15842a21349,21351
> "Q9WVL0-1","RefSeq","NP_034493.1","16376852","Glutathione S-transferase zeta/maleylacetoacetate isomerase is induced by C/EBPalpha and dependent on PPAR gamma"
> "Q9WVL0-1","RefSeq","NP_034493.1","16278372","GSTZ1-1 deficiency may alter the metabolism of some drugs and xenobiotics."
> "Q9WVL0-1","RefSeq","NP_034493.1","12052898","Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice reveal a glutathione-dependent nonenzymatic bypass in tyrosine catabolism"
15844,15845c21353,21355
< "O35892-1","RefSeq","NP_001300641.1","31180531","Findings demonstrated that spheroids from pancreatic cancer cells caused circular defects in lymphatic endothelial monolayers. These CCIDs in pancreatic cancer were partly regulated by S100P."
< "O35892-1","RefSeq","NP_001300641.1","11471051","Identification and analysis of the genes Sp100, Csprs, and Ifi75 in two members of the genus Mus, M. musculus and M. caroli"
---
> "E9Q3L2-1","RefSeq","NP_001001983.2","29386109","Mutation of Pi4ka found to promote myeloid and erythroid dysfunction. Subsequent validation experiments showed that targeted inactivation of the Pi4ka catalytic domain or reduction in mRNA expression inhibited myeloid and erythroid cell differentiation in vitro and promoted anemia in vivo"
> "E9Q3L2-1","RefSeq","NP_001001983.2","19581584","Loss of phosphatidylinositol 4-kinase 2alpha activity causes late onset degeneration of spinal cord axons."
> "Q02257-1","RefSeq","NP_034723.1","29802338","Essential to the maintenance of the structure of the corneal epithelium and its wound healing"
15850,15851c21360,21372
< "Q9D385-1","RefSeq","NP_077153.1","29718757","ARL2BP is necessary for photoreceptor ciliary doublet formation and axoneme elongation."
< "Q9D385-1","RefSeq","NP_077153.1","18234692","BART is essential for the transcriptional activity and nuclear retention of STAT3"
---
> "O55102-1","RefSeq","NP_056555.2","28900165","Data show that the mitochondrial enriched GCN5-like 1 protein (GCN5L1) controls hepatic glucose production by regulating FoxO1 protein levels. Publication Status: Online-Only"
> "O55102-1","RefSeq","NP_056555.2","28526709","Acetylation of cardiac mitochondrial fatty acid oxidation enzymes by GCN5L1 significantly upregulates their activity in diet-induced obese mice."
> "O55102-1","RefSeq","NP_056555.2","28319092","TDH, responsible for mitochondrial production of acetyl-CoA in mouse embryonic stem cells, and the acetyltransferase GCN5L1 cooperate to acetylate Lys501 in KBP, allowing its recognition by and degradation via Fbxo15, an F-box protein transcriptionally controlled by the pluripotency core factors and repressed following differentiation."
> "O55102-1","RefSeq","NP_056555.2","16760431","These results indicate that the BLOC-1 and AP-3 protein complexes affect the targeting of SNARE and non-SNARE AP-3 cargoes and suggest a function of the BLOC-1 complex in membrane protein sorting."
> "O55102-1","RefSeq","NP_056555.2","15265785","Defects in all the 5 known components of BLOC-1, including RP, cause severe Hermansky Pudlak syndrome in mice, suggesting that the subunits are nonredundant and that BLOC-1 plays a key role in organelle biogenesis."
> "O55102-1","RefSeq","NP_056555.2","15102850","Mutations in the human genes encoding Snapin and the BLOS proteins could underlie novel forms of Hermansky-Pudlak syndrome as seen in mouse models"
> "Q9ESS0-1","RefSeq","NP_071302.2","29047406","MKP-5 negatively regulates apoptotic signaling in skeletal muscle. During regeneration, MKP-5 downregulation contributes to myofiber survival. Publication Status: Online-Only"
> "Q9ESS0-1","RefSeq","NP_071302.2","28096466","MKP-5-mediated regulation of JNK negatively regulates phosphorylation of GRAB, which subsequently controls secretion of IL-6"
> "Q9ESS0-1","RefSeq","NP_071302.2","15306813","MKP5 has a principal function in both innate and adaptive immune responses, and represents a novel target for therapeutic intervention of immune diseases"
> "Q8K3G5-1","RefSeq","NP_598706.1","28412365","Finally, downregulation of hvrk3 using siRNA reduced the amplitude and lengthened the period of the cellular bioluminescence rhythm. Taken together, these data suggest that VRK3 plays a role in setting the amplitude and period length of circadian rhythms in mammalian cells."
> "Q8K3G5-1","RefSeq","NP_598706.1","27346674","Stress-induced nuclear translocation of CDK5 suppresses neuronal death by downregulating ERK activation via VRK3 phosphorylation Publication Status: Online-Only"
> "Q8K3G5-1","RefSeq","NP_598706.1","25899223","These data suggest that VRK3-mediated phosphorylation of BAF may facilitate DNA replication or gene expression by facilitating the dissociation of nuclear envelope proteins and chromatin during interphase."
> "Q8K3G5-1","RefSeq","NP_598706.1","12782311","VRK genes play a role during embryonic development of hematopoiesis"
15855a21377,21380
> "Q8R1H0-1","RefSeq","NP_783199.1","12975471","Data show that Hop can inhibit serum response factor-dependent transcriptional activation by recruiting histone deacetylase (HDAC) activity and can form a complex that includes HDAC2"
> "Q8R1H0-1","RefSeq","NP_783199.1","12617835","Expressed in embryonic myocardium and other mesoderm, but not in endocardium or great vessels."
> "Q8R1H0-1","RefSeq","NP_783199.1","12297046","HOP is highly expressed in the developing heart, dependent on the cardiac-restricted homeodomain protein Nkx2.5. Mice homozygous for a HOP null allele segregate into two phenotypic classes characterized by an excess or deficiency of cardiac myocytes."
> "Q8R1H0-1","RefSeq","NP_783199.1","12297045","Inactivation of Hop in mice by homologous recombination results in a partially penetrant embryonic lethal phenotype with severe developmental cardiac defects involving the myocardium."
15858a21384
> "O08969-1","RefSeq","NP_033460.1","15327781","Phlda2 gene is imprinted, with preferential expression from the maternal allele in placenta. It acts as a rheostat for placental growth, with overgrowth after gene deletion and growth retardation after loss of imprinting."
15890a21417,21420
> "Q08874-1","RefSeq","NP_032627.1","30471646","Cardiac mast cells are dependent on Mitf expression, with loss-of-function mutation in the Mitf gene leading to near-complete lack of cardiac mast cells. Loss of a single Mitf allele is sufficient for relative mast cell deficiency."
> "Q08874-1","RefSeq","NP_032627.1","17438132","Data show that there is physiological switching of Mitf isoforms and that the promoter context and the cell context have a combined influence on gene expression programs."
> "Q08874-1","RefSeq","NP_032627.1","17182576","This work defines the transcriptome regulated by Mitf in mast cells and supports its role as master regulator of mast cell differentiation."
> "Q9DCX2-1","RefSeq","NP_082138.1","30124467","Multimodality resistance arises through a core metabolic reprogramming pathway instigated by epigenetic loss of the ATP synthase subunit ATP5H, which leads to ROS accumulation and HIF-1alpha stabilization under normoxia"
15893a21424,21428
> "P47759-1","RefSeq","NP_032767.1","30680309","NSG2 is found in discrete punctae restricted to the somatodendritic arbors of developing mouse and human neurons, and a significant proportion of NSG2 punctae colocalize with postsynaptic HOMER1 and surface-expressed AMPA-type glutamate receptors (AMPARs) at excitatory synapses. Publication Status: Online-Only"
> "P47759-1","RefSeq","NP_032767.1","28299779","We show that NEEP21/Nsg1 and P19/Nsg2 are present in both overlapping and distinct cell populations in the hippocampus, neocortex, and cerebellum during development."
> "P47759-1","RefSeq","NP_032767.1","25872778","Fbxl10 is a bona fide oncogene, whose deregulated expression contributes to the development of leukemia involving metabolic proliferative advantage and Nsg2-mediated impaired differentiation."
> "Q61907-1","RefSeq","NP_032845.2","28291718","Results show that hepatic PEMT protein levels and activity are post-translationally repressed in homocystinuria and correlates with decreased phosphatidylcholine."
> "Q61907-1","RefSeq","NP_032845.2","28159867","Fenofibrate partially reversed hepatic steatosis and fibrosis in Pemt(-/-) mice when treatment was initiated after nonalcoholic fatty liver disease (NAFLD) had already been established. Increasing hepatic fatty acid oxidation can compensate for the lower VLDL-triacylglycerol secretion rate and prevent/reverse fatty liver disease in mice lacking PEMT."
15895,15898d21429
< "P15806-1","RefSeq","NP_001157621.1","30659202","E47 and GR co-occupy metabolic promoters and enhancers. E47 is needed for the efficient recruitment of GR and coregulators such as Mediator to chromatin. Publication Status: Online-Only"
< "P15806-1","RefSeq","NP_001157621.1","29966657","Upregulation of lncRNA CASC15 induced by VDR transcription factor facilitates cardiac hypertrophy via miR-432-5p/TLR4 axis."
< "P15806-1","RefSeq","NP_001157621.1","29703840","Data show that inhibitor of DNA binding 2 protein (ID2) limited chromatin accessibility at transcription factor E2A protein binding sites near naive T lymphocyte-associated genes."
< "P15806-1","RefSeq","NP_001157621.1","29440362","Continued Id2 regulation of E-protein activity is required to maintain the KLRG1(hi) CD8(+) T cell population after lymphocytic choriomeningitis virus infection."
15923a21455,21460
> "Q99ML1-1","RefSeq","NP_573497.1","30971184","The study suggests that targeting MIAT may protect against cardiomyocytes against hypoxia-reperfusion injury or myocardial ischemia-reperfusion injury via inhibition of cell apoptosis, mediated by NF-kappaB and PUMA signaling pathway."
> "Q99ML1-1","RefSeq","NP_573497.1","30394308","Using gain- and loss-of-function approaches, we identified a unique role of miR-143/PUMA in mediating microglial activation via regulation of NLRP3 inflammasome activation."
> "Q99ML1-1","RefSeq","NP_573497.1","30503207","TFEB functions cell-autonomously through PUMA induction and Bax-Bak activation to promote programmed cell death of a subset of premyelinating oligodendrocytes, allowing selective elimination of oligodendrocytes in normally unmyelinated brain regions."
> "Q99ML1-1","RefSeq","NP_573497.1","15192153","PUMA shRNAs were unable to cooperate with oncogenic ras in transformation"
> "Q99ML1-1","RefSeq","NP_573497.1","14500851","Puma and Noxa are critical mediators of the apoptotic responses induced by p53 and other agents"
> "Q99ML1-1","RefSeq","NP_573497.1","14585359","Puma as a principal mediator of cell death in response to diverse apoptotic signals"
15929,15930d21465
< "P47931-1","RefSeq","NP_001288302.1","30995923","This study identified Sp1 as the critical transcription factor regulating activation of the FST promoter in cav-1 KO MC through binding to a region within 123 bp of the transcription start site. Publication Status: Online-Only"
< "P47931-1","RefSeq","NP_001288302.1","20032047","The FST288-only isoform is sufficient for development. Loss of FST303 and FST315 isoforms results in fertility defects that resemble activin hyperactivity and premature ovarian failure."
15934a21470,21473
> "Q71RI9-1","RefSeq","NP_776124.1","20482848","KAT III inhibited by equimolar methionine and half-life is 3.9 minutes at 65 degree C. Publication Status: Online-Only"
> "Q71RI9-1","RefSeq","NP_776124.1","19029248","The biochemical and structural properties of mouse KAT III (mKAT III) were determined. Erratum:[Mol Cell Biol. 2018 Apr 30;38(10 ):. PMID: 29712768]"
> "Q80UK0-1","RefSeq","NP_780674.1","23696638","Data indicate that Sestd1 cooperates with Dact1 in Vangl2 regulation and in the planar cell polarity (PCP) pathway during mammalian embryonic development."
> "Q80UK0-1","RefSeq","NP_780674.1","16943433","These results suggest that Solo/Trio8 acts as an early-endosome-specific upstream activator of Rho family GTPases for neurite elongation of developing Purkinje neurons.[Trio8]"
15939a21479,21481
> "P84244-1","RefSeq","NP_032237.1","29358330","Data (including data from studies using transgenic mice) suggest that H3f3a and H3f3b are required for (1) paternal chromatin remodeling, (2) development of preimplantation embryos, and (3) activation of paternal genome during embryogenesis."
> "P84244-1","RefSeq","NP_032237.1","27791098","Data show that knockdown of either H3f3a or H3f3b in isolation in brain is not sufficient to block stimulus-dependent H3.3 protein turnover."
> "P84244-1","RefSeq","NP_032237.1","26304540","In H3f3a and H3f3b null mouse embryonic stem cells, H3.3 deficiency results in reduced levels of H3K9me3 level, H4K20me3 and ATRX at the telomeres, accompanied with an increase in telomeric transcription."
15940a21483,21485
> "Q9Z351-1","RefSeq","NP_034741.2","30382937","Decreases in interneuron KCNQ2/3 activity remodels excitatory networks, providing a new function for these channels. Publication Status: Online-Only"
> "Q9Z351-1","RefSeq","NP_034741.2","28575529","The data of this study showed that, in Kcnq2 mutant slices, burst activity was modulated by GABAA receptor blockade."
> "Q9Z351-1","RefSeq","NP_034741.2","28100740","Kcnq2 ablation leads to increased neuronal excitability of neocortex layer 2/3 pyramidal neurons."
15952c21497,21501
< "Q8C5H8-1","RefSeq","NP_001078879.1","23616928","MNADK is localized to mitochondria in Hep G2 cells, and a recombinant MNADK showed NAD kinase activity. MNADK is abundant in mitochondrion-rich tissues, such as liver. MNADK expression was suppressed in human liver tumors. Identification of MNADK immediately suggests a model in which NADK and MNADK are responsible for de novo synthesis of NADP(+) in cytosol and mitochondria, respectively. Publication Status: Online-Only"
---
> "Q8BTF7-1","RefSeq","NP_795927.2","26608917","The data firmly demonstrate Lig4(R278H) activity renders nonhomologous end-joining (NHEJ) DNA repair to be more error-prone, and predict increased error-prone NHEJ and A-EJ suppression as the cause of defective B lymphopoiesis in Lig4 patients."
> "Q9JI57-1","RefSeq","NP_065064.2","29320702","GTF2IRD1 represses the transcription of transforming growth factor beta-dependent pro-fibrosis genes by recruiting PRDM16 and EHMT1 onto their promoter/enhancer regions."
> "Q9JI57-1","RefSeq","NP_065064.2","27295951","The absence of GTF2IRD1 is associated with increased expression of genes involved in cellular proliferation, including growth factors consistent with the observed phenotype of extreme thickening of the epidermis. Publication Status: Online-Only"
> "Q9JI57-1","RefSeq","NP_065064.2","27239038","The mis-regulation of genes downstream of GTF2IRD1, including TbetaR2 and BMPR1b, also individually promoted mammary cancer development, and silencing of TbetaR2 suppressed GTF2IRD1-driven tumor promotion."
> "Q80Y24-1","RefSeq","NP_001127933.1","17376975","Putative planar cell polarity protein prickle-like 2 is distributed in crescents on the medial sides of vestibular epithelial cells before the morphological polarization of hair cells."
15953a21503,21504
> "Q8K1E0-1","RefSeq","NP_062803.4","28000760","Stx5 is an autophagy target that is inefficiently membrane-targeted by alternative pathways; mice without WRB have different biogenesis requirements for tail anchored proteins Publication Status: Online-Only"
> "Q8K1E0-1","RefSeq","NP_062803.4","18836075","Pkd2 in the ER plays a role in cellular Ca(2+) homeostasis and Stx5 functions to inactivate Pkd2 and prevent leaking of Ca(2+) from ER stores"
15956a21508,21509
> "A2APB8-1","RefSeq","NP_082385.3","28205572","Depleting TPX2 decreases microtubule formation frequency specifically at the tip and the base of the neurite, and these correlate precisely with the regions where active GTP-bound Ran proteins are enriched. Publication Status: Online-Only"
> "A2APB8-1","RefSeq","NP_082385.3","27753540","Bcl2l10, Tpx2, and Aurka co-localized on the meiotic spindles, and Bcl2l10 was present in the same complex with Tpx2."
15967,15972d21519
< "Q99NF2-1","RefSeq","NP_001034475.1","26977770","BDNF application can rescue the morphological deficits in hippocampal pyramidal neurons devoid of Jacob. Taken together, the data suggest that the absence of Jacob in early development interrupts a positive feedback loop between BDNF signaling Publication Status: Online-Only"
< "Q99NF2-1","RefSeq","NP_001034475.1","25731822","NELF knockout is associated with impaired pubertal development and subfertility."
< "Q99NF2-1","RefSeq","NP_001034475.1","24656816","Findings strongly indicate that NELF is part of the PPARalpha-mediated transcription regulatory network that maintains metabolic homeostasis in cardiomyocytes."
< "Q99NF2-1","RefSeq","NP_001034475.1","24316376","The nuclear and non-nuclear NELF variant transcripts and proteins were identified, explaining variable NELF cellular localization."
< "Q99NF2-1","RefSeq","NP_001034475.1","24317321","Jacob operates as a mobile hub that docks NMDA receptor-derived signalosomes to nuclear target sites."
< "Q99NF2-1","RefSeq","NP_001034475.1","19608740","Calpain-mediated clipping of the myristoylated N terminus of Jacob is required for its nuclear translocation after N-methyl-d-aspartate receptor activation"
15990a21538,21542
> "Q60714-1","RefSeq","NP_036107.1","29272817","This study shows that FATP1 regulates the production of inflammatory cytokines through ceramide and the c-Jun N-terminal kinase signaling pathway"
> "Q60714-1","RefSeq","NP_036107.1","29035781","Macrophage Fatp1 limits atherogenesis in LDL receptor knockout mice."
> "Q8BMB3-1","RefSeq","NP_075803.2","25624349","DNA damage induces an increase in ARIH1 protein levels and association of ARIH1 with Eif4e2. In turn, this causes Eif4e2 recruitment to the mRNA cap, where it is known to compete with eIF4E."
> "Q8BMB3-1","RefSeq","NP_075803.2","19365557","Data show that Prep1 and 4EHP co-localize in the cytosol of growing mouse oocytes, and that Prep1 binds the Hoxb4 3'UTR to inhibit its translation.[4EHP]"
> "Q09014-1","RefSeq","NP_035006.3","30076526","AT2R, via PP2A-mediated inhibition of PKC, prevents the NOX activation, reactive oxygen species generation, and subsequent pro-inflammatory activation of microglia."
15993a21546,21551
> "P28649-1","RefSeq","NP_031836.1","29880879","Data provide evidence of a local increase of aromatase expression by reelin. Regarding reproduction, this crosstalk may contribute to follicular stability and counteract luteinization in ovaries. Publication Status: Online-Only"
> "P28649-1","RefSeq","NP_031836.1","29459742","Our findings show that aromatase inhibition in females is associated with elevated intraocular pressure (IOP) and retinal ganglion cells (RGCs) counts. Publication Status: Online-Only"
> "Q8CEE6-1","RefSeq","NP_543126.2","30038292","PASK regulated some of the genes and proteins responsible for glucose sensing, such as glucokinase. Publication Status: Online-Only"
> "Q8CEE6-1","RefSeq","NP_543126.2","27338626","The findings demonstrate cell-autonomous roles for PASK in the control of pancreatic endocrine hormone secretion. Differences between the glycaemic phenotype of global vs cell type-specific null mice suggest important roles for tissue interactions in the control of glycaemia by PASK."
> "Q8CEE6-1","RefSeq","NP_543126.2","17192472","Paskin gene expression is not induced by glucose in pancreatic beta-cells and glucose-stimulated insulin production is independent of PASKIN."
> "Q8CEE6-1","RefSeq","NP_543126.2","12972598","Targeted disruption of the PAS domain serine/threonine kinase was studied."
15996,15999c21554,21558
< "Q0QWG9-1","RefSeq","NP_001152793.1","18509461","Findings are compatible with the idea that LTD induction at PF-PC synapses is a crucial rate-limiting step in optokinetic resonse gain-increase adaptation, a simple form of motor learning Publication Status: Online-Only"
< "Q0QWG9-1","RefSeq","NP_001152793.1","16168524","Results show that the Delphilin protein exhibits diversity at its N-terminus by variable usage of the first several exons."
< "Q0QWG9-1","RefSeq","NP_001152793.1","12628171","Absence of GRID2 receptors in heteroallelic mutants induces an early and massive Purkinje cell death that is correlated with early signs of autophagy and is independent of depolarization."
< "Q0QWG9-1","RefSeq","NP_001152793.1","12372286","A direct link exists between GluR2delta receptor and stimulation of the autophagic pathway in dying Purkinje cells of lurcher mice."
---
> "Q8BQY8-1","RefSeq","NP_032342.1","25915840","Whereas Hus1(neo/neo) and Atm(-/-) single mutant mice survived low-dose MMC similar to wild-type controls, Hus1(neo/neo)Atm(-/-) double mutants showed striking MMC hypersensitivity."
> "Q8BQY8-1","RefSeq","NP_032342.1","23468651","HUS1 acts as a component of the canonical 9-1-1 complex during meiotic prophase I to promote DSB repair and further propose that RAD1 and TOPBP1 respond to unsynapsed chromatin through an alternative mechanism that does not require RAD9 or HUS1."
> "Q8BQY8-1","RefSeq","NP_032342.1","22575700","Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1"
> "Q8BQY8-1","RefSeq","NP_032342.1","19918068","Requirement for Hus1 in the survival and proliferation of mammary epithelium"
> "Q8BQY8-1","RefSeq","NP_032342.1","17220276","Identify differential effects of altered Hus1 gene dosage on genome maintenance during in vitro culture, genotoxic stress responses, embryonic development, and adult homeostasis"
16010a21570,21573
> "O88721-1","RefSeq","NP_062277.1","28630289","Type-2 vasopressin receptor in polycystic kidney disease is targeted by green mamba peptide"
> "O88721-1","RefSeq","NP_062277.1","28215940","Conditional inactivation of Elf5 in the developing collecting ducts results in a small but significant reduction in the expression levels of Aqp2 and Avpr2 genes."
> "O88721-1","RefSeq","NP_062277.1","27649563","Data show that upon heteromer formation with secretin receptor (SCTR), R137H, a nephrogenic diabetes insipidus (NDI)-causing vasopressin receptor 2 (AVPR2) mutant that is defective in trafficking to cell surface, can functionally be rescued. Publication Status: Online-Only"
> "O88721-1","RefSeq","NP_062277.1","26903624","Data show that cryptochrome Cry1 and Cry2 expression must be circadian and appropriately phased to support rhythms, and arginine vasopressin (AVP) receptor signaling is required to impose circuit-level circadian function."
16014a21578,21580
> "Q8CHB8-1","RefSeq","NP_001334324.1","28173158","Mouse models carrying truncating mutations in TTLL5 gene display reduced fertility in male animals."
> "Q8CHB8-1","RefSeq","NP_001334324.1","27162334","Study uncovers the pathogenic mechanism whereby absence of RPGR(ORF15) glutamylation leads to retinal pathology in patients with TTLL5 gene mutations and connects these two genes into a common disease pathway."
> "Q8CHB8-1","RefSeq","NP_001334324.1","23558686","STAMP appears to participate in a unique, tissue-selective TTLL-mediated pathway for alpha-tubulin polyglutamylation that is required for sperm maturation and motility and may be relevant for male fertility."
16020a21587,21588
> "Q99P31-1","RefSeq","NP_077134.1","24899640","Male HSPBP1knockout mice are sterile because of impaired meiosis and massive apoptosis of spermatocytes."
> "Q99P31-1","RefSeq","NP_077134.1","15665051","Provides a critical cardioprotective effect in the setting of ischemia-reperfusion injury due in part to increased apoptosis in cardiac cells."
16021a21590
> "Q69ZX8-1","RefSeq","NP_941051.2","17194709","ABLIM-2 and -3 associate with STARS and directly bind F-actin"
16028,16033d21596
< "Q80W99-1","RefSeq","NP_001239416.1","29371110","Data suggest that Catsper1, Catsper2, Catsper3, and Catsper4 form protein multimer with hypothetical activities of flippase and disulfide isomerase."
< "Q80W99-1","RefSeq","NP_001239416.1","20586097","Hydrogen peroxide induced upregulation of catsper3 in brain."
< "Q80W99-1","RefSeq","NP_001239416.1","18607386","Data show that spinal cord injury doesn't significantly change the expression of CatSpers 3."
< "Q80W99-1","RefSeq","NP_001239416.1","17344468","Catsper3 and Catsper4 knockout male mice are completely infertile due to a quick loss of motility and a lack of hyperactivated motility under capacitating conditions."
< "Q80W99-1","RefSeq","NP_001239416.1","16107607","CATSPER3 is a cation-channel protein and has role in acrosome reaction and male fertility"
< "Q80W99-1","RefSeq","NP_001239416.1","12932298","Catsper3 has a single channel-forming domain, a pore-loop with the consensus sequence TxDxW, & a coiled-coil protein-protein interaction domain in the C-terminal tail. CatSpers 1,2,3 & 4 may interact directly or indirectly to form a functional tetramer. Publication Status: Online-Only"
16034a21598,21606
> "Q99LM3-1","RefSeq","NP_077192.1","26048986","Pregnancy promotes switching of skeletal muscle to a glycolytic phenotype through the smoothelin-like protein 1 transcriptional cofactor."
> "Q99LM3-1","RefSeq","NP_077192.1","24905744","Two domains of SMTNL1 bind apo- and calcium-calmodulin independently."
> "Q99LM3-1","RefSeq","NP_077192.1","22424482","Appears that the type-2 CH domain of CHASM is required for tropomyosin binding and presents a novel function for this protein domain"
> "Q99LM3-1","RefSeq","NP_077192.1","21771785","SMTNL1 is a bifunctional co-regulator of PR-B signaling and provides a molecular mechanism whereby PR-B is targeted to alter gene expression patterns within uterine smooth muscle cells to coordinately promote alterations in USM function during pregnancy"
> "Q99LM3-1","RefSeq","NP_077192.1","20634291","Findings define a new conserved pathway in which sexual development and pregnancy mediate smooth and striated muscle adaptations through SMTNL1 and MYPT1."
> "Q99LM3-1","RefSeq","NP_077192.1","20627103","An interaction between CHASM and tropomyosin, is demonstrated."
> "Q99LM3-1","RefSeq","NP_077192.1","18477568","Revealed a close interaction of SMTNL1-homology with the two Ca(2+) binding loop regions of the C-terminal domain of apo-calmodulin"
> "Q99LM3-1","RefSeq","NP_077192.1","18310078","SMTNL1 has roles in cGMP/cAMP-mediated adaptations to exercise through mechanisms involving direct modulation of contractile activity GeneRIF: A knock out mouse for this gene shows an exercise adapted phenotype. The encoded protein has a unique expression profile in striated muscle both in mice and human."
> "Q99LM3-1","RefSeq","NP_077192.1","15327999","CHASM is a novel member of the smoothelin protein family that elicits Ca2+ desensitization in smooth muscle"
16046,16051c21618,21623
< "Q3TJD7-1","RefSeq","NP_001107560.1","27792740","Primary endogenous regulator of platelet-dependent hemostasis Publication Status: Online-Only"
< "Q3TJD7-1","RefSeq","NP_001107560.1","26556890","PDLIM7 is a bona fide skeletal muscle substrate of Nedd4-1."
< "Q3TJD7-1","RefSeq","NP_001107560.1","25677945","Findings describe a positive regulatory effect of LMP-1 on BMP-2 expression and BMP-2-mediated osteogenesis. This effect occurs through activation of ERK1/2 pathway and subsequent upregulation of Runx2 transactivity."
< "Q3TJD7-1","RefSeq","NP_001107560.1","25032549","LMP is an important determinant of weight and length, female bone density, and marrow stromal cell propensity for mineralization."
< "Q3TJD7-1","RefSeq","NP_001107560.1","21060154","The LIM domain protein Enigma directly interacts with MDM2 to form a ternary complex with p53 in embryonic fibroblasts"
< "Q3TJD7-1","RefSeq","NP_001107560.1","20706776","LMP-1 showed spatiotemporal expression patterns during molar development.[LMP-1]"
---
> "Q8CH02-1","RefSeq","NP_081757.1","27206982","Our results strongly support a role for SUGP1 as a novel regulator of cholesterol metabolism and suggest that it contributes to the relationship between rs10401969 and plasma cholesterol"
> "Q8BPY9-1","RefSeq","NP_068691.2","22110678","Fignl1 as a novel actor in mammal's male meiosis dynamics"
> "Q8BPY9-1","RefSeq","NP_068691.2","17352653","FIGNL1, a subfamily member of the AAA family of proteins, might play some regulatory role in osteoblast proliferation and differentiation."
> "Q3URY2-1","RefSeq","NP_001272847.1","26933123","The authors found that GEMC1-deficient mice are growth impaired, develop hydrocephaly with a high penetrance, and are infertile, due to defects in the formation of multiciliated cells in the brain, respiratory tract, and germline."
> "Q3URY2-1","RefSeq","NP_001272847.1","26882546","GemC1 directly transactivates the promoters of MCIDAS and FOXJ1."
> "Q3URY2-1","RefSeq","NP_001272847.1","26395491","Results suggest that Mcidas and GemC1 are key players in the generation of multiciliated ependymal cells of the adult neurogenic niche."
16055a21628
> "P61079-1","RefSeq","NP_079632.1","28469175","Together with Riplet, Ube2D3 promotes covalent conjugation of polyubiquitin chains to RIG-I, while Ube2N preferentially facilitates production of unanchored chains. In the presence of these chains, RIG-I induces MAVS aggregation directly on the mitochondria. Data thus reveal two essential mechanisms underlying the activation of RIG-I and MAVS for triggering innate immune signaling in response to viral infection in cells. Publication Status: Online-Only"
16061a21635,21637
> "Q9Z0M5-1","RefSeq","NP_067435.3","30639734","Data provide evidence that hepatocyte-specific LAL deficiency is sufficient to alter whole-body lipid and energy homeostasis in mice. Hepatic LAL plays a pivotal role by preventing liver damage and maintaining lipid and energy homeostasis, especially during high lipid availability."
> "Q9Z0M5-1","RefSeq","NP_067435.3","29599133","Lysosomal acid lipase has a critical role in promoting both macrophage and whole-body reverse cholesterol transport."
> "Q9Z0M5-1","RefSeq","NP_067435.3","29374543","LAL is critical for shuttling fatty acids derived from circulating lipoproteins to brown adipose tissue during cold exposure."
16064a21641,21643
> "Q61089-1","RefSeq","NP_032082.3","30237242","Fzd3 and Fzd6 play a redundant role in controlling the polarity of developing skin, but through non-identical mechanisms. Publication Status: Online-Only"
> "Q8CEE7-1","RefSeq","NP_780581.1","29656332","The data suggested that the alleviated liver damage induced by CCl4 in Rdh13(-/-) mice was caused by Cyp2e1 enzymes, which promoted reductive CCl4 metabolism by altering the status of thyroxine metabolism. This result further implicated Rdh13 as a potential drug target in preventing chemically induced liver injury."
> "Q8CEE7-1","RefSeq","NP_780581.1","22605914","Rdh13 can protect the retina against acute light-induced retinopathy."
16072a21652,21653
> "Q62448-1","RefSeq","NP_038535.2","9049310","In vitro and in vivo studies in human show that translation starts at a non-AUG (GUG) codon. Suggest the same in mouse based on sequence conservation."
> "Q62448-1","RefSeq","NP_038535.2","9027506","Translation starts at a non-AUG translation initiation codon (GUG)."
16082a21664,21667
> "Q9D7I0-1","RefSeq","NP_080657.1","18677103","Mouse Scotin induces apoptosis and developmental defects when overexpressed in Drosophila."
> "Q9D7I0-1","RefSeq","NP_080657.1","18164684","We conclude that Scotin is a new p63 target gene induced during epithelial differentiation, a complex process that also involves ER stress induction."
> "Q9D7I0-1","RefSeq","NP_080657.1","17889823","ALG-2 binding to Scotin is strictly calcium dependent, indicating a role of this interaction in calcium signaling pathways"
> "Q9D7I0-1","RefSeq","NP_080657.1","12135983","Scotin plays a role in p53-dependent apoptosis"
16086,16097d21670
< "Q6SJQ7-1","RefSeq","NP_001162624.1","30479367","LMIR3-knockout neutrophils displayed significantly augmented cytotoxic activity against P. aeruginosa and C. albicans. LMIR3 expression increased in response to infection in a TLR4/MyD88-dependent manner. Publication Status: Online-Only"
< "Q6SJQ7-1","RefSeq","NP_001162624.1","30127493","Although the serine palmitoyltransferase complex is dispensable for the surface expression of the norovirus receptor (CD300lf), enzyme activity is required for CD300lf to adopt a conformation permissive for viral binding. Addition of extracellular ceramide to serine palmitoyltransferase-deficient cells complements both the conformational changes of CD300lf and the cellular susceptibility to murine norovirus infection."
< "Q6SJQ7-1","RefSeq","NP_001162624.1","30194229","Docking of the cocomplex structures onto a cryo-EM-derived model of MNoV suggests that each virion can make multiple CD300lf engagements, and thus, infection may be driven by the avidity of cell surface clustered CD300lf."
< "Q6SJQ7-1","RefSeq","NP_001162624.1","18097021","These results indicate that CD300LF mediates caspase and endoplasmic reticulum stress-independent cell death by a novel mechanism."
< "Q6SJQ7-1","RefSeq","NP_001162624.1","17438331","The innate immune system is at least in part regulated by the qualitative and quantitative balance of the paired receptors LMIR3 and LMIR4"
< "Q6SJQ7-1","RefSeq","NP_001162624.1","16794255","DIgR2 is a functionally inhibitory receptor and can mediate negative signaling to regulate DC-initiated antigen-specific T-cell responses."
< "Q9JIY2-1","RefSeq","NP_001240776.1","19535458","Results suggest that Hakai is an important regulator of cell proliferation and that Hakai may be an oncoprotein and a potential molecular target for cancer treatment."
< "Q9JIY2-1","RefSeq","NP_001240776.1","12165405","E-cadherin distribution and expression is altered in utricle epithelia with induction of apoptosis."
< "O70589-1","RefSeq","NP_001271432.1","28234597","CASK T740A mutation attenuated the interaction between CASK and TBR1 in the brain. However, CASK T740A mice were generally healthy, without obvious defects in brain morphology. The most dramatic defect among the mutant mice was in extinction of associative memory, though acquisition was normal."
< "O70589-1","RefSeq","NP_001271432.1","27036546","Ths data of this study implies that some phenotypic components of CASK heterozygous deletion mutation associated disorders represent systemic manifestation of metabolic stress. Publication Status: Online-Only"
< "P60762-1","RefSeq","NP_001034236.1","27573846","In round spermatids, MRG15 colocalizes with splicing factors PTBP1 and PTBP2 at H3K36me3 sites between the exons and single intron of transition nuclear protein 2 (Tnp2). Thus, our results reveal that MRG15 is essential for pre-mRNA splicing during spermatogenesis and that epigenetic regulation of pre-mRNA splicing by histone modification could be useful to understand not only spermatogenesis but also, epigenetic disorder"
< "P60762-1","RefSeq","NP_001034236.1","24451372","HDAC2-dependent deacetylation of MORF4L1 enhances MORF4L1 homodimerization, thus facilitating the functionality of complex formation to repress cell proliferation. Erratum:[J Biol Chem. 2014 Sep 5;289(36):24943]"
16098a21672,21675
> "Q9DBA9-1","RefSeq","NP_032212.3","24173291","Mice with a liver overexpression of insulin-like growth factor 2 (IGF2) mRNA-binding protein p62/IMP2-2/IGF2BP2-2 show elevated Ccl2 levels, which models all stages of non-alcoholic fatty liver disease."
> "Q9DBA9-1","RefSeq","NP_032212.3","23872361","We propose that autophagy is inhibited in the alphaB-R120G mutant lenses because of a defect in protein degradation after autophagosome formation."
> "Q9DBA9-1","RefSeq","NP_032212.3","21659648","P62 is up-regulated in mouse proteinopathic hearts and promotes aggresome formation and autophagy activation and protects cardiomyocytes against proteotoxic stress"
> "Q9DBA9-1","RefSeq","NP_032212.3","20974803","Cdk1 phosphorylates p62 in vitro and in vivo at T269 and S272, which is necessary for the maintenance of appropriate cyclin B1 levels and the levels of cdk1 activity necessary to allow cells to properly enter and exit mitosis. Erratum:[Mol Cell Biol. 2011 Feb;31(3):599]"
16118a21696,21701
> "Q3UMR0-1","RefSeq","NP_839994.1","27066885","RACK1 competes with Rab40C for binding to the ANKR2 domain of Varp and regulates dendrite outgrowth through stabilization of Varp in mouse melanocytes"
> "Q3UMR0-1","RefSeq","NP_839994.1","19403694","Varp functions as the Rab32/38 effector that controls trafficking of Tyrp1 in melanocytes."
> "Q3UMR0-1","RefSeq","NP_839994.1","16525121","Varp is a potential Rab21 guanine nucleotide exchange factor and might regulate endosome dynamics in vivo"
> "Q9DBR7-1","RefSeq","NP_082168.1","30446640","The findings define the PI3K/NUAK1/MYPT1/MLCP axis as a critical pathway to regulate actomyosin contractility in endothelial cells, supporting vascular patterning and expansion through the control of cell rearrangement. Publication Status: Online-Only"
> "Q9DBR7-1","RefSeq","NP_082168.1","27129938","Revealed the presence of two MYPT1 isoforms, full length and variant 2 in human intestinal (Caco-2) epithelial cells and isolated intestinal epithelial cells from mice"
> "Q9DBR7-1","RefSeq","NP_082168.1","27084390","Mypt1 E24 splice variants tune arterial reactivity and could be worthy targets for lowering vascular resistance in disease states."
16132,16134c21715,21718
< "P13864-1","RefSeq","NP_001186360.2","21163962","Structure of DNMT1 composed of CXXC, tandem bromo-adjacent homology (BAH1/2), and methyltransferase domains bound to DNA-containing unmethylated CpG sites; studies identify an autoinhibitory mechanism of DNA methylation"
< "P13864-1","RefSeq","NP_001186360.2","17371843","Data suggest that the biological functions of DNA methyltransferase 1 are exerted through the methylation of DNA."
< "P13864-1","RefSeq","NP_001186360.2","15634679","This enzyme is a target of DNA methylation in embryogenesis."
---
> "Q8R4F0-1","RefSeq","NP_598921.1","29453205","Mice lacking both mucolipins 3 and 1, but not either one alone, experienced hearing loss as early as at 1 month of age."
> "Q8R4F0-1","RefSeq","NP_598921.1","26027738","Study shows that, when uropathogenic E. coli infect bladder epithelial cells, they are targeted by autophagy but avoid degradation because of their capacity to neutralize lysosomal pH. This change is detected by TRPML3, TRPML3 activation then spontaneously initiates lysosome exocytosis, resulting in expulsion of exosome-encased bacteria."
> "Q8R4F0-1","RefSeq","NP_598921.1","25521295","Lack of both mucolipins 1 and 3 causes an accelerated mucolipidosis IV-type of vacuolation in enterocytes Publication Status: Online-Only"
> "Q8R4F0-1","RefSeq","NP_598921.1","21344404","Results describe the expression and subcellular distribution of TRPML3 in the inner ear as well as in other sensory organs."
16137c21721,21732
< "Q69ZA1-1","RefSeq","NP_001074527.1","24999027","The findings of this study suggest that Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression."
---
> "Q8BWB6-1","RefSeq","NP_083010.2","29940176","The conformational modulation of STEAP2 by the local membrane cholesterol content can therefore serve as a potential mechanism to modulate STEAP2 function in a compartment-restricted manner"
> "Q8BWB6-1","RefSeq","NP_083010.2","23874564","Stamp1 and Stamp2 play critical roles in adipogenesis, but through different mechanisms. Publication Status: Online-Only"
> "Q8BWB6-1","RefSeq","NP_083010.2","19196137","STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice."
> "Q6V5K9-1","RefSeq","NP_080025.3","17971504","Zfp474 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
> "Q6P6J4-1","RefSeq","NP_778181.2","26930515","These results revealed that N3-ethylthymidine , but not other DNA lesions, could be repaired by Alkbh2 and Alkbh3 in mammalian cells."
> "Q6P6J4-1","RefSeq","NP_778181.2","22684101","ALKBH2 and ALKBH3 provide cancer protection similar to that of the DNA glycosylase AAG and display apparent epistasis with Aag"
> "Q6P6J4-1","RefSeq","NP_778181.2","22429847","Although both Alkbh2 and Alkbh3 can protect against methyl methanesulfonate-induced cell death, only Alkbh2 shows statistically significant protection against mutations following treatment with this exogenous methylating agent."
> "Q9JLV5-1","RefSeq","NP_057925.1","30261176","Kelch-like ECH-associated protein 1 (Keap1) is a cullin-3 (Cul3)-RING ubiquitin ligase (CRL) adaptor/scaffold protein."
> "Q9JLV5-1","RefSeq","NP_057925.1","29869755","Decreased abundance of KLHL3 is a specific phenomenon caused by mutant CUL3 (Deltaexon9)."
> "Q9JLV5-1","RefSeq","NP_057925.1","29897280","Deletion of exon 9 from Cul3 generates a protein that is itself ubiquitin-ligase defective but also capable of enhanced autophagocytic KLHL3 degradation"
> "Q9JLV5-1","RefSeq","NP_057925.1","29777060","High Cullin 3 expression is associated with atherogenesis."
> "Q9JLV5-1","RefSeq","NP_057925.1","17339333","Data show that the constitutive degradation pathway for cyclin E that is regulated by the Cullin3-based E3 ligase is essential to maintain quiescence in mammalian cells."
16140a21736,21738
> "Q05921-1","RefSeq","NP_036012.1","27831565","Pref-1 mRNA is a novel substrate of RNase-L. Publication Status: Online-Only"
> "Q05921-1","RefSeq","NP_036012.1","26739051","Thus, activation of RNase L does not require mouse hepatitis virus virus-induced interferon but rather correlates with adequate levels of basal Oas gene expression, maintained by basal interferon signaling. Publication Status: Online-Only"
> "Q05921-1","RefSeq","NP_036012.1","26517238","RNAse L stimulates fibroblast migration."
16141a21740,21747
> "Q7TSH3-1","RefSeq","NP_898854.1","29846698","Zfp217 and Zfp516 facilitate Ctbp2-mediated repression on active embryonic stem cell genes during differentiation."
> "Q7TSH3-1","RefSeq","NP_898854.1","27264172","Through interaction with Zfp516, LSD1 is recruited to UCP1 and other brown adipose tissue-enriched genes."
> "Q7TSH3-1","RefSeq","NP_898854.1","25578880","Zfp516 directly binds to the proximal region of the UCP1 promoter, not to the enhancer region where other transcription factors bind, and interacts with PRDM16 to activate the UCP1 promoter."
> "O88909-1","RefSeq","NP_112471.3","29412698","OAT3 increases the glucosuric effect of empagliflozin, which may relate to the partial overlap of its localization with SGLT2 and thus OAT3-mediated tubular secretion of empagliflozin in the early proximal tubule."
> "O88909-1","RefSeq","NP_112471.3","29243851","Vitamin D-deficiency resulted in down-regulation of liver Cyp7a1 and renal Oat3, conditions that are alleviated upon replenishment of cholecalciferol."
> "O88909-1","RefSeq","NP_112471.3","28765282","OAT1 plays a greater role in kidney proximal tubule metabolism and OAT3 appears relatively more important in systemic metabolism, modulating levels of metabolites flowing through intestine, liver, and kidney"
> "O88909-1","RefSeq","NP_112471.3","28689374","OCT2-independent pathway of cisplatin-induced renal injury that is mediated by the organic anion transporters OAT1 and OAT3, is reported."
> "O88909-1","RefSeq","NP_112471.3","12011098","Oat3 plays a key role in systemic detoxification and in control of the organic anion distribution in cerebrospinal fluid (Oat3 = SLC22A8 transporter)"
16155,16157c21761,21762
< "Q61481-4","RefSeq","NP_001153054.1","28750036","These results support an important role of PDE1A in the renal pathogenesis of autosomal dominant polycystic kidney disease and in the regulation of blood pressure. Publication Status: Online-Only"
< "Q61481-4","RefSeq","NP_001153054.1","22012077","These results suggest that induction of PDE1A plays a critical role in cardiac fibroblast activation and cardiac fibrosis"
< "Q61481-4","RefSeq","NP_001153054.1","15901640","New variant PDE1A_v7 is the major form of cyclic nucleotide phosphodiesterase 1A expressed in mature sperm and is therefore likely to play an important role in cyclic nucleotide regulation of mature sperm function."
---
> "Q8K3Q3-1","RefSeq","NP_683737.2","16020526","Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord."
> "Q8K3Q3-1","RefSeq","NP_683737.2","11520680","Expressed during neural development in the retina, the ventral hindbrain and spinal cord and dorsal midbrain"
16163a21769
> "Q9JI38-1","RefSeq","NP_075781.3","17170069","Pus1p- and Pus3p-dependent pseudouridylation of SRA controls a coactivator-corepressor switch in SRA with major consequences for NR signaling."
16214a21821,21831
> "Q8BG84-1","RefSeq","NP_848726.1","30217615","Collagen degradation fragments inhibit osteoclast formation acting through LAIR-1, providing a novel mechanism for the physiologically-relevant negative control of osteoclastogenesis"
> "Q8BG84-1","RefSeq","NP_848726.1","29884698","This study shows that LAIR1 inhibits Th1 Responses but Is required for natural and induced monocyte-dependent Th17 responses"
> "Q8BG84-1","RefSeq","NP_848726.1","29269840","Absence of LAIR-1 in myocardial infarct mice does not influence infarct size, inflammation, fibrosis or adverse cardiac remodelling. Publication Status: Online-Only"
> "Q8BG84-1","RefSeq","NP_848726.1","28887430","These data demonstrate that collagen can suppress the T cell cytokine response through the action of LAIR-1, and that LAIR-1-/- mice develop more severe arthritis"
> "Q8BG84-1","RefSeq","NP_848726.1","28336561","LAIR-1 in megakaryocytes leads to increased Src family kinase activity and downstream signaling in response to collagen that is transmitted to platelets, rendering them hyper-reactive specifically to agonists that signal through Syk tyrosine kinases."
> "Q8BG84-1","RefSeq","NP_848726.1","15100296","Mouse Lair-1 cytoplasmic tail can become phosphorylated, thereby recruiting SH2-containing tyrosine phosphatase-2 (SHP-2). Unlike human LAIR-1, SHP-1 is not recruited to the mouse Lair-1 cytoplasmic tail."
> "Q9WTZ2-1","RefSeq","NP_062683.3","26719336","Data (including data from studies in knockout mice) suggest osteocyte Mbtps1 expression is involved in development of sarcopenia in slow-twitch muscle fibers; Mbtps1 knockout mice (conditional osteocyte deletion) do not develop sarcopenia of aging."
> "Q9WTZ2-1","RefSeq","NP_062683.3","26108224","S1P substrate-dependent regulatory mechanisms for lipid synthesis and biogenesis of lysosomes are different"
> "Q9WTZ2-1","RefSeq","NP_062683.3","25652402","A novel role for MBTPS1/SKI-1/S1P (membrane bound transcription factor protease, subtilisin kexin isozyme-1, or site 1 protease) in somite segmentation and in the pathogenesis of vertebral anomalies."
> "Q9WTZ2-1","RefSeq","NP_062683.3","25147951","These studies indicate an indispensable role for S1P in type IIB procollagen trafficking from the ER. Publication Status: Online-Only"
> "Q9WTZ2-1","RefSeq","NP_062683.3","12180344","Located distally on chromosome 8."
16223a21841,21842
> "Q9Z140-1","RefSeq","NP_034077.1","27194588","Links activity-triggered calcium signals to spine structural plasticity necessary for learning and memory Publication Status: Online-Only"
> "Q9Z140-1","RefSeq","NP_034077.1","26175110","The second C2-domain of copine-6 is responsible for calcium-dependent membrane association."
16229,16230c21848,21856
< "Q9JL16-1","RefSeq","NP_001278149.1","30232164","ISG20 upregulated IFIT1 genes and inhibited translation of the alphavirus genome. Furthermore, IFIT1-sensitive alphavirus replication was increased in Isg20(-/-) mice compared to the replication of wild-type viruses but not in cells ectopically expressing ISG20. Publication Status: Online-Only"
< "Q9JL16-1","RefSeq","NP_001278149.1","19321657","Suggest that the recruitment of peripheral CXCR4-expressing ITGA2(+)ISG20(+) NK cells into pregnant uteri may be important in the regulation of feto-maternal tolerance."
---
> "Q8K136-1","RefSeq","NP_081289.2","17656373","Scnm1 is the first example of a modifier gene which influences disease severity through a trans-effect on splicing of the disease gene transcript."
> "Q8K136-1","RefSeq","NP_081289.2","13679025","Variation between inbred strains of mice can be used to identify modifier genes affecting the susceptibility to inherited disease.  The severity of the neurological disorder is determined by the modifier locus Scnm1."
> "Q6PAL8-1","RefSeq","NP_067469.1","21543860","In contrast to wild-type R6IP1-Rab6 crystals, which took several weeks to grow to full size, the engineered R6IP1 (RPdel)-Rab6 crystals could be grown in a matter of days"
> "Q6PAL8-1","RefSeq","NP_067469.1","17725553","May couple Rab6 and Rab11 function throughout the cell cycle; R6IP1 overexpression alters the distribution of peripheral recycling endosomes."
> "P30935-1","RefSeq","NP_033244.2","26503786","Results implicate beta-arrestin in the modulation of Sstr3 ciliary localization and further suggest a role for beta-arrestin in the mediation of Sstr3 ciliary signaling. Publication Status: Online-Only"
> "P30935-1","RefSeq","NP_033244.2","25149275","The expression and localization of the three receptors (SSTR3-SSTR5) in wild-type (WT), single-knockout (SSTR1 KO) and double-knockout SSTR1/SSTR2 (DKO) mice, are reported."
> "P17182-1","RefSeq","NP_075608.2","30242159","Regulates the metabolic reprogramming and malignant phenotype of pulmonary artery smooth muscle cells in pulmonary arterial hypertension Publication Status: Online-Only"
> "P17182-1","RefSeq","NP_075608.2","28525970","This paper shows the immunoregulatory role of alpha enolase in dendritic cell function during Chlamydia infection Publication Status: Online-Only"
> "Q8K561-1","RefSeq","NP_647471.1","11972037","Otoancorin is defective in autosomal recessive deafness DFNB22"
16239a21866,21881
> "Q8R138-1","RefSeq","NP_666274.1","22416756","Obif plays an essential role in bone formation through regulating osteoblastogenesis."
> "Q8R138-1","RefSeq","NP_666274.1","21239498","Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway."
> "Q8R138-1","RefSeq","NP_666274.1","20025746","Study identifies a novel gene, obif (osteoblast induction factor), encoding a transmembrane protein that is predominantly expressed in osteoblasts. Publication Status: Online-Only"
> "Q9D711-1","RefSeq","NP_081429.1","21801495","Sod1(-/-) mice have a significantly elevated level of Pir mRNA in the spleen and kidney but not in the liver, heart, or/and brain."
> "Q9D711-1","RefSeq","NP_081429.1","19372376","Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~38%."
> "Q6ZPR4-1","RefSeq","NP_780671.2","29859980","As deficits in social behaviors seem to occur independently from each other in FMRP and Slack null mutants, we conclude that Slack is not involved in the autistic phenotype of FMRP KO mice."
> "Q6ZPR4-1","RefSeq","NP_780671.2","26587966","The highest Slack channel expression was detected in the olfactory bulb, lateral septal nuclei, basal ganglia, and distinct areas of the midbrain, brainstem, and cerebellar cortex."
> "Q6ZPR4-1","RefSeq","NP_780671.2","26559620","The authors find that knockout of Slo2.2, but not Slo2.1, results in enhanced itch and pain responses. Publication Status: Online-Only"
> "Q6ZPR4-1","RefSeq","NP_780671.2","17344399","Slick and Slack are expressed at high levels auditory brainstem. Activation of these KNa channels allows temporal accuracy of firing to be increased at high frequencies of stimulation."
> "Q6ZPR4-1","RefSeq","NP_780671.2","16446508","This is the first demonstration of an epithelial cell membrane, Na+-activated, large-conductance K+ channel resembling K(Na) channels of excitable cells. The Slo2.2 type, Na+- and Cl--activated K+ channel is located in the ascending limb of the kidney."
> "Q6ZPR4-1","RefSeq","NP_780671.2","14559234","Partly colocalized with PSD-95 in mouse neocortical neurons"
> "E9Q649-1","RefSeq","NP_001159537.1","22736280","N-acetylglucosaminyltransferase IVa regulates metastatic potential of mouse hepatocarcinoma cells through glycosylation of CD147."
> "Q9Z191-1","RefSeq","NP_001334301.1","26499333","Results implicate Eya4/Six1 regulates normal cardiac function via p27/casein kinase-2alpha/histone deacetylase 2 and indicate that mutations within this transcriptional complex and signaling cascade lead to the development of cardiomyopathy."
> "Q9Z191-1","RefSeq","NP_001334301.1","19561593","That Eyes absent 4 (EYA4), originally identified as a co-transcription factor, stimulates the expression of IFN-beta and CXCL10 in response to the undigested DNA of apoptotic cells"
> "Q9Z191-1","RefSeq","NP_001334301.1","18219393","Eya4(-/-) mice developed otitis media with effusion; anatomic studies revealed abnormal middle ear cavity and eustachian tube dysmorphology."
> "Q9Z191-1","RefSeq","NP_001334301.1","15492887","Constructs of the homologous region ( Eya1HR and Eya4HR) interact with Six1 prey constructs, although no interaction with Dach1 prey was demonstrable"
16244a21887
> "Q8VE65-1","RefSeq","NP_079855.2","23426901","ATF7 interacts with TAF12 and contributes to the hypersensitivity of OCL precursors to 1,25-(OH)D in PD."
16249a21893,21897
> "Q9D0Z3-1","RefSeq","NP_083865.1","17971504","Tmem53 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
> "O35457-1","RefSeq","NP_059494.2","29242308","Ccrl2 modulates chemerin levels in the epithelial lining fluid of the lungs but does not contribute to the development of O3-induced lung pathology."
> "O35457-1","RefSeq","NP_059494.2","28743719","Upregulation of CCRL2 observed under inflammatory conditions is functional to finely tune CXCR2-mediated neutrophil recruitment at sites of inflammation."
> "O35457-1","RefSeq","NP_059494.2","28600126","CCRL2 mRNA was not significantly changed in murine and human non-alcoholic steatohepatitis liver. CCRL2 was related to the mRNA levels of F4/80, transforming growth factor beta and alpha smooth muscle actin in murine non-alcoholic steatohepatitis."
> "O35457-1","RefSeq","NP_059494.2","26744451","Chemokine (CC motif) receptor-like 2 should be considered to be a molecule involved in the regulation of the inflammatory response associated with multiple sclerosis."
16254d21901
< "Q8BLQ9-1","RefSeq","NP_001334176.1","29217450","Cadm2 expression regulates body weight and glucose homeostasis."
16256,16265c21903,21916
< "Q3U108-1","RefSeq","NP_001165676.1","29244194","Arid5a regulates the augmentation of OX40 in CD4+ T cells, and impairs destabilizing functions of Regnase-1 and Roquin-1 on OX40 alternative decay element-like stem-loop in the 3' untranslated region"
< "Q3U108-1","RefSeq","NP_001165676.1","29358370","High Arid5a expression is associated with inflammation."
< "Q3U108-1","RefSeq","NP_001165676.1","28168301","Data showed that regulation of Arid5a by NF-kappaB and MAPK signaling is required to maintain the balance of IL-6 mRNA expression"
< "Q3U108-1","RefSeq","NP_001165676.1","28379390","This study shows that Arid5a-deficient mice were highly refractory to bleomycin-induced lung injury"
< "Q3U108-1","RefSeq","NP_001165676.1","27671645","Arid5a deficiency resulted in decreased levels of IFN-gamma under Th1 cell conditions, in which T-box expressed in T cells (T-bet) mRNA expression was inhibited."
< "Q3U108-1","RefSeq","NP_001165676.1","27022145","T cell-intrinsic role of Arid5a on fate decisions of naive CD4(+)T cells through selective stabilization of Stat3 mRNA."
< "Q3U108-1","RefSeq","NP_001165676.1","23676272","Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo."
< "Q3U108-1","RefSeq","NP_001165676.1","21346191","AT-rich interactive domain-containing protein 5a (Arid5a) cooperates with Sox9 to stimulate chondrocyte-specific transcription."
< "Q8CH25-1","RefSeq","NP_079966.2","30782847","SLTM regulates GLI factor binding to chromatin and contributes to the transcriptional outcomes of SHH signaling via a novel molecular mechanism."
< "Q8CH25-1","RefSeq","NP_079966.2","17630952","Inhibition of gene expression by STLM appears to result from generalized down-regulation of mRNA synthesis and initiation of apoptosis following SLTM overexpression."
---
> "Q9CQN6-1","RefSeq","NP_079663.1","25157825","TMEM14C facilitates the import of protoporphyrinogen IX into the mitochondrial matrix for heme synthesis and subsequent hemoglobin production"
> "Q9CQN6-1","RefSeq","NP_079663.1","19656490","Required for functional heme biosynthesis in erythroid cells."
> "Q3UI43-1","RefSeq","NP_080912.2","26338419","Merit40 mutation exacerbated ICL-induced chromosome instability in the context of concomitant Brca2 deficiency but not in conjunction with Fancd2 mutation."
> "Q3UI43-1","RefSeq","NP_080912.2","25636339","MERIT40(-/-) hematopoietic stem cells are more resistant to cytoablative stress, and exhibit superior repopulating ability and self-renewal upon serial transplantation."
> "O08917-1","RefSeq","NP_032053.1","29667320","Genetic Flot1 depletion augments chronic corticosterone-induced behavioral despair.  Flot-1 interacts with serotonin transporter."
> "O08917-1","RefSeq","NP_032053.1","29787576","Flotillins may directly or indirectly regulate cellular sphingolipid distribution and signaling by maintaining S1P levels Publication Status: Online-Only"
> "O08917-1","RefSeq","NP_032053.1","29162604","FLOT1 is a novel participant in the disposal of harmful remant lipoproteins via syndecan-1. Low expression of FLOT1 in T2DM liver may contribute to metabolic dyslipoproteinemia."
> "O08917-1","RefSeq","NP_032053.1","27346864","DJ-1 has a role in glutamate uptake into astrocytes by regulating flotillin-1 and caveolin-1 expression Publication Status: Online-Only"
> "O08917-1","RefSeq","NP_032053.1","27346727","Flotillin has a role in desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes Publication Status: Online-Only"
> "P49117-1","RefSeq","NP_035760.1","29228365","Notch4 inhibited Mycobacterium tuberculosis-induced production of proinflammatory cytokines by interaction with TAK1 and inhibition of its activation."
> "P49117-1","RefSeq","NP_035760.1","29776451","This study demonstrated that Myeloid-specific TAK1 deletion results in reduced brain monocyte infiltration and improved outcomes after stroke. Publication Status: Online-Only"
> "P49117-1","RefSeq","NP_035760.1","29291351","Our findings demonstrate that CYLD mitigates Nonalcoholic steatohepatitis severity and identify the CYLD-TAK1 axis as a promising therapeutic target for management of the disease."
> "P49117-1","RefSeq","NP_035760.1","29018082","We conclude that TR4 is required for the normal differentiation and proliferation of erythroid cells, in addition to its previously characterized roles in embryonic and fetal globin gene repression"
> "P49117-1","RefSeq","NP_035760.1","28974699","Our data suggest that NUMBL and TAK1 are reciprocally regulated and that NUMBL acts as an endogenous regulator of NF-kappaB signaling and osteoclastogenesis by targeting the TAK1-TRAF6-NEMO axis. Publication Status: Online-Only"
16266a21918,21919
> "Q9JMH9-3","RefSeq","NP_035716.1","27824130","MYO18A has the potential to form a multiprotein complex that links the Golgi apparatus to F-actin, which regulates muscle integrity and function during early development Publication Status: Online-Only"
> "Q9JMH9-3","RefSeq","NP_035716.1","25965346","Studies revealed a novel physical association between SP-R210S, CD14, and SR-A leading to an enhanced response to LPS, and found that SP-R210L and SP-R210S regulate internalization of CD14 via distinct macropinocytosis-like mechanisms Publication Status: Online-Only"
16269,16275c21922,21929
< "Q8BVZ1-1","RefSeq","NP_001070816.1","30954078","Our data highlight a protective role of Plin5 against hepatic lipotoxic injuries induced by HCV NS5A, which is helpful for understanding the steatosis and injuries in liver during HCV infection. Publication Status: Online-Only"
< "Q8BVZ1-1","RefSeq","NP_001070816.1","30617219","Study show that Plin5 is an important modulator of intrahepatic lipid metabolism and suggest that the increased Plin5 expression that occurs with overnutrition may play an important role in preventing hepatic insulin resistance."
< "Q8BVZ1-1","RefSeq","NP_001070816.1","29378767","Changes in lipid metabolism resulting from PLIN5 deletion reduce ER stress in muscle, decrease FGF21 production by muscle and liver, and impair glycemic control."
< "Q8BVZ1-1","RefSeq","NP_001070816.1","29317465","Perilipin 5 and liver fatty acid binding protein function to restore quiescence in mouse hepatic stellate cells"
< "Q8BVZ1-1","RefSeq","NP_001070816.1","28919478","The results indicated that atorvastatin promoted lipolysis and reduced TG accumulation in the liver by increasing PKA-mediated phosphorylation of Plin5. This new mechanism of lipid-lowering effects of atorvastatin might provide a new strategy for NAFLD treatment."
< "Q8BVZ1-1","RefSeq","NP_001070816.1","17234449","We have characterized a novel PAT protein, lipid storage droplet protein 5 (LSDP5) of 463 residues.The LSDP5 gene is primarily transcribed in cells that actively oxidize fatty acids, such as heart, red muscle and liver."
< "Q8BVZ1-1","RefSeq","NP_001070816.1","16571721","MLDP is a novel PAT family protein localized to lipid droplets and enriched in the heart, and regulated by peroxisome proliferator-activated receptor alpha"
---
> "Q99PV5-1","RefSeq","NP_077789.1","29926321","These results suggest that Bhlhe41 plays critical roles in regulating cell death and neurite outgrowth in N2a cells."
> "Q99PV5-1","RefSeq","NP_077789.1","29692408","Genetic deletion of SHARP1 in mice delays the development of leukemia and attenuated leukemia-initiating potential, while sparing normal hematopoiesis. Publication Status: Online-Only"
> "Q99PV5-1","RefSeq","NP_077789.1","29472596","This study identified P21 and Sharp1 as HDAC4 target genes. Publication Status: Online-Only"
> "Q99PV5-1","RefSeq","NP_077789.1","28250425","Bhlhe41 directly repressed the expression of cell-cycle regulators and inhibitors of BCR signaling while enabling pro-survival cytokine signaling. Thus, Bhlhe41 controls the development, BCR repertoire and self-renewal of B-1a cells."
> "Q99PV5-1","RefSeq","NP_077789.1","12657651","Functions as a transcriptional repressor of E box activity and Stra13 expression"
> "Q99PV5-1","RefSeq","NP_077789.1","12397359","Dec1 and Dec2 are regulators of the mammalian molecular clock, and form a fifth clock-gene family."
> "Q99PV5-1","RefSeq","NP_077789.1","12175508","MSharp-1 may regulate the differentiation of several cell types during vertebrate development"
> "Q8C0P5-1","RefSeq","NP_849224.2","21331046","Findings uncover a CORO2A-actin-dependent mechanism for the de-repression of inflammatory response genes that can be differentially regulated by phosphorylation and by nuclear receptor signalling pathways that control immunity and homeostasis"
16279a21934,21942
> "Q3UTH8-1","RefSeq","NP_001277314.1","30087324","Collybistin binds the GABAAR-alpha2-subunit with high affinity Publication Status: Online-Only"
> "Q3UTH8-1","RefSeq","NP_001277314.1","29069083","Results uncover previously unexpected role for CB isoforms downstream of alpha2-containing GABAARs during neuron maturation in a Cdc42 dependent mechanism. Publication Status: Online-Only"
> "Q3UTH8-1","RefSeq","NP_001277314.1","25082542","Within this network, collybistin can adopt open/active and closed/inactive conformations to act as a switchable adaptor that links gephyrin to plasma membrane phosphoinositides."
> "Q3UTH8-1","RefSeq","NP_001277314.1","19236916","Data provide the first evidence that collybistin deficiency leads to significant changes of GABAergic inhibition, network excitability and synaptic plasticity in vivo."
> "Q3UTH8-1","RefSeq","NP_001277314.1","17690689","Cb is essential for gephyrin-dependent clustering of a specific set of GABA(A) receptors, but not required for glycine receptor postsynaptic localization."
> "Q3UTH8-1","RefSeq","NP_001277314.1","16616186","The resolution crystal structure of the Cdc42-collybistin II complex reveals a novel conformation of the switch I region of Cdc42, and biochemical data indicate that gephyrin negatively regulates collybistin activity."
> "Q5SZA1-1","RefSeq","NP_659085.1","25972451","Suggest that murine NPT3 is a polyspecific organic anion transporter that is involved in circulation of urate throughout the body."
> "P47708-1","RefSeq","NP_035416.1","28636945","In mice, phosphorylation-regulated neutrophil polarization mechanism is driven by PKN1-mediated phosphorylation of a newly identified RAB21 effector RPH3A."
> "P47708-1","RefSeq","NP_035416.1","26679993","Rph3A interacts with GluN2A and PSD-95 forming a complex that regulates NMDARs stabilization at postsynaptic membranes. Publication Status: Online-Only"
16284d21946
< "Q91WT9-1","RefSeq","NP_659104.1","30110564","Functional studies revealed that NaHS administration improved muscle fatigability in CBS(+/-) mice. In conclusion, our work provides evidence that NaHS is beneficial in mitigating HHcy-mediated skeletal injury incited by oxidative/ER stress responses."
16288a21951,21955
> "Q3U1F9-1","RefSeq","NP_444412.2","27751872","Our findings illustrate that Cbp is an important regulator of Csk recruitment to the SFK Lyn in Eporesponsive erythroid cells."
> "Q3U1F9-1","RefSeq","NP_444412.2","26512138","PAG is constitutively phosphorylated in resting T cells and rapidly dephosphorylated once the TCR is engaged."
> "Q3U1F9-1","RefSeq","NP_444412.2","26372908","This study demonstrated that cbp increase in skeletal muscle in muscle atrophy."
> "Q3U1F9-1","RefSeq","NP_444412.2","12612075","PAG is a bona fide negative regulator of T-cell activation as a result of its capacity to recruit Csk."
> "O88587-1","RefSeq","NP_031770.2","28801594","These results suggest that COMT is an enzyme to maintain glucose homeostasis and 2-methoxyestradiol is a potential endogenous multi-target anti-diabetic candidate. Publication Status: Online-Only"
16305a21973
> "P0C5K0-1","RefSeq","NP_001186970.1","15289607","First described as a protein kinase and named SgK110 (Sugen Kinase 110) after its human ortholog."
16316,16318c21984,21985
< "Q6ZPI0-1","RefSeq","NP_001123656.1","26919559","Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis."
< "Q6ZPI0-1","RefSeq","NP_001123656.1","24097061","LncRNA-JADE is a key functional link that connects the DDR to histone H4 acetylation, and that dysregulation of lncRNA-JADE may contribute to breast tumorigenesis."
< "Q6ZPI0-1","RefSeq","NP_001123656.1","14612400","Exhibits a regulated expression during embryogenesis and localizes to the nucleus and/or cytoplasm of different cell types"
---
> "Q6RHR9-1","RefSeq","NP_034497.1","27707879","The interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure"
> "Q6RHR9-1","RefSeq","NP_034497.1","23523645","ARIP1 and ARIP2 are co-expressed in some nerve cells and their biological activities are distinct."
16319a21987,21989
> "P26883-1","RefSeq","NP_032045.1","28864813","Acute tacrolimus treatment transiently increases hepcidin in wild-type mice. FKBP12 preferentially targets the BMP receptor ALK2. ALK2 mutants defective in binding FKBP12 increase hepcidin expression in a ligand-independent manner, through BMP-SMAD signaling."
> "P26883-1","RefSeq","NP_032045.1","26865567","FKBP51 is a central mediator of chronic pain."
> "P26883-1","RefSeq","NP_032045.1","25053409","We demonstrate that FKBP12 and its ligands impact multiple aspects of muscle function."
16330,16332c22000,22009
< "Q9JII5-1","RefSeq","NP_001116076.1","23965306","Identification of Crem, Crisp2 and Pot1a as the natural substrates of DAZAP1 and show that DAZAP1 promotes the inclusion of specific exons in these genes."
< "Q9JII5-1","RefSeq","NP_001116076.1","23658607","The translation of the two Dazap1 transcripts is differentially regulated during spermatogenesis. Publication Status: Online-Only"
< "Q9JII5-1","RefSeq","NP_001116076.1","18669443","DAZAP1 is not only essential for spermatogenesis, but also required for the normal growth and development of mice."
---
> "Q9Z2X2-1","RefSeq","NP_058579.2","30109252","These studies show that Gank protein promotes hepatocyte proliferation by elimination of tumor-suppressor proteins. Publication Status: Online-Only"
> "Q9Z2X2-1","RefSeq","NP_058579.2","23376718","The present study clarified, at least partly, mechanisms of vascular tumorigenesis, and suggests that gankyrin might play a physiological role in hypoxic responses besides its roles as an oncoprotein."
> "Q9Z2X2-1","RefSeq","NP_058579.2","23172628","FXR prevents liver cancer by inhibiting the gankyrin promoter via C/EBPbeta-HDAC1 complexes, leading to subsequent protection of tumor suppressor proteins from degradation."
> "Q9Z2X2-1","RefSeq","NP_058579.2","20628200","Gankyrin is a key regulator of Ras-mediated activation of Akt through inhibition of the downstream RhoA/ROCK pathway and thus plays an essential role in Ras-induced tumorigenesis."
> "Q9Z2X2-1","RefSeq","NP_058579.2","17935131","Gankyrin oncoprotein has a role in progression of esophageal squamous cell carcinoma"
> "Q9Z2X2-1","RefSeq","NP_058579.2","17896003","Findings suggest that retinoblastoma protein degradation in Lmna-/- cells occurs by gankyrin and MDM2-independent mechanisms. Publication Status: Online-Only"
> "Q9CQP2-1","RefSeq","NP_079708.2","19650763","The sedlin mutations S73L, F83S and V130D cause SEDT by sedlin misfolding, whereas the D47Y mutation may influence normal TRAPP (transport protein particle) dynamics. Publication Status: Online-Only"
> "Q9CQP2-1","RefSeq","NP_079708.2","12361953","X-ray crystallography analysis of mouse SEDL"
> "P63213-1","RefSeq","NP_034445.1","27074662","It was concluded that GIRK2, through its dual responsiveness to G protein beta-gamma and Na+, mediates a form of neuronal inhibition that is amplifiable in the setting of excess electrical activity. Publication Status: Online-Only"
> "Q8VIB3-1","RefSeq","NP_061254.1","22700726","Coordinated participation of both ST3Gal-VI and ST3Gal-IV in the synthesis of functional selectin ligands."
16371a22049
> "P14152-1","RefSeq","NP_032644.3","27179783","These findings provide strong evidence that MDH1 plays a critical role in osteoclast differentiation and function via modulation of the intracellular energy status, which might affect AMPK activity and NFATc1 expression."
16377a22056,22059
> "Q69ZP3-1","RefSeq","NP_079856.2","25730884","PNKD KO mice, RIM1/2 protein levels are reduced and synaptic strength is impaired. Thus, PNKD is a novel synaptic protein with a regulatory role in neurotransmitter release"
> "Q69ZP3-1","RefSeq","NP_079856.2","22214848","These findings support the hypothesis that the PNKD protein functions to modulate striatal neuro-transmitter release in response to stress and other precipitating factors."
> "Q69ZP3-1","RefSeq","NP_079856.2","20040360","These findings suggest that silencing MR-1 protected mice myocardium against inflammatory injury induced by AngII by suppression of pro-inflammatory transcription factors NF-kappaB and AP-1 signaling pathway."
> "Q69ZP3-1","RefSeq","NP_079856.2","15496428","Paroxysmal non-kinesigenic dyskinesia (PNKD) is characterized by spontaneous hyperkinetic attacks that are precipitated by alcohol, coffee, stress and fatigue."
16379a22062,22064
> "L0N7N1-1","RefSeq","NP_001274108.1","30385851","This work reveals a novel association of Kif14 overexpression with lymphoma but suggests that Kif14 does not have as prominent a role in initiating cancer in other cell types as it does in accelerating tumour development in response to other oncogenic insults. Publication Status: Online-Only"
> "L0N7N1-1","RefSeq","NP_001274108.1","27270502","Data provide the first evidence that Kif14 can promote tumor formation in susceptible cells in vivo"
> "L0N7N1-1","RefSeq","NP_001274108.1","24949858","The ADP-bound form of the KIF14 motor domain reveals a dramatically opened ATP-binding pocket."
16382a22068,22069
> "Q9Z1D7-1","RefSeq","NP_057893.2","12860387","Cloning and characterization of its expression during spermatogenesis"
> "E9Q7D5-1","RefSeq","NP_598435.1","19713215","RhoA guanine nucleotide exchange factor Arhgef5 regulates immature dendritic cell migration"
16390,16393d22076
< "Q8BT07-1","RefSeq","NP_001157834.1","29683733","That Cep55 overexpression causes change in germ cell proportions and manifests as a Sertoli cell only tubule phenotype"
< "Q8BT07-1","RefSeq","NP_001157834.1","26582107","Cep55 may act as an MTOC-associated protein regulating spindle organization, and thus cell cycle progression during mouse oocyte meiotic maturation. Publication Status: Online-Only"
< "Q8BT07-1","RefSeq","NP_001157834.1","20176808","TEX14 prevents the completion of cytokinesis by altering the destiny of CEP55 from a nidus for abscission to an integral component of the intercellular bridge."
< "Q8BT07-1","RefSeq","NP_001157834.1","20186884","The results suggest that Cep55 and pericentrin are required for the stable bridge between germ cells during spermatogenesis and spermiogenesis."
16394a22078,22082
> "Q01147-1","RefSeq","NP_598589.2","31127098","Selective disruption of CREB function in medial prefrontal cortex (mPFC) engram cells after mild conditioning impairs remote memory expression. Memory consolidation by mPFC engram cells requires CREB-mediated transcription, with the functionality of this network hub being gated by memory strength. Publication Status: Online-Only"
> "Q01147-1","RefSeq","NP_598589.2","30822571","In model of vascular injury lncRNA-SRA promoted vascular smooth muscle cell proliferation by activating the MEK-ERK-CREB pathway."
> "Q01147-1","RefSeq","NP_598589.2","30709903","Iron down-regulates leptin by decreasing CREB glycosylation, resulting in increased CREB phosphorylation and leptin promoter occupancy by pCREB."
> "Q01147-1","RefSeq","NP_598589.2","31023055","Our data suggest that over expression of CREB may contribute to progression of glioma and knockdown of CREB expression may serve as a novel target for therapy"
> "Q9D892-1","RefSeq","NP_080198.2","27618981","The authors analysed ITPA-deficient human and mouse cells, and revealed that ITPA deficiency induces MLH1/PMS2- and p53-dependent growth arrest and DNA instability in mammalian cells. Publication Status: Online-Only"
16396a22085,22088
> "Q9Z2X1-1","RefSeq","NP_598595.1","29773655","FOXP3 represses the ability of hnRNPF to bind to its target pre-mRNA and thus modulates RNA alternative splicing"
> "Q9Z2X1-1","RefSeq","NP_598595.1","28424160","HnRNP F protects kidneys against oxidative stress and nephropathy via stimulation of Sirtuin-1 expression and signaling in diabetes."
> "Q9Z2X1-1","RefSeq","NP_598595.1","28324005","The beneficial actions of insulin in diabetic nephropathy appear to be mediated, in part, by suppressing renal Nrf2 and Agt gene transcription and preventing Nrf2 stimulation of Agt expression via hnRNP F/K."
> "Q9Z2X1-1","RefSeq","NP_598595.1","26232095","These data demonstrate that hnRNP F stimulates Ace-2 gene transcription, prevents TGF-beta1 inhibition of Ace-2 gene transcription and induction of kidney injury in diabetes."
16400,16404d22091
< "A2A432-1","RefSeq","NP_001103612.1","30992047","CUL4B level mediates HOX gene expression via histone H2A ubiquitination.  Aberrant CUL4B-mediated H2AK119ub1 level may be a risk factor for neural tube defects. Publication Status: Online-Only"
< "A2A432-1","RefSeq","NP_001103612.1","29106389","High CUL4B expression promotes gastric cancer invasion and metastasis."
< "A2A432-1","RefSeq","NP_001103612.1","28604389","A cullin 4B-RING E3 ligase complex fine-tunes pancreatic delta cell paracrine interactions"
< "A2A432-1","RefSeq","NP_001103612.1","17954973","Plays a conserved role in the regulation of beta-catenin levels."
< "A2A432-1","RefSeq","NP_001103612.1","16052071","The cloning and expression of amino and carboxy-terminal halves of cullin4B in mouse PCC4 cells is reported."
16417a22105,22106
> "Q9ERU3-1","RefSeq","NP_080333.1","14706453","Analysis revealed an intense expression of Krox-25 mRNA in rat and mouse teeth; results suggest that Krox-25 plays an important role as a transcription factor for the cytodifferentiation and amelogenesis of enamel epithelium."
> "Q9ERU3-1","RefSeq","NP_080333.1","14630903","Human gene locus mapping assoicated with permanent tooth agenesis"
16424a22114
> "Q8C9A2-3","RefSeq","NP_796368.1","27108838","Mouse Endonuclease V shares substrate preferences with human EndoV by catalyzing cleavage at inosines in RNA and being inert towards inosines in DNA. Publication Status: Online-Only"
16425a22116,22119
> "F8VPQ2-1","RefSeq","NP_001074664.1","23487765","ARID4A and ARID4B function as transcriptional coactivators for AR and RB and play an integral part in the AR and RB regulatory pathways involved in the regulation of Sertoli cell function and male fertility."
> "F8VPQ2-1","RefSeq","NP_001074664.1","18728284","Arid4a-deficient mice initially display ineffective hematopoiesis, followed by transition to chronic myelomonocytic leukemia (CMML)-like myelodysplastic/myeloproliferative disorder, and then transformation to AML."
> "F8VPQ2-1","RefSeq","NP_001074664.1","15750587","The retinoblastoma binding protein 1 shows a marked genomic instability, which is coincidental with decreased DNA methylation, increased acetylation of histone H3 and decreased tri-methylation of histone H4 at lysine 20 (H4K20)."
> "F8VPQ2-1","RefSeq","NP_001074664.1","14581478","RBP1 and the mSin3 histone deacetylase complex bind to BRMS1 and repress transcription"
16449a22144,22145
> "Q9R0Y1-1","RefSeq","NP_067345.1","24663811","Expression of acid-sensing ion channel 5 (asic5) in unipolar brush cells of the vestibulocerebellum Publication Status: Online-Only"
> "Q9R0Y1-1","RefSeq","NP_067345.1","20656685","RBLINaC is opened by an unknown ligand whereas mBLINaC is a constitutively open epithelial Na(+) channel."
16475a22172,22176
> "Q8BH64-1","RefSeq","NP_694708.2","29133341","EHD2 may be cardioprotective as a dominant-negative EHD2 mutant sensitized cardiomyocytes to ischemic damage. Our findings highlight EHD2 as a potential pharmacologic target in the treatment of diseases with KATP channel trafficking defects"
> "Q8BH64-1","RefSeq","NP_694708.2","28943089","EHD1, EHD2, and EHD4 are recruited to caveolae. Recruitment of the other EHDs increases markedly when EHD2, which has been previously detected at caveolae, is absent. Construction of knockout cell lines lacking EHDs 1, 2, and 4 confirms this apparent functional redundancy."
> "Q8BH64-1","RefSeq","NP_694708.2","28223496","The regulatory N-terminal residues and the EH domain keep the EHD2 dimer in an autoinhibited conformation in solution. By significantly advancing the use of infrared reflection-absorption spectroscopy, we demonstrate that EHD2 adopts an open conformation by tilting the helical domains upon membrane binding."
> "Q8BH64-1","RefSeq","NP_694708.2","14676205","Appears to connect endocytosis to the actin cytoskeleton through interactions of its N-terminal domain with membranes and its C-terminal EH domain with the novel EHBP1 protein"
> "Q6DFV1-1","RefSeq","NP_598523.3","16673016","The condensin II subunit MTB/mCAP-G2 plays a novel function during erythropoiesis"
16484c22185,22187
< "P70429-1","RefSeq","NP_001156866.1","28320969","EVL selectively mediate activated T-cell trafficking by promoting the diapedesis step of transendothelial migration in a alpha4 integrin-dependent manner."
---
> "P16297-1","RefSeq","NP_032394.1","30222140","Combined costimulatory and CD122 blockade improved survival of transplanted tissue in mice and nonhuman primates by controlling proliferation and effector function of CD8+ T cells."
> "P16297-1","RefSeq","NP_032394.1","29259102","Diabetes was accelerated in male and female NOD mice in which IL-2Rbeta signaling was modestly and selectively reduced in T cells. Publication Status: Online-Only"
> "P16297-1","RefSeq","NP_032394.1","29259099","The larger pool of IL-2Rbeta chains in CD8+ T cells is required to sustain IL-2 signaling and contributes to the quantitatively greater proliferative response to IL-2 relative to that of CD4+ mouse primary T cell cultures. Publication Status: Online-Only"
16494a22198,22199
> "Q7TMB8-1","RefSeq","NP_035500.2","30664619","Cyfip1 haploinsufficiency in mice led to decreased dendritic spine density and stability associated with social behavior and motor learning phenotypes. Behavioral training early in development resulted in alleviating the motor learning deficits caused by Cyfip1 haploinsufficiency. Publication Status: Online-Only"
> "Q7TMB8-1","RefSeq","NP_035500.2","14508708","Indentification on mouse chromosome 7C"
16500a22206,22209
> "Q3ULB5-1","RefSeq","NP_001139326.1","26375402","P21-activated kinase 6 (PAK6) as a novel interactor of leucine-rich repeat kinase 2 (LRRK2), a kinase involved in Parkinson's disease"
> "Q3ULB5-1","RefSeq","NP_001139326.1","23710594","Data suggest that PAK-6 p21-activated kinase plays a role in weight gain unrelated to exercise and caloric intake"
> "Q3ULB5-1","RefSeq","NP_001139326.1","23593460","Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice Publication Status: Online-Only"
> "Q3ULB5-1","RefSeq","NP_001139326.1","18675265","Our results indicate that Pak5 and Pak6 together are not required for viability, but are required for a normal level of locomotion and activity as well as for learning and memory."
16528a22238
> "P70225-1","RefSeq","NP_034680.3","20007572","Unlike humans, discrete transcripts encoding soluble and membrane forms of mouse IL-13Ralpha2 are both generated by alternative splicing."
16542a22253,22255
> "Q8BKX1-1","RefSeq","NP_570932.2","28067313","Double knockout of IRSp53 and its closest family member, IRTKS, resulted in exacerbated placental abnormalities, particularly in spongiotrophoblast differentiation and development, giving rise to complete embryonic lethality. Publication Status: Online-Only"
> "Q8VHM5-1","RefSeq","NP_083147.1","29507242","HnRNP R shapes the axonal transcriptome and its activity toward RNA localization is intricately linked to its main binding partner, noncoding RNA 7SK."
> "Q8VHM5-1","RefSeq","NP_083147.1","23967313","Heterogeneous nuclear ribonucleoprotein R cooperates with mediator to facilitate transcription reinitiation on the c-Fos gene. Publication Status: Online-Only"
16548a22262
> "P62951-1","RefSeq","NP_058612.3","18836209","Blcap is imprinted in mouse and human brain, but not in other mouse tissues."
16563a22278,22284
> "Q8BMP4-1","RefSeq","NP_084047.2","29876633","GPER with ERs and P450arom work in tandem to maintain Leydig cell architecture and supervise its steroidogenic function by estrogen during male life."
> "Q8BMP4-1","RefSeq","NP_084047.2","30149370","For the first time, we report here the importance of GPER-PPARalpha and -PPARgamma 'neopartnership' in maintenance of Leydig cell morpho-functional status."
> "Q8BMP4-1","RefSeq","NP_084047.2","29438359","In murine osteoblasts cultured in vitro, treatment with 17beta-estradiol resulted in the expression of GPR30 and enhanced mitophagy through the GPR30 and ERK1/2 signaling pathway. Publication Status: Online-Only"
> "Q8BMP4-1","RefSeq","NP_084047.2","28722236","It suppresses lipopolysaccharide-induced interleukin 6 via inhibition of nuclear factor-kappa B pathway in murine macrophage cells"
> "Q8BMP4-1","RefSeq","NP_084047.2","18063692","GPR30 is indispensable for thymocyte apoptosis that preferentially occurs in T-cell receptor beta chain double-positive thymocytes."
> "Q8BMP4-1","RefSeq","NP_084047.2","17379646","Results suggest that GPR30 functions as a plasma membrane receptor."
> "Q8BMP4-1","RefSeq","NP_084047.2","15511221","G protein-coupled receptor 30 down-regulates cofactor expression and interferes with the transcriptional activity of glucocorticoid"
16573a22295,22302
> "Q91ZE9-1","RefSeq","NP_612186.2","29749531","In clinical Esophageal squamous cell carcinoma (ESCC)specimens, BMF expression was upregulated, and negatively correlated with that of miR-125b. In conclusion, miR-125b had an antitumor role in ESCC cells mediated by targeting BMF, which can be potentially useful for tumorigenesis in ESCC"
> "Q91ZE9-1","RefSeq","NP_612186.2","28771225","Demonstrate that this sudden and dramatic loss of primordial follicles is hormonally triggered and identify the pro-apoptotic BH3-only protein, BCL-2 modifying factor (BMF), as essential for this process, implicating the intrinsic apoptotic pathway as a key mechanism. Publication Status: Online-Only"
> "Q3KNM2-1","RefSeq","NP_081590.3","27444773","These findings suggest that MITOL plays a protective role against apoptosis in cardiomyocytes."
> "Q3KNM2-1","RefSeq","NP_081590.3","26246171","MARCH5 binds MAVS only during viral stimulation when MAVS forms aggregates, and these interactions require the RING domain of MARCH5 and the CARD domain of MAVS. Publication Status: Online-Only"
> "Q3KNM2-1","RefSeq","NP_081590.3","26033541","March5 is involved in maintaining mouse-ESC (mESC) pluripotency via catalysis of Prkar1a polyubiquitination and inhibition of the Raf/MEK/ERK pathway. Publication Status: Online-Only"
> "Q3KNM2-1","RefSeq","NP_081590.3","24722297","A fine balance of Mfn1 levels is maintained by MARCH5-mediated quality control on acetylated Mfn1. Publication Status: Online-Only"
> "Q3KNM2-1","RefSeq","NP_081590.3","21625535","MARCH5 is an authentic E3 ubiquitin ligase and catalyzes K63-linked polyubiquitination of TANK. MARCH5 modulates TLR7 signaling via releasing the inhibitory action of TANK toward TRAF6."
> "Q3KNM2-1","RefSeq","NP_081590.3","19741096","Results indicate that MITOL plays a protective role against mitochondrial dysfunction caused by the mitochondrial accumulation of mSOD1 via the ubiquitin-proteasome pathway."
16576a22306,22311
> "P97435-1","RefSeq","NP_849186.2","23954298","Enteropeptidase could inhibit osteoclastogenesis in vitro through the cleavage of RANK."
> "P97435-1","RefSeq","NP_849186.2","1799406","Peptide sequencing of amino terminus of light chain of cow enterokinase, identifying the cleavage site"
> "O55239-1","RefSeq","NP_035054.1","30226369","By co-opting the enzymes of the methionine cycle, Nnmt aids the recycling of homocysteine to S-adenosylmethionine for another round of methylation."
> "O55239-1","RefSeq","NP_035054.1","29872122","These data indicate that NNMT links the NAD(+) and methionine metabolic pathways and promotes liver steatosis and fibrosis. Publication Status: Online-Only"
> "O55239-1","RefSeq","NP_035054.1","28720493","Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide have been presented."
> "O55239-1","RefSeq","NP_035054.1","24717514","NNMT is a novel regulator of histone methylation, polyamine flux and NAD(+)-dependent SIRT1 signalling, and is a unique and attractive target for treating obesity and type 2 diabetes"
16607a22343,22344
> "Q80XQ2-1","RefSeq","NP_082438.3","28602638","TBC1D5 shuttling to autophagosomes during metabolic stress facilitates retromer-dependent GLUT1 trafficking."
> "Q8C166-1","RefSeq","NP_733469.1","29101038","These data demonstrate that CPNE1 plays a key role in the regulation of neural stem cell functions through the activation of AKT-mTOR signaling pathway during brain development."
16611d22347
< "Q3U213-1","RefSeq","NP_001104487.1","15722415","Role in proximal t-haplotype mediated mouse sterility"
16614a22351
> "Q8R2Y9-1","RefSeq","NP_081533.1","22940690","Obfc2b deficiency does not affect initiation of DNA damage checkpoints, Atm activation, or the maintenance of genomic stability in B lymphocytes & primary fibroblasts. Its role in embryogenesis limited to cell types contributing to bone formation."
16626a22364,22366
> "S4R1W5-1","RefSeq","NP_035381.2","10965133","Rbm6 (def-3) maps to mouse chromosome 9F1-F2 two pseudogenes of def-3 map both to mouse chromosome 1"
> "S4R1W5-1","RefSeq","NP_035381.2","10460589","Rbm6 (def-3) was identified in a retroviral gene-trap screen"
> "S4R1W5-1","RefSeq","NP_035381.2","10353602","Rbm6 (def-3) defines a novel RNA-binding protein family"
16635c22375,22380
< "Q0P5V9-1","RefSeq","NP_001028391.2","25164149","MRNA expression of SLC45A2 in eyes and skin and of SLC45A3 primarily in the prostate, but also in other tissues, whereas SLC45A4 showed a predominantly ubiquitous expression"
---
> "Q5SSF7-1","RefSeq","NP_001136424.1","28931820","FAM46C protein is strongly induced during activation of primary splenocytes and that B lymphocytes isolated from newly generated FAM46C KO mice proliferate faster than those isolated from their WT littermates. Publication Status: Online-Only"
> "B2RY56-1","RefSeq","NP_081625.3","30635567","Tumor suppressive function in acute myeloid leukemia Publication Status: Online-Only"
> "O35640-1","RefSeq","NP_038501.2","25803307","Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium. Publication Status: Online-Only"
> "O35640-1","RefSeq","NP_038501.2","21344395","Define a distinct bone-dependent genetic program associated with terminal osteoclast differentiation and identified Anxa8 as a gene strongly induced late in osteoclast differentiation, regulating formation of the cell's characteristic actin ring."
> "O35640-1","RefSeq","NP_038501.2","17082908","ANXA8 protein is most abundant in stratified epithelia of the postnatal mouse. Its location in the suprabasal layers suggests that ANXA8 may be associated with the terminal differentiation of epithelial cells in these tissues."
> "O35640-1","RefSeq","NP_038501.2","16203777","Annexin A8 is involved in mouse mammary gland involution and progression of human breast cancer"
16650a22396,22404
> "Q9EP75-1","RefSeq","NP_071879.1","22969154","THE TOH-omega-hydroxylase activity was exhibited by microsomes from mouse and human small intestine; murine activity was entirely due to CYP4F14."
> "Q9EP75-1","RefSeq","NP_071879.1","22665481","CYP4F14 is the major but not the only vitamin E-omega-hydroxylase in mice"
> "Q9EP75-1","RefSeq","NP_071879.1","22160543","The data suggested that, in the absence of A2A adenosine receptor, omega-hydroxylase induces vasoconstriction through mitogen-activated protein kinases via upregulation of adenosine A1 receptor and protein kinase C-alpha."
> "Q9EP75-1","RefSeq","NP_071879.1","21466787","Catalytic activity of Cyp4fs is a novel target for modulating neuroinflammation through hydroxylation of LTB(4)."
> "Q64112-1","RefSeq","NP_032358.1","29666281","The authors provide evidence that IFIT2 increases the pathological effects of invasive Candida albicans and that administration of interferon-beta has deleterious effects during infection. Publication Status: Online-Only"
> "Q64112-1","RefSeq","NP_032358.1","28651122","This study shows that activation of IRF3 contributes to IFN-gamma and ISG54 expression during the immune responses to B16F10 tumor growth"
> "Q64112-1","RefSeq","NP_032358.1","28637751","Ifit2 exerts its antiviral effect mainly at the level of viral replication, as opposed to functioning as a mechanism that restricts viral entry/egress or transports rabies virus particles through axons. Publication Status: Online-Only"
> "Q64112-1","RefSeq","NP_032358.1","27137933","The mechanism for the observed differential induction of the mouse Ifit1, Ifit2, and Ifit3 genes in B cells and demonstrated that the repressive effect of the transcription factor interferon regulatory factor 8 (IRF8), which is highly expressed in B cells, played an essential role in this regulation."
> "Q64112-1","RefSeq","NP_032358.1","17030862","IFIT2/GARG39 was identified as a microtubule-associated protein enriched in the mitotic spindle of mouse NIH3T3 and B16F10 melanoma cells."
16657a22412
> "Q504M2-1","RefSeq","NP_001019777.1","30150402","ICER was found to bind to the Pdp2 promoter and suppress its expression. Furthermore, forced expression of PDP2 in CD4(+) cells reduced the in vitro Th17 differentiation, whereas shRNA-based suppression of PDP2 expression increased in vitro Th17 differentiation"
16659a22415
> "P26231-1","RefSeq","NP_033948.1","29923116","AlphaE-catenin knockout caused heart failure, the upregulation of hypertrophic genes, and the dysregulation of fatty acid metabolism via the transcriptional activity of Yap and beta-catenin. Erratum:[Pflugers Arch. 2018 Jul 4;:. PMID: 29971601]"
16662a22419,22422
> "Q60936-1","RefSeq","NP_075830.2","27499294","Loss of COQ8a results in cerebellar ataxia and coenzyme Q deficiency."
> "Q9CQJ7-1","RefSeq","NP_038945.2","28658604","Smurf1 interacts with and targets Securin, an inhibitor of sister-chromatid separation, for poly-ubiquitination and proteasomal degradation."
> "Q9CQJ7-1","RefSeq","NP_038945.2","28516917","The findings show that maternal aging compromises the oocyte SAC-APC/C axis leading to a decrease in securin that ultimately causes sister chromatid cohesion loss. Publication Status: Online-Only"
> "Q9CQJ7-1","RefSeq","NP_038945.2","27524416","High PTTG1 expression is associated with pituitary tumor development."
16667a22428,22432
> "P97819-1","RefSeq","NP_058611.1","30088174","PLA2G6 mutation causes degeneration of substantia nigra dopaminergic neurons by causing mitochondrial dysfunction, elevated endoplasmic reticulum stress, mitophagy impairment, and transcriptional abnormality."
> "P97819-1","RefSeq","NP_058611.1","28655161","Two members of dynamical network biomarke, PLA2G6 and CYP2C44 were found to induce dysfunction of arachidonic acid metabolism and finally lead to impairments of liver detoxification and malignant transition to cancer."
> "P97819-1","RefSeq","NP_058611.1","27789386","The antinociceptive effect of maprotiline was abrogated by iPLA2 antisense oligonucleotide injection to the prefrontal cortex, indicating a role of this enzyme in antinociception. In contrast, injection of iPLA2 antisense oligonucleotide to the somatosensory cortex did not reduce the antinociceptive effect of maprotiline."
> "P97819-1","RefSeq","NP_058611.1","15024020","IPLA(2)beta and iPLA(2)gamma are required for the adipogenic program that drives resting 3T3-L1 cells into adipocytes after hormone stimulation"
> "P97819-1","RefSeq","NP_058611.1","12167650","These findings support an RNA-dependent protein kinase-independent signaling role for iPLA(2) in the antiviral response of macrophages and the stimulation of inducible nitric oxide synthase expression."
16670a22436,22445
> "Q00196-1","RefSeq","NP_035268.2","26993806","Findings, combined with the predominantly B-cell-restricted expression of OCT2 and the absence of a systemic phenotype in our knockout mice, suggest that an OCT2-targeted therapeutic strategy would be efficacious in both major subtypes of DLBCL while avoiding systemic toxicity"
> "Q00196-1","RefSeq","NP_035268.2","26361887","Overexpression of DDX60 did not potentiate IFN induction"
> "Q00196-1","RefSeq","NP_035268.2","26016715","Oct2 mRNA expression was decreased in mice with either the ob/ob model or the methionine/choline deficiency model of nonalcoholic steatohepatitis."
> "Q9JJF9-1","RefSeq","NP_075709.2","30127434","Sppl2a-/- mice lack conventional dendritic cells, have CD4+ T cells that produce small amounts of IFN-gamma after BCG infection, and are highly susceptible to infection with BCG or Mycobacterium tuberculosis"
> "Q9JJF9-1","RefSeq","NP_075709.2","26987812","Study propose that elements within the transmembrane segment and the luminal juxtamembrane domain facilitate intramembrane proteolysis of CD74 by SPPL2a."
> "Q9JJF9-1","RefSeq","NP_075709.2","23426979","Intramembrane proteolysis by SPPL2A is essential for maintaining cellular homeostasis of ameloblasts."
> "Q9JJF9-1","RefSeq","NP_075709.2","23267016","B cell survival and dendritic cells function requires SPPL2A."
> "Q9JJF9-1","RefSeq","NP_075709.2","23267015","Sppl2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain."
> "Q9JJF9-1","RefSeq","NP_075709.2","23267013","Sppl2a is required for B cell and dendritic cells development and survival."
> "Q9JJF9-1","RefSeq","NP_075709.2","21896273","Data show that endogenous SPPL2a - in agreement with overexpression studies - is localised in membranes of lysosomes/late endosomes."
16676,16680c22451,22457
< "P35377-1","RefSeq","NP_001239494.1","26294734","Nociceptin opioid receptor agonists are promising drugs for treating pain in sickle cell anemia."
< "P35377-1","RefSeq","NP_001239494.1","26290245","These knock-in mice have NOP receptors that function both in vitro and in vivo and have provided a detailed characterization of NOP receptors in brain, spinal cord, and DRG neurons."
< "Q9WU00-1","RefSeq","NP_001157698.1","30333037","That Nrf1 and Nrf1-mediated pathways have context-dependent and cell-state-specific functions during neural development Publication Status: Online-Only"
< "Q9WU00-1","RefSeq","NP_001157698.1","30261697","MRNA and protein levels of Nrf1D were detected to varying extents in hemopoietic and somatic tissues.  Nrf1D-derived isoforms were present in blood plasma. Publication Status: Online-Only"
< "Q9WU00-1","RefSeq","NP_001157698.1","29625129","These findings identified a negative feedback loop between miR-378 and Nrf1 that promotes the pathogenesis of hepatosteatosis"
---
> "Q8BVP5-1","RefSeq","NP_598763.1","15077195","CKI-gamma2 could further potentiate the ER corepressive function of MTA1s. Kinase dead CK1-gamma2 could not repress estrogen-induced ER transactivation functions."
> "Q3UHN9-1","RefSeq","NP_032332.2","29688404","An essential role for Heparin sulfate proteoglycan sulfation via NDST1,2,3 in modulating signal transduction during mouse implantation."
> "Q3UHN9-1","RefSeq","NP_032332.2","29330473","Tubulo-interstitial macrophage influx and fibrosis are reduced by endothelial Ndst1 deficiency in experimental diabetes."
> "Q7TNE6-1","RefSeq","NP_899245.1","20063414","Duxbl proteins play regulatory roles during myogenesis and reproductive developments"
> "Q7TNE6-1","RefSeq","NP_899245.1","17911620","Involved in thymocyte development. Knockdown by shRNA impaired CD4/8 double-negative thymocyte differentiation. Overexpression impaired TCR-beta expression and CD4/8 double-positive thymocyte production. Expressed also in B-lymphocytes."
> "Q8C0D4-1","RefSeq","NP_083553.2","18504429","ARHGAP12 inactivates RAC1, thereby impairing cell motility, invasion and adhesion to the extracellular matrix. The gene is transcriptionally suppressed by Hepatocyte Growth Factor in human and murine cell lines."
> "Q8C0D4-1","RefSeq","NP_083553.2","18241859","Immunofluorescence staining and confocal laser-scanning microscopy demonstrated that Arhgap12 localizes at epithelial cell-cell adherent junctions in various mouse tissues."
16689a22467,22468
> "P63137-1","RefSeq","NP_032096.1","30013074","These extensive schizophrenia-like and comorbid phenotypes brought about by Gabrb2 knockout, in conjunction with our previous findings on GABRB2 association with schizophrenia, support a pivotal role of GABRB2 in schizophrenia etiology. Publication Status: Online-Only"
> "P63137-1","RefSeq","NP_032096.1","29706582","In inhibitory transmission onto hippocampal CA1 pyramidal cells, deletion of all beta subunits 1, 2, and 3 completely eliminated inhibitory responses. In addition, only knockout of beta3, alone or in combination with another beta subunit, impaired inhibitory synaptic transmission. expression of beta3 alone on the background of the beta1-3 subunit knockout was sufficient to restore synaptic and extrasynaptic inhibitory ..."
16694a22474,22475
> "P97467-1","RefSeq","NP_038654.2","29540787","Results find that PAM colocalizes with actin but not microvilli in polarized multi-ciliated tracheal epithelial cells. Publication Status: Online-Only"
> "P97467-1","RefSeq","NP_038654.2","26296884","Oxygen Sensitivity of the Peptidylglycine alpha-Amidating Monooxygenase (PAM) in Neuroendocrine Cells"
16699a22481,22485
> "O88998-1","RefSeq","NP_001033703.1","27787612","The OLFM1 is a newly identified interphotoreceptor matrix (IPM) molecule that serves an important role for photoreceptor homeostasis, which is significantly compromised in the eyes of Olfm1 mutant mice."
> "O88998-1","RefSeq","NP_001033703.1","26107991","Defective fertility in Olfm1(-/-) females is most likely a secondary effect of defective olfaction."
> "O88998-1","RefSeq","NP_001033703.1","24095980","Olfm1 is a multifunctional protein that may play important roles not only in differentiation and proliferation of neuronal precursor cells and axon growth but also in behavior, olfactory activity and numerous functions associated with Ca2 + signaling"
> "O88998-1","RefSeq","NP_001033703.1","12385760","Study of noelin expression during mouse development"
> "P80314-1","RefSeq","NP_031662.2","22144988","Role of chaperonin-containing t-complex polypeptide 1 beta (CCT2) in the regulation of mesangial cell contraction, proliferation, and migration with filamentous/globular-(F/G-) actin ratio under high glucose induction"
16707a22494,22497
> "Q9QYE0-1","RefSeq","NP_064353.2","31059011","LncRNAs and mRNAs were differentially expressed in pleomorphic adenoma tissues obtained from PLAG1 transgenic mice as compared with those from control mice. These differentially expressed lncRNAs may act as novel biomarkers and therapeutic targets for pleomorphic adenoma."
> "Q9QYE0-1","RefSeq","NP_064353.2","30048678","PLAG1 deficiency does not have a major impact on the reproductive control by the hypothalamo-pituitary system."
> "Q9QYE0-1","RefSeq","NP_064353.2","28706261","Loss of PLAG1 resulted in significantly lowered daily sperm production, in reduced sperm motility, and in several animals, in sloughing of the germinal epithelium. The results demonstrate that the subfertility seen in male PLAG1-deficient mice is, at least in part, the result of significantly reduced sperm output and sperm motility. Publication Status: Online-Only"
> "Q9QYE0-1","RefSeq","NP_064353.2","15606491","Plag1 disruption in mouse differentially affects pre- and postnatal growth and development of organs, with reproductive repercussions"
16717a22508,22510
> "P46412-1","RefSeq","NP_032187.2","29244159","GPx3 deficiency is a substantive contributing factor to the development of kidney disease-induced cardiac disease."
> "P46412-1","RefSeq","NP_032187.2","28677736","These results suggest that GPx3 is an important factor for inhibition of Acetaminopheninduced hepatotoxicity both in vivo and in vitro."
> "P46412-1","RefSeq","NP_032187.2","27918237","GPX3 promoter methylation predicts colorectal carcinoma sensitivity to platinum."
16720a22514
> "Q3U4H6-1","RefSeq","NP_001139545.1","21807949","Lipid-droplet-targeted isoform is a key regulator of the proteasome"
16728,16732c22522,22523
< "Q7JJ13-1","RefSeq","NP_001191902.1","28388437","BRD2 acts to augment the boundary function of CTCF both by limiting the spread or range of enhancer activity and by physically preventing the formation of cross-boundary contacts genome-wide."
< "Q7JJ13-1","RefSeq","NP_001191902.1","28262505","Brd2 and Brd4 genetic transcription required for Th17 cell development and adaptive immunity."
< "Q7JJ13-1","RefSeq","NP_001191902.1","27865874","These results provided evidence for a novel role of Brd2 in chronic inflammation and insulin resistance."
< "Q7JJ13-1","RefSeq","NP_001191902.1","26804911","This study reveals an antagonistic relationship between H2A.Z.1ub and BRD2 to regulate the transcriptional balance at bivalent genes to enable proper execution of developmental programs."
< "Q7JJ13-1","RefSeq","NP_001191902.1","9528865","Brd2 autophosphorylation activity is induced in mouse tissues (lung, kidney, brain, liver and heart) upon systemic treatment with the mitogens Epidermal Growth Factor or Phorbol 12-Myristate 13-Acetate."
---
> "Q7SIG6-1","RefSeq","NP_001128664.1","28322786","In conclusion, we have identified that ARL15 acts as an insulin-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1/PDPK1/AKT insulin pathway by interacting with its GAP ASAP2 and activating PDPK1. This research may provide new insights into GTPase-mediated insulin signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin sensitizati"
> "Q7SIG6-1","RefSeq","NP_001128664.1","27601625","These findings identify ASAP2 as a new target of Selk-dependent palmitoylation and reveal a new mechanism regulating the efficiency of FcgammaR-mediated phagocytosis."
16742a22534,22537
> "A2AQ25-1","RefSeq","NP_835160.2","26678520","Study deleted 868 kb of genomic DNA encompassing nearly the whole coding region of Skt/Etl4. Surprisingly, mice homozygous for this deletion were viable and fertile. Despite expression of Skt/Etl4 in multiple tissues during embryonic development the deletion caused only mild malformations of the axial skeleton. Publication Status: Online-Only"
> "Q64008-1","RefSeq","NP_258436.2","29290584","Loss-of-function mutations in the Rab34 gene lead to defects in the assembly of primary cilia, in the trafficking of proteins to primary cilia and, consequently, to impaired reception of signals from the Hedgehog pathway. Erratum:[Dev Cell. 2018 Jan 22;44(2):271. PMID: 29401421]"
> "Q64008-1","RefSeq","NP_258436.2","29991022","CSN6 and Rab34 are involved in AR trafficking by regulating the phosphorylation signaling pathway. These findings provide new insights into the testosterone signaling pathway in Sertoli cells that mediates spermatogenesis."
> "Q64008-1","RefSeq","NP_258436.2","12446704","Association with membrane ruffles and macropinosomes and promotes macropinosome formation"
16745a22541
> "Q8BHS6-1","RefSeq","NP_082146.2","19304657","Sox10 is a membrane-associated factor whose transcriptional function is increased by direct interactions with ARMCX3"
16752a22549,22555
> "Q8K4F0-1","RefSeq","NP_848802.2","30738249","CD226 is involved in megakaryocyte activation and early-stage differentiation."
> "Q8K4F0-1","RefSeq","NP_848802.2","30808363","This study clarifies how DNAM-1 modifies the bidirectional crosstalk of natural killer cells with CD155(+) dendritic cells, which can be exploited to suppress CNS autoimmunity and strengthen tumor surveillance Publication Status: Online-Only"
> "Q8K4F0-1","RefSeq","NP_848802.2","30591568","The hybrid complex structure of CD226-ecto binding to the first domain of CD155 (hCD155-D1) reveals a conserved binding interface with the first domain of CD226 (D1), whereas the second domain of CD226 (D2) both provides structural supports for the unique architecture of CD226 and forms direct interactions with CD155."
> "Q8K4F0-1","RefSeq","NP_848802.2","30504141","CD226 regulation of NK cell cytotoxicity is facilitated through inactivation of FOXO1. Gene-expression analysis of NK cells isolated from syngeneic tumors grown in wild-type or CD226-deficient mice revealed dysregulated expression of FOXO1-regulated genes in the absence of CD226."
> "Q8K4F0-1","RefSeq","NP_848802.2","16249389","DNAM-1 ligands stimulate innate immunity by in dendritic and natural killer cells, which efficiently prime cell-mediated tumor-specific immunity."
> "Q8K4F0-1","RefSeq","NP_848802.2","16034094","CD226 is a costimulatory molecule that plays an important role in activation and effector functions of T helper type 1 (Th1) cells."
> "Q8K4F0-1","RefSeq","NP_848802.2","15752754","We demonstrated that ligand binding of murine DNAM-1 induced a costimulatory signal in antigen-specific CD8+ T cells."
16756a22560,22565
> "Q3UQI9-1","RefSeq","NP_808551.2","17971504","C330043M08Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
> "Q8VEE4-1","RefSeq","NP_080929.1","30716097","Using an inducible germline-specific inactivation strategy, we find that loss of RPA completely abrogates loading of RAD51/DMC1 recombinases to programmed meiotic DNA double strand breaks, thus blocking strand invasion required for chromosome pairing and synapsis. Publication Status: Online-Only"
> "Q8VEE4-1","RefSeq","NP_080929.1","30154456","Localization of the replication protein A (RPA) complex on the chromosome axes meiotic prophase in mouse spermatocytes, is reported. Publication Status: Online-Only"
> "Q8VEE4-1","RefSeq","NP_080929.1","28173122","The recovery of abnormal phenotypes of mutant Ataxin-1 knock-in (Atxn1-KI) mice in the dendrite and spine morphology of Purkinje cells by AAV vector-mediated expression of RpA1 was reported."
> "P70314-1","RefSeq","NP_035227.1","30262816","Pitx1 is controlled by an enhancer (Pen) that shows activity in forelimbs and hindlimbs. Forelimbs and hindlimbs have fundamentally different chromatin configurations, whereby Pen and Pitx1 interact in hindlimbs and are physically separated in forelimbs. Structural variants can convert the inactive into the active conformation, thereby inducing Pitx1 misexpression in forelimbs."
> "P70314-1","RefSeq","NP_035227.1","29549111","Pitx1 distal enhancer loss have only mild effects on Pitx1 expression in the hindlimb and no overt effects on hindlimb or mandibular morphology. Publication Status: Online-Only"
16772a22582
> "Q91YM4-1","RefSeq","NP_598772.1","18255060","Tight regulation of WAP gene expression parallels variations in the chromatin structure and DNA methylation profile throughout the Ramp3-WAP-Tbrg4 locus."
16775a22586,22588
> "Q9R0Q4-1","RefSeq","NP_062742.4","15923606","Data show that MRGX is ubiquitously expressed in all tissues of adult mice and also during embryogenesis, and overlaps with its homolog Mrg15."
> "O08665-1","RefSeq","NP_033178.2","30627913","It can be assumed that Sema3a synthesized in the thymus stroma can act as a functional antagonist of HGF and KGF and have an inhibitory effect when these growth factors are administered into the body for the therapeutic purpose of restoring thymus functions."
> "O08665-1","RefSeq","NP_033178.2","30579864","Data found that Sema3A was significantly downregulated in vascular smooth muscle cells (VSMCs) during neointimal hyperplasia after vascular injury in mice and in human atherosclerotic plaques. Its overexpression inhibited VSMC proliferation and migration, as well as increasing differentiated gene expression."
16778a22592,22593
> "P63013-1","RefSeq","NP_783617.2","28366454","Postnatal PRX1-expressing stem cells of the calvaria are required for bone regeneration."
> "O88346-1","RefSeq","NP_035748.1","29931346","Similar functional and histological phenotypes were observed in other human cohorts and two transgenic murine models (Tnnt1-/- and Tnnt1 c.505G>T). These findings have implications for emerging molecular therapies, including the suitably of TNNT1 gene replacement for newborns with 'Amish' nemaline myopathy or other TNNT1-associated myopathies."
16788a22604,22606
> "Q4VBD9-1","RefSeq","NP_083262.1","19429458","Progesterone receptors and glucocorticoid receptors, but not estrogen receptors, up-regulate transcription from the GDNF-inducible zinc finger protein promoter"
> "Q4VBD9-1","RefSeq","NP_083262.1","14522971","Induction of GZF1 expression via the is required for renal branching morphogenesis Erratum:[J Biol Chem. 2004 Jan 23;279(4):3120]"
> "Q8BSI6-1","RefSeq","NP_001288581.1","22927429","Ribosome profiling indicates that this gene can use a non-AUG (CUG) start codon in both human HEK293 and mouse embryonic fibroblast cells."
16799a22618
> "Q60991-1","RefSeq","NP_031851.3","30728500","Results indicate that osteoarthritis is a disease associated with metabolic disorders and suggest that targeting the CH25H-CYP7B1-RORalpha axis of cholesterol metabolism may provide a therapeutic avenue for treating osteoarthritis."
16815a22635,22637
> "Q9JHL1-1","RefSeq","NP_075938.2","28882822","NHERF2 and NHERF3 have overlapping roles in NHE3 stimulation by LPA and inhibition by elevated Ca(2+) and cGMP."
> "Q9JHL1-1","RefSeq","NP_075938.2","28893864","LRBA deficiency is associated with a reduced abundance of radixin and Nherf2, two adaptor proteins, which are important for the mechanical stability of the basal taper region of stereocilia."
> "Q9JHL1-1","RefSeq","NP_075938.2","15665527","Demonstration of the significance of SGK1 and NHERF2 as TRPV5 modulators which are likely to participate in the regulation of calcium homeostasis by 1,25(OH)2D3"
16825,16830c22647,22652
< "P28659-1","RefSeq","NP_001231820.1","30158053","These results indicate that CELF1 target RNAs are aberrantly spliced in the Type 1 diabetic heart leading to abnormal gene expression."
< "P28659-1","RefSeq","NP_001231820.1","28874395","Increased CELF1 expression down-regulates Cx43 mRNA level in the dilated cardiomyopathy heart."
< "P28659-1","RefSeq","NP_001231820.1","28763438","LncBATE10 can decoy Celf1 from Pgc1alpha, thereby protecting Pgc1alpha mRNA from repression by Celf1 Publication Status: Online-Only"
< "Q91Z31-1","RefSeq","NP_001297640.1","30733148","Axonogenesis-associated splicing changes are governed by PTBP2."
< "Q91Z31-1","RefSeq","NP_001297640.1","29045475","Ptbp2 is an essential factor in heat stress-induced sperm cell injury and non-obstructive azoospermia. Publication Status: Online-Only"
< "Q91Z31-1","RefSeq","NP_001297640.1","10829067","PTBP2 was identified as a brain-expressed protein that interacts with the paraneoplastic target antigen Nova1 by yeast 2-hybrid, in vivo co-IP and co-localization in neurons. Functionally, the proteins antagonize each other in splicing assays."
---
> "Q64437-1","RefSeq","NP_033756.2","24668648","ADH3 promotes liver fibrosis by enhancing hepatic stellate cell activation and inhibiting natural killer cell activity"
> "Q64437-1","RefSeq","NP_033756.2","17257171","Cellular expression of Adh3 in the GUI tract was studied."
> "Q9WTP3-1","RefSeq","NP_038919.1","29579396","That Spdef regulates baseline Muc5b expression in respiratory epithelia but does not contribute to Muc5b regulation in a mouse model of Muc5b-predominant mucus obstruction caused by airway dehydration"
> "Q9WTP3-1","RefSeq","NP_038919.1","29477409","A novel mechanism that contributes to the EMT and metastatic phenotype observed in a subset of ADT-resistant prostate cancer, where the CCL2 is stimulated through the inactivated of AR-mediated SPDEF."
> "Q9WTP3-1","RefSeq","NP_038919.1","28390865","In studies of mice and human CRC, we found that SPDEF induces a quiescent state in CRC cells by disrupting binding of b-catenin to TCF1 and TCF3 and regulation of genes that control the cell cycle."
> "Q9WTP3-1","RefSeq","NP_038919.1","17347682","SPDEF was induced following intratracheal allergen exposure and after Th2 cytokine stimulation and was sufficient to cause goblet cell differentiation of Clara cells in vivo."
16834a22657,22658
> "Q91X97-1","RefSeq","NP_598855.2","17548529","According to their distribution in the olfactory bulb, neurocalcin-immunoreactive interneurons could reflect a sexually dimorphic regulation of specific odorants."
> "Q91X97-1","RefSeq","NP_598855.2","16101019","Neurocalcin-containing DRG neurons include all proprioceptive, and a subset of mechanoreceptive and proprioceptive. Furthermore, NT-3 is involved in the maturation of motor end-plates."
16836a22661
> "P70408-1","RefSeq","NP_033995.1","16181616","This demonstration of a distinctive expression pattern of cadherin-10 suggests that it has a pivotal role in the development and maintenance of brain barriers."
16839a22665,22670
> "Q9CWT3-1","RefSeq","NP_082311.3","29452206","Deficiency of sorting nexin (SNX) 10 increases the stability of LAMP-2A by inhibiting cathepsin A maturation, resulting in the increase of CMA activity and, thus, alleviates alcohol-induced liver injury and steatosis."
> "Q9CWT3-1","RefSeq","NP_082311.3","28498635","Results first identified the role of SNX10 in MMP9 trafficking and secretion, and provided an evidence for SNX10 as a possible therapeutic target for bone destructing disease."
> "Q9CWT3-1","RefSeq","NP_082311.3","26141367","SNX10 plays an important role in the bone destruction of collagen-induced arthritis mice."
> "Q9CWT3-1","RefSeq","NP_082311.3","26856241","Data disclose a crucial role and novel function for SNX10 in macrophage polarization. Loss of SNX10 function may be a potential promising therapeutic strategy for IBD. Publication Status: Online-Only"
> "Q9CWT3-1","RefSeq","NP_082311.3","25811986","Supplementation with calcium gluconate rescued mice from the rachitic phenotype and extended life span in global Snx10-deficient mice, suggesting that this may be a life-saving component of the clinical approach to Snx10-dependent human osteopetrosis Publication Status: Online-Only"
> "Q9CWT3-1","RefSeq","NP_082311.3","22174188","Immunohistochemical analysis of embryo sections showed expression in long bone, calvariae, and developing teeth. The expression was limited to cells that also expressed TRAP, demonstrating osteoclastic localization."
16849a22681,22683
> "P51450-1","RefSeq","NP_035411.2","30567733","These data suggest that SRC3 works with SRC1 to regulate RORgammat-dependent Th17 differentiation but is not essential for RORgammat-dependent thymocyte development."
> "P51450-1","RefSeq","NP_035411.2","30455347","RORgamma inverse agonists reduced mortality in an LPS/d-galactosamine-induced fulminant hepatitis mouse model. These results illustrate a major role for RORgamma in regulation of innate immunity via modulation of NLRP3 inflammasome activity."
> "P51450-1","RefSeq","NP_035411.2","30451821","Sumoylation of RORgammaT regulates TH17 differentiation and thymocyte development via histone acetyltransferase KAT2A, which stabilizes the binding of SRC1 to enhance RORgammaT transcription factor activity. Publication Status: Online-Only"
16852a22687,22690
> "Q9QZM3-1","RefSeq","NP_064336.1","26198769","Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders. Review article"
> "Q9QZM3-1","RefSeq","NP_064336.1","14605001","Neurotrophin-1/B-cell stimulating factor 3(NNT-1/BSF-3) is expressed in pituitary folliculostellate TtT/GF cells and induced by PKC-, PKA-, and ERK1/2-dependent mechanisms"
> "Q9QZM3-1","RefSeq","NP_064336.1","12090754","CLC plays a role in astrocyte differentiation via STAT3 activation within the developing brain"
> "Q9JHH2-1","RefSeq","NP_064682.1","29178985","Study demonstrates a complementary role between TSSC6 and P2Y12 receptor in platelets in regulating 'outside in' integrin alphaIIbbeta3 signalling thrombus growth and stability."
16855a22694,22700
> "Q9WVJ9-1","RefSeq","NP_067449.3","29931197","In fibulin-4 mutant mice, altered mitochondrial function and metabolic dysregulation, leading to increased ROS levels and altered energy production, may contribute to thoracic aortic aneurysm formation via PGC1A regulation."
> "Q9WVJ9-1","RefSeq","NP_067449.3","27585882","These data clearly establish a functional link between Ltbp-4L and fibulin-4 as a crucial molecular requirement for survival and elastogenesis in mice."
> "Q9WVJ9-1","RefSeq","NP_067449.3","26711913","Fibulin-4 seems to play a role in regulating tendon collagen fibrillogenesis, in addition to its essential function in elastogenesis."
> "Q9WVJ9-1","RefSeq","NP_067449.3","16478991","Fibulin-4 plays an irreplaceable role in elastogenesis."
> "Q9JI48-1","RefSeq","NP_631937.1","26669866","Results establish PLAC8 as a central mediator of tumor progression in PDAC."
> "Q9JI48-1","RefSeq","NP_631937.1","24794439","Plac8 provides a mechanistic link between primary oncogenic mutations and the induction of autophagy, a central mechanism of metabolic reprogramming, during PDA progression."
> "Q9JI48-1","RefSeq","NP_631937.1","23155406","Plac8 is an upstream regulator of C/EBPbeta required for adipogenesis in vitro. In vivo, Plac8 is dispensable for the differentiation of white adipocytes with preserved fat storage capacity but is required for normal fat cell count regulation"
16867,16873d22711
< "B2RXV4-1","RefSeq","NP_001074728.1","27006955","Study found that primary and immortalized murine macrophages downregulate Flvcr mRNA levels upon LPS stimulation; findings point to a new role for FLVCR and heme export in macrophages responses to infection and inflammation"
< "B2RXV4-1","RefSeq","NP_001074728.1","26067085","Data shows that FLVCR1a participates in the control of intestinal mucosa homeostasis by exporting the excess of de novo synthesized heme from intestinal cells."
< "B2RXV4-1","RefSeq","NP_001074728.1","25582857","These studies identify a novel and unexpected role for FLVCR, a major facilitator superfamily metabolite transporter, in T cell development"
< "B2RXV4-1","RefSeq","NP_001074728.1","24486949","Flvcr1a maintains a free heme pool that regulates heme synthesis and degradation as well as cytochromes P450 expression and activity."
< "B2RXV4-1","RefSeq","NP_001074728.1","24021674","FLVCR is redundant in stem cells but has critical and contrasting stage-specific roles in discrete hematopoietic lineages"
< "B2RXV4-1","RefSeq","NP_001074728.1","22058337","Hemochromatosis is associated not only with excessive accumulation of free iron in the retina and retinal pigment epithelium but also with excessive accumulation of heme. Publication Status: Online-Only"
< "B2RXV4-1","RefSeq","NP_001074728.1","18258918","Data show that FLVCR exports heme & is required by erythroid progenitors to complete terminal differentiation; data show that FLVCR functions in macrophage heme-iron recycling and that systemic iron balance involves heme-iron trafficking via FLVCR"
16885a22724,22725
> "Q0VF58-1","RefSeq","NP_031759.2","28090790","The results of this study suggested a mechanism by which the loss of collagen XIX speeds Perineuronal Nets degradation in Telencephalon degradation."
> "Q0VF58-1","RefSeq","NP_031759.2","15302855","Collagen XIX has a role in esophageal muscle development and function"
16892a22733,22736
> "P70174-1","RefSeq","NP_032311.2","30942635","Effects of histamine H1 type receptor (H1R) in regulating osteoblastic cell differentiation and mineralization"
> "P70174-1","RefSeq","NP_032311.2","28722302","Data (including data from studies in knockout mice) suggest that sleep-promoting effect of dietary supplement rice bran is dependent on Hrh1 antagonism; rice bran fully inhibits Hrh1 agonist-induced increase in action potential frequency in tuberomammillary nucleus neurons."
> "P70174-1","RefSeq","NP_032311.2","27035718","This study shows that the histamine 1 receptor might be useful therapeutic target for treatment of metal allergy"
> "Q9JMD0-1","RefSeq","NP_035881.1","27177335","Data show that Zfp207 binds to Bub3 to form a complex and maintains its protein level in oocytes, and that overexpression of Bub3 is able to partially rescue the occurrence of aneuploid eggs in Zfp207-depleted oocytes."
16897a22742,22745
> "Q9R1M5-1","RefSeq","NP_035990.1","24374158","MATER is required for endoplasmic reticulum distribution and Ca2+ homeostasis in oocytes, likely due to defects in lattice-mediated ER positioning and/or redistribution."
> "Q9R1M5-1","RefSeq","NP_035990.1","22357545","It was concluded that lack of Nlrp5 in oocytes triggers premature activation of the mitochondrial pool, causing mitochondrial damage that cannot be rescued by inactivation of Bax. Publication Status: Online-Only"
> "Q9R1M5-1","RefSeq","NP_035990.1","21447630","Transgenic expression of MATER induces antigen-specific tolerance with a significant reduction in ovarian autoimmunity."
> "Q9R1M5-1","RefSeq","NP_035990.1","18804437","Results describe a subcortical maternal complex, containing Mater, Floped, TLE6, and Filia, that is essential for preimplantation mouse embryogenesis."
16910a22759,22764
> "O35632-1","RefSeq","NP_034619.2","28765635","Knockdown of Hyal2 in articular cartilage induced osteoarthritis development and progression possibly mediated by an imbalance of hyaluronan metabolism. Publication Status: Online-Only"
> "O35632-1","RefSeq","NP_034619.2","28081210","Hyal2-/- mice present craniofacial abnormalities, including submucosal cleft palate and incompletely penetrant cor triatriatum sinister with hearing loss. Publication Status: Online-Only"
> "O35632-1","RefSeq","NP_034619.2","28196902","Hyal2(-/-) mice have increased hyaluronan, which may promote endothelial-to-mesenchymal transition and proliferation of mesenchymal cells leading to congenital heart defects and heart failure."
> "O35632-1","RefSeq","NP_034619.2","27398974","Our data uncover a previously unsuspected mechanism of how hyaluronan and Hyal-2 control platelet generation."
> "O35632-1","RefSeq","NP_034619.2","11960552","Hyal-2 enhancement of tumor necrosis factor-alpha-stimulated cytotoxicity in fibroblasts is blocked by Transforming growth factor-beta1. Publication Status: Online-Only"
> "Q9CWW6-1","RefSeq","NP_081457.1","23720771","Data indicate the association of Par14 with insulin receptor substrate 1 (IRS-1) in human HepG2 cells overexpressing both as well as endogenously in the mouse liver."
16915a22770,22775
> "Q61122-1","RefSeq","NP_032693.2","23935197","These data suggest that type I IFN stimulation induces a rapid recruitment of a repressive Egr3/Nab1 complex that silences transcription from the ifngr1 promoter."
> "Q80WJ1-1","RefSeq","NP_874355.1","23451117","Results suggest that GGN plays a role in male meiotic DSB repair and is absolutely required for the survival of pre-implantation embryos."
> "Q8BHE1-1","RefSeq","NP_666350.2","17023415","Gemin8 has an essential role in the proper structural organization of the SMN complex and the involvement of the heteromeric subunit containing Gemin6, Gemin7, Gemin8, and Unrip in the recruitment of Sm proteins to the snRNP assembly pathway"
> "Q8BHE1-1","RefSeq","NP_666350.2","16434402","Gemin8 is a novel integral component of the SMN complex"
> "P70380-1","RefSeq","NP_032386.1","31017261","Pretreatment of the mice with IL18 increased body weight, augmented colon length, reduced inflammatory infiltration, promoted mucin (Muc)2 expression, increased the function and quantity of goblet cells and increased the mRNA levels of resistinlike molecule (RELM) beta and trefoil factor family (TFF) 3 in mice with DSSinduced colitis, through the IL22/STAT3 pathway."
> "P70380-1","RefSeq","NP_032386.1","30870716","We report for the first time that IL-18 promoted the lung fibroblast senescence and the senescence-associated secretory phenotype in pulmonary fibrosis through blocking Klotho pathway"
16919a22780,22784
> "O55060-1","RefSeq","NP_058065.2","28406961","With the significant mitigation of TPMT wild type-expressing cells to cisplatin cytotoxicity, findings demonstrate a drug-gene interaction between increased TPMT activity and decreased susceptibility to cisplatin-induced toxicity of inner ear cells. Publication Status: Online-Only"
> "O55060-1","RefSeq","NP_058065.2","24710003","These findings support the notion that germline polymorphisms in Tpmt affect not only host tissue toxicity but also antitumor effectiveness."
> "O55060-1","RefSeq","NP_058065.2","15083069","Suggestion that differential mouse TPMT activity is due to variation in mRNA expression"
> "B2RRD7-1","RefSeq","NP_001269056.1","27500495","BRPF1 has a role in development of fetal hematopoietic stem cells"
> "B2RRD7-1","RefSeq","NP_001269056.1","25773539","A crucial role of Brpf1 in controlling mouse embryo development and regulating cellular and gene expression programs"
16924,16925d22788
< "Q07563-1","RefSeq","NP_001277754.1","28693719","Here, the authors show that COL17 plays a central role in regulating interfollicular epidermis (IFE) proliferation. Loss of COL17 leads to transient IFE hypertrophy in neonatal mice owing to aberrant Wnt signaling. Publication Status: Online-Only"
< "Q9D0Z3-1","RefSeq","NP_081113.1","17971504","Tmem53 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
16926a22790,22792
> "Q9WTX5-1","RefSeq","NP_035673.3","27732853","Consistent with Skp1a functioning through regulation of Nmnat2, Skp1a knockdown fails to protect axons from Nmnat2 knockdown."
> "Q9WTX5-1","RefSeq","NP_035673.3","27063938","Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response. Publication Status: Online-Only"
> "Q9WTX5-1","RefSeq","NP_035673.3","24085301","Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex."
16931a22798,22801
> "Q8CAE3-1","RefSeq","NP_112446.2","29644895","Compromised PASMC beta1 function may contribute to the heightened microvascular vasoconstriction that characterizes pulmonary hypertension."
> "Q8CAE3-1","RefSeq","NP_112446.2","29486465","Whole-cell currents density of BK channels and amplitude of spontaneous transient outward currents were significantly reduced in hypoxia vascular myocytes."
> "Q8CAE3-1","RefSeq","NP_112446.2","28429615","Expression of vascular large-conductance calcium-activated potassium channel Kcnmb1 is regulated by Nrf2 signaling."
> "Q8CAE3-1","RefSeq","NP_112446.2","28487419","Study showed that in human and rat arterial myocytes, membrane depolarization rapidly increased the cell surface abundance of auxiliary BK beta1 subunits but not that of the pore-forming BKalpha channels. Membrane depolarization stimulated voltage-dependent Ca(2+) channels, leading to Ca(2+) influx and the activation of Rho kinase (ROCK) 1 and 2. Publication Status: Online-Only"
16943a22814
> "Q3TZM9-1","RefSeq","NP_898965.1","25036826","Hence, we concluded that there is different transcriptional control mechanism between mALG11 and hALG11"
16944a22816,22818
> "A2APC3-1","RefSeq","NP_083340.2","27257088","Ttll9 plays essential roles in maintaining the normal structure and beating pattern of sperm flagella by establishing normal heterogeneous polyglutamylation patterns."
> "E9PV66-1","RefSeq","NP_083177.2","18761673","Myo18B is a unique unconventional myosin that is predominantly expressed in myocytes and whose expression is essential for the development and/or maintenance of myofibrillar structure."
> "E9PV66-1","RefSeq","NP_083177.2","17386922","Expression of HOMER2 enhanced the ability of MYO18B to suppress anchorage-independent growth. These results indicate that HOMER2 and MYO18B cooperate together in tumor suppression."
16948a22823,22826
> "Q8VBV9-1","RefSeq","NP_570936.1","27280498","Transgenic mice overexpressing PSGR in the prostate were reported to develop an acute inflammatory response followed by emergence of low grade prostatic intraepithelial neoplasia, whereas mice with compound PSGR overexpression and loss of PTEN exhibited accelerated formation of invasive prostate adenocarcinoma. (Review) Review article"
> "Q8VBV9-1","RefSeq","NP_570936.1","26560302","In addition to its role in olfaction, Olfr78 acts as a hypoxia sensor in the breathing circuit by sensing lactate produced when oxygen levels decline"
> "Q8VBV9-1","RefSeq","NP_570936.1","25813788","Olfr78 is involved in the regulation of hormone secretion from such cells, as evoked by nutritional compounds"
> "Q8VBV9-1","RefSeq","NP_570936.1","23401498","SCFAs produced by the gut microbiota modulate blood pressure via Olfr78 and Gpr41."
16951a22830,22833
> "P70121-1","RefSeq","NP_033598.2","17056598","ZHX proteins 1, 2 and 3 are major transcriptional mediators of podocyte disease Erratum:[J Biol Chem. 2007 Apr 27;282(17):13140]"
> "Q9WVM1-1","RefSeq","NP_036155.1","24355749","Deletion of MgcRacGAP in the male germ cells impairs spermatogenesis and causes male sterility in the mouse."
> "Q9WVM1-1","RefSeq","NP_036155.1","23997213","TLR4 signaling shapes B cell dynamics via MyD88-dependent pathways and Rac GTPases."
> "Q9WVM1-1","RefSeq","NP_036155.1","23696789","APC(CDH1) targets MgcRacGAP for destruction in the late M phase. Erratum:[PLoS One. 2014;9(3):e89706] Publication Status: Online-Only"
16957a22840,22846
> "P97302-1","RefSeq","NP_031546.1","31194955","Bach1 inhibition alleviates oxidative-stress-induced osteoblast apoptosis and dysfunction by enhancing Nrf2/ARE signaling activation, findings that suggest a critical role for the Bach1/Nrf2/ARE regulation axis in osteoporosis progression."
> "P97302-1","RefSeq","NP_031546.1","30937482","Heme binding to the intrinsically disordered region of Bach1"
> "P97302-1","RefSeq","NP_031546.1","30853683","Disordered-ordered transition such as 'coupled folding and binding' is not involved in the Bach1-heme system."
> "P97302-1","RefSeq","NP_031546.1","30535483","Decreasing malondialdehyde levels via nuclear factor (erythroidderived 2)like 2 protein/BTB and CNC homology 1 mediated antioxidant effect."
> "P97302-1","RefSeq","NP_031546.1","11387216","Bach1 is a heme-binding transcription factor. DNA binding activity of Bach1 is inhibited by heme."
> "P97302-1","RefSeq","NP_031546.1","10620011","Bach1 forms a multivalent DNA binding complex and functions as an architectural transcription factor."
> "P97302-1","RefSeq","NP_031546.1","9565602","Bach1 generates multivalent DNA binding complex through protein-protein interaction mediated by its BTB/POZ domain"
16963a22853
> "Q8VGZ7-1","RefSeq","NP_667304.1","25635859","Three olfactory receptors (olfr544, olfr558, and olfr1386) were expressed in the olfactory marker protein (+) cells of the bladder and thyroid. Publication Status: Online-Only"
16975,16977c22865
< "Q2M3X8-1","RefSeq","NP_001289564.1","28803787","That Phactr1 takes part in neuronal functions regulated in a spatiotemporal manner"
< "Q2M3X8-1","RefSeq","NP_001289564.1","28720499","It has been demonstrated that PHACTR1 gene expression increases with the progression of vascular calcification and that regulation of PHACTR1 in smooth muscle cells modulates the severity of vascular calcification."
< "Q2M3X8-1","RefSeq","NP_001289564.1","22766235","This study demonistrated that Phactr1 appeared to be expressed in post-mitotic neurons in developmental brain."
---
> "Q00724-1","RefSeq","NP_035385.1","30126844","Also during a high-fat diet challenge, elevated levels of RBP4 in the circulation failed to aggravate the worsening of systemic parameters of glucose and energy homeostasis. These findings show that liver-secreted RBP4 does not impair glucose homeostasis. We conclude that a modest increase of its circulating levels in mice, as observed in the obese, insulin-resistant state, is unlikely to be a causative factor for impaire"
16978a22867,22869
> "Q8BUL6-1","RefSeq","NP_598703.1","27859053","This study shows that TAPP1/2 double knock-out mice develop chronic germinal centers with age and show abnormal expression of B-cell activation anddevelop lupus-like characteristics including anti-DNA antibodies and deposition of immune complexes in kidneys"
> "Q8BUL6-1","RefSeq","NP_598703.1","26242484","Results identify TAPP1 as an important negative regulator of oligodendrocyte precursor cells differentiation through the Mek/Erk signaling pathway."
> "Q8BUL6-1","RefSeq","NP_598703.1","22777911","Interacts with phosphatidylinositol (3,4)-bisphosphate thus regulating B-cell activation and autoantibody production"
16986a22878,22890
> "P98200-1","RefSeq","NP_056618.1","24413176","ATP8A2 plays a crucial role in photoreceptor and spiral ganglion cell function and survival by maintaining phospholipid composition and contributing to vesicle trafficking."
> "P98200-1","RefSeq","NP_056618.1","22912588","Mutation of a mammalian phosphatidylserine translocase causes axon degeneration and neurodegenerative disease."
> "Q8BW72-1","RefSeq","NP_759014.2","29054488","High Jmjd2a expression is associated with neuropathic pain."
> "Q8BW72-1","RefSeq","NP_759014.2","28827393","This study dissects an important dual role for maternal Kdm4a in determining faithful early embryonic development and the implantation process."
> "Q8BW72-1","RefSeq","NP_759014.2","28511912","We propose the inhibition of KDM4A activity as a strategy to suppress IL-6 production and attenuate colitis induction."
> "Q8BW72-1","RefSeq","NP_759014.2","27711046","Jmjd2 class demethylases are critical epigenetic regulators involved in etiopathology of depression and related disorders."
> "Q8BTG7-1","RefSeq","NP_663577.1","28524415","NDRG4 is exclusively expressed by central, peripheral and enteric neurons/nerves, suggesting a neuronal-specific role of this protein"
> "Q8BTG7-1","RefSeq","NP_663577.1","27175791","NDRG4 might play an important role during early pregnancy. Publication Status: Online-Only"
> "Q8BTG7-1","RefSeq","NP_663577.1","26780215","Up-regulation of NDRG4 aggravates myocardial ischemia/reperfusion injury by inhibiting activation of the RISK pathway"
> "Q8BTG7-1","RefSeq","NP_663577.1","26801554","Availability of the conditional allele for Ndrg4 should facilitate further detailed analyses of the potential roles of Ndrg4 in gut development, nervous system and immune system."
> "Q8BTG7-1","RefSeq","NP_663577.1","17998568","These expression patterns demonstrated the cell type-specific and ubiquitous localization of the NDRG family proteins. Each NDRG may play a partially redundant role in specific cells in the brain."
> "P27512-1","RefSeq","NP_733805.1","30096208","We here show that loss of macrophage CD40 signaling does not affect obesity induced metabolic dysregulation and indicates that CD40-deficiency on other cell-types than the macrophage is responsible for the metabolic dysregulation, adipose tissue inflammation and hepatosteatosis that are observed in CD40-/- mice. Publication Status: Online-Only"
> "P27512-1","RefSeq","NP_733805.1","29452567","These novel findings suggest that the mechanisms that underlie Ang-II-dependent thrombotic and inflammatory responses link to the signaling of CD40L via both CD40 and VLA5."
16988a22893
> "Q9CQA0-1","RefSeq","NP_840000.2","12881717","A new 20 kDa protein (PANE1) induced upon transdifferentiation was nuclear in nonconfluent cells and cytoplasmic in confluent or dividing cells."
16992d22896
< "P09838-2","RefSeq","NP_001036693.1","27311013","Molecular dynamics simulations and structural analysis to decipher functional impact of a twenty residue insert in the ternary complex of mus musculus TdT isoform have been reported. Publication Status: Online-Only"
17001,17002c22905
< "P48381-1","RefSeq","NP_001159886.1","16930429","These results demonstrate that regulatory factor X3 is necessary for ciliated ependymal cell differentiation in the mouse."
< "P48381-1","RefSeq","NP_001159886.1","15121860","RFX3 is essential for the differentiation of nodal monocilia and hence for LR body axis determination."
---
> "Q61026-1","RefSeq","NP_032704.2","29127200","Results suggest that SRC-2 coordinates cardiomyocyte secretion of VEGF downstream of the two major angiogenic stimuli occurring during pressure overload bridging both hypertrophic and hypoxia-stimulated paracrine signaling."
17014,17018d22916
< "Q64GA5-1","RefSeq","NP_001004762.1","30161143","Validation of differentially expressed genes (DEGs) by quantitative RT-PCR showed a significant increase in PLA2 group 4c (Pla2g4c)/COX-2 (Ptgs2)/PGD2 synthase 2 (Hpgds) axis. PGD2 level in bronchoalveolar fluids of the OA-challenged mice was significantly increased. A 24-h incubation of BSM tissues with PGD2 caused a hyperresponsiveness to acetylcholine in naive control mice. Publication Status: Online-Only"
< "Q64GA5-1","RefSeq","NP_001004762.1","22082005","Results link cytokine-mediated alterations in cPLA2gamma gene expression with allergic asthma and outline a complex regulatory mechanism"
< "Q64GA5-1","RefSeq","NP_001004762.1","20817734","Genetic ablation of calcium-independent phospholipase A2gamma prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation."
< "Q64GA5-1","RefSeq","NP_001004762.1","20452986","CPLA(2) has a role in the induction of cell autonomous cellular immunity to Chlamydia"
< "Q64GA5-1","RefSeq","NP_001004762.1","17213206","IPLA2gamma has roles in the lipid plasticity of myocardium, in generating signaling metabolites, and in modulating energy storage and utilization in myocardium in different metabolic contexts"
17029a22928,22932
> "Q99K90-1","RefSeq","NP_619608.1","30144578","Lipopolysaccharide-induced miR-155 promoted autophagy to increase osteoclast formation via decreased TAB2."
> "Q99K90-1","RefSeq","NP_619608.1","27153994","These findings support a regulatory role for TGF-beta-activated kinase 1 in governing downstream MAPKs/NF-kappaB signaling cascades in the macrophage activation in response to hyperglycemic insult"
> "Q99K90-1","RefSeq","NP_619608.1","26299341","RNF4 negatively regulates NF-kappaB signaling by down-regulating TAB2"
> "Q99K90-1","RefSeq","NP_619608.1","12433684","The expression of mouse TAB2 in the E11 dorsal aorta endothelium suggests a role for mTAB2 in hematopoietic stem cell emergence and/or regulation"
> "Q99K90-1","RefSeq","NP_619608.1","12556483","TAB2 is essential for embryonic development through prevention of liver apoptosis but not for the IL-1 receptor-mediated signaling pathway."
17033a22937,22940
> "Q99MQ4-1","RefSeq","NP_079987.2","30511172","PLAP-1 gets involved in the development of osseous eruption canal."
> "Q99MQ4-1","RefSeq","NP_079987.2","28859141","Asporin deficiency changes skin glycosaminoglycan composition, and decorin and biglycan content, which may explain the changes in skin mechanical properties. Publication Status: Online-Only"
> "Q99MQ4-1","RefSeq","NP_079987.2","17804408","The findings indicate that TGF-beta1 induces ASPN through Smad3 but that this induction is indirect."
> "Q99MQ4-1","RefSeq","NP_079987.2","17522060","PLAP-1/asporin plays a specific role in the periodontal ligament as a negative regulator of cytodifferentiation and mineralization by regulating BMP-2 activity to prevent the periodontal ligament from developing non-physiological mineralization"
17037a22945,22949
> "Q5SV77-1","RefSeq","NP_694784.2","28823874","Demonstrates that GGNBP2 is critically required for maintenance of the adhesion integrity of the adlumenal germ epithelium and is indispensable for normal spermatid transformation into mature spermatozoa in mice"
> "Q5SV77-1","RefSeq","NP_694784.2","28592902","These results suggest that GGNBP2 plays a key role in spermatogenesis by affecting the morphology and function of SOX9-positive Sertoli cells. Publication Status: Online-Only"
> "Q5SV77-1","RefSeq","NP_694784.2","26764350","GGNBP2 is an essential factor for pregnancy success acting through the maintenance of a balance of trophoblast stem cell proliferation and differentiation during placental development."
> "Q5SV77-1","RefSeq","NP_694784.2","15642376","Ggnbp2 is mainly expressed in the testis. Its protein product interacted with GGN1 and could be involved in intracellular trafficking."
> "E9Q732-1","RefSeq","NP_001156533.1","27196371","Nczf is essential for embryonic development and cell proliferation by negatively regulating p27 mRNA expression in mice. Publication Status: Online-Only"
17040a22953,22969
> "Q99NE5-1","RefSeq","NP_898839.2","29891949","Postsynaptic RIM1 in hippocampal CA1 region is required for basal NMDAR-, but not AMPA receptor (AMPAR)-, mediated synaptic responses, and contributes to synaptic plasticity and hippocampus-dependent memory. Moreover, RIM1 levels in hippocampal neurons influence both the constitutive and regulated NMDAR trafficking, without affecting constitutive AMPAR trafficking. Publication Status: Online-Only"
> "Q99NE5-1","RefSeq","NP_898839.2","29606581","RIM C2B domains are constitutive PIP2-binding molecules that couple mechanisms for synaptic vesical priming."
> "Q99NE5-1","RefSeq","NP_898839.2","11797010","Required for presynaptic long-term potentiation."
> "Q99NE5-1","RefSeq","NP_898839.2","11797009","RIM1alpha interacts with several active zone molecules, including Munc13-1 and alpha-liprins, to form a protein scaffold in the presynaptic nerve terminal."
> "E9PX95-1","RefSeq","NP_001026792.2","22237709","Results suggest that ABCA17 plays an important role in the process of sterol efflux which renders spermatozoa capable of fertilizing an oocyte."
> "P33587-1","RefSeq","NP_001300867.1","30305662","There is a predilection of low protein C-induced spontaneous atherothrombosis in Apoe(-/-) mice for the right coronary sinus. Publication Status: Online-Only"
> "P33587-1","RefSeq","NP_001300867.1","29343482","These results support the concept that APC-induced, PAR1-dependent biased signaling following R46 cleavage is central to the in vivo benefits of APC."
> "P33587-1","RefSeq","NP_001300867.1","28687614","Insulin and aPC converge on a common spliced-X-box binding protein-1 (sXBP1) signaling pathway to maintain endoplasmic reticulum (ER) homeostasis."
> "P33587-1","RefSeq","NP_001300867.1","28827518","Data show that activated protein C signals via protease activated receptors PAR2/PAR3 to expand Treg cells, mitigating the disease in mice. Publication Status: Online-Only"
> "P63056-1","RefSeq","NP_703188.1","16115881","Pax6 regulation of Optimedin in the eye and brain may directly affect multiple developmental processes, including cell migration and axon growth"
> "Q9R0H0-1","RefSeq","NP_056544.2","30312667","Study describes an Acox1-deficient cell line presenting the main biochemical characteristics of severe peroxisomal leukodystrophy and will serve as a promising model to further investigate the consequences of a specific microglial peroxisomal beta-oxidation defect on oxidative stress, inflammation and cellular functions."
> "Q8BGD7-1","RefSeq","NP_705781.1","30093305","The observed reduction of the infarct volume was comparable to the protection obtained by intracerebroventricular injection of recombinant Activin A or SerpinB2 or by stereotactic delivery 3 weeks prior to the injury of a recombinant adeno-associated virus containing an expression cassette for the potent neuroprotective transcription factor Npas4"
> "Q8BGD7-1","RefSeq","NP_705781.1","30052197","NPAS4 is an important regulator of plasticity mediated by endogenous cannabinoids. Publication Status: Online-Only"
> "Q8BGD7-1","RefSeq","NP_705781.1","29345055","Results suggest that Npas4 mediates susceptibility to adolescent stress and subsequent cognitive functioning and inhibitory tone in adulthood. This shows a novel gene by environment interaction related to resilience vs vulnerability to stress, with implications for adolescent onset disorders like schizophrenia."
> "Q8BGD7-1","RefSeq","NP_705781.1","29429933","Npas4 is a critical regulator of experience-dependent, functional plasticity at mossy fiber-CA3 pyramidal synapses during contextual memory formation."
> "Q8BGD7-1","RefSeq","NP_705781.1","18815592","Identification of transcription factor Npas4, that plays a role in the development of inhibitory synapses by regulating the expression of activity-dependent genes, which in turn control the number of GABA-releasing synapses that form on excitatory neurons"
> "Q8BGD7-1","RefSeq","NP_705781.1","15380003","MRNA expression in the hippocampus 1 h following generalized convulsive seizure, in a pattern which is typical for other activity-dependant genes expressed in this structure."
17045a22975,22977
> "P83940-1","RefSeq","NP_080732.1","27863226","EPOP (E130012A19Rik) interacts with elongin B, elongin C, and USP7 to modulate the chromatin landscape. Erratum:[Mol Cell. 2017 Jan 5;65(1):202. PMID: 28061330]"
> "P83940-1","RefSeq","NP_080732.1","27863225","EPOP (E130012A19Rik) functionally links elongin B, elongin C, and polycomb in pluripotent stem cells."
> "P83940-1","RefSeq","NP_080732.1","23897481","Crystal structure shows interaction between SOCS2-elongin BC and Cullin-5."
17060a22993,22995
> "Q9WUF3-1","RefSeq","NP_036127.2","26208142","The functional interaction of E2A and FLASH play an important role in cell proliferation and cellular senescence via regulation of p21 expression in experimental glomerulonephritis. Publication Status: Online-Only"
> "Q9WUF3-1","RefSeq","NP_036127.2","23673342","Data suggest that SUMO targets FLASH for proteasome-dependent degradation, which is associated with recruitment of FLASH to PML bodies."
> "Q9WUF3-1","RefSeq","NP_036127.2","21725362","Data show that homozygous deletion of FLASH results in early embryonic lethality."
17064a23000,23002
> "Q8R104-1","RefSeq","NP_071878.2","31015456","Study provides evidence that neuronal networks in the hippocampus of mice adapt to intermittent food deprivation by up-regulating GABAergic inhibitory neurotransmission via a mechanism requiring SIRT3 and involving a reduction in mitochondrial oxidative stress. Publication Status: Online-Only"
> "Q8R104-1","RefSeq","NP_071878.2","17923681","These results extend the recent finding of lysine acetylation of mitochondrial proteins and demonstrate that SIRT3 has evolved to control reversible lysine acetylation in this organelle."
> "Q8R104-1","RefSeq","NP_071878.2","15653680","Results demonstrate that SIRT3 activates mitochondria and plays an important role in adaptive thermogenesis in brown adipose tissue. GeneRIF: Caloric restriction and cold exposure elevate SIRT3 expression in brown adipose to regulate thermogenesis through PGC-1alpha and UCP1."
17068a23007,23009
> "Q9QZS2-1","RefSeq","NP_035408.1","28143738","These findings suggest that the UBC9/PML/RNF4 axis plays a critical role as an important SUMO pathway in cardiac fibrosis. Modulating the protein levels of the pathway provides an attractive therapeutic target for the treatment of cardiac fibrosis and heart failure."
> "Q9QZS2-1","RefSeq","NP_035408.1","24714598","This paper identifies a nucleosome-targeting motif within the RNF4 RING domain that can bind DNA and thereby enables RNF4 to selectively ubiquitinate nucleosomal histones."
> "Q9QZS2-1","RefSeq","NP_035408.1","11866449","GC-rich elements flanking the transcription start site govern activation"
17096a23038,23040
> "Q9Z268-1","RefSeq","NP_038860.2","25616414","Transcriptional suppression of RASAL1 through aberrant promoter methylation contributes to endothelial-mesenchymal transition and ultimately to progression of cardiac fibrosis."
> "Q9Z268-1","RefSeq","NP_038860.2","24480825","Kidney fibrosis is associated with Rasal1 promoter hypermethylation, suppressed Rasal1 expression and suppressed Tet3 expression."
> "Q9Z268-1","RefSeq","NP_038860.2","20418885","We demonstrate here that hypermethylation of RASAL1, encoding an inhibitor of the Ras oncoprotein, is associated with the perpetuation of fibroblast activation and fibrogenesis in the kidney"
17102a23047,23048
> "Q9CQD0-1","RefSeq","NP_080870.1","24452241","Results show the RP paralog Rpl39l is highly expressed in Embryonic Stem Cells and its expression strongly correlates with hepatocellular carcinoma tumor (HCC) samples with high tumor grading and alpha-fetoprotein level giving it diagnostic potential."
> "Q9CQD0-1","RefSeq","NP_080870.1","17660561","Transcripts highly enriched in ovary; gene identified as candidate female fertility factor."
17123a23070,23076
> "Q60720-1","RefSeq","NP_031831.2","22526465","Dihydrolipoic acid (DHLA)-dependent reduction of these two Cyt-b561 proteins"
> "Q60720-1","RefSeq","NP_031831.2","21045261","Expression of Cytochrome b561, is androgen regulated in the context of CaP cells and its increased expression in castration recurrent prostate cancer reflects increased androgen receptor signaling in tumor cells"
> "Q60720-1","RefSeq","NP_031831.2","14499595","Data show that four members of the b561 family of predicted ferric reductases:  mouse cytochrome b561, human duodenal cytochrome b, and mouse stromal cell-derived receptor 2, have ferric reductase activity."
> "Q8BVN3-1","RefSeq","NP_808534.1","18607386","Data show that spinal cord injury doesn't significantly change the expression of CatSpers 4."
> "Q8BVN3-1","RefSeq","NP_808534.1","17344468","Catsper3 and Catsper4 knockout male mice are completely infertile due to a quick loss of motility and a lack of hyperactivated motility under capacitating conditions."
> "Q8BVN3-1","RefSeq","NP_808534.1","16107607","CATSPER4 is a cation-channel protein and has role in acrosome reaction and male fertility"
> "Q8BVN3-1","RefSeq","NP_808534.1","12932298","Catsper4 has a single channel-forming domain, a pore-loop with the consensus sequence TxDxW, & a coiled-coil protein-protein interaction domain in the C-terminal tail. CatSpers 1,2,3 & 4 may interact directly or indirectly to form a functional tetramer. Publication Status: Online-Only"
17132a23086,23091
> "Q769J6-1","RefSeq","NP_001277392.1","29729651","ADAMTS13 knockout promotes the occurrence of early brain injury after experimental subarachnoid hemorrhage."
> "Q769J6-1","RefSeq","NP_001277392.1","28495930","ADAMTS13 retards progression of diabetic nephropathy, most likely by inhibiting VWF-dependent intrarenal thrombosis."
> "Q769J6-1","RefSeq","NP_001277392.1","17426255","The plasma ADAMTS13 activity levels of mouse strains segregated into a high and a low group. Low ADAMTS13 activity was detected in mice containing 2 alleles of intracisternal A-type particle (IAP) retrotransposon sequence"
> "Q769J6-1","RefSeq","NP_001277392.1","15806136","Identification of the liver cell-type expressing ADAMTS13 will have is important for understanding pathophysiological mechanisms regulating ADAMTS13 expression."
> "Q769J6-1","RefSeq","NP_001277392.1","15869605","Characterization of the full-length murine ADAMTS13"
> "Q769J6-1","RefSeq","NP_001277392.1","15136581","Analysis of strain-specific variants of mouse Adamts13 gene encoding von Willebrand factor-cleaving protease"
17145a23105,23107
> "Q6URW6-1","RefSeq","NP_082297.1","27385019","We have validated a novel gene, Myh14, as a negative regulator of ISO-induced left ventricular mass hypertrophy in an in vivo mouse model and demonstrated the up-regulation of immediate early gene Myc, fetal gene Nppb, and fibrosis gene Lgals3 in ISO-treated Myh14 deficient hearts compared to controls. Publication Status: Online-Only"
> "Q6URW6-1","RefSeq","NP_082297.1","28101381","That Myh14 may play a beneficial role in the protection of the cochlea after acoustic overstimulation in CBA/CaJ mice"
> "Q6URW6-1","RefSeq","NP_082297.1","12598534","A cGMP-independent mechanism for nitric oxide-mediated inhibition of nonmuscle myosin heavy chain II-C induction"
17162a23125,23127
> "P97783-1","RefSeq","NP_064298.1","29069662","Aberrant expression of AF1q may activate Wnt/beta-catenin signaling and result in podocyte injury"
> "P97783-1","RefSeq","NP_064298.1","24839873","MLLT11 is a pan-neuronal marker, suggesting a role in neural differentiation in the central nervous system and neural crest-cell derived peripheral ganglia"
> "P97783-1","RefSeq","NP_064298.1","15530661","The mouse Af1q, homologue of human AF1q, was found to be significantly up-regulated during the neuronal production from neural stem cells"
17165,17168c23130,23135
< "P97368-1","RefSeq","NP_001289401.1","22987645","Data have demonstrated the presence of Meis, Pbx, and Prep proteins during early lineage segregation in mammals: Meis1, Meis3, Pbx1, Pbx2, Pbx3, and Prep1 in the mouse."
< "P97368-1","RefSeq","NP_001289401.1","21059917","Meis3 is abundantly expressed in pancreatic islets and beta-cells and regulates beta-cell survival through 3-phosphoinositide-dependent protein kinase 1 (PDK1)."
< "P97368-1","RefSeq","NP_001289401.1","18223676","Novel collaboration between Icsbp deficiency and Meis1/Meis3 in the acceleration of chronic myeloid leukemia-like disease."
< "P97368-1","RefSeq","NP_001289401.1","12397630","The mRNA level of this protein was elevated in limb buds after treatment with ectopic acid."
---
> "P15314-1","RefSeq","NP_032416.1","30315525","IRF-1 deficiency plays a key role in moderating the excessive NETs formed via ROS in the classical pathway and retaining the protective role of the low-NET levels generated in early/rapid NETosis"
> "P15314-1","RefSeq","NP_032416.1","30342302","Interferon Regulatory Factor 1 (IRF-1), a tumor suppressor and an antiviral host factor, selectively suppresses an endogenous retroviruses (ERVs) expression. IRF-1 suppresses endogenous reverse transcriptase activity of interferon-beta treated primary macrophages and mouse embryonic fibroblasts. Specific ERV expression is suppressed in both lung and spleen of IRF-1-/- mice."
> "P15314-1","RefSeq","NP_032416.1","30348900","Results demonstrate distinct roles of IRF1 in hepatic inflammation (HSCs) and injury (hepatocytes) and can be an important target for intervention in acute liver injury"
> "Q9D808-1","RefSeq","NP_598871.1","28280005","These results demonstrate that KCNE2 is required for normal beta-cell electrical activity and insulin secretion, and that Kcne2 deletion causes T2DM."
> "Q9D808-1","RefSeq","NP_598871.1","26952045","Kcne2 deletion preconditions the heart, attenuating the acute tissue damage caused by an imposed ischaemia/reperfusion injury"
> "Q9D808-1","RefSeq","NP_598871.1","16754665","KCNE2 is essential for gastric acid secretion, the first genetic evidence that a member of the KCNE gene family is required for normal gastrointestinal function."
17178a23146
> "P29752-1","RefSeq","NP_034809.1","15141307","A folding variant of alpha-lactalbumin has a role in lactating mammary gland apoptosis"
17192a23161,23164
> "Q9ES83-1","RefSeq","NP_077247.1","28389570","BVES plays a key role in maintaining the integrity of the colonic mucosa and protecting from inflammatory carcinogenesis. Additionally, these results provide the first in vivo and genetic evidence supporting the hypothesis that BVES regulates Wnt activity."
> "Q9ES83-1","RefSeq","NP_077247.1","26891025","BVES is a key regulator of intestinal stem cell programs and mucosal homeostasis."
> "Q9ES83-1","RefSeq","NP_077247.1","24066022","The results indicate that Popdc1 is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity and for heart protection. Publication Status: Online-Only"
> "O09112-1","RefSeq","NP_032774.1","27225478","DUSP8 controls stress-induced ERK1/2 signaling in cardiac myocytes."
17195,17199c23167,23169
< "P39688-1","RefSeq","NP_001116365.1","30658076","MiR-125a-3p exerts anti-fibrotic effects in silica-induced pulmonary fibrosis by regulating Fyn/STAT3 signaling."
< "P39688-1","RefSeq","NP_001116365.1","29661967","Our results suggest that Fyn-mediated regulation of the cell-cell adhesion of neuroblasts is critical for their detachment from chains in the postnatal brain"
< "P39688-1","RefSeq","NP_001116365.1","29353218","These results suggest that Nrf2 plays a central role in the prevention of Ang II-induced cardiomyopathy, and SFN prevents Ang II-induced cardiomyopathy partially via the Akt/GSK-3beta/Fyn-mediated Nrf2 activation."
< "P39688-1","RefSeq","NP_001116365.1","29180007","These results suggested that Fyn has a regulatory role in iNOS expression in astrocytes during neuroinflammatory responses."
< "Q69Z26-1","RefSeq","NP_001103219.1","27539848","Protein-tyrosine phosphatase receptor type G (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system"
---
> "Q9JI70-1","RefSeq","NP_067502.2","30446775","Loss of Bardet-Biedl Syndrome proteins (BBS) proteins Bbs6 and Bbs8 affects ciliated retinal pigment epithelium (RPE)."
> "Q9JI70-1","RefSeq","NP_067502.2","23671934","Three uORFs (uMKKS0, uMKKS1 and uMKKS2) are reported, and they can repress the translation of the downstream MKKS ORF. uMKKS1 and uMKKS2 are highly conserved in mammals and they encode two different mitochondrial membrane proteins respectively."
> "Q9JI70-1","RefSeq","NP_067502.2","15731008","MKKS/BBS6 is a novel centrosomal component required for cytokinesis"
17200a23171,23172
> "Q9JM61-1","RefSeq","NP_062522.1","26822228","THSD1 is a new regulator of endothelial barrier function during vascular development and protects intraplaque microvessels against haemorrhaging in advanced atherosclerotic lesions"
> "Q9JM61-1","RefSeq","NP_062522.1","16455951","Expression profiling of Tmtsp demonstrated its specific expression in hematopoietic and endothelial cells"
17205a23178,23180
> "O08796-1","RefSeq","NP_031934.1","28502587","This study provides new insights into the control of eEF2K by AMPK."
> "O08796-1","RefSeq","NP_031934.1","27752775","EEF2K activity is increased in postmortem Alzheimer's disease (AD) patient cortex and hippocampus, and in the hippocampus of aged transgenic AD mice. eEF2K inhibition using pharmacological or genetic approaches prevented the toxic effects of Abeta42 oligomers on neuronal viability and dendrite formation in vitro. Findings highlight the potential utility of eEF2K inhibition to reduce Abeta-mediated oxidative stress in AD."
> "O08796-1","RefSeq","NP_031934.1","12213630","During late embryonic and early postnatal stages, elongation factor 2 kinase is up-regulated in the cerebral cortex and hippocampal pyramidal cell layer."
17220a23196,23200
> "Q924Z4-1","RefSeq","NP_084065.1","29653252","Gene expression analyses in livers of transgenic mouse mutants revealed that inactivation of CerS2 catalytic activity largely affects transcription of genes involved in lipid metabolism and cell division and is associated with the formation of hepatocellular carcinoma in 6 to 8-week-old mice."
> "Q924Z4-1","RefSeq","NP_084065.1","29626628","Our findings indicate that LASS2 plays an important role in the pathogenesis of diet-induced hepatic steatosis"
> "Q924Z4-1","RefSeq","NP_084065.1","28958935","LASS2 plays an important role in efficient liver regeneration in response to partial hepatectomy."
> "Q924Z4-1","RefSeq","NP_084065.1","19801672","Results indicate that CERS2 activity supports different biological functions: maintenance of myelin, stabilization of the cerebellar as well as renal histological architecture, and protection against hepatocarcinomas."
> "Q924Z4-1","RefSeq","NP_084065.1","18165233","Activity of CerS2 can be regulated by another bioactive sphingolipid, sphingosine 1-phosphate"
17236a23217
> "Q8BHZ5-1","RefSeq","NP_954596.1","17043244","Characterizes the hamster ortholog and suggests that it may modulate the ability of the proteasome to degrade retroviral cores upon cellular infection."
17245a23227,23231
> "Q8R550-1","RefSeq","NP_067364.2","29589748","Competitive analytical gel-filtration chromatography and isothermal titration calorimetry (ITC) results showed that ARAP1 could compete with Cbl for CIN85 binding, which provides a biochemical basis for the regulatory roles of ARAP1 in the CIN85-mediated EGFR internalizing process."
> "Q8R550-1","RefSeq","NP_067364.2","29158391","Cin85-deficient mother mice had reduced pituitary hormone prolactin secretion as a result of excessive dopamine signaling in the brain. Their offspring matured normally and produced their own pups; however, nurturing behaviors such as pup retrieval and nursing were strongly inhibited."
> "Q8R550-1","RefSeq","NP_067364.2","27531950","CIN85/RukL is involved in endocytosis of nephrin in podocytes under diabetic conditions, causing podocyte depletion and promoting proteinuria. CIN85/RukL expression therefore shows potential to be a novel target for antiproteinuric therapy in diabetes."
> "Q8R550-1","RefSeq","NP_067364.2","12177062","CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases"
> "Q8R550-1","RefSeq","NP_067364.2","12242006","Analysis of cDNA clones, ESTs and products of RT-PCR amplifications with different combinations of primers revealed how alternative splicing and promoter usage generate a variety of Ruk transcripts and encoded protein isoforms in different mouse tissues."
17254,17255d23239
< "Q9D424-1","RefSeq","NP_001035883.1","27802166","It is the role of CABYR in the formation of the fibrous sheath that is essential for male fertility."
< "Q9D424-1","RefSeq","NP_001035883.1","20731842","CABYR expresses at the late stage of spermiogenesis and its isoforms oligomerize and bind with AKAPs and ropporin; which suggests that CABYR participates in the assembly of the fibrous sheath. Publication Status: Online-Only"
17269a23254,23255
> "Q80Z24-1","RefSeq","NP_796248.1","26723899","The long non-coding RNA, BC048612, and microRNA-203 were determined to be positive and negative regulators of Negr1 gene expression respectively."
> "Q9R160-1","RefSeq","NP_034216.3","19670298","Findings suggest that testase 1 is a sperm plasma membrane component which contributes to the prevention of polyspermy at the level of the oocyte plasma membrane."
17277a23264
> "Q922K9-1","RefSeq","NP_034367.2","17416457","These results show that FRK affects beta cell number during embryogenesis and early in life, but is probably redundant for beta cell number and function in adult animals under normal conditions."
17293a23281,23284
> "Q08048-1","RefSeq","NP_034557.3","30627913","It can be assumed that Sema3a synthesized in the thymus stroma can act as a functional antagonist of HGF and KGF and have an inhibitory effect when these growth factors are administered into the body for the therapeutic purpose of restoring thymus functions."
> "Q08048-1","RefSeq","NP_034557.3","30401749","Activation of hepatocyte growth factor/MET signaling initiates oncogenic transformation and enhances tumor aggressiveness in the murine prostate."
> "Q08048-1","RefSeq","NP_034557.3","30103949","C-Fos is necessary for HGF-mediated gene regulation and cell migration in Schwann cells."
> "Q08048-1","RefSeq","NP_034557.3","30066918","These results suggested that HGF may exert beneficial effects on type II diabetesinduced chronic renal failure via regulation of the NFkappaB signaling pathway."
17300a23292
> "F2Z493-1","RefSeq","NP_064676.2","14739298","A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis"
17306a23299,23306
> "Q91ZD6-1","RefSeq","NP_598872.1","29029019","Data show that p53 and EAF2 knockout mice developed prostate cancer."
> "Q91ZD6-1","RefSeq","NP_598872.1","26935903","These results demonstrate that EAF2-mediated apoptosis in GC B cells limits excessive humoral immune responses and is important for maintaining self-tolerance. Publication Status: Online-Only"
> "Q91ZD6-1","RefSeq","NP_598872.1","26328919","The results showed that Eaf2 knockout can reduce UV-induced apoptosis in crystalline lenses and mitigate the formation of cataracts."
> "Q91ZD6-1","RefSeq","NP_598872.1","24260246","Mice deficient in EAF2 had an increased recovery rate and a decreased overall response to the effects of androgen deprivation. Publication Status: Online-Only"
> "Q91ZD6-1","RefSeq","NP_598872.1","17873910","Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia"
> "Q91ZD6-1","RefSeq","NP_598872.1","17892859","Transcriptional activation mediated by FESTA/EAF2, a transcription factor that interacts with S-II, was decreased in RNA polymerase II deficient embryonic stem cells."
> "Q91ZD6-1","RefSeq","NP_598872.1","14517999","Expression of Eaf2 is developmentally regulated."
> "G3X9I7-1","RefSeq","NP_001030079.2","18178554","MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a, Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage activation."
17313a23314
> "Q9QZ47-1","RefSeq","NP_035750.2","28008709","TnT3 regulates expression of Cav1.1 in skeletal muscle, this regulation is impaired in aging."
17317,17318d23317
< "Q8K202-1","RefSeq","NP_001272729.1","28042089","DNA sequencing demonstrated that in the absence of ectopic PAF53 expression, cells demonstrated unique means of surviving; including recombination or the utilization of alternative reading frames. We never observed a clone in which one PAF53 gene is expressed, unless there was also ectopic expression In the absence of ectopic gene expression, the gene products of both endogenous genes were expressed, irrespective of wheth"
< "Q8K202-1","RefSeq","NP_001272729.1","22849406","Yeast A34.5/A49 and mammalian PAF49/PAF53 heterodimeric complexes interact through species-specific sequence elements that appear to assume similar structural motifs."
17321a23321,23322
> "Q6DFV5-1","RefSeq","NP_938040.1","21765940","Downregulation of HELZ reduced translational initiation, resulting in the disassembly of polysomes, in a reduction of cell proliferation and hypophosphorylation of ribosomal protein S6."
> "Q6DFV5-1","RefSeq","NP_938040.1","20305823","Smyd2, similar to Smyd3, interacts with RNA Polymerase II as well as to the RNA helicase, HELZ Publication Status: Online-Only"
17323a23325,23331
> "Q09143-1","RefSeq","NP_031539.3","27357826","A time-dependent decrease in serum and tissue ADMA and increase in mRNA expression of DDAH-1 and PRMT-1 as well as higher rates of mRNA expression of CAT-1 and lower rates of CAT-2A and CAT-2B were found after 8-week MCD diet."
> "Q09143-1","RefSeq","NP_031539.3","25115333","Endothelial CAT-1 overexpression can counter the ability of oxidative stress."
> "Q09143-1","RefSeq","NP_031539.3","23009292","L-argine transporters CAT-1 and CAT-2A expression and function are significantly increased in Duchenne muscular dystrophy mice."
> "Q61168-1","RefSeq","NP_034816.1","24638062","These results suggest that CD3zeta can be degraded by two pathways: SLAP/c-Cbl, which targets internalized cell surface CD3zeta dependent on TCR signaling, and LAPTM5, which targets intracellular CD3zeta independent of TCR signaling."
> "Q61168-1","RefSeq","NP_034816.1","22949502","The pre-BCR induces the downmodulation of its own expression through induction of LAPTM5, which promotes the lysosomal transport and degradation of the intracellular pre-BCR pool and limits the supply of pre-BCR to the cell surface"
> "Q61168-1","RefSeq","NP_034816.1","22733818","LAPTM5 acts as a positive modulator of inflammatory signaling pathways and hence cytokine secretion in macrophages"
> "P97497-1","RefSeq","NP_035497.1","30046278","SHBG suppresses inflammation and lipid accumulation in macrophages and adipocytes, which might be among the mechanisms underlying the protective effect of SHBG, that is, its actions which reduce the incidence of metabolic syndrome Publication Status: Online-Only"
17337a23346
> "Q9Z1J2-1","RefSeq","NP_035979.1","20103636","Data show that after Taxol treatment, Nek4 promoted microtubule outgrowth, whereas Nek4 deficiency impaired G(2)-M arrest and decreased formation of mitotic-like asters."
17339a23349,23351
> "Q9QYF9-1","RefSeq","NP_038893.1","29096585","Data suggested that n-myc downstream-regulated gene 3 might play an important role in embryo implantation by regulating decidualization potentially via the estrogen/progesterone/miR-290b-5p pathway."
> "Q9QYF9-1","RefSeq","NP_038893.1","28290521","We reported that Ndrg3 gene modulated the lactate induced ERK pathway to facilitate DSB repair in male germ cells, which further regulated meiosis and subsequently fertility in male mouse. Publication Status: Online-Only"
> "Q9QYF9-1","RefSeq","NP_038893.1","17998568","These expression patterns demonstrated the cell type-specific and ubiquitous localization of the NDRG family proteins. Each NDRG may play a partially redundant role in specific cells in the brain."
17348,17351d23359
< "Q8BPU7-1","RefSeq","NP_525027.1","30643265","Loss of the engulfment signaling protein Elmo1 alleviated disease severity in mouse models of arthritis through Elmo1's regulation of neutrophil recruitment to inflamed joints."
< "Q8BPU7-1","RefSeq","NP_525027.1","30219846","ELMO1 protects against DSS-induced colonic injury in mice through its effect on epithelial migration via Rac1 activation."
< "Q8BPU7-1","RefSeq","NP_525027.1","29029244","ELMO1 is present in the phagosome and enhances bacterial clearance by differential regulation of lysosomal acidification and enzymatic activity."
< "Q8BPU7-1","RefSeq","NP_525027.1","28219480","The authors identify ELMO1 as a novel target of TGFbeta signaling and show that restoration of Tgfbr2 results in a complete block of ELMO1 in vivo. Knocking down Elmo1 impairs metastasis of carcinoma cells to the lung, thereby providing insights into the mechanisms of progression of Tgfbr2-deficient invasive transition zone squamous cell carcinoma. Publication Status: Online-Only"
17353,17355c23361,23372
< "Q4VBE4-1","RefSeq","NP_001276425.1","26091521","Pikachurin Protein Required for Increase of Cone Electroretinogram B-Wave during Light Adaptation Publication Status: Online-Only"
< "Q4VBE4-1","RefSeq","NP_001276425.1","21129441","These results indicate that pikachurin interactions with alpha-dystroglycan and its localization at the photoreceptor ribbon synapse require normal glycosylation of alpha-dystroglycan."
< "Q4VBE4-1","RefSeq","NP_001276425.1","20682766","Post-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization."
---
> "Q9Z0U1-1","RefSeq","NP_035727.2","30291936","Based on results obtained in cultured epithelial cells transfected with ZO-2 mutated at a MET target lysine residue."
> "Q9Z0U1-1","RefSeq","NP_035727.2","29845705","Podocyte-specific deletion of the ZO-2 gene did not cause overt defects; however, double knockout of ZO-1 and ZO-2 genes accelerated the defects observed in ZO-1 knockout mice. These results suggest that ZO-2 plays supportive roles in the ZO-1-dependent regulation of podocyte filtration barrier."
> "Q9Z0U1-1","RefSeq","NP_035727.2","28420508","In the present study, we found that the protein level of ZO-2, a scaffolding tight junction protein, decreased in the bladder of OVX mice indicating a possible role in overactive bladder."
> "P58019-1","RefSeq","NP_862906.1","27729184","Data (including data from studies using knockout mice) suggest that CD59a, CD59b, and ApoE are involved in development of diabetes-induced atherosclerosis; here, deficiency of CD59a/CD59b (in ApoE deficient mice) accelerates development of atherosclerosis in mice with type 1 diabetes. (CD59a = CD59a antigen; CD59b = CD59b antigen; ApoE = apolipoprotein E)"
> "P58019-1","RefSeq","NP_862906.1","12594949","Cd59b knockout mice present a phenotype characterized by hemolytic anemia, platelet activation and a progressive loss of fertility associated with immobile dysmorphic and fewer sperm cells after 5 months of age."
> "P58019-1","RefSeq","NP_862906.1","11471050","Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59b."
> "P13808-1","RefSeq","NP_033233.2","27592379","Data indicate a key functional role of anion exchanger 2 (AE2) in the maintenance of the normal physiology of biliary epithelial cells (BEC) and the pathogenic consequences of reduced AE2 expression, including abnormal intrinsic characteristics of BEC and their production of signal molecules that lead to the chronic inflammatory responses in small bile ducts."
> "P13808-1","RefSeq","NP_033233.2","27391897","Results strongly suggest that Ae2 is a critical factor in the innate response to C. albicans. This study represents an important contribution to a better understanding of how Dectin-1 expression and fungal clearance is regulated. Publication Status: Online-Only"
> "P13808-1","RefSeq","NP_033233.2","26396175","AE2 deficiency results in intrahepatic T-cell activation and PD-1/PD-L1 mediated deletion, favoring autoimmune cholangitis."
> "Q9Z0H0-1","RefSeq","NP_033993.2","28887320","Increased Cdc7-dependent replication initiation is a hallmark of p53 gain-of function mutations in lung adenocarcinoma."
> "Q9Z0H0-1","RefSeq","NP_033993.2","27401717","Results suggest a new role of Claspin in initiation of DNA replication during normal S phase through the recruitment of Cdc7 that facilitates phosphorylation of Mcm proteins. Publication Status: Online-Only"
> "Q9Z0H0-1","RefSeq","NP_033993.2","24133205","Cdc7 physically and functionally interacts with Nkx2.5 to regulate Myocd promoter activity"
17359,17360c23376
< "P40645-1","RefSeq","NP_001264255.1","30667104","Through alternative splicing, LncRNA C130071C03Riken variants Riken-201 (Riken-201) and Riken-203 (Riken-203) identify the functional role of Rik-201 and Rik-203 in facilitating neural differentiation and further brain development, and elucidate the underlying miRNAs-Sox6-associated molecular mechanisms"
< "P40645-1","RefSeq","NP_001264255.1","17433257","Thus, we successfully identified the Sox6 promoter and its core enhancer and characterized the interactions with regulatory transcription factors."
---
> "P38649-1","RefSeq","NP_109643.3","14601050","The alphaGal epitope expressed by this transfected enzyme in pancreatic cancer cells delays tumor development after transplantation of nude mice."
17362,17366d23377
< "Q8CGM1-1","RefSeq","NP_001277644.1","28894906","Surface expression of Bai2 R619W is markedly reduced relative to wild-type Bai2."
< "Q8CGM1-1","RefSeq","NP_001277644.1","20367554","BAI2 is a functional GPCR regulated by proteolytic processing and activates the NFAT pathway"
< "Q8CGM1-1","RefSeq","NP_001277644.1","16412436","Results point out that brain-specific angiogenesis inhibitor 2 controls VEGF transcription through GA-binding protein under normal conditions and cerebral ischemia."
< "O55042-1","RefSeq","NP_001035916.1","30528390","Variations of amyloid fibrillar morphologies among the aggregates of a-syn mutants, mainly categorized into two groups: twisted fibrils observed for both WT and E46K while straight fibrils for the other mutants."
< "O55042-1","RefSeq","NP_001035916.1","30503521","Common variation at SNCA might modulate PD risk."
17367a23379
> "P46737-1","RefSeq","NP_666068.1","23246432","The deubiquitinating enzyme, BRCC3, is a critical regulator of NLRP3 activity by promoting its deubiquitination."
17370,17374c23382,23386
< "Q9Z0S6-1","RefSeq","NP_067361.2","29129401","Severe individual renal phenotypes in claudin-10 and claudin-16 knockout mice are corrected by the additional deletion of the other claudin."
< "Q9Z0S6-1","RefSeq","NP_067361.2","28771254","ConclusionCLDN10 mutations cause a dysfunction in TJs in several tissues and, subsequently, abnormalities in renal ion transport, ectodermal gland homeostasis, and epidermal integrity."
< "Q9Z0S6-1","RefSeq","NP_067361.2","29145406","Findings suggest that the axis IL-10/claudin-10 is a promising target for the development of therapeutic agents against aggressive melanoma Publication Status: Online-Only"
< "Q9Z0S6-1","RefSeq","NP_067361.2","26340953","Localization of Cldn3, Cldn7 and Cldn10 proteins in the different compartments of murine endometrium up to day 8.5 of pregnancy (dpc) as well as in human endometrium and first trimester decidua"
< "Q9Z0S6-1","RefSeq","NP_067361.2","14698084","Claudin-10 is expressed at the variety of epithelial tissues in the coclea of inner ear including Organ of Corti, stria vascularis, Reissner's membrane, and spiral limbus."
---
> "Q99MB2-1","RefSeq","NP_080458.1","26633713","Study defines the NFAT4/ miR-324-5p/Mtfr1 axis, which participates in the regulation of mitochondrial fission and cardiomyocyte apoptosis. Publication Status: Online-Only"
> "Q99MB2-1","RefSeq","NP_080458.1","20568109","The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic and cellular respiration and may affect male fertility."
> "Q99MB2-1","RefSeq","NP_080458.1","15389597","CHPPR is able to promote mitochondrial fission with a sequence specific mechanism suggesting that this event may be relevant to late stage of chondrocyte differentiation [CHPPR]"
> "Q63ZW6-1","RefSeq","NP_031762.2","27432120","Findings indicate a role for collagen alpha-5(IV) chain (Col4a5) in the regulation of macrophage responses to mycobacterial infection and identify Col4a5 as a potential target for the host-directed anti-mycobacterial therapy."
> "Q63ZW6-1","RefSeq","NP_031762.2","27377778","Although alpha5 and alpha6 (IV) chains are induced in the glomerular basement membrane in autosomal recessive Alport syndrome, their induction does not seem to play a major compensatory role Publication Status: Online-Only"
17381a23394,23395
> "O35474-1","RefSeq","NP_034233.1","12074641","Acts as an angiogenic factor in the context of solid tumor formation; the increase in vascularization accelerates tumor growth through decreased apoptosis"
> "O35474-1","RefSeq","NP_034233.1","11959660","Mediates vascular smooth muscle cells adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3)"
17386,17388c23400,23402
< "Q64373-1","RefSeq","NP_001276645.1","29704100","Depletion of miR-34a facilitated endothelial cell growth and blocked apoptosis in AS by upregulating Bcl-2, offering a promising avenue for AS therapy."
< "Q64373-1","RefSeq","NP_001276645.1","30261081","Examined the roles of BCL2 proteins in the induction of apoptosis in cells upon infection with flaviviruses, such as Japanese encephalitis virus, Dengue virus and Zika virus. Showed that survival of the infected cells depends on BCLXL, a pro-survival BCL2 protein due to suppression of the expression of another pro-survival protein, MCL1. Publication Status: Online-Only"
< "Q64373-1","RefSeq","NP_001276645.1","30154103","Data indicate a role for ROR-gamma (RORgammat) and Bcl-XL protein (Bcl-xL) in limiting interleukin 2 receptor gamma chain (gammac) abundance at the cell surface. Publication Status: Online-Only"
---
> "G3UWC3-1","RefSeq","NP_001095117.1","24877622","The medial amygdala-medullary PrRP-synthesizing neuron pathway plays an important role in neuroendocrine responses to contextual conditioned fear"
> "G3UWC3-1","RefSeq","NP_001095117.1","19540425","Data report that PrRP and its receptor, GPR10, were found in the mouse substantia nigra pars compacta (SNpc), the main location of dopaminergic (DA) neurons of the nigrostriatal system."
> "G3UWC3-1","RefSeq","NP_001095117.1","17410546","These results suggest that p53 may regulate the differentiation of trophoblast giant cells, and may control the physiological PrRP stimuli in mouse placentas."
17402a23417,23422
> "P17532-1","RefSeq","NP_033440.1","30931940","Overexpression of tryptophan hydroxylase-1 (TPH-1), an enzyme involved in 5-methoxytryptophan synthesis, reduces renal injury by attenuating renal inflammation and fibrosis, whereas TPH-1 deficiency exacerbates renal injury and fibrosis by activating NF-kappaB and inhibiting Nrf2 pathways. Publication Status: Online-Only"
> "P17532-1","RefSeq","NP_033440.1","30446669","Both gut-specific Tph1 knockout mice and liver-specific Htr2a knockout mice are resistant to high fat diet-induced hepatic steatosis, without affecting systemic energy homeostasis. Erratum:[Nat Commun. 2019 Jan 8;10(1):158. PMID: 30622275] Publication Status: Online-Only"
> "Q8BYR5-1","RefSeq","NP_001239034.1","30594389","The data suggest that CADPS2-mediated secretion of BDNF/NT-3 may be involved in development and maturation of synapses and in the balance between inhibitory and excitatory synapses."
> "Q8BYR5-1","RefSeq","NP_001239034.1","29689341","Study looked at synaptic microstructures of hippocampal mossy fiber (MF) terminals in Calcium-dependent activator protein for secretion 2 (Cadps2) knockout mice. Findings suggest that CADPS2 plays a critical role in MF synaptic development and functional organization."
> "Q8BYR5-1","RefSeq","NP_001239034.1","14715936","Results suggest that CAPS2 mediates the depolarization-dependent release of NT-3 and BDNF from granule cells, leading to regulation in cell differentiation and survival during cerebellar development"
> "Q8BYR5-1","RefSeq","NP_001239034.1","14530279","Identification, cloning, and comparative characterization of a second mammalian CAPS isoform, CAPS2; concluded that at the functional level, CAPS2 is largely redundant with CAPS1"
17411a23432,23435
> "A2A7B5-1","RefSeq","NP_001074824.3","26709097","RIZ1 is an important regulator of both Akt3 transcription and AKT phosphorylation and suggest a role for RIZ1 in HF-induced obesity and the AKT pathway"
> "A2A7B5-1","RefSeq","NP_001074824.3","20417662","RIZ1 might participate osteoclast formation through the regulation of NFATc1 expression."
> "A2A7B5-1","RefSeq","NP_001074824.3","20557878","Prevents lipopolysaccharide-induced proinflammatory cytokine production via enhancing nuclear factor-kappaB activation"
> "A2A7B5-1","RefSeq","NP_001074824.3","15282304","Data suggest that the histone methyltransferase RIZ1 is required for estrogen response in female reproductive tissues and that estrogen-bound estrogen receptors may turn a transcriptional repressor into a coactivator."
17417a23442,23445
> "P70698-1","RefSeq","NP_058028.2","24008161","CTPS1 inhibition selectively blocks smooth muscle cell proliferation without disturbing or even promoting re-endothelialization for effective vascular repair after injury."
> "P70698-1","RefSeq","NP_058028.2","22730407","Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway."
> "O35310-1","RefSeq","NP_034604.1","25325966","The expression of heparan sulfate sulfotransferases was examined by in situ hybridization."
> "O35310-1","RefSeq","NP_034604.1","15096036","In this paper a conformational change is described that occurs in heparan sulfate 3-O-sulfotransferase-1 upon binding to heparan sulfate."
17424a23453,23454
> "P60894-1","RefSeq","NP_659503.1","22697179","The results indicate that SREB2 is a negative regulator of adult neurogenesis and consequential cognitive functions."
> "P60894-1","RefSeq","NP_659503.1","18413613","Theses data implicate SREB2 as a potential risk factor for psychiatric disorders."
17428,17432c23458,23459
< "Q9Z1T6-2","RefSeq","NP_001297553.1","30295876","Enlarged vacuole formation in PIKfyve-deficient cells was not rescued by Ca2+ or over expression of TRPML1. It is likely that the acidification and vacuolation arrest is bifurcating downstream of PIKfyve"
< "Q9Z1T6-2","RefSeq","NP_001297553.1","29584722","These studies identify a novel role for PIKfyve in controlling the delivery of proteins from the endosomal compartment to the melanosome, a role that is distinct from the role of PIKfyve in the reformation of lysosomes from endolysosomes. Publication Status: Online-Only"
< "Q9Z1T6-2","RefSeq","NP_001297553.1","28779020","This study shows that PIKfyve coordinates the neutrophil immune response through the activation of the Rac GTPase"
< "Q9Z1T6-2","RefSeq","NP_001297553.1","28533230","Thus, PIKfyve plays a role in preventing excessive lung inflammation through regulating alveolar macrophage function."
< "Q9Z1T6-2","RefSeq","NP_001297553.1","28396567","The authors provide evidence that inactivation of PIKfyve by the selective inhibitor STA suppresses excessive mitochondrial reactive oxygen species production and apoptosis through a SIRT3-dependent pathway in cardiomyoblasts."
---
> "Q3U214-1","RefSeq","NP_955012.2","28167675","We describe a novel mechanism of signal transduction enriched in medium spiny neurons of striatum that likely mediates effects of the neurotransmitter dopamine acting on these cells. We find that the protein ARPP-16, which is highly expressed in striatal medium spiny neurons, acts as a selective inhibitor of certain forms of the serine/threonine protein phosphatase, PP2A, when phosphorylated by the kinase, MAST3."
> "Q3U214-1","RefSeq","NP_955012.2","18650832","As in human immune cells, murine Mast3 is constitutively expressed in CD4-positive and CD8-positive T cells and CD19-expressing B cells."
17441a23469
> "B2KF05-1","RefSeq","NP_001074784.1","26677226","These results indicate that BRPF3 forms a functional tetrameric complex with HBO1 but is not required for mouse development and survival"
17444a23473,23474
> "O88561-1","RefSeq","NP_036118.2","20603810","Analysis of mRNA abundance and expression of SLC27A, ACC, SCD, FADS, LPIN, INSIG, and PPARGC1 gene isoforms in mouse mammary glands during the lactation cycle Publication Status: Online-Only"
> "O88561-1","RefSeq","NP_036118.2","15469937","Studies cast doubt on the designation of very long-chain acyl-CoA synthetase 3 (ACSVL3) as a fatty acid transport protein"
17445a23476,23479
> "Q8R0Y6-1","RefSeq","NP_081682.1","17111379","These data provide the first evidence for localized differences in folate metabolism within the early neural tube and suggest that folate might modulate proliferation via effects on midline Aldh1l1(+) cells."
> "P19785-1","RefSeq","NP_031982.1","30635563","ERalpha-expressing Kiss1 arcuate nucleus neurons are central to restraining a powerful brain-bone axis in female mice. Publication Status: Online-Only"
> "P19785-1","RefSeq","NP_031982.1","30565563","We demonstrate that in the presence of E2, NKB signaling induces LH release in a kisspeptin-independent manner through the activation of NK3R (NKB receptor) neurons in the posterodorsal medial amygdala (MePD). Importantly, we show that chemogenetic activation of MePD Kiss1 neurons induces LH release, however, the stimulatory action of NKB in this area is Kiss1 neuron-independent. Publication Status: Online-Only"
> "P19785-1","RefSeq","NP_031982.1","30413705","Deletion of AF-1 or AF-2 domains of ERalpha blocks pubertal ductal growth and subsequent development because both are required for expression of essential paracrine mediators. Publication Status: Online-Only"
17448c23482,23497
< "Q00731-1","RefSeq","NP_001273985.1","30974834","Findings demonstrate that COX-2 activity is important in the recruitment of VEGF-secreting Ly6C(high) monocytes, which are involved in VILI pathogenesis, and indicate that the suppression of COX-2 activity might be a useful strategy in mitigating ventilator-induced lung injury. Publication Status: Online-Only"
---
> "Q8K1X4-1","RefSeq","NP_705725.1","29915352","Required for the engraftment of fetal liver hematopoietic stem cells in the marrow during embryonic development Publication Status: Online-Only"
> "Q8K1X4-1","RefSeq","NP_705725.1","23424621","A novel, critical role for Hem-1 in the homeostasis of structural proteins required for formation and stability of the actin membrane skeleton in erythrocytes"
> "Q8K1X4-1","RefSeq","NP_705725.1","19015308","Results demonstrate that Hem1 is essential for hematopoietic cell development, function, and homeostasis by controlling a distinct pathway leading to cytoskeletal reorganization"
> "Q9DCB1-1","RefSeq","NP_778249.1","26112184","Hmgn3 may play an important role during mouse decidualization."
> "Q9DCB1-1","RefSeq","NP_778249.1","23620591","Phenotypic analysis of Hmgn1(tm1/tm1), Hmgn3(tm1/tm1), and Hmgn5(tm1/tm1) mice and their wild type littermates with a battery of standardized tests uncovered variant-specific abnormalities."
> "Q9DCB1-1","RefSeq","NP_778249.1","15082770","Results suggest that HMGN3 regulates glycine transporter 1 expression and demonstrate that members of the HMGN family can regulate the transcription of specific genes"
> "Q9R0Z9-1","RefSeq","NP_056617.2","30028837","Talin unfolding determines DLC1 downstream signalling and, consequently, cell mechanics. Publication Status: Online-Only"
> "Q9R0Z9-1","RefSeq","NP_056617.2","29202196","Low DLC1 expression is associated with Angiosarcoma."
> "Q9R0Z9-1","RefSeq","NP_056617.2","28408355","DLC-1 has a positive regulatory role in endothelial cell angiogenesis."
> "Q9R0Z9-1","RefSeq","NP_056617.2","20199662","The Dlc1 deficient cells showed altered cytoskeleton structure, increased RhoA activity and cellular migration. Publication Status: Online-Only"
> "Q9R0Z9-1","RefSeq","NP_056617.2","18519636","Our data validate DLC1 as a potent tumor suppressor gene and suggest that its loss creates a dependence on the RhoA pathway that may be targeted therapeutically."
> "Q9R0Z9-1","RefSeq","NP_056617.2","15710412","DLC-1-/- embryos had defects in the neural tube, brain, heart, and placenta"
> "Q8BGR5-1","RefSeq","NP_997638.1","25183871","Simplet/Fam53b is required for Wnt signal transduction by regulating beta-catenin nuclear localization."
> "Q5U4D8-1","RefSeq","NP_808538.1","28052864","This study shows for the first time that LPS inhibits colonic biotin uptake via decreasing membrane expression of its transporter and that these effects likely involve a CK2-mediated pathway."
> "Q5U4D8-1","RefSeq","NP_808538.1","25999427","S. typhimurium infection inhibits intestinal biotin uptake by SLC5A6, and that the inhibition is mediated via the action of proinflammatory cytokines."
> "Q5U4D8-1","RefSeq","NP_808538.1","23104561","These studies also provide evidence for a casual association between SMVT function and normal intestinal health"
17453a23503,23504
> "Q99MV1-1","RefSeq","NP_113564.2","17038506","Targeted mutation in Tudor domain containing 1/mouse tudor repeat 1 (Tdrd1/Mtr-1), a tudor-related gene in mice, leads to male sterility because of postnatal spermatogenic defects"
> "Q99MV1-1","RefSeq","NP_113564.2","14550528","Isolated Mouse tudor repeat-1 (Mtr-1) which encodes a MYND domain and four copies of the tudor domain. Mtr-1 is expressed in germ-line cells and is most abundant in fetal prospermatogonia and postnatal primary spermatocytes."
17466a23518
> "Q7TNB4-1","RefSeq","NP_082017.2","19116663","Maestro is dispensable for normal male sexual development and fertility in laboratory mice"
17481a23534
> "Q9EPX5-1","RefSeq","NP_038939.2","26999371","Study investigated the role of FBXL12 in T-cell development by examination of FBXL12-null mice, finding that the FBXL12-ALDH3 axis plays a key role in regulation of the positive selection of T cells."
17484a23538
> "Q8R0J1-1","RefSeq","NP_941006.2","20634288","GIPC1-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion."
17485a23540
> "Q9CWV1-1","RefSeq","NP_079952.2","22771120","MCM8 and MCM9 form a complex and that they coregulate their stability."
17493a23549,23553
> "Q61542-1","RefSeq","NP_067522.1","30322615","The results suggested that MLN64 played a critical role in the meditation of osteoclastic differentiation, and its suppression alleviated diabetic osteoporosis in streptozotocin-induced mice."
> "Q61542-1","RefSeq","NP_067522.1","29908180","Stard3 is an essential factor for the 3T3-L1 cells' differentiation"
> "Q61542-1","RefSeq","NP_067522.1","27679500","The role of endosomal cholesterol trafficking protein, StAR-related lipid transfer domain 3 (StarD3/MLN64), in BRIN-BD11 insulinoma cells."
> "Q61542-1","RefSeq","NP_067522.1","19965586","A transport pathway for endosomal cholesterol to mitochondria that requires MLN64, but not NPC1"
> "Q9JIY7-1","RefSeq","NP_075944.1","25057902","Results show that Nat8 is down-regulated in liver ischemia/reperfusion injury and its upregulation prevents it suggesting its protective effect against liver injuries. Publication Status: Online-Only"
17502a23563
> "P63277-4","RefSeq","NP_033796.1","29337060","The maxillary incisors of Amelx-/- mutants indicated the increase of the frequency and number of labial grooves with aging."
17509,17510c23570,23574
< "Q3UTY6-1","RefSeq","NP_001035516.2","21880733","ADAMTSL6beta has a role in fibrillin-1 microfibril formation"
< "Q3UTY6-1","RefSeq","NP_001035516.2","19940141","Results indicated that ADAMTSL-6 is a novel microfibril-associated protein that binds directly to fibrillin-1 and promotes fibrillin-1 matrix assembly."
---
> "Q60803-1","RefSeq","NP_035762.2","31243287","TRAF3 positively regulates mesenchymal progenitor cells (MPC) differentiation into osteoblasts. TRAF3 deletion in MPCs activated NF-kappaB RelA and RelB to promote RANKL expression and enhance bone destruction. Publication Status: Online-Only"
> "Q60803-1","RefSeq","NP_035762.2","30579117","The overexpression of TRAF3 attenuated the proinflammatory effects of USP25 knockdown in tolerized Kupffer cells."
> "Q60803-1","RefSeq","NP_035762.2","30553450","IL-17A modulates apoptosis of osteoclast precursors through Beclin1-autophagy-TRAF3 signaling pathway, thereby influencing osteoclastogenesis."
> "Q60803-1","RefSeq","NP_035762.2","30348527","TRAF3 knockdown-reduced apoptosis, inflammatory response and oxidative stress were significantly rescued by promoting JNK activity in LPS and H2O2-cotreated cardiomyocytes."
> "Q60803-1","RefSeq","NP_035762.2","30497068","Rela and Traf3 were both targeted by miR-155-5p."
17517a23582,23594
> "Q9D662-1","RefSeq","NP_062761.2","30065114","These data demonstrate an equivalent function for SEC23A/B, with evolutionary shifts in the transcription program likely accounting for the distinct phenotypes of SEC23A/B deficiency within and across species, a paradigm potentially applicable to other sets of paralogous genes."
> "Q9D662-1","RefSeq","NP_062761.2","28539403","Acinar Sec23b deletion results in induction of ER stress and increased apoptosis in the pancreas, potentially explaining the loss of pancreatic cells and decreased pancreatic weight. These findings demonstrate that SEC23B is required for normal function of pancreatic acinar cells in adult mice."
> "Q9D662-1","RefSeq","NP_062761.2","27297878","SEC23B but not SEC23A is essential for murine pancreatic development. Publication Status: Online-Only"
> "Q9D662-1","RefSeq","NP_062761.2","25071156","Results show that transplantation of SEC23B-deficient hematopoietic stem cells does not result in a hematopoietic stem cells phenotype."
> "Q9D662-1","RefSeq","NP_062761.2","22745161","In SEC23B-deficient embryonic pancreas, defects occur in exocrine and endocrine tissues shortly after differentiation."
> "Q9D4D7-1","RefSeq","NP_081927.1","17928922","MRNA localized in pachytene spermatocytes and round and elongated spermatids; involved in spermatogenesis.  [Cdc50c]"
> "Q80U63-1","RefSeq","NP_573464.2","30136162","That Nuclear receptor subfamily 4 group A member 1 modulated Mfn2 expression via the MAPK-ERK-CREB signaling pathway"
> "Q80U63-1","RefSeq","NP_573464.2","30017354","These results suggest that, as a potential key component of a novel and heretofore unrecognized mechanism of cytoplasmic protein transport, Mfn2 may play a general role in preserving neuromuscular synapses and serve as a common therapeutic target for skeletal muscle atrophy."
> "Q80U63-1","RefSeq","NP_573464.2","15297672","Results suggest that the heptad repeat region (HR2) of mfn1 functions as a mitochondrial tether before fusion"
> "Q91X60-1","RefSeq","NP_659052.1","29785025","These results reveal a beige-selective immune-adipose interaction mediated through CHRNA2 and identify a novel function of nicotinic acetylcholine receptors in energy metabolism."
> "Q91X60-1","RefSeq","NP_659052.1","28507032","The results of this study demonstrated that alpha2* nAChRs influenced hippocampus-dependent learning and memory, as well as nicotine-facilitated CA1 hippocampal synaptic plasticity. Publication Status: Online-Only"
> "Q91X60-1","RefSeq","NP_659052.1","28182735","Chrna2-expressing Martinotti cells selectively target L5 thick-tufted type A pyramidal cells (PCs) but not thin-tufted type B PCs. Publication Status: Online-Only"
> "Q91X60-1","RefSeq","NP_659052.1","26111579","These results demonstrate that nicotine withdrawal enhances neuronal activity within the interpeduncular nucleus and dorsal hippocampus, which is absent in mice null for alpha2-containing nAChRs."
17523,17526d23599
< "Q9R0C8-1","RefSeq","NP_065251.2","30450647","This study highlights Vav3 as a novel regulator of oligodendrocyte maturation and remyelination, suggesting that manipulation of the Vav3-dependent signaling pathway could help to improve myelin repair."
< "Q9R0C8-1","RefSeq","NP_065251.2","29858212","Inactivation of Vav3 in vivo resulted in increased vascular leakage, highlighting its function as a key regulator of barrier stability."
< "Q9R0C8-1","RefSeq","NP_065251.2","15365099","Three Vav proteins (vav1,vav2 and vav3) function specifically in distinct pathways that trigger NK cell cytotoxicity."
< "Q9R0C8-1","RefSeq","NP_065251.2","15249579","Vav1 and Vav3 proteins play an essential role coupling beta2 to Rho GTPases and regulating multiple integrin-induced events important in leukocyte adhesion and phagocytosis."
17535,17538d23607
< "Q9D2Y4-1","RefSeq","NP_001297542.1","30738250","MLKL deficiency prevents inflammatory cytokines production and MAPK signaling activation. Hence, MLKL deficiency inhibits DSS-induced colitis."
< "Q9D2Y4-1","RefSeq","NP_001297542.1","23835476","Neither Mlkl nor Rip3 deficiency provided protection against polymicrobial sepsis-induced animal death in the study of septic shock induced by CLP."
< "Q9D2Y4-1","RefSeq","NP_001297542.1","23612963","The importance of the RIP3-MLKL interaction in the formation of functional necrosomes and suggest that translocation of necrosomes to mitochondria-associated membranes is essential for necroptosis signaling."
< "Q9D2Y4-1","RefSeq","NP_001297542.1","22265413","Findings implicate MLKL as a key mediator of necrosis signaling downstream of the kinase RIP3."
17545a23615
> "Q9QZV9-1","RefSeq","NP_062735.4","18048358","Regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport by ERK map kinases requires TAP-NxT1 binding and the AU-rich element"
17559a23630,23631
> "P42228-1","RefSeq","NP_035617.1","29524223","These findings show a feed-forward mechanism involving STAT4 and T-BET that modulates the outcome of IL-23 signaling in innate lymphoid cells"
> "P42228-1","RefSeq","NP_035617.1","29055004","This study shows that STAT4 regulates the CD8(+) regulatory T cell/T follicular helper cell axis and promotes atherogenesis in insulin-resistant Ldlr(-/-) mice"
17567a23640,23641
> "P23475-1","RefSeq","NP_034377.2","29447383","Our results reveal PARP1 and the Ku70/80 complex as critical DNA double-strand breaks (DSBs) sensors, and suggest that PARP1 may function as an important regulator of the Ku70/80 complex at the DSBs in the S/G2 phase."
> "P23475-1","RefSeq","NP_034377.2","28759779","Ku70 is epistatic with XLF and DNA-PKcs and support a model in which inactivation of Ku70 allows DNA lesions to become accessible to alternative DNA repair pathways (other than Classical Non-Homologous End-Joining (C-NHEJ))."
17570a23645,23649
> "H7BX60-1","RefSeq","NP_082646.1","30082315","Results establish that shelterin represses ATR with a tethered ssDNA-binding domain that excludes RPA from the 3' overhang and also reveal an unexpected effect of CST on the ability of POT1b to repress ATR"
> "H7BX60-1","RefSeq","NP_082646.1","25056954","Demonstrated that cells expressing TIN2DeltaTPP1 instead of wild-type TIN2 phenocopy the POT1a,b knockout setting without showing additional phenotypes"
> "H7BX60-1","RefSeq","NP_082646.1","17948054","Tripeptidyl peptidase I (Tpp1) confers telomere end protection by recruiting Pot1a and Pot1b to telomeres."
> "H7BX60-1","RefSeq","NP_082646.1","17632522","Tpp1 is required for the protective function of Pot1 proteins. Erratum:[Nat Struct Mol Biol. 2009 May;16(5):572]"
> "H7BX60-1","RefSeq","NP_082646.1","17053789","ShRNA mediated depletion of endogenous Pot1b in Pot1a deficient cells resulted in increased chromosomal aberrations"
17572a23652,23653
> "Q8R5C8-1","RefSeq","NP_001334405.1","26845565","This study identifies the BS69 C-terminal domains as an inhibitor of EBNA2. Publication Status: Online-Only"
> "Q8R5C8-1","RefSeq","NP_001334405.1","16565076","BS69 has roles in gene repression and chromatin remodeling"
17589a23671
> "Q64385-1","RefSeq","NP_034679.1","28735867","Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome."
17611a23694,23696
> "Q9QZH6-1","RefSeq","NP_036159.1","29514094","These results demonstrate a key role of ECSIT in complex I function, mitochondrial reactive oxygen species production, and mitophagy-dependent mitochondrial quality control."
> "Q9QZH6-1","RefSeq","NP_036159.1","29291352","ECSIT-T419C knock-in mice showed higher peritoneal NADPH oxidase activity than mice with wild-type ECSIT in response to LPS. ECSIT-T419C-transfected ENKTL cell lines produced tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, which induced macrophage activation and massive cytokine secretion in cell culture and mouse xenografts."
> "Q9QZH6-1","RefSeq","NP_036159.1","14633973","Functions as an essential component in two important signal transduction pathways and establishes a novel role for Ecsit as a cofactor for Smad proteins in the bone morphogenetic protein signaling pathway"
17627,17628d23711
< "Q8R035-1","RefSeq","NP_001334574.1","27029019","Because ICT1 is essential in human cells, these results suggest that ribosome rescue activity in mitochondria is required in humans Publication Status: Online-Only"
< "Q8R035-1","RefSeq","NP_001334574.1","20869366","Solution structure of the catalytic domain of the ICT1 protein that lacks an N-terminal mitochondrial targeting signal and an unstructured C-terminal basic-residue-rich extension"
17633a23717
> "Q8BXP5-1","RefSeq","NP_659039.1","20026326","Studies isolated Panky/Ankrd33, a gene encoding an ankyrin repeat-containing protein and that PANKY inhibited the DNA-binding activity of CRX."
17642a23727,23739
> "Q5G5D5-1","RefSeq","NP_001013773.1","28935154","Serum lipocalin-2 concentrations and mortality of severe traumatic brain injury"
> "Q5G5D5-1","RefSeq","NP_001013773.1","28679758","Knocking down Ly6e greatly reduced SynA-induced cell fusion, thus suggesting that Ly6e is the sole receptor for SynA in vivo. Publication Status: Online-Only"
> "Q5G5D5-1","RefSeq","NP_001013773.1","18077339","Findings show that in both humans and mice, one of the two syncytins (human syncytin-2 and mouse syncytin-B) is immunosuppressive and, rather unexpectedly, the other (human syncytin-1 and mouse syncytin-A) is not"
> "Q5G5D5-1","RefSeq","NP_001013773.1","17105734","Syncytin-A is a candidate regulator of fusion from retroviral origin"
> "Q5G5D5-1","RefSeq","NP_001013773.1","17762178","Present evidence in support of the direct role for syncytin-A in mouse trophoblast stem cell fusion and differentiation involved in placental dev"
> "Q5G5D5-1","RefSeq","NP_001013773.1","15644441","Critical role of syncytin-A and -B in syncytiotrophoblast formation, a situation where two pairs of endogenous retroviruses, independently acquired by primate and rodent lineages, were selected for a convergent physiological role. (syncytin-A, syncytin-B)"
> "Q60819-1","RefSeq","NP_598597.1","30926899","Data reveal a critical function of Shp-2 as a molecular nexus bridging acute IL-15 signaling with downstream metabolic burst and NK cell expansion. Publication Status: Online-Only"
> "Q60819-1","RefSeq","NP_598597.1","29676596","IL-15 is a particularly important regulator of natural killer development, differentiation, homeostasis, and activation."
> "Q9WUB7-1","RefSeq","NP_077723.3","29326302","Our study provides in vivo evidence that, in response to a low-potassium diet, ClC-K and barttin play important roles in the activation of the WNK4-SPAK-NCC cascade and blood pressure regulation. Publication Status: Online-Only"
> "Q9WUB7-1","RefSeq","NP_077723.3","23791703","Molecular substrate of a chloride channel previously detected in the mouse thick ascending limb"
> "Q6PCM1-1","RefSeq","NP_766589.1","29674659","JMJD1A mediates two major signaling pathways, namely, beta-adrenergic receptor and peroxisome proliferator-activated receptor-gamma (PPARgamma) activation, via PRDM16-PPARgamma-P-JMJD1A complex for beige adipogenesis. Publication Status: Online-Only"
> "Q6PCM1-1","RefSeq","NP_766589.1","29526734","JMJD1A and JMJD1B, in combination, ensure early embryogenesis and embryonic stem cell viability by establishing the correct Histone 3 lysine 9 methylated epigenome."
> "Q6PCM1-1","RefSeq","NP_766589.1","16619273","TSGA may modulate the function of ER71 and thereby affect spermatogenesis as well as embryonic development"
17643a23741,23744
> "O08573-1","RefSeq","NP_034838.2","30120235","Galectin-9 mediates the close association of IgM and CD22. Publication Status: Online-Only"
> "O08573-1","RefSeq","NP_034838.2","29844236","The authors found that Salmonella Typhimurium infection augmented Tim-3 expression on intestinal lamina propria CD4(+) T cells and enhanced galectin-9 expression on F4/80(+) CD11b(+) macrophages. Publication Status: Online-Only"
> "O08573-1","RefSeq","NP_034838.2","29611821","Gal-9 inhibits the phenotypic maturation of pDCs and B cells and abrogates their ability to mount cytokine responses to TLR7/TLR9 ligands."
> "O08573-1","RefSeq","NP_034838.2","29651447","This study shows that impaired Gal-9 dysregulates the blood mononuclear cells-induced Th1/Th2 imbalance in abortion-prone matings Publication Status: Online-Only"
17649a23751,23758
> "P97350-1","RefSeq","NP_062619.1","30949721","Pkp1 regulates desmoglein membrane availability, whereas Pkp1 but not Pkp3 is required for desmoglein 3 clustering."
> "P97350-1","RefSeq","NP_062619.1","30841437","PKP1 was identified as a new potential tumor suppressor in human melanoma."
> "P27656-1","RefSeq","NP_032306.2","27172975","The LIGHT (Tumour necrosis factor ligand superfamily member 14, TNFSF14)/Lymphotoxin beta-Receptor(LTbeta-R) pathway, which is involved in T-cell and macrophage activation, was diminished in plasma and in apoE-/-Irs2+/-HL-/- atheromas."
> "P27656-1","RefSeq","NP_032306.2","26423094","Hepatic lipase KO mice had dyslipidemia including hypercholesterolemia, hypertriglyceridemia and increased non-esterified fatty acid levels. Also glucose intolerance, pancreatic and hepatic inflammation and steatosis."
> "P55099-1","RefSeq","NP_033338.2","30769143","Study in mice provide evidence for Tac2 as a strong candidate gene who likely plays a role in hippocampal stress processing and neural plasticity."
> "P55099-1","RefSeq","NP_033338.2","30382693","Gene expression in the hypothalamus did not significantly change after 90 or 180 min restraint stress Publication Status: Online-Only"
> "P55099-1","RefSeq","NP_033338.2","16160861","Incongruent pattern of neurokinin B expression in rat and mouse brains."
> "P55099-1","RefSeq","NP_033338.2","12773411","Preprotachykinin (PPT)-B genes are expressed in uterine cells, oocytes, ovaries and embryos from mice, and may play a role in female reproductive function."
17651a23761
> "O54834-1","RefSeq","NP_848869.1","11668396","Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice"
17653a23764,23769
> "Q8BHB0-1","RefSeq","NP_766317.1","30391544","Nod1-mediated lipolysis promoted accumulation of DAG, which engaged PKCdelta and IRAK1/4 to augment inflammation in 3T3-L1 adipocytes."
> "Q8BHB0-1","RefSeq","NP_766317.1","29728425","Our studies establish the miR-146a/NOD1 axis as a key determinant of gammadelta T cell effector functions and plasticity."
> "Q8BHB0-1","RefSeq","NP_766317.1","29450586","The absence of Nod1 does not impair the recruitment of neutrophils in response to P. aeruginosa"
> "Q8BHB0-1","RefSeq","NP_766317.1","29392836","Nod1(+/+) mice with chronic H. pylori infection exhibited significantly increased gastric IL-33 and splenic IL-13 responses, but decreased IFN-gamma responses, when compared with Nod1(-/-) animals. Collectively, our data identify NOD1 as an important regulator of mucosal IL-33 responses in H. pylori infection. We suggest that NOD1 may play a role in protection against excessive inflammation."
> "Q8BHB0-1","RefSeq","NP_766317.1","28652394","Results show that the simultaneous absence of Nod1 and Nod2 is associated with accelerated T cell death upon alloantigen encounter, suggesting these proteins might provide new targets to ameliorate T cell responses in a variety of inflammatory states, including those associated with bone marrow or solid organ transplantation."
> "Q8BHB0-1","RefSeq","NP_766317.1","12796777","NOD1 mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan."
17673a23790,23795
> "Q9CQB5-1","RefSeq","NP_080178.1","29166610","CISD2 haploinsufficiency disrupts calcium homeostasis, causing ER stress and subsequent nonalcoholic fatty liver disease and nonalcoholic steatohepatitis"
> "Q9CQB5-1","RefSeq","NP_080178.1","27392289","These results suggest that the thermosensitive FA-loaded hydrogel could rescue Cisd2(-/-) CM from oxidative stress-induced damage and may have potential applications in the future treatment of CVD."
> "Q9CQB5-1","RefSeq","NP_080178.1","26230298","Cisd2 deficiency impairs the activation of Wnt/beta-catenin signaling"
> "Q9CQB5-1","RefSeq","NP_080178.1","22343142","NAF-1, a BCL-2-associated autophagy regulator, is required for homeostatic maintenance of skeletal muscle"
> "Q9CQB5-1","RefSeq","NP_080178.1","20649540","CISD2 has a role in lifespan control and disease [review] Review article"
> "Q9CQB5-1","RefSeq","NP_080178.1","19451219","Cisd2 deficiency in mice causes mitochondrial breakdown and dysfunction accompanied by autophagic cell death, and these precede nerve and muscle degeneration; together, they lead to a panel of phenotypic features suggestive of premature aging"
17676a23799,23800
> "P70387-1","RefSeq","NP_034554.2","30427936","The osteoporotic phenotype was only evident in Hfe-KO mice fed the iron-enriched diet. This appeared to result from an imbalance between bone formation and bone resorption driven by iron toxicity associated to Hfe-KO and confirmed by a decrease in bone microarchitecture parameters (identified by micro-CT) and osteoblast number Erratum:[PLoS One. 2019 Apr 29;14(4):e0216377. PMID: 31034507] Publication Status: Online-Only"
> "P70387-1","RefSeq","NP_034554.2","29315562","The HFE genotype impacts the expression of tyrosine hydroxylase in the substantia nigra, the gut microbiome and the response to paraquat providing additional support that the HFE genotype is a disease modifier for Parkinson's disease"
17680a23805,23807
> "P47915-1","RefSeq","NP_033108.1","23118343","Depletion of Rpl29 using RNA interference inhibited VEGF-induced aortic ring sprouting"
> "P47915-1","RefSeq","NP_033108.1","20362701","Consistent with the HIP/RPL29-null bone phenotype, HIP/RPL29-deficient teeth also showed reduced geometric properties accompanied with relative increased mineral densities of both dentin and enamel."
> "P47915-1","RefSeq","NP_033108.1","11803571","Analyzed the expression pattern in the mammary gland especially with respect to luminal epithelial cell growth and differentiation during pregnancy and lactation"
17699a23827,23828
> "E9Q774-1","RefSeq","NP_001333713.1","27402760","Data suggest that membrane-proximal signaling complexes constrained by AKAP220 impact the actin barrier dynamics and AQP2 trafficking to ensure water homeostasis."
> "E9Q774-1","RefSeq","NP_001333713.1","21460214","IQGAP2 and AKAP220 act synergistically to sustain PKA-mediated recruitment of effectors such as Rac GTPases that impact the actin cytoskeleton"
17702a23832,23834
> "Q9QX96-1","RefSeq","NP_056587.2","29689621","SALL2 is a negative regulator of cell proliferation, an effect mediated in part by repression of G1-S cyclins' expression."
> "Q9QX96-1","RefSeq","NP_056587.2","26181197","In addition, studies in leukemia Jurkat T cells support the existence of the Sall2/Noxa axis, and the significance of this axis on the apoptotic response to doxorubicin in cancer cells. Publication Status: Online-Only"
> "Q9QX96-1","RefSeq","NP_056587.2","12482961","We have now generated mice lacking Sall2.Mice lacking both Sall1 and Sall2 show kidney phenotypes comparable to those of Sall1 knockout, thereby demonstrating the dispensable roles of Sall2 in embryonic and kidney development"
17703a23836
> "Q9DCH6-1","RefSeq","NP_075361.2","21980954","AWP1 is a novel cofactor of Pex6 involved in the regulation of Pex5 export during peroxisome biogenesis."
17713,17718d23845
< "Q8R2Y0-1","RefSeq","NP_001317993.1","27783937","These findings identify ABHD6 as a regulator of the counter-regulatory responses to major metabolic shifts."
< "Q8R2Y0-1","RefSeq","NP_001317993.1","26997277","Alpha/beta-domain hydrolase-6 suppression averts diet-induced obesity and enhances adipose browning and brown adipose function via PPAR alpha/PPAR gamma activation."
< "Q8R2Y0-1","RefSeq","NP_001317993.1","23806692","FAAH but not monoacyl glycerol lipase exerts important protective actions against 2-arachidonoyl glycerol-induced cellular damage."
< "Q8R2Y0-1","RefSeq","NP_001317993.1","21665953","Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons."
< "Q8R2Y0-1","RefSeq","NP_001317993.1","20657592","ABHD6 is a rate-limiting step of 2-AG signaling"
< "Q8R2Y0-1","RefSeq","NP_001317993.1","18096503","Data reveal that 85% of brain 2-arachidonoylglycerol hydrolase activity can be ascribed to monoacylglycerol lipase(MAGL), and the remaining 15% is catalyzed by ABHD6 and ABHD12."
17722a23850,23852
> "Q9JJG5-1","RefSeq","NP_067347.2","29654510","Data suggest that expression of microRNA-128-3p is down-regulated during adipogenesis; an abundance of microRNA-128-3p appears to down-regulate adipogenesis and up-regulate lipolysis in adipocytes by targeting expression of Pparg (peroxisome proliferator-activated receptor gamma) and Sertad2 (SERTA domain-containing protein-2)."
> "Q9JJG5-1","RefSeq","NP_067347.2","28067333","Study demonstrates a role for TRIP-Br2 in endoplasmic reticulum stress-induced brown adipose tissue (BAT) dysfunction, and inhibiting TRIP-Br2 could be a potential approach for counteracting obesity-induced BAT dysfunction. Publication Status: Online-Only"
> "Q9JJG5-1","RefSeq","NP_067347.2","27109496","Transcription factor GATA3 is responsible for the ER stress-induced TRIP-Br2 expression in visceral fat. Publication Status: Online-Only"
17728a23859
> "P09838-2","RefSeq","NP_033371.2","27311013","Molecular dynamics simulations and structural analysis to decipher functional impact of a twenty residue insert in the ternary complex of mus musculus TdT isoform have been reported. Publication Status: Online-Only"
17731c23862,23875
< "Q8BHN3-1","RefSeq","NP_001280550.1","18648322","Progression of neuropathologic and Behavioral abnormalities in a Pompe disease mouse model (6neo/6neo) that displays many features of the human disease"
---
> "O35638-1","RefSeq","NP_067440.3","12034751","A cohesin complex containing Rad21 and STAG2 cooperates with a STAG3-specific complex to maintain sister chromatid cohesion during the diplotene stage of meiosis"
> "Q9JLJ4-1","RefSeq","NP_062296.1","28377873","Network-based analysis suggests a role for Elovl2 in glucose-induced insulin secretion.  Elovl2 silencing decreased glucose-stimulated insulin secretion in mouse and human beta cell lines. Publication Status: Online-Only"
> "Q9JLJ4-1","RefSeq","NP_062296.1","27864326","The proportion of DHA in the liver and serum of the Elovl2(-/-) offspring was significantly lower than in the Elovl2(+/+) offspring. Remarkably, the DHA level in the Elovl2(+/-) offspring nursed by DHA-free-fed Elovl2(-/-) mothers was almost as high as in +/+ pups delivered by +/+ mothers, suggesting that endogenous synthesis in the offspring can compensate for maternal DHA deficiency."
> "Q9JLJ4-1","RefSeq","NP_062296.1","24489111","Liver docosahexanoic acid synthesis (via ELOVL2), in addition to controlling de novo lipogenesis, also regulates lipid storage and fat mass expansion in an SREBP-1c-independent fashion."
> "O54931-1","RefSeq","NP_001291473.1","26432469","Knocking down akap2 expression remarkably decreased tumorigenicity and metastatic ability of prostate cancer cells. AKAP2 may serve as a critical component of Calcitonin receptor-mediated oncogenic actions."
> "O54931-1","RefSeq","NP_001291473.1","22095752","The AKAP2 protein is direct phosphorylation within a regulatory region of aquaporin-0 to modulate water permeability."
> "P55088-1","RefSeq","NP_033830.2","30809535","AQP-1 was decreased in renal papilla and AQP-4 expressions were increased in proximal tubule by suppressing renin activity or supplement of Vitamin D analogue. After injecting renin into the lateral ventricle of the 1alpha(OH)ase knockout mice, the renin expression level was decreased in the kidney, followed by the decrease of AQP-1 in renal papilla and increase of AQP-4 in proximal tubule Publication Status: Online-Only"
> "P55088-1","RefSeq","NP_033830.2","20877385","Results demonstrate that apparent diffusion coefficient values in normal brain are modulated by astrocytic AQP4; suggest imaging changes seen in acute neurologic disorders such as stroke and trauma are in part due to changes in tissue AQP4 levels"
> "Q8VIK5-1","RefSeq","NP_690012.2","29577896","Expression of the myogenic markers Desmin, MYOG, and MYH2 revealed that PEAR1 positively regulated C2C12 cell differentiation"
> "Q8VIK5-1","RefSeq","NP_690012.2","26156496","Platelet endothelial aggregation receptor-1: a novel modifier of neoangiogenesis."
> "Q8VIK5-1","RefSeq","NP_690012.2","24743597","Jedi-1 signals through recruitment of GULP, which promotes phagocytosis through a noncanonical phosphoclathrin-dependent mechanism."
> "Q8VIK5-1","RefSeq","NP_690012.2","22993420","These results indicated that both Jedi-1 and MEGF10 can mediate phagocytosis independently through the recruitment of Syk."
> "Q8VIK5-1","RefSeq","NP_690012.2","19915564","A cellular and molecular mechanism by which neuronal corpses are culled during dorsal root ganglia development involves Jedi protein"
> "Q8VIK5-1","RefSeq","NP_690012.2","17226770","Jedi is involved in the fine regulation of the early stages of hematopoietic differentiation, presumably through the Notch signaling pathway."
17733a23878
> "P63157-1","RefSeq","NP_062319.1","29413750","Data demonstrate the essential role of Barhl1 during hair cell development and provide a basis for the treatment of Barhl1 mutation-based deafness. Erratum:[Int J Biochem Cell Biol. 2018 Feb 21;:. PMID: 29477628]"
17735a23881,23882
> "P04247-1","RefSeq","NP_038621.2","28862673","Inhibition of mammalian target of rapamycin (mTOR) activation using rapamycin restored Mb mRNA expression to control levels. Lipid supplementation had no effect on Mb gene expression. Thus, IGF-1-induced anabolic signaling can be a strategy to improve muscle size under mild hypoxia, but lowers Mb gene expression Publication Status: Online-Only"
> "P04247-1","RefSeq","NP_038621.2","28230173","The authors here unravel a novel role of cardiac myoglobin in governing fatty acid metabolism to ensure the physiological energy production through beta-oxidation, preventing myocardial lipid accumulation and preserving cardiac functions. Publication Status: Online-Only"
17736a23884,23885
> "Q9D1C8-1","RefSeq","NP_080118.1","25098452","CIIA attenuates neurotoxicity caused by OGD/R through inhibiting ASK1-dependent signaling events."
> "Q9D1C8-1","RefSeq","NP_080118.1","22042618","CIIA functions as a molecular switch for the GEF activity of SOS1, directing this activity toward Rac1."
17748c23897
< "Q6NXH3-1","RefSeq","NP_001116435.1","14612417","Binds specifically to the adenosine deaminase gene promoter"
---
> "Q8R3L0-1","RefSeq","NP_778167.1","18057121","These experiments suggest that MMgT proteins may provide regulated pathways for Mg(2+) transport in the Golgi and post-Golgi organelles of epithelium-derived cells.(MMgT1 PROTEIN, MOUSE)"
17750a23900,23905
> "Q3U0X6-1","RefSeq","NP_001153155.1","29846698","Zfp217 and Zfp516 facilitate Ctbp2-mediated repression on active embryonic stem cell genes during differentiation."
> "Q3U0X6-1","RefSeq","NP_001153155.1","28653987","Three microRNAs (miR-503-5p, miR-135a-5p and miR-19a-3p) which target Zfp217 were found to suppress the process of adipogenesis. This is the first report showing that Zfp217 has the capacity to regulate adipogenesis. Publication Status: Online-Only"
> "Q3U0X6-1","RefSeq","NP_001153155.1","27519282","ZFP217 regulates N6-methyladenosine mRNA deposition in embryonic stem cells thus contributing to tumorigenesis by dysregulating gene expression programs."
> "Q3U0X6-1","RefSeq","NP_001153155.1","26526723","ZFP217 has a role in regulating pluripotency and reprogramming and is coordinated by m(6)A mRNA methylation"
> "Q3U0X6-1","RefSeq","NP_001153155.1","20661224","Results show that ZNF217 regulates ErbB3 expression"
> "Q3U0X6-1","RefSeq","NP_001153155.1","16940172","These results identify a new CtBP interaction motif and establish ZNF217 as a transcriptional repressor protein that functions, at least in part, by associating with CtBP."
17752a23908
> "Q9JJA4-1","RefSeq","NP_067287.1","11827460","Amino-terminal similarity to Notchless WD repeat protein. May function in the modulation of Notch signaling activity."
17757,17759c23913,23919
< "P51125-1","RefSeq","NP_001288082.1","30190286","These results suggest that CAST and ELKS work in concert to promote retinal synapse formation, transmission, and maintenance."
< "P51125-1","RefSeq","NP_001288082.1","29355642","The knockdown of CAST in mutant huntingtin-expressing cells and the knockout of the Cast gene in a knock-in mouse model of HD resulted in a worsening of the molecular HD-related hallmarks including elevated formation of huntingtin fragments and increased amount of respective aggregates"
< "P51125-1","RefSeq","NP_001288082.1","29089532","Mice that were either wild type (WT) or overexpressing calpastatin (CAST Tg), the endogenous inhibitor of calpains were fed with high (60% kcal) fat diet for 16 weeks. CAST overexpression significantly reduced adipocyte apoptosis, adipose tissue collagen and macrophage accumulation; and significantly attenuated obesity-induced inflammatory responses in adipose tissue. Publication Status: Online-Only"
---
> "Q91ZR3-1","RefSeq","NP_660133.2","30413092","These results suggest that CREBZF might play a proapoptotic role in cell apoptosis in granulosa cells, possibly by regulating the ERK1/2 and mTOR signaling pathways Publication Status: Online-Only"
> "Q91ZR3-1","RefSeq","NP_660133.2","26340929","SMILE is an insulin-inducible corepressor that suppresses hepatic gluconeogenesis."
> "Q91ZR3-1","RefSeq","NP_660133.2","25896661","Small heterodimer partner-interacting leucine zipper protein inhibits adipogenesis by regulating peroxisome proliferator-activated receptor gamma activity."
> "Q91ZR3-1","RefSeq","NP_660133.2","24389415","Taken together, these findings demonstrate that SMILE negatively regulates osteocalcin via a direct interaction with RUNX2"
> "Q91ZR3-1","RefSeq","NP_660133.2","24325733","CREBZF is involved in implantation and is up-regulated by oestrogen. Publication Status: Online-Only"
> "Q91ZR3-1","RefSeq","NP_660133.2","21956870","Smile is a novel gene specifying both bronchial smooth muscle and lung alveolar myofibroblast lineages, contributing to our understanding of the biological control of the development of these cells."
> "Q91ZR3-1","RefSeq","NP_660133.2","21994947","The curcumin/LKB1/AMPK/SMILE/PGC1alpha pathway differentially regulates ER stress-mediated gene transcription"
17763a23924,23927
> "Q91WW4-1","RefSeq","NP_694741.2","27612496","Ultra-high doses did not influence the ACE2/AT2R/Mas axis and promoted renal injury with increased renal ERK1/2 activation and exaggerated fibronectin expression in db/db mice. Our study demonstrates dose-related effects of candesartan in diabetic nephropathy: intermediate-high dose candesartan is renoprotective, whereas ultra-high dose candesartan induces renal damage. Publication Status: Online-Only"
> "Q91WW4-1","RefSeq","NP_694741.2","20724664","Data suggest that members of the Mrgpr family, in particular MrgprC11, may constitute an endogenous inhibitory mechanism for regulating persistent pain in mice"
> "Q91WW4-1","RefSeq","NP_694741.2","18025412","Mas deficiency in FVB/N mice leads to dramatic changes in glucose and lipid metabolisms, inducing a metabolic syndrome-like state."
> "Q91WW4-1","RefSeq","NP_694741.2","12829792","Deletion of the Mas protooncogene abolishes the binding of Ang-(1-7) to mouse kidneys. Mas is a functional receptor for Ang-(1-7)"
17771c23935,23936
< "Q9CQ89-1","RefSeq","NP_080583.3","19645739","An N-terminal CutA domain actually drives AChE into the endoplasmic reticulum and allows its secretion"
---
> "Q8BZQ2-1","RefSeq","NP_084485.1","17616516","CRISPLD2 is expressed in the mandible, palate and nasopharynx regions during craniofacial development at E13.5-E17.5, respectively. Altogether, these data suggest that genetic variation in CRISPLD2 has a role in the etiology of NSCLP. Erratum:[Hum Mol Genet. 2008 Apr 1;17(7):1061. Arco-Burgos, Mauricio [corrected to Arcos-Burgos, Mauricio]]"
> "P80205-1","RefSeq","NP_035153.1","29273633","This study demonstrates that Otx1 is one of the key elements regulating cortical neurogenesis, and a loss-of-function in Otx1 may contribute to the overproduction of astrocytes in vivo."
17784a23950
> "Q922W5-1","RefSeq","NP_659044.1","27939882","Susceptibility to experimental pancreatitis is determined by strain and model differences with Clusterin and Pycr1 alterations"
17796a23963,23967
> "Q8BKE5-1","RefSeq","NP_001243074.1","30204892","Rad54/Rad54B deficiency may impact on the DNA integrity of developing mouse gametes."
> "Q5U5Q9-1","RefSeq","NP_035437.1","22896338","Data indicate that RAP80-deficiency promotes genomic instability and causes an increase in cancer risk consistent with the concept that RAP80 exhibits a tumor suppressor function."
> "Q5U5Q9-1","RefSeq","NP_035437.1","22689573","A model in which SUMO and Ub modification is coordinated to recruit Rap80 and BRCA1 to DNA damage sites."
> "Q5U5Q9-1","RefSeq","NP_035437.1","22539352","Mechanistically, loss of RAP80 suppresses recruitment of the BRCA1-A complex to DNA damage sites and abrogates the DNA damage repair process at DNA damage sites."
> "Q5U5Q9-1","RefSeq","NP_035437.1","19536136","Both ubiquitin-interacting motif 1(UIM1) and UIM2 of RAP80 recognize an Ile 44-centered hydrophobic patch on ubiquitin but neither UIM interacts with the Lys 63-linked isopeptide bond. [RAP80]"
17799,17800d23969
< "Q80V23-1","RefSeq","NP_001333578.1","25032857","The overexpression of Zfp637 markedly increases mTERT expression and telomerase activity, maintains telomere length, and inhibits H2O2 and D-galactose-induced senescence. Publication Status: Online-Only"
< "Q80V23-1","RefSeq","NP_001333578.1","20235149","Results suggest that Zfp637 inhibits muscle differentiation through a defect in the cell cycle exit by potentially regulating mTERT expression in C2C12 myoblasts"
17803a23973,23977
> "Q80YR7-1","RefSeq","NP_780763.3","21502314","Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1)."
> "Q80YR7-1","RefSeq","NP_780763.3","20081369","Rad9A-mediated Claspin localization is a vital step during checkpoint activation."
> "Q7TN75-1","RefSeq","NP_570947.2","17942406","The ORF1-2 protein of PEG10, synthesized utilizing the most efficient -1 frameshift mechanism yet documented in vivo, will have an essential function that is intrinsic to the importance of PEG10 in mammals"
> "Q7TN75-1","RefSeq","NP_570947.2","16341224","Peg10 gene is imprinted, with preferential expression from the paternal allele, and its deletion results in early embryonic lethality."
> "Q7TN75-1","RefSeq","NP_570947.2","15767280","Characterization of a RNA pseudoknot as a frameshift signal for Edr programmed -1 ribosomal frameshifting. GeneRIF: Programmed -1 ribosomal frameshifting in mouse and human Peg10 genes. Publication Status: Online-Only"
17816,17817c23990,23991
< "Q9JJ43-1","RefSeq","NP_067452.2","30318414","Rbfox1 is a regulator in the development of cortical interneuron-subtype-specific efferent connectivity."
< "Q9JJ43-1","RefSeq","NP_067452.2","30001398","Rbfox1 is expressed in all retinal ganglion cells types and in certain types of amacrine cells in the ganglion cell and inner nuclear layer. In the developing retina, Rbfox1 is present as early as E12. Although no morphological abnormalities were observed in the retinas of adult Rbfox1 KO mice 2 months after downregulation, these animals have an evident deficiency in depth perception. Publication Status: Online-Only"
---
> "Q80U28-1","RefSeq","NP_663502.3","24379354","These findings indicated that IG20/MADD plays a critical role in glucose-induced insulin release from beta-cells and that its functional disruption can cause type 2 diabetes."
> "Q80U28-1","RefSeq","NP_663502.3","12388783","Role of Rab3 GEP in regulating neurotransmitter release in autapses of mouse hippocampal neurons in culture"
17824a23999,24002
> "Q9JHE3-1","RefSeq","NP_061300.1","26747710","These results suggest that neutral ceramidase is a mediator of necroptosis and might be a novel therapeutic target for protection from ischaemic injury."
> "Q9JHE3-1","RefSeq","NP_061300.1","24659784","Knocking down NCDase reduced sphingosine accumulation in mitochondria and preserved COX activity after the brain injury."
> "Q9JHE3-1","RefSeq","NP_061300.1","22940715","Neutral ceramidase deficiency increases inflammation in a mouse model of inflammatory bowel disease."
> "Q9JHE3-1","RefSeq","NP_061300.1","12435403","Molecular cloning of the mouse neutral ceramidase gene and its promoter analysis"
17832a24011,24013
> "Q8CHY6-1","RefSeq","NP_001106817.1","30122475","It validates a distinct molecular axis, Gatad2a-Chd4-Mbd3, within Mbd3/NuRD as being critical for blocking reestablishment of naive pluripotency and further highlight signaling-dependent and post-translational modifications of Mbd3/NuRD that influence its interactions and assembly."
> "Q8CHY6-1","RefSeq","NP_001106817.1","28193828","Our data demonstrate that p66a may physically interact with STAT3 to suppress its activity through posttranslational modification, which reveals a novel regulatory mechanism controlling STAT3 activation during myeloid cell differentiation."
> "Q91WF3-1","RefSeq","NP_536683.1","18388192","SF1 and SP1 contribute to Adcy4 promoter activity via interation with conserved region situated 19 bp upstream of the major transcription start site."
17835,17836d24015
< "P40224-2","RefSeq","NP_038683.1","30898705","Study indicated that the up-regulated expression of CXCL12 in IFN-gamma induced abortion mouse uteri was not directly the responding of the administration of IFN-gamma. The up-regulated expression of CXCL12 in the later stage of aborted mouse uteri played an anti-inflammatory role that involves in the process of endometrial restoration after abortion."
< "P40224-2","RefSeq","NP_038683.1","30870116","Concluded that SDF-1/CXCR4 pathway improved diabetic retinopathy possibly by increasing cell viability"
17846c24025,24026
< "Q6GYP7-1","RefSeq","NP_001106185.1","12200424","Interacts with transcription factor E12 in developing forebrain"
---
> "Q9WVD5-1","RefSeq","NP_851842.1","19372376","Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~55%."
> "P97378-1","RefSeq","NP_032380.1","29896198","Morphological and Functional Characterization of IL-12Rbeta2 Chain on Intestinal Epithelial Cells: Implications for Local and Systemic Immunoregulation. Publication Status: Online-Only"
17848a24029
> "Q9JLB2-1","RefSeq","NP_062525.1","28154200","Pals1 haploinsufficiency in mouse kidneys associated with the upregulation of Hippo pathway target genes and marker genes of TGF-beta signaling, including biomarkers of renal diseases. These findings support a link between apical polarity proteins and renal diseases, especially renal cyst diseases"
17850a24032,24042
> "Q9JIM1-1","RefSeq","NP_075018.1","30408123","Aortas from Slc29a1-null mice respond to hypoxic insult in a manner comparable to wild-type tissues that have been pharmacologically preconditioned with adenosine. The data also support a role for ENT1 in the regulation of the protective effects of adenosine on contractile function in elastic conduit arteries such as thoracic aorta. Publication Status: Online-Only"
> "Q9JIM1-1","RefSeq","NP_075018.1","29804297","The results of this study suggested that binge alcohol consumption-induced down-regulation of ENT1 expression may disrupt sleep homeostasis and cause sleep disturbances"
> "Q9JIM1-1","RefSeq","NP_075018.1","28240653","Calcification of spinal connective tissues in the ENT1 deficient mouse results in a stiffened spine."
> "Q9JIM1-1","RefSeq","NP_075018.1","28069792","Chronic inhibition of ENT1 or by genetic removal of ENT1 enhanced the survival of R6/2 mice. Collectively, adenosine homeostasis and ENT1 expression are altered in Huntington's disease (HD). The inhibition of ENT1 can enhance extracellular adenosine level and be a potential therapeutic approach for treating HD."
> "Q9JIM1-1","RefSeq","NP_075018.1","12062437","PKC delta/epsilon-dependent stimulation of hENT1 transport by a mechanism that may involve activation of transporters at the membrane possibly by post-translational modification of the protein."
> "Q9R007-3","RefSeq","NP_067339.1","29126450","MDL-1 is mainly expressed in atherosclerotic lesional macrophages and increased macrophage MDL-1 expression is associated with early plaque progression and promotes macrophage survival. Publication Status: Online-Only"
> "Q9R007-3","RefSeq","NP_067339.1","28824166","Data show that C-type lectin member 5A (CLEC5A) is needed for optimal reactive oxygen species (ROS) production, neutrophil extracellular traps (NETs) formation and other immune responses to Listeria monocytogenes in mice. Publication Status: Online-Only"
> "Q9R007-3","RefSeq","NP_067339.1","27795434","The results suggest that CLEC5A-mediated enhancement of the inflammatory response in myeloid cells contributes to influenza pathogenicity in vivo and may be considered a therapeutic target in combination with effective antivirals. Publication Status: Online-Only"
> "Q9R007-3","RefSeq","NP_067339.1","27033255","CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis"
> "Q9R007-3","RefSeq","NP_067339.1","26927798","Cigarette smoke-induced macrophage responsiveness is mediated by CLEC5A, and CLEC5A is required for the development of inflammation, proinflammatory cytokine expression, and airspace enlargement."
> "Q9R007-3","RefSeq","NP_067339.1","19074552","MDL-1 plays an important role in immune defense as a result of an innate immunity, which involves neutrophils and macrophages"
17858a24051,24066
> "Q9JKR6-1","RefSeq","NP_067370.3","29718201","The protein but not the mRNA level of ORP150, a nucleotide exchange factor which can substitute for SIL1, was increased in the cerebellum of GSK2606414-treated woozy mice, suggesting that translational recovery promoted the synthesis of this alternative BiP co-factor"
> "Q9JKR6-1","RefSeq","NP_067370.3","27748851","The relative increase in ORP150 mRNA observed in hypoxia, compared with normoxia, may support its cytoprotective role in oxygendeprived conditions"
> "Q9JKR6-1","RefSeq","NP_067370.3","24327659","Here we show that Grp170 can bind directly to a variety of incompletely folded protein substrates in the endoplasmic reticulum, and as expected for a bona fide chaperone, it does not interact with folded secretory proteins."
> "Q9JKR6-1","RefSeq","NP_067370.3","22892132","These results suggest that although ORP150 is protective against bleomycin-induced lung injury, this protein could stimulate bleomycin-induced pulmonary fibrosis by increasing pulmonary levels of TGF-beta1 and myofibroblasts."
> "A2A5N8-1","RefSeq","NP_001074807.1","25849281","L3mbtl1 loss-of-function was associated with significant decreases in depression and and anxiety in some of the behavioral paradigms. Publication Status: Online-Only"
> "A2A5N8-1","RefSeq","NP_001074807.1","20592034","Generation and analysis of mice after disruption of L3MBTL1"
> "Q9JJ69-1","RefSeq","NP_663750.1","29139549","We are investigating the effects of hyperoxia on atrial electrophysiology using whole-cell patch-clamp electrophysiology experiments along with assessment of Kv1.5, Kv4.2, and KChIP2 transcripts and protein profiles using real-time quantitative RT-PCR and Western blotting."
> "Q9JJ69-1","RefSeq","NP_663750.1","28141821","The Kv4.2/KChIP2 interaction in cardiomyocytes is highly dynamic, with a clear KChIP2 gene dosage effect on Kv4 channel surface expression but not on inactivation gating. Publication Status: Online-Only"
> "Q9JJ69-1","RefSeq","NP_663750.1","27736193","KChIP2 expression does not appear to underlie the circadian rhythm in repolarization duration."
> "Q9JJ69-1","RefSeq","NP_663750.1","15878168","KChIP2 contributes to the formation of functional mouse ventricular Kv1.5 channels Erratum:[J Mol Cell Cardiol. 2005 Oct;39(4):723]"
> "Q9JJ69-1","RefSeq","NP_663750.1","15363885","KChIP2 transcripts were highly expressed in layer IV of the cerebral cortex and in striatum and hippocampus, but expressed at low levels in cerebellum."
> "O35732-1","RefSeq","NP_997536.1","29191940","The antagonistic caspase 8-homolog cFLIP is a critical regulator of acute, cholestatic liver injury."
> "O35732-1","RefSeq","NP_997536.1","29099934","Caspase-8 synergizes with the canonical NLRP3 inflammasome pathway to control caspase-1 processing and IL-1beta maturation, providing a regulatory role for caspase-8 in host resistance to in vivo Paracoccidioides brasiliensis infection."
> "O35732-1","RefSeq","NP_997536.1","28850249","Deletion of c-FLIP from CD11b(hi) Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis."
> "O35732-1","RefSeq","NP_997536.1","29107687","In conclusion, our data indicated that miR-150 potentially contributes to the hepatic steatosis and insulin resistance in NAFLD. miR-150/CFLAR pathway may be a new therapeutic strategy against NAFLD."
> "O35732-1","RefSeq","NP_997536.1","28218919","Findings establish CFLAR as a key suppressor of steatohepatitis and indicate that the development of CFLAR-peptide-mimicking drugs and the screening of small-molecular inhibitors that specifically block ASK1 dimerization are new and feasible approaches for NASH treatment. Erratum:[Nat Med. 2017 Oct 6;23 (10 ):1241. PMID: 28985205]"
17869a24078,24081
> "Q7TNC6-1","RefSeq","NP_001155137.1","28885975","Kif26b links Wnt5a-Ror signaling to the control of morphogenetic cell and tissue behaviors in vertebrates and reveal a new role for regulated proteolysis in noncanonical Wnt5a-Ror signal transduction. Publication Status: Online-Only"
> "Q7TNC6-1","RefSeq","NP_001155137.1","26792835","Kif26b, together with Dvl3/Daam1, initiates cell polarity through the control of planar cell polarity-signaling pathway-dependent activation in endothelial cells."
> "Q7TNC6-1","RefSeq","NP_001155137.1","20439720","Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme."
> "Q7TNC6-1","RefSeq","NP_001155137.1","14727108","KIF26B may play a role in embryogenesis, specifically in the development of limbs, face, and somites"
17874a24087
> "Q6B966-1","RefSeq","NP_001002894.2","15590904","Nalp14 transcripts were continuously expressed through the preovulatory stage, but declined when meiotic maturation resumed, and they were markedly diminished by the 2-cell embryo stage."
17881,17885d24093
< "Q920M5-1","RefSeq","NP_624354.1","24523531","These findings demonstrate that Coronin 6 is a critical regulator of AChR clustering at the postsynaptic region of the neuromuscular junction"
< "O70263-1","RefSeq","NP_001153049.1","30185604","Retrograde regulation of mossy fiber axon targeting and terminal maturation via postsynaptic Lnx1."
< "O70263-1","RefSeq","NP_001153049.1","29121065","These findings provide functional insights into the LNX protein family, particularly the neuronal LNX1p70 isoform. Publication Status: Online-Only"
< "O70263-1","RefSeq","NP_001153049.1","19295125","LNX1p80 is involved in the ubiquitylation, endocytosis and lysosomal degradation of claudins, and the turnover of tight junctions is regulated by ubiquitylation."
< "O70263-1","RefSeq","NP_001153049.1","12468544","The PDZ domain-containing protein ligand-of-numb protein-X (LNX) is found in complex with the coxsackievirus and adenovirus receptor (CAR)"
17892,17893d24099
< "Q9QYB5-1","RefSeq","NP_001157571.1","22706708","C-terminal 38 amino acids of gamma-adducin interact with F-actins around the Golgi complex, to facilitate exit of POMC/ACTH vesicles."
< "Q9QYB5-1","RefSeq","NP_001157571.1","19900187","These results strongly suggest coordinated expression and phosphorylation of alpha-, beta-, and gamma-adducins as key mechanism underlying synaptic plasticity, motor coordination performance and learning behaviors."
17902a24109,24116
> "Q8K1B8-1","RefSeq","NP_722490.1","30783087","FERMT3 (kindlin-2) role in proline synthesis and tumor growth.Kindlin-2 regulates proline synthesis through PYCR1. Publication Status: Online-Only"
> "Q8K1B8-1","RefSeq","NP_722490.1","30187863","Kindlin-3 is dispensable for integrin-mediated T cell progenitor adhesion and signalling at low and indispensable at high shear forces. Publication Status: Online-Only"
> "Q8K1B8-1","RefSeq","NP_722490.1","29656482","These results demonstrate that kindlin-3 in neutrophils is involved in modulating reactive oxygen species and extracellular trap signaling"
> "Q8K1B8-1","RefSeq","NP_722490.1","29141864","Expression is markedly suppressed in pathologically activated osteoclasts"
> "Q8K1B8-1","RefSeq","NP_722490.1","19234460","Identify a genetic disease that severely compromises the health of the affected individuals and establish an essential role of KINDLIN-3 in integrin activation in humans"
> "Q8K1B8-1","RefSeq","NP_722490.1","18662549","Stable isotope labeling by amino acids in cell culture confirmed their absence and disclosed a structural defect of the red blood cell membrane skeleton in Kindlin-3-deficient erythrocytes."
> "Q8K1B8-1","RefSeq","NP_722490.1","18278053","Kindlin-3 was identified as a novel and essential element for platelet integrin activation in hemostasis and thrombosis."
> "Q8K1B8-1","RefSeq","NP_722490.1","16876785","The genomic organization, gene expression and subcellular localization of murine Kindlins-1 to -3, is described."
17910a24125,24126
> "P27573-1","RefSeq","NP_032649.2","22457349","L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough."
> "Q9EQG3-1","RefSeq","NP_075024.2","16028229","We conclude that sciellin null mice had no structural anomalies and the transgenic mice did not act as a dominant-negative mutation."
17913a24130,24131
> "Q9CQ92-1","RefSeq","NP_079838.1","30918582","Chronically elevated IL-6 can directly induce DRP-1 and FIS-1 expression through gp130 signaling in cultured myotubes and skeletal muscle. Publication Status: Online-Only"
> "Q9CQ92-1","RefSeq","NP_079838.1","27179109","Our data confirm that FIS1 is a key regulator in pancreatic beta cells, because both glucose-stimulated insulin secretion and mitochondrial dynamics were clearly adapted to precise expression levels of this fission protein."
17919a24138
> "P02831-1","RefSeq","NP_034582.1","29073173","HoxA3 induced upregulation of Jag1 ligand in endothelial cells, which led to cis-inhibition of the Notch pathway, rendering the HE nonresponsive to Notch signals. Publication Status: Online-Only"
17921a24141,24144
> "Q5VCS6-1","RefSeq","NP_001264659.1","29733347","By conditional inactivation of Tdrd5 in postnatal male germ cells (Tdrd5cKO), we show that spermatogenesis is arrested at the round spermatid stage, and the testes of Tdrd5cKO mice are about half the weight of wildtype controls."
> "Q5VCS6-1","RefSeq","NP_001264659.1","29317670","Conditional inactivation of TDRD5 in mouse postnatal germ cells reveals that TDRD5 selectively regulates the production of pachytene piRNAs from abundant piRNA-producing precursors, with little effect on low-abundant piRNAs. Publication Status: Online-Only"
> "Q5VCS6-1","RefSeq","NP_001264659.1","21383078","TDRD5 is a novel component of the intermitochondrial cements (IMCs) and the chromatoid bodies (CBs), which are cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis."
> "Q5VCS6-1","RefSeq","NP_001264659.1","15465492","Tdrd5 expression is restricted to the male germline throughout development to adulthood"
17927a24151,24153
> "Q8C8T7-1","RefSeq","NP_780731.1","25047565","Elfn1 protein increases during postnatal development and localizes to postsynaptic sites of somatostatin-containing interneurons in the hippocampal CA1 stratum oriens and dentate gyrus hilus.Elfn1 recruits mGluR7 to synaptic sites. Publication Status: Online-Only"
> "Q8C8T7-1","RefSeq","NP_780731.1","24312227","Mutation of Elfn1 in mice causes seizures and hyperactivity. Publication Status: Online-Only"
> "Q8C8T7-1","RefSeq","NP_780731.1","23042292","Postsynaptic expression of Elfn1 in oriens-lacunosum moleculare interneurons regulates presynaptic release probability, which confers target-specific synaptic properties to pyramidal cell axons."
17940a24167,24168
> "Q8K394-1","RefSeq","NP_038908.2","28360101","These results suggest that PRIPs are positively involved in the development of follicles via their regulation of LH-LHR signaling and estradiol secretion."
> "Q8K394-1","RefSeq","NP_038908.2","14517301","PLC-L2 is a novel negative regulator of BCR signaling and immune responses"
17945a24174,24177
> "Q8BFW7-1","RefSeq","NP_848780.3","29251630","Cancer-associated fibroblasts regulate endothelial LPP via a calcium-dependent signaling pathway involving microfibrillar-associated protein 5 (MFAP5), focal adhesion kinase (FAK), ERK, and LPP"
> "Q8BFW7-1","RefSeq","NP_848780.3","23447672","Interaction between LPP and alpha-actinin, an actin cross-linking protein, is necessary for TGFbeta-induced migration and invasion of ErbB2-expressing breast cancer cells."
> "Q8BFW7-1","RefSeq","NP_848780.3","22886954","Inactivation of Rho kinase (ROK) with ROK inhibitors significantly inhibited LPP mRNA expression in TGF-beta1-treated SMPCs."
> "Q8BFW7-1","RefSeq","NP_848780.3","12441356","LPP contains specific domains that enable its focal adhesion and nuclear targeting capacity [LIM-containing lipoma-preferred partner [LPP]"
17946a24179,24181
> "Q9JLF1-1","RefSeq","NP_065234.1","22690081","GABRQ plays important roles in hepatocellular carcinoma development and progression"
> "Q6ZPZ3-1","RefSeq","NP_941033.2","30826420","May act as a novel regulator in the progression of SiO2-induced epithelial to mesenchymal transition"
> "Q6ZPZ3-1","RefSeq","NP_941033.2","29401612","Study elucidates a link between SiO2-induced macrophage activation and the circZC3H4 RNA/ZC3H4 pathway, thereby providing novel insight into the potential use of ZC3H4 to develop novel therapeutic strategies for silicosis."
17956,17958d24190
< "Q80XB4-1","RefSeq","NP_032759.3","21998026","Nrarp-deficient embryos and mice exhibit genetic background-dependent defects of the axial skeleton. In Nrarp mutant embryos, the posterior somite compartment was expanded."
< "Q80XB4-1","RefSeq","NP_032759.3","21276443","Results show that chronic NRAP overexpression in the mouse leads to right ventricular cardiomyopathy by 10 months of age."
< "Q80XB4-1","RefSeq","NP_032759.3","12789664","Highly conserved and exclusively expressed in cardiac and skeletal muscle.  Candidate cause for cardiac and skeletal myopathies"
17961a24194,24199
> "P97765-1","RefSeq","NP_001334571.1","21642474","This study established WBP2 as a tyrosine phosphorylation target of estrogen signaling via EGFR crosstalk."
> "O35536-1","RefSeq","NP_033390.1","30254643","TFPI-2 Protects Against Gram-Negative Bacterial Infection. Publication Status: Online-Only"
> "O35536-1","RefSeq","NP_033390.1","27797450","Tissue factor pathway Inhibitor 2 potencies differ between antifibrinolytic agents against human and mouse enzymes plasmin, factor XIa, and kallikrein"
> "O35536-1","RefSeq","NP_033390.1","26603320","A novel mouse model is presented and can be used to investigate the role of TFPI-2 in the process of atherosclerosis."
> "O35536-1","RefSeq","NP_033390.1","23608390","Over-expression of TFPI-2 promotes atherosclerotic plaque stability, which may be related to inhibition of matrix metalloproteinases."
> "O35536-1","RefSeq","NP_033390.1","12921785","Bovine TFPI2 was compared to mouse TFPI2."
17968a24207,24209
> "Q9CY64-1","RefSeq","NP_080954.4","30073505","BVR-A is potential therapeutic target to prevent brain insulin resistance in Alzheimer's disease."
> "Q9CY64-1","RefSeq","NP_080954.4","29195835","This study shows that absence of the biliverdin reductase-a gene is associated with increased endogenous oxidative stress"
> "Q9CY64-1","RefSeq","NP_080954.4","27738106","These findings reveal a novel BVRA-GSKbeta-PPARalpha axis that regulates hepatic lipid metabolism and may provide unique targets for the treatment of non-alcoholic fatty liver disease."
17974,17984c24215
< "P52479-1","RefSeq","NP_001297559.1","30898698","Results show that Mirt2-mediated upregulation of USP10 protein expression can be reversed by silencing USP10 in the hepatocytes. USP10 inhibition could abolish Mirt2 overexpression-induced suppression of glucose production and lipogenesis in hepatocytes."
< "P52479-1","RefSeq","NP_001297559.1","29698567","USP10 inhibits hepatic steatosis, insulin resistance, and inflammation through Sirt6."
< "P52479-1","RefSeq","NP_001297559.1","28852924","USP10 directly interacted with and stabilized PTEN via deubiquitination."
< "P52479-1","RefSeq","NP_001297559.1","27974222","USP10 is an essential deubiquitinase in hematopoiesis and functions by inhibiting apoptosis of hematopoietic stem cells including long-term HSCs."
< "P52479-1","RefSeq","NP_001297559.1","26393420","Thus, modulating the levels of both Huwe1 and USP10 appears to fine-tune the requisite degradation of TBP during myogenesis. Publication Status: Online-Only"
< "P52479-1","RefSeq","NP_001297559.1","18632802","Vasopressin-induced Usp10 deubiquitylates and stabilizes endogenous SNX3 and consequently promotes cell surface expression of ENaC in kidney"
< "Q61985-1","RefSeq","NP_001123922.1","30559296","Nrf1, RUVBL1, and TIP60 proteins were co-recruited to the promoter regions of proteasome genes after proteasome inhibitor treatments."
< "Q61985-1","RefSeq","NP_001123922.1","30287392","The nascent Nrf1alpha (NFE2L1)/TCF11 polypeptide (non-glycosylated) is transiently translocated into the endoplasmic reticulum (ER)."
< "Q61985-1","RefSeq","NP_001123922.1","30268580","Putative ubiquitination of Nrf1 (Nf2el1) is not a prerequisite necessary for involvement of p97 in the client processing."
< "Q61985-1","RefSeq","NP_001123922.1","30135079","Findings reveal novel functions of the NGLY1-NRF1 (Nfe2l1) pathway in mitochondrial homeostasis and inflammation and uncover an unexpected therapeutic strategy using pharmacological activators of NRF2 for treating mitochondrial and immune dysregulation"
< "Q61985-1","RefSeq","NP_001123922.1","29935181","Mechanistic studies revealed that Nfe2l1 deficiency may disturb the expression of lipolytic genes in adipocytes, leading to adipocyte hypertrophy followed by inflammation, pyroptosis, and insulin resistance."
---
> "Q8VHH7-1","RefSeq","NP_612178.2","30366013","Data suggest that type 3 adenylyl cyclase is primarily expressed in the small to medium sized cell bodies and central terminals of CGRP-positive dorsal root ganglion neurons."
17987a24219,24225
> "Q6PDQ2-1","RefSeq","NP_666091.1","31123064","Mi-2beta promotes pre-B-cell differentiation by providing repression capabilities to distinct lineage-specific transcription factor-based regulatory networks."
> "Q6PDQ2-1","RefSeq","NP_666091.1","30409903","Findings reveal that the CHD4/NuRD complex regulates neural differentiation of ESCs by down-regulating p53."
> "Q6PDQ2-1","RefSeq","NP_666091.1","30122475","It validates a distinct molecular axis, Gatad2a-Chd4-Mbd3, within Mbd3/NuRD as being critical for blocking reestablishment of naive pluripotency and further highlight signaling-dependent and post-translational modifications of Mbd3/NuRD that influence its interactions and assembly."
> "Q6PDQ2-1","RefSeq","NP_666091.1","29891665","Direct CHD4-mediated repression of skeletal and smooth muscle myofibril isoforms is required for normal cardiac sarcomere formation, function, and embryonic survival early in gestation. Unique CHD4 binding sites are found in smooth muscle myosin heavy chain, fast skeletal alpha-actin, and the fast skeletal troponin complex genes."
> "Q6PDQ2-1","RefSeq","NP_666091.1","29795351","Results reveal that ADNP, via the recruitment of HP1 and CHD4, regulates the expression of genes that are crucial for maintaining distinct cellular states and assures accurate cell fate decisions upon external cues"
> "Q78JT3-1","RefSeq","NP_079601.1","30063927","In mouse embryos there was no significant upregulation of Haao expression in the developing male external genitalia. Irx6 was expressed in the ectodermal epithelium, demonstrating prominent dorsal ectodermal expression without expression in the ventral ectoderm adjacent to the urethral plate during the same period."
> "Q6NXW6-1","RefSeq","NP_035363.2","15297881","Targeted deletion of an N-terminal part of mRad17, the mouse homolog of the Schizosaccharomyces pombe Rad17 checkpoint clamp-loader component, resulted in embryonic lethality during early/mid-gestation"
17997,17998c24235,24244
< "Q66JX5-1","RefSeq","NP_001183975.1","29982567","We show that Fop mutation perturbs ciliogenesis in vivo and that this leads to the alteration of the Hedgehog signaling pathway. Fop mutation reduces CSs movements and affects pericentriolar material composition, which probably participates to the ciliogenesis defect."
< "Q66JX5-1","RefSeq","NP_001183975.1","12969958","Expression of FOP-FGFR1 in primary bone marrow cells induced by retroviral transduction generates a myeloproliferative disease in mice"
---
> "Q8R0W6-1","RefSeq","NP_075372.1","28580955","Ndfip1 preserves Treg lineage stability and immune homeostasis by preventing the expansion of highly proliferative and metabolically active Treg cells and by preventing pathological secretion of IL-4 from Treg cells Publication Status: Online-Only"
> "Q8R0W6-1","RefSeq","NP_075372.1","28051111","Data support an essential role for Ndfip1 in degrading RORgammaT and suppressing Th17 lineage stability, proinflammatory cytokine production, and pathogenicity. Publication Status: Online-Only"
> "Q8R0W6-1","RefSeq","NP_075372.1","27786273","Findings indicate an important negative regulatory function for Nedd4 ubiquitin protein ligase (Nedd4-2) and Nedd4 family interacting protein 1 (Ndfip1) in IgE-dependent mast cell activity. Publication Status: Online-Only"
> "Q8R0W6-1","RefSeq","NP_075372.1","27088444","Data indicate thar Janus kinase 1 (Jak1) degradation is dependent on Nedd4 family interacting proteins Ndfip1/Ndfip2. Publication Status: Online-Only"
> "Q68FE2-1","RefSeq","NP_001275541.1","29893854","Parkin gene silencing in primary cortical neurons selectively disrupts the vesicular sorting of the autophagy receptor ATG9A, a WASH-dependent retromer cargo. Parkin is not required for dopaminergic neurodegeneration induced by the expression of PD-linked D620N VPS35 in mice, consistent with VPS35 being located downstream of parkin function"
> "Q68FE2-1","RefSeq","NP_001275541.1","29698489","The AP-4 epsilon KO mouse is a suitable model for AP-4 deficiency syndrome, and defective mobilization of ATG9A from the TGN and impaired autophagic degradation of protein aggregates might contribute to neuroaxonal dystrophy in this disorder. Publication Status: Online-Only"
> "Q68FE2-1","RefSeq","NP_001275541.1","28513333","Atg9a deficiency causes progressive degeneration in the axons and their terminals, but not in neuronal cell bodies."
> "Q68FE2-1","RefSeq","NP_001275541.1","27811852","Study find abnormalities of the bone surface in Atg9a knockout mice, suggesting an important role of Atg9a-dependent necrosis in bone surface formation. Publication Status: Online-Only"
> "Q68FE2-1","RefSeq","NP_001275541.1","20124090","Atg9Ap may be involved in autophagosome formation in the ER and axon terminals of neurons, the TGN, and lysosomes/late endosomes."
> "Q68FE2-1","RefSeq","NP_001275541.1","19926846","STING co-localizes with the autophagy proteins, microtubule-associated protein 1 light chain 3 (LC3) and autophagy-related gene 9a (Atg9a), after dsDNA stimulation."
18013c24259,24262
< "Q5SUQ9-1","RefSeq","NP_001013274.2","22531781","These data demonstrate an essential role for CTC1 in promoting efficient replication and length maintenance of telomeres."
---
> "Q80WG7-1","RefSeq","NP_849203.2","12917430","Results indicated that the novel RBCC protein Haprin plays a key role in the acrosome reaction and fertilization"
> "Q921R8-1","RefSeq","NP_082144.2","27349617","SLC41A3 was established as a new factor for Mg(2+) handling. Publication Status: Online-Only"
> "Q8CH25-1","RefSeq","NP_080613.1","30782847","SLTM regulates GLI factor binding to chromatin and contributes to the transcriptional outcomes of SHH signaling via a novel molecular mechanism."
> "Q8CH25-1","RefSeq","NP_080613.1","17630952","Inhibition of gene expression by STLM appears to result from generalized down-regulation of mRNA synthesis and initiation of apoptosis following SLTM overexpression."
18023a24273,24276
> "P63011-1","RefSeq","NP_033027.1","27423421","Rab3A might function as a marker of cortical granules and participates in cortical granule exocytosis in mouse eggs."
> "P63011-1","RefSeq","NP_033027.1","24965146","Rab3a accelerates cell proliferation by increasing cyclin D1 expression, enhances anti-cancer drug resistance, and increases tumorigenicity and self-renewal of glioma cells."
> "P63011-1","RefSeq","NP_033027.1","24227741","Rab3a deletion restores excitatory/inhibitory imbalance in synapsin II(-) hippocampal slices."
> "P63011-1","RefSeq","NP_033027.1","24205339","Rab3a deficiency promotes constitutive secretion and underlies selective impairment of Ca(2)-dependent release of alpha-MSH Publication Status: Online-Only"
18047a24301,24307
> "Q61164-1","RefSeq","NP_851839.1","30377227","CCCTC-binding factor (CTCF) controls an early fate decision point in the generation of cortical interneurons mediated at least in part by Lhx6"
> "Q61164-1","RefSeq","NP_851839.1","30107916","The results suggest that CTCF plays an essential role in maintaining hair cells and hearing function in mammalian cochlea."
> "Q61164-1","RefSeq","NP_851839.1","30086769","CTCF maintains regulatory homeostasis of cancer pathways. Publication Status: Online-Only"
> "Q61164-1","RefSeq","NP_851839.1","30008200","CTCF plays an essential role in otic neurogenesis by modulating histone modification in the Neurog1 locus."
> "Q61164-1","RefSeq","NP_851839.1","29757144","These findings elucidate the role of intra- megabase-scale Topologically Associating Domains cohesin-and-CTCF binding in nuclear organization associated with widespread insulation of distal enhancer activity. Publication Status: Online-Only"
> "Q61164-1","RefSeq","NP_851839.1","11997516","Conserved CTCF insulator elements flank the mouse and human beta-globin loci."
> "Q61164-1","RefSeq","NP_851839.1","11743158","It's proposed that Tsix and CTCF together establish a regulatable epigenetic switch for X-inactivation."
18053a24314,24317
> "Q9WUF1-1","RefSeq","NP_036041.1","19200072","We show, in vivo, that the genetic replacement of the V1rb2 pheromone receptor coding sequence by an unrelated one from the odorant receptor gene M71 maintains gene exclusion, suggesting that a common mechanism is used to regulate their transcription."
> "Q3TB92-1","RefSeq","NP_001258304.1","30556363","Allergin-1 might play an inhibitory role in autoantibody production via upregulation of macrophage phagocytosis."
> "Q3TB92-1","RefSeq","NP_001258304.1","27932517","The results suggest that Allergin-1 on skin MCs suppresses TLR2-induced dermatitis."
> "Q3TB92-1","RefSeq","NP_001258304.1","24552759","It is a immunoglobulin-like receptor which regulates the activation of mast cell.(review) Review article"
18055a24320,24324
> "Q80Y17-1","RefSeq","NP_032528.1","30597194","Study concludes that lethal giant larvae 1 is essential for radial glial cell development and neural migration during cerebral cortex development."
> "Q80Y17-1","RefSeq","NP_032528.1","29842893","Study showed that Lgl bound with aPKC and PAR-6B competing against PAR-3A in PAR complex which resulted in pleural mesothelial cell (PMCs) polarity loss, and Lgl1 knockdown maintained the PMC polarity and attenuated pleural fibrosis."
> "Q80Y17-1","RefSeq","NP_032528.1","30131568","Data establish Lgl1 as a suppressor of gliomagenesis and positive regulator of asymmetric division and differentiation in the healthy and demyelinated murine brain. Publication Status: Online-Only"
> "Q80Y17-1","RefSeq","NP_032528.1","28552558","Ablation of Llgl1 gene Results in Severe Brain Malformation."
> "Q80Y17-1","RefSeq","NP_032528.1","28472654","Results suggest that neural stem cell-mediated neuron and glia production is tightly regulated through the concerted interplay of sequential Lgl1-dependent global and cell intrinsic mechanisms."
18063,18065c24332,24333
< "O54830-1","RefSeq","NP_001157530.1","12399423","Results show that PRL-like proteins E and F have the same stimulatory effects on megakaryocyte growth and differentiation"
< "O54830-1","RefSeq","NP_001157530.1","12040023","Injection of PLP-E into thrombocytopenic mice restores normal platelet levels with no effect on granulocytes, erythrocytes, and total white blood cell counts"
< "Q80VP5-1","RefSeq","NP_001128189.1","22821833","Determined the solution structure of the GGQ-containing domain (GGQ domain) of C12orf65 from mouse by NMR spectroscopy."
---
> "Q810B9-1","RefSeq","NP_942564.2","29107521","Findings reveal how unique postsynaptic Cell Adhesion Molecules neuroligin 2 and slitrk3 work in concert to control synaptogenesis and establish a general framework for GABAergic synapse development."
> "Q810B9-1","RefSeq","NP_942564.2","22286174","These results identify Slitrk3-PTPdelta as an inhibitory-specific trans-synaptic organizing complex that is required for normal functional GABAergic synapse development. Publication Status: Online-Only"
18067a24336,24337
> "Q9R014-1","RefSeq","NP_036137.1","15680921","These results show that cathepsin P, in contrast to other mammalian cathepsins, has a restricted catalytic specificity."
> "Q9R014-1","RefSeq","NP_036137.1","14629193","Characterization of the catalytic properties of cathepsin P."
18073a24344,24350
> "O88508-1","RefSeq","NP_714965.1","31015495","Study of mice carrying a point mutation (Dnmt3aD329A) in the DNMT3A-PWWP domain, revealed that it is gain of function mutation and results in progressive DNA hypermethylation across domains marked by H3K27me3 and bivalent chromatin and de-repression of developmental regulatory genes in adult hypothalamus that manifests phenotypically as dominant postnatal growth retardation. Publication Status: Online-Only"
> "O88508-1","RefSeq","NP_714965.1","12138111","These findings suggest that Dnmt3a and Dnmt3a2 may have distinct DNA targets and different functions in development."
> "P70351-1","RefSeq","NP_031996.1","30689973","The Polycomb repressive complex 2 proteins EZH1 and EZH2 regulate genes that control hepatocyte maturation and fibrogenesis and genes not specifically associated with the liver lineage by acting at euchromatic promoter regions. EZH1 and EZH2 thereby promote liver homeostasis and prevent liver damage."
> "P70351-1","RefSeq","NP_031996.1","30099093","Depletion of EZH1 in the prefrontal cortex attenuated sociability, enhanced motivational behaviors and affected gene expression pathways."
> "P70351-1","RefSeq","NP_031996.1","29342143","Identification of EZH1 as a repressor of haematopoietic multipotency in the early mammalian embryo"
> "P70351-1","RefSeq","NP_031996.1","28512107","Ezh1 is required for neonatal heart regeneration and development."
> "P70351-1","RefSeq","NP_031996.1","28254491","The expression level of Ezh1 determines the restoration of H3K27 methylation in the absence of the canonical EZH2-PRC2."
18080a24358,24360
> "Q9D2G5-1","RefSeq","NP_035653.2","27878645","Report showing expression, location and isoforms of Synj1 and Synj2 in the small and large intestine and that they might participate in intestinal pathology."
> "Q9D2G5-1","RefSeq","NP_035653.2","24103750","Clustering all known mouse Synj2 transcripts led to uncover a novel subset of transcripts that appears to derive from a region located within intron 7."
> "Q9D2G5-1","RefSeq","NP_035653.2","21423608","These results reveal Synj2 as a critical regulator of hair cell survival that is essential for hair cell maintenance and hearing function. Publication Status: Online-Only"
18085a24366
> "P39054-1","RefSeq","NP_031897.2","30291191","DNM2 knockdown via two different strategies can efficiently correct the myopathy due to DNM2 mutations."
18092a24374,24378
> "P01139-1","RefSeq","NP_038637.1","30934765","NGFbeta directly interacts with adiponectin and SPARC, whereas these interactions oppositely regulate NGFbeta functions. Publication Status: Online-Only"
> "P01139-1","RefSeq","NP_038637.1","30061605","Structural analysis of binding of NGF, proNGF, and proBDNF to SorCS2 Publication Status: Online-Only"
> "P01139-1","RefSeq","NP_038637.1","30430919","Treatment with NGF was found to upregulate both gene and protein expressions as well as total activity of DNA methyltransferases in differentiating HT22 cells."
> "P63250-1","RefSeq","NP_032452.1","29581303","Ethanol activates GIRK1 by shifting the conformational equilibrium processes, which are responsible for the gating of GIRK, to stabilize an open conformation of the cytoplasmic ion gate."
> "P63250-1","RefSeq","NP_032452.1","28464250","Histone H4 hyperacetylation induced by Class I HDACs inhibitors promoted the expression profiles of potassium channels (Kcnj2, Kcnj3, Kcnj5, Kcnj11, and Kcnh2)"
18096,18098c24382,24396
< "O88829-1","RefSeq","NP_001030305.1","30576498","HEK-293T clones permanently expressing HaloTag-ST3GAL5 carrying each of the five variants were assessed by quantitative PCR, flow cytometry, western blotting and confocal microscopy. Compared with the very mild phenotype of st3gal5 KO mouse models, the results suggest that unknown mechanisms, in addition to the lack of a-b-c-series gangliosides, contribute to the syndrome."
< "O88829-1","RefSeq","NP_001030305.1","28808804","A new liver-specific c-type mRNA transcriptional variant of mouse ST3GAL5 protein has been identified."
< "Q8BKT8-1","RefSeq","NP_082909.1","23182369","Data suggest Uchl5ip has role in spindle formation in oocyte meiotic maturation; Uchl5ip protein level is consistent during metaphase I/II; Uchl5ip localizes to meiotic spindle; loss of Uchl5ip disrupts localization of gamma-tubulin to spindle poles."
---
> "Q8K2P7-1","RefSeq","NP_598847.2","29065407","The amino acid transporter gene Slc38a1 appears to be a novel gene responsive to hypoxic stress in a manner dependent on HIF-1alpha in brown adipocytes. In addition to in vitro studies, we showed that the Slc38a1 expression was enhanced in the brown adipose tissue of obesity model mice in vivo."
> "Q8K2P7-1","RefSeq","NP_598847.2","28095293","Hence, pro-degenerative MAPK signaling functions upstream of SARM1 by limiting the levels of the essential axonal survival factor NMNAT2 to promote injury-dependent SARM1 activation. Publication Status: Online-Only"
> "Q8K2P7-1","RefSeq","NP_598847.2","27373508","Changes in transporter expression likely reflect different amino acid requirements during development. Findings include the differential expression of SNAT1 in the inner and outer cells of the compacted morula and nuclear localisation of SNAT2 in the trophectoderm and placental lineages."
> "Q8K2P7-1","RefSeq","NP_598847.2","25957749","Overexpression of X-box binding protein-1 led to a marked increase in luciferase activity in P19 cells transfected with the Slc38a1 reporter plasmid. These results suggest that theanine accelerates cellular proliferation and subsequent neuronal specification through a mechanism relevant to upregulation of Slc38a1 gene in undifferentiated neural progenitor cells"
> "Q8K2P7-1","RefSeq","NP_598847.2","25673846","We found that MeCP2 acts as a microglia-specific transcriptional repressor of"
> "Q6P1B3-1","RefSeq","NP_783627.2","27349870","Thus, Leda-1/Pianp is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10/17 and intramembrane protease gamma-secretase."
> "Q6P1B3-1","RefSeq","NP_783627.2","26188512","Demonstrate that counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilralpha is part of the complex innate immune response of macrophages and its genetically determined strain-specific modulation"
> "Q6P1B3-1","RefSeq","NP_783627.2","23558288","Furin-like proprotein convertase-dependent processing precedes the plasma membrane localization of LEDA-1/PIANP that is required for functional receptor-ligand interactions in vitro and in vivo."
> "Q6P1B3-1","RefSeq","NP_783627.2","21241660","These results suggest that PANP is involved in immune regulation as a ligand of the PILRalpha."
> "A7KBS4-1","RefSeq","NP_001093656.1","26997646","Data show that zinc finger protein 42 (Rex1) and zinc finger and SCAN domain containing 4D/4C (Zscan4D/4C) correlate with the cell-cycle length under different mechanisms."
> "A7KBS4-1","RefSeq","NP_001093656.1","23739662","These results indicate the active roles of Zscan4 in the long-term maintenance of embryonic stem cell potency.[Zscan4]"
> "A7KBS4-1","RefSeq","NP_001093656.1","18580041","Inhibiting the first round increased the expression levels of hsp70.1, eif-1a and zscan4d but decreased that of muerv, while inhibiting the second round increased the expression levels of all four genes."
> "Q60929-1","RefSeq","NP_001278125.1","29054930","Canonical pathway analysis of genes preferentially dysregulated in the atria and ventricles revealed distinct MEF2A-dependent cellular processes in each cardiac chamber. In the atria, MEF2A regulated genes involved in fibrosis and adhesion, whereas in the ventricles, it controlled inflammation and endocytosis."
> "Q60929-1","RefSeq","NP_001278125.1","28965945","Deficiency of AKT2 in myocardium results in diminished MEF2A abundance, which induced decreased size of cardiomyocytes. We additionally confirmed that EndoG, which is also regulated by AKT2, is a suppressor of MEF2A in myocardium."
> "Q60929-1","RefSeq","NP_001278125.1","28901289","Both synapse silencing and elimination required de novo transcription, but only silencing required the activity-dependent transcription factors MEF2A/D. Publication Status: Online-Only"
18105a24404,24408
> "Q9ES74-1","RefSeq","NP_067618.1","29899413","NEK7 regulates dendrite morphogenesis in vitro and in vivo. NEK7 kinase activity is required for dendrite growth and branching, as well as spine formation and morphology. NEK7 regulates these processes in part through phosphorylation of the kinesin Eg5/KIF11, promoting its accumulation on microtubules in distal dendrites. Publication Status: Online-Only"
> "Q9ES74-1","RefSeq","NP_067618.1","26642356","NEK7 serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division."
> "Q9ES74-1","RefSeq","NP_067618.1","26814970","NEK7 is an essential protein that acts downstream of potassium efflux to mediate NLRP3 inflammasome assembly and activation"
> "Q9ES74-1","RefSeq","NP_067618.1","26553871","Murine macrophages deficient in Nek7 displayed a largely blunted Nlrp3 inflammasome response."
> "Q9ES74-1","RefSeq","NP_067618.1","11744387","During early embryogenesis nek7 is expressed in the site of decidual reaction. Later in embryogenesis, nek7 is highly expressed in the dorsal thalamus."
18112a24416,24417
> "Q91WE9-1","RefSeq","NP_598857.1","29453251","Novel adipokine, FAM19A5, was capable of inhibiting postinjury neointima formation via sphingosine-1-phosphate receptor 2-G12/13-RhoA signaling."
> "Q91WE9-1","RefSeq","NP_598857.1","29138422","Our results suggest that FAM19A5 and its target receptor FPR2 can act as novel endogenous ligand/receptor to negatively regulate osteoclastogenesis. They might be regarded as potential targets to control osteoclast formation and bone disorders. Publication Status: Online-Only"
18119a24425,24427
> "P05366-1","RefSeq","NP_033143.1","30892738","This study confirmed that SAA1 was a prominent protein that increased IL-17 levels through TLR2 in gammadelta T cells, confirming the possibility that SAA1 may exacerbate inflammatory diseases through gammadelta T cells."
> "P05366-1","RefSeq","NP_033143.1","29366677","The present work demonstrates an important role for SAA in epithelial wound recovery and provides evidence for a physiological role in the wound environment."
> "P05366-1","RefSeq","NP_033143.1","29351990","High SAA1 expression in the stromal component is associated with pancreatic tumors."
18121a24430,24433
> "Q9QZB0-1","RefSeq","NP_064342.1","21348811","This RGSZ2-dependent regulation of NMDAR activity is relevant to persistent pain disorders associated with heightened NMDAR-mediated glutamate responses and the reduced antinociceptive capacity of opioids."
> "Q9QZB0-1","RefSeq","NP_064342.1","22163035","SUMO-SIM interactions regulate the activity of RGSZ2 proteins"
> "Q9QZB0-1","RefSeq","NP_064342.1","18652891","These results indicate that the NMDAR/nNOS cascade, activated via MORs, provide the free zinc ions required for inactive PKCgamma to bind to HINT1/RGSZ complex at the C terminus of the receptor."
> "Q8BUE7-1","RefSeq","NP_666183.2","15314156","Results suggest that MUC20 is a novel regulator of the Met signaling cascade which has a role in suppression of the Grb2-Ras pathway."
18148a24461,24463
> "P16858-1","RefSeq","NP_032110.1","20972425","Gapdh is a moonlighting protein that functions as a glycolytic enzyme and a nuclear protein nitrosylase."
> "P16858-1","RefSeq","NP_032110.1","18809573","Gapdh is a moonlighting protein that functions as a glycolytic enzyme and additionally is involved in regulating mRNA stability."
> "P16858-1","RefSeq","NP_032110.1","17121833","GAPDH interacts with transferrin and the GAPDH-transferrin complex is subsequently internalized into the early endosomes. GeneRIF: Gapdh is a moonlighting protein that functions as a glycolytic enzyme and a transferrin receptor."
18169a24485
> "O70576-1","RefSeq","NP_058660.2","27172213","Our genetic analysis demonstrates that cohesins containing STAG3 and REC8 are the main complex required for centromeric cohesion, and RAD21L cohesins are required for normal clustering of pericentromeric heterochromatin. Furthermore, the STAG3/REC8 and STAG3/RAD21L cohesins are the primary cohesins required for axis formation. Publication Status: Online-Only"
18180a24497,24502
> "Q9JIQ8-1","RefSeq","NP_056590.2","28759649","DPP4:CD9:TTSP as the protein complexes are necessary for early efficient MERS-coronavirus entry. Publication Status: Online-Only"
> "P0CW02-1","RefSeq","NP_034871.2","30291130","The Ym1(+)Ly6C(hi) monocytes greatly expanded in bone marrow during the recovery phase of systemic inflammation or tissue injury."
> "P0CW02-1","RefSeq","NP_034871.2","29358280","TCR-dependent and cytokine-mediated signals that modulate T cell expression of Ly6C and Sca-1 in vitro and in vivo during infection."
> "P0CW02-1","RefSeq","NP_034871.2","28663258","Surface expression on Ly6C(high) monocytes changes in a time-of-day-dependent manner, which crucially affects cardiac monocyte recruitment after an acute ischemic event."
> "P0CW02-1","RefSeq","NP_034871.2","28691930","CX3CL1 is upregulated in both human and murine tumors following VEGF signaling blockade, resulting in recruitment of CX3CR1+Ly6Clo monocytes into the tumor"
> "P0CW02-1","RefSeq","NP_034871.2","28534119","Splenic Ly6C(hi) monocytes contribute to adverse late post-ischemic left ventricular remodeling in heme oxygenase-1 deficient mice."
18190a24513,24517
> "P41216-1","RefSeq","NP_032007.2","23426369","Acyl-CoA synthetase 1 is induced by Gram-negative bacteria and lipopolysaccharide and is required for phospholipid turnover in stimulated macrophages"
> "P41216-1","RefSeq","NP_032007.2","21245374","Acsl1 is required for heart fatty acid oxidation. Heart-specific Acsl1 deficiency causes cardiac hypertrophy."
> "P41216-1","RefSeq","NP_032007.2","19648649","Results describe a knock-out model of acyl-CoA synthetase-1 (ACSL1) and its effects in liver and in whole body metabolism."
> "Q8BLU2-1","RefSeq","NP_001013821.1","29719249","METTL21C trimethylates p97 on the Lys315 residue and found that loss of this modification reduced p97 hexamer formation and ATPase activity in vivo."
> "Q8BLU2-1","RefSeq","NP_001013821.1","24677265","Mettl21c knockdown modulated only the NF-kappaB signaling pathway."
18195a24523,24525
> "O54714-1","RefSeq","NP_666247.1","29896300","PIAS3-mediated feedback loops control cell proliferation and function as robust driving forces for Colitis-associated colorectal cancer (CAC) progression. Publication Status: Online-Only"
> "O54714-1","RefSeq","NP_666247.1","27845432","Results show that PIAS3 levels are reduced in a mouse model of atherosclerotic lesions and that its expression decreases in conjunction with increases in interleukin-6 expression and disease severity. These findings provide evidence that results indicate that PIAS3 is a critical repressor of atherosclerosis progression. Publication Status: Online-Only"
> "O54714-1","RefSeq","NP_666247.1","25713074","Data indicate that PIAS3 (protein inhibitor of activated STAT3) interaction modulates EKLF (erythroid Kruppel-like factor) activity in a promoter-dependent and SUMO-independent manner."
18218d24547
< "Q7TQ62-1","RefSeq","NP_001272885.1","15063725","Podn was characterized in cultured mouse cells."
18222a24552,24553
> "O35892-1","RefSeq","NP_001300642.1","31180531","Findings demonstrated that spheroids from pancreatic cancer cells caused circular defects in lymphatic endothelial monolayers. These CCIDs in pancreatic cancer were partly regulated by S100P."
> "O35892-1","RefSeq","NP_001300642.1","11471051","Identification and analysis of the genes Sp100, Csprs, and Ifi75 in two members of the genus Mus, M. musculus and M. caroli"
18230,18231d24560
< "Q3URD3-1","RefSeq","NP_001297374.1","22180652","These data demonstrate that SLMAP is a regulator of E-C coupling at the level of the SR and its perturbation results in progressive deterioration of cardiac electrophysiology and function."
< "Q3URD3-1","RefSeq","NP_001297374.1","21785580","SLMAP may be an important regulator of glucose uptake or involved in GLUT-4 fusion/translocation into the plasma membrane of mouse abdominal adipose tissue; changes in SLMAP expression are linked to hyperglycemia and diabetes."
18237,18238c24566,24567
< "A2AMT1-1","RefSeq","NP_001277990.1","29196765","AQP0 modulates GJs in the presence of BF proteins to maintain lens transparency and homeostasis."
< "A2AMT1-1","RefSeq","NP_001277990.1","27559293","CP49 and filensin have been considered robust markers for mouse lens fiber cell differentiation. The data reported here, however, document both proteins in the mouse lens epithelium, but only after 5 weeks of age, when lens epithelial growth and mitotic activity have slowed. Publication Status: Online-Only"
---
> "O35698-1","RefSeq","NP_035383.2","20016065","Regulates germline-specific splicing events"
> "O35698-1","RefSeq","NP_035383.2","18492746","MRBMY protein may have high affinity to oligo(A) rich sequences; mRBMY protein can bind to the testis and sperm-specific spa17 mRNA"
18239a24569
> "P70210-1","RefSeq","NP_035696.3","10379887","Experimental evidence for non-AUG translation initiation of human TEF-5. This non-AUG start site, AUA, is conserved in mouse."
18240a24571,24572
> "Q9D385-1","RefSeq","NP_077231.1","29718757","ARL2BP is necessary for photoreceptor ciliary doublet formation and axoneme elongation."
> "Q9D385-1","RefSeq","NP_077231.1","18234692","BART is essential for the transcriptional activity and nuclear retention of STAT3"
18251a24584,24594
> "Q9WV38-1","RefSeq","NP_062715.2","29259131","Identified amino acid residues of GLUT5 that define its substrate specificity for glucose transporter 5 (GLUT5)-mediated fructose transport."
> "Q9WV38-1","RefSeq","NP_062715.2","19082670","MRNA expression of GLUT5 varied diurnally in the duodenum, jejunum and ileum mucosa.  GLUT5 protein level varied diurnally in duodenum and jejunum, but not in the ileum."
> "Q9WV38-1","RefSeq","NP_062715.2","18496516","The essential role of chloride and fructose absorbing Slc2a5 is reported."
> "Q9WV38-1","RefSeq","NP_062715.2","18417103","We conclude that Glut5 is not required for OHC motility or cochlear amplification."
> "Q8BJL1-1","RefSeq","NP_082244.2","30980108","SLBP overexpression caused by Fbxo30 depletion results in a remarkable overload of histone H3 on chromosomes that excessively condenses chromosomes and inhibits chromosome segregation. The finding uncovers an unidentified pathway-controlling chromosome segregation and cell progress."
> "Q8BJL1-1","RefSeq","NP_082244.2","27117404","Fbxo30-Eg5 interaction as a critical checkpoint in mammopoiesis."
> "Q8BJL1-1","RefSeq","NP_082244.2","24076600","MUSA1 inhibition significantly protected denervated muscles from atrophy and the drastic atrophy seen in Smad4-deficient muscles was blunted [MUSA1]"
> "Q99MV5-1","RefSeq","NP_112550.2","27655786","Mutations in the conserved ATP hydrolysis motif of MOV10L1 block piRNA biogenesis and result in male sterility."
> "Q99MV5-1","RefSeq","NP_112550.2","25762440","MOV10L1 RNA helicase activity promotes unwinding and funneling of the single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing GeneRIF: MOV10L1 exhibits 5'-to-3' directional RNA-unwinding activity in vitro and its RNA helicase activity is required for primary piRNA biogenesis in vivo. MOV10L1 selectively binds piRNA precursor transcripts. MOV10L1 is essential for the generation of intermediate piRNA processing fragments. piRNA precursor processing is intimately coupled with elements of local secondary structures such as G quadruplexes."
> "Q99MV5-1","RefSeq","NP_112550.2","12754203","Nkx2.5 transactivates the Csm promoter, suggesting that Nkx2.5 is essential for embryonic Csm (cardiac-specific isoform of Mov10l1) expression"
> "Q99MV5-1","RefSeq","NP_112550.2","11854500","CHAMP acts as an inhibitor of cell proliferation and cardiomyocyte hypertrophy."
18252a24596,24598
> "Q08288-1","RefSeq","NP_079557.2","25735755","These results suggest that Lyar is a genuine RPE phagocytosis ligand, which in turn supports the validity of OPD/PFC as the only available approach for unbiased identification of phagocytosis ligands with broad applicability to various phagocytes"
> "Q08288-1","RefSeq","NP_079557.2","24990247","Results show that LYAR protein expression is testis-predominant but can also be found in cancer cells originated from tissues other than testis. Lyar seems to promote proliferation of NIH-3T3 cells."
> "Q08288-1","RefSeq","NP_079557.2","22815056","Lyar is a novel candidate gene for a role in human neural tube defects."
18295,18296d24640
< "A2ASZ8-1","RefSeq","NP_001277487.1","28588221","These findings suggest that KD feeding induces expression of the muscle circadian gene Slc25a25 via neural pathways, and that SLC25A25 might be involved in muscle thermogenesis under KD-induced hypothermia in mammals. Publication Status: Online-Only"
< "A2ASZ8-1","RefSeq","NP_001277487.1","21296886","Induction of Slc25a25 in mice with an intact gene may contribute to an alternative thermogenic pathway for the maintenance of body temperature during cold stress."
18306a24651,24655
> "O70477-1","RefSeq","NP_057879.2","30337366","A mechanism by which the DNA binding-independent activity of Sp2 potentiates genomic loading of Pbx1:Prep1 and Nf-y to composite motifs present in many promoters of highly expressed genes"
> "O70477-1","RefSeq","NP_057879.2","29349576","Prep1 deficiency alters olfactory morpho-functional integrity and olfaction-mediated eating behavior by affecting BDNF-TrkB signaling."
> "O70477-1","RefSeq","NP_057879.2","29474930","Prep1 silencing reduces inflammatory response and increases insulin sensitivity in adipose tissue."
> "O70477-1","RefSeq","NP_057879.2","29293683","Results indicate that PKnox1 is a critical regulator of maintenance and subsequent differentiation of the c-Kit+ stage of spermatogonia in the adult testes Publication Status: Online-Only"
> "O70477-1","RefSeq","NP_057879.2","30604852","We conclude that Prep1 is required for normal adult mammary gland development, in particular at its branching morphogenesis step. By binding Snail2, Prep1 protects it from the proteasomal degradation."
18312a24662,24663
> "P35639-1","RefSeq","NP_031863.3","30894532","Endoplasmic reticulum stress stress-induced mediator CHOP thwarts effector T cell activity in tumors through T-bet repression. Erratum:[Nat Commun. 2019 Aug 15;10(1):3680. PMID: 31417079] Publication Status: Online-Only"
> "P35639-1","RefSeq","NP_031863.3","30567393","Tunicamycin (TM) treatment significantly increased mRNA levels of CHOP and GRP78, and induced lipid accumulation in the liver. Lipid peroxidation in the liver tissue also increased from TM treatment (CON vs. TM; 3.0 +/- 1.8 vs. 11.1 +/- 0.8 nmol MDA/g liver, p < 0.001), which reflects an imbalance between the generation of reactive substances and antioxidant capacity Publication Status: Online-Only"
18321a24673,24675
> "O54946-1","RefSeq","NP_035977.2","21972064","Mrj(-/-) chorions at embryonic day 8.5 have expanded Rhox4b expression domains and do not form normal layers of gene expression suggesting that chorion patterning requires Mrj."
> "O54946-1","RefSeq","NP_035977.2","19777589","Data show that Mrj(-/-) embryos exhibit neural tube defects independent of the placenta phenotype, including exencephaly and thin-walled neural tubes, and suggest that Mrj plays an important role in neural stem cell self-renewal."
> "O54946-1","RefSeq","NP_035977.2","18373498","DnaJB6 is necessary for translocation of Slfn1 into the nucleus, where Slfn1 down-regulates cyclin D1, induces cell-cycle arrest and programmes a quiescent state of T-cells"
18327a24682,24684
> "P50462-1","RefSeq","NP_038836.1","30279005","Ablation of MLP protein (and MYBPC3) protected mice from developing the dilated cardiomyopathy phenotype."
> "P50462-1","RefSeq","NP_038836.1","29634311","We identify a novel role for Csrp3 expression in skeletal muscle in the development of obesity-induced insulin resistance"
> "P50462-1","RefSeq","NP_038836.1","30048712","Our cellular experiments suggest that protein depletion and proteasomal overload also play a role in other HCM-causing CSPR3 mutations that we investigated, indicating that reduced levels of functional MLP may be a common mechanism for HCM-causing CSPR3 mutations."
18332a24690,24691
> "Q8BGB7-1","RefSeq","NP_080697.2","24236849","Our result suggests a significant role for enoph1 and polyamines in anxiety and depression-related behaviors."
> "Q8BGB7-1","RefSeq","NP_080697.2","19139748","Both single-nucleotide polymorphisms were significantly associated with locomotion-independent trait anxiety, further supporting a functional role of EP for this phenotype."
18363a24723,24726
> "Q8K1I7-1","RefSeq","NP_694778.1","26453379","WIPf1 deficiency results in defective B cell function. By regulating the cortical actin cytoskeleton, WIPf1 influences the function of CD19 as a general hub for PI3K signaling."
> "Q8K1I7-1","RefSeq","NP_694778.1","26664784","These experiments identify WIP as a member of a signaling cascade comprised of Abl family kinases, mTORC1 and S6K, which regulates neuron development and specifically, neuritic branching and complexity. Publication Status: Online-Only"
> "Q8K1I7-1","RefSeq","NP_694778.1","25246631","WIP binding to actin, independently of its binding to Wiskott-Aldrich syndrome protein, is critical for the integrity of the actin cytoskeleton in T cells and for their migration into tissues."
> "Q8K1I7-1","RefSeq","NP_694778.1","12724353","WIP participates in the actin reorganization that leads to ruffle formation."
18366d24728
< "Q5RKZ7-1","RefSeq","NP_064426.2","15862276","Inactivity results in elevated sulfite and diminished sulfate levels throughout the organism, and various brain dysmorphisms."
18372a24735
> "Q9CWY9-1","RefSeq","NP_081462.1","19192389","The alternative splicing of RIPalpha in the Drosophila, Xenopus, and mouse system, was examined."
18376a24740,24741
> "P50652-1","RefSeq","NP_001334443.1","29989666","FancA(-/-) and FancC(-/-) embryos have abnormal skeletal development shown by skeletal malformations, growth delay, and reduced bone mineralization."
> "P50652-1","RefSeq","NP_001334443.1","29427417","TP53 haploinsufficiency completely rescues emergency granulopoiesis in FANCC(-/-) mice."
18378a24744,24747
> "Q69ZR9-1","RefSeq","NP_083221.1","28839193","This data demonstrates a new in vivo function of Fam208a in maintaining epiblast fitness, establishing it as an important factor at the onset of gastrulation when cells are exiting pluripotency. Erratum:[Sci Rep. 2018 Apr 5;8(1):5762. PMID: 29622773] Publication Status: Online-Only"
> "Q69ZR9-1","RefSeq","NP_083221.1","24781204","D14Abb1e is localised to the nucleus and is expressed in skin and testes."
> "Q9D1X0-1","RefSeq","NP_084428.1","30415165","Our data revealed the pivotal role of ARC in myocardial necrosis and delineated the p53-ARC-CypD/mPTP central necrosis pathway, which can provide a potential therapeutic avenue for ischemia and oxidative stress-related cardiac diseases."
> "Q9D1X0-1","RefSeq","NP_084428.1","27556499","Data suggest that reduced levels of apoptosis repressor with caspase recruitment domain protein (ARC) might correlate with neomycin-induced hair cells (HCs) loss."
18399a24769
> "Q6ZPF3-1","RefSeq","NP_036008.2","30817801","Tiam2 is expressed in two isoforms, the full-length (Tiam2l) and a short transcript (Tiam2s). Tiam2s expression from the t-allele is strongly increased compared to the wild-type allele. By transgenic approaches we show that Tiam2s enhances t-haplotype transmission, while Tiam2l has the opposite effect. Publication Status: Online-Only"
18405a24776
> "Q80UW0-1","RefSeq","NP_056634.3","15499561","6OST2 is more mesenchymal than its isoenzymes during development"
18423a24795,24797
> "Q793I8-1","RefSeq","NP_660115.1","23722163","The increase in TIFA level appears to be a feed-forward mechanism involved in TLR4/MyD88-dependent signaling, leading to NF-kappaB activation and HMGB1 release"
> "Q793I8-1","RefSeq","NP_660115.1","16643855","We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA after LPS treatment and suppresses the TRAF6-dependent activation of NF-kappaB. Erratum:[Biochem Biophys Res Commun. 2007 Feb 23;353(4):1121]"
> "Q793I8-1","RefSeq","NP_660115.1","12566447","TIFA is likely to mediate IRAK-1/TRAF6 interaction upon IL-1 stimulation"
18464a24839
> "P98197-1","RefSeq","NP_056619.1","30355768","ATP11A and ATP11C in precursor B cells are essential for rapidly internalizing PtdSer from the cell surface to prevent the cells' engulfment by macrophages."
18473a24849,24853
> "Q9WV31-1","RefSeq","NP_061260.1","31110186","Study demonstrates that the immediate early gene, Activity Regulated Cytoskeleton Associated Protein (Arc), is selectively and persistently expressed in mouse dentate gyrus of the hippocampus engram cells after fear conditioning. Publication Status: Online-Only"
> "Q9WV31-1","RefSeq","NP_061260.1","30442670","These results demonstrate that Arc/Arg3.1 mediates a critical period for spatial learning, during which Arc/Arg3.1 fosters maturation of hippocampal network activity necessary for future learning and memory storage."
> "Q9WV31-1","RefSeq","NP_061260.1","22036569","Study reports that the immediate early gene Arc is required for activity-dependent generation of Abeta. Arc is a postsynaptic protein that recruits endophilin2/3 and dynamin to early/recycling endosomes that traffic"
> "Q9WV31-1","RefSeq","NP_061260.1","12493697","Highly expressed both at the RNA and protein levels in postmeiotic germ cells in the testis of adult mice"
> "Q9WV31-1","RefSeq","NP_061260.1","12617955","Arc, an activity-regulated cytoskeletal gene, is expressed in suprachiasmatic nucleus neurons and is possibly involved in the light-induced phase-shift of circadian rhythm."
18481a24862,24867
> "Q69ZN7-1","RefSeq","NP_001289069.1","30333125","Data demonstrate myoferlin's critical role in lysosomal exocytosis by phagocytes"
> "Q69ZN7-1","RefSeq","NP_001289069.1","20571050","Increased expression in myofibres after muscle injury and in a mouse model of muscular dystrophy"
> "Q69ZN7-1","RefSeq","NP_001289069.1","20008164","IGF1 receptor recycling is required for normal myogenesis and myoferlin is a critical mediator of postnatal muscle growth mediated by IGF1"
> "Q69ZN7-1","RefSeq","NP_001289069.1","17702744","Myoferlin forms a complex with dynamin-2 and VEGFR-2, which prevents CBL-dependent VEGFR-2 polyubiquitination and proteasomal degradation."
> "Q69ZN7-1","RefSeq","NP_001289069.1","16280346","Myoferlin plays role in the maturation of myotubes and the formation of large myotubes that arise from the fusion of myoblasts to multinucleate myotubes."
> "Q69ZN7-1","RefSeq","NP_001289069.1","11959863","Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains. (myoferlin)"
18489a24876,24882
> "Q9Z0F4-1","RefSeq","NP_036000.1","29653104","Mouse erythrocyte calmyrin is an interacting molecule of the rodent malaria parasite Plasmodium yoelii RhopH complex."
> "Q9Z0F4-1","RefSeq","NP_036000.1","28939911","Study shows that Cib1 negatively regulates degeneration of dopaminergic neurons in a mouse model of Parkinson's disease using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Cib1 physically associated with apoptosis signal-regulating kinase 1 (Ask1) and thereby inhibited the 1-methyl-4-phenylpyrinidium-induced stimulation of the Ask1-mediated signaling cascade. Publication Status: Online-Only"
> "Q9Z0F4-1","RefSeq","NP_036000.1","28542214","Results suggest that interaction of CIB1 with alphaIIb is one of the early events occurring during outside-in signaling. Furthermore, CIB1 recruits FAK to the alphaIIbbeta3 complex at the filopodia where FAK is activated, which in turn activates c-Src, resulting in propagation of outside-in signaling leading to platelet spreading. Publication Status: Online-Only"
> "Q32MG2-1","RefSeq","NP_080733.2","12204287","Immunogold electron microscopy revealed that the protein is restricted, from its first detectable appearance, to a unique spermatid organelle called the 'flower-like structure'"
> "Q8VCD7-1","RefSeq","NP_659036.1","29438700","LSD1 and JMJD2C disable oncogenic Ras- or Braf-induced senescence by enabling the expression of E2F target genes Erratum:[Cancer Cell. 2018 Apr 9;33(4):785. PMID: 29634951]"
> "Q8VCD7-1","RefSeq","NP_659036.1","30537731","CircZMYM2 repressed the expression of its target miR-335-5p. MiR-335-5p attenuated pancreatic cancer development via inhibition of JMJD2C."
> "Q8VCD7-1","RefSeq","NP_659036.1","17938240","Jmjd2c acts as a positive regulator for Nanog, which encodes for a key transcription factor for self-renewal in ES cells."
18492,18494d24884
< "P08923-1","RefSeq","NP_976220.2","22079349","In hippocampus, Ltk and Alk (anaplastic lymphoma kinase) are expressed throughout dentate gyrus, CA1, and CA3. Data suggest genetic interactions between Ltk and Alk in neurogenesis and behavioral measures (i.e., activity, anxiety, spatial memory)."
< "P08923-1","RefSeq","NP_976220.2","18854310","LAR regulates Fyn/JAK2/STAT3 and Fyn/p38 MAPK pathways involved in ROS-induced apoptosis"
< "P08923-1","RefSeq","NP_976220.2","2357970","Translation initiates from a non-AUG codon (CUG) in some Ltk transcript variants."
18497a24888
> "P08226-1","RefSeq","NP_033826.2","30949516","Analysis of the APOE( *)3-Leiden.glucokinase(+/-) (E3L.GK(+/-)) mouse reveals that it is a model of metabolic syndrome and diabetic complications Publication Status: Online-Only"
18509a24901
> "O54791-1","RefSeq","NP_034885.1","22158967","MafF, MafG, and MafK triple-knockout mice developed normally until embryonic day 9.5 (E9.5). Thereafter, however, the triple-knockout embryos showed severe growth retardation and liver hypoplasia, and the embryos died around E13.5."
18516a24909,24911
> "P51954-1","RefSeq","NP_780298.2","28982183","Reduction in ADD1 protein in NEK1 mutant mice is associated with hyperphosphorylation of ADD1, thereby preventing the interaction with MYO10 during meiotic spindle formation Publication Status: Online-Only"
> "P51954-1","RefSeq","NP_780298.2","27760328","NEK1 phosphorylates PP1gamma, leading to the dephosphorylation of WAPL, which, in turn, results in its retention on chromosome cores to promote loss of cohesion at the end of prophase I in mammals."
> "P51954-1","RefSeq","NP_780298.2","25030234","Nek1 is detectable in all murine tissues but its expression in wild type and kat2J heterozygous kidneys decrease as the kidneys mature. In the embryonic kidney, Nek1 expression is most prominent in cells that will become podocytes and proximal tubules. Publication Status: Online-Only"
18525,18527d24919
< "O88576-1","RefSeq","NP_001035782.1","26240152","Analysis of the interaction of amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin"
< "O88576-1","RefSeq","NP_001035782.1","19478081","In contrast to its association with ACE2 observed in Xenopus oocytes, experiments with ace2 and collectrin null mice demonstrate that in vivo it is Collectrin, a smaller homologue of ACE2, that is required for functional expression of XT2 in kidney."
< "O88576-1","RefSeq","NP_001035782.1","15121838","The XT2 orphan transporter is involved in glycine reabsorption, and the absence of this transporter is sufficient to cause hypertension."
18550a24943,24945
> "Q6ZQM0-1","RefSeq","NP_080373.1","24114843","EGF, which signals through CRAF, and an activated BRAF mutant also activate PKC and stimulate cell migration through up-regulating RFFL expression."
> "Q6ZQM0-1","RefSeq","NP_080373.1","19138581","CARP2 [Rififylin] deficiency does not alter induction of NF-kappaB by TNFalpha."
> "Q6ZQM0-1","RefSeq","NP_080373.1","15229288","Data show that the the amino-terminal domain of rififylin is critical for its recruitment to recycling endocytic membranes and for the inhibition of recycling."
18555a24951,24955
> "Q91V24-1","RefSeq","NP_038878.1","28091533","Study demonstrates that changes in surface CD1d expression and intracellular trafficking, as well as reduced CD1d localization to lipid rafts, are all caused by the absence of the ATP binding cassette transporter ABCA7. Publication Status: Online-Only"
> "Q91V24-1","RefSeq","NP_038878.1","27030769","This study demonstrated that novel mechanism underlying how dysfunctions of ABCA7 contribute to the risk for alzheimer disease."
> "Q91V24-1","RefSeq","NP_038878.1","26792809","ABCA7 does not play a significant role in the regulation of cell proliferation or neurogenesis in the adult mouse. Publication Status: Online-Only"
> "Q91V24-1","RefSeq","NP_038878.1","26260791","ABCA7 has a role in Alzheimer amyloid processing"
> "Q91V24-1","RefSeq","NP_038878.1","12917409","ABCA7 has the ability to bind apolipoproteins and promote efflux of cellular phospholipids without cholesterol, and has a possible role of ABCA7 in cellular phospholipid metabolism in peripheral tissues"
18561a24962,24964
> "Q6KCD5-1","RefSeq","NP_957684.1","28041881","Depletion of Zfp609 or Nipbl from cortical neural progenitors in vivo is detrimental to neuronal migration. Zfp609 and Nipbl overlap at genomic binding sites independently of cohesin and regulate genes that control cortical neuron migration."
> "Q6KCD5-1","RefSeq","NP_957684.1","27606604","Nipbl transgenic mice display large atrial septal defects. Publication Status: Online-Only"
> "Q6KCD5-1","RefSeq","NP_957684.1","19763162","Mice heterozygous for a gene-trap mutation in Nipbl were produced and exhibited defects characteristic of Cornelia de Lange Syndrome."
18566,18573c24969
< "Q8C2S5-1","RefSeq","NP_001153435.1","29470856","Increased intracellular growth due to compromised expressions of Fpn and FBXL5 by specific siRNAs reveals that Leishmania donovani uses a novel strategy of manipulating IRP2-FBXL5 axis to inhibit host Fpn expression."
< "Q8C2S5-1","RefSeq","NP_001153435.1","28714470","Conditional deletion of Fbxl5 in mouse HSCs results in cellular iron overload and a reduced cell number. Bone marrow transplantation reveals that FBXL5-deficient HSCs are unable to reconstitute the hematopoietic system of irradiated recipients as a result of stem cell exhaustion. Transcriptomic analysis shows abnormal activation of oxidative stress responses and the cell cycle in FBXL5-deficient mouse HSCs. Publication Status: Online-Only"
< "Q8C2S5-1","RefSeq","NP_001153435.1","28069738","FBXL5 contributes to regulation of neural stem progenitor cell proliferation during mammalian brain development. Publication Status: Online-Only"
< "Q8C2S5-1","RefSeq","NP_001153435.1","24508277","We describe the iron and oxygen sensing mechanisms of the FBXL5 Hr-like domain and its role in mediating ROS biology. Review article"
< "Q91V57-1","RefSeq","NP_001106717.2","28346224","These findings reveal a role for ephrin bidirectional signaling upstream of mutant alpha2-chimaerin in Duane retraction syndrome, which may contribute to the selective vulnerability of abducens motor neurons in this disorder"
< "Q91V57-1","RefSeq","NP_001106717.2","17719550","Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of Efnb3 forward signaling"
< "Q91V57-1","RefSeq","NP_001106717.2","16446429","Lpha1-chimaerin is an activity-regulated Rho GTPase regulator that is activated by phospholipase Cbeta-coupled cell surface receptors and contributes to pruning of dendritic arbors"
< "Q91V57-1","RefSeq","NP_001106717.2","15447672","Chimaerin, one of the Rho GTPase activating proteins, is transcriptionally up-regulated after exposure to neurotrophins in post-natal cerebellar neurons."
---
> "Q9JJG0-1","RefSeq","NP_996738.2","15226440","Results suggest that TACC2 is not required for mouse development and normal cell proliferation and is not a tumor suppressor protein."
18579,18584c24975,24979
< "Q60604-1","RefSeq","NP_001139668.1","29724913","IL1beta and TNFalpha enhance RANKL-dependent expression of adseverin, which contributes to fusion processes in osteoclastogenesis Publication Status: Online-Only"
< "Q60604-1","RefSeq","NP_001139668.1","28389691","Indicate that in healthy, developing tissues, adseverin contributes to the regulation of osteoclast structure but not to bone metabolism in vivo"
< "Q60604-1","RefSeq","NP_001139668.1","26642432","Adseverin knockdown also suppressed the RANKL-mediated induction of nuclear factor of activated T-cell c1 (NFATc1), which is a key transcription factor in osteoclastogenesis. Publication Status: Online-Only"
< "Q60604-1","RefSeq","NP_001139668.1","25681458","Data indicate that adseverin (Ads) regulates actin cytoskeleton in osteoclasts."
< "Q60604-1","RefSeq","NP_001139668.1","25275604","Ads is a RANKL induced early regulator of osteoclastogenesis with a potential role in pre-osteoclast differentiation and fusion. Publication Status: Online-Only"
< "Q60604-1","RefSeq","NP_001139668.1","11883943","Adseverin induction is a specific gene regulatory effect by TCDD on thymocytes."
---
> "Q9ERD6-1","RefSeq","NP_076373.3","17462626","RalGPS2 was characterized."
> "Q8R3G9-1","RefSeq","NP_666122.1","28777493","Single nucleotide polymorphism in TSPAN8 gene is associated with pathogenesis of bipolar disorder."
> "Q8R3G9-1","RefSeq","NP_666122.1","27733379","Transplantation studies provided definitive evidence that a TSPAN8-high subpopulation is enriched for spermatogonial stem cells."
> "Q8R3G9-1","RefSeq","NP_666122.1","20733586","Results argue for a role for Tspan8 in body-weight regulation in males, but do not show differences in T2D-associated traits that were anticipated from previous human genome-wide association studies."
> "Q8R3G9-1","RefSeq","NP_666122.1","20531244","Results suggest that alterations in gene expression of Gata6, Tspan8, S100a8, and Lmo2 may act via novel pathways that play functionally important roles in Men1-associated tumor progression."
18591a24987
> "Q8BW41-1","RefSeq","NP_705768.4","24256719","AGO61-KO mice lacked laminin-binding glycans and exhibited phenotypes similar to those of known dystroglycanopathy mutants, as reflected by abnormalities in neural migration and basal lamina formation. Publication Status: Online-Only"
18593a24990,24992
> "Q9WVG9-1","RefSeq","NP_034962.2","28609438","Data show that complete removal of paternally expressed gene 3 (PEG3) resulted in up-regulation of male-specific lethal 1 (Msl1) and male-specific lethal 3 (Msl3). Publication Status: Online-Only"
> "Q9WVG9-1","RefSeq","NP_034962.2","21217699","Msl1 interacts with Msl3 as an extended chain forming an extensive hydrophobic interface, whereas the Msl1-MOF interface involves electrostatic interactions between the HAT domain and a long helix of Msl1."
> "Q9WVG9-1","RefSeq","NP_034962.2","11668396","Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice"
18601a25001,25003
> "Q922Y2-1","RefSeq","NP_080139.3","29467473","Trim59 may be a critical regulator for early embryo development from blastocyst stage to gastrula through modulating F-actin assembly. Publication Status: Online-Only"
> "Q922Y2-1","RefSeq","NP_080139.3","28820065","BCG increased membrane expression of TRIM59 through the TLR2/ TLR4/IRF5 pathway in RAW264.7 macrophage cell line."
> "Q922Y2-1","RefSeq","NP_080139.3","22949172","Trim59 might be an essential accessory molecule in mediating BCG-activated macrophages tumoricidal functions; and Trim59 is a phagocytosis-correlated molecule."
18605,18610d25006
< "Q9WVS8-1","RefSeq","NP_001277963.1","29723698","The data revealed that puerarin inhibited the monocyte adhesion in vitro and in vivo and thus reduced atherosclerotic lesions in apoE-/- mice; the protective effects were mediated by activation of ERK5/KLF2 signaling pathway."
< "Q9WVS8-1","RefSeq","NP_001277963.1","29986870","These findings highlight the importance of the Mek5-Erk5-Smurf-Smad-Sox9 axis in mammalian skeletogenesis. Publication Status: Online-Only"
< "Q9WVS8-1","RefSeq","NP_001277963.1","29159830","Extracellular-signal-regulated kinase 5 plays an essential role in the gestational augmentation of beta-cell proliferation."
< "Q9WVS8-1","RefSeq","NP_001277963.1","29038439","Novel role for Erk5 during bone maturation and homeostasis Publication Status: Online-Only"
< "Q9WVS8-1","RefSeq","NP_001277963.1","28887535","Erk5 role in the cardiac mitochondria and the Pgc-1alpha regulation Publication Status: Online-Only"
< "Q9WVS8-1","RefSeq","NP_001277963.1","12093914","Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects."
18631a25028,25033
> "Q810W6-1","RefSeq","NP_839972.1","27551720","CXCR1 and CXCR2 regulate hepatocyte exosome release. The mechanism utilized by CXCR1 remains elusive, but CXCR2 appears to modulate Nsm activity and resultant production of ceramide to control exosome release. CXCR1 is required for packaging of enzymes into exosomes that mediate their hepatocyte proliferative effect. Publication Status: Online-Only"
> "Q810W6-1","RefSeq","NP_839972.1","26950764","These studies define CXCR1 as a novel, noncanonical chemokine receptor that regulates pulmonary anti-Pseudomonas host defense with broad implications for cystic fibrosis, chronic obstructive pulmonary disease and other infectious lung diseases"
> "Q810W6-1","RefSeq","NP_839972.1","18059279","CXCR1 cleavage on neutrophils disables bacterial killing in cystic fibrosis lung disease"
> "Q810W6-1","RefSeq","NP_839972.1","17197447","CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8 in mouse"
> "Q810W6-1","RefSeq","NP_839972.1","16084593","The gene encoding mCXCR1-like was mapped to mouse chromosome 1 and its genomic organization was determined to be very similar to the organization of the gene encoding hCXCR1."
> "Q810W6-1","RefSeq","NP_839972.1","15967374","MCXCR1 may mediate the recruitment of neutrophils to the inflammation site under certain infections"
18632a25035,25037
> "Q5DID3-1","RefSeq","NP_803416.2","23190605","Overexpression of Umodl1 accelerates follicle depletion and subsequent ovarian degeneration. Publication Status: Online-Only"
> "Q5DID3-1","RefSeq","NP_803416.2","16026467","During embryonic development expression of the Umodl1 gene is detectable only in the olfactory epithelium and vomeronasal organ starting at embryonic day 16.5. suggest that olfactorin may play a role in correct olfactory axon navigation to the brain."
> "Q5DID3-1","RefSeq","NP_803416.2","15682396","At age 3 weeks, Umodl1 (N8) mRNA shows a smooth gradation from high apical to low basal within the layer of mature olfactory sensory neuron layer of the mouse olfactory epithelium.  Whether this is due to cell position or cell age is not known."
18645,18646c25050
< "P41438-1","RefSeq","NP_001186200.1","15579899","Existence of four unique noncoding exons and promoters for mRFC and demonstrate a facile induction of mRNAs for mRFC and multidrug resistance-associated proteins 1 and 3 in intestine in response to changes in dietary folate intake"
< "P41438-1","RefSeq","NP_001186200.1","12832086","Interaction between the E45 and K404 residues in the first and 11th transmembrane domains; the E45 residue appears to be the more dominant determinant of binding and anion sensitivity"
---
> "Q9DCJ7-1","RefSeq","NP_079614.1","17125467","There exists an Ub-independent alternative pathway that promotesAurora-A degradation and AURKAIP1 promotes Aurora-A degradation through this Ub-independent yet proteasome-dependent pathway."
18650,18651d25053
< "Q91YI4-1","RefSeq","NP_001258289.1","31270323","Mice lacking beta-arrestin-2 (barr2) selectively in adipocytes show significantly reduced adiposity and striking metabolic improvements when consuming excess calories. Publication Status: Online-Only"
< "Q91YI4-1","RefSeq","NP_001258289.1","30576947","Findings show that chemerin-activated CMKLR1 regulation in inflammatory macrophages is largely GRK6 and beta-arrestin mediated, which may impact innate immunity and have therapeutic implications in rheumatic disease."
18680a25083
> "Q9CQ26-1","RefSeq","NP_077201.1","21531206","These data suggest that AMSH plays an important role in degrading ubiquitinated proteins and glutamate receptors in vivo"
18687a25091
> "Q9WUC3-1","RefSeq","NP_035967.1","25716842","Ly6h regulates alpha7 nAChRs cell-surface expression and nicotine-induced potentiation of glutamatergic mEPSC."
18690,18695c25094,25097
< "Q8BIF0-1","RefSeq","NP_001186278.1","29791026","Conditional Tie-2-Cre driven gene inactivation of CD99L2 inhibits leukocyte entry into the CNS during active MOG35-55 -induced experimental autoimmune encephalomyelitis and alleviates severity of the disease. CD99L2 participates in the development of EAE by supporting diapedesis of leukocytes through the endothelial basement membrane of blood vessels of the BBB in the CNS."
< "Q8BIF0-1","RefSeq","NP_001186278.1","26321243","Mice lacking CD99L2 had a defective inflammatory response in the thioglycollate peritonitis model"
< "Q8BIF0-1","RefSeq","NP_001186278.1","23338758","The present study provides data for further investigation into the mCD99L2 gene in tumor cells."
< "Q8BIF0-1","RefSeq","NP_001186278.1","23293350","CD99L2 is an essential endothelial Ag for leukocyte extravasation, which does not require homophilic interactions with CD99L2 on leukocytes."
< "Q8BIF0-1","RefSeq","NP_001186278.1","18163232","Transfection of L cell fibroblasts with CD99L2 imparted to them the ability to adhere to each other in a divalent cation-dependent, homophilic manner. Anti-CD99L2 antibody blocked influx of neutrophils and monocytes into a site of inflammation in vivo."
< "Q8BIF0-1","RefSeq","NP_001186278.1","17344467","Expressed on mouse leukocytes and endothelial cells and is involved in transendothelial migration of neutrophils in vitro and in the recruitment of neutrophils into inflamed peritoneum"
---
> "Q9JI75-1","RefSeq","NP_064678.1","29526807","These data suggest that the overexpression of QR2 in brain cells in the presence of catechol quinones might lead to reactive oxygen species-induced cell death via the rapid conversion of superoxide radicals into hydrogen peroxide and then into highly reactive hydroxyl radicals"
> "Q9JI75-1","RefSeq","NP_064678.1","24142791","NQO2 stabilization of C/EBPalpha was independent of NQO1, even though both interacted with the same C/EBPa domain."
> "Q9JI75-1","RefSeq","NP_064678.1","23554006","Melatonin, acting at least partially via MT2 receptors, can regulate the redox status of quinone reductase II inhibited preadipocytes."
> "Q9JI75-1","RefSeq","NP_064678.1","12351651","Role for NQO2 in protection against myelogenous hyperplasia and in metabolic activation of menadione, leading to hepatic toxicity"
18699a25102,25106
> "Q8CBR1-1","RefSeq","NP_598870.1","28461473","In cultured renal epithelial cells normally lacking the expression of Ildr1, overexpression of Ildr1 significantly reduces the paracellular water permeability. Together, study provides a mechanism of how cells transport water."
> "Q8CBR1-1","RefSeq","NP_598870.1","25822906","The angulin-2/ILDR1 deficiency causes the postnatal degenerative loss of hair cells in the cochlea. Publication Status: Online-Only"
> "Q8CBR1-1","RefSeq","NP_598870.1","25217574","Study consolidate the importance of ILDR1 as a tight junction protein necessary for cochlear hair cells survival, and the integrity of the auditory system."
> "Q8CBR1-1","RefSeq","NP_598870.1","23863714","ILDR1 regulates CCK release through a mechanism dependent on fatty acids and lipoproteins."
> "Q8CBR1-1","RefSeq","NP_598870.1","23239027","The findings show the heterogeneity of the molecular organization of tTJs in terms of the content of LSR, ILDR1 or ILDR2, and suggest that ILDR1-mediated recruitment of tricellulin to TCs is required for hearing. Erratum:[J Cell Sci. 2013 Aug 15;126(Pt 16):3797]"
18705c25112,25118
< "Q8C167-1","RefSeq","NP_001157094.1","23321636","The data demonstrate PREPL as an AP-1 effector that takes part in the regulation of AP-1 membrane binding. PREPL is highly expressed in brain and at lower levels in muscle and kidney."
---
> "Q921H8-1","RefSeq","NP_570934.1","15043762","Molecular cloning, gene structure and tissue distribution of 3-ketoacyl-CoA thiolase A. Publication Status: Online-Only"
> "O88838-1","RefSeq","NP_038567.1","28270450","Collectively, Ssb1 and Ssb2 control crucial aspects of Hematopoietic stem and progenitor cells function, including proliferation and survival in vivo by resolving replicative stress to maintain genomic stability."
> "O88838-1","RefSeq","NP_038567.1","20561531","Structural changes limit high-affinity interactions for SPSB2 to aspartate-containing sequences"
> "O88838-1","RefSeq","NP_038567.1","20603330","The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation."
> "O88838-1","RefSeq","NP_038567.1","17088318","Backbone dynamics of SSB-2 by means of Modelfree analysis."
> "O88838-1","RefSeq","NP_038567.1","16369487","Determined the first SPRY-domain structure of SSB-2 that adopts a novel fold and contains conserved structural determinants for binding to prostate apoptosis response protein-4 (PAR-4)."
> "O88838-1","RefSeq","NP_038567.1","15964819","Genetic deletion of SOCS Box Protein 2 results in a very mild thrombocytopenia."
18707,18713d25119
< "Q8R1X6-1","RefSeq","NP_001138459.1","28324774","Findings evidence a positive correlation between SIRT1 and BCL6 expression increase in follicular lymphomas (FL) . SIRT1 methylation decreases in FL and diffuse large-B cell lymphomas (DLBCL)and this parallels the increase of KLF4, DAPK1 and SPG20 methylation"
< "Q8R1X6-1","RefSeq","NP_001138459.1","27112432","Here we report the case of three patients of Filipino descent with Troyer syndrome. Whole exome sequencing (WES) identified a homozygous mutation c.364_365delAT which predicts p.Met122Valfs*2 in SPG20"
< "Q8R1X6-1","RefSeq","NP_001138459.1","24523286","Spartin, via the ubiquitin-binding region, binds Lys-63-linked ubiquitin chains but does not bind Lys-48-linked ubiquitin chains.  spartin's role in DALIS formation depends on key residues within its ubiquitin-binding region."
< "Q8R1X6-1","RefSeq","NP_001138459.1","22982304","Alsin and spartin may interact each other physically"
< "Q8R1X6-1","RefSeq","NP_001138459.1","22619377","A role for spartin in lipid droplets maintenance and in the regulation of cytokinesis"
< "Q8R1X6-1","RefSeq","NP_001138459.1","21559443","SPG20 protein spartin associates with cardiolipin via its plant-related senescence domain and regulates mitochondrial Ca2+ homeostasis Publication Status: Online-Only"
< "Q8R1X6-1","RefSeq","NP_001138459.1","16036216","Our results suggest that spartin might be involved in endocytosis, vesicle trafficking, or mitogenic activity, and that impairment in one of these processes may underlie the long axonopathy in patients with Troyer syndrome."
18736a25143,25147
> "Q9QYS9-1","RefSeq","NP_068681.1","30628007","This initial screen isolated two potential Emx2-binding partner proteins, Cnot6l and QkI-7. These novel Emx2-binding proteins are involved in multiple levels of mRNA metabolism that including splicing, mRNA export, translation, and destruction"
> "Q9QYS9-1","RefSeq","NP_068681.1","29133306","Overexpression of Qki5 strongly attenuates the toxic effect of doxorubicin via regulating cardiac circular RNAs."
> "Q9QYS9-1","RefSeq","NP_068681.1","29021242","This study explores how levels of two isoforms, nuclear Quaking-5 (Qk5) and cytoplasmic Qk6, are regulated in mouse myoblasts. Qk5 and Qk6 proteins have distinct functions in splicing and translation, respectively, enforced through differential subcellular localization."
> "Q9QYS9-1","RefSeq","NP_068681.1","29021239","These data collectively indicate that Qki5 regulates communication between neural stem cells by mediating numerous RNA processing events and suggest new links between splicing regulation and neural stem cell states."
> "P52187-1","RefSeq","NP_001254522.1","17640933","Kir2 channels exist in two states having different susceptibilities to internal cationic blockers"
18739a25151
> "P48540-1","RefSeq","NP_034405.1","30651543","Study utilizing mouse kidney cultures and time-lapse imaging provided quantitative experimental support that a ligand-receptor-based Turing mechanism, implemented via GDNF-RET signaling, specifies the areas of outgrowth during kidney branching morphogenesis. The positive feedback between GDNF and WNT11 enables the dense packing of the ureteric buds. Publication Status: Online-Only"
18751a25164,25166
> "P37242-1","RefSeq","NP_033406.1","29753845","Data suggest that gestational/maternal endocrine disruptor DEHP [di-(2-ethylhexyl) phthalate] exposure dose-dependently causes fetal IUGR (intrauterine growth restriction); mRNA levels of placental Thra1 and Thrb1 are reduced and nuclear translocation of placental Thra1 and Thrb1 is suppressed in DEHP-exposed mice."
> "P37242-1","RefSeq","NP_033406.1","29895698","Thyroid hormone receptor beta1 stimulates ABCB4 to increase biliary phosphatidylcholine excretion"
> "P37242-1","RefSeq","NP_033406.1","29945885","Transcriptome and ChIP-seq analyses and found that many genes that were co-regulated by both THRB1 and ESRRA were involved in mitochondrial metabolic pathways. Publication Status: Online-Only"
18753d25167
< "Q91YP6-1","RefSeq","NP_001240621.1","22177965","The data demonstrate the ability of the SH3 domain of DOCK180 to interact with ELMO1, regardless of the presence of the polyproline-containing C-terminal end."
18758a25173,25176
> "Q9JJ57-1","RefSeq","NP_081674.2","20678225","KChIP1 is a synaptic protein that regulates behavioral anxiety by modulating inhibitory synaptic transmission. Publication Status: Online-Only"
> "Q9JJ57-1","RefSeq","NP_081674.2","17640927","Aromatic cluster in exon1b modulates the transitions towards and from the closed inactivated states and the steady state distribution over the respective states"
> "Q9JJ57-1","RefSeq","NP_081674.2","15363885","KChIP1 was expressed in a subpopulation of neurons widely distributed in brain and enriched in Purkinje cells of the cerebellum and in the reticular thalamic and medial habenular nuclei."
> "Q9JJ57-1","RefSeq","NP_081674.2","14572458","Differential expression of KCh1P1 splice variants can shape the function of Kv4.2 channels involved in protection against back propagating action potentials in dendritic spines."
18762a25181
> "Q0P5Y3-1","RefSeq","NP_001122106.1","18424439","Foxo3 represses ROS in part via regulation of ATM and this repression is required for maintenance of the hematopoietic stem cell pool"
18765a25185,25192
> "Q8BVK9-1","RefSeq","NP_780606.3","27858493","Using mouse models and genetic characteristics of human patients the role of SP110b was studied to determine its role in controlling host immunity and susceptibility to TB by modulating nuclear factor-kappaB (NF-kappaB) activity resulting in down regulation of TNF-alpha production and upregulation of NF-kappaB-induced antipoptotic gene expression suppressing IFN-gamma-mediated monocyte and/or macrophage cell death."
> "Q8BVK9-1","RefSeq","NP_780606.3","27622275","Mechanistic studies revealed that an arginine/lysine-rich element within the DNA-binding domain (SAND domain) is critical for Ipr1 binding to the importin protein receptor NPI-1, demonstrating that this element plays an essential role in mediating the nuclear localization of Ipr1 protein Publication Status: Online-Only"
> "Q8BVK9-1","RefSeq","NP_780606.3","26912204","These findings not only reveal the transcriptional basis of Sp110-mediated macrophage resistance to Mtb, but also suggest potential regulatory roles for Sp110 related to inflammatory responses, miRNA profiles, and the intracellular growth of Mtb. Publication Status: Online-Only"
> "Q8BVK9-1","RefSeq","NP_780606.3","26590945","Strain-specific promoter region polymorphism is associated with resistance to tuberculosis"
> "Q8BVK9-1","RefSeq","NP_780606.3","21790702","Mediates RAW 264.7 macrophage cell line resistance to Mycobacterium bovis"
> "Q8BVK9-1","RefSeq","NP_780606.3","20221700","Ipr1 might be involved in apoptosis pathway via MYBBP1A."
> "Q8BVK9-1","RefSeq","NP_780606.3","15815631","Data indicate that the Ipr1 gene product might have a previously undocumented function in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death and pathogenesis"
> "Q8BVK9-1","RefSeq","NP_780606.3","11471051","Identification and analysis of the genes Sp100, Csprs, and Ifi75 in two members of the genus Mus, M. musculus and M. caroli"
18768a25196,25199
> "Q3TDN0-1","RefSeq","NP_081142.3","29359685","The results showed that a protein called Furin activates Dispatched by splitting it at a specific point. When the break-point on Dispatch was genetically modified, Furin could no longer cleave the protein. As a consequence, Dispatched did not reach the correct location within cells to help Hedgehog move away from signal-releasing cells. Publication Status: Online-Only"
> "Q3TDN0-1","RefSeq","NP_081142.3","18395198","Disp1 regulates growth of mammalian long bones through the control of Indian hedgehog distribution."
> "Q3TDN0-1","RefSeq","NP_081142.3","12421714","Disp is required for the movement of Hh protein from its sites of synthesis in mice"
> "Q3TDN0-1","RefSeq","NP_081142.3","12372258","Shh signaling is required within the notochord to maintain Shh expression and to prevent notochord degeneration. Disp1, unlike Smo, is not required for this juxtacrine signaling by Shh."
18784a25216,25218
> "Q80U16-1","RefSeq","NP_848773.3","30254631","Results show that Fam65b expression and phosphorylation can finely tune the amount of active RhoA in order to favor optimal T lymphocyte motility. Publication Status: Online-Only"
> "Q80U16-1","RefSeq","NP_848773.3","27269051","RhoC co-localizes with Fam65b in stereocilia and regulates Fam65b oligomerization what is critical for hair cell function. Publication Status: Online-Only"
> "Q80U16-1","RefSeq","NP_848773.3","25588844","These data together elucidate a mechanism for RHOA and pMLC polarization in stimulated neutrophils through direct inhibition of RHOA by FAM65B at the leading edge."
18788a25223,25233
> "Q8CBW3-1","RefSeq","NP_031406.2","30213875","This study shows that bone marrow-specific deletion of Abi1 in a novel mouse model leads to development of an myeloproliferative neoplasms-like phenotype resembling human primary myelofibrosis. Abi1 loss resulted in a significant increase in the activity of the Src family kinases (SFKs), STAT3, and NF-kappaB signaling."
> "Q8CBW3-1","RefSeq","NP_031406.2","26428302","The expression of NESH/Abi-3 caused degradation of endogenous Abi-1, which led to the formation of a NESH/Abi-3-based WAVE2 complex. Publication Status: Online-Only"
> "Q9Z2J6-1","RefSeq","NP_034092.1","31151773","Our study revealed that rising temperature of POA alters the activity of Ptgds-expressing neurons so as to increase PGD2 production. Erratum:[Neuron. 2019 Jul 17;103(2):349. PMID: 31319050]"
> "Q9Z2J6-1","RefSeq","NP_034092.1","29970474","These results demonstrate the critical role of CRTH2-mediated Th2 response in Pulmonary arterial hypertension pathogenesis."
> "Q9Z2J6-1","RefSeq","NP_034092.1","29743346","The beneficial effects of DP2 blockade or DP1 agonism were associated with increased interferon-lambda (IFN-lambda) [interleukin-28A/B (IL-28A/B)] expression and were lost upon IL-28A neutralization."
> "Q9Z2J6-1","RefSeq","NP_034092.1","29335338","These findings revealed an unexpected role of CRTH2 in promoting endoplasmic reticulum stress-induced cardiomyocyte apoptosis."
> "Q9Z2J6-1","RefSeq","NP_034092.1","28623133","Prostaglandin D2 suppressed the lipolysis by repression of the cAMP-PKA-hormone-sensitive lipase axis through CRTH2 in adipocytes."
> "Q9Z2J6-1","RefSeq","NP_034092.1","16030019","Analysis of prostaglandin D2 receptor CRTH2 determinants of ligand binding affinity and selectivity"
> "Q9Z2J6-1","RefSeq","NP_034092.1","15563582","CRTH2 can be activated by indomethacin, a nonselective cyclooxygenase inhibitor and widely used nonsteroidal anti-inflammatory drug (NSAID)."
> "Q9Z2J6-1","RefSeq","NP_034092.1","15065763","CRTH2 protein structure and expression (review) Review article"
> "Q9Z2J6-1","RefSeq","NP_034092.1","12878180","Gene structure and functional properties of CRTH2, a prostaglandin D2 receptor."
18802a25248,25249
> "P13346-1","RefSeq","NP_032062.1","29408867","Study provides key insights into functional domains regulated by FosB in the hippocampus, emphasizing remarkably different programs of gene regulation under physiological and pathological conditions Publication Status: Online-Only"
> "P13346-1","RefSeq","NP_032062.1","29181403","These findings suggest that GosB may regulate mammary epithelial cells milk fat synthesis and apoptosis via PPARgamma in mouse mammary glands."
18821,18826c25268,25280
< "Q60819-1","RefSeq","NP_032384.1","30926899","Data reveal a critical function of Shp-2 as a molecular nexus bridging acute IL-15 signaling with downstream metabolic burst and NK cell expansion. Publication Status: Online-Only"
< "Q60819-1","RefSeq","NP_032384.1","29676596","IL-15 is a particularly important regulator of natural killer development, differentiation, homeostasis, and activation."
< "Q3UWA6-1","RefSeq","NP_001120790.1","30642983","This retrogenic model can be employed to define self-tolerance mechanisms restricting T and B cell responses to GUCY2C to optimize colorectal cancer immunotherapy without autoimmunity."
< "Q3UWA6-1","RefSeq","NP_001120790.1","29367634","Relative to controls, guanylate cyclase C knockout mice develop severe systemic illness following oral Salmonella infection, characterized by disrupted intestinal mucus layer, elevated cytokines and organ bacterial load, and reduced animal survival. Publication Status: Online-Only"
< "Q3UWA6-1","RefSeq","NP_001120790.1","28916678","Loss of Gucy2c expression is associated with Acute Radiation-Induced GI Syndrome."
< "Q3UWA6-1","RefSeq","NP_001120790.1","26773096","Findings show how caloric suppression of the guanylin-GUCY2C signaling axis links obesity to negation of a universal tumor suppressor pathway in colorectal cancer."
---
> "Q3UBX0-1","RefSeq","NP_598903.1","28630041","Data, including data from studies in vesicles of knockout mice, suggest pathophysiological levels of Zn2+ (>2nM) cause dysregulation of RyR2 opening; in sarcoplasmic reticulum, RyR2 are not the only Ca2+-channels regulated by Zn2+; in cardiomyocytes exposed to ischemic/hypoxic conditions, intracellular Zn2+ levels are elevated, coinciding with increased MG23 expression. (RyR2 = ryanodine receptor 2; MG23 = mitsugumin 23)"
> "Q3UBX0-1","RefSeq","NP_598903.1","23542032","MG23 plays a protective role against UVC by accumulating alphaBC in the close vicinity of the ER"
> "Q3UBX0-1","RefSeq","NP_598903.1","20060811","MG23 is an essential component of ER-generated lethal signals provoked upon DNA damage, specifying cell fate under pathophysiological conditions."
> "Q8VDL9-1","RefSeq","NP_112461.2","29371181","Ring1A/B regulate and maintain AML stem cells in part by repressing Glis2 expression, which promotes their differentiation."
> "Q8VDL9-1","RefSeq","NP_112461.2","27181777","Kif3a is required for cell cycle regulation and the DNA damage response, whereas cell senescence is significantly enhanced in Glis2 null cells."
> "Q8VDL9-1","RefSeq","NP_112461.2","21127075","Glis2 can function as a transcriptional activator and that post-translational modification within its DNA-binding domain can regulate its transcriptional activity"
> "Q8VDL9-1","RefSeq","NP_112461.2","11741991","Characterization of Glis2, a novel gene encoding a Gli-related, Kruppel-like transcription factor with transactivation and repressor functions"
> "Q8VDL9-1","RefSeq","NP_112461.2","11262234","Positive regulator of neuronal differentiation"
> "P62956-1","RefSeq","NP_573452.3","25583485","Thus, gamma-7 is capable of supporting a component of excitatory transmission in PCs, sufficient to maintain essentially normal motor behavior, in the absence of gamma-2."
> "P62956-1","RefSeq","NP_573452.3","23872597","The results of this study suggested that TARPed synaptic receptors in granule cells require both gamma-2 and gamma-7 and reveal an unexpected basis for the loss of AMPAR-mediated transmission in stargazer mice."
> "P62956-1","RefSeq","NP_573452.3","21172611","TARP gamma-7 causes AMPA receptors to 'resensitize' upon continued glutamate application."
> "P62956-1","RefSeq","NP_573452.3","20529126","Results suggest that TARPs gamma-2 and gamma-7 cooperatively promote synaptic expression of cerebellar AMPA receptors, and the latter also promotes glial expression."
> "P62956-1","RefSeq","NP_573452.3","17475805","Gamma-7 is a new member of the transmembrane AMPA receptor regulatory protein (TARP) family that can differentially influence AMPA receptors in cerebellar neurons. (TARP gamma-7)"
18844a25299,25304
> "Q9ET39-1","RefSeq","NP_109635.1","29305520","Authors found that seSLAMF6 reduced activation-induced cell death and had an antiapoptotic effect on tumor-infiltrating lymphocytes."
> "Q9ET39-1","RefSeq","NP_109635.1","28904129","Naive T cells regulate B cell survival in a SLAMF6-dependent manner"
> "Q9ET39-1","RefSeq","NP_109635.1","28373584","In addition to its established role in Invariant NKT(iNKT) cell ontogeny, Ly108 regulates iNKT cell function in mice and humans"
> "Q9ET39-1","RefSeq","NP_109635.1","27223891","CRISPR-Mediated Slamf1Delta/Delta Slamf5Delta/Delta Slamf6Delta/Delta Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects. Publication Status: Online-Only"
> "Q9ET39-1","RefSeq","NP_109635.1","26878112","In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'."
> "Q9ET39-1","RefSeq","NP_109635.1","15879084","Following targeted disruption of the LY108 gene, CD4+ T cell and innate responses are defective; a surprising role for Ly108 is revealed in the control of responses to bacteria by neutrophils, while macrophage functions are intact."
18849a25310,25311
> "B2RPY5-1","RefSeq","NP_001297359.1","29386106","Gpr161 restricts cerebellar granule cell progenitor production by preventing premature and sonic hedgehog-dependent pathway activity, highlighting the importance of basal pathway suppression in tumorigenesis"
> "B2RPY5-1","RefSeq","NP_001297359.1","29222391","Gpr161 promotes forelimb formation, regulates limb patterning, prevents periarticular chondrocyte proliferation and drives osteoblastogenesis in intramembranous bones in a cilium-dependent manner. Publication Status: Online-Only"
18857a25320,25321
> "Q80ZE4-1","RefSeq","NP_082271.1","24269738","Paqr7 and Paqr8 are expressed in the midbrain ventral tegmental area of proestrous mice."
> "Q9R1K7-1","RefSeq","NP_062730.1","29290584","Loss-of-function mutations in Tubd1 prevent cells from assembling primary cilia and consequently lead to the failure to respond to Hedgehog ligands. Erratum:[Dev Cell. 2018 Jan 22;44(2):271. PMID: 29401421]"
18860a25325
> "A2A9F4-1","RefSeq","NP_598468.2","24075906","The Keratinocyte differentiation factor 1 is an essential regulator of the proliferation-differentiation balance in epidermal progenitor cells."
18868a25334
> "Q3UQA7-1","RefSeq","NP_001032356.1","29535592","Overexpression of selenoprotein H can protect cells from glutamate toxicity by preserving mitochondrial morphology and suppressing autophagy. Publication Status: Online-Only"
18874a25341,25345
> "Q7TMK9-1","RefSeq","NP_062770.1","28436985","SYNCRIP is required to maintain myeloid leukemia survival."
> "Q7TMK9-1","RefSeq","NP_062770.1","27732855","SYNCRIP (synaptotagmin-binding cytoplasmic RNA-interacting protein; also known as hnRNP-Q or NSAP1) is a component of the hepatocyte exosomal miRNA sorting machinery."
> "Q7TMK9-1","RefSeq","NP_062770.1","27392095","HnRNP Q binds to mCry1 mRNA via the 5'UTR. Furthermore, hnRNP Q inhibits the translation of mCry1 mRNA, leading to altered rhythmicity in the mCRY1 protein profile. Publication Status: Online-Only"
> "Q7TMK9-1","RefSeq","NP_062770.1","26658614","HnRNP-Q1-mediated repression of Gap-43 mRNA translation provides an additional mechanism for regulating GAP-43 expression and function and may be critical for neuronal development."
> "Q7TMK9-1","RefSeq","NP_062770.1","11994298","Identification of the tyrosine phosphorylated form"
18882a25354,25361
> "P70458-1","RefSeq","NP_766541.2","25000564","Role of PCI not only for the function and/or maturation of macrophages, but also as a negative regulator of apoptotic cell and activated platelets removal Publication Status: Online-Only"
> "P70458-1","RefSeq","NP_766541.2","20229239","The expression pattern of PCI throughout mouse development was mapped using in situ hybridization and immunohistochemistry."
> "P70458-1","RefSeq","NP_766541.2","18000606","The reactions with thrombin or APC of recombinant alpha(1)-PI M358R variants with or without the HCII extension were characterized electrophoretically and kinetically"
> "P70458-1","RefSeq","NP_766541.2","17434507","In testes of wild type males PCI is detected in spermatocytes of prophase I, as well as in late spermatids and mature spermatozoa, but it is absent from somatic cells."
> "E9Q9K8-1","RefSeq","NP_932779.2","26563778","Findings indicate a interplay between A-kinase anchoring protein 6 (AKAP6) and myogenin. Publication Status: Online-Only"
> "E9Q9K8-1","RefSeq","NP_932779.2","26844267","These results identify mAKAPalpha as a scaffold for signaling in the stressed neuron that is required for RGC neuroprotection after optic nerve injury. Publication Status: Online-Only"
> "E9Q9K8-1","RefSeq","NP_932779.2","19574217","The association of AC5 with the AKAP6 complex is required for the regulation of cAMP second messenger controlling cardiac myocyte hypertrophy."
> "E9Q9K8-1","RefSeq","NP_932779.2","16337591","Two alternatively spliced forms of mAKAP are expressed: mAKAPalpha, the longer form, and mAKAPbeta. mAKAPalpha is preferentially expressed in brain"
18884a25364,25367
> "Q8C0N0-1","RefSeq","NP_808374.1","15289607","First described as a mouse-specific duplication of the MARK kinase family, and named as MarkmA1."
> "Q8VDP4-1","RefSeq","NP_666167.3","30415949","Insulin acutely regulates SIRT1 activity by triggering recruitment of PACS-2 and DBC1 to the SIRT1 N terminal region creating a regulatory hub."
> "Q8VDP4-1","RefSeq","NP_666167.3","26378077","Phosphorylation of DBC1 at its C terminus by IKKalpha facilitates its interaction with RelB and IKKalpha, indicating that DBC1-mediated suppression of alternative NF-kappaB is regulated by IKKalpha."
> "Q8VDP4-1","RefSeq","NP_666167.3","26074075","Dbc1 ablation increases Scd1 levels, causes obesity and insulin resistance."
18887a25371
> "Q80ZE5-1","RefSeq","NP_083105.3","24269738","Paqr7 and Paqr8 are expressed in the midbrain ventral tegmental area of proestrous mice."
18902,18903d25385
< "Q80YA3-1","RefSeq","NP_001271328.1","30221923","DDHD1 is a principal regulator of bioactive lysophosphatidylinositol lipids and other lysophospholipids, as well as phosphatidylinositol phosphates, in the mammalian nervous system, pointing to a potential role for these lipid pathways in hereditary spastic paraplegia"
< "Q80YA3-1","RefSeq","NP_001271328.1","24599962","A possible mechanism of PA regulation of the mitochondrial membrane and demonstrate an in vivo function of PA-PLA1 in the organization of mitochondria during spermiogenesis."
18907a25390
> "Q9QYN3-1","RefSeq","NP_064358.1","28867182","Together, our results suggest that KLF4 regulates asthma development in a TSLP- and fibrocyte-dependent manner."
18909d25391
< "Q11131-1","RefSeq","NP_001170837.1","27591321","The DNA demethylation within the fut7 gene controls selectin ligand expression in mice, including the inducible topographic commitment of T cells for skin and inflamed sites."
18914a25397,25398
> "Q6P1D5-1","RefSeq","NP_064366.2","27716410","Study demonstrates that SEZ6 and SEZ6L are physiological BACE1 substrates in the murine brain and suggests that sSEZ6 and sSEZ6L levels in CSF are suitable markers to monitor BACE1 inhibition in mice Publication Status: Online-Only"
> "P97718-1","RefSeq","NP_038489.2","29566737","Thinner media and lower alpha1-adrenoceptor expression weaken contractions of breast cancer feed arteries in response to sympathetic activity. We propose that abnormalities in breast cancer arteries can be exploited to modify tumor perfusion and thereby either starve cancer cells or facilitate drug and oxygen delivery during chemotherapy or radiotherapy. Publication Status: Online-Only"
18917a25402
> "Q6NXL1-1","RefSeq","NP_081411.2","23596517","SEC24D is absolutely required for early embryonic development in the mouse, with complete deficiency resulting in uniform loss prior to the blastocyst stage. Publication Status: Online-Only"
18937a25423
> "Q61024-1","RefSeq","NP_036185.1","24292060","Asns is involved in the regulation of plasma glucose levels."
18954,18957c25440
< "E9Q5C9-1","RefSeq","NP_001034441.1","28493459","Enhanced NOLC1 promotes cell senescence and represses hepatocellular carcinoma cell proliferation by disturbing the organization of nucleolus."
< "E9Q5C9-1","RefSeq","NP_001034441.1","26984997","UBF and Nopp140 dynamic redistribution between the two-cell and blastocyst stages (time of implantation) is correlated with morphological and structural modifications that occur in embryonic nucleolar compartments."
< "Q80XG9-1","RefSeq","NP_001334190.1","23911104","This study demonistrated that LRRTM4-HSPG complex mediates excitatory synapse development on dentate gyrus granule cells."
< "Q99P30-1","RefSeq","NP_077757.2","18799520","Data suggest that NUDT7alpha function is tightly linked to peroxisomal CoASH/acyl-CoA homeostasis."
---
> "Q8BX90-1","RefSeq","NP_997519.2","16904100","Models are presented for the function of FNDC3A in mediating spermatid-Sertoli adhesion during mouse spermatogenesis."
18970,18972c25453,25457
< "Q9R1X4-1","RefSeq","NP_001157553.1","25448545","The obtained results suggest that Tim is expressed in neuronal tissues in a spatiotemporally regulated manner and involved in developmental stage-specific neuronal functions."
< "Q9R1X4-1","RefSeq","NP_001157553.1","23266470","The Phosphorylation of timeless protein by Hck and Fyn induced Tim ubiquitylation on K48 and subsequent degradation, while c-Src and c-Yes led to K63-linked ubiquitylation and Tim accumulation within cells."
< "Q9R1X4-1","RefSeq","NP_001157553.1","23418588","Data indicate that RNAi-mediated knockdown of TIMELESS (TIM) in NIH3T3 and U2OS cells shortens the period by 1 hour and diminishes DNA damage-dependent phase advancing."
---
> "P42208-1","RefSeq","NP_035021.1","27155525","The results showed that SEPT2 has an oncogenic function through accelerated cell proliferation and invasion in biliary tract cancers, and is negatively regulated by miR-140-5p."
> "P42208-1","RefSeq","NP_035021.1","27551056","Septins regulate fluid-phase cargo traffic to lysosomes by promoting macropinosome maturation and fusion with endosomes/lysosomes."
> "P42208-1","RefSeq","NP_035021.1","25575596","Results indicate a stimulatory role of septin-2 and the dynamic reorganization of septin oligomers in exocytosis."
> "Q8C879-1","RefSeq","NP_109638.2","23469003","Znf202 overexpression in vivo reveals an important role of this transcriptional regulator in liver lipid homeostasis, while firmly establishing the proposed key role in the control of HDL levels"
> "Q8C879-1","RefSeq","NP_109638.2","18523156","SOX17-Chromatin immunoprecipitation identified zinc finger protein 202 (Zfp202) as a direct target of SOX17 during endoderm differentiation of F9 embryonal carcinoma cells."
18979a25465,25467
> "P23299-1","RefSeq","NP_032450.1","28743749","SUMOylation of KCNQ1 is KCNE1 dependent and determines the native attributes of cardiac IKs in vivo."
> "P23299-1","RefSeq","NP_032450.1","26410412","KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation Review article"
> "P23299-1","RefSeq","NP_032450.1","26454161","The electrophysiological effects of BACE1 on KCNQ1 reported here were independent of its enzymatic activity."
18992d25479
< "P97765-1","RefSeq","NP_058548.1","21642474","This study established WBP2 as a tyrosine phosphorylation target of estrogen signaling via EGFR crosstalk."
19001a25489,25491
> "Q8BHJ7-1","RefSeq","NP_795916.1","30282698","Both total GABAA and GABAA alpha5 receptor availability in two positron emission tomography imaging studies, are reported."
> "Q8BHJ7-1","RefSeq","NP_795916.1","30177704","Nonlinear-rectifying alpha5-GABAARs with slow kinetics match functional NMDA-receptor properties and thereby mediate powerful control of dendritic postsynaptic integration and action potential firing by dendrite-targeting interneurons. Publication Status: Online-Only"
> "Q8BHJ7-1","RefSeq","NP_795916.1","28717969","These results provide further evidence of the role of GABAA alpha5 receptor-mediated inhibition in cognitive impairment in the TS mouse model of Down syndrome."
19007,19008c25497
< "A2ALU4-1","RefSeq","NP_001277613.1","21248203","Data suggest that Shroom2 facilitates the formation of a contractile network within endothelial cells, the loss of which leads to an increase in endothelial sprouting, migration, and angiogenesis."
< "A2ALU4-1","RefSeq","NP_001277613.1","17666436","Shroom2 and ZO-1 form a tight-junction-associated scaffolding complex, possibly linked to myosin VIIa, that bridges the junctional membrane to the underlying cytoskeleton, thereby contributing to the stabilization of these junctions."
---
> "Q8VCH9-1","RefSeq","NP_666164.1","24692514","Lrrc3b expression is directly and rapidly increased by odor stimulation of mouse olfactory sensory neurons. [Lrrc3b]"
19013,19020c25502,25505
< "Q9D411-1","RefSeq","NP_081949.1","26940607","Phosphorylated Tssk4 might participate in testis genes expressions by phosphorylating Crem at Ser-117."
< "Q9D411-1","RefSeq","NP_081949.1","26961893","Testis-specific serine/threonine protein kinase 4 (Tssk4) phosphorylates Odf2 at Ser-76 Publication Status: Online-Only"
< "Q9D411-1","RefSeq","NP_081949.1","23599433","HSP90 function abolished the catalytic activities of TSSK4 and -6 but did not significantly alter the specific activities of TSSK1 and -2. Inhibition of HSP90 resulted in increased TSSK ubiquitination and proteasomal degradation"
< "Q9D411-1","RefSeq","NP_081949.1","23054012","Autophosphorylation at Thr-197 plays a critical role in maintaining Tssk4 kinase activity, which might be involved in spermiogenesis."
< "Q3TZM9-1","RefSeq","NP_001230090.1","25036826","Hence, we concluded that there is different transcriptional control mechanism between mALG11 and hALG11"
< "P30999-1","RefSeq","NP_001078919.1","29875160","This study concluded that by undergoing cleavage, delta-catenin differentially regulates the densities of subpopulations of dendritic spines and contributes to proper neural circuit wiring in the developing brain."
< "P30999-1","RefSeq","NP_001078919.1","29923340","In the present study, we generated a conditional knockout mouse model and examined epidermal proliferation, differentiation and permeability. The results showed that conditional knockout of p120 in the epidermis caused not only increased epidermal proliferation but also decreased epidermal differentiation and increased permeability"
< "P30999-1","RefSeq","NP_001078919.1","29130932","P120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia."
---
> "O08605-1","RefSeq","NP_067436.1","27413184","Data suggest a physiological role for MNK1a-Ser(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E phosphorylation in vitro and in vivo."
> "O08605-1","RefSeq","NP_067436.1","23269249","Mnk1/2 has a minimal role in T cell development and activation but may regulate non-T cell lineages to control Th1 and Th17 differentiation in vivo."
> "O08605-1","RefSeq","NP_067436.1","15234964","Mnk1 phosphorylation by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk"
> "O08605-1","RefSeq","NP_067436.1","15254222","Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development"
19037a25523
> "Q8CG46-1","RefSeq","NP_722503.1","28302748","Age-dependent depletion of the SMC5/6 complex in oocytes could contribute to increased incidence of oocyte aneuploidy and spontaneous abortion in aging females."
19038a25525,25527
> "Q8K019-1","RefSeq","NP_722482.1","29466738","Myogenic differentiation is achieved through the specific interaction between Cry2 and Bclaf1, which stabilizes mRNAs encoding cyclin D1, a G1/S phase transition regulator, and Tmem176b, a transmembrane regulator for myogenic cell fusion."
> "Q8K019-1","RefSeq","NP_722482.1","28120329","Constitutive expression of the anti-apoptotic molecule Bfl1 (A1) in murine vascular Endothelial Cells leads to prolonged allograft survival due to modifying inflammation."
> "Q8K019-1","RefSeq","NP_722482.1","24453340","Bclaf1 facilitates the differentiation of early retinal precursors into retinal ganglion cells, amacrine cells, and horizontal cells rather than into cone photoreceptors."
19043a25533,25536
> "Q3UN16-1","RefSeq","NP_038561.1","25275856","GPR162 is widely expressed in GABAergic as well as other neurons within the mouse hippocampus, whereas extensive expression is observed in areas related to energy homeostasis and hedonic feeding such as hypothalamus, amygdala and ventral tegmental area"
> "Q91WM6-1","RefSeq","NP_663545.2","28044434","ATP synthesis, oxidative phosphorylation, and the TCA cycle, are involved in the EVA1A regulatory network.EVA1A plays an important role in neuronal differentiation."
> "Q91WM6-1","RefSeq","NP_663545.2","28151473","Eva1a improves cardiac function. Publication Status: Online-Only"
> "Q91WM6-1","RefSeq","NP_663545.2","26905199","EVA1A deletion results in defective self-renewal and differentiation of NSCs.  EVA1A modulates autophagy through the PIK3CA/AKT-mTOR pathway."
19047a25541,25548
> "Q9DBX2-1","RefSeq","NP_080452.2","29290584","Pdcl has been implicated as a positive regulator of Hedgehog signaling that may control the trafficking of signaling receptors to primary cilia. Erratum:[Dev Cell. 2018 Jan 22;44(2):271. PMID: 29401421]"
> "Q9DBX2-1","RefSeq","NP_080452.2","25659125","Findings reveal a common mechanism of Gbetagamma and RGS9-Gbeta5 assembly in rods and cones, highlighting the importance of PhLP1 and CCT-mediated Gbeta complex formation in G protein signaling. Publication Status: Online-Only"
> "Q9DBX2-1","RefSeq","NP_080452.2","23888055","Evidence of a generic mechanism, whereby the splicing of the PhLP gene could potentially and efficiently regulate the cellular levels of heterotrimeric G proteins."
> "Q9DBX2-1","RefSeq","NP_080452.2","23637185","This study demonstrated in vivo that PhLP1 is required for the folding and assembly of both Gbetagamma and Gbeta5-RGS9."
> "Q9DBX2-1","RefSeq","NP_080452.2","15889144","These results suggest a mechanism for Gbetagamma assembly in which PhLP stabilizes the nascent Gbeta polypeptide until Ggamma can associate, resulting in membrane binding of Gbetagamma and release of PhLP to catalyze another round of assembly."
> "Q9DBX2-1","RefSeq","NP_080452.2","12466282","Physiological control of G-protein regulation by PhLP seems to involve phosphorylation by CK2 and alternative splicing of the regulator"
> "Q9DBX2-1","RefSeq","NP_080452.2","12015208","N-glycosylated phosducin-like protein long (PhLP(L)) is expressed in all structures of the central nervous system and regulates opioid receptor function in the brain."
> "Q9DBX2-1","RefSeq","NP_080452.2","9139665","These data are consistent with the hypothesis that PhLP is a widely expressed modulator of Gbetagamma function."
19052,19054c25553,25554
< "O08759-1","RefSeq","NP_035798.2","30082419","In a mouse model of Angelman Syndrome, restoring UBE3A levels in adult animals fully rescued all the identified physiological deficits of mPFC neurons. Moreover, the kinetics of reversing these synaptic deficits closely followed the reinstatement of UBE3A protein level."
< "O08759-1","RefSeq","NP_035798.2","30020076","Here the authors report that Ube3a regulates mTORC1 signaling by targeting p18, a subunit of the Ragulator. Ube3a ubiquitinates p18, resulting in its proteasomal degradation. Publication Status: Online-Only"
< "O08759-1","RefSeq","NP_035798.2","12668607","Ube3a exhibits brain cell type-specific imprinting, with monoallelic expression from the maternal allele in neurons, but biallelic expression in glial cells. The antisense Ube3a transcript is reciprocally imprinted only in neurons."
---
> "P42232-1","RefSeq","NP_035619.3","30790510","Study enables us to conclude that beta-cell stress is aggravated by the incapability of STAT5B to induce Nos2 resulting in HO accumulation and the ensuing oxidative stress enhances beta-cell damage."
> "P42232-1","RefSeq","NP_035619.3","30114225","Study used a gene expression biomarker that can accurately predict the activation status of the oxidant-induced transcription factor Nrf2 in a microarray database and uncovered a strong linkage between increased Nrf2 activity and feminization of the male liver mediated by suppression of STAT5b. Examination of female versus male comparisons showed that Nrf2 is subtly but reproducibly activated to higher levels in females. Publication Status: Online-Only"
19068a25569,25581
> "Q810L3-1","RefSeq","NP_766305.2","26566864","CHFR is important for the survival of male premeiotic germ cells, which is likely through maintaining genomic stability in spermatogonial stem cells."
> "Q810L3-1","RefSeq","NP_766305.2","22337872","The interaction between CHFR and PARP-1 plays an important role in cell cycle regulation and cancer therapeutic strategies."
> "Q810L3-1","RefSeq","NP_766305.2","22285184","CHFR interacts with BRG1, SNF5, and BAF60a of the SWI/SNF-like BAF complex and ubiquitinates them to target for degradation through a proteasome-mediated pathway; SRG3 stabilizes these components by blocking their interaction with CHFR."
> "Q810L3-1","RefSeq","NP_766305.2","21706008","RNF8 and Chfr, function together to activate ATM and maintain genomic stability in vivo. Publication Status: Online-Only"
> "Q810L3-1","RefSeq","NP_766305.2","21245198","Stil protein regulates centrosome integrity and mitosis through suppression of Chfr."
> "Q810L3-1","RefSeq","NP_766305.2","19690386","Mice with deficiencies in both Chfr and Mlh1 (the gene that encodes the DNA mismatch-repair protein Mlh1) displayed dramatically higher incidence of spontaneous tumors relative to mice deficient for only one of these genes."
> "Q810L3-1","RefSeq","NP_766305.2","15793587","Downregulation of Chfr contributes to tumorigenesis by controlling the expression levels of Aurora A."
> "Q810L3-1","RefSeq","NP_766305.2","15467728","PML bodies control the distribution, dynamics and function of CHFR"
> "Q9ERZ3-1","RefSeq","NP_150372.1","29959237","Genetic M3R ablation in mouse cells results in improved remyelination and is mediated by acceleration of oligodendrocyte commitment from oligodendrocyte progenitor cells."
> "Q9ERZ3-1","RefSeq","NP_150372.1","30196290","The expression of M3-mAChR was down-regulated in the myocardium from aged mice and D-galactose-treated mice, while the expression levels of caspase-1 and its downstream molecule IL-1beta were significantly increased."
> "Q9ERZ3-1","RefSeq","NP_150372.1","28687610","Stimulation of the ERK pathway in Gnb5(-/-) cells by epidermal growth factor restored M3R-stimulated insulin release to near normal levels. Identification of the novel role of Gbeta5-R7 in insulin secretion may lead to a new therapeutic approach for improving pancreatic beta-cell function"
> "Q9DBA6-1","RefSeq","NP_082188.1","23459139","Our data established that peroxisomal processing protease Tysnd1 is necessary to mediate the physiological functions of PTS2-containing substrates."
> "Q9DBA6-1","RefSeq","NP_082188.1","22002062","Characterization of function of human TYSND1, including putative regulation by self-cleavage"
19106a25620,25625
> "Q9QUG3-1","RefSeq","NP_075530.1","24286250","Data suggest that glycosylation status of the prion protein and yet-to-be-identified proteases modulate internal C1 and C2 endoproteolysis of Doppel (doppelganger prion) and Shadoo (shadow of prion protein) in mouse neurons."
> "Q9QUG3-1","RefSeq","NP_075530.1","24339999","In GC-1 spg cells, phosphorylation of p21 and N-terminal truncated PrP may play roles in the control of Dpl-induced apoptosis, which may benefit the physiological function of Dpl in the male reproduction system. Publication Status: Online-Only"
> "Q9QUG3-1","RefSeq","NP_075530.1","24143866","Data on residue secondary structure propensities suggest that novel beta-sheets of doppel protein (Prnd) and prion protein (Prnp) are formed by amino acids belonging to helices that are the least stable in the respective native structures."
> "Q9QUG3-1","RefSeq","NP_075530.1","23345215","This finding identifies a protein domain that plays a role in mediating Dpl-related toxicity."
> "A2AMT1-1","RefSeq","NP_033881.2","29196765","AQP0 modulates GJs in the presence of BF proteins to maintain lens transparency and homeostasis."
> "A2AMT1-1","RefSeq","NP_033881.2","27559293","CP49 and filensin have been considered robust markers for mouse lens fiber cell differentiation. The data reported here, however, document both proteins in the mouse lens epithelium, but only after 5 weeks of age, when lens epithelial growth and mitotic activity have slowed. Publication Status: Online-Only"
19114a25634,25635
> "Q8K010-1","RefSeq","NP_694762.1","29118264","OPLAH depletion occurred as a result of cardiac injury, leading to elevated 5-oxoproline and oxidative stress, whereas OPLAH overexpression improved cardiac function after ischemic injury."
> "Q8K010-1","RefSeq","NP_694762.1","20413906","The cause of cellular ATP depletion in nephrotic cystinosis may be the futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase"
19130d25650
< "P07141-1","RefSeq","NP_001107002.1","30767584","In ovarian follicles, following the luteinizing hormone surge, levels of MCSF and MCSF receptor decrease"
19143a25664
> "Q52KG4-1","RefSeq","NP_001019870.1","21131782","Data suggest that Zbtb45 is a novel regulator of glial differentiation."
19146a25668,25674
> "Q05512-1","RefSeq","NP_031954.2","30654821","This studies show that loss of Par1b/MARK2 switches microglia from a surveillant to a primed state during development, resulting in an increased neuroinflammatory response to insults Publication Status: Online-Only"
> "Q05512-1","RefSeq","NP_031954.2","27788223","Data suggest ectopic PAR1 expression is not tolerated in mouse platelets and indicate a different approach is required to develop a small animal model for the purpose of any future preclinical testing of PAR antagonists as anti-platelet drugs Publication Status: Online-Only"
> "Q05512-1","RefSeq","NP_031954.2","27841695","These results indicate that the basal localization of Par-1b in the outer epithelial cells is required for myoepithelial cell compression, and Par-1b is required for myoepithelial differentiation, regardless of its localization."
> "Q64323-1","RefSeq","NP_035211.2","29115020","The reliability of using GPI anchor-deficiency as a valid reporter of Pig-a gene mutation."
> "Q64323-1","RefSeq","NP_035211.2","29098723","The assay may be useful for mutagenicity screening of environmental agents as well as for testing hypotheses in vitro before committing to in vivo Pig-a assays."
> "Q64323-1","RefSeq","NP_035211.2","29150045","Pig-a mutations were identified in all clones developed from CD90-deficient cells; no Pig-a mutations were found in clones of CD90-proficient cells. The spectrum of B[a]P-induced Pig-a mutations was dominated by basepair substitutions, small insertions and deletions at G:C, or at sequences rich in G:C content."
> "Q9EPQ1-1","RefSeq","NP_109607.1","29794015","The findings demonstrate that sensing of the microbiota by TLR1 may provide key signals that regulate the colonic epithelium, thereby limiting inflammation through the prevention of bacterial attachment to the mucosa and exposure to the underlying immune system."
19148a25677,25678
> "Q9DAN1-1","RefSeq","NP_082219.1","22357757","Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male infertility Erratum:[Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5905]"
> "Q9DAN1-1","RefSeq","NP_082219.1","15475357","The expression of PDILT, in addition to PDI in the testis, suggests that PDILT performs a specialized chaperone function in testicular cells. [PDILT]"
19180a25711,25713
> "O88520-1","RefSeq","NP_062632.2","27466182","Results provide evidence that SHOC2 trapping at different subcellular sites has a diverse impact on ERK signaling strength and dynamics, suggesting a dual counteracting modulatory role of SHOC2 in the control of ERK signaling exerted at different intracellular compartments."
> "O88520-1","RefSeq","NP_062632.2","20549726","Data suggest that SUR-8 may act in an ERK-independent pathway to regulate AVC development."
> "O88520-1","RefSeq","NP_062632.2","16301319","Erbin has a regulatory role in the Ras-Raf-MEK pathway and may inhibit ERK activation by disrupting the Sur-8-Ras/Raf interaction"
19184,19185d25716
< "P49919-1","RefSeq","NP_001155096.1","30284969","We propose that CDKN1c activity is restricted to differentiating myoblasts by regulated cyto-nuclear relocalization, coordinating the balance between proliferation and growth arrest. Publication Status: Online-Only"
< "P49919-1","RefSeq","NP_001155096.1","17517131","Cdkn1c, an imprinted gene with expression only from the maternal allele, is the major regulator of embryonic growth in the IC2 imprinted domain on mouse distal chromosome 7. Publication Status: Online-Only"
19191,19192d25721
< "Q9D9T6-1","RefSeq","NP_081576.2","27053129","Spermatogenesis-associated protein 3 (Spata3) and dickkopf-related protein 2 (Dkk2) were confirmed to interact with MIC3. The tandem repeat EGF domains of MIC3 were critical in mediating the interactions with the identified host proteins. The results show that MIC3 interacts with host proteins that are involved in reproduction, growth, and development."
< "Q9D9T6-1","RefSeq","NP_081576.2","18551385","Mtsarg1 and Mtsarg1-beta may play an important role in mouse testicular function and in spermatocyte development."
19193a25723,25726
> "Q8VI94-1","RefSeq","NP_660210.1","29463066","Results implicate that OASL1 plays context dependent functions in the antiviral response for the clearance and resolution of viral infections."
> "Q8VI94-1","RefSeq","NP_660210.1","27034232","These results show that OASL1 deficiency promotes the antitumor immune response, and thus, OASL1 could be a good therapeutic target for treating tumors."
> "Q8VI94-1","RefSeq","NP_660210.1","26750802","OASL1 deficiency promotes antiviral immunity against local mucosal viral infection. Publication Status: Online-Only"
> "Q8VI94-1","RefSeq","NP_660210.1","23874199","Data from knockout mice suggest that Oasl1 is involved in regulation of innate immunity; Oasl1 knockout mice mount a better virus-specific CD8-positive T-cell response to lymphocytic choriomeningitis virus."
19198a25732,25733
> "P50285-1","RefSeq","NP_034361.1","24792439","Data indicate that in contrast to FMO2 and FMO4, FMO1 is highly expressed in metabolic tissues, including liver, kidney, white adipose tissue (WAT) and brown adipose tissue (BAT)."
> "P50285-1","RefSeq","NP_034361.1","15183119","Fmo1, 2, 3, 4 and 5 exhibit distinct cell-, tissue-, sex- and developmental stage-specific patterns of expression."
19201a25737,25744
> "P09225-1","RefSeq","NP_034865.1","29936495","These data suggest that miR-21 can regulate astrocytic function, then promote the functional recovery after spinal cord injury via TNF-beta activation."
> "P09225-1","RefSeq","NP_034865.1","29593265","Lymphotoxin alpha has a role in regulating T cell clonal deletion by regulating thymic entry of antigen-presenting cells Publication Status: Online-Only"
> "P09225-1","RefSeq","NP_034865.1","28917655","TNF/Lymphotoxin alpha/beta deficiency influences PM2.5 exposure-induced response of energy metabolism through alterations in both food intake and energy expenditure."
> "Q8R331-1","RefSeq","NP_081594.1","30842416","Znhit1 promotes the interaction between H2A.Z and YL1 (H2A.Z chaperone) by controlling YL1 phosphorylation. These results demonstrate that Znhit1/H2A.Z is essential for Lgr5+ stem cell maintenance and intestinal homeostasis. Publication Status: Online-Only"
> "Q8R331-1","RefSeq","NP_081594.1","20473270","These results identify SRCAP/H2A.Z-mediated chromatin remodelling as a key early event in muscle differentiation-specific gene expression."
> "Q8R331-1","RefSeq","NP_081594.1","19501046","These findings identified Znhit1 as a CDK6 regulator that plays an important role in cell proliferation."
> "Q2MHN3-1","RefSeq","NP_001034287.1","23300874","Homozygous Zfhx2-deficient mice showed several behavioral abnormalities, namely, hyperactivity, enhanced depression-like behaviors, and an aberrantly altered anxiety-like phenotype"
> "Q2MHN3-1","RefSeq","NP_001034287.1","16257534","Results report features of zfh-5 isolated from the mouse brain; in addition to the mRNA, the antisense strand of zfh-5 is also expressed in the developing brain, in a manner complementary to the expression of zfh-5 mRNA."
19203c25746
< "Q9JHE7-1","RefSeq","NP_001108557.1","10915772","The orthologous gene pair, Tssc4/TSSC4, shows difference in imprinting between mouse and human. Mouse Tssc4 gene is imprinted, with preferential expression from the maternal allele in placenta, whereas, human TSSC4 gene is not imprinted."
---
> "Q8K1T6-1","RefSeq","NP_081642.1","26276394","Lynx2 and Ly6g6e have roles in intracellular trafficking and allosteric potentiation of alpha4beta2 nAChRs, respectively"
19219a25763,25765
> "O54910-1","RefSeq","NP_032716.2","30816488","REGgamma regulates NFkappaB activity by specifically degrading IkBepsilon to regulate inflammation in testicular Leydig cells."
> "O54910-1","RefSeq","NP_032716.2","27489104","The basic residues Lys-717 and Lys-719 in the C-terminal region of ANK7 contribute to IkappaBzeta binding to the Lcn2 promoter, probably via interaction with the cytosine-rich element required for Lcn2 activation; glutamate substitution for both lysines results in a loss of transcriptionally active complex formation without affecting direct contact of IkappaBzeta with p50."
> "O54910-1","RefSeq","NP_032716.2","12424381","Temporal control of NF-kappaB activation by the coordinated degradation and synthesis of IkappaB proteins"
19220a25767,25770
> "P27931-1","RefSeq","NP_034685.1","30343694","Our studies demonstrate that Zbtb38 forms a molecular bridge between an arthritis-associated epimutation (DNA hypomethylation in Zbtb38 promoter) and transcriptional silencing of the IL1r2 gene in B cells. In this way, disease-associated DNA hypomethylation can support autoimmune arthritis by interfering with an anti-inflammatory pathway."
> "P27931-1","RefSeq","NP_034685.1","30093408","Il1r2 encourages STAT3 to bind to cis-elements that regulate expression of interleukin-17."
> "P27931-1","RefSeq","NP_034685.1","29366788","Thus, we show that IL-1R2 is harmful for the development of colitis, because IL-1R2 promotes the growth of proinflammatory intestinal microbiota by suppressing IL-1beta-induced AMP production."
> "P27931-1","RefSeq","NP_034685.1","28235865","Our data demonstrate that the decoy receptor IL-1R2 plays an important inhibitory role in local IL-1- and neutrophil-dependent tissue inflammation"
19223a25774,25776
> "P35991-1","RefSeq","NP_038510.2","30635655","A novel role for BTK in regulating CD1d(hi)CD5(+) Breg differentiation."
> "P35991-1","RefSeq","NP_038510.2","30237801","This paper demonstrates distinct roles for Bruton's tyrosine kinase in B cell immune synapse formation Publication Status: Online-Only"
> "P35991-1","RefSeq","NP_038510.2","29516781","Blocking Btk specifically in the alveolar compartment led to significant attenuation of neutrophil extracellular traps released into the lung in vivo and neutrophil extracellular trap formation in vitro."
19224a25778,25779
> "Q5XJV6-1","RefSeq","NP_001277919.1","24760852","The dopamine metabolite levels and dopamine turnover rate are increased in the striata of Lmtk3(-/-) mice compared with controls. In addition, we found that LMTK3 is involved in the endocytic trafficking of N-methyl-d-aspartate receptors."
> "Q8BY35-1","RefSeq","NP_038738.2","17234881","The t allele of Fgd2 is overexpressed in testis compared with wild type, a loss-of-function allele of Fgd2 generated by gene targeting reduces the transmission ratio of the t haplotype t(h49), directly demonstrating the role of Fgd2 as Distorter."
19228a25784,25786
> "Q60613-1","RefSeq","NP_033760.2","30772395","A2a receptor increase cell viability, proliferation and insulin release through PKA/Akt/IPP-1/CREB signaling pathway"
> "Q60613-1","RefSeq","NP_033760.2","30627646","This study showed that synaptic A2AR critically control synaptic excitotoxicity, which underlies the development of convulsions-induced neurodegeneration. Publication Status: Online-Only"
> "Q60613-1","RefSeq","NP_033760.2","30400017","Protective role in obesity-associated adipose tissue inflammation"
19230a25789,25790
> "Q60597-1","RefSeq","NP_035086.2","28242228","Taken together, our results indicate that the redox sensing and ROS forming properties of Pdh and Ogdh are linked to S-glutathionylation"
> "Q60597-1","RefSeq","NP_035086.2","27582470","We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase and induces histone modifications in an ACL-dependent manner"
19235a25796,25808
> "Q9JLY7-1","RefSeq","NP_062793.2","29660332","DUSP14-knockdown in primary cardiomyocytes using its specific siRNA sequence elevated hypoxia and reoxygenation-induced activation of NF-kappaB and MAPKs signaling pathways, and reactive oxygen species generation."
> "Q9JLY7-1","RefSeq","NP_062793.2","29077210","Hepatocyte DUSP14 is required for maintaining hepatic metabolic homeostasis and for suppressing inflammation, a novel function that relies on constraining TAK1 hyperactivation"
> "Q9JLY7-1","RefSeq","NP_062793.2","26891723","Protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction possibly through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway"
> "Q9JLY7-1","RefSeq","NP_062793.2","17337450","Critical role for JNK1 in the regulation of Mkp1 induction and in LPS-dependent macrophage activation."
> "Q9JKC0-1","RefSeq","NP_062523.1","28759611","TPL-2-regulated Ccl24 in CD11c+CD11b+ cells prevents accelerated type-2 mediated immunity to H. polygyrus. Publication Status: Online-Only"
> "Q9JKC0-1","RefSeq","NP_062523.1","27484038","This study shows that TPL-2 inhibits Ccl24 expression in lung dendritic cells, and blockade of Ccl24 prevents the exaggerated airway eosinophilia and lung inflammation in mice given house dust mites-pulsed Map3k8-/- dendritic cells"
> "Q9JKC0-1","RefSeq","NP_062523.1","26376364","The increased airway eosinophils and mucous cell metaplasia in house dust mite-challenged Cd163-/- mice are mediated by augmented CCL24 production"
> "Q9JKC0-1","RefSeq","NP_062523.1","16102831","Distinct acidic and basic residues within CCR3 determine both receptor expression and activation by the eotaxins."
> "Q9JKC0-1","RefSeq","NP_062523.1","16210640","The eotaxin-2 pathway plays a fundamental role in eosinophil recruitment during ovalbumin-induced experimental asthma."
> "Q9JKC0-1","RefSeq","NP_062523.1","15647285","Results demonstrate a cooperative mechanism between interleukin-13 and eotaxin-2, where IL-13 mediates allergen-induced eotaxin-2 expression, and eotaxin-2 mediates IL-13-induced airway eosinophilia."
> "Q9JMF3-1","RefSeq","NP_071867.1","30157062","G protein gamma subunit, Ggamma13, is expressed in a spatiotemporal manner similar to those of Galphaolf and Galphai2 in the olfactory system and vomeronasal organ, respectively. In addition, Ggamma13 was found in the glomeruli of the main olfactory bulb but was largely absent in the glomeruli of the accessory olfactory bulb; and to play an essential role in odor-triggered social behaviors including male-male aggression."
> "Q9JMF3-1","RefSeq","NP_071867.1","25416620","Differential function of Ggamma13 in rod bipolar and ON cone bipolar cells"
> "Q9JMF3-1","RefSeq","NP_071867.1","12454992","Ggamma13 subunit is coexpressed in physiologically ON-type cone bipolar cells with Gbeta3 and Gbeta4 but is not present in OFF-type bipolar cells."
19237a25811,25814
> "Q3V089-1","RefSeq","NP_001028580.1","21364893","Although RBM44 localizes to intercellular bridges during meiosis, RBM44 is not required for fertility in contrast to TEX14. Publication Status: Online-Only"
> "Q60865-1","RefSeq","NP_058019.2","29157358","Thus, RNG105 has an essential role, as a key regulator of dendritic mRNA localization, in long-term memory formation. Publication Status: Online-Only"
> "Q60865-1","RefSeq","NP_058019.2","26865403","Behavioral analysis of RNG105 heterozygous mice showed reduced social interaction and attenuated response to novelty. Publication Status: Online-Only"
> "Q60865-1","RefSeq","NP_058019.2","14764709","Overexpression of a fusion protein of enhanced green fluorescent protein and caprin-1 induces dose-dependent suppression of the proliferation of NIH-3T3 cells, consistent with the notion that caprin-1 plays a role in cellular activation or proliferation."
19248,19249d25824
< "Q7TMB8-1","RefSeq","NP_001158133.1","30664619","Cyfip1 haploinsufficiency in mice led to decreased dendritic spine density and stability associated with social behavior and motor learning phenotypes. Behavioral training early in development resulted in alleviating the motor learning deficits caused by Cyfip1 haploinsufficiency. Publication Status: Online-Only"
< "Q7TMB8-1","RefSeq","NP_001158133.1","14508708","Indentification on mouse chromosome 7C"
19255,19260c25830,25831
< "Q3T9X0-1","RefSeq","NP_001095884.1","30105595","SLC2A9 regulates urate reabsorption in the mouse kidney."
< "Q3T9X0-1","RefSeq","NP_001095884.1","30336599","Its anti-hyperuricemic mechanisms may be ascribed to its inhibition of XOD and its up-regulation of organic anion transporter 1 (OAT1) and down-regulation of glucose transporter 9 (GLUT9). Publication Status: Online-Only"
< "Q3T9X0-1","RefSeq","NP_001095884.1","25100214","Intestinal uric acid transporter SLC2A9 has a role in early-onset metabolic syndrome in a mouse model Publication Status: Online-Only"
< "Q3T9X0-1","RefSeq","NP_001095884.1","17913964","Glucose uptake via GLUT9a and GLUT9b likely affects normal spermatogenesis, steroidogenesis, and sperm function in the mouse."
< "Q3T9X0-1","RefSeq","NP_001095884.1","16293642","MGLUT9 protein expression was significantly increased in the kidney and liver from streptozotocin-induced diabetic mice compared with nondiabetic animals"
< "Q3T9X0-1","RefSeq","NP_001095884.1","14657010","Blocking GLUT9 expression during preimplantation development had no effect on glucose transport or apoptosis but transfer of these embryos resulted in increased pregnancy loss, suggesting that GLUT9 is critical for early preimplantation development."
---
> "Q9EQR3-1","RefSeq","NP_115773.2","28274924","Dynamic coupling between TRPV4 and Ca(2+)-activated SK1/3 and IK1 K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 in kidney collecting duct cells."
> "Q9EQR3-1","RefSeq","NP_115773.2","12882916","SK1, -2, -3, and IK1 (SK4) are expressed in islet cells and insulin-secreting cells and are able to influence glucose-induced calcium responses, thereby regulating insulin secretion."
19287d25857
< "Q3V188-1","RefSeq","NP_001162164.1","24344237","EndoU is a critical regulator of an RNA-dependent pathway controlling peripheral B cell survival and antigen responsiveness that may contribute to peripheral B cell tolerance."
19294a25865
> "Q2KN98-1","RefSeq","NP_700455.3","26787558","SPECC1L as a novel modulator of PI3K-AKT signaling and AJ biology, required for neural tube closure and CNCC delamination. Publication Status: Online-Only"
19299a25871,25873
> "Q3TR08-1","RefSeq","NP_071869.2","29787756","The HO-1-mediated pathway is involved in the suppressive effects of FNDC4 on inflammation and insulin resistance."
> "Q3TR08-1","RefSeq","NP_071869.2","29977911","FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10 Publication Status: Online-Only"
> "Q3TR08-1","RefSeq","NP_071869.2","27066907","FNDC4 as a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases. Publication Status: Online-Only"
19301a25876,25877
> "D3Z3L3-1","RefSeq","NP_783608.3","26503954","This study identifies TRIM12c as a mouse TRIM5 equivalent, critical for host innate immunity."
> "D3Z3L3-1","RefSeq","NP_783608.3","19147168","Describe an expanded paralogous cluster of at least eight Trim5-like genes in mice"
19313a25890,25891
> "A2AUU0-1","RefSeq","NP_663499.2","29706498","METTL8 prohibits the activation of JNK signaling and enhances the differentiation of mouse ESCs. Collectively, our study uncovers a STAT3 target, Mettl8, which regulates mouse ESC differentiation via JNK signaling."
> "A2AUU0-1","RefSeq","NP_663499.2","18710950","TIP-6 was identified as a new member of the adipogenic cascade."
19315a25894,25903
> "Q9ERH6-1","RefSeq","NP_071718.1","30003515","These data suggest that MOAP-1 is required in the regulation of stress response in the dorsal raphe nucleus. Crosstalk between BDNF and 5-HT appears to play an important role in this stress response."
> "Q9ERH6-1","RefSeq","NP_071718.1","27320914","These findings reveal a role for MOAP-1 in Fas signaling in the liver by promoting MTCH2-mediated tBid recruitment to mitochondria."
> "Q9ERH6-1","RefSeq","NP_071718.1","16199525","MAP-1 is a direct mitochondrial target of Bax."
> "Q8K007-1","RefSeq","NP_758498.1","29062064","Loss of SULF1 expression is associated with corticospinal tract defect. Publication Status: Online-Only"
> "Q8K007-1","RefSeq","NP_758498.1","28490013","Shh signaling requires the coordinated activity of Sulf1 and Sulf2 in order to reach that threshold in the mouse ventral spinal cord"
> "Q8K007-1","RefSeq","NP_758498.1","27626699","Our findings show that Sulf-1 is an important tumor suppressor gene in hepatocellular carcinoma (HCC), and its over expression downregulates Msln and results in a decrease in HCC cell proliferation, migration, invasion, and lymphatic metastasis."
> "Q8K007-1","RefSeq","NP_758498.1","26764203","Sulf1 and Sulf2 play indispensable roles to maintain glomerular integrity and protective roles in diabetic nephropathy, probably by growth factor modulation."
> "Q8K007-1","RefSeq","NP_758498.1","12368295","Sulfs are extracellular endosulfatases with strong potential for modulating the interactions of heparan sulfate proteoglycans in the extracellular microenvironment"
> "P48615-1","RefSeq","NP_033545.1","30651543","Study utilizing mouse kidney cultures and time-lapse imaging provided quantitative experimental support that a ligand-receptor-based Turing mechanism, implemented via GDNF-RET signaling, specifies the areas of outgrowth during kidney branching morphogenesis. The positive feedback between GDNF and WNT11 enables the dense packing of the ureteric buds. Publication Status: Online-Only"
> "P48615-1","RefSeq","NP_033545.1","30516471","Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment. Publication Status: Online-Only"
19317,19319c25905,25910
< "Q8BK03-1","RefSeq","NP_001229336.1","28938432","The ovarian phenotypes of these mice suggested that the MIGA1/2 proteins play an important role in ovulation and ovarian steroidogenesis. In vivo and in vitro analyses of Miga1/2-knockout granulosa cells showed severe defects in luteinization and steroidogenesis and disordered mitochondrial morphology and function in response to gonadotropins."
< "Q8BK03-1","RefSeq","NP_001229336.1","26716412","Data indicate that mitoguardin (Miga) knoskout Miga1/2-/- females show greatly reduced quality of oocytes and early embryos and are subfertile."
< "Q8BK03-1","RefSeq","NP_001229336.1","26711011","Propose that MIGA1/2 proteins promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD."
---
> "O08688-1","RefSeq","NP_031628.1","29157313","MRNA in situ hybridization experiments were performed to identify the expression of CAPN5 in the mouse eye and brain Publication Status: Online-Only"
> "O08688-1","RefSeq","NP_031628.1","14981075","Calpain-derived Htt fragmentation has a role in Huntington's disease and aberrant activation of calpains may play a role in HD pathogenesis"
> "O08688-1","RefSeq","NP_031628.1","14749380","Despite the numerous expression sites of Capn5, the majority of Capn5-null mice were viable and fertile and appeared healthy"
> "Q9R078-1","RefSeq","NP_114075.1","29401588","The evidence indicates that AMPK is sufficient but not essential for the maintenance of DAPC expression in skeletal muscle, yet it is required for preserving extrasynaptic utrophin levels in slow oxidative muscles."
> "Q9R078-1","RefSeq","NP_114075.1","29316805","Activation of AMPK at early stage of adipogenesis is involved in the anti-adipogenesis effect of Red Pepper Seed extract."
> "Q9R078-1","RefSeq","NP_114075.1","28544264","In the absence of the tumor suppressor p53, germline genetic deletion of AMPK beta1 accelerates the appearance of a T-cell lymphoma that reduces lifespan compared to p53 deficiency alone."
19320a25912,25913
> "Q148B6-1","RefSeq","NP_083128.1","20542897","Speriolin is a novel centrosomal protein present in the connecting piece region of mouse sperm that is transmitted to the mouse zygote and can be detected throughout the first mitotic division."
> "Q148B6-1","RefSeq","NP_083128.1","15280373","Determined that speriolin is a spermatogenic cell-specific Cdc20-binding protein, present in cytoplasm, & concentrated at centrosomes of spermatocytes and spermatids; a leucine zipper domain is required to target speriolin to the centrosome [speriolin]"
19328a25922,25926
> "P51807-1","RefSeq","NP_033368.1","29094416","Show that MAP6 proteins interact directly with both Tctex1 and the C-terminus of Cav2.2/N-type calcium channels."
> "P51807-1","RefSeq","NP_033368.1","27502274","Activin receptor IIB as a novel DYNLT1 ligand and suggest that DYNLT1 functions as a molecular dimerization engine bringing together two receptor monomers in the cytoplasmic side of the membrane."
> "P51807-1","RefSeq","NP_033368.1","21262767","Targeted disruption of Tctex-1 by RNA interference significantly impairs bone resorption capacity and mislocalizes Rab3D vesicles in osteoclasts."
> "P51807-1","RefSeq","NP_033368.1","22028875","Dynlt1 modulates orexin signaling by regulating OX1R"
> "P51807-1","RefSeq","NP_033368.1","20575070","Results identify a regulatory region of the Tctex-1 gene that is capable of directing transgenic expression of green fluorescent protein (GFP) reporter that recapitulates the spatial and temporal expression pattern of endogenous Tctex-1."
19331a25930,25932
> "Q60855-1","RefSeq","NP_033094.3","30737145","Data show that IkappaB kinase (IKK) controlled thymocyte survival by repressing cell-death-inducing activity of the serine/threonine kinase RIPK1 (RIPK1)."
> "Q60855-1","RefSeq","NP_033094.3","30598363","Polo-like kinase 1 is recruited into mitotic ripoptosomes, where PLK1's activity is controlled via RIPK1-dependent recruitment and Caspase-8-mediated cleavage, ensuring chromosome stability and faithful chromosome segregation during mitosis."
> "Q91VM3-1","RefSeq","NP_758960.1","26000824","Nes-Wdr45(fl/Y) mice recapitulate some hallmarks of beta-propeller protein-associated neurodegeneration, including cognitive impairment and defective axonal homeostasis"
19334a25936,25939
> "Q9D9H3-1","RefSeq","NP_082833.1","18942147","Mbd3l1 and Mbd3l2 are not involved in genome-wide demethylation of paternal genomes in mouse zygotes and are dispensable for normal development."
> "Q9D9H3-1","RefSeq","NP_082833.1","15456747","Interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex"
> "Q8K2Q9-1","RefSeq","NP_780381.1","26849555","These results point to a role of CDKL5 in the early steps of neuronal differentiation that can be explained, at least in part, by its association with shootin1. Publication Status: Online-Only"
> "Q8K2Q9-1","RefSeq","NP_780381.1","23864681","Our data demonstrate the importance of the Shootin1/KIF20B interaction to the dynamic process of pyramidal neuronal polarization and migration."
19335a25941,25944
> "Q8CIN4-1","RefSeq","NP_796300.1","30791960","Study showed that conditional loss of Pak1 and Pak2 in mice resulted in an age-dependent myopathy with similarity to mice and humans with CHKbeta deficiency. Publication Status: Online-Only"
> "Q8CIN4-1","RefSeq","NP_796300.1","29297928","Pak2 is essential in maintaining the peripheral Treg cell pool by providing proliferation and maintenance signals to Foxp3(+) Treg cells."
> "Q8CIN4-1","RefSeq","NP_796300.1","28408623","PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases."
> "Q8CIN4-1","RefSeq","NP_796300.1","11782491","Phosphorylation of merlin at serine 518 is induced by the p21-activated kinase PAK2"
19338a25948,25954
> "Q5Y4Y6-1","RefSeq","NP_001007462.1","29695864","Cryo-electron microscopy structures of the 27-fold and 28-fold single-ring pores formed by the N-terminal fragment of mouse GSDMA3 (GSDMA3-NT) at 3.8 and 4.2 A resolutions, and of a double-ring pore at 4.6 A resolution"
> "Q5Y4Y6-1","RefSeq","NP_001007462.1","29372254","In this study, we describe a novel mutation (C+/H-: cornea plus, hair minus) in the far C-terminal region of Gasdermin A3 that causes both skin and corneal phenotypes."
> "Q5Y4Y6-1","RefSeq","NP_001007462.1","28168650","The function of Gsdma3 in regulating the development of mammary glands, and it demonstratse that the Gsdma3 gene may act as a suppressor of the immune reaction."
> "Q5Y4Y6-1","RefSeq","NP_001007462.1","27281216","Crystal structure of GSDMA3 showed an autoinhibited two-domain architecture that is conserved in the gasdermin family; the gasdermin-N domain is required for pyroptosis Erratum:[Nature. 2016 Dec 1;540(7631):150. PMID: 27706141]"
> "P08680-1","RefSeq","NP_033783.1","29958424","We used bioinformatics and computational biology tools to evaluate the role(s) of the C-terminal tail dynamics in the structure and conformational dynamics of the murine ALAS2 homodimer active site loop. Publication Status: Online-Only"
> "P08680-1","RefSeq","NP_033783.1","27928941","Data indicate that the 5-aminolevulinate synthase (mALAS2) active site loop harboring the simultaneous seven amino acid mutations was less flexible than the wild type loop."
> "P08680-1","RefSeq","NP_033783.1","26854603","We propose that the N-terminal truncation offers a cell-specific ALAS2 regulatory mechanism without hindering heme synthesis"
19383a26000,26001
> "A4Q9F1-1","RefSeq","NP_766406.2","23897886","The TTLL8 was required for stability and maintenance of ependymal cilia, whereas the polyglutamylase TTLL6 was necessary for coordinated beating behavior."
> "A4Q9F1-1","RefSeq","NP_766406.2","19427864","TTLL10 can strongly glycylate tubulin in a TTLL8-dependent manner. Furthermore, these two TTLL proteins can glycylate unidentified 170-, 110-, 75-, 40-, 35-, and 30-kDa acidic proteins."
19391,19395c26009,26014
< "Q9Z2G9-1","RefSeq","NP_001139521.1","25530119","Data suggest that TIP30 plays a negative regulatory role in oligodendroglial differentiation."
< "Q9Z2G9-1","RefSeq","NP_001139521.1","25175814","Overexpression or knockdown of Htatip2 in hepatocytes affected fatty acid storage and oxidation, consistent with a novel role in mediating the differential effects of PKC isoforms on lipid metabolism."
< "Q9Z2G9-1","RefSeq","NP_001139521.1","24853420","TIP30 is a key regulator for maintaining ER(+) and ER(-)luminal pools in the mammary luminal lineage, and loss of it promotes expansion of ER(+) luminal progenitors and mature cells and ER(+) mammary tumorigenesis. Publication Status: Online-Only"
< "Q9Z2G9-1","RefSeq","NP_001139521.1","22733137","TIP30 functions as a tumor suppressor to inhibit EGFR cytoplasmic and nuclear signaling and suppress adenocarcinogenesis in the lung."
< "Q9Z2G9-1","RefSeq","NP_001139521.1","21252234","TIP30 complex regulates EGFR endocytosis by facilitating the transport of V-ATPases from trans-Golgi network to early endosomes."
---
> "P22005-1","RefSeq","NP_001335138.1","30040980","Deficiency of preproenkephalin (PENK) or proopioimelanocortin (POMC) gene blocks analgesic effects following systemic administration of N-methyl-kyotorphin, NMYR and arginine in mice."
> "Q9JID9-1","RefSeq","NP_061295.2","24358267","Deletion of liver SH2B1 in SH2B2 null mice attenuated very low-density lipoprotein (VLDL) secretion. Publication Status: Online-Only"
> "Q9JID9-1","RefSeq","NP_061295.2","17620296","The association between SHIP2 and the adaptor protein Aps has an impact on biochemical properties of both partners."
> "Q9JID9-1","RefSeq","NP_061295.2","17204555","SH2B2beta is an endogenous inhibitor of SH2B1 and/or SH2B2alpha, negatively regulating insulin signaling and/or JAK2-mediated cellular responses."
> "Q9JID9-1","RefSeq","NP_061295.2","17102568","APS enhanced ligand-dependent multi-ubiquitination of the insulin receptor (IR) in CHO cells."
> "Q9JID9-1","RefSeq","NP_061295.2","11997497","APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes"
19399a26019,26021
> "Q8BW74-1","RefSeq","NP_766151.1","29262330","HLF-deficient hematopoietic stem cells display loss of quiescence and increased sensitivity to chemotoxic insults."
> "Q8BW74-1","RefSeq","NP_766151.1","26656780","Results demonstrate that Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations and that modulation of the pyridoxine pathway can also influence phenotype severity"
> "Q8BW74-1","RefSeq","NP_766151.1","15175240","Mice deficient for all three PAR bZip proteins (DBP,HLF,& TEF) are highly susceptible to generalized spontaneous and audiogenic epilepsies, frequently lethal. Pyridoxal kinase is a target gene of PAR bZip proteins in both liver and brain"
19403a26026,26032
> "Q9ES97-1","RefSeq","NP_444306.1","29716941","RTN3 has roles in inducing obesity and hypertriglyceridemia via interactions with heat shock protein family A (Hsp70) member 5, which then increases sterol regulatory element-binding protein 1c and AMP-activated kinase activity."
> "Q9ES97-1","RefSeq","NP_444306.1","28238655","RTN3 expression is a mediator of RBM3-induced neuroprotection, controlled by novel mechanisms of escape from translational inhibition on cooling."
> "Q9ES97-1","RefSeq","NP_444306.1","15946766","Since other reports have shown that RTN4-A inhibits neuronal outgrowth and restricts the plasticity of the central nervous system, we speculate that RTN3-A1 might play certain roles in the central nervous system."
> "Q9ES97-1","RefSeq","NP_444306.1","15350194","RTN3 isoforms may contribute, by as yet unknown mechanisms, to neuronal survival and plasticity"
> "Q9ES97-1","RefSeq","NP_444306.1","11990451","CDNA of mouse reticulon 3 (mRTN3) was cloned. The gene was mapped at band B of chromosome 19."
> "P48542-1","RefSeq","NP_034736.2","30902995","These results reveal selective small molecule binding and uncover a mechanism by which rotation of the cytoplasmic domain can modulate GIRK*phosphatidylinositide interactions. Publication Status: Online-Only"
> "P48542-1","RefSeq","NP_034736.2","29929098","The results of this study indicated that Kcnj6 triploid mice show an increase in GIRK2 protein levels compared to WT mice in the cortex and thalamus."
19409a26039,26041
> "Q80Y32-1","RefSeq","NP_821136.1","20511232","The first evidence of this novel HMG2L1 molecule playing an important role in attenuating smooth muscle differentiation"
> "P49452-1","RefSeq","NP_031709.2","28125646","Further investigation of the phosphoregulation of meiotic Kif4 revealed that Aurora Kinase and Cdk activity is critical for Kif4 kinetochore localization and interaction with Ndc80 and CENP-C. Finally, Kif4 protein but not gene expression was found to be upregulated with age, suggesting a role for this protein in the decline of oocyte quality with age Publication Status: Online-Only"
> "P49452-1","RefSeq","NP_031709.2","22540025","CENP-C works as an important factor for centromeric M18BP1 recruitment"
19421d26052
< "Q8VEL0-1","RefSeq","NP_001277443.1","21792907","Mospd1 plays a pivotal role in the developmental regulation at the switch between mesenchymal and epithelial cells."
19422a26054,26061
> "P10598-1","RefSeq","NP_034102.1","27836773","These results indicate that PRL, EGF and glucocorticoids have distinct roles in the establishment of beta-casein secretion pathway."
> "P10598-1","RefSeq","NP_034102.1","27130254","Dexamethasone signaling upregulates Claudin-3 and -4 without beta-casein expression. Prolactin and dexamethasone signaling synergistically upregulate beta-casein expression."
> "P10598-1","RefSeq","NP_034102.1","23313770","Octamer-binding transcription factor-1 may serve as a master regulator that facilitates the DNA binding of both signal transducer and activator of transcription 5 and glucocorticoid receptor in hormone-induced beta-casein expression"
> "P10598-1","RefSeq","NP_034102.1","22808460","It was found that both IGF-1 and IGF-2 activate the expression of milk protein beta-casein in the presence of prolactin and hydrocortisone. It was found that beta-casein expression is accompanied by cyclin D1 coexpression."
> "Q8BG87-1","RefSeq","NP_001334242.1","31043609","Study in mice lacking Tet2 and Tet3 in T-reg cells indicate that Tet2 and Tet3 are guardians of T-reg cell stability and immune homeostasis. Publication Status: Online-Only"
> "Q8BG87-1","RefSeq","NP_001334242.1","30979904","A non-catalytic action of TET3 is essentially required for the maintenance of the neural stem cell (NSC) pool in the adult subventricular zone niche by preventing premature differentiation of NSCs into non-neurogenic astrocytes Publication Status: Online-Only"
> "Q8BG87-1","RefSeq","NP_001334242.1","30575719","MiR-150 target that regulates monocyte subsets Publication Status: Online-Only"
> "Q8BG87-1","RefSeq","NP_001334242.1","20639862","All three mouse Tet proteins (Tet1, Tet2 and Tet3) can also catalyse conversion of 5-methylcytosine of DNA to 5-hydroxymethylcytosine"
19425,19427c26064,26066
< "Q8K019-1","RefSeq","NP_001020563.1","29466738","Myogenic differentiation is achieved through the specific interaction between Cry2 and Bclaf1, which stabilizes mRNAs encoding cyclin D1, a G1/S phase transition regulator, and Tmem176b, a transmembrane regulator for myogenic cell fusion."
< "Q8K019-1","RefSeq","NP_001020563.1","28120329","Constitutive expression of the anti-apoptotic molecule Bfl1 (A1) in murine vascular Endothelial Cells leads to prolonged allograft survival due to modifying inflammation."
< "Q8K019-1","RefSeq","NP_001020563.1","24453340","Bclaf1 facilitates the differentiation of early retinal precursors into retinal ganglion cells, amacrine cells, and horizontal cells rather than into cone photoreceptors."
---
> "Q8K479-1","RefSeq","NP_663588.2","26513502","Pathological effects of S163R mutation expression in retinal pigment epithelium"
> "Q8K479-1","RefSeq","NP_663588.2","17122142","CTRP5, a secretory and membrane-associated protein, is localized to the lateral and apical membranes of the RPE and CB. Impaired secretion of the mutant protein may underlie the pathophysiology of long anterior zonules and late-onset retinal degeneration."
> "Q8K479-1","RefSeq","NP_663588.2","16600989","L-ORMD is due to insufficient levels of secreted C1QTNF5, compromised RPE cell function resulting from ER retention of the mutant protein or both mechanisms."
19441a26081,26083
> "Q91XW8-1","RefSeq","NP_291049.1","22902560","Study identifies a requirement of mouse Fkbp6 for biogenesis of Miwi2 piRNAs GeneRIF: Transposon silencing Secondary piRNA biogenesis Cochaperone: interaction with Hsp90"
> "Q91XW8-1","RefSeq","NP_291049.1","18408354","Fundamental role of Fkbp6 in homologous chromosome synapsis during male meiosis"
> "Q91XW8-1","RefSeq","NP_291049.1","12764197","Fkbp6 is a component of the synaptonemal complex essential for sex-specific fertility and for the fidelity of homologous chromosome pairing in meiosis"
19444a26087,26088
> "P32261-1","RefSeq","NP_543120.1","30870413","Trancriptomic analysis shows that expression of the antithrombins serpin C1 and D1 is significantly reduced in Schwann cell-deficient mice. In the absence of peripheral neuromuscular activity, neurodegeneration is completely blocked, and expression of prothrombin in muscle is markedly reduced. Publication Status: Online-Only"
> "P32261-1","RefSeq","NP_543120.1","23550037","RNA interference of Serpinc1 and/or Proc allows for evaluation of the function of these genes in vivo and provides a novel, controlled mouse model for spontaneous venous thrombosis."
19447a26092,26095
> "Q69ZK9-1","RefSeq","NP_942562.2","30056576","This study provides a novel approach to understand the molecular basis of Fragile X syndrome by linking the dysregulated synaptic expression of NLGNs with FMRP"
> "Q69ZK9-1","RefSeq","NP_942562.2","30231918","NLGN2 participates in the regulation of sleep duration as well as electroencephalographic activity during wakefulness and sleep. Erratum:[Mol Brain. 2019 Jan 30;12(1):9. Cao, Feng [added]; Jia, Zhengping [added]. PMID: 30700334] Publication Status: Online-Only"
> "Q69ZK9-1","RefSeq","NP_942562.2","29859117","These results demonstrate a significant impact of a single point mutation NL2 R215H on brain functions. Publication Status: Online-Only"
> "Q69ZK9-1","RefSeq","NP_942562.2","15540461","The neuroligin 2 is as a new cell adhesion protein specific for inhibitory synapses and open new avenues for identifiying the constituents of this unique type of postsynaptic specialization."
19449a26098,26101
> "Q8JZL0-1","RefSeq","NP_065614.2","25490389","These results indicate that Zfp467 regulates the differentiation of adipose-derived stem cells via a mechanism involving Sost-mediated inhibition of Wnt signaling, suggesting potential therapeutic targets for the treatment of osteoporosis."
> "Q8JZL0-1","RefSeq","NP_065614.2","22252242","Zfp467 play an important role in adipose derived stem cells differentiation to adipocyte and osteoblast. Publication Status: Online-Only"
> "Q8JZL0-1","RefSeq","NP_065614.2","21123171","Zfp467 is a novel co-factor that promotes adipocyte differentiation and suppresses osteoblast differentiation"
> "Q8JZL0-1","RefSeq","NP_065614.2","12426389","EZI. EZI is a novel nuclear zinc finger protein that augments STAT3 activity by keeping it in the nucleus."
19459a26112,26118
> "Q9CX84-1","RefSeq","NP_080722.1","25766428","Our findings provide insight for the first time into the mechanisms involved in Rgs19 regulation of mouse ESC proliferation and differentiation."
> "Q9CX84-1","RefSeq","NP_080722.1","24775271","Notch signaling positively regulates phosphorylation of Akt, possibly via phosphorylation of RGS19"
> "Q9CX84-1","RefSeq","NP_080722.1","24751948","RGS19 and its partner Galpha-inhibiting activity polypeptide 3 (GNAI3) are involved in zVAD-, but not TNF-, induced cell death. Publication Status: Online-Only"
> "Q9CX84-1","RefSeq","NP_080722.1","12507475","Gene structure and transcription regulation"
> "O35912-1","RefSeq","NP_034259.2","29269102","Results suggest that Emp3 in allogeneic APCs possesses the inhibitory function of alloreactive CTL induction by downregulation of IL-2Ralpha expression CD8(+) T cells via an increase in TNF-alpha production."
> "Q9QXA1-1","RefSeq","NP_851293.1","29609111","These results suggest that Lmo3 promotes anxiety-like behavior specifically in the BLA, possibly by altering Crhr1 expression."
> "Q9DAK4-1","RefSeq","NP_083586.1","18786628","FABP12 arose as the result of tandem gene duplication, a mechanism that may have been instrumental to the expansion of the FABP family."
19466,19469c26125,26128
< "P70704-1","RefSeq","NP_001034088.1","27287255","In a sociability test, the Atp8a1+ mice displayed no preference for an encaged stranger mouse over a novel object, which is a characteristic autistic-like behavior. In sharp contrast, Atp8a1 (-/-) mice displayed a preference for a stranger mouse over the novel object, which is characteristic of neurotypical mouse behavior."
< "P70704-1","RefSeq","NP_001034088.1","22007859","The data of this study strongly indicated that Atp8a1 plays a central role in the PM-APLT activity of some mammalian cells."
< "P70704-1","RefSeq","NP_001034088.1","17239457","Such observations suggest tissue-specific differences in transcription initiation complex assembly and regulation of ATPase II gene expression."
< "P70704-1","RefSeq","NP_001034088.1","14975727","Role in normal phospholipid distribution in the bilayer, and for normal binding, penetration, and signaling by the zona pellucida"
---
> "Q9EQ80-1","RefSeq","NP_075364.2","12522100","Nif3l1 participates in neural differentiation of P19 cells through cooperation with Trip15/CSN2."
> "Q9D1G3-1","RefSeq","NP_083371.2","25841338","MG56 seems essential for postnatal skeletal muscle maturation"
> "Q9D1G3-1","RefSeq","NP_083371.2","18081866","Results suggest that Gup1 is a negative regulator of N-terminal palmitoylation of Shh and may contribute to the variety of biological actions of Shh"
> "Q9D8S3-1","RefSeq","NP_079721.2","24719103","ArfGAP3 interacts with RIBEYE in an NAD(H)-dependent manner."
19488a26148,26150
> "Q925E8-1","RefSeq","NP_598436.1","15777716","ADMP (androgen down regulated gene expressed in mouse prostate) expression appears to be androgen-dependent in the kidney and brain of normal intact mouse suggesting tissue specific regulation by androgens."
> "Q8BKE9-1","RefSeq","NP_080595.2","17971504","Ift74 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
> "Q8BKE9-1","RefSeq","NP_080595.2","16705683","Results identify a cDNA encoding the mouse ortholog of capillary morphogenesis gene (CMG)-1, and suggest that CMG-1 may play a role in the transcriptional regulation of the cyclin D2 gene."
19512a26175,26179
> "P62835-1","RefSeq","NP_663516.1","30767320","Current results suggest an important role of basal Rap1 activation status of HSPC in their maintenance in BM for sustaining long-term adult hematopoiesis."
> "P62835-1","RefSeq","NP_663516.1","30442677","Findings suggest that direct Rap1/Talin1 interaction is of particular importance in regulating the activity of different integrin classes expressed on platelets and neutrophils, which both depend on fast and dynamic integrin-mediated responses."
> "P62835-1","RefSeq","NP_663516.1","30307978","Data found that Rap1-/- female mice were more susceptible to DEN-induced hepatocellular carcinoma (HCC) than wild-type controls as indicated by earlier onset and increased number of both pre-neoplastic lesions and HCC, which was accompanied by a significantly decreased lifespan as the consequence of liver cancer. Publication Status: Online-Only"
> "P62835-1","RefSeq","NP_663516.1","30257685","Modulation of Rap1 by Pde6delta accommodates key mechanisms underlying neuronal activity Publication Status: Online-Only"
> "P62835-1","RefSeq","NP_663516.1","30242097","The Rap1-talin 1 F0 interaction has little effect on platelet GPIIb-IIIa activation and hemostasis and cannot account for the dramatic effects of loss of Rap1 activity on these platelet functions."
19513a26181,26183
> "Q91V17-1","RefSeq","NP_573469.1","28593998","This study defines ZNRF1 as a regulator of TLR4-induced inflammatory responses and reveals another mechanism for the regulation of TLR4 signalling through CAV1. Publication Status: Online-Only"
> "Q91V17-1","RefSeq","NP_573469.1","26572622","Up-regulation of ZNRF1 activity by oxidative stress leads to neuronal apoptosis and Wallerian degeneration."
> "Q91V17-1","RefSeq","NP_573469.1","22057101","The ZNRF1-AKT-GSK3B-CRMP2 pathway plays an important role in controlling Wallerian degeneration. Publication Status: Online-Only"
19523a26194,26198
> "O35350-1","RefSeq","NP_031626.1","30327977","The involvement of calpain in survival motor neuron 1 regulation on motor neurons, was examined."
> "O35350-1","RefSeq","NP_031626.1","30874894","Increased mitochondrial calpain-1 is an important mechanism contributing to myocardial injury and heart failure by disrupting ATP synthase, and promoting mitochondrial superoxide generation and mitochondrial permeability transition pore opening. Publication Status: Online-Only"
> "O35350-1","RefSeq","NP_031626.1","30617807","In this chapter we describe a method to knockdown calpain 1 in mouse pulmonary vascular endothelium using delivery of siRNA/cationic liposome complex"
> "O35350-1","RefSeq","NP_031626.1","30409431","Calpain-1 null neutrophils failed to migrate through TNF-activated endothelial monolayers. Erratum:[Biochem Biophys Res Commun. 2019 Jan 22;508(4):1292. PMID: 30573359]"
> "O35350-1","RefSeq","NP_031626.1","30177812","Isoform-specific hyperactivation of calpain-2, but not calpain-1 occurs at the synapse early in the pathogenesis of Alzheimer's disease potentially contributing to the deregulation of synaptic signaling in humans and mice models. Publication Status: Online-Only"
19525a26201,26205
> "Q99JY0-1","RefSeq","NP_663533.1","25816318","Nonstructural protein 5 (NS5) interacted with hydroxyacyl-CoA dehydrogenase alpha and beta subunits, two components of the mitochondrial trifunctional protein (MTP) involved in LCFA beta-oxidation Publication Status: Online-Only"
> "Q501J6-1","RefSeq","NP_951062.1","29431742","Mechanistic studies reveal that MeXis interacts with and guides promoter binding of the transcriptional coactivator DDX17. The identification of MeXis as a lncRNA modulator of LXR-dependent gene expression expands understanding of the mechanisms underlying cell type-selective actions of nuclear receptors in physiology and disease."
> "Q501J6-1","RefSeq","NP_951062.1","26947125","Data show that p72/DDX17 specifically interacts with the miR-132 loop sequence and influences the relative ratio of the mature mice miR-212/132 miRNAs. Publication Status: Online-Only"
> "Q501J6-1","RefSeq","NP_951062.1","22266867","Data indicate that transcriptional coregulator ddx5/ddx17 RNA helicases can simultaneously regulate the transcriptional activity and alternative splicing of NFAT5 transcription factor."
> "O88898-1","RefSeq","NP_035771.1","30866939","GSK-3beta was essential for sustaining fetal oocyte survival and folliculogenesis via fine-tuning the cytoplasmic-nuclear translocation of beta-catenin, which in turn modulates timely TAp63 expression during meiotic prophase I in mice. Publication Status: Online-Only"
19535d26214
< "Q3URQ7-1","RefSeq","NP_001159954.1","26525917","Identifies DDX58 and MTHFSD as two TDP-43 targets that are misregulated in amyotrophic lateral sclerosis. 1"
19544a26224,26228
> "Q8K087-1","RefSeq","NP_666362.1","29793502","Gpr1 deficiency leads to the improvement of steroid synthesis in mice hyperandrogenized with DHEA, indicating that GPR1 may be a therapeutic target for DHEA-induced hyperandrogenism. Publication Status: Online-Only"
> "Q8K087-1","RefSeq","NP_666362.1","24895415","This study provides further support the hypothesis that a functional chemerin system is required for the maintenance of healthy glucose homeostasis during obesity in mice lacking the active chemerin receptor GPR1."
> "Q8K087-1","RefSeq","NP_666362.1","24589776","A maternal germline differentially methylated region (DMR) at the mouse Gpr1/Zdbf2 (DBF-type zinc finger-containing protein 2) locus, which controls the paternal-specific expression of long isoforms of Zdbf2 (Liz) in the early embryo"
> "Q8K087-1","RefSeq","NP_666362.1","22449967","Results identified a novel, paternally expressed, long intergenic non-coding Zdbf2 variant (Zdbf2linc) transcribed from maternally methylated Gpr1 during early embryogenesis in the mouse."
> "Q8K087-1","RefSeq","NP_666362.1","20385583","Identification of differentially methylated regions within the Gpr1-Zdbf2 imprinted domain."
19562,19563c26246,26247
< "P42682-1","RefSeq","NP_001116226.1","26466958","Taken together, these data indicate that ITK plus RLK inhibition may have therapeutic potential in Th1-mediated inflammatory diseases."
< "P42682-1","RefSeq","NP_001116226.1","22403441","TXK plays an overlapping role with ITK in iNKT cell development and function. ITK also has a unique function in the survival of iNKT cells, likely via a p53-dependent pathway."
---
> "Q9JKY7-1","RefSeq","NP_062797.3","30944282","Its mRNA expression is decreased by the high level of MRSA, but the low level of MRSA increased its expression."
> "Q9JKY7-1","RefSeq","NP_062797.3","19594327","CYP2D22 is expressed in mouse striatum and has a possible role in the MPTP-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection"
19566,19569c26250,26257
< "Q62219-1","RefSeq","NP_001276479.1","29242607","High HIC5 expression is associated with tumorigenesis of colorectal cancer."
< "Q62219-1","RefSeq","NP_001276479.1","27893716","Isolated Hic-5(-/-);PyMT CAFs were defective in stress fiber organization and exhibited reduced contractility. These cells also failed to efficiently deposit and organize the ECM in two and three dimensions. This, in turn, impacted three-dimensional MDA-MB-231 tumor cell migration behavior"
< "Q62219-1","RefSeq","NP_001276479.1","28139974","Together, the authors show the antagonistic regulation of the alpha-enhancer activity by Pax6 and the LIM protein complex is necessary for the establishment of an inner retinal circuitry, which controls visual adaptation. Publication Status: Online-Only"
< "Q62219-1","RefSeq","NP_001276479.1","27269065","Paxillin and Hic-5 have both redundant and distinctive functions in invadosome formation."
---
> "Q2TB02-1","RefSeq","NP_742154.1","30127089","These results indicated that allelic variants of Nfkbid contribute to the efficiency of intrathymic deletion of diabetogenic CD8+ T cells"
> "Q2TB02-1","RefSeq","NP_742154.1","27878831","IkappaBNS is involved in inducing Muc5ac expression in lung epithelial cells and causing AHR in HDM-induced asthma models."
> "Q2TB02-1","RefSeq","NP_742154.1","17641034","IkappaBNS regulates production of interleukin (IL)-2 and other cytokines induced via T-cell receptor ligation."
> "Q2TB02-1","RefSeq","NP_742154.1","16413922","IkappaBNS regulates inflammatory responses by inhibiting the induction of a subset of TLR-dependent genes through modulation of NF-kappaB activity."
> "Q2TB02-1","RefSeq","NP_742154.1","11931770","Blocks transcription from NF-kappa B reporters, alters NF-kappa B electrophoretic mobility shifts, and interacts with NF-kappa B proteins in thymic nuclear lysates following TCR stimulation."
> "Q80ZD8-1","RefSeq","NP_666249.2","26240432","The AMIGO1-KCNB1 complex is involved in schizophrenia-related behavioral domains in mice."
> "Q80ZD8-1","RefSeq","NP_666249.2","22056818","AMIGO is a function-modulating auxiliary subunit for Kv2.1. Publication Status: Online-Only"
> "P35583-1","RefSeq","NP_034576.2","30923168","Studies show that the lncRNA Falcor fine-tunes the expression of Foxa2 and that disruption of the Falcor-Foxa2 transcriptional circuit results in subtle defects in lung airway epithelial homeostasis and more dramatic defects in airway regeneration after acute injury"
19574,19578c26262,26277
< "O70293-1","RefSeq","NP_001106182.1","30576947","Findings show that chemerin-activated CMKLR1 regulation in inflammatory macrophages is largely GRK6 and beta-arrestin mediated, which may impact innate immunity and have therapeutic implications in rheumatic disease."
< "O70293-1","RefSeq","NP_001106182.1","29969579","These data indicate that GRK2, GRK5 and GRK6 redundantly modulate Smo-GATA crosstalk in fetal mouse hearts, orchestrating transcriptional pathways previously linked to clinical and experimental atrioventricular canal defects"
< "O70293-1","RefSeq","NP_001106182.1","28939643","These studies suggest a previously unrecognized and novel role for GRK6 in neutrophil migration specific to pulmonary tissue during bacterial infection."
< "O70293-1","RefSeq","NP_001106182.1","28457871","Conditions for optimal dendritic cells guidance are perfectly provided by the CCL21 gradients measured in vivo. Furthermore, CCR7 signal termination by the G-protein-coupled receptor kinase 6 (GRK6) is crucial for haptotactic but dispensable for chemotactic CCL21 gradient sensing in vitro and confirm those observations in vivo."
< "O70293-1","RefSeq","NP_001106182.1","12032308","Deficiency causes defective lymphocyte chemotaxis"
---
> "P60330-1","RefSeq","NP_001014976.1","30305303","Thus, tethering of separase to DSBs and confined cohesin cleavage promote DSB repair in G2 cells. Importantly, this conserved interphase function of separase protects mammalian cells from oncogenic transformation."
> "P60330-1","RefSeq","NP_001014976.1","26858254","Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway."
> "P60330-1","RefSeq","NP_001014976.1","24276237","Separase-overexpressing mammary cells are not only susceptible to chromosomal missegregation-induced aneuploidy but also other genetic instabilities"
> "Q9QXS6-1","RefSeq","NP_062787.2","30625038","Neuronal drebrin A directly interacts with mDia2 formin."
> "Q9QXS6-1","RefSeq","NP_062787.2","30317558","Versus micropinocytosis activities. Taken together, these findings now reveal that Dbn1 plays a major role in coordinating the actin cytoskeletal activities responsible for antigen presentation in DC."
> "Q9QXS6-1","RefSeq","NP_062787.2","30700723","An excess of reactive oxygen species stimulates ATM-dependent phosphorylation of DBN at serine-647, which enhances protein stability and accounts for improved stress resilience in dendritic spines. Publication Status: Online-Only"
> "Q9QXS6-1","RefSeq","NP_062787.2","12761245","Drebrin is involved in regulation of actin dynamics also outside the nervous system. Drebrin is one of the actin-binding proteins regulating the actomyosin system and the dynamics of mesangial cells and foot processes in podocytes."
> "Q9CV60-1","RefSeq","NP_001291668.1","29364044","Results demonstrate that the FGF2-mediated repression of Linc-RAM expression occurs through MyoD via the Ras/Raf/Mek/Erk signaling pathway during myogenic differentiation. Present data provide convincing evidence that Linc-RAM is a lineage-specific lncRNA that plays regulatory roles in modulating muscle cell differentiation via FGF2-mediated signaling."
> "Q9CV60-1","RefSeq","NP_001291668.1","28091529","Linc-RAM regulates expression of myogenic genes by directly binding MyoD, which in turn promotes the assembly of the MyoD-Baf60c-Brg1 complex on the regulatory elements of target genes. Publication Status: Online-Only"
> "Q9CV60-1","RefSeq","NP_001291668.1","25640239","The human and mouse MLN genes consist of three exons that span 16.5 and 15.0 kb, respectively, with the ORF located in exon 3; findings identify MLN as an important regulator of skeletal muscle physiology."
> "Q8CBR6-1","RefSeq","NP_001162013.1","23206892","The combinatorial guidance activities of draxin and Tsukushi are essential for forebrain commissure formation"
> "Q8CBR6-1","RefSeq","NP_001162013.1","22995554","TSK controls the hair cycle by regulating TGF-beta1 signaling."
> "Q8CBR6-1","RefSeq","NP_001162013.1","21856951","Targeted inactivation of the TSK gene in mice causes expansion of the ciliary body and up-regulation of Wnt2b and Fzd4 expression in the developing peripheral eye"
> "Q8CBR6-1","RefSeq","NP_001162013.1","21055390","A crucial role for TSK for anterior commissure formation in the mouse brain was shown."
> "O70139-1","RefSeq","NP_035236.1","16870489","These results indicate that the downregulation of PKIgamma may be prerequisite for the PKA activation during the osteoblastic differentiation of precursor cells."
> "O70139-1","RefSeq","NP_035236.1","15557275","Endogenous levels of PKI regulate PKA signaling"
19584a26284,26286
> "O89116-1","RefSeq","NP_058558.1","24902738","In adrenal chromaffin cells, vti1a localizes to a compartment near the trans-Golgi-network, but is absent from secretory granules.Vti1a is not required for final fusion of dense-core vesicles, but is needed for their generation."
> "O89116-1","RefSeq","NP_058558.1","22646850","VTI1A, a vesicular transport associated factor is a novel regulator of hepatitis C virus release but not replication."
> "O89116-1","RefSeq","NP_058558.1","21262811","Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development"
19592a26295,26310
> "Q3UR85-1","RefSeq","NP_001028653.1","30249802","TMEM98 membrane protein physically interacts with MYRF in the endoplasmic reticulum and subsequently blocks its self-cleavage."
> "Q3UR85-1","RefSeq","NP_001028653.1","30166609","This study identifies the N-terminal-most domain as the transactivation domain of Myrf. Publication Status: Online-Only"
> "Q3UR85-1","RefSeq","NP_001028653.1","22956843","Expression of MRF within the adult central nervous system (CNS) is critical to maintain oligodendrocyte identity and integrity of CNS myelin."
> "Q3UR85-1","RefSeq","NP_001028653.1","21938520","NPC1 protein was expressed in oligodendrocytes and the amount of myelin protein was generally decreased in all parts of the brain and spinal cord in NPC1-mutant mice"
> "Q3UR85-1","RefSeq","NP_001028653.1","19596243","Study identifies gene model 98, which we have named myelin gene regulatory factor (MRF), as a transcriptional regulator required for CNS myelination."
> "Q58FA4-1","RefSeq","NP_001013386.2","29429824","Loss of E2F8 expression is associated with tumorigenesis in liver. Erratum:[Dev Cell. 2018 Nov 5;47(3):390. PMID: 30399338]"
> "Q58FA4-1","RefSeq","NP_001013386.2","29329320","We identified atypical E2fs to be essential for polyploidization in the pancreas and discovered that postnatal induced loss of both atypical E2fs in many organs is compatible with life until old age Publication Status: Online-Only"
> "Q58FA4-1","RefSeq","NP_001013386.2","27454291","E2F8-mediated transcriptional repression is a critical tumor suppressor mechanism during postnatal liver development"
> "Q58FA4-1","RefSeq","NP_001013386.2","16179649","E2F8 may have an important role in repressing the expression of E2F-target genes in the S-phase of the cell cycle. Publication Status: Online-Only"
> "Q58FA4-1","RefSeq","NP_001013386.2","15722552","Overexpression of E2F8 significantly slows down the proliferation of primary mouse embryonic fibroblasts."
> "O70342-1","RefSeq","NP_057917.2","28485050","Study suggests that PYY3-36 mediated signalling via Y5 receptors may counteract the anorectic effects that it mediates via the Y2 receptor, consequently lowering bodyweight in the absence of Y5 signalling."
> "O70342-1","RefSeq","NP_057917.2","28057538","NPY and agonists of Y2R and Y5R may be neuroprotective against oxygen-glucose deprivation-induced neuronal cell death in primary cortical cell cultures after delayed treatment. A Y2R agonist not only diminished transient cerebral ischemia-induced neuronal injury, but also improved functional outcome after delayed treatment. Y5 and especially Y2 receptors may be promising targets for neuroprotection against ischemic damage"
> "O70342-1","RefSeq","NP_057917.2","27984021","Y5-immunoreactivity was distributed widely in mouse brain, and the Y5 protein localization was mostly observed in the somata of the Y5 neurons. By purifying the polyclonal antibody with fixed knockout mouse tissue, the precise Y5 localization became obvious in mouse brain, especially in areas other than the hypothalamic area."
> "O70342-1","RefSeq","NP_057917.2","24985894","Study shows pronounced adaptive changes in the mouse hippocampus both with regard to NPY synthesis and NPY receptor synthesis and binding, which may contribute to regulating neuronal seizure susceptibility after kainate"
> "P40645-1","RefSeq","NP_035575.1","30667104","Through alternative splicing, LncRNA C130071C03Riken variants Riken-201 (Riken-201) and Riken-203 (Riken-203) identify the functional role of Rik-201 and Rik-203 in facilitating neural differentiation and further brain development, and elucidate the underlying miRNAs-Sox6-associated molecular mechanisms"
> "P40645-1","RefSeq","NP_035575.1","17433257","Thus, we successfully identified the Sox6 promoter and its core enhancer and characterized the interactions with regulatory transcription factors."
19598a26317
> "Q9D4G2-1","RefSeq","NP_083178.1","23707421","HSF2BP may play a pivotal role in regulating BNC1 transcriptional activity and subcellular localization during spermatogenesis."
19611a26331,26333
> "P62482-1","RefSeq","NP_034728.2","24211303","Article reports a newly identified protein-protein interaction between the postsynaptic density-protein ProSAP2/Shank3 and the voltage-gated potassium channel subunit Kvbeta2"
> "P62482-1","RefSeq","NP_034728.2","24036102","The association of a Kvbeta subunit with TRPV1 channels, is reported."
> "P62482-1","RefSeq","NP_034728.2","21209188","This study demonistrated that loss of Kvbeta2 likely contributes to the cognitive and neurological impairments observed in 1p36DS patients."
19627a26350,26354
> "Q3LR78-1","RefSeq","NP_780746.2","30343694","Our studies demonstrate that Zbtb38 forms a molecular bridge between an arthritis-associated epimutation (DNA hypomethylation in Zbtb38 promoter) and transcriptional silencing of the IL1r2 gene in B cells. In this way, disease-associated DNA hypomethylation can support autoimmune arthritis by interfering with an anti-inflammatory pathway."
> "Q3LR78-1","RefSeq","NP_780746.2","22315219","CIBZ post-transcriptionally regulates the expression of Nanog."
> "Q3LR78-1","RefSeq","NP_780746.2","22427977","CIBZ, a novel BTB domain-containing protein, is involved in mouse spinal cord injury via mitochondrial pathway independent of p53 gene."
> "Q3LR78-1","RefSeq","NP_780746.2","21625269","CIBZ binds to a Myog promoter-proximal region and inhibits Myog transcription in a methylation-dependent manner."
> "Q3LR78-1","RefSeq","NP_780746.2","18375381","CIBZ plays an important role by participating in the negative regulation of apoptosis in murine cells"
19634,19639c26361,26363
< "Q9ESU6-1","RefSeq","NP_065254.3","31292434","Time-series modeling of cerebellar granule cell progenitors (GCP) cell cycle exit identified downregulation of activity of the epigenetic reader protein Brd4. Brd4 binding to the Gli1 locus is controlled by casein kinase 1delta-dependent phosphorylation during GCP proliferation and decreases during GCP cell cycle exit. Publication Status: Online-Only"
< "Q9ESU6-1","RefSeq","NP_065254.3","30745801","MiR-29a negatively regulates hepatic stellate cell activation by inhibiting BRD4 and EZH2 function. Publication Status: Online-Only"
< "Q9ESU6-1","RefSeq","NP_065254.3","29662175","Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity in mouse embryonic stem cells."
< "Q9ESU6-1","RefSeq","NP_065254.3","29694891","RelA-BRD4 signaling in distal tracheobronchiolar epithelial cells mediates acute inflammation in response to luminal viral patterns."
< "Q9ESU6-1","RefSeq","NP_065254.3","12192049","Brd4 binds to replication factor C and inhibits progression to S phase"
< "Q9ESU6-1","RefSeq","NP_065254.3","11997514","Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4."
---
> "Q5DTT4-1","RefSeq","NP_001265463.1","28919299","The results introduce Rgag4 to the repertoire of effectors serving to couple the chromatin remodeler Ikaros with the hormonal stress response."
> "Q9QZR0-1","RefSeq","NP_067288.2","18757723","Identify an EGFR-independent action of TGF-alpha, in which it protects Naked2 from proteasomal degradation, thus ensuring its delivery to the basolateral surface of polarized epithelial cells"
> "Q9QZR0-1","RefSeq","NP_067288.2","12748188","RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit."
19646a26371
> "Q9EQC0-1","RefSeq","NP_076339.1","29659839","CHST1 does not contribute to the synthesis of glycan ligands for Siglec-F in the airways, although its absence results in exaggerated accumulation of airway macrophages and lymphocytes."
19651a26377,26382
> "Q9DBY1-1","RefSeq","NP_083045.4","30543180","N the absence of both RNF145 and gp78, Hrd1, a third UBE2G2-dependent E3 ligase, partially regulates HMGCR activity. Our findings reveal a critical role for the sterol-responsive RNF145 in HMGCR regulation and elucidate the complexity of sterol-accelerated HMGCR degradation Publication Status: Online-Only"
> "Q9DBY1-1","RefSeq","NP_083045.4","30389664","HRD1-ERAD catalyzes polyubiquitin conjugation onto CREBH at lysine 294 for its proteasomal degradation, bridging a multi-organ crosstalk in regulating growth, circadian behavior, and female fertility through regulating the CREBH-FGF21 regulatory axis."
> "Q9DBY1-1","RefSeq","NP_083045.4","30201971","HRD1 is a liver metabolic regulator and a potential drug target for obesity, fatty liver disease, and insulin resistance associated with the metabolic syndrome Publication Status: Online-Only"
> "Q9DBY1-1","RefSeq","NP_083045.4","29916549","The KAT4 promoter was significantly activated by the transcriptional factors, NFE2related factor 2 and peroxisome proliferatoractivated receptor coactivator 1beta, which are targets of Syvn1induced degradation"
> "Q9DBY1-1","RefSeq","NP_083045.4","16055742","Transcriptional regulation of synoviolin via EBS-1 (ETS binding site) plays an important role in cellular homeostasis"
> "Q9DBY1-1","RefSeq","NP_083045.4","15611074","Synoviolin has an indispensable role in embryogenesis"
19659a26391,26399
> "O70309-1","RefSeq","NP_034710.2","29676784","Mice lacking alphavbeta5 on haematopoietic cells show increased susceptibility to chemical colitis and we conclude that alphavbeta5 contributes to the tissue repair by regulating the homeostatic properties of intestinal macrophages"
> "O70309-1","RefSeq","NP_034710.2","28077433","Osteoprotegerin facilitates pulmonary arterial hypertension pathogenesis by regulating pulmonary arterial smooth muscle cell proliferation via integrin alphavbeta3/FAK/AKT signaling pathway."
> "O70309-1","RefSeq","NP_034710.2","27493116","Suggest that alphavbeta3 integrin plays an important role in coordinating hepatocyte division during liver regeneration after partial hepatectomy via crosstalk with fibrin ECM."
> "O08915-1","RefSeq","NP_057875.1","27706259","Results demonstrated that Aip inactivation promoted somatotroph tumorigenesis and overproduction of growth hormone probably through increased Stat3 activation. Publication Status: Online-Only"
> "O08915-1","RefSeq","NP_057875.1","24662816","Results provide novel evidence that AIP has an important role in the regulation of cAMP synthesis."
> "O08915-1","RefSeq","NP_057875.1","21454573","Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein"
> "O08915-1","RefSeq","NP_057875.1","21984905","XAP2 exerts a negative effect on ERalpha transcriptional activity and may thus prevent ERalpha-dependent events."
> "O08915-1","RefSeq","NP_057875.1","12482853","PPARalpha is in a complex with hsp90 and XAP2, and XAP2 appears to function as a repressor"
> "O08915-1","RefSeq","NP_057875.1","12431985","XAP2 hinders importin beta binding to the mAhR complex and represses the transactivation potential of the AhR by stabilizing the receptor complex and/or blocking nucleocytoplasmic shuttling of the AhR complex"
19661a26402
> "Q8CG14-1","RefSeq","NP_659187.2","12513694","C1r and this gene are duplicated in mice; differential expression generates alternative isomorphs in the liver and in the male reproductive system."
19662a26404
> "Q8BKD6-1","RefSeq","NP_666154.3","20615966","PIR2, by being induced by TAp73 and degrading DeltaNp73, differentially regulates TAp73/DeltaNp73 stability.[PIR2]"
19664a26407,26410
> "Q07475-1","RefSeq","NP_444308.1","27927130","P311 could accelerate skin wound reepithelialization by promoting the migration of Epidermal Stem Cell through RhoA and Rac1 activation."
> "Q07475-1","RefSeq","NP_444308.1","27939132","These studies demonstrate that P311 is required for the production of normal cutaneous scars"
> "Q07475-1","RefSeq","NP_444308.1","27906099","P311 is a novel TGFbeta1/Smad signaling-mediated regulator of transdifferentiation in epidermal stem cells during cutaneous wound healing. Publication Status: Online-Only"
> "Q07475-1","RefSeq","NP_444308.1","12417574","Role for P311 in inducing TGF-beta1-independent myofibroblast transformation"
19678a26425,26428
> "Q14AX6-1","RefSeq","NP_081228.2","30487607","CDK12 regulates DNA repair genes by suppressing intronic polyadenylation; work clarifies the function of CDK12 and underscores its potential both as a chemotherapeutic target and as a tumour biomarker"
> "Q14AX6-1","RefSeq","NP_081228.2","27073218","Report on the functions of Cdk12 during neural development in vivo, proposes a dual role for Cdk12 in neurogenesis and late stage neuronal migration via 2 distinct pathways"
> "Q14AX6-1","RefSeq","NP_081228.2","26658019","Spontaneous DNA damage was revealed by an increase in 53BP1 foci among cells cultured from Cdk12(-/-) embryos."
> "Q14AX6-1","RefSeq","NP_081228.2","24999027","The findings of this study suggest that Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression."
19681a26432,26433
> "Q8BLC3-1","RefSeq","NP_659568.2","19246390","Altered glutamatergic signaling in the prefrontal cortex of Lynx2 mutant mice contributes to increased anxiety-related behaviors"
> "Q8BLC3-1","RefSeq","NP_659568.2","16236524","Cloning and characterization of lynx2; lynx2 is expressed in a large number of neuronal structures but only in discrete postmitotic neurons"
19686a26439
> "Q8K0W9-1","RefSeq","NP_758458.1","23185508","We found that Dph3 promotes melanoma migration and invasion through the AKT signaling pathway."
19690a26444,26450
> "Q812F3-1","RefSeq","NP_083233.1","19926939","The data from this paper suggests that the hyaluronan-degrading activity of the sperm hyaluronidase HYAL5 may not be required for fertilization, at least in the mouse."
> "Q812F3-1","RefSeq","NP_083233.1","19605784","The HYAL5-deficient female mice were fully fertile and yielded normal litter sizes. HYAL5-deficient epididymal sperm is functionally normal. Thus, HYAL5 may be dispensable for fertilization."
> "Q812F3-1","RefSeq","NP_083233.1","16925524","Mouse SPAM1 and HYAL5 but not HYALP1 proteins exhibit hyaluronidase activity at neutral pH."
> "O70433-1","RefSeq","NP_034342.1","29458009","In this work, we unraveled an ambiguous role of FHL2 during influenza A virus infection in vivo. Although FHL2 restrained viral replication during the first 24 hours of infection, it significantly delayed viral clearance afterward."
> "O70433-1","RefSeq","NP_034342.1","28823868","Fhl2 anticipates the emerging inflammation and specifically the development of psoriatic arthritis by impeding the Adam17-mediated release of TNF"
> "O70433-1","RefSeq","NP_034342.1","28223370","Loss of FHL2 is associated with liver fibrosis. Publication Status: Online-Only"
> "O70433-1","RefSeq","NP_034342.1","27415427","FHL2 facilitates ovarian granulosa cell tumor progression via controlling AKT1 transcription. Publication Status: Online-Only"
19693a26454,26456
> "Q8CHD8-1","RefSeq","NP_694780.1","24576489","Results suggest that FIP3 regulates dendritic formation in the hippocampus possibly through Rab11- and Arf6-mediated endosomal trafficking"
> "Q8CHD8-1","RefSeq","NP_694780.1","20736163","CART1 might be a cytoplasmic, testis-specific derepressor of RAR [CART1, cytoplasmic adaptor for RAR and TR]"
> "Q8CHD8-1","RefSeq","NP_694780.1","15601896","Fip3 and Rab11 protein complex regulates recycling endosomes targeting to the cleavage furrow during late cytokinesis."
19700c26463
< "P70188-1","RefSeq","NP_001292572.1","16298999","Interaction of KIF3A/3B with KAP3 may be important for the proper progression of mitosis."
---
> "P05533-1","RefSeq","NP_034868.1","30018139","Colony-forming unit assays revealed that CFU-granulocyte-macrophage formation of bone marrow cells from Fpr2(-/-) mice was significantly reduced. After heat-inactivated bacterial stimulation in the airway, the expansion of c-kit(+) Sca-1(+) cells in bone marrow and recruitment of Ly6G(+) cells to the lungs and CD11b(+)Ly6C(+)TNFalpha(+) cells to the spleen of Fpr2(-/-) mice was significantly reduced. Erratum:[J Biol Chem. 2018 Oct 19;293(42):16175. PMID: 30341215]"
19713,19716c26476,26487
< "O09012-1","RefSeq","NP_001264734.1","26086376","Monoubiquitination of the N-terminal cysteine of peroxisome-associated PEX5 not only functions to recycle the peroxin back to the cytosol, but also serves as a quality control mechanism to eliminate peroxisomes with a defective protein import machinery"
< "O09012-1","RefSeq","NP_001264734.1","22458306","Demyelination in cerebellum and brain stem preceded major myelin loss in corpus callosum of Pex5 deficient mice. Publication Status: Online-Only"
< "P47757-1","RefSeq","NP_001032850.1","20969875","Capping protein interacts with both actin protomers at the barbed end of the filament, and the amphipathic helix at the C-terminus of the beta-subunit binds to the hydrophobic cleft on actin."
< "P47757-1","RefSeq","NP_001032850.1","19806181","Capzb2 plays an important role in growth cone formation and neurite outgrowth and that the underlying mechanism may involve direct interaction between Capzb2 and microtubules."
---
> "Q8BUD0-1","RefSeq","NP_783599.1","29894771","Results indicate that GPR4 is expressed by multiple neuronal populations and endothelium and that its pH sensitivity is affected by level of expression and l-lactic acid (LL). GPR4 antagonist NE 52-QQ57 blunts hypercapnic response to CO2 but this effect is absent under anaesthesia, possibly due to the inhibitory effect of LL on GPR4."
> "Q8BUD0-1","RefSeq","NP_783599.1","29089376","GPR4 blockade attenuated renal injury after IR and reduced the cell apoptosis through the suppression of CHOP expression. Publication Status: Online-Only"
> "Q8BUD0-1","RefSeq","NP_783599.1","27940273","GPR4 deficiency reduces acute intestinal inflammation in a mouse colitis model. GPR4 gene expression is upregulated in inflamed mouse and human intestinal tissues."
> "Q8BUD0-1","RefSeq","NP_783599.1","27681561","Collectively, these results posit the acid sensor GPR4 as a novel component of central blood pressure control through interactions with the renin-angiotensin system."
> "Q8BUD0-1","RefSeq","NP_783599.1","21917373","Findings suggest that GPR4 activation by an acidic pH inhibits tumor cell migration and invasion, and the Rho GTPase is at least partly responsible for this phenotype"
> "Q8BUD0-1","RefSeq","NP_783599.1","20798260","PH sensor with an important role in regulating acid secretion in the kidney collecting duct"
> "Q8BUD0-1","RefSeq","NP_783599.1","17145776","These results suggest that GPR4 deficiency leads to partially penetrant vascular abnormalities during development and that this receptor functions in blood vessel pH sensing."
> "P13634-1","RefSeq","NP_033929.2","23256642","Over-expression of CA1 may aggravate joint inflammation and tissue destruction in the transgenic mice. Publication Status: Online-Only"
> "Q5DU00-1","RefSeq","NP_808245.2","25130614","Behavioral results revealed deficits in rapid auditory processing, working memory and reference memory in Dcdc2(del2/del2) mice when compared with matched wild types."
> "Q5DU00-1","RefSeq","NP_808245.2","24094509","Results link the function of the dyslexia-associated gene Dcdc2 to spike timing through activity of N-methyl-D-aspartate receptor (NMDAR)"
> "Q5DU00-1","RefSeq","NP_808245.2","21883923","Heterozygous and homozygous mutations of Dcdc2 result in persistent visuo-spatial memory deficits, as well as visual discrimination and long-term memory deficits"
> "Q5DU00-1","RefSeq","NP_808245.2","21689730","These results indicate that Dcdc2 is not required for neurogenesis, neuronal migration or differentiation in mice, but may have partial functional redundancy with doublecortin."
19721a26493,26495
> "Q7TQN3-1","RefSeq","NP_861540.2","30814254","Results indicate that both WFIKKN and follistatin utilize their FSDs to block the type II receptor but do so via different binding interactions."
> "Q7TQN3-1","RefSeq","NP_861540.2","20164830","Taken together, this study provides evidence that GASP1 regulates CB1 receptor downregulation in vivo, and that postendocytic receptor trafficking has a key role in the development of tolerance to WIN55,212-2."
> "Q7TQN3-1","RefSeq","NP_861540.2","12595574","Report of the identification of growth and differentiation factor-associated serum protein-1 (GASP-1) associated with endogenous myostatin in normal serum"
19724a26499,26505
> "Q8K5B9-1","RefSeq","NP_694749.1","11960710","Tex1 may play a crucial role during mouse spermatogenesis"
> "O35298-1","RefSeq","NP_036184.1","30021797","By inactivating commensal LPS, AOAH thus prevents desensitization of lung epithelial cells. An enzyme that prevents severe lung inflammation/injury in Gram-negative bacterial pneumonia has the seemingly paradoxical effect of predisposing to a Th2-mediated airway disease."
> "O35298-1","RefSeq","NP_036184.1","29118019","AOAH modulates pelvic pain severity, suggesting that allelic variation in Aoah influences pelvic pain in interstitial cystitis."
> "O35298-1","RefSeq","NP_036184.1","28622363","Alveolar macrophages increase AOAH expression upon exposure to lipopolysaccharide and that Aoah+/+ mice recover more rapidly than do Aoah-/- mice from acute lung injury induced by nasally instilled lipopolysaccharide or Klebsiella pneumonia. Publication Status: Online-Only"
> "O35298-1","RefSeq","NP_036184.1","18779055","Recovery from the tolerant state induced by Gram-negative bacteria is greatly delayed in in mice that lack AOAH, a lipase that partially deacylates the bacterial cell-wall lipopolysaccharide."
> "O35298-1","RefSeq","NP_036184.1","15155618","Produced by renal cortical tubule cells and secreted into urine, where it can deacylate lipopolysaccharides, a mechanism to limit inflammatory response to gram-negative bacteria in urinary tract"
> "P97447-1","RefSeq","NP_034341.2","30260394","Mutant mice harboring the missense mutation p.W122S in Fhl1 gene developed late-onset cardiac dysfunction without skeletal myopathy"
19726a26508
> "Q8BMK0-1","RefSeq","NP_653110.3","26220856","Cep85 is a bona fide Nek2A-binding partner that surrounds the proximal ends of centrioles where it cooperates with PP1gamma (also known as PPP1CC) to antagonize Nek2A Erratum:[J Cell Sci. 2015 Oct 15;128(20):3837. PMID: 26471995]"
19729a26512
> "O08792-1","RefSeq","NP_034225.1","27923061","We show that SIX1 binds to adipogenic and brown marker genes and interacts with C/EBPa, C/EBPb and EBF2, suggesting their functional cooperation during adipogenesis. Publication Status: Online-Only"
19752a26536,26537
> "Q6PB60-1","RefSeq","NP_937804.1","23391701","Our data suggests that in vivo overexpression of neuronal p60TRP significantly affects cognitive and neuroprotective capacities."
> "Q6PB60-1","RefSeq","NP_937804.1","22172954","In vivo neural over-expression of transgenic p60TRP with its neuroprotective therapeutic potential significantly affects cardiovascular capacities."
19765a26551,26553
> "Q9QYA2-1","RefSeq","NP_058567.2","23626796","The interaction of alpha-Syn with the mitochondrial protein import machinery, in particular Tom40, might be an upstream event in alpha-Syn-induced neurotoxicity. Publication Status: Online-Only"
> "Q9QYA2-1","RefSeq","NP_058567.2","11768756","Imported into the outer mitochondrial membrane"
> "Q99J27-1","RefSeq","NP_056543.2","27935820","SLC33A1 can negatively regulate BMP signaling in mice."
19770c26558,26561
< "Q8CDP0-1","RefSeq","NP_001276585.1","25103237","CCP2 and CCP3 are deglutamylases and are highly regulated proteins confined to ciliated tissues."
---
> "Q9JII1-1","RefSeq","NP_149125.1","29626185","The expression levels of the INPP5E gene in NTD mouse embryos were significantly lower compared with control embryos, at the time of neural tube closure (gestational day 11.5). The INPP5E gene regulates the process of embryonic neural development. Abnormal levels of expression of the INPP5E gene may contribute to NTDs. Publication Status: Online-Only"
> "Q9JII1-1","RefSeq","NP_149125.1","29140789","It postulates a three-step mechanism regulating ciliary localization of INPP5E, consisting of farnesylation- and PDE6delta-mediated targeting, INPP5E-PDE6delta complex diffusion into the cilium with transfer to the IFT system, and retention inside cilia."
> "Q9JII1-1","RefSeq","NP_149125.1","28650469","Therefore our study identifies a compartmentalized PtdIns(3,4,5)P3/AKT/GSK3beta signaling axis at cilia in SHH-dependent medulloblastoma that is regulated by INPP5E to maintain tumor cell cilia, promote SHH signaling and thereby medulloblastoma progression."
> "O88735-1","RefSeq","NP_032661.2","22425998","Identification of the microtubule-associated protein ensconsin (Ens)/microtubule-associated protein 7 (MAP7) and kinesin heavy chain (Khc)/Kif5b as essential, evolutionarily conserved regulators of myonuclear positioning in Drosophila and cultured mammalian myotubes Publication Status: Online-Only"
19772a26564
> "Q8R205-1","RefSeq","NP_598764.1","29507079","Our study identifies Zc3h10 as a novel mitochondrial regulator."
19780a26573
> "Q7TPG6-1","RefSeq","NP_899047.1","22426341","The data suggest that TAFA-3 is a signaling molecule from the hypophysial pars tuberalis."
19787,19790c26580,26586
< "Q920R0-1","RefSeq","NP_001153420.2","27439389","Two ALS-linked factors, SQSTM1 and ALS2, have distinct but additive protective roles against mutant SOD1-mediated toxicity by modulating neuronal proteostasis possibly through the autophagy-endolysosomal system."
< "Q920R0-1","RefSeq","NP_001153420.2","26755825","By taking advantage of this CSMN reporter line of AlsinKO, authors reveal that apical dendrite degeneration is a common cellular pathology for CSMN that become diseased for different causes."
< "Q920R0-1","RefSeq","NP_001153420.2","22982304","Alsin and spartin may interact each other physically."
< "Q920R0-1","RefSeq","NP_001153420.2","21937428","Alsin and SOD1(G93A) proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicity."
---
> "P34960-1","RefSeq","NP_032631.3","30959793","Reduced astrogliosis in Mmp12(-/-) mice was associated with a reduced density of activated/reactive microglia and a trend for a reduced density of M1 cells. Publication Status: Online-Only"
> "P34960-1","RefSeq","NP_032631.3","30510003","High MMP12 expression is associated with emphysema development in Chronic obstructive pulmonary disease."
> "P34960-1","RefSeq","NP_032631.3","29722565","MMP-12 can increase the expression of PGF by increasing early-growth response protein 1 (Egr-1) level through the activation of protease-activated receptor 1 (PAR-1). The PGF-mediated downstream signaling molecules drive caspase-3 and caspase-9-dependent apoptosis in bronchial epithelial cells."
> "Q8BR65-1","RefSeq","NP_848737.3","23123966","These data define a role for Suds3 in activation of FGF4/ERK signaling."
> "Q8BR65-1","RefSeq","NP_848737.3","22716292","The identification of Sds3 (suppressor of defective silencing 3) as an adaptor protein that recruits the Sin3 [SWI (switch)-independent 3]-HDAC (histone deacetylase) repression complex and binds Foxk1."
> "Q8BR65-1","RefSeq","NP_848737.3","16767157","Capacity of mSds3 to cooperate with p53 deficiency in cancer predisposition relates to its specific role in chromosome segregation, rather than its central role in maintaining a functional mSin3A complex"
> "Q8BR65-1","RefSeq","NP_848737.3","14522945","MSds3 and its associated mSin3/HDAC components play a central role in initiating the cascade of pericentric heterochromatin-specific modifications necessary for the proper distribution of chromosomes during cell division in mammalian cells."
19791a26588,26589
> "P21836-1","RefSeq","NP_033729.1","30076217","In melanoma, MITF overexpression induced ACHE transcription, and mutation of an E-box site in human ACHE promoter blocked this induction"
> "P21836-1","RefSeq","NP_033729.1","29263397","Loss of acetylcholinesterase activity with mitochondrial dysfunction is associated with hypercholesterolemia. Publication Status: Online-Only"
19793a26592,26593
> "O35885-1","RefSeq","NP_032580.2","30096149","ASCL2 is required for the emergence or early maintenance of glycogen trophoblast cells during development. Publication Status: Online-Only"
> "O35885-1","RefSeq","NP_032580.2","7773285","Mash2 gene is preferentially expressed from the paternal allele."
19801a26602,26608
> "Q3UJD6-1","RefSeq","NP_663382.2","30386869","USP19 is an important regulator of fat development. Its inactivation in mice exerts effects on multiple tissues, which may protect against the negative metabolic effects of high-fat feeding."
> "Q3UJD6-1","RefSeq","NP_663382.2","29901692","USP19 modulates GR levels and in so doing may modulate both insulin and glucocorticoid signaling, two critical pathways that control protein turnover in muscle and overall glucose homeostasis."
> "Q3UJD6-1","RefSeq","NP_663382.2","28886438","Data suggest that expression of Usp19 in skeletal muscle can be regulated by dietary factors; here, supplementation with phytoestrogen daidzein down-regulates Usp19 expression via Esrb signaling and increases skeletal muscle mass. (Usp19 = ubiquitin-specific peptidase 19; Esrb = estrogen receptor beta)"
> "Q3UJD6-1","RefSeq","NP_663382.2","26048142","Expression of USP19 correlates with that of MuRF1 and MAFbx/atrogin-1 in skeletal muscles"
> "Q3UJD6-1","RefSeq","NP_663382.2","25568336","Deubiquitination by USP19 does modulate muscle cell differentiation and that this function requires the ER-localized isoform and appears to act through regulation of the unfolded-protein response (UPR) signaling."
> "Q3UJD6-1","RefSeq","NP_663382.2","21971047","E2 induces USP19 expression through nuclear ERalpha, (ii) increased USP19-mediated deubiquitinating activity represses myogenesis, and (iii) ERbeta inhibits ERalpha-activated USP19 expression."
> "Q3UJD6-1","RefSeq","NP_663382.2","19015242","Study reports that the USP19 deubiquitinating enzyme interacts with and stabilizes KPC1, thereby modulating p27(Kip1) levels and cell proliferation Erratum:[Mol Cell Biol. 2009 Jun;29(11):3241]"
19803a26611,26615
> "Q8VE49-1","RefSeq","NP_001292191.1","26914863","The proliferation and migration of granule cells was delayed after P15 in Duoxa-/- mice. However, these changes disappeared by P25. Although the cerebellar structure of Duoxa-/- mice was not significantly different from that of Wt mice at P25, motor coordination was impaired. It was also found that the amplitude of paired-pulse facilitation at parallel fiber-Purkinje cell synapses decreased in Duoxa-/- mice."
> "Q8VE49-1","RefSeq","NP_001292191.1","24410844","DUOXA1 overexpression in muscle stem cells induces apoptosis and inhibits differentiation through DUOX1 and ASK1. Publication Status: Online-Only"
> "Q8VE49-1","RefSeq","NP_001292191.1","21362455","DUOXA1 is a novel p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation."
> "Q8VE49-1","RefSeq","NP_001292191.1","20233719","Nip1 has an important role in the guidance of neuronal differentiation through ROS generation and modulation of intermediate filaments"
> "Q9QZ09-1","RefSeq","NP_038657.2","15601915","Neither FEM1B nor PHTF1 are directly implicated in apoptosis in testis tissue"
19811a26624,26626
> "O08677-1","RefSeq","NP_075614.1","29540224","Schistosome tegument contains two cysteine proteases belonging to the calpain family (SmCalp1 and SmCalp2) and these are likely responsible for the high molecular weight kininogen (HK) cleavage reported here. Schistosome cleavage of HK should help impede blood clotting and inflammation around the worms in vivo and so promote their ease of movement within the vasculature of their hosts. Publication Status: Online-Only"
> "O08677-1","RefSeq","NP_075614.1","14506238","His-Gly-Lys motif and lysine residue (Lys487) play essential roles in inhibition of cell adhesion and invasion in vitro and in prevention of metastasis of cancer cells in vivo"
> "O08677-1","RefSeq","NP_075614.1","12023845","Domain 5 of kininogen was identified as an anti-adhesive component with a potent anti-inflammatory action in a peritonitis mouse model. Review article"
19818a26634,26635
> "P56394-1","RefSeq","NP_001017429.1","12370308","Cox17 has a role in activating cytochrome c oxidase in mice"
> "P56394-1","RefSeq","NP_001017429.1","11997103","Sp1, NRF-1 and NRF-2 are involved in basal transcription, similar to the transcription mechanism of other CCO-related genes"
19828a26646,26648
> "P23798-1","RefSeq","NP_033571.1","28780076","BMI1 and MEL18 contribute to the development of colitis-associated cancer in mice by promoting proliferation and reducing apoptosis via suppressing expression of Reg3b. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells."
> "P61213-1","RefSeq","NP_031513.1","12781685","This gene was a target of WNT signlaing in the dorsal somite."
> "P61213-1","RefSeq","NP_031513.1","11909968","Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene."
19839a26660,26665
> "Q8BMS9-1","RefSeq","NP_780654.1","22227519","These observations indicate that RASSF2 regulates osteoblast and osteoclast differentiation by inhibiting NF-kappaB signalling via association with IkappaB kinase (IKK) alpha and beta forms and suppression of IKK activity."
> "Q91VN1-1","RefSeq","NP_067534.2","23755975","ZFP191 played an essential role in aggressive proliferation and migration of vascular smooth muscle cells, which in turn facilitated intimal hyperplasia."
> "Q91VN1-1","RefSeq","NP_067534.2","22183946","The loss of Zfp191 may suppress systemic inflammation by reducing these cytokine levels during lipopolysaccharide-induced endotoxic shock. Publication Status: Online-Only"
> "Q91VN1-1","RefSeq","NP_067534.2","20080941","This study demonstrates that ZFP191 is required for the myelinating function of differentiated oligodendrocytes."
> "E9PY46-1","RefSeq","NP_598887.3","29195058","In a mouse model, results suggest that cilia gene IFT140 is essential in promoting dentin formation and reparation."
> "E9PY46-1","RefSeq","NP_598887.3","29236364","Findings demonstrate that IFT140 is a key regulator for male fertility and normal spermiogenesis in mice. It not only plays a role in sperm flagella assembling, but is also involved in critical assembly of proteins that interface between the germ cell plasma and the Sertoli cell."
19851,19854d26676
< "Q9WVG6-1","RefSeq","NP_067506.2","30550788","CARM1 accumulates in nuclear granules at the 2- to 4-cell stage transition in the mouse embryo, with the majority corresponding to paraspeckles. The paraspeckle component Neat1 and its partner p54nrb are required for CARM1's association with paraspeckles and for H3R26 methylation."
< "Q9WVG6-1","RefSeq","NP_067506.2","30391528","Study shows that peripheral nerve injury induced the upregulation of the mRNA and protein expression of coactivator-associated arginine methyltransferase 1 (CARM1) in the injured dorsal root ganglion. Findings suggest that CARM1 may serve as a promising therapeutic target for neuropathic pain treatment in clinical applications."
< "Q9WVG6-1","RefSeq","NP_067506.2","30366907","C9orf72 acts by promoting the lysosomal degradation of coactivator-associated arginine methyltransferase 1 (CARM1), which in turn regulates autophagy-lysosomal functions and lipid metabolism."
< "Q9WVG6-1","RefSeq","NP_067506.2","30153436","Our data demonstrate that CARM1 is required for transcriptional activation of a subset of RA target genes, and we uncover changes in the recruitment of Suz12 and the epigenetic H3K27me3 and H3K27ac marks at gene regulatory regions for CRABP2 and NR2F1 during RA-induced differentiation."
19856,19860c26678,26680
< "Q61142-1","RefSeq","NP_001269957.1","23894536","Spin1 regulates maternal transcripts post-transcriptionally and is involved in meiotic resumption Publication Status: Online-Only"
< "Q61142-1","RefSeq","NP_001269957.1","21960006","Spindlin1 localizes to the active ribosomal DNA (rDNA) repeats, and Spindlin1 facilitates the expression of ribosomal RNA genes. Publication Status: Online-Only"
< "Q61142-1","RefSeq","NP_001269957.1","18645677","Spin1 isoform2 is a protein expressed highly in adult testis, which might be involved in spermatogenesis and could be necessary for normal sperm motility"
< "Q61142-1","RefSeq","NP_001269957.1","18201843","SPINDLIN1 is an important gene for mammalian mitotic chromosome functions, and disrupted regulation results in abnormal cell division, a mechanism that may be involved in tumorigenesis"
< "Q61142-1","RefSeq","NP_001269957.1","16098913","Spindlin1 gene may contribute to tumorigenesis"
---
> "Q8BX07-1","RefSeq","NP_666124.1","25990325","CTDSP2 induces p21(Cip1/Waf1) through increasing the activity of Ras."
> "Q8CGA3-1","RefSeq","NP_775564.1","25480797","Mice lacking Lat4 display a slight intrauterine growth restriction, postnatal malnutrition and early death."
> "Q8CGA3-1","RefSeq","NP_775564.1","15659399","In situ hybridization experiments show that LAT4 mRNA is restricted to the epithelial cells of the distal tubule and the collecting duct in the kidney. In the intestine, LAT4 is mainly present in the cells of the crypt."
19863a26684,26687
> "Q61955-1","RefSeq","NP_032966.1","22520925","Letter: NGF-p75 and neuropsin/KLK8 pathways may cooperate in regulation of epidermal homeostasis in inflamed skin."
> "Q61955-1","RefSeq","NP_032966.1","22358061","Klk8 is involved in the proliferation and migration of keratinocytes through Klk6 in the early stages of wound healing, and possibly in keratinocyte differentiation associated with the upregulation of PAR2 in the late stages of wound healing."
> "P26048-1","RefSeq","NP_032092.1","30087324","Gabra2-1 mice display spontaneous seizures during development, accompanied by early mortality Publication Status: Online-Only"
> "P97429-1","RefSeq","NP_038499.2","26023182","These results suggest that AnxA4 is a novel direct negative regulator of AC5, adding a new facet to the functions of annexins."
19873a26698,26701
> "O88844-1","RefSeq","NP_034627.3","29719265","Findings support the hypothesis that IDH1(R132H) promotes glioma development."
> "O88844-1","RefSeq","NP_034627.3","29355841","Combined expression of Jak2V617F and mutant IDH1R132H or Idh2R140Q induces myeloproliferative neoplasm progression, alters stem/progenitor cell function, and impairs differentiation Erratum:[J Clin Invest. 2018 Oct 1;128(10):4743. PMID: 30222137]"
> "O88844-1","RefSeq","NP_034627.3","29097607","IDH1 expression regulates TCA cycle in glioma and affects glioma cell growth.GDH2 promotes growth of IDH1-expressing gliomas."
> "O88844-1","RefSeq","NP_034627.3","28663574","Vitamin C treatment induced an IDH1(R132H)-dependent reduction in cell proliferation."
19883a26712,26717
> "Q62417-1","RefSeq","NP_001030136.1","30068914","These observations reveal a critical role of vinexin alpha and CAP in mechanotransduction and MSC differentiation. Publication Status: Online-Only"
> "Q62417-1","RefSeq","NP_001030136.1","27449513","The first SNP rs29972765 is located in a gene desert on chromosome 18, about 72 kb upstream of Skor2 . The second SNP rs30415957 resides in the intron of Plce1.The remaining two SNPs (rs30768258 and rs31216810) are close to each other on chromosome 19, in the vicinity of Sorbs1.  Knockdown of Sorbs1 by siRNA attenuates the induction of differentiation marker gene Prl8a2 Publication Status: Online-Only"
> "Q62417-1","RefSeq","NP_001030136.1","26527617","The study screened CrkL binding proteins using RNA interference (RNAi) and identified Sorbs1 and Sorbs2 as two proteins that are enriched at AChR clusters and are required for the formation of AChR aggregation in vitro. Publication Status: Online-Only"
> "O88329-1","RefSeq","NP_001074688.1","26286357","Myo1a and Myo6 play essential roles in response to intestinal mucosal injury"
> "O88329-1","RefSeq","NP_001074688.1","22510086","The data indicates that Myo1a is an important regulator of CFTR traffic and anion transport in the brush border membrane of villus enterocytes."
> "O88329-1","RefSeq","NP_001074688.1","11739797","Actin filaments and myosin I alpha cooperate with microtubules for the movement of lysosomes"
19911a26746,26748
> "P17012-1","RefSeq","NP_035898.2","28251288","Our findings show that RNAi-mediated disruption of Zfx/Zfy in mouse testis affected X/Y spermatogenesis. Additionally, results suggest that the paralogous genes Zfx/Zfy play an important role in the process of X and Y sperm development. The individual interference of Zfx/Zfy may predict the outcome of X and Y haploid sperms. Presented herein is an advanced method developed to control mouse X/Y spermatogenesis and sex rati"
> "P17012-1","RefSeq","NP_035898.2","25164012","Zfx is a common cell-intrinsic regulator of diverse Hedgehog-induced tumors."
> "P17012-1","RefSeq","NP_035898.2","24485662","Zfx, a transcription factor that controls hematopoietic stem cell self-renewal, controls the initiation and maintenance of acute myeloid leukemia."
19913a26751,26754
> "Q8K402-1","RefSeq","NP_851836.2","18948418","Mn1 and Tbx22 function in a novel molecular pathway regulating mammalian palate development."
> "Q8K402-1","RefSeq","NP_851836.2","12666195","In mouse embryos, it is expressed in distinct areas of the head, namely the mesenchyme of the inferior nasal septum, the posterior palatal shelf before fusion, the attachment of the tongue, and mesenchymal cells surrounding the eye anlage."
> "Q8K402-1","RefSeq","NP_851836.2","12412015","Primary role for Tbx22 in both palate and tongue development"
> "Q8K402-1","RefSeq","NP_851836.2","12374769","Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia (CPX) phenotype observed in CPX patients."
19918a26760
> "O55176-3","RefSeq","NP_032879.2","28067271","Praja1 promotes skeletal myogenesis through degradation of EZH2 upon p38alpha activation. Publication Status: Online-Only"
19924a26767,26768
> "Q64326-1","RefSeq","NP_032586.1","28146118","JDP2 acts as a novel transcriptional activator of the mouse Mc2r gene, suggesting that JDP2 may have physiological functions as a novel player in MC2R-mediated steroidogenesis as well as cell signaling in adrenal glands. Publication Status: Online-Only"
> "Q64326-1","RefSeq","NP_032586.1","17170082","MC2-R gene is regulated both transcriptionally and post-transcriptionally during adipogenesis"
19947,19951d26790
< "Q8CBR1-1","RefSeq","NP_001272717.1","28461473","In cultured renal epithelial cells normally lacking the expression of Ildr1, overexpression of Ildr1 significantly reduces the paracellular water permeability. Together, study provides a mechanism of how cells transport water."
< "Q8CBR1-1","RefSeq","NP_001272717.1","25822906","The angulin-2/ILDR1 deficiency causes the postnatal degenerative loss of hair cells in the cochlea. Publication Status: Online-Only"
< "Q8CBR1-1","RefSeq","NP_001272717.1","25217574","Study consolidate the importance of ILDR1 as a tight junction protein necessary for cochlear hair cells survival, and the integrity of the auditory system."
< "Q8CBR1-1","RefSeq","NP_001272717.1","23863714","ILDR1 regulates CCK release through a mechanism dependent on fatty acids and lipoproteins."
< "Q8CBR1-1","RefSeq","NP_001272717.1","23239027","The findings show the heterogeneity of the molecular organization of tTJs in terms of the content of LSR, ILDR1 or ILDR2, and suggest that ILDR1-mediated recruitment of tricellulin to TCs is required for hearing. Erratum:[J Cell Sci. 2013 Aug 15;126(Pt 16):3797]"
19976a26816
> "P97291-1","RefSeq","NP_031693.2","30315415","Cdh8 has role in neurogenesis in the ventral telencephalon during development."
19979a26820
> "P43404-1","RefSeq","NP_033565.2","29980684","Hypomorphic alleles of Zap70 or chemical inhibition of Zap70 catalysis leads to an increase of IFN-gamma-producing invariant natural killer T cells. Publication Status: Online-Only"
19989,19990c26830
< "Q8CC88-1","RefSeq","NP_082182.1","29660410","Analyses indicate that the mouse Vwa8 gene produces two transcripts; the full-length Vwa8a is highly expressed relative to the truncated Vwa8b transcript across all developmental time points and tissues analyzed.These data establish the development timeline and expression profile for both Vwa8a and Vwa8b."
< "Q8CC88-1","RefSeq","NP_082182.1","28414126","The VWA8 protein was targeted exclusively to mitochondria in mouse AML12 liver cells, and this was prevented by deletion of the targeting sequence."
---
> "Q9D0F3-1","RefSeq","NP_081676.1","29735583","MCFD2-deficient mice generated by gene targeting also demonstrate reduced plasma FV and FVIII, with levels lower than those in LMAN1-deficient mice, similar to previous observations in LMAN1- and MCDF2-deficient humans."
19995a26836,26838
> "Q8CFG0-1","RefSeq","NP_082348.2","28657777","Sulfate 6-O-endosulfatase 2 expression in type II alveolar epithelial cells plays a protective role in epithelial injury, inflammation and mortality"
> "Q8CFG0-1","RefSeq","NP_082348.2","28490013","Shh signaling requires the coordinated activity of Sulf1 and Sulf2 in order to reach that threshold in the mouse ventral spinal cord"
> "Q8CFG0-1","RefSeq","NP_082348.2","12368295","Sulfs are extracellular endosulfatases with strong potential for modulating the interactions of heparan sulfate proteoglycans in the extracellular microenvironment"
20004a26848,26851
> "Q922U1-1","RefSeq","NP_081817.2","25111227","The mouse retinal pigment epithelium (RPE)is the primary cell affected by mutations in the RNA splicing factors (PRPF3, PRPF8, and PRPF31), and these changes occur at an early age."
> "Q922U1-1","RefSeq","NP_081817.2","21283520","Analyzed the spatial and temporal expression of the PRPF3 gene in mice and found that it is highly expressed in retinal cells relative to other tissues and its expression is developmentally regulated Publication Status: Online-Only"
> "Q922U1-1","RefSeq","NP_081817.2","20811066","The finding of similar degenerative changes in RPE cells of all three mouse models suggests that the retinal pigment epithelium may be the primary cell type affected in the RNA splicing factor forms of retinitis pigmentosa. Publication Status: Online-Only"
> "Q922U1-1","RefSeq","NP_081817.2","18395097","TASP1, EPS15R, and PRPF3 expression were significantly induced in HCCs of transgenic EGF2B mice as was P2 promoter-driven HNF4alpha"
20011a26859
> "Q8BKC8-1","RefSeq","NP_780565.2","23541637","Oijbih iuhg iugh uh jkgh uib"
20018a26867
> "Q8C010-1","RefSeq","NP_001292390.1","21971119","These findings suggest that GPR61 is involved in the regulation of food intake and body weight"
20029,20030c26878,26888
< "Q9QZS3-1","RefSeq","NP_001129547.1","30262992","Data show the expression of Zeb1 and Numb were both significantly higher in LLC-symmetric cell division than LLC-asymmetric cell division cells. Publication Status: Online-Only"
< "Q9QZS3-1","RefSeq","NP_001129547.1","14641329","MNumb splicing isoform has an inhibitory effect on Notch signaling, indicating its potential roles in the differentiation of pancreatic endocrine lineage."
---
> "O89086-1","RefSeq","NP_001159883.1","30037926","Mechanistically, RBM3 binds to Yap1-3'UTR, regulates its stability, and affects the expression of YAP1. RBM3 and YAP1 overexpression can partially rescue the brain development defect caused by RBM3 knockout in cold stress."
> "O89086-1","RefSeq","NP_001159883.1","29743635","Novel functions of RBM3 of potential significance to tissue repair, metastasis and development Publication Status: Online-Only"
> "O89086-1","RefSeq","NP_001159883.1","29505791","RBM3 regulates osteoblast differentiation through the ERK signaling pathway."
> "O89086-1","RefSeq","NP_001159883.1","30051360","Overexpression of RBM3 also attenuated muscle atrophy in rat soleus muscle undergoing disuse atrophy. These findings provide direct evidence for a novel role of RBM3 in inducing hypertrophy as well as attenuating atrophy."
> "Q920G3-1","RefSeq","NP_663556.1","27524237","Immunohistochemical analysis of the Peyer's patches (PPs) tissue sections shows that Siglec-F is expressed on the surface of the Intestinal microfold (M) cell membrane exposed to the intestinal lumen."
> "Q920G3-1","RefSeq","NP_663556.1","25497369","These data identify a previously unrecognized endogenous anti-inflammatory property of airway mucins by which their glycans can control lung eosinophilia through engagement of Siglec-F."
> "Q920G3-1","RefSeq","NP_663556.1","24698729","Depending on the nature of the allergy model used, the negative regulatory role of siglec-F on eosinophilia may be overridden."
> "Q920G3-1","RefSeq","NP_663556.1","23880769","Neither KSGal6ST nor C6ST-1 is required for Siglec-F ligand synthesis in leukocytes or lung tissue"
> "Q920G3-1","RefSeq","NP_663556.1","23840825","Engagement of Siglec-F induced mouse eosinophil apoptosis that was modest in magnitude and dependent on caspase activity. Publication Status: Online-Only"
> "Q920G3-1","RefSeq","NP_663556.1","17272508","Negative feedback role for Siglec-F in regulating the pathogenesis of human eosinophil-mediated disorders."
> "Q920G3-1","RefSeq","NP_663556.1","14559209","We detected expression of mSiglec-5 (or -F), -10, and -E mRNA in purified mouse eosinophils"
20038a26897,26901
> "Q99PT1-1","RefSeq","NP_598557.3","26971292","The siRNA-mediated suppression of expression of alphaGDI especially affected vesicle dynamics."
> "Q99PT1-1","RefSeq","NP_598557.3","26726844","GDIalpha has a critical role in suppressing Rac1 activity in mature podocytes"
> "Q99PT1-1","RefSeq","NP_598557.3","25666508","Integrin beta 8 and PTP-PEST form protein complexes at the leading edge of migrating cells and balance patterns of Rac1 and Cdc42 signaling by controlling the subcellular localization and phosphorylation status of Rho GDP dissociation inhibitor 1."
> "Q99PT1-1","RefSeq","NP_598557.3","25164814","RhoGDalpha controls ENaC expression and activity via Rac1."
> "Q99PT1-1","RefSeq","NP_598557.3","11923206","Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation."
20041a26905,26909
> "Q8BFY0-1","RefSeq","NP_848771.1","29724821","Using comparative electrophysiology experiments, the study identified species-dependent differences between the human and mouse TRPM8-PIRT complexes. It found that human PIRT attenuated human TPRM8 conductance, unlike mouse PIRT, which enhanced mouse TRPM8 conductance."
> "Q8BFY0-1","RefSeq","NP_848771.1","29808083","Results show that mechanical allodynia and thermal hyperalgesia were alleviated in Pirt-/- mice in chronic constriction injury (CCI) model. Taken together, Pirt together with transient receptor potential vanilloid channel 1 is involved in CCI-induced neuropathic pain. Publication Status: Online-Only"
> "Q8BFY0-1","RefSeq","NP_848771.1","23863968","Pirt regulates the function of TRPM8 and its role in detecting cold."
> "Q8BFY0-1","RefSeq","NP_848771.1","21655234","Pirt contributes to both histaminergic and nonhistaminergic itch and, crucially, is involved in forms of itch that are both TRPV1-dependent and -independent."
> "Q8BFY0-1","RefSeq","NP_848771.1","18455988","Pirt is a key component of the TRPV1 complex and positively regulates TRPV1 activity."
20057a26926
> "Q3UEI1-1","RefSeq","NP_963901.1","21670265","Findings identify PC2 and PDE4C as unique components of an AKAP complex in primary cilia and reveal a common mechanism for dysregulation of cAMP signaling in cystic kidney diseases arising from different gene mutations"
20060,20062d26928
< "Q3UMR0-1","RefSeq","NP_663608.3","27066885","RACK1 competes with Rab40C for binding to the ANKR2 domain of Varp and regulates dendrite outgrowth through stabilization of Varp in mouse melanocytes"
< "Q3UMR0-1","RefSeq","NP_663608.3","19403694","Varp functions as the Rab32/38 effector that controls trafficking of Tyrp1 in melanocytes."
< "Q3UMR0-1","RefSeq","NP_663608.3","16525121","Varp is a potential Rab21 guanine nucleotide exchange factor and might regulate endosome dynamics in vivo"
20068a26935
> "Q8C7J6-1","RefSeq","NP_780638.1","21452234","Data suggest that the distinct spatial and temporal distribution patterns of KCTD8, 12, 12b, and 16 underlie functional differences in native GABA(B) responses."
20073a26941,26943
> "P35846-1","RefSeq","NP_032060.2","28244241","Several experimental studies in mice and human epidemiological and genetics studies have suggested that FOLR1 abnormalities are involved in a portion of human neural tube defects (NTD), although the solo defect of FOLR1 did not cause NTD. (Review) Review article"
> "P35846-1","RefSeq","NP_032060.2","28498413","The above showed that human FRalpha based DNA vaccination with CpG oligodeoxynucleotides as an adjuvant was effective in growth inhibition of a FRalpha expressing tumor in mice and deserves further evaluation as a possible immunotherapy"
> "P35846-1","RefSeq","NP_032060.2","27580818","Midbrain dopamine neural progenitors and nascent dopamine neurons specifically express Folr1. Publication Status: Online-Only"
20075a26946,26959
> "Q9ERK9-1","RefSeq","NP_898991.1","29454075","The present study shows that sustained activation of P2Y6R may contribute to intestinal tumorigenesis by blocking the apoptotic process and by contributing to chemoresistance, a substantial concern in the treatment of patients with CRC."
> "Q9ERK9-1","RefSeq","NP_898991.1","28815725","Results demonstrated that P2Y6 signaled through Ca(2+) influx and RhoA/ROCK to reorganize cytoskeleton and promote migration in myoblasts."
> "Q9ERK9-1","RefSeq","NP_898991.1","28539604","Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6. Publication Status: Online-Only"
> "Q9ERK9-1","RefSeq","NP_898991.1","28396595","The P2Y6 receptor in the central nervous system, dorsal root ganglion, or both is involved in inhibition of bladder afferent signalling or sensitivity in the pontine micturition centre and that the receptor in the detrusor may be implicated in facilitation to sustain bladder contraction force. Publication Status: Online-Only"
> "Q9ERK9-1","RefSeq","NP_898991.1","18523137","P2Y(6)-deficient mice have a defective response to UDP in macrophages, endothelial cells, and vascular smooth muscle cells."
> "Q9ERK9-1","RefSeq","NP_898991.1","18250478","Inflammation up-regulates P2Y2 as well as P2Y6 receptor expression in the colonic mucosa of colitic mice."
> "Q80XC2-1","RefSeq","NP_796348.2","16043508","Shows conservation of the yeast TRM61 (GCD14) protein in mouse, human and Drosophila, and demonstrates functional activity of the human ortholog."
> "Q91X17-1","RefSeq","NP_033496.1","30297523","This work outlines a previously unknown role for Tamm-Horsfall Protein as an essential component for host immune defense against fungal urinary tract infection. Publication Status: Online-Only"
> "Q91X17-1","RefSeq","NP_033496.1","30216136","A biological link between salt stress in the loop of Henle and interactions between Umod and heat-shock proteins."
> "Q91X17-1","RefSeq","NP_033496.1","30139743","Increased urinary UMOD secretion in low-magnesium states reduces TRPM6 endocytosis and thereby up-regulates TRPM6 cell-surface abundance to defend against further urinary magn"
> "Q91X17-1","RefSeq","NP_033496.1","18375198","Urinary uromodulin is generated by a conserved C-terminal proteolytic cleavage and retains its entire ZP domain."
> "Q91X17-1","RefSeq","NP_033496.1","15327412","THP is a critical urinary defense factor and its deficiency could be an important contributing factor in nephrolithiasis"
> "Q91X17-1","RefSeq","NP_033496.1","14665435","Potential THP defects, either quantitative or qualitative, could predispose the urinary bladder to bacterial infections"
> "Q91X17-1","RefSeq","NP_033496.1","14871399","THP serves as a soluble receptor for type 1 fimbriated E. coli and helps eliminate bacteria from the urinary tract."
20080a26965,26968
> "Q8BVA5-1","RefSeq","NP_765989.3","30169630","We then amassed convergent genomic evidence showing population level associations between LDAHexpression and occurrence of prostate cancer . We further identified loss of LDAH in both tissues and cell lines derived from human prostate cancer, and generated Ldah-/- mouse model, which recapitulated many of the clinical findings in DGAP056. Erratum:[Hum Mol Genet. 2019 May 15;28(10):1753-1754. PMID: 31222336]"
> "Q8BVA5-1","RefSeq","NP_765989.3","27836991","Our data suggest that LDAH is not a major cholesterol ester hydrolase, and an alternative metabolic function may be responsible for its possible effect on development of prostate cancer."
> "Q8BVA5-1","RefSeq","NP_765989.3","24357060","The data identify LDAH a candidate target to promote reverse cholesterol transport from atherosclerotic lesions."
> "Q8BVA5-1","RefSeq","NP_765989.3","23525007","This study identified a novel lipid droplets -associated protein family, represented by the Drosophila protein CG9186 and its murine homolog MGI:1916082."
20085a26974,26979
> "Q8BZ03-1","RefSeq","NP_849231.1","29789568","The results indicate that down-regulation of PRKD2 is involved in the pathogenesis of hyperinsulinemia which, in turn, results in insulin resistance and metabolic disorders. Publication Status: Online-Only"
> "Q8BZ03-1","RefSeq","NP_849231.1","26045048","Our studies demonstrate that PKD1/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha effect on MVB secretory traffic."
> "Q8BZ03-1","RefSeq","NP_849231.1","25639845","Results reveal that whereas protein kinase D1 and protein kinase D2 are essential for neuronal polarity, there exists a functional redundancy between the two proteins."
> "Q8BZ03-1","RefSeq","NP_849231.1","25336615","PKD2 acted as an amplification checkpoint for antigen-stimulated digital cytokine responses and translated the differential strength of TCR signaling to determine the number of naive CD8(+) T cells that became effector cells. Publication Status: Online-Only"
> "Q8BZ03-1","RefSeq","NP_849231.1","20819079","Data demonstrate that, unlike PKD1, PKD2 catalytic activity is dispensable for normal embryogenesis."
> "Q8BZ03-1","RefSeq","NP_849231.1","17226786","PKD2, like PKD, facilitates mitogenesis in 3T3 cells"
20089a26984,26986
> "Q571K4-1","RefSeq","NP_080005.2","28462515","Findings indicate that the absence of TAB3 plays a harmful role in ischemic heart disease"
> "Q571K4-1","RefSeq","NP_080005.2","23509369","TAB2 and TAB3 are essential for B cell activation leading to antigen-specific antibody responses, as well as B-1 and marginal zone B cell development."
> "Q571K4-1","RefSeq","NP_080005.2","22660635","MiR-23b suppresses IL-17-, tumor necrosis factor alpha (TNF-alpha)- or IL-1beta-induced NF-kappaB activation and inflammatory cytokine expression by targeting TAB2, TAB3 and IKK-alpha."
20099,20101d26995
< "O35136-1","RefSeq","NP_001106679.1","26611261","Abeta-dependent disruption of NCAM2 functions in Alzheimer's disease hippocampus contributes to synapse loss. Publication Status: Online-Only"
< "O35136-1","RefSeq","NP_001106679.1","25875008","These results indicate that OCAM exerts a posttranscriptional control on the ErbB2 signalling in spinal cord stem cells. This study adds further support for considering cell adhesion molecules as regulators of the ErbB signalling Publication Status: Online-Only"
< "O35136-1","RefSeq","NP_001106679.1","25632147","This study identified the cell adhesion molecule NCAM2 as a new regulator of filopodial formation and neurite branching."
20106a27001,27016
> "P70423-1","RefSeq","NP_031541.1","25130427","Knockdown impaired AMPK-PPAR-alpha signaling and resulted in lipid accumulation under fasting"
> "P70423-1","RefSeq","NP_031541.1","16085056","In a neuronal cell model, y+,L and y+ transport systems are the predominant form of arginine uptake mechanisms and the transport of arginine is altered by membrane potential and redox factors."
> "Q7JJ13-1","RefSeq","NP_034368.2","28388437","BRD2 acts to augment the boundary function of CTCF both by limiting the spread or range of enhancer activity and by physically preventing the formation of cross-boundary contacts genome-wide."
> "Q7JJ13-1","RefSeq","NP_034368.2","28262505","Brd2 and Brd4 genetic transcription required for Th17 cell development and adaptive immunity."
> "Q7JJ13-1","RefSeq","NP_034368.2","27865874","These results provided evidence for a novel role of Brd2 in chronic inflammation and insulin resistance."
> "Q7JJ13-1","RefSeq","NP_034368.2","26804911","This study reveals an antagonistic relationship between H2A.Z.1ub and BRD2 to regulate the transcriptional balance at bivalent genes to enable proper execution of developmental programs."
> "Q7JJ13-1","RefSeq","NP_034368.2","9528865","Brd2 autophosphorylation activity is induced in mouse tissues (lung, kidney, brain, liver and heart) upon systemic treatment with the mitogens Epidermal Growth Factor or Phorbol 12-Myristate 13-Acetate."
> "Q5SVQ0-1","RefSeq","NP_808287.1","28811661","The data provides a useful resource for exploring Myst2 and Niam essential cellular functions and should contribute to deeper understanding of organism early development and survival as well as cancer. Publication Status: Online-Only"
> "Q5SVQ0-1","RefSeq","NP_808287.1","27733580","A nonredundant role for KAT7 in the maintenance of Histone h 3 lusine 14 acetylation, which is intimately linked with the ability to develop a normal immune system, is reported."
> "Q5SVQ0-1","RefSeq","NP_808287.1","26677226","These results indicate that BRPF3 forms a functional tetrameric complex with HBO1 but is not required for mouse development and survival"
> "Q5SVQ0-1","RefSeq","NP_808287.1","26072331","Taken together, MYST2 is a repressed growth suppressor in AML mediating reduced acetylation of histone 4 at residue 5"
> "Q5SVQ0-1","RefSeq","NP_808287.1","18029353","FAD24 controls DNA replication by recruiting HBO1 to origins of DNA replication and is required for MCE during adipocyte differentiation."
> "Q5SVQ0-1","RefSeq","NP_808287.1","17954561","Reveal a direct regulatory connection between p53-responsive stress signaling and Hbo1-dependent chromatin pathways"
> "Q1ERP8-1","RefSeq","NP_082263.2","24376728","Nepmucin/CD300LG expression in microvascular endothelial cells Publication Status: Online-Only"
> "Q1ERP8-1","RefSeq","NP_082263.2","18675811","These results suggest that endothelial nepmucin promotes lymphocyte transendothelial migration using multiple adhesion pathways."
> "Q1ERP8-1","RefSeq","NP_082263.2","16754720","Nepmucin may serve as a dual-functioning in peripheral node addressin in endothial venules mediating both lymphocyte rolling and binding via different functional domains."
20109a27020,27023
> "Q9R0U0-1","RefSeq","NP_034308.1","26586428","SRSF10 represses inclusion of PGC1alpha exon 7a."
> "Q9R0U0-1","RefSeq","NP_034308.1","25627895","The results of this study suggested for the first time that NSSR1 may provide a novel mechanism for reducing neuronal injury after ischemia, probably through regulation on alternative splicing of NCAM-L1 and CREB in astrocytes."
> "Q9R0U0-1","RefSeq","NP_034308.1","24710272","These results identify SRSF10 as an essential regulator for adipocyte differentiation."
> "Q9R0U0-1","RefSeq","NP_034308.1","24668663","We further show that an SRSRSK sequence in the RS3 domain may play an important role in the function of NSSR1 in pre-mRNA splicing. Publication Status: Online-Only"
20112,20116c27026,27031
< "Q8C6P8-1","RefSeq","NP_001013767.1","28476430","A group of functionally significant composite DNA elements (ZFP57 binding site (ZFBS)-Morph overlaps) that may play dual roles in the regulation of allele-specific gene expression."
< "Q8C6P8-1","RefSeq","NP_001013767.1","27257070","Another function of ZFP57 in early embryogenesis is to repress cis-acting regulatory elements whose activity is not yet required."
< "Q8C6P8-1","RefSeq","NP_001013767.1","26481358","Data show that ZFP57 binding is affected by single nucleotide polymorphism (SNPs) and closely associated TGCCGC motif sequences that are present at the target sites."
< "Q8C6P8-1","RefSeq","NP_001013767.1","26025256","Within established mouse imprinted clusters, ZFP57 specifically binds known or predicted imprinting control region elements, but does not interact with secondary somatically differentially methylated regions (DMRs) or germline DMRs that are not imprinting controlling. Publication Status: Online-Only"
< "Q8C6P8-1","RefSeq","NP_001013767.1","18854139","Zpf57 maintains both maternal and paternal genomic imprints."
---
> "Q9D7D2-1","RefSeq","NP_082273.1","19111575","Specific antisense oligonucleotides increase pulmonary infiltration of eosinophils in sensitized mice"
> "O35484-1","RefSeq","NP_061215.1","29677493","Upstream conserved coding region (uCC) length and the duration of the polyamine-induced pause on the PPW motif have been exquisitely matched to enable scanning ribosomes to efficiently skip over the uCC and translate the AZIN1 mORF under low polyamine conditions while enabling queuing and enhanced uCC translation when polyamine levels increase."
> "O35484-1","RefSeq","NP_061215.1","24077669","The polyamines regulate two novel steps of Azin1 expression, namely the transcription and a particular splicing pattern, both of which may affect the level of mRNA encoding the full-length active Azin1 protein."
> "O35484-1","RefSeq","NP_061215.1","23868013","MiR-433 is an important component of TGF-beta/Smad3-induced renal fibrosis through the induction of a positive feedback loop to amplify TGF-beta/Smad3 signaling."
> "O35484-1","RefSeq","NP_061215.1","19997757","The expression of AIn was increased during mammary gland development."
> "O35484-1","RefSeq","NP_061215.1","19077035","AZI plays an important role in regulating the levels of Ornithine decarboxylase, putrescine and spermidine in mice, and is essential for the survival of mice."
20126,20128c27041,27045
< "P55292-1","RefSeq","NP_001304294.1","30115995","These results demonstrate that Dsg2, but not desmocollin 2 is required for the integrity of the intestinal epithelial barrier in vivo"
< "P55292-1","RefSeq","NP_001304294.1","28339476","Cardiac specific overexpression of desmocollin-2 induces necrosis, acute inflammation and patchy cardiac fibrotic remodeling leading to fulminant biventricular cardiomyopathy. Publication Status: Online-Only"
< "P55292-1","RefSeq","NP_001304294.1","27834139","Downregulation of DSC2 is associated with arrhythmogenic cardiomyopathy."
---
> "Q8BRH0-1","RefSeq","NP_001103483.1","27773428","Our data suggest that loss of TMTC3 causes cobblestone lissencephaly with minimal eye or muscle involvement."
> "Q5SRY7-1","RefSeq","NP_598776.1","30391586","Investigated beta-TrCP function in Sertoli cells by generating mice with targeted deletion of the beta-TrCP2 gene in Sertoli cells on a background of whole-body beta-TrCP1 knockout. Loss of beta-TrCP in Sertoli cells caused infertility due to a reduction in the number of mature sperm."
> "Q5SRY7-1","RefSeq","NP_598776.1","30031111","Beta-TrCP was identified as a novel interacting partner of ASK1 that is capable of ubiquitinating and degrading ASK1 through the ubiquitin-proteasome system. These findings suggest that beta-TrCP is capable of suppressing oxidative stress-induced caspase 3-dependent apoptosis through suppression of ASK1."
> "Q5SRY7-1","RefSeq","NP_598776.1","26240281","The mTOR pathway promotes cell proliferation via beta-TrCP2-dependent p19(Arf) degradation under nutrient-rich conditions."
> "Q5SRY7-1","RefSeq","NP_598776.1","18782782","Data show that beta-TrCP2 and beta-TrCP1 target PER2 protein in vitro, and also show that the beta-TrCP binding site of PER2 is recognized by both beta-TrCP1 and beta-TrCP2 [beta-TrCP2]."
20135c27052,27056
< "A2APC3-1","RefSeq","NP_001077087.1","27257088","Ttll9 plays essential roles in maintaining the normal structure and beating pattern of sperm flagella by establishing normal heterogeneous polyglutamylation patterns."
---
> "A2A8U2-1","RefSeq","NP_808340.2","28893537","These observations suggest that tumor suppression was caused not by mtDNA with polymorphic mutations or infection of cytozoic bacteria but by hypothetical heritable cytoplasmic elements other than mtDNA from SAMP1 mice."
> "A2A8U2-1","RefSeq","NP_808340.2","28301579","Data demonstrate a heightened susceptibility to colonic inflammation and tumorigenesis in AOM/DSS-treated SAMP mice with CD-like ileitis Publication Status: Online-Only"
> "A2A8U2-1","RefSeq","NP_808340.2","25051721","In the SAMP1 mice versus the SAMR1 ones, the glial index rose by 36% in layer III and by 24% in layer V. During simulation of physiological aging, the sizes of neuronal bodies were shown to be virtually unchanged in the cerebral cortex"
> "A2A8U2-1","RefSeq","NP_808340.2","23583482","At 2- and 4-months old, SAMP1 mice show motor-coordination dysfunction."
> "A2A8U2-1","RefSeq","NP_808340.2","22349700","Findings show that the nuclear envelope protein Samp1 is involved in nuclear movement during fibroblast polarization and migration GeneRIF: Nuclear envelope protein Samp1 (NET5) is involved in nuclear movement during fibroblast polarization and migration. Samp1 is part of the TAN lines complex that contain nesprin-2G and SUN2. Samp1 associates with SUN2 and lamin A/C."
20139a27061,27067
> "P48545-1","RefSeq","NP_034735.3","29222092","Data show that potassium inwardly-rectifying channel subfamily J member 5 (Kcnj5) is important for baseline aldosterone secretion, but its importance is sex-limited at least in the mouse. Publication Status: Online-Only"
> "P48545-1","RefSeq","NP_034735.3","28464250","Histone H4 hyperacetylation induced by Class I HDACs inhibitors promoted the expression profiles of potassium channels (Kcnj2, Kcnj3, Kcnj5, Kcnj11, and Kcnh2)"
> "Q924W9-1","RefSeq","NP_476514.1","25522233","SCL-LMO1 upregulated a stem cell gene signature in DN3 thymocytes. Publication Status: Online-Only"
> "Q924W9-1","RefSeq","NP_476514.1","24122442","Loss of Lmo1 repression may be one of the causes accounting for the phenotypic differences identified between the Arx((GCG)7)and Arx(432-455dup24) mouse models."
> "Q9D883-1","RefSeq","NP_077149.2","27184077","The U2AF35(S34F) mutation alters interaction with CFIm59, leading to increased use of a distal cleavage and polyadenylation site in the ATG7 pre-mRNA, decreasing levels of ATG7 protein and defective autophagy, ultimately leading to transformation."
> "Q9D883-1","RefSeq","NP_077149.2","25965570","Findings support the hypothesis that mutant U2AF1 alters downstream gene isoform expression, thereby contributing to abnormal hematopoiesis in patients with MDS"
> "Q9D883-1","RefSeq","NP_077149.2","25706610","Data support the impact of genes from the Abcg1-U2af1 region as modifiers of Tc1-dependent memory and locomotor phenotypes in Tc1 mouse model of Down syndrome. Publication Status: Online-Only"
20148,20150c27076,27083
< "Q3TKT4-1","RefSeq","NP_001167550.1","30372823","The study highlights a potential role of Brg1 in regulating cerebral ischemia/reperfusion injury in vivo."
< "Q3TKT4-1","RefSeq","NP_001167550.1","30049497","BRG1 knockdown in the vascular endothelium suppressed neutrophil infiltration and down-regulated the levels of inflammation mediators in cardiac ischemia-reperfusion injury."
< "Q3TKT4-1","RefSeq","NP_001167550.1","30149919","An increase in Brg1 and a decrease in the PI3K/Akt/mTOR pathway activity were detected in asthmatic mice, but not in control mice. When Brg1 was knocked out, the asthma severity was ameliorated and the PI3K/Akt/mTOR pathway was activated."
---
> "Q9D1A2-1","RefSeq","NP_075638.2","30049418","This study shows that PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models"
> "Q9D1A2-1","RefSeq","NP_075638.2","26549037","These results provide evidence showing that intradimer interaction of H228 with the reaction center of the dimer counterpart is essential to the enzymatic activity of Cn2."
> "Q9D1A2-1","RefSeq","NP_075638.2","24631653","These findings suggest that the transduced PEP-1-PRX2 has neuroprotective functions against oxidative stress-induced cell death in vitro and in vivo"
> "Q9D1A2-1","RefSeq","NP_075638.2","18550540","Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2."
> "Q62351-1","RefSeq","NP_035768.1","31366551","Zfat knockdown partially inhibited CD71(-/low)Ter119(-) to CD71(high)Ter119(-) transition of fetal liver erythroid progenitors with impairment in the elevation of CD71 expression.  Zfat plays a critical role for erythropoiesis in the fetal liver."
> "Q62351-1","RefSeq","NP_035768.1","30538134","These data are consistent with an inhibitory function of Tfr1 on iron signaling to hepcidin via its interaction with Hfe."
> "Q62351-1","RefSeq","NP_035768.1","30093529","These studies describe how point mutations of the transferrin receptor can cause a microcytic anemia that does not respond to iron therapy and would not be detected by routine iron studies, such as serum ferritin."
> "Q91V83-1","RefSeq","NP_083558.1","24657168","IP7, formed by IP6K2, binds CK2 to enhance its phosphorylation of the Tti1/Tel2 complex, thereby stabilizing DNA-PKcs and ATM. This process stimulates p53 phosphorylation at serine 15 to activate the cell death program."
20154a27088
> "D3Z1D3-1","RefSeq","NP_001182026.1","28717008","Data suggest that Cefip (cardiac-enriched Fhl2-interacting protein) interacts with Fhl2 (four and a half LIM domains protein-2) and modulates calcineurin signaling in cardiomyocytes; Cefip is located at sarcomeric z-disc and is up-regulated in several models of cardiomegaly."
20181,20187c27115,27126
< "Q9Z188-1","RefSeq","NP_001033046.1","30317528","Through the activation of DYRK1B, Hedgehog signaling facilitates microtubule-dependent processes such as intracellular mitochondrial transport, mesenchymal cell polarization or directed cell migration."
< "Q9Z188-1","RefSeq","NP_001033046.1","29030970","We demonstrated that Anxa1, Anxa2, and Dyrk1b are upregulated at both the transcriptional and translational levels by the overexpression of GAS1"
< "Q9Z188-1","RefSeq","NP_001033046.1","24312406","Results suggest that functional interactions between BM88/Cend1, RanBPM and Dyrk1B affect the balance between cellular proliferation and differentiation in Neuro 2a cells Publication Status: Online-Only"
< "Q9Z188-1","RefSeq","NP_001033046.1","22711815","Cirp functions to fine-tune the proliferation of undifferentiated spermatogonia by interacting with Dyrk1b."
< "Q9Z188-1","RefSeq","NP_001033046.1","18818203","BCL2 and BCL-xL facilitation of G0 quiescence requires BAX, BAK, and p27 phosphorylation by Mirk"
< "Q9Z188-1","RefSeq","NP_001033046.1","12902328","Dyrk1B is a Rho-induced kinase active in skeletal muscle differentiation"
< "Q9Z188-1","RefSeq","NP_001033046.1","12384504","P38 MAP Kinase suppresses the function of Mirk as a transcriptional activator only when cells are proliferating"
---
> "Q61923-1","RefSeq","NP_038596.1","29139549","We are investigating the effects of hyperoxia on atrial electrophysiology using whole-cell patch-clamp electrophysiology experiments along with assessment of Kv1.5, Kv4.2, and KChIP2 transcripts and protein profiles using real-time quantitative RT-PCR and Western blotting."
> "Q9JLJ0-1","RefSeq","NP_064364.1","29953492","Results indicate that SIMPLE may regulate protein trafficking physiologically by localizing to the TGN and/or REs by binding PI4P. Publication Status: Online-Only"
> "Q9JLJ0-1","RefSeq","NP_064364.1","26573228","Suggest LITAF as regulatory of pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease."
> "Q9JLJ0-1","RefSeq","NP_064364.1","25963657","Data suggest that atypical inflammatory signaling kinetics may account for the gain of function elicited by the Litaf protein SIMPLE mutation in Charcot-Marie-Tooth Type 1C (CMT1C) patients."
> "Q9JLJ0-1","RefSeq","NP_064364.1","23576546","Mutation of SIMPLE (Litaf) in Charcot-Marie-Tooth 1C alters production of exosomes."
> "Q9QXP7-1","RefSeq","NP_064343.1","30030219","CTRP1 contributes to the regulation of blood pressure homeostasis by preventing dehydration-induced hypotension."
> "Q9QXP7-1","RefSeq","NP_064343.1","29964055","CTRP1 protected against Dox-induced cardiotoxicity via activation of AKT"
> "Q9QXP7-1","RefSeq","NP_064343.1","29733904","C1QTNF1 deficiency accelerates cardiac hypertrophy and fibrosis through decreasing AMPKa pathway."
> "Q9QXP7-1","RefSeq","NP_064343.1","28625919","By using en face staining of mouse aorta, the study found CTRP1 expression was significantly increased in vascular endothelial cells under disturbed flow as compared to steady laminar flow."
> "Q9QXP7-1","RefSeq","NP_064343.1","28131048","CTRP1 functions to prevent the development of pathological vascular remodeling by reducing vascular smooth muscle cell growth and neointima formation through cAMP-dependent pathway."
> "Q9QXP7-1","RefSeq","NP_064343.1","22086915","CTRP1 is a novel regulator of fatty acid metabolism."
> "Q99JR1-1","RefSeq","NP_081600.1","23590695","Connexin32 interacts with connexin26 and the mitochondrial protein, sideroflexin-1, at the plasma membrane forming a novel signaling nexus."
20188a27128,27133
> "Q8R1G1-1","RefSeq","NP_780434.1","30573454","Upon loss of taspase1, MLL1 association with chromatin is markedly increased due to the stabilization of its unprocessed version, and this stabilization of the uncleaved MLL1 can result in the displacement of MLL chimeras from chromatin in leukemic cells"
> "Q8R1G1-1","RefSeq","NP_780434.1","25664857","TFIIA is the principal TASP1 substrate that orchestrates craniofacial morphogenesis."
> "Q8R1G1-1","RefSeq","NP_780434.1","25267403","Taspase1 deficiency disrupts the expression of cyclins and proliferation of HER2+ breast cancer cells."
> "Q8R1G1-1","RefSeq","NP_780434.1","24176642","Taspase1 cleaves a ubiquitously expressed GTF (TFIIA) to enable tissue-specific (testis) transcription, meeting the demand for sophisticated regulation of distinct subsets of genes in higher organisms."
> "Q8R1G1-1","RefSeq","NP_780434.1","18395097","TASP1, EPS15R, and PRPF3 expression were significantly induced in HCCs of transgenic EGF2B mice as was P2 promoter-driven HNF4alpha"
> "Q8R1G1-1","RefSeq","NP_780434.1","16951254","This paper describes the quintessential function of Taspase1 in orchestrating cell cycle progression."
20192a27138,27139
> "O08609-1","RefSeq","NP_035680.3","26584623","MLX promotes myogenesis not via an adjustment of glucose metabolism but rather by inducing the expression of several myokines, including insulin-like growth factor 2 (IGF2)"
> "O08609-1","RefSeq","NP_035680.3","20385767","Glucose is required at two additional steps to stimulate the transcription activation function of MondoA-Mlx complexes."
20203a27151,27155
> "Q8BXQ6-1","RefSeq","NP_001276855.1","29275848","Our results characterize a novel aspect of miR-23b function in leukocyte migration, and they identify miR-23b as a potential therapeutic target in the amelioration of MS and likely other autoimmune diseases."
> "Q8BXQ6-1","RefSeq","NP_001276855.1","27755984","Decreased miRNA-27b regulates the activity of the CCL20/CCR6 axis by targeting Naa15, and promotes plaque stability in atherosclerosis"
> "Q8BXQ6-1","RefSeq","NP_001276855.1","26849429","MiRNA-27b regulates mitochondria biogenesis in myocytes by down-regulation of Foxj3 during myocyte differentiation. Publication Status: Online-Only"
> "Q8BXQ6-1","RefSeq","NP_001276855.1","25187367","These results indicate that miR-27b functions as a central target of glucocorticoids and as an upstream regulator of Prdm16."
> "Q8BXQ6-1","RefSeq","NP_001276855.1","17803194","Alternative splicing predictably produces protein products with or without the catalytic domain and/or a nucleolar localisation signal and represents mechanism in regulating activity of APO."
20208,20211d27159
< "Q9Z2X1-1","RefSeq","NP_001159899.1","29773655","FOXP3 represses the ability of hnRNPF to bind to its target pre-mRNA and thus modulates RNA alternative splicing"
< "Q9Z2X1-1","RefSeq","NP_001159899.1","28424160","HnRNP F protects kidneys against oxidative stress and nephropathy via stimulation of Sirtuin-1 expression and signaling in diabetes."
< "Q9Z2X1-1","RefSeq","NP_001159899.1","28324005","The beneficial actions of insulin in diabetic nephropathy appear to be mediated, in part, by suppressing renal Nrf2 and Agt gene transcription and preventing Nrf2 stimulation of Agt expression via hnRNP F/K."
< "Q9Z2X1-1","RefSeq","NP_001159899.1","26232095","These data demonstrate that hnRNP F stimulates Ace-2 gene transcription, prevents TGF-beta1 inhibition of Ace-2 gene transcription and induction of kidney injury in diabetes."
20219c27167
< "Q9R0N6-1","RefSeq","NP_001272790.1","11751263","Syt VIII is a candidate for the Ca(2+) sensor that regulates acrosomal exocytosis in mammalian sperm"
---
> "Q8BGE7-1","RefSeq","NP_001013637.1","22328504","TRIM6 regulates the transcriptional activity of Myc during the maintenance of cell pluripotency, suggesting that TRIM6 functions as a novel regulator for Myc-mediated transcription in embryonic stem cells."
20225a27174,27183
> "Q9JKK7-1","RefSeq","NP_057920.2","24746171","Role of Tmod2 protein's leucine rich repeat domain in the formation of neurite-like processes"
> "Q9JKK7-1","RefSeq","NP_057920.2","12799133","Tmod2 plays a role in behavior, learning, memory, and synaptic plasticity."
> "Q9D1F4-1","RefSeq","NP_080546.1","28294542","PRAS40 inhibits mTORC1 hyperactivation and plays a key role in protecting cells against neurotoxic prion peptide-induced apoptosis. Thus, PRAS40 is a potential therapeutic target for prion disease."
> "Q9D1F4-1","RefSeq","NP_080546.1","27349859","Overexpression of PRAS40(T246A) in the Proliferative Compartment Suppresses mTORC1 Signaling, Keratinocyte Migration, and Skin Tumor Development"
> "Q9D1F4-1","RefSeq","NP_080546.1","16397181","Overexpression of SOD1 may affect the PRAS pathway after transient focal cerebral ischemia by reducing the direct oxidative reaction to pPRAS after reperfusion injury"
> "Q9D1F4-1","RefSeq","NP_080546.1","14973226","PRAS phosphorylation and its interaction with pAkt and 14-3-3 might play an important role in neuroprotection mediated by NGF in apoptotic neuronal cell death after transient focal cerebral ischemia"
> "Q9D1F4-1","RefSeq","NP_080546.1","12524439","The protein product encoded by 1110012J22 gene is proline-rich substrate of Akt which also binds to 14-3-3.  A proposed name for this protein is thus PRAS40, for proline-rich substrate of Akt of 40 kDa."
> "P97290-1","RefSeq","NP_033906.2","22705194","C1INH prevented myocardial ischemia reperfusion injury in mice."
> "P97290-1","RefSeq","NP_033906.2","12421980","Transgenic mice have been generated that express human C1 inhibitor mRNA and protein under the control of the human promoter and regulatory elements; C1nh production is demonstrated in mouse brain, spleen, liver, heart, kidney, and lung."
> "P97290-1","RefSeq","NP_033906.2","11956243","Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor."
20237a27196,27202
> "Q9Z2V5-1","RefSeq","NP_034543.3","30999900","Biochemical analyses revealed an aberrant nuclear translocation of HDAC6 that leads to the hyper-acetylation of alpha-tubulin (an indication of over-stabilized microtubules) after hypoxic challenge was observed at different time points after stroke. Publication Status: Online-Only"
> "Q9Z2V5-1","RefSeq","NP_034543.3","30102568","On a high-fat diet, HDAC6-deficient mice were depleted in representatives of the S24-7 family and Lactobacillus but enriched with Bacteroides and Parabacteroides; these changes are associated with obesity"
> "Q9Z2V5-1","RefSeq","NP_034543.3","29890133","These findings suggested that HDAC6 contributes to mitochondrial thermogenesis in brown adipose tissue by increasing UCP1 expression through cAMP-PKA signaling pathway."
> "Q9Z2V5-1","RefSeq","NP_034543.3","29896294","HDAC6 plays a specific role in monocyte/macrophage recruitment. Loss of HDAC6 suppresses the phagocytic capacity of macrophages challenged with E. coli. The findings implicate HDAC6 in the innate immune response and suggest that it may serve as a promising target for the treatment of macrophage-associated immune diseases. Publication Status: Online-Only"
> "Q9Z2V5-1","RefSeq","NP_034543.3","29520015","Results link the aberrant GlyRS-HDAC6 interaction to Charcot-Marie-Tooth disease type 2D pathology and suggest HDAC6 as an effective therapeutic target. Publication Status: Online-Only"
> "Q02819-1","RefSeq","NP_032775.1","27178152","The chaperone protein Hsp70 was found to be important for CHIP and NUCB1 interaction as well as CHIP-mediated NUCB1 down-regulation."
> "Q02819-1","RefSeq","NP_032775.1","25038744","The expression and distribution of NUCB1 in tissues and cells of the mouse endocrine system, was examined."
20245a27211,27212
> "O70514-1","RefSeq","NP_032035.2","28864076","Study using Fgfbp1-knockout mice concludes that tissue-resident and circulating Fgfbp1-expressing cells modulate skin carcinogenesis and inflammation."
> "O70514-1","RefSeq","NP_032035.2","28053031","FGFBP1 expression decreases in skeletal muscles during aging and before neuromuscular junctions degeneration in SOD1(G93A) mice"
20246a27214,27217
> "Q9ER80-1","RefSeq","NP_075875.3","30348895","Selective MOPr-mediated increase in RTP4 expression."
> "Q9ER80-1","RefSeq","NP_075875.3","18836069","RTP4, a Golgi chaperone, is a regulator of the levels of heterodimers at the cell surface; association with RTP4 protects mu-delta receptors from ubiquitination and degradation"
> "Q9WTK5-1","RefSeq","NP_062281.1","29680659","In vivo bioluminescence imaging in a transgenic model of inflammation showed that luciferase activity coincided with endogenous p52/p100 Nfkb2 expression"
> "Q9WTK5-1","RefSeq","NP_062281.1","29666445","The study investigated the impact of non-canonical NF-kappaB signaling on lung carcinogenesis.  p52 over-expression led to increased tumor number and progression after injection of the carcinogen urethane in mice. Gene expression analysis of lungs from transgenic mice combined with in vitro studies suggested that p52 promotes proliferation of lung epithelial cells through regulation of cell cycle-associated genes. Publication Status: Online-Only"
20254a27226,27229
> "Q9CPV0-1","RefSeq","NP_082612.2","28954202","Multiple roles in craniofacial development"
> "Q9CPV0-1","RefSeq","NP_082612.2","26518474","TMEM107 Is a critical regulator of ciliary protein composition and is mutated in orofaciodigital syndrome mice."
> "Q9CPV0-1","RefSeq","NP_082612.2","26595381","TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome"
> "Q9CPV0-1","RefSeq","NP_082612.2","22698544","Data show that Transmembrane protein 107 (Tmem107) is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types."
20266a27242,27245
> "O54951-1","RefSeq","NP_038690.1","23646199","Class 6 transmembrane semaphorins are unlikely to serve as major PlexA receptor ligands for the assembly of murine retinal circuit laminar organization. Publication Status: Online-Only"
> "Q8BZ32-1","RefSeq","NP_766009.2","30093396","Findings indicate a critical role for additional sex combs-like protein 2 (ASXL2) in maintaining steady state hematopoiesis, and how its loss primes the expansion of myeloid cells."
> "Q8BZ32-1","RefSeq","NP_766009.2","28593990","ASXL2 functions as a tumour suppressor to maintain normal Hematopoietic stem cell function. Publication Status: Online-Only"
> "Q8BZ32-1","RefSeq","NP_766009.2","21490954","The knockdown of Asxl2 in bone marrow macrophages impaired their ability to form osteoclasts."
20275a27255,27258
> "Q9QYP6-1","RefSeq","NP_038755.1","23610142","AZI2 expression is critical for the generation of cDCs by GM-CSF and can potentially be used to increase the efficiency of immunization by cDCs."
> "Q99KF0-1","RefSeq","NP_570956.1","29689250","Hyperactivation of CARD14 alone is sufficient to orchestrate the complex immunopathogenesis that drives T helper type 17-mediated psoriasis skin disease in vivo."
> "Q99KF0-1","RefSeq","NP_570956.1","29980436","Caspase recruitment domain family member 14 (Card14)(E138A/+) and Card14(DeltaQ136/+) mice develop spontaneous psoriasis-like skin inflammation, resulted from constitutively activated CARMA2 via self-aggregation leading to the enhanced activation of the IL-23-IL-17A cytokine axis. Card14(-/-) mice display attenuated skin inflammation in the imiquimod-induced psoriasis model due to impaired IL-17A signaling in keratinoc..."
> "Q99KF0-1","RefSeq","NP_570956.1","29150564","In experimental models of psoriasis induced by either imiquimod cream or recombinant IL-23 injection, the psoriasiform skin inflammation was abrogated in Card14(-/-) mice"
20283a27267
> "Q3TVA9-1","RefSeq","NP_663549.3","27076447","Study demonstrates the essential role of CCDC136-mediated acrosome formation in spermatogenesis and fertilization, which might also provide new insight into the genetic causes of human infertility."
20294,20299d27277
< "Q8BG84-1","RefSeq","NP_001106945.1","30217615","Collagen degradation fragments inhibit osteoclast formation acting through LAIR-1, providing a novel mechanism for the physiologically-relevant negative control of osteoclastogenesis"
< "Q8BG84-1","RefSeq","NP_001106945.1","29884698","This study shows that LAIR1 inhibits Th1 Responses but Is required for natural and induced monocyte-dependent Th17 responses"
< "Q8BG84-1","RefSeq","NP_001106945.1","29269840","Absence of LAIR-1 in myocardial infarct mice does not influence infarct size, inflammation, fibrosis or adverse cardiac remodelling. Publication Status: Online-Only"
< "Q8BG84-1","RefSeq","NP_001106945.1","28887430","These data demonstrate that collagen can suppress the T cell cytokine response through the action of LAIR-1, and that LAIR-1-/- mice develop more severe arthritis"
< "Q8BG84-1","RefSeq","NP_001106945.1","28336561","LAIR-1 in megakaryocytes leads to increased Src family kinase activity and downstream signaling in response to collagen that is transmitted to platelets, rendering them hyper-reactive specifically to agonists that signal through Syk tyrosine kinases."
< "Q8BG84-1","RefSeq","NP_001106945.1","15100296","Mouse Lair-1 cytoplasmic tail can become phosphorylated, thereby recruiting SH2-containing tyrosine phosphatase-2 (SHP-2). Unlike human LAIR-1, SHP-1 is not recruited to the mouse Lair-1 cytoplasmic tail."
20301a27280,27282
> "O35405-1","RefSeq","NP_035246.1","30111894","This study shows that PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing"
> "O35405-1","RefSeq","NP_035246.1","22428023","PLD3 plays a role in myogenesis during myotube formation, potentially in the events surrounding ER reorganization."
> "O35405-1","RefSeq","NP_035246.1","19377048","Pld3 expression is associated with hematopoietic stem cells that have durable self-renewal potential."
20308a27290,27293
> "Q9Z2H6-1","RefSeq","NP_034949.3","28988116","MCL (macrophage C-type lectin) plays a crucial role in killing bacteria during Escherichia coli-induced peritonitis. MCL-deficient mice with E. coli-induced sepsis showed lower survival rates and reduced bacterial clearance when compared with control mice, despite similar levels of proinflammatory cytokine production."
> "Q9Z2H6-1","RefSeq","NP_034949.3","28107361","Dectin-3 deficiency did not lead to increased susceptibility of mice to experimental pulmonary C. neoformans infection. Also, no significant differences in pulmonary leukocyte recruitment and cytokine production were observed in Dectin-3 deficient mice compared to wild type infected mice Publication Status: Online-Only"
> "Q9Z2H6-1","RefSeq","NP_034949.3","27432944","Activation of CLRs Dectin-2 and Dectin-3 by fungi infections triggers them for ubiquitination and degradation in a Syk-dependent manner."
> "Q9Z2H6-1","RefSeq","NP_034949.3","11841491","The genomic organization of the MCL gene and the sequence of the promoter region were determined"
20316a27302
> "Q8R4U7-1","RefSeq","NP_077772.2","18801334","These findings assign a novel function of LUZP in the embryonic development of brain."
20329,20330d27314
< "Q61979-1","RefSeq","NP_035053.1","30279096","Nnat deletion was associated with postnatal growth restriction and adult obesity."
< "Q61979-1","RefSeq","NP_035053.1","23527188","Nnat expression in hypothalamus is regulated by short-term nutrient availability, but unaltered by diet-induced obesity or calorie restriction."
20340a27325
> "Q0P5V9-1","RefSeq","NP_001161727.1","25164149","MRNA expression of SLC45A2 in eyes and skin and of SLC45A3 primarily in the prostate, but also in other tissues, whereas SLC45A4 showed a predominantly ubiquitous expression"
20348,20351c27333,27339
< "O88839-1","RefSeq","NP_001032811.2","29939250","ADAM15 has a critical role in mediating vascular barrier dysfunction during inflammation. Its mechanisms of action involve CD44 shedding and endothelial glycocalyx injury."
< "O88839-1","RefSeq","NP_001032811.2","25650586","Findings indicated that silencing ADAM15 had antiinflammatory effects in FLSs and efficiently inhibited the development of CIA."
< "O88839-1","RefSeq","NP_001032811.2","25249606","The catalytic activity of ADAM15 is not crucial for its function in promoting pathological neovascularization in the mouse OIR model, most likely because of the very limited substrate repertoire of ADAM15. Publication Status: Online-Only"
< "O88839-1","RefSeq","NP_001032811.2","23161886","ADAM15 upregulation contributes to inflammatory lung injury by promoting endothelial hyperpermeability and neutrophil transmigration."
---
> "A2CG63-1","RefSeq","NP_937755.1","28207192","These results identified ARID4B as a master regulator of a signaling network that governs the establishment of a niche during the critical gonocyte-to-spermatogonial stem cells (SSC) transition phase to control the fate of gonocytes and SSCs."
> "A2CG63-1","RefSeq","NP_937755.1","26258622","The study identified ARID4B to be a key regulator of Sertoli cell function important for male germ cell development."
> "A2CG63-1","RefSeq","NP_937755.1","23487765","ARID4A and ARID4B function as transcriptional coactivators for AR and RB and play an integral part in the AR and RB regulatory pathways involved in the regulation of Sertoli cell function and male fertility."
> "A2CG63-1","RefSeq","NP_937755.1","18728284","10 of 12 Arid4a(-/-)Arid4b(+/-) mice progressed to acute myeloid leukemia (AML) and had rapid further increases of leukocyte counts."
> "P59900-1","RefSeq","NP_878260.1","27892605","Dispensable for hair follicle growth and maintenance"
> "P59900-1","RefSeq","NP_878260.1","22334695","Characterization of the expression and biochemical properties of EMILIN-3"
> "P59900-1","RefSeq","NP_878260.1","17660561","Transcripts highly enriched in ovary; gene identified as candidate female fertility factor."
20355a27344
> "Q3UTA8-1","RefSeq","NP_001257423.1","15289607","Described as a mouse-specific duplication of the MARK kinase family, and named MarkmC1."
20378a27368
> "Q9JI67-1","RefSeq","NP_149161.1","16112824","Case study of the endogenous retrovirus long terminal repeat promoter of this enzyme, beta1,3-galactosyltransferase 5"
20388a27379
> "P47911-1","RefSeq","NP_035420.2","14572897","Taxreb107 has a role as a lactogenic hormone-responsive gene during differentiation of the mammary gland."
20391a27383,27384
> "Q9EPV8-1","RefSeq","NP_079677.1","17026961","This report is the first to describe changes in the intracellular and subcellular localization of UBL5 in response to hypo-osmotic conditions."
> "Q9EPV8-1","RefSeq","NP_079677.1","12932856","Findings report of the presence and distribution of ubiquitin-like 5 in the mouse hypothalamus and pituitary"
20397a27391,27394
> "Q8VCF0-1","RefSeq","NP_659137.1","30878284","Apoptotic caspases control innate immunity and maintain immune homeostasis against viral infection, suppressing type I interferon production via the cleavage of cGAS, MAVS, and IRF3"
> "Q8VCF0-1","RefSeq","NP_659137.1","16785313","IPS-1 is the sole adapter in both retinoic acid-inducible gene (RIG-I) and melanoma differentiation-associated gene 5 (Mda5) signaling that mediates effective responses against a variety of RNA viruses."
> "Q8VCF0-1","RefSeq","NP_659137.1","16153868","Data suggest that VISA is critically involved in both virus-triggered TLR3-independent and TLR3-mediated antiviral interferon signaling."
> "Q8VCF0-1","RefSeq","NP_659137.1","16125763","The overexpression of mitochondrial antiviral signaling(MAVS)induces the expression of IFN-beta through activation of NF-kappaB and IRF 3, thus boosting antiviral immunity."
20402,20404d27398
< "Q8BUL6-1","RefSeq","NP_001333444.1","27859053","This study shows that TAPP1/2 double knock-out mice develop chronic germinal centers with age and show abnormal expression of B-cell activation anddevelop lupus-like characteristics including anti-DNA antibodies and deposition of immune complexes in kidneys"
< "Q8BUL6-1","RefSeq","NP_001333444.1","26242484","Results identify TAPP1 as an important negative regulator of oligodendrocyte precursor cells differentiation through the Mek/Erk signaling pathway."
< "Q8BUL6-1","RefSeq","NP_001333444.1","22777911","Interacts with phosphatidylinositol (3,4)-bisphosphate thus regulating B-cell activation and autoantibody production"
20422a27417
> "Q8VEM9-1","RefSeq","NP_082186.2","12606021","Cloned human and mouse Peas cDNAs (hPEAS/mPeas) and analyzed their tissue and stage-specific expressions; may be involved in meiotic recombination process"
20429a27425,27426
> "Q5DW34-1","RefSeq","NP_001103157.1","28992061","The euchromatic lysine methyltransferase GLP regulates heterochromatin organization and myogenic differentiation. Interestingly, GLP represses expression of the methyl-binding protein MeCP2 that induces heterochromatin clustering during differentiation."
> "Q5DW34-1","RefSeq","NP_001103157.1","16702210","Wiz plays a major role in G9a/GLP heterodimer formation in cultured stem cells."
20440a27438,27440
> "Q80ZI6-1","RefSeq","NP_955006.1","31037734","Downregulation of miR-431-5p promoted proliferation of enteric neural crest cells via targeting LRSAM1, which provides an innovative and candidate target for treatment of Hirschsprung's disease"
> "Q80ZI6-1","RefSeq","NP_955006.1","25692136","TLR4/NF-kappaB-responsive microRNAs and their potential target genes: a mouse model of skeletal muscle ischemia-reperfusion injury."
> "Q80ZI6-1","RefSeq","NP_955006.1","23519028","Lrsam1 mutant mice are more sensitive to challenge with acrylamide, a neurotoxic agent that causes axon degeneration, indicating that the axons in the mutant mice are indeed compromised."
20442a27443
> "P14234-1","RefSeq","NP_034338.3","27358479","The Hck, Fgr and Lyn kinases are also necessary for amastigote uptake by macrophages. Src-mediated Arg activation is required for efficient uptake."
20443a27445,27449
> "Q3V0K9-1","RefSeq","NP_001028382.1","27811163","PLS1 biases actin toward liquid packing, which allows stereocilia to grow to a greater diameter."
> "Q3V0K9-1","RefSeq","NP_001028382.1","27614263","We have identified a role for L-plastin in stabilizing long-lived podosomes and in enabling macrophage motility"
> "Q3V0K9-1","RefSeq","NP_001028382.1","25124451","Results show that plastin 1 is dispensable for the initial formation of stereocilia."
> "Q3V0K9-1","RefSeq","NP_001028382.1","24595139","This study identified LPL as being key to alveolar macrophage development and essential to an effective antipneumococcal response."
> "Q3V0K9-1","RefSeq","NP_001028382.1","19321664","Plastin 1 accumulates in the terminal web and interacts with keratin 19, possibly contributing to anchoring the rootlets to the keratin network."
20445,20448c27451,27457
< "P97797-1","RefSeq","NP_001277948.1","30929259","This study shows that miR-378a modulates macrophage phagocytosis and differentiation through targeting CD47-SIRPalpha axis in atherosclerosis"
< "P97797-1","RefSeq","NP_001277948.1","30770827","Data indicate that only signal regulatory protein alpha (SIRPalpha+) CD8(+) T cells actively proliferate and show cytolytic activity. Publication Status: Online-Only"
< "P97797-1","RefSeq","NP_001277948.1","30602457","Microglia are effector cells of CD47-SIRPalpha antiphagocytic axis disruption against glioblastoma."
< "P97797-1","RefSeq","NP_001277948.1","30308165","These results demonstrate that CD47-SIRPalpha signaling prevents excess microglial phagocytosis and show that molecular brakes can be regulated by activity to protect specific inputs"
---
> "Q8K448-1","RefSeq","NP_671752.2","20382126","ABCA5 influences macrophage cholesterol efflux, and selective disruption of ABCA5 in macrophages leads to increased atherosclerotic lesion development in female LDLr(-/-) mice."
> "Q8K448-1","RefSeq","NP_671752.2","15870284","ABCA5 is a protein related to a lysosomal disease and plays important roles, especially in cardiomyocytes and follicular cells Erratum:[Mol Cell Biol. 2005 Jul;25(13):5786]"
> "Q99LS3-1","RefSeq","NP_598661.1","21726982","Status of PSPH in normal skin epidermis and skin tumors along with its sub-cellular localization in epidermal keratinocytes and its requirement for squamous cell carcinoma proliferation"
> "Q99LS3-1","RefSeq","NP_598661.1","17495110","PSP has a role in neural stem cell proliferation and may regulate signaling between neural stem cells and other cells within the stem cell niche."
> "Q9JL96-1","RefSeq","NP_071721.2","16297992","Placental cathepsin M is alternatively spliced and exclusively expressed in the spongiotrophoblast layer"
> "Q9JL96-1","RefSeq","NP_071721.2","15514457","Possible association of cathepsins with placental lactogen-II may play important roles in placental functions during the latter half of pregnancy in mice."
> "Q9JL96-1","RefSeq","NP_071721.2","12054558","Shows evolution in placental expression by gene duplidatoin"
20452a27462,27466
> "Q8R054-1","RefSeq","NP_081114.2","29920554","We show that mice lacking SRPX2 show a specific reduction in excitatory VGlut2 synapses in the cerebral cortex, while VGlut1 and inhibitory synapses were largely unaffected. SRPX2 KO mice also exhibit an abnormal ultrasonic vocalization ontogenetic profile in neonatal pups, and reduced preference for social novelty. Publication Status: Online-Only"
> "Q3UUV5-1","RefSeq","NP_001171370.1","27181093","This study shows that Skap1-deficient (skap1-/-) mice are highly resistant to the induction of collagen-induced arthritis"
> "Q3UUV5-1","RefSeq","NP_001171370.1","26905930","SKAP1 can affect the function of talin in T-cells needed for optimal T-cell/dendritic cell conjugation"
> "Q3UUV5-1","RefSeq","NP_001171370.1","25851535","In this study, the authors identified that the ADAP-SKAP55 signaling module reduced CD8(+) cytotoxic T lymphocyte cytotoxicity and enhanced PD-1 expression in a Fyn-, Ca(2+)-, and NFATc1-dependent manner."
> "Q3UUV5-1","RefSeq","NP_001171370.1","17646386","Results identify a clear effector role for SKAP-55 in LFA-1 adhesion in peripheral T cells and demonstrate that dependency on SKAP-55 and ADAP differs among T cells and differs with the strength of the TCR signal."
20455a27470,27471
> "P97742-1","RefSeq","NP_038523.2","30635360","These data further implicate CPT-I flux as a key event influencing metabolic interactions during exercise, as a decline in l-carnitine sensitivity in addition to availability at higher power outputs could impair mitochondrial fatty acid oxidation. Publication Status: Online-Only"
> "P97742-1","RefSeq","NP_038523.2","30611282","Concurrent exercise improves insulin resistance and nonalcoholic fatty liver disease by upregulating PPAR-gamma, CPT-1A and Mcad activities. Publication Status: Online-Only"
20466a27483
> "Q8BGT7-1","RefSeq","NP_766017.1","28612854","The results show that SMNDC1 mRNA 5'-UTR forms an intramolecular, parallel G quadruplex structure comprised of three G quartet planes, which is bound specifically by FMRP both in vitro and in mouse brain lysates."
20473,20474d27489
< "Q9Z0L2-1","RefSeq","NP_001271120.1","28270618","HGF supports hindlimb motor neurons through c-Met; CNTF supports subsets of axial motor neurons through CNTFRalpha; and Artemin acts as the first survival factor for parasympathetic preganglionic motor neurons through GFRalpha3/Syndecan-3 activation."
< "Q9Z0L2-1","RefSeq","NP_001271120.1","25635057","RET coupling to ERK and Akt depends strongly on artemin concentration, and it is highest at the low (~100 pM) artemin levels required for neurite outgrowth."
20477a27493,27496
> "Q9WTX7-1","RefSeq","NP_067293.1","20488182","Results indicate that SPAG8 acts as a regulator of ACT and plays an important role in CREM-ACT-mediated gene transcription during spermatogenesis."
> "Q9WTX7-1","RefSeq","NP_067293.1","19930692","Fhl5 is not essential for testicular gene expression to a level detected by microarray-based measurements. Publication Status: Online-Only"
> "Q9WTX7-1","RefSeq","NP_067293.1","15247423","Results indicate that numerous postmeiotic genes under CREM (cAMP-responsive element modulator) control require the coactivator function of ACT (activator of CREM) in testis."
> "Q9WTX7-1","RefSeq","NP_067293.1","12493914","ACT selectively associates with KIF17b, a kinesin highly expressed in male germ cells; The ACT-KIF17b interaction is restricted to specific stages of spermatogenesis and directly determines the intracellular localization of ACT"
20487a27507,27508
> "Q61098-1","RefSeq","NP_032391.1","30093707","IL-1R signaling licenses effector cytokine production by memory CD4 T cells Publication Status: Online-Only"
> "Q61098-1","RefSeq","NP_032391.1","15323361","Review of structure, function and tissue distribution of IL-18R [review] Review article"
20493a27515
> "Q9Z223-2","RefSeq","NP_038854.2","27138983","Mocs2-deficient mice recapitulate the severe phenotype observed in humans and can now serve as a model for preclinical therapeutic approaches for MoCo deficiency type B."
20494a27517,27519
> "Q9DAJ2-1","RefSeq","NP_035699.2","29397043","Tnp1, Tekt1, and Plzf have essential roles in spermatogenesis and can be expressed during organ culture of testis; with this system, genes can be induced only at the molecular level and not beyond meiosis."
> "Q9DAJ2-1","RefSeq","NP_035699.2","24521320","These observations suggest another potential role for TEKT1 as a cytoskeletal element in the sperm head, or as a molecule involved in acrosome-related phenomena, such as acrosome reaction."
> "Q9DAJ2-1","RefSeq","NP_035699.2","17971504","Tekt1 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
20502a27528,27529
> "Q9CZM9-1","RefSeq","NP_082507.1","28292889","We conclude that colonic K(+) secretion is intact or even increased in mice lacking the beta2-subunit of KCa1.1 channel complex despite no additional compensatory induction of KCa1.1 beta-subunits."
> "Q9CZM9-1","RefSeq","NP_082507.1","25267913","Compared current properties and cell firing properties of wild type and knockout in slices and found that knockout abolished inactivation, slowed action potential repolarization, and, during constant current injection, decreased firing"
20512a27540,27551
> "Q18PE0-1","RefSeq","NP_001335407.1","28069867","The Dok-7's C-terminal region plays a key, but not fully essential, role in MuSK activation and NMJ formation."
> "Q18PE0-1","RefSeq","NP_001335407.1","27091576","These results demonstrate that correct, physiological levels of dok-7 expression are required for the postnatal maintenance of neuromuscular junctions."
> "Q18PE0-1","RefSeq","NP_001335407.1","26198629","Protein kinase CK2 interacts at the neuromuscular synapse with Rapsyn, Rac1, 14-3-3gamma, and Dok-7 proteins and phosphorylates the latter two."
> "Q18PE0-1","RefSeq","NP_001335407.1","18165682","The COOH-terminal NES and Src homology 2 target motifs play key roles in Dok-7/MuSK signaling for neuromuscular synaptogenesis."
> "Q18PE0-1","RefSeq","NP_001335407.1","16794080","Dok-7 is essential for neuromuscular synaptogenesis through its interaction with MuSK"
> "P07356-1","RefSeq","NP_031611.1","31160583","Progressive accumulation of Annexin A2 (AnxA2) in the myofiber matrix causes fibro/adipogenic precursors (FAP) differentiation into adipocytes.Lack of AnxA2 prevents FAP adipogenesis, protecting against adipogenic loss of dysferlinopathic muscle. Publication Status: Online-Only"
> "P07356-1","RefSeq","NP_031611.1","29030970","We demonstrated that Anxa1, Anxa2, and Dyrk1b are upregulated at both the transcriptional and translational levels by the overexpression of GAS1"
> "P07356-1","RefSeq","NP_031611.1","29217762","High ANXA2 expression is associated with Liver Tumorigenesis."
> "P07356-1","RefSeq","NP_031611.1","28857429","Tenascin-c promoted macrophage migration and VEGF expression through annexin II, the expression of which was modulated by HIF-1alpha."
> "P07356-1","RefSeq","NP_031611.1","28694388","Contributes to pulmonary microvascular integrity by enabling vascular endothelial cadherin-related phosphatase activity, thereby preventing vascular leak during alveolar hypoxia"
> "P10923-1","RefSeq","NP_033289.2","30639873","Particulate matter exposure increased the expression of osteopontin in the bronchial epithelium, serum, and bronchoalveolar lavage fluid of mice. Moreover, particulate matter induced osteopontin expression in human bronchial epithelial cells in a dose and time-dependent manner."
> "P10923-1","RefSeq","NP_033289.2","30808406","Study shows that osteopontin from muscle and non-muscle sources are equally important in the acute response of muscle to injury, and cannot substitute for each other, suggesting that they play distinct roles in regulation of cell behavior. Publication Status: Online-Only"
20518a27558
> "Q69Z26-1","RefSeq","NP_766592.2","27539848","Protein-tyrosine phosphatase receptor type G (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system"
20531d27570
< "Q8R242-1","RefSeq","NP_001280601.1","22465033","In di-N-acetylchitobiase-deficient mice Man2GlcNAc2 urine levels were up to 10-fold higher than in urine of wild-type animals."
20555,20561d27593
< "Q8R0I0-1","RefSeq","NP_001123985.1","30207087","Deletion of ACE2 induced the early manifestation of muscle weakness with signatures of muscle senescence. Angiotensin 1-7 improved muscle function in older mice, supporting future application of the peptide or its analogues in the treatment of muscle weakness in the elderly population."
< "Q8R0I0-1","RefSeq","NP_001123985.1","29679094","ACE2 is a novel factor required for exercise-dependent modulation of adult neurogenesis and essential for serotonin metabolism."
< "Q8R0I0-1","RefSeq","NP_001123985.1","29990483","High ACE2 expression is associated with acute lung injury."
< "Q8R0I0-1","RefSeq","NP_001123985.1","29884907","We show sex dimorphism in the severity of diabetes- and ANGII-related renal lesions, and demonstrate that ACE2- and ACE-related compensatory mechanisms are sex-specific. Supporting our previous findings, the modulation and ANGII-mediated crosstalk between ACE2 and ACE in diabetic nephropathy progression was more evident in males."
< "Q8R0I0-1","RefSeq","NP_001123985.1","15452268","Murine ACE2 less efficiently bound the S1 domain of SARS-CoV and supported less-efficient S protein-mediated infection."
< "Q8R0I0-1","RefSeq","NP_001123985.1","12487024","ACE2 gene is expressed mainly in the kidney and the lungs."
< "Q8R0I0-1","RefSeq","NP_001123985.1","12075344","Angiotensin-converting enzyme 2 is an essential regulator of heart function."
20562a27595,27596
> "A2AJL3-1","RefSeq","NP_083623.1","29220483","The strength of Fggy mRNA expression significantly correlated with increased whole body weight and gonadal fat weight of males but not females."
> "Q8BYK6-1","RefSeq","NP_766265.3","30591559","Findings uncover the role of YTHDF3 as a negative regulator of antiviral immunity through the translational promotion of FOXO3 mRNA under homeostatic conditions, adding insight into the networks of RNA-binding protein-RNA interactions in homeostatically maintaining host antiviral immune function and preventing inflammatory response."
20564a27599,27604
> "Q6P549-1","RefSeq","NP_034697.2","29749928","Here, the authors systematically investigated the bindings of each SAM domain of Eph receptors to the SAM domains from SHIP2 and Odin, and uncover a highly specific SAM-SAM interaction-mediated cytoplasmic Eph-effector binding pattern. Publication Status: Online-Only"
> "Q6P549-1","RefSeq","NP_034697.2","28830894","Data suggest that endothelial SHIP2 is required to maintain normal systemic glucose homeostasis and prevent oxidative stress-induced endothelial dysfunction."
> "Q6P549-1","RefSeq","NP_034697.2","28878342","The data suggest that inhibition of the catalytic activity of SHIP2 is beneficial in reducing oxidative stress, but leads to deleterious increase in apoptosis in podocytes with reduced expression of CD2AP. Publication Status: Online-Only"
> "Q6P549-1","RefSeq","NP_034697.2","28302370","Inactivation of SHIP2 leads to increased microvilli formation and solute reabsorption by the renal proximal tubule and was associated with hyperactivated ezrin/radixin/moesin proteins and increased Rho-GTP."
> "Q6P549-1","RefSeq","NP_034697.2","27834631","The authors concluded that the FcgammaRIIb-SHIP2 axis links Abeta neurotoxicity to tau pathology by dysregulating phosphoinositide metabolism, providing insight into therapeutic potential against Alzheimer's disease. Publication Status: Online-Only"
> "Q6P549-1","RefSeq","NP_034697.2","12145149","Association with the insulin resistance of diabetic db/db mice."
20569a27610
> "Q8C5H8-1","RefSeq","NP_001273184.1","23616928","MNADK is localized to mitochondria in Hep G2 cells, and a recombinant MNADK showed NAD kinase activity. MNADK is abundant in mitochondrion-rich tissues, such as liver. MNADK expression was suppressed in human liver tumors. Identification of MNADK immediately suggests a model in which NADK and MNADK are responsible for de novo synthesis of NADP(+) in cytosol and mitochondria, respectively. Publication Status: Online-Only"
20574a27616,27618
> "Q8BZN6-1","RefSeq","NP_780500.2","27502165","Dock10 negatively regulates membrane CD23 expression; negative regulation of CD23 expression by Dock10 could play a role in B cell maturation and function"
> "Q8BZN6-1","RefSeq","NP_780500.2","25851601","DOCK10 function in dendritic spine morphogenesis is mediated mainly by Cdc42 and its downstream effectors N-WASP and PAK3, although DOCK10 is also able to activate Rac1."
> "Q8BZN6-1","RefSeq","NP_780500.2","21514340","T cells and B cells exhibited inverse expression patterns of the DOCK10 isoforms"
20576,20579d27619
< "P97438-1","RefSeq","NP_001153322.1","30573346","These findings identify TREK1 as a potential molecular targets in migraine."
< "P97438-1","RefSeq","NP_001153322.1","30153110","These findings indicate a central role for cardiac fibroblast TREK-1 in the pathogenesis of pressure overload-induced cardiac dysfunction and serve as a conceptual basis for its inhibition as a potential therapy."
< "P97438-1","RefSeq","NP_001153322.1","28839101","Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins"
< "P97438-1","RefSeq","NP_001153322.1","29042297","Data demonstrate that inhibition of TWIK-related K(+) channel-1 (TREK-1) protects mice from cognitive impairment induced by anesthesia and TREK-1 is a potential therapeutic target against memory impairment induced by volatile anesthetics."
20588a27629
> "P61969-1","RefSeq","NP_034853.1","29769265","We provide genetic evidence that a transcription factor, Lmx1a, interacts with its negative regulator, Lmo4, to pattern various vestibular and auditory components of the mammalian inner ear."
20620a27662,27663
> "Q61144-1","RefSeq","NP_035313.2","30429473","Study uncovers a role of PS in presynaptic mechanisms, through APP cleavage and regulation of Syt7, that highlights aberrant synaptic vesicle processing as a possible new pathway in Alzheimer's disease. Publication Status: Online-Only"
> "Q61144-1","RefSeq","NP_035313.2","19573580","Egr-1 over-expression and down-regulation, as well as in-vivo examination of Egr-1 and Psen2 expression during fear conditioning, showed that Egr-1 does not regulate the Psen2 promoter."
20623,20628c27666,27667
< "Q69ZN7-1","RefSeq","NP_001093104.1","30333125","Data demonstrate myoferlin's critical role in lysosomal exocytosis by phagocytes"
< "Q69ZN7-1","RefSeq","NP_001093104.1","20571050","Increased expression in myofibres after muscle injury and in a mouse model of muscular dystrophy"
< "Q69ZN7-1","RefSeq","NP_001093104.1","20008164","IGF1 receptor recycling is required for normal myogenesis and myoferlin is a critical mediator of postnatal muscle growth mediated by IGF1"
< "Q69ZN7-1","RefSeq","NP_001093104.1","17702744","Myoferlin forms a complex with dynamin-2 and VEGFR-2, which prevents CBL-dependent VEGFR-2 polyubiquitination and proteasomal degradation."
< "Q69ZN7-1","RefSeq","NP_001093104.1","16280346","Myoferlin plays role in the maturation of myotubes and the formation of large myotubes that arise from the fusion of myoblasts to multinucleate myotubes."
< "Q69ZN7-1","RefSeq","NP_001093104.1","11959863","Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains. (myoferlin)"
---
> "Q99PV8-1","RefSeq","NP_067374.2","12717433","Bcl11b is a key regulator of both differentiation and survival during thymocyte development."
> "Q99PV8-1","RefSeq","NP_067374.2","12565905","These results indicate that loss-of-function mutations of Rit1 contribute to mouse lymphomagenesis and possibly to human cancer development."
20651,20652c27690,27691
< "P27546-1","RefSeq","NP_001192259.1","30327268","Data reveal for the first time that MAP4 drives pathological cardiac remodeling through its phosphorylation. These findings bear the therapeutic potential to ameliorate pathological cardiac remodeling by attenuating MAP4 phosphorylation."
< "P27546-1","RefSeq","NP_001192259.1","25898002","A novel isoform of MAP4 organizes the paraxial microtubule array required for muscle cell differentiation. Publication Status: Online-Only"
---
> "P56384-1","RefSeq","NP_778180.1","24085430","We obtained correlations between Atp5g3 and alcoholism- and obesity-relevant phenotypes. Publication Status: Online-Only"
> "Q8CII9-1","RefSeq","NP_057924.3","11841846","Expression pattern in antigen presenting cells"
20677a27717,27730
> "O08750-1","RefSeq","NP_059069.1","12023274","The GATA factors play an important role in transducing the survival signal of IL-3, and one of their cellular targets is E4bp4"
> "Q64GA5-1","RefSeq","NP_001161976.1","30161143","Validation of differentially expressed genes (DEGs) by quantitative RT-PCR showed a significant increase in PLA2 group 4c (Pla2g4c)/COX-2 (Ptgs2)/PGD2 synthase 2 (Hpgds) axis. PGD2 level in bronchoalveolar fluids of the OA-challenged mice was significantly increased. A 24-h incubation of BSM tissues with PGD2 caused a hyperresponsiveness to acetylcholine in naive control mice. Publication Status: Online-Only"
> "Q64GA5-1","RefSeq","NP_001161976.1","22082005","Results link cytokine-mediated alterations in cPLA2gamma gene expression with allergic asthma and outline a complex regulatory mechanism"
> "Q64GA5-1","RefSeq","NP_001161976.1","20817734","Genetic ablation of calcium-independent phospholipase A2gamma prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation."
> "Q64GA5-1","RefSeq","NP_001161976.1","20452986","CPLA(2) has a role in the induction of cell autonomous cellular immunity to Chlamydia"
> "Q64GA5-1","RefSeq","NP_001161976.1","17213206","IPLA2gamma has roles in the lipid plasticity of myocardium, in generating signaling metabolites, and in modulating energy storage and utilization in myocardium in different metabolic contexts"
> "Q9CR73-1","RefSeq","NP_080659.1","17971453","Study provides evidence that PNRC2 plays one or more important roles in controlling the energy balance between energy storage and energy expenditure. PNRC2 may be a new target in the treatment of obesity and related metabolic diseases."
> "Q9CR73-1","RefSeq","NP_080659.1","16181749","The finding that the PNRC2 promoter is activated by NFY and repressed by E2F1 indicates that in addition to functioning as nuclear receptor coactivator, PNRC2 may also play a role in the cell cycle."
> "Q8K3J5-1","RefSeq","NP_082521.1","29750959","ZNF131 suppresses expression of Cdk inhibitor, p21(cip1), and that of pro-apoptotic factors, Bax and Puma, targets of p53, to facilitate cell cycle progression and suppress unnecessary apoptosis, respectively, of pro-B cells."
> "Q8K3J5-1","RefSeq","NP_082521.1","28882591","We also demonstrate that Kaiso inhibits Znf131 expression, raising the possibility that Kaiso and Znf131 act to fine-tune target gene expression. Together, our findings implicate Znf131 as a co-regulator of Kaiso-mediated biological processes."
> "Q8K3J5-1","RefSeq","NP_082521.1","26136427","Znf131 is critical for T cell development during double-negative to double-positive stage, with which significant cell expansion triggered by the pre-TCR signal is coupled."
> "Q8K3J5-1","RefSeq","NP_082521.1","20303951","Znf131 is a transcriptional activator, a less common function of POZ-ZF proteins, that is negatively regulated by its heterodimerization partner Kaiso."
> "Q8K3J5-1","RefSeq","NP_082521.1","17306895","The mechanism of Znf131 nuclear localization, is reported."
> "Q8K3J5-1","RefSeq","NP_082521.1","12163020","Results suggest that Znf131/ZNF131 plays a role during development and organogenesis as well as in the function of the adult central nervous system."
20689a27743,27746
> "Q64702-1","RefSeq","NP_775261.2","28972102","Aurora A and Plk4 are rate-limiting factors contributing to microtubule growth as the acentriolar oocyte resumes meiosis."
> "Q64702-1","RefSeq","NP_775261.2","26595384","That aneuploidy induced by transient centrosome amplification can accelerate tumorigenesis in p53-deficient cells"
> "Q64702-1","RefSeq","NP_775261.2","26439168","Transient knockdown of KLF14 is sufficient to induce Plk4-directed centrosome amplification. Publication Status: Online-Only"
> "Q64702-1","RefSeq","NP_775261.2","12352953","2.0 A crystal structure of a novel domain composed of the polo box motif of murine Sak"
20706,20709d27762
< "Q91WT8-1","RefSeq","NP_001120854.1","30309881","A1CF and RBM47 each function independently, yet interact in a tissue-specific manner, to regulate the activity and site selection of APOBEC1 dependent C-to-U RNA editing."
< "Q91WT8-1","RefSeq","NP_001120854.1","26789794","Study demonstrated that Rbm47 function is required in the embryo proper, and not the visceral endoderm, for viability and growth."
< "Q91WT8-1","RefSeq","NP_001120854.1","24916387","RBM47 and APOBEC1 constitute the basic machinery for C to U RNA editing."
< "Q91WT8-1","RefSeq","NP_001120854.1","23649762","RNA-binding protein Rbm47 binds to Nanog in mouse embryonic stem cells."
20728a27782,27788
> "Q921Z5-1","RefSeq","NP_598892.2","29620232","Study revealed that TIPE overexpression obviously augmented the volume and weight of the tumors, indicating that TIPE facilitates tumor formation probably through its antiapoptotic effect on JNK and p38 activation."
> "Q921Z5-1","RefSeq","NP_598892.2","29488604","TNFAIP8 expression following CLP may be associated with the pathogenesis of immune dysfunction in splenic T lymphocytes in mice."
> "Q921Z5-1","RefSeq","NP_598892.2","27655497","CD4+ T lymphocyte proliferative activity was significantly down-regulated when TNFAIP8 gene was silenced by siRNA in mice at 24 h post burn. Down-regulation of TNFAIP8 can significantly decrease expression levels of IL-2 and soluble IL-2R at 24 h after thermal injury."
> "Q921Z5-1","RefSeq","NP_598892.2","25948814","TIPE plays an important role in maintaining colon homeostasis and in protecting against colitis."
> "Q921Z5-1","RefSeq","NP_598892.2","25948813","TNFAIP8 regulates RAC1 signaling during TNF-alphaR activation and L. monocytogenes invasion of cells and that this regulation is crucial for controlling cell death and lethal L. mono-cytogenes infection of mice."
> "Q921Z5-1","RefSeq","NP_598892.2","20607800","Data suggest that Galphai-TNFAIP8-mediated rescue of pre-oncogenic cells enhances progression to oncogenic transformation, providing a selective target to inhibit cellular transformation."
> "Q921Z5-1","RefSeq","NP_598892.2","19730441","Tnfaip8 is crucial in regulating glucocorticoid-mediated apoptosis of thymocytes"
20732,20734c27792,27793
< "Q71M36-1","RefSeq","NP_001159745.1","24265546","Despite the previously reported upregulation of Cspg5 during retinal degeneration in Rpe65/ mice, no protective effect or any involvement of Cspg5 in disease progression was identified. Publication Status: Online-Only"
< "Q71M36-1","RefSeq","NP_001159745.1","23889129","CALEB is transiently required for synapse maturation in the cerebellum."
< "Q71M36-1","RefSeq","NP_001159745.1","11929867","Phosphorylation and localization in lipid rafts"
---
> "A2A9T0-1","RefSeq","NP_932768.2","30022064","SINTBAD regulates IL-15-induced autophagy and NKT cell survival. Publication Status: Online-Only"
> "A2A9T0-1","RefSeq","NP_932768.2","17568778","Results suggest that efficient signal transduction upon viral infection requires SINTBAD, TANK and NAP1 because they link TBK1 and IKKi to virus-activated signalling cascades"
20741a27801
> "P24610-1","RefSeq","NP_032807.3","31127120","Study identifies Pax3 interaction with members of the chromatin looping complex, including the LIM-domain binding protein 1 (Ldb1) and demonstrates that Ldb1 is recruited to a subset of Pax3-bound elements characterized by increased levels of H3K4me1 deposition. Reduced Ldb1 expression impairs Pax3-dependent myogenic specification both in vitro and in vivo. Publication Status: Online-Only"
20746a27807,27809
> "Q9WTJ4-1","RefSeq","NP_035943.3","20360400","FLT3 and CD43 signaling pathways involve STAT5A via Fiz1 and Hipk2 in B lymphoblastic lymphomas."
> "Q9WTJ4-1","RefSeq","NP_035943.3","18854042","Fiz1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo. Publication Status: Online-Only"
> "Q9WTJ4-1","RefSeq","NP_035943.3","15304385","Addition of potent FLT3 inhibitors such as SU11248 to acute myeloid leukemia chemotherapy regimens could result in improved treatment results."
20755a27819
> "Q3TY86-1","RefSeq","NP_780387.2","19280713","AIF-deficient mice display similar rates of H2O2 release and protein carbonyl modifications in brain mitochondria compared to WT controls"
20757a27822,27823
> "Q9D304-1","RefSeq","NP_075759.3","30571701","Grail contributes to the attenuation of hyperinflammation caused by activated macrophages and prevents organ damage in endotoxemic mice. Publication Status: Online-Only"
> "Q9D304-1","RefSeq","NP_075759.3","28798332","Loss of Grail enhances anti-tumour reactivity and functionality of CD8(+) T cells. Publication Status: Online-Only"
20770d27835
< "Q6P3A8-1","RefSeq","NP_001292864.1","16875466","Disruption of the BDK gene establishes that regulation of BCKDH by phosphorylation is critically important for the regulation of oxidative disposal of branched-chain amino acids."
20772a27838,27842
> "Q4PZA2-1","RefSeq","NP_955011.1","29524599","Expression of ECE1 suppressed dopamine neuron loss and alleviated the corresponding motor deficits."
> "Q4PZA2-1","RefSeq","NP_955011.1","27644077","It is a amyloid beta degrading enzyme and is expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex."
> "Q60773-1","RefSeq","NP_034008.2","28074012","The expression of three tumor suppressor genes encoded in the INK4/ARF locus (p15(INK4b), p16(INK4a), and p19(ARF)) was decreased in E6AP(-/-) embryo fibroblasts. Publication Status: Online-Only"
> "Q60773-1","RefSeq","NP_034008.2","27664376","TWIST1-E protein heterodimeric complexes may thus constitute the main active forms of TWIST1 with regard to senescence inhibition over the time course of breast tumorigenesis."
> "Q60773-1","RefSeq","NP_034008.2","26962681","Rescue from early-onset hearing loss in a mouse model lacking the cyclin-dependent kinase inhibitor p19Ink4d. Publication Status: Online-Only"
20773a27844,27846
> "Q80W22-1","RefSeq","NP_848500.3","17034760","In vitro, the protein encoded by BC051244 acts as a phospho-lyase on large, phosphorylated amino acids. For example, it degrades O-phospho-threonine to ketobutyrate, phosphate, and ammonia."
> "A3KGA4-1","RefSeq","NP_001120641.1","20307260","The studies support the hypothesis that MRFs transactivate Tceal7 gene expression and promote muscle differentiation during muscle development and regeneration. Publication Status: Online-Only"
> "A3KGA4-1","RefSeq","NP_001120641.1","15870691","These data implicate human TCEAL7 as a cell death regulatory protein that is frequently inactivated in ovarian cancers, and suggest that it may function as a tumor suppressor."
20784,20786d27856
< "Q9WV69-1","RefSeq","NP_001239591.1","27073223","Results demonstrate that dematin plays a critical role in maintaining the fundamental properties of the membrane cytoskeleton complex."
< "Q9WV69-1","RefSeq","NP_001239591.1","23060452","The headpiece domain of dematin regulates calcium mobilization and signaling in platelets"
< "Q9WV69-1","RefSeq","NP_001239591.1","21084299","Remodeling of the host cell directed Plasmodium includes the recruitment of dematin, an actin-binding protein of the erythrocyte membrane skeleton and its repositioning to the parasite"
20788a27859
> "Q811W2-1","RefSeq","NP_780684.1","11744378","Differential expression of the retinoic acid-metabolizing enzymes CYP26A1 and CYP26B1 during murine organogenesis."
20806a27878,27880
> "P06796-1","RefSeq","NP_031812.2","23613978","The Csn3 expression is upregulated via all-trans retinoic acid-bound RARalpha. Publication Status: Online-Only"
> "P06796-1","RefSeq","NP_031812.2","21991377","CSN3 and CSN5 are involved in oocyte meiosis by regulating degradation of Cyclin B1 and Securin via APC/C."
> "P06796-1","RefSeq","NP_031812.2","16698927","Kappa-casein has a role in mouse lactation"
20840a27915
> "Q9QUS6-1","RefSeq","NP_035975.1","25924778","Both MID1 and MID2 play a central role in the regulation of granule exocytosis and that functional redundancy exists between MID1 and MID2 in cytotoxic T cells"
20842a27918,27924
> "P35383-1","RefSeq","NP_032799.2","30236554","P2Y2 receptor expression was mechanistically upregulated by TNF-alpha mainly through extracellular regulated protein kinase (ERK) and c-Jun N-terminal kinase (JNK) signaling pathways."
> "P35383-1","RefSeq","NP_032799.2","30338362","Interfering with somatic P2Y2 signalling prevents excessive immune cell deposition in diet-induced obesity (DIO), both attenuating adipose tissue inflammation and ameliorating the metabolic phenotype. Publication Status: Online-Only"
> "P35383-1","RefSeq","NP_032799.2","29297959","The results of this study suggest that P2Y2Rs contribute to the development of salivary gland inflammation in IL-14alphaTG mice and may also contribute to autoimmune sialadenitis in humans."
> "P35383-1","RefSeq","NP_032799.2","29401585","Results suggest that LPS induces unbalanced proteostasis in astrocytes by blocking P2Y2R. Finally, our findings point to the design of selective P2Y2R agonist drugs as a new therapeutic approach to treat the neuroinflammatory status."
> "Q9D0M5-1","RefSeq","NP_080832.1","22328512","GKAP-DLC2 interaction organizes the postsynaptic scaffold complex to enhance synaptic NMDA receptor activity."
> "Q9D0M5-1","RefSeq","NP_080832.1","20208559","DLC2-mutant mice display enhanced angiogenic responses."
> "Q9D0M5-1","RefSeq","NP_080832.1","16981716","These data show that alternative splicing of the myosin Va heavy chain controls DYNLL2-myosin Va interaction and that DYNLL2 binding alters the structure of a portion of the myosin's coiled-coil domain."
20853a27936,27937
> "P05017-1","RefSeq","NP_034642.2","30915127","In osteocytes (but not osteoblasts), miR-29b-3p was responsive to the mechanical tensile strain and regulated osteoblast differentiation via regulating IGF-1 secretion of mechanically strained osteocytes. Publication Status: Online-Only"
> "P05017-1","RefSeq","NP_034642.2","30808767","Hese data identify that dopamine neuron-derived IGF-1 acts as a regulator of dopamine neurons and regulates dopamine-mediated behaviors."
20855,20858d27938
< "P70451-1","RefSeq","NP_001033086.2","27401557","Levels of FER were elevated in ovarian cancer cell lines relative to those in immortalized normal surface epithelial cells and that suppression of FER attenuated the motility and invasive properties of these cancer cells"
< "P70451-1","RefSeq","NP_001033086.2","27226326","Sperm from mice targeted with a kinase-inactivating mutation in Fer failed to undergo capacitation-associated increases in tyrosine phosphorylation."
< "P70451-1","RefSeq","NP_001033086.2","25237066","Directed mitochondrial accumulation of FerT endowed nonmalignant cells with tumor-forming ability"
< "P70451-1","RefSeq","NP_001033086.2","23589302","A critical role of Fer in PDGF-BB-induced STAT3 activation and cell transformation."
20860a27941
> "Q9D8X5-1","RefSeq","NP_081225.1","27605379","Study reports that a complex of BTG4 and CAF1 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs"
20884c27965
< "Q60936-1","RefSeq","NP_001156762.1","27499294","Loss of COQ8a results in cerebellar ataxia and coenzyme Q deficiency."
---
> "Q9DBJ6-1","RefSeq","NP_083068.1","23625928","JosD1, a membrane-associated DUB whose activity is regulated by ubiquitination, helps regulate membrane dynamics, cell motility, and endocytosis."
20915a27997
> "Q8K214-1","RefSeq","NP_038911.1","23207902","Loss of Scmh1 caused derepression of Hoxb4 and Hoxa9, direct targets of Polycomb-group complex 1-mediated transcriptional silencing in hematopoietic cells."
20916a27999,28003
> "Q99KU0-1","RefSeq","NP_083754.2","29359349","These results indicate that miR-21a negatively modulates two tumor suppressor genes, miR-200c and PTEN, thereby promoting M2 macrophage transformation"
> "Q99KU0-1","RefSeq","NP_083754.2","28890335","VMP1 modulates SERCA2 activity to control endoplasmic reticulum contacts for autophagosome formation."
> "Q99KU0-1","RefSeq","NP_083754.2","27415425","It has been concluded that VMP1-mediated autophagy cooperated with Kras to promote pancreatic ductal adenocarcinoma initiation. Publication Status: Online-Only"
> "Q99KU0-1","RefSeq","NP_083754.2","22535956","AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells."
> "Q99KU0-1","RefSeq","NP_083754.2","21173155","Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death."
20921a28009
> "F8VPU2-1","RefSeq","NP_598843.3","23209303","It was shown that Farp1 regulates dendritic filopodial dynamics in immature neurons. Later in development, Farp1 is postsynaptic and FARP1's 4.1 protein/ezrin/radixin/moesin domain binds SynCAM 1, assembling a synaptic complex."
20933a28022,28027
> "Q9WTL8-1","RefSeq","NP_031515.1","31042800","Our studies highlight that IRS-1, by regulating BMAL1, is an important regulator of Kir4.1 in Muller cells and the dysfunctional signaling mediated by IRS-1 may be detrimental to Kir4.1."
> "Q9WTL8-1","RefSeq","NP_031515.1","30804225","Much of BMAL1 target gene transcription depends on BMAL1 capacity to rhythmically regulate a network of enhancers."
> "P97792-1","RefSeq","NP_034118.1","31083261","In this study, a CEACAM-1 overexpression vector was constructed, and the effects of CC1 overexpression post CVB3 infection were analyzed. The results suggested that CC1 may promote CAR expression in cardiomyocytes after CVB3 infection, and CAR may be a potential target for CC1 to regulate the CVB3-induced process of myocardial injury. CC1 might regulate CAR expression by activating the CC1-SYK- TNF-[alpha] signaling axis."
> "P97792-1","RefSeq","NP_034118.1","28381574","Coxsackievirus and Adenovirus Receptor and potentially an unidentified factor present in mouse serum might be important mediators of Human adenoviral serotype 5 transduction. Publication Status: Online-Only"
> "P97792-1","RefSeq","NP_034118.1","21674029","CAR exerts important functions in the physiology of several organs in vivo"
> "P97792-1","RefSeq","NP_034118.1","12823902","The mCAR gene is situated on the distal portion of murine chromosome 16, and is composed of at least eight exons, with intron-exon boundaries similar to those reported for the human CAR gene"
20938a28033
> "Q6PG16-1","RefSeq","NP_941054.2","26149421","Study showed major differences in gene copy number in natural populations. CWC22, SFI1, and HJURP are highly conserved genes with the most copy-number variation. They all exhibit population-specific expansion patterns, perhaps for local adaptations."
20943a28039
> "Q5DTW7-1","RefSeq","NP_080330.1","29728365","We characterized two factors, MORC2A and RESF1, of which RESF1 is a novel molecule in retroelement silencing. Although both factors are recruited to repress provirus, their roles in repression are different. MORC2A appears to function dependent on repressive epigenetic modifications, while RESF1 regulates repressive epigenetic modifications associated with SETDB1"
20965a28062,28063
> "Q80V23-1","RefSeq","NP_808352.1","25032857","The overexpression of Zfp637 markedly increases mTERT expression and telomerase activity, maintains telomere length, and inhibits H2O2 and D-galactose-induced senescence. Publication Status: Online-Only"
> "Q80V23-1","RefSeq","NP_808352.1","20235149","Results suggest that Zfp637 inhibits muscle differentiation through a defect in the cell cycle exit by potentially regulating mTERT expression in C2C12 myoblasts"
20978a28077,28081
> "Q811P8-1","RefSeq","NP_796353.3","30045817","Our results suggest that PX-RICS-mediated GABAAR trafficking is a key target for GABAergic plasticity and its dysfunction leads to atypical emotional processing underlying autism."
> "Q811P8-1","RefSeq","NP_796353.3","17663722","These results suggest that PX-RICS is involved in early brain development including extension of axons and dendrites, and postnatal remodeling and fine-tuning of neural circuits."
> "Q811P8-1","RefSeq","NP_796353.3","17272280","P200 RhoGAP can mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation"
> "Q811P8-1","RefSeq","NP_796353.3","16716191","RICS plays an important role in neurite extension"
> "Q811P8-1","RefSeq","NP_796353.3","12531901","RICS may regulate dendritic spine morphology and strength by modulating Rho GTPases [RICS]"
20985a28089,28090
> "E9PY61-1","RefSeq","NP_001074689.1","26396487","A no b-wave (nob) electroretinography phenotype arose spontaneously in a colony of C3H mice and was named nob5. A mutation was identified in the Gpr179 gene in homozygous nob5 mice. Publication Status: Online-Only"
> "E9PY61-1","RefSeq","NP_001074689.1","22689652","The loss of GPR179 in a mouse model of night blindness prevented targeting of RGS to the postsynaptic compartment of bipolar neurons in the retina, illuminating the role of GPR179 in night vision."
20987,20991c28092,28096
< "Q8R1R4-1","RefSeq","NP_001128572.1","30573681","These results indicated a novel GRP78-dependent localization and specific function of IL-34 in FL-Y cells related to monocytic cell differentiation."
< "Q8R1R4-1","RefSeq","NP_001128572.1","29664689","The IL-34 acts as a proinflammatory factor, aggravating the severity of arthritis in CIA mice by inducing the production of IL-17."
< "Q8R1R4-1","RefSeq","NP_001128572.1","27865758","The current study aimed to assess the IL-34 expression in response to two members of the transforming growth factor (TGF)-beta family, TGF-beta1 and bone morphogenetic protein (BMP)-2, in synovial fibroblasts from rheumatoid arthritis patients."
< "Q8R1R4-1","RefSeq","NP_001128572.1","21494622","This study was to explore the biological function, specifically osteoclastogenesis and bone metabolism, of il-34. Publication Status: Online-Only"
< "Q8R1R4-1","RefSeq","NP_001128572.1","20504948","The different spatiotemporal expression of IL-34 and CSF-1 allows for complementary activation of the CSF-1R in developing and adult tissues."
---
> "P18894-1","RefSeq","NP_034148.2","30938755","Age- and gender-dependent D-amino acid oxidase activity in mouse brain and peripheral tissues: implication for aging and neurodegeneration"
> "P18894-1","RefSeq","NP_034148.2","29532193","This work provides the most complete baseline analysis of L- and D-amino acids in the brains of wild-type and mutant mice lacking D-amino acid oxidase activity."
> "P18894-1","RefSeq","NP_034148.2","29194436","Some significant in vivo effects of DAOR199W on motor neuron function (i.e. kyphosis and loss of motor neurons) were detected which were most marked in females and could contribute to the earlier onset of neurological signs in double transgenic females compared to SOD1G93A littermates, highlighting the importance of recognizing gender effects present in animal models of ALS Publication Status: Online-Only"
> "P18894-1","RefSeq","NP_034148.2","27670111","Findings reveal that DAO is a microbiota-regulated host innate immune factor that modulates growth of both pathogens and commensals, primarily in the small intestine Publication Status: Online-Only"
> "P18894-1","RefSeq","NP_034148.2","26833794","Long-term spatial memory is unaltered in Dao-/- mice."
21001,21002c28106
< "P17047-1","RefSeq","NP_001017959.1","30048497","Interruption of LAMP-2 expression did not result in an increase of the steady-state protein levels of DJ-1 /PARK7, as it would have been expected. No change in DJ-1 /PARK7 protein levels were observed upon inhibition of lysosomal function with NH4Cl or NH4Cl plus leupeptin, or after activation of CMA by serum starvation for 24h. Publication Status: Online-Only"
< "P17047-1","RefSeq","NP_001017959.1","30068868","Both LAMP-1 and LAMP-2 are involved in C2C12 myotube formation and LAMP-2 may contribute dominantly to it."
---
> "O35125-1","RefSeq","NP_001289484.1","17971504","Lrrc23 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
21010,21015d28113
< "Q9R007-3","RefSeq","NP_001033693.1","29126450","MDL-1 is mainly expressed in atherosclerotic lesional macrophages and increased macrophage MDL-1 expression is associated with early plaque progression and promotes macrophage survival. Publication Status: Online-Only"
< "Q9R007-3","RefSeq","NP_001033693.1","28824166","Data show that C-type lectin member 5A (CLEC5A) is needed for optimal reactive oxygen species (ROS) production, neutrophil extracellular traps (NETs) formation and other immune responses to Listeria monocytogenes in mice. Publication Status: Online-Only"
< "Q9R007-3","RefSeq","NP_001033693.1","27795434","The results suggest that CLEC5A-mediated enhancement of the inflammatory response in myeloid cells contributes to influenza pathogenicity in vivo and may be considered a therapeutic target in combination with effective antivirals. Publication Status: Online-Only"
< "Q9R007-3","RefSeq","NP_001033693.1","27033255","CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis"
< "Q9R007-3","RefSeq","NP_001033693.1","26927798","Cigarette smoke-induced macrophage responsiveness is mediated by CLEC5A, and CLEC5A is required for the development of inflammation, proinflammatory cytokine expression, and airspace enlargement."
< "Q9R007-3","RefSeq","NP_001033693.1","19074552","MDL-1 plays an important role in immune defense as a result of an innate immunity, which involves neutrophils and macrophages"
21018a28117,28119
> "Q9WU00-1","RefSeq","NP_035068.3","30333037","That Nrf1 and Nrf1-mediated pathways have context-dependent and cell-state-specific functions during neural development Publication Status: Online-Only"
> "Q9WU00-1","RefSeq","NP_035068.3","30261697","MRNA and protein levels of Nrf1D were detected to varying extents in hemopoietic and somatic tissues.  Nrf1D-derived isoforms were present in blood plasma. Publication Status: Online-Only"
> "Q9WU00-1","RefSeq","NP_035068.3","29625129","These findings identified a negative feedback loop between miR-378 and Nrf1 that promotes the pathogenesis of hepatosteatosis"
21037a28139,28140
> "Q18PI6-1","RefSeq","NP_038517.1","27452524","Results show that CD84 expressed on CLL cells interact with CD84 expressed on cells in their microenvironment, inducing cell survival in both sides."
> "Q18PI6-1","RefSeq","NP_038517.1","27223891","CRISPR-Mediated Slamf1Delta/Delta Slamf5Delta/Delta Slamf6Delta/Delta Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects. Publication Status: Online-Only"
21039a28143
> "P97454-1","RefSeq","NP_032567.1","31004309","The luciferase reporter assay confirmed a direct interaction between miR-132-3p and Smad5. Thus, miR-132-3p maybe regulates osteoblast differentiation via Smad5 in response to cyclic tensile stress."
21041,21043d28144
< "Q62393-1","RefSeq","NP_001020433.1","28798933","The important roles of TPD52 and TPD54, which work oppositely, in the terminal differentiation of chondrocytes during endochondral ossification."
< "Q62393-1","RefSeq","NP_001020433.1","26183179","Findings uncover a new isoform-specific role for TPD52 in promoting intracellular lipid storage, which might be relevant to TPD52 overexpression in cancer."
< "Q62393-1","RefSeq","NP_001020433.1","17314271","Together, these data suggest that mD52 expression in 3T3 cells initiated cellular transformation, tumorigenesis, and progression to metastasis."
21055a28157,28161
> "P97808-1","RefSeq","NP_032787.1","28515087","FXYD5 mediates metastatic progression through regulation of the beta Na(+)-K(+)-ATPase subunit in the 4T1 mouse breast cancer model."
> "P97808-1","RefSeq","NP_032787.1","27006401","Transfection of M1 epithelial cell line with FXYD5 largely increases lipopolysaccharide (LPS) stimulated CCL2 mRNA and secretion of the translated protein"
> "P97808-1","RefSeq","NP_032787.1","24717576","FXYD5 affects cell polarization through its interaction with Na(+)-K(+)-ATPase."
> "P97808-1","RefSeq","NP_032787.1","21900457","Expressing FXYD5 in mouse kidney collecting duct cell line M1 led to a large decrease in amiloride-insensitive transepithelial electrical resistance as well as increased permeability to 4-kDa dextran."
> "P97808-1","RefSeq","NP_032787.1","16148001","The role of FXYD5 in Na,K-ATPase activity, its cellular and tissue distribution, and its biochemical properties are reported."
21057a28164,28166
> "Q78TU8-1","RefSeq","NP_899010.1","30137324","Systemic inflammation further mobilized glucocorticoid signaling and in turn led to dysregulation of a large set of genes, including robust upregulation of FAM107A in the spinal cord, increased expression of which has been implicated in neurodegeneration."
> "Q78TU8-1","RefSeq","NP_899010.1","30121783","Study showed abundant expression of down-regulated in renal cell carcinoma 1 (DRR1) mRNA and protein in the adult mouse brain with pronounced differences between distinct brain regions. Glucocorticoid receptor activation induced DRR1 expression throughout the brain, with particularly strong induction in white matter and fiber tracts and in membrane-rich structures."
> "Q78TU8-1","RefSeq","NP_899010.1","21969592","Endogenous DRR1 localizes to some, but not all, synapses, with preference for the presynaptic region. Enhancement of DRR1 expression reduced spine density, diminished the probability of synaptic glutamate release, and altered cognitive performance."
21078a28188,28192
> "Q9Z265-1","RefSeq","NP_057890.1","29859927","This study defines a role for Chk2 in suppressing UV-induced skin carcinogenesis"
> "Q9Z265-1","RefSeq","NP_057890.1","29805302","Chk2 deletion in Pthrp KI mice can somewhat rescue defects in osteoblastic bone formation and skeletal growth by enhancing endochondral bone formation and osteogenesis Publication Status: Online-Only"
> "Q9Z265-1","RefSeq","NP_057890.1","12356735","Results show that Chk2 plays a critical role in p53 function in response to IR by regulating its transcriptional activity as well as its stability"
> "Q9Z265-1","RefSeq","NP_057890.1","12097646","Role of Chk2 in p53-dependent apoptotic response"
> "Q8VI67-1","RefSeq","NP_569725.1","12647290","Osterix gene was expressed in rib cartilage-derived chondrocytes and BMP-2 treatment enhanced this expression"
21086a28201
> "Q8CB49-1","RefSeq","NP_780374.1","18256694","Tprg gene is predominantly expressed in skin, is physically associated with the p63 gene during evolution, and directly regulated by p63 through a long-distance enhancer located within the Tprg locus. GeneRIF: The Tprg gene is predominantly expressed in keratinocytes, is physically associated with the p63 gene during evolution, and is directly regulated by p63 through a long-distance enhancer located within the Tprg locus."
21091a28207,28212
> "P24527-1","RefSeq","NP_032543.2","29051536","LTA4H is the major Pro-Gly-Pro degrading enzyme. Publication Status: Online-Only"
> "P24527-1","RefSeq","NP_032543.2","28575166","These findings indicate that LTA4H is critical for skin carcinogenesis and is an important mediator of cell cycle and the data begin to clarify the mechanisms of LTA4H's role in cancer development."
> "P24527-1","RefSeq","NP_032543.2","26400771","There is a critical role for the secondary anti-inflammatory activity of LTA4H in acute pulmonary infection. Publication Status: Online-Only"
> "Q80U70-1","RefSeq","NP_954666.1","29606589","Nsd1 is a key modulator of PRC2 function required for regulating the demarcation of genome-wide H3K27me2 and H3K27me3 domains in embryonic stem cells."
> "Q80U70-1","RefSeq","NP_954666.1","29483650","SUZ12 binds to CpG islands and this stable recruitment to genomic loci is essential for correct H3K27 methylation patterns."
> "Q80U70-1","RefSeq","NP_954666.1","15385962","Here we show that mice lacking Suz12, like Ezh2 and Eed mutant mice, are not viable and die during early postimplantation stages displaying severe developmental and proliferative defects."
21092a28214,28219
> "Q9CPV9-1","RefSeq","NP_081847.3","29916540","OC formation was efficiently restored by addition of adenosine diphosphate, a P2Y12 agonist, as well as by addition of CysLT. Furthermore, similar to montelukast, P2Y12 blockade by a pharmacological inhibitor or siRNAs suppressed OC differentiation"
> "Q9CPV9-1","RefSeq","NP_081847.3","29694903","A critical role for microglial P2Y12Rs in regulating the microglial landscape through cellular translocation independent of proliferation. These findings suggest that microglial patrol the CNS through both process motility and soma translocation."
> "Q9CPV9-1","RefSeq","NP_081847.3","15464998","Results describe the cloning of DNA sequences encoding the murine ortholog of the human P2Y12 receptor, and its expression in the mouse brain."
> "Q9CPV9-1","RefSeq","NP_081847.3","12897207","Role of P2Y12 in platelet thrombosis and how its complete absence affects the thrombotic process"
> "P59240-1","RefSeq","NP_700473.2","21078623","A mutation in NPHP4 in mice does not result in renal defects which are observed in human patients with mutations in NPHP4, but they do develop severe photoreceptor degeneration and extinguished rod and cone ERG responses."
> "P59240-1","RefSeq","NP_700473.2","12205563","Recessive mutations in the NPHP4 gene, encoding the protein nephroretinin, in humans cause nephronophthisis type 4 and Senior-Loken. There is evolutionary conservation of the NPHP4 gene, with an orhtolog in C. elegans."
21097,21099d28223
< "Q9Z1B3-1","RefSeq","NP_001139302.1","27776973","Plcb1 plays a crucial role in the initiation of the genetic program responsible for muscle differentiation and osteogenesis. (Review) Review article"
< "Q9Z1B3-1","RefSeq","NP_001139302.1","27563828","Data show that phospholipase C (PLC)-beta1 (PLC-beta1) overexpression determines an increase in beta-catenin translocation and that PLC-beta1, inositol polyphosphate multikinase (IPMK) and beta-catenin are mediators of the same signaling pathway."
< "Q9Z1B3-1","RefSeq","NP_001139302.1","27342861","Functions in plasma membrane remodeling, particularly caveolae formation"
21103a28228,28230
> "Q71KU9-1","RefSeq","NP_663569.2","29111387","Endoplasmic reticulum stress induced by palmitate could increase the expression of HPS in hepatocytes and further contribute to the development of insulin resistance in skeletal muscle."
> "Q71KU9-1","RefSeq","NP_663569.2","26225745","The results suggest that Fgl1 acts as a tumor suppressor in hepatocellular cancer through an Akt-dependent mechanism and support its role as a potential therapeutic target in hepatocellular carcinoma."
> "Q71KU9-1","RefSeq","NP_663569.2","23792031","Hepassocin plays an important role in non-alcoholic fatty liver disease and induces hepatic lipid accumulation through an ERK1/2-dependent pathway. Erratum:[J Hepatol. 2017 Feb;66(2):468. PMID: 27988105]"
21117a28245,28250
> "Q9JHI9-1","RefSeq","NP_058613.2","30213870","Erythroblast-specific Ferroportin (FPN), knockout (Fpn KO) mice developed lower serum iron levels in conjunction with tissue iron overload and increased FPN expression in spleen and liver without changing hepcidin levels."
> "Q9JHI9-1","RefSeq","NP_058613.2","30073618","Expression of solute carrier family 9 (sodium/hydrogen exchanger) member 2 (Slc9a2) within the mammary gland can mediate the effect of milk mineral concentration quantitative trait loci 9 (Mmcq9) on milk iron concentration."
> "Q9JHI9-1","RefSeq","NP_058613.2","29724825","The Slc40a1 deletion mildly increased iron levels in both precursor and mature osteoclasts, and its loss in precursors, but not in mature cells, increased osteoclastogenesis and decreased bone mass in vivo Of note, these phenotypes were more pronounced in female than in male mice."
> "A6H8H5-1","RefSeq","NP_001091998.1","30091655","These findings demonstrate a conserved in vivo function for Kv2 family members in remodeling neuronal endoplasmic reticulum-plasma membrane junctions."
> "A6H8H5-1","RefSeq","NP_001091998.1","27033450","The fractional contribution of Kv2.2-mediated currents relative to IK decreases during the postnatal maturation of dorsal root ganglion neurons."
> "A6H8H5-1","RefSeq","NP_001091998.1","18511484","It was concluded that Kv2.2-containing channels have a distinctive initial segment location and crucial function in maintaining AP amplitude by regulating the interspike potential during high frequency firing."
21124a28258,28260
> "Q924Y0-1","RefSeq","NP_569719.1","29065368","BBOX 1 expression was increased in the medial frontal cortex of a mouse model of schizophrenia induced by maternal immune activation."
> "Q924Y0-1","RefSeq","NP_569719.1","21549104","Study clearly shows that mouse gamma-butyrobetaine dioxygenase is a direct PPARalpha target gene"
> "P63084-1","RefSeq","NP_035442.1","24692514","S100a5 expression is directly and rapidly increased by odor stimulation of mouse olfactory sensory neurons. [S100a5]"
21129a28266,28270
> "Q9WTM5-1","RefSeq","NP_035434.1","27469992","Ruvbl2 has a role in the differentiation of neuroectoderm during early embryogenesis."
> "Q9WTM5-1","RefSeq","NP_035434.1","26639898","Accumulating E2f1 progressively recruits a Pontin/Reptin complex to open the chromatin conformation at E2f target genes and amplifies the E2f transcriptional response. Publication Status: Online-Only"
> "Q9WTM5-1","RefSeq","NP_035434.1","25185564","Reptin plays a key role in maintaining the pluripotency of embryonic stem cells and in establishing the pluripotency during reprogramming of somatic cells by regulation of Oct4-mediated gene regulation"
> "Q9WTM5-1","RefSeq","NP_035434.1","24167278","Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression."
> "Q9WTM5-1","RefSeq","NP_035434.1","16425234","RuvBl2, which encodes an ATP-dependent DNA helicase, is specifically detected in the spermatocytes and spermatids of the adult testis as well as in primordial germ cells."
21131a28273,28276
> "Q99JA4-1","RefSeq","NP_067451.2","29916540","Montelukast also served a protective role in a murine ovariectomy (OVX) and unloadinginduced bone loss model. Altogether, these results confirmed that the CysLTR1 antagonist exerted an inhibitory effect on OC formation in vitro and in vivo. It may be useful for the treatment of bone diseases associated with excessive bone resorption."
> "Q99JA4-1","RefSeq","NP_067451.2","29412178","These findings highlight the essential role of cysLT1R in suppressing pancreatic insulin secretion, and potentially provided a new insight into understanding the mechanical regulation of glucose homeostasis."
> "Q99JA4-1","RefSeq","NP_067451.2","30183378","Cysteinyl leukotriene receptor 1 (cysLT1R) regulates osteoclast differentiation and bone resorption."
> "Q99JA4-1","RefSeq","NP_067451.2","11932261","Determination of role in enhanced vascular permeability of mice undergoing acute inflammatory responses"
21137,21138d28281
< "Q8R0S4-3","RefSeq","NP_001032176.1","27003325","Study demonstrates that the lack of the voltage-gated calcium channel beta4 subunit causes a decreased late development in cerebellar cortical networks, characterized by reduced parallel fibre-purkinje cell input, shorter purkinje cell dendrites and depressed purkinje cell output."
< "Q8R0S4-3","RefSeq","NP_001032176.1","24875574","The nuclear targeting properties of the truncated beta(4b(1-481)) subunit in tsA-201 cells, skeletal myotubes, and in hippocampal neurons, were investigated."
21149a28293,28298
> "P06869-1","RefSeq","NP_032899.1","30836238","The findings of this indicated that Plau/Plaur-deficiency leads to a more social phenotype toward other mice with diminished interest in the surrounding environment, and increased seizure susceptibility"
> "P06869-1","RefSeq","NP_032899.1","29720403","In summary, the data show that urokinase-type plasminogen activator/ the urokinase-type plasminogen activator receptor binding promotes synaptic repair in the ischemic brain via ezrin-mediated reorganization of the actin cytoskeleton in the postsynaptic terminal."
> "P06869-1","RefSeq","NP_032899.1","29420634","Data presented here reveal important information about dynamics in uPA by demonstrating how various ligands can modulate uPA activity by mediating long-range conformational changes Publication Status: Online-Only"
> "P51910-1","RefSeq","NP_031496.2","29885491","These data indicate apolipoprotein-D rarely exists as a free monomer under physiological conditions and provide insights into novel native structures of apolipoprotein-D and into oligomerisation behaviour in the lipocalin family."
> "P51910-1","RefSeq","NP_031496.2","29222871","Study shows that in myelin maturation ApoD ultimately controls the removal of the sialic-rich hydrophilic glycocalyx, by maintaining functional integrity of lysosomes. A detailed analysis of the mechanism reveals that the proper localization of Neu1 and plasma membrane Neu3, as well as of the membrane-bound Fyn kinase, depend on ApoD."
> "P51910-1","RefSeq","NP_031496.2","21632073","The findings underscore the importance of ApoD in the regulation of plasma insulin levels and triglyceride metabolism, suggesting that ApoD plays an important role in the pathogenesis of dyslipidemia."
21152a28302,28303
> "O08912-1","RefSeq","NP_038842.3","27965094","The ppGalNAc-T4 was highly expressed in MC3T3-E1 cells during osteogenesis for the first time; ppGalNAc-T1 and -T4 affected the expression of different osteogenic factors, suggesting distinct roles ppGalNAc-T isoforms play in regulating osteogenesis in vitro"
> "O08912-1","RefSeq","NP_038842.3","25615642","Study show that in Galnt1 null mouse, there is compromised cardiac function that mimics human congenital heart disease suggesting that Galnt1 expression is required for normal heart valve development. Publication Status: Online-Only"
21153a28305,28309
> "E9Q2Z1-1","RefSeq","NP_001121623.1","22154806","The results demonstrated a novel role of CECR2-containing complexes in spermatogenesis and showed that CECR2 interacts predominantly with SNF2H instead of SNF2L in the testis."
> "E9Q2Z1-1","RefSeq","NP_001121623.1","22045912","Strain-specific modifier genes of Cecr2-associated exencephaly in mice."
> "E9Q2Z1-1","RefSeq","NP_001121623.1","21246654","Data show that two independent mutations of Cecr2 are also associated with specific inner ear defects."
> "E9Q2Z1-1","RefSeq","NP_001121623.1","20589882","A novel Cecr2 null allele (Cecr2(tm1.1Hemc)) had a stronger penetrance of exencephaly than Cecr2(Gt45Bic) in both BALB/c and FVB/N strains, in addition to midline facial clefts and forebrain encephalocele in the FVB/N strain."
> "E9Q2Z1-1","RefSeq","NP_001121623.1","15640247","CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L during neurulation"
21162a28319,28321
> "Q9D2N4-1","RefSeq","NP_034217.2","26769899","A phosphorylation site on alpha-dystrobrevin-1 is essential for functional interactions with several proteins at the neuromuscular junction."
> "Q9D2N4-1","RefSeq","NP_034217.2","25636738","Loss of alpha dystrobrevin is associated with perturbation in cell cycle progression and nuclei shape."
> "Q9D2N4-1","RefSeq","NP_034217.2","25158611","Alpha-dystrobrevin is a multifunctional protein that increases dystrophin's binding to the dystrophin-glycoprotein complex."
21167c28326,28338
< "P62881-1","RefSeq","NP_034443.1","28687610","Stimulation of the ERK pathway in Gnb5(-/-) cells by epidermal growth factor restored M3R-stimulated insulin release to near normal levels. Identification of the novel role of Gbeta5-R7 in insulin secretion may lead to a new therapeutic approach for improving pancreatic beta-cell function"
---
> "Q8BUG5-1","RefSeq","NP_840062.2","30389842","Epigenetic tuning of CAPS variants may allow modulation of endocrine adrenaline and noradrenaline release"
> "Q8BUG5-1","RefSeq","NP_840062.2","28963059","That CAPS2 deficiency strongly impairs hippocampal adult neurogenesis and maturation of newborn neurons"
> "Q8BUG5-1","RefSeq","NP_840062.2","25754523","These results suggest that Caps2 KO mice have altered endocrine responses to CORT administration, while maintaining CORT-induced anxiety/depressive-like behavior. Publication Status: Online-Only"
> "Q8BUG5-1","RefSeq","NP_840062.2","25437547","Naturally occurring splice variants of CAPS2 in CAPS1/CAPS2-deficient cells were studied and found that CAPS2 primes vesicles independently of its MUN domain."
> "Q8BUG5-1","RefSeq","NP_840062.2","22111578","CAPS family proteins exert dual roles in DCV trafficking, mediating trafficking at both the secretion site for exocytosis and at the Golgi complex for biogenesis"
> "Q8BUG5-1","RefSeq","NP_840062.2","21173225","CAPS2 promotes activity-dependent brain-derived neurotrophic factor secretion during the postnatal period that is critical for the development of hippocampal GABAergic networks."
> "Q8BUG5-1","RefSeq","NP_840062.2","20302894","CAPS2 KO mice will be a useful animal model to study the aspects of the neuropathology and behavior characteristics of neurodevelopmental disorders Review article"
> "Q8BUG5-1","RefSeq","NP_840062.2","19238500","The CAPS2-deficient mice show reduced secretion of BDNF and NT-3. And the cerebella of these mice exhibit developmental deficits, such as delayed development. Review article"
> "Q8BUG5-1","RefSeq","NP_840062.2","11846421","Discusses cloning of the human homolog of mouse Caps2 (GeneID: 353025)."
> "Q9WUG6-1","RefSeq","NP_035961.1","28857318","Mass spectral analysis of purified enteroendocrine cells and tissue homogenates identified the exact sequence of A and B chains of INSL5 endogenously expressed in L-cells."
> "Q9WUG6-1","RefSeq","NP_035961.1","25028498","Insl5 is an orexigenic hormone released from colonic L-cells, which promotes appetite during conditions of energy deprivation."
> "Q9WUG6-1","RefSeq","NP_035961.1","23438439","INSL5 may be a unique marker of colorectal enteroendocrine cells, and INSL5-RXFP4 signaling might play a role in an autocrine/paracrine fashion in the colorectal epithelium and rectal neuroendocrine tumors."
> "Q9WUG6-1","RefSeq","NP_035961.1","16601133","Insulin-like peptide 5 is expressed in mouse brain and has a role in mobilization of calcium"
21180a28352,28353
> "E9QA28-1","RefSeq","NP_001028591.2","25080593","The data of this study indicated that CEACAM16 is required for striated-sheet matrix formation. Its continual expression may stabilize the noncollagenous TM matrix."
> "E9QA28-1","RefSeq","NP_001028591.2","22544735","CEACAM16 can probably form higher order structures with other tectorial membrane proteins such as alpha-tectorin and beta-tectorin and influences the physical properties of the tectorial membrane"
21189a28363,28364
> "O08795-1","RefSeq","NP_032951.1","22337885","TRIM67 regulates Ras signaling via degradation of 80K-H, leading to neural differentiation including neuritogenesis."
> "O08795-1","RefSeq","NP_032951.1","21995826","Data demonstrate the presence of a binding site on the 3'-untranslated region of NR1 mRNA for AnxA2 and show the regulation of NR1 mRNA by AnxA2, GIIbeta and a third NR1 mRNA-binding protein, which is yet to be identified."
21206a28382,28393
> "Q8BJQ2-1","RefSeq","NP_666256.2","26783108","Data suggest Usp1 down-regulation by autocleavage is critical for Usp1 to exert role in DNA interstrand crosslink repair; Usp1 role is de-ubiquitination of Fancd2 (Fanconi anemia complementation group D2) and Pcna (proliferating cell nuclear antigen)."
> "Q8BJQ2-1","RefSeq","NP_666256.2","26822809","Our results strongly suggest that Usp1 is involved in the regulation of centrosome duplication, at least in part via ID1, and Usp1 may exert its oncogenic activity, partially through inducing centrosome abnormality."
> "Q8BJQ2-1","RefSeq","NP_666256.2","24001775","Homozygous Uaf1(-/-) embryos died at embryonic day 7.5 (E7.5). These mutant embryos were small and developmentally retarded."
> "Q8BJQ2-1","RefSeq","NP_666256.2","23159736","Autocleaved Usp1 remains a deubiquitylase because its fragments remain associated with Uaf1, an enhancer of Usp1 activity, until the C-terminal fragment is selectively destroyed by the Arg/N-end rule pathway."
> "Q8BJQ2-1","RefSeq","NP_666256.2","20506303","Bone marrow from Fancd2-/- mice and Usp1-/- mice exhibited marked hematopoietic defects."
> "Q8BJQ2-1","RefSeq","NP_666256.2","19217432","Mouse Usp1 functions downstream in the Fanconi anemia pathway, and its deubiquitination is required for Fancd2 nuclear foci assembly"
> "Q9Z0S3-1","RefSeq","NP_062373.3","28811056","These findings suggest that (1) the changes in endolymphatic ion concentrations might not be involved in hair cells degeneration in Cldn14(-/-), (2) [Ca]e might be regulated by endocochlear potential in both Wt and Cldn14(-/-)."
> "Q9Z0S3-1","RefSeq","NP_062373.3","28373577","High Cldn14 is associated with hypoparathyroidism."
> "Q9Z0S3-1","RefSeq","NP_062373.3","25071082","Claudin-14-targeting miR-9 and miR-374, rather than promoter of the claudin-14 gene itself, regulated through histone deacetylation"
> "Q9Z0S3-1","RefSeq","NP_062373.3","24335970","Describe a CaSR-NFATc1-microRNA-claudin-14 signaling pathway in the kidney that underlies paracellular Ca(++) reabsorption through the tight junction"
> "Q9Z0S3-1","RefSeq","NP_062373.3","18663477","We generated claudin 11/claudin 14 double-deficient mice, which exhibit deafness, neurological deficits, and male sterility. Kidney function and ion balance are not significantly affected."
> "Q9Z0S3-1","RefSeq","NP_062373.3","12913076","To explore the role of claudin 14 in the inner ear and in other tissues we created a mouse model by a targeted deletion of Cldn14."
21218a28406
> "Q8C181-1","RefSeq","NP_997398.1","29735517","This study uncovers non-canonical functions of MBNL proteins (Mbnl1/2) that bind and promote the expression of miR-294 targets, including Cdkn1a and Tgfbr2, thereby opposing the role of miR-294 in regulating cell proliferation, apoptosis, and epithelial-mesenchymal transition (EMT)."
21225a28414,28422
> "Q3V3W4-1","RefSeq","NP_001028638.2","29437775","ZBTB2 is a novel DNA methylation-sensitive transcription factor that regulates cellular differentiation."
> "Q3V3W4-1","RefSeq","NP_001028638.2","19380588","ZBTB2 is a potential proto-oncogenic master control gene of the p53 pathway and, in particular, is a potent transcription repressor of the cell cycle arrest gene p21 by inhibiting p53 and Sp1"
> "Q9D2C7-1","RefSeq","NP_080945.1","29623489","BI1 functions as a novel microvascular guardian in cardiac IR injury that operates via inhibition of the Syk-Nox2-Drp1-mitochondrial fission signaling axis."
> "Q9D2C7-1","RefSeq","NP_080945.1","29457838","Targeting IRE1alpha-dependent NLRP3 inflammasome signaling with pharmacological agents or by BI-1 may represent a tangible therapeutic strategy for nonalcoholic steatohepatitis"
> "Q9D2C7-1","RefSeq","NP_080945.1","27576594","BI-1 protects against obesity-induced hepatic insulin resistance by regulating CYP2E1 activity and reactive oxygen species production. Erratum:[Sci Rep. 2018 Dec 20;8(1):17990. PMID: 30573756] Publication Status: Online-Only"
> "Q9D2C7-1","RefSeq","NP_080945.1","27297735","BI-1-mediated enhancement of ApoB secretion regulates hepatic lipid accumulation. Publication Status: Online-Only"
> "Q9D2C7-1","RefSeq","NP_080945.1","16478805","BI-1 provides endogenous protection of liver and kidney from endoplasmic reticulum stress and ischemia-reperfusion injury."
> "Q9D2C7-1","RefSeq","NP_080945.1","8530040","Discusses cloning of human testis enhanced gene transcript and its conservation in mouse and rat."
> "Q9D2C7-1","RefSeq","NP_080945.1","8012111","Discusses cloning of rat testis enhanced gene transcript and identification of its homolog in mouse."
21254a28452,28457
> "Q5RJI5-1","RefSeq","NP_001162044.1","27251228","Structure and inhibition analysis of the mouse SAD-B C-terminal fragment"
> "Q5RJI5-1","RefSeq","NP_001162044.1","27626661","CAST/SAD-B reaction serves as a brake on synaptic transmission"
> "Q5RJI5-1","RefSeq","NP_001162044.1","26444684","At mature pre-synaptic terminals, SAD-B regulates vesicular release probability and synaptic plasticity."
> "Q5RJI5-1","RefSeq","NP_001162044.1","17482548","Once activated, LKB1 phosphorylates and thereby activates SAD-A and SAD-B kinases, which are also required for neuronal polarization in the cerebral cortex."
> "Q5RJI5-1","RefSeq","NP_001162044.1","15705853","Results show that SAD-A and SAD-B, mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization."
> "F2Z472-1","RefSeq","NP_001298043.1","15582586","Report the gene duplication of SVS III in both mouse and rat."
21259a28463,28464
> "Q60854-1","RefSeq","NP_033280.1","28455723","Serpinb6a mRNA expression was more abundant in the male than in the female submandibular gland."
> "Q60854-1","RefSeq","NP_033280.1","23669344","Mice lacking SERPINB6A show nonsyndromic, autosomal-recessive deafness. SERPINB6A is present in the inner ear and deafness is associated with age-related progressive degeneration of the organ of Corti."
21266,21269c28471,28473
< "Q06180-1","RefSeq","NP_001120649.1","29797458","PTPN2 is an essential STAT3 repressor involved in the maintenance and induction of naive pluripotency."
< "Q06180-1","RefSeq","NP_001120649.1","29712668","TCPTP controls Insulin resistance signaling in AgRP neurons to coordinate hepatic glucose production and brown/beige adipocyte glucose uptake in response to feeding/fasting."
< "Q06180-1","RefSeq","NP_001120649.1","29444435","A dual role for myeloid PTPN2 in directly regulating inflammasome activation and IL-1beta production to suppress pro-inflammatory responses during colitis but promote intestinal tumor development, is reported."
< "Q06180-1","RefSeq","NP_001120649.1","29587266","PTPN2 overexpression in white adipose tissue could significantly reduce macrophages infiltration, the ratio of M1/M2 macrophages and the expression of pro-inflammatory cytokines in white adipose tissue , improving insulin resistance."
---
> "Q9EPU0-1","RefSeq","NP_109605.2","29959727","Downregulation of UPF1 activated the TNFR1-dependent NF-kappaB/MAPKs pathway, and promoting inflammatory responses in colon might act as a causal role in Ulcerative Colitis."
> "Q9EPU0-1","RefSeq","NP_109605.2","28128343","Status epilepticus led to increased protein levels of Up-frameshift suppressor 1 homolog (Upf1) within the mouse hippocampus. Upf1 protein levels were also higher in resected hippocampus from patients with intractable temporal lobe epilepsy. Publication Status: Online-Only"
> "Q9EPU0-1","RefSeq","NP_109605.2","27149095","Upon removal of TDRD6, the association of several mRNAs with UPF1 and UPF2 is disturbed, and the long 3' UTR-stimulated but not the downstream exon-exon junction triggered pathway of NMD is impaired.This function depends on TDRD6-promoted assembly of mRNA and decay enzymes in Chromatoid bodies . Publication Status: Online-Only"
21276,21278c28480,28481
< "Q4V9Z5-1","RefSeq","NP_001239495.1","29979789","Results show that NPC1 loss-of-function in a mouse model of Niemann-Pick type C disease leads to enhanced cleavage of BACE1 substrates Sez6 and Sez6L, in addition to APP, and that this effect most likely involves altered trafficking of BACE1 and of its substrates within the endolysosomal system. Efficacy of Sez6 cleavage by BACE1 may be spatiotemporally differently regulated in contrast to the cleavage of Sez6L. Publication Status: Online-Only"
< "Q4V9Z5-1","RefSeq","NP_001239495.1","29032200","Sez6l2 is one of the auxiliary subunits of the AMPA receptor and acts as a scaffolding protein to link GluR1 to ADD. Furthermore, Sez6l2 overexpression upregulates ADD phosphorylation, whereas siRNA-mediated downregulation of Sez612 prevents ADD phosphorylation, suggesting that Sez6l2 modulates AMPA-ADD signal transduction."
< "Q4V9Z5-1","RefSeq","NP_001239495.1","19242545","Sez6l2 expression in mouse embryos was restricted to the spinal cord and brain"
---
> "A2ANU3-1","RefSeq","NP_001078990.1","27800545","Mice with reduced SynDIG1 exhibit deficits in the structure and function of excitatory synapses. Mature synapses are still present, albeit at a significantly reduced number, suggesting that synapses can reach maturity without SynDIG1. However, the overall reduction in the number of mature synapses by multiple criteria suggests that SynDIG1 is important for normal development. Publication Status: Online-Only"
> "A2ANU3-1","RefSeq","NP_001078990.1","27445135","This study provides mechanistic insight into SynDIG1 structure and function to demonstrate that its stability and subcellular localization are regulated by activity-dependent palmitoylation"
21281c28484,28485
< "Q8BGR5-1","RefSeq","NP_780477.2","25183871","Simplet/Fam53b is required for Wnt signal transduction by regulating beta-catenin nuclear localization."
---
> "Q8BWA8-1","RefSeq","NP_766108.1","19503838","Adipogenesis is regulated by WGEF expression through DNA methylation change Publication Status: Online-Only"
> "Q8BWA8-1","RefSeq","NP_766108.1","15485661","WGEF is a RhoGEF expressed in intestine, liver, heart, and kidney"
21291a28496
> "Q8VI78-1","RefSeq","NP_598863.3","21857648","A phosphatidic acid-phospholipase A1alpha-lysophosphatidic acid-P2Y5 axis regulates differentiation of hair follicles via a tumour necrosis factor alpha converting enzyme-transforming growth factor alpha-epidermal growth factor receptor pathway. Publication Status: Online-Only"
21297d28501
< "O88587-1","RefSeq","NP_001104532.1","28801594","These results suggest that COMT is an enzyme to maintain glucose homeostasis and 2-methoxyestradiol is a potential endogenous multi-target anti-diabetic candidate. Publication Status: Online-Only"
21300c28504
< "Q99J78-1","RefSeq","NP_001268732.1","10460589","Def8 was first identified in a retroviral gene-trap screen"
---
> "P63015-1","RefSeq","NP_038655.1","16464444","Pax6 expression, analyzed using a BAC transgene, revealed the presence of a paired-less isoform in the eye and olfactory bulb."
21306a28511,28520
> "B2RX82-1","RefSeq","NP_001074893.1","28223528","We developed RgIA4, a peptide that exhibits high potency for both human and rodent a9a10 nAChRs, and was at least 1,000-fold more selective for a9a10 nAChRs vs. all other molecular targets tested, including opioid and GABAB receptors"
> "B2RX82-1","RefSeq","NP_001074893.1","18077337","Results demonstrate that alpha9(-/-) and alpha10(-/-) mice have overlapping but nonidentical phenotypes."
> "B2RX82-1","RefSeq","NP_001074893.1","11248107","Co-expression of the alpha10 subunit converts the normally weak acetylcholine-mediated activity of alpha9 to a more robustly active channel with identical physiological characteristics of the native mammalian outer hair cell cholinergic receptor."
> "Q7TS63-1","RefSeq","NP_941046.1","31366551","Zfat knockdown partially inhibited CD71(-/low)Ter119(-) to CD71(high)Ter119(-) transition of fetal liver erythroid progenitors with impairment in the elevation of CD71 expression.  Zfat plays a critical role for erythropoiesis in the fetal liver"
> "Q7TS63-1","RefSeq","NP_941046.1","27591365","Findings demonstrated that Zfat regulates the transcription of target genes by binding directly to the TSS proximal region, and that Zfat-target genes play important roles in T-cell homeostasis"
> "Q7TS63-1","RefSeq","NP_941046.1","27226588","Zfat-deficient T cells show increased numbers of autophagosomes and decreased levels of p62 protein, together indicating that Zfat deficiency promotes lysosomal FoxO1 degradation through autophagy."
> "Q7TS63-1","RefSeq","NP_941046.1","26168481","Zfat is required for peripheral T-cell homeostasis through IL-7Ralpha expression by controlling the FoxO1 protein."
> "Q7TS63-1","RefSeq","NP_941046.1","21225468","ZFAT is a critical molecule for cell survival in MEFs and MOLT-4 cells at least in part through the regulation of the apoptosis involved in the BCL-2- and IL6st-mediated pathways."
> "Q7TS63-1","RefSeq","NP_941046.1","20660741","ZFAT is indispensable for mouse embryonic development and functions as a critical transcription factor for primitive hematopoiesis through direct-regulation of Tal1, Lmo2, and Gata1"
> "Q7TS63-1","RefSeq","NP_941046.1","18329245","Study shows that ZFAT protein is expressed in B and T lymphocytes in mouse and that ZFAT regulates immune-related genes functionally important for immune responsiveness."
21308a28523,28524
> "Q9JIY2-1","RefSeq","NP_598809.1","19535458","Results suggest that Hakai is an important regulator of cell proliferation and that Hakai may be an oncoprotein and a potential molecular target for cancer treatment."
> "Q9JIY2-1","RefSeq","NP_598809.1","12165405","E-cadherin distribution and expression is altered in utricle epithelia with induction of apoptosis."
21311a28528,28531
> "Q9Z2K1-1","RefSeq","NP_032496.1","28128203","Study identified iRHOM2 as a novel regulator of K16 in humans and mice, with important implications for palmoplantar keratodermas, wound healing, inflammatory skin disease and cancers. Publication Status: Online-Only"
> "Q61012-1","RefSeq","NP_034444.1","23954591","During corticogenesis, a cilium-transduced, noncanonical IGF-1R-Gbetagamma-phospho(T94)Tctex-1 signaling pathway promotes the proliferation of neural progenitors through modulation of ciliary resorption and G1 length."
> "Q61012-1","RefSeq","NP_034444.1","23716657","Data indicate that a decrease in the Gbeta1 production in Ggamma1 knockout rods resulted in a significant reduction in proteasomal overload and caused a striking reversal of photoreceptor degeneration."
> "Q61012-1","RefSeq","NP_034444.1","23288843","Ectopically expressed cTalpha 1) forms a heterotrimeric complex with rod Gbeta(1)gamma(1), and substitutes equally for rTalpha in generating photoresponses initiated by either rhodopsin or S-cone opsin"
21342a28563,28564
> "Q9D2X5-1","RefSeq","NP_083269.4","24700590","Absence of Mau2 in neural crest cells causes a severe disruption of craniofacial development."
> "Q9D2X5-1","RefSeq","NP_083269.4","24287868","In spermatocytes, Nipbl/Mau2 then relocalises to chromocenters, whereas in oocytes it remains bound to chromosomal axes throughout prophase to dictyate arrest."
21350a28573,28577
> "Q45KJ6-1","RefSeq","NP_001026942.1","30635573","Lin28b/let-7 axis controls the duration of kidney development Publication Status: Online-Only"
> "Q45KJ6-1","RefSeq","NP_001026942.1","22976955","Rpl22 inactivation promotes neoplastic transformation by inducing expression of Lin28B"
> "Q45KJ6-1","RefSeq","NP_001026942.1","22723554","Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma."
> "Q45KJ6-1","RefSeq","NP_001026942.1","22345399","Study reports Lin28b is expressed in fetal liver and thymus, but not adult bone marrow or thymus; ectopic expression of Lin28 reprograms hematopoietic progenitor cells from adult bone marrow, endowing them with ability to mediate fetal-like lymphopoiesis"
> "Q45KJ6-1","RefSeq","NP_001026942.1","21962509","When overexpressed in mice, both Lin28a and LIN28B promotes resistance to high-fat-diet induced diabetes; conversely, muscle-specific loss of Lin28a or overexpression of let-7 results in insulin resistance and impaired glucose tolerance."
21357a28585,28595
> "Q6P8X9-1","RefSeq","NP_001074744.1","25296022","The uncharacterized gene Flattop (Fltp) is transcriptionally activated during planar cell polarity acquisition in ciliated tissues. Publication Status: Online-Only"
> "Q6P8X9-1","RefSeq","NP_001074744.1","22153975","Fltp(T2AiCre): a new knock-in mouse line for conditional gene targeting in distinct mono- and multiciliated tissues."
> "Q6P8X9-1","RefSeq","NP_001074744.1","17971504","1700009P17Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
> "Q8R1W2-1","RefSeq","NP_034482.2","18325338","Expression of GSG1 stimulates TPAP targeting to the ER, suggesting that interactions between the two proteins lead to the redistribution of TPAP from the cytosol to the ER"
> "Q99JZ7-1","RefSeq","NP_598514.1","29336487","Mig6 regulates the production of inflammatory mediators (TNF-alpha, il-1beta) through inhibiting the over activation of EGFR."
> "Q99JZ7-1","RefSeq","NP_598514.1","29843645","Study in mouse model where Mig-6 is specifically ablated only in the epithelial cells of the uterus suggests that endometrial epithelial cell proliferation is regulated by progesterone (P4) mediated Mig-6 inhibition of AKT phosphorylation, uncovering new mechanisms of P4 action. Publication Status: Online-Only"
> "Q99JZ7-1","RefSeq","NP_598514.1","28925396","Study showed that Mig-6 has an important function of tumor suppressor via inhibition of STAT3 phosphorylation in uterine epithelial cells, and the antitumor effects of progesterone are mediated by the endometrial stroma."
> "Q99JZ7-1","RefSeq","NP_598514.1","29191600","Mig-6 deficiency promotes the development of Kras(G12D)-induced lung adenoma through reducing the cell apoptosis in Kras(G12D) mouse lungs partially by activating the ErbB4 pathway."
> "Q99JZ7-1","RefSeq","NP_598514.1","16247031","The Mitogen-inducible gene 6 negatively regulates HGF/Met-induced cell migration."
> "Q99JZ7-1","RefSeq","NP_598514.1","16087873","Loss of Mig-6 leads to early onset of joint disease"
> "Q99JZ7-1","RefSeq","NP_598514.1","16007071","RALT behaves as a suppressor of EGFR signalling in mouse skin"
21363a28602,28604
> "Q8K4G5-1","RefSeq","NP_848803.3","29921413","ABLIM1 is associated with the regulation of preosteoclast motility via the PI3K/Akt/Rac1 pathway during RANKL-mediated osteoclastogenesis."
> "Q8K4G5-1","RefSeq","NP_848803.3","29904924","AbLIM1 regulated the localization of tubulin, migration, and fusion in osteoclasts. Thus, these results indicate that abLIM1 negatively controls osteoclast differentiation by regulating cell migration and fusion mediated via actin formation."
> "Q8K4G5-1","RefSeq","NP_848803.3","20487527","These results make Ablim1 a candidate for controlling aspects of left-right identity and patterning. Publication Status: Online-Only"
21387,21390d28627
< "Q5VCS6-1","RefSeq","NP_001128213.1","29733347","By conditional inactivation of Tdrd5 in postnatal male germ cells (Tdrd5cKO), we show that spermatogenesis is arrested at the round spermatid stage, and the testes of Tdrd5cKO mice are about half the weight of wildtype controls."
< "Q5VCS6-1","RefSeq","NP_001128213.1","29317670","Conditional inactivation of TDRD5 in mouse postnatal germ cells reveals that TDRD5 selectively regulates the production of pachytene piRNAs from abundant piRNA-producing precursors, with little effect on low-abundant piRNAs. Publication Status: Online-Only"
< "Q5VCS6-1","RefSeq","NP_001128213.1","21383078","TDRD5 is a novel component of the intermitochondrial cements (IMCs) and the chromatoid bodies (CBs), which are cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis."
< "Q5VCS6-1","RefSeq","NP_001128213.1","15465492","Tdrd5 expression is restricted to the male germline throughout development to adulthood"
21407,21409d28643
< "Q8R0Z2-1","RefSeq","NP_001258376.1","21625959","This result suggests that hnRNP F directs formation of the exon 4 minus variant of ENOX2"
< "Q8R0Z2-1","RefSeq","NP_001258376.1","18980249","The tissue expression of tNOX mRNA was greatest in heart, lung and liver. When these tissues were analyzed for cell size."
< "Q8R0Z2-1","RefSeq","NP_001258376.1","17115410","Data show that growth of transgenic mouse embryonic fibroblasts overexpressing tNOX is inhibited by low concentrations of the anticarcinogenic tNOX inhibitors epigallocatechin-3-gallate and phenoxodiol."
21411c28645,28649
< "Q8BWL5-1","RefSeq","NP_001165594.1","22372950","Binding of Rbms3 to the 3'UTR of Ptf1a regulates the production of the Ptf1a protein"
---
> "Q9WVQ1-1","RefSeq","NP_056638.1","28539383","In summary,MAGI-2 and Fyn protect dendrin fromNedd4-2-mediated ubiquitination and from nuclear translocation, thereby maintaining the physiologic homeostasis of podocytes, and the lack of MAGI-2 in podocytes results in FSGS."
> "Q9WVQ1-1","RefSeq","NP_056638.1","25993318","Magi2 is an essential component of the slit diaphragm complex that is required for nephrin localization and foot process formation."
> "Q9WVQ1-1","RefSeq","NP_056638.1","25653350","Elevation of S-SCAM expression in the excitatory neurons of forebrain was sufficient to induce an schizophrenia-like phenotype in mice."
> "Q9WVQ1-1","RefSeq","NP_056638.1","25271328","MAGI-2 is required for the integrity of the kidney filter and podocyte survival."
> "Q9WVQ1-1","RefSeq","NP_056638.1","14750953","Localization of synaptic scaffolding molecule (S-SCAM) at the puncta adherentia junctions formed between the mossy fibre terminals and the dendrites of CA3 pyramidal cells."
21415d28652
< "A2ABV5-1","RefSeq","NP_001041673.1","20194623","MED14 constitutes a novel anchoring point between Mediator and the N-terminal domain of PPARgamma that is necessary for functional PPARgamma-mediated recruitment of Mediator and transactivation of PPARgamma subtype-specific target genes."
21423a28661,28666
> "Q5NCY0-1","RefSeq","NP_001017426.1","30626691","It confirmed that the trimethylation level of histone H3K27 in the Prdm1 gene loci in the Utx KO cells was higher than in the WT cells."
> "Q5NCY0-1","RefSeq","NP_001017426.1","30389724","Overexpression of the H3K27me3-specific demethylase KDM6A, but not of KDM6B, improves the efficiency of somatic cell nuclear transfer."
> "Q5NCY0-1","RefSeq","NP_001017426.1","30135572","Mechanistic exploration identified a physical and functional association of JMJD3 with C/EBPbeta that presides the regulatory network of JMJD3. Publication Status: Online-Only"
> "Q5NCY0-1","RefSeq","NP_001017426.1","18003914","UTX and JMJD3 may function as H3K27 demethylases in vivo GeneRIF: JMJD3 demethylates di- and trimethylated lysine 27 of histone H3 in vitro and in cells."
> "Q5NCY0-1","RefSeq","NP_001017426.1","17928865","Data reveal that SMRT represses expression of JMJD3, a direct retinoic-acid-receptor target that functions as a histone H3 trimethyl K27 demethylase and which is capable of activating specific components of the neurogenic program"
> "Q5NCY0-1","RefSeq","NP_001017426.1","17825402","Jmjd3 binds polycomb group protein target genes and regulates their histone H3 lysine 27 trimethylation levels and transcriptional activity. Provides a link between inflammation and reprogramming of the epigenome."
21429a28673,28674
> "Q80ZI1-1","RefSeq","NP_001074625.1","28504339","Data suggest that neurons in mouse brain exhibit DNA sequence encoding protein precursor, proMexneurin, that contains three peptide sequences: Mexneurin-1 (an endomorphin1-like peptide), Mexneurin-2 (an endomorphin1-like peptide), and Mexneurin-3 (peptide which appears to be unrelated to endomorphins); neurons exhibit expression of proMexneurin mRNA throughout mouse brain."
> "Q80ZI1-1","RefSeq","NP_001074625.1","23622239","Study identified Trnp1 as a regulator of mammalian brain development and as a key factor controlling neocortical expansion. Trnp1 levels have striking effects on tangential, radial, and lateral expansion of the cerebral cortex."
21436,21444d28680
< "Q9D2A5-1","RefSeq","NP_001294863.1","30121191","Tisp40 deficiency limits renal inflammation and promotes tubular cell proliferation in renal ischemia reperfusion injury."
< "Q9D2A5-1","RefSeq","NP_001294863.1","28778797","Tisp40 aggravates tubular cells apoptosis in renal ischemia reperfusion injury."
< "Q9D2A5-1","RefSeq","NP_001294863.1","28618421","These findings suggest that Tisp40 plays a critical role in the TGF-beta/ Smads pathway involved in this process. Hence, Tisp40 could be a useful therapeutic target in the fight against renal tubulointerstitial fibrosis"
< "Q9D2A5-1","RefSeq","NP_001294863.1","25412305","Creb3l4 is an essential negative regulator of adipogenesis. Publication Status: Online-Only"
< "Q9D2A5-1","RefSeq","NP_001294863.1","16925989","Expression of full-length ATCE1 in various cell lines revealed ER and Golgi localization whereas truncation of the C-terminus allowed entrance into the nucleus. A speculation that ATCE1 might be paternally delivered to newly formed zygote is discussed."
< "Q9D2A5-1","RefSeq","NP_001294863.1","16728718","We show that Atce1/Tisp40alpha is the major form of CREB3L4 in mouse testis. These findings suggest that testis-specific isoforms of Creb3l4 could play an important role in spermatid differentiation."
< "Q9D2A5-1","RefSeq","NP_001294863.1","16595651","Tisp40 and CREM bind to the Tisp40 promoter in vivo"
< "Q9D2A5-1","RefSeq","NP_001294863.1","16107712","Creb3l4 plays a role in male germ cell development"
< "Q9D2A5-1","RefSeq","NP_001294863.1","15938716","TISP40 functions by binding to the unfolded protein response element via the Rip pathway."
21451,21452d28686
< "Q9JLB9-1","RefSeq","NP_067470.1","28872640","Nectin-3 expressed in dentate gyrus neurons may modulate adult neurogenesis, dendritic spine plasticity and the cognitive effects of early-life stress. Publication Status: Online-Only"
< "Q9JLB9-1","RefSeq","NP_067470.1","12121624","Nectin-afadin system plays essential roles in coupling cell-cell adhesion and the cortical actin scaffold in spermatids at Sertoli-spermatid junctions and in subsequent sperm morphogenesis"
21459a28694
> "Q9JMB1-1","RefSeq","NP_954696.1","12748127","Deletion of either the C-terminal or N-terminal regions of the Theg protein did not affect spermatogenesis or fertility in the mouse."
21463,21464d28697
< "Q99246-2","RefSeq","NP_001289566.1","29733375","Data show that editing of Cav1.3 calcium channel (CaV1.3) was potently inhibited by serine/arginine-rich splicing factor 9 (SRSF9)."
< "Q99246-2","RefSeq","NP_001289566.1","30001160","The molecular interactions engaging D4 in VSD IV contribute to voltage-sensing in all examined CaV1.3 channel, however its striking role in regulating the gating properties by alternative splicing appears to be a unique property of the skeletal muscle CaV1.1 channel."
21466a28700,28703
> "O88878-1","RefSeq","NP_033577.1","30254168","Unlike other proteasome regulators, ZFAND5 enhances multiple 26S activities and overall cellular protein breakdown. Erratum:[Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1458. PMID: 30642959]"
> "O88878-1","RefSeq","NP_033577.1","22665488","Zfand5 can enhance ARE-containing mRNA stability by competing with tristetraprolin for mRNA binding."
> "O88878-1","RefSeq","NP_033577.1","16424905","ZNF216 functions in protein degradation via the UPS and plays a crucial role in muscle atrophy."
> "O88878-1","RefSeq","NP_033577.1","16194934","ZNF216 is a potent inhibitory factor for osteoclast differentiation and the mechanism is unlikely due to direct attenuation of the NF-kappa B pathway"
21470a28708,28710
> "Q8C0V0-1","RefSeq","NP_766252.2","29321513","Our data suggest that Tlk1 negatively regulates the expression of pluripotency factors, thereby contributing to the scheduled differentiation of mouse ESCs. Publication Status: Online-Only"
> "Q8C0V0-1","RefSeq","NP_766252.2","28708136","TLK1 and TLK2 have largely redundant roles in genome maintenance."
> "Q8C0V0-1","RefSeq","NP_766252.2","20021694","Present direct evidence that TLK1B can promote repair of linearized plasmids with incompatible ends that require processing prior to ligation. Publication Status: Online-Only"
21471a28712,28717
> "Q9D1H0-1","RefSeq","NP_598669.1","28487372","Structural and biophysical studies demonstrate that RITA binds RBP-J similarly to the RAM (RBP-J-associated molecule) domain of Notch, our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J."
> "Q9QXT0-1","RefSeq","NP_064337.1","28981072","Sustained PERK activation can amplify PERK signaling by further enhancing CNPY2 expression via direct transactivation through CHOP."
> "Q9QXT0-1","RefSeq","NP_064337.1","28869608","Free CNPY2 then engages protein kinase R-like endoplasmic reticulum kinase (PERK) to induce expression of the transcription factor C/EBP homologous protein (CHOP), thereby initiating the unfolded protein response."
> "Q9QXT0-1","RefSeq","NP_064337.1","26835537","CNPY2 may play a critical role in colorectal cancer development by enhancing cell proliferation, migration, and angiogenesis and by inhibiting apoptosis through negative regulation of the p53 pathway"
> "Q9QXT0-1","RefSeq","NP_064337.1","25589425","CNPY2 is a HIF-1alpha-regulated, secreted angiogenic growth factor that promotes smooth muscle cell migration, proliferation, and tissue revascularization."
> "Q9QXT0-1","RefSeq","NP_064337.1","25393402","The data demonstrate CNPY2 is widely distributed in tissues and suggest the protein has biological functions that have yet to be identified. Publication Status: Online-Only"
21473a28720
> "P39689-1","RefSeq","NP_031695.1","20231440","Tested the hypothesis that p21 down-regulation could functionally induce a regenerative response in an appendage of an otherwise nonregenerating mouse strain"
21487a28735,28738
> "E9Q616-1","RefSeq","NP_033773.1","28468000","Ahnak1 plays a protective role in vascular healing after wire injuries."
> "E9Q616-1","RefSeq","NP_033773.1","26987950","Findings suggest an important role of AHNAK in the regulation of thermogenesis and lipolysis in white adipose tissue via beta-adrenergic signaling. Publication Status: Online-Only"
> "E9Q616-1","RefSeq","NP_033773.1","21940993","AHNAK constitutes a novel mechanism in post-transcriptional control of gene expression."
> "E9Q616-1","RefSeq","NP_033773.1","12617833","Localized to sites of major morphogenesis during mouse placentation and neurulation.  Role in tissue union during normal mouse development."
21491a28743,28744
> "Q9JLB9-1","RefSeq","NP_067472.1","28872640","Nectin-3 expressed in dentate gyrus neurons may modulate adult neurogenesis, dendritic spine plasticity and the cognitive effects of early-life stress. Publication Status: Online-Only"
> "Q9JLB9-1","RefSeq","NP_067472.1","12121624","Nectin-afadin system plays essential roles in coupling cell-cell adhesion and the cortical actin scaffold in spermatids at Sertoli-spermatid junctions and in subsequent sperm morphogenesis"
21492a28746,28747
> "Q8BG39-1","RefSeq","NP_705807.2","25730372","To study the role of SV2B in maintaining the podocyte function and to better understand the function of the neuron-like vesicle expressing SV2B in the podocyte, we analyzed them with SV2B knockout (KO) mice."
> "A2AVJ5-1","RefSeq","NP_780390.3","22609986","PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12 in fibroblasts and pulmonary fibrosis. Publication Status: Online-Only"
21494a28750,28752
> "P54751-1","RefSeq","NP_033203.1","26552809","ST3GAL-1 is an independent adverse prognostic factor for recurrence and survival of patients with clear cell renal cell carcinoma Publication Status: Online-Only"
> "P54751-1","RefSeq","NP_033203.1","20653283","Tryptophan and cysteine residues conserved in ST3Gal I are critical for its activity"
> "P54751-1","RefSeq","NP_033203.1","10755614","St3gal-1 functions to protect CD8 T cells from apoptosis"
21504a28763,28764
> "Q8BP97-1","RefSeq","NP_796344.1","24859449","Report that Rhbdd3, a member of the rhomboid family of proteases, suppressed the activation of dendritic cells and production of interleukin 6 (IL-6) triggered by Toll-like receptors"
> "Q8BP97-1","RefSeq","NP_796344.1","23610400","Rhbdd3 is a feedback inhibitor of TLR3-triggered NK cell activation"
21517,21520c28777,28779
< "Q8CE08-1","RefSeq","NP_062781.2","27783536","These findings demonstrate that PAP secreted by PCa cells in OB bone metastases increases osteoprotegerin and plays a critical role in the vicious cross talk between cancer and bone cells."
< "Q8CE08-1","RefSeq","NP_062781.2","27348306","PAP-immunoreactivity was present in type I and one of type III taste cells of taste buds. Thus, it is suggested that PAP might be a responsible ectoenzyme for metabolism of extracellular nucleotides, being involved in the regulation of taste signaling in taste buds. Publication Status: Online-Only"
< "Q8CE08-1","RefSeq","NP_062781.2","27306411","Functional PAP(thorn) neurons are essential for the analgesic effect, which is mediated by NGF-trkA signaling. Publication Status: Online-Only"
< "Q8CE08-1","RefSeq","NP_062781.2","19158948","PAP has species-conserved antinociceptive effects and has pH-dependent ectonucleotidase activity"
---
> "P54830-1","RefSeq","NP_038671.2","29948948","STEP61 undergoes proteolytic degradation in conditions leading to synaptic strengthening and memory formation"
> "P54830-1","RefSeq","NP_038671.2","30176350","Deletion of STEP has a beneficial effect on motor coordination and cognition in a mouse model of Huntington's disease."
> "P54830-1","RefSeq","NP_038671.2","29508281","STEP plays an important role at nerve terminals in the regulation of Ca(2+) homeostasis and neurotransmitter release."
21525a28785,28788
> "Q9Z1L3-1","RefSeq","NP_035745.3","21135503","In uteri of Dedd-/- mice, development of the decidual zone and the surrounding edema after embryonic implantation was defective. This was accompanied by disintegration of implantation site structure, leading to embryonic death before placentation."
> "Q9Z1L3-1","RefSeq","NP_035745.3","20043882","DEDD plays an important role in maintenance of the Akt protein level, which in consequence supports the efficient incorporation of glucose into skeletal muscles and adipose tissues."
> "Q9Z1L3-1","RefSeq","NP_035745.3","19106089","The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation."
> "Q9Z1L3-1","RefSeq","NP_035745.3","19260450","It regulates cell cycle and cell sizing. (review) Review article"
21527,21530d28789
< "Q3U8K7-1","RefSeq","NP_001161357.1","27920088","Suv4-20h1/h2 are mostly absent in mouse embryos before implantation, underscoring a rapid decrease of H4K20me3 from the two-cell stage onward"
< "Q3U8K7-1","RefSeq","NP_001161357.1","26669898","Suv4-20h1, an H4K20 dimethyltransferase, controls Skeletal muscle stem cell quiescence by promoting formation of facultative heterochromatin."
< "Q3U8K7-1","RefSeq","NP_001161357.1","23720823","This study suggests a novel role of FRG1 as epigenetic regulator of muscle differentiation and indicates that Suv4-20h1 has a gene-specific function in myogenesis."
< "Q3U8K7-1","RefSeq","NP_001161357.1","17846168","There is a novel role for histone lysine methylation in controlling telomere recombination."
21564a28824,28828
> "A2AP18-1","RefSeq","NP_780765.2","23237262","The role of PLCeta2 in neuritogenesis was assessed during retinoic acid (RA)-induced Neuro2A cell differentiation"
> "A2AP18-1","RefSeq","NP_780765.2","20060933","PLCeta2 exhibited a dynamic expression pattern during postnatal retinal development, strongly suggesting that this isozyme might be involved in the development and maturation of the retina."
> "A2AP18-1","RefSeq","NP_780765.2","16107206","The molecular cloning and sequencing of phospholipase C eta2 are reported."
> "A2AP18-1","RefSeq","NP_780765.2","15899900","PLC(eta)2 is a neuron-specific isozyme that may be important for the formation and/or maintenance of the neuronal network in the postnatal brain"
> "A2AP18-1","RefSeq","NP_780765.2","15583837","Molecular cloning of PLC-eta1 and PLC-eta2."
21567a28832,28835
> "Q8BHB3-1","RefSeq","NP_766430.3","23307938","SIT and LAX are important negative regulators of immune responses that functionally cooperate."
> "Q8BHB3-1","RefSeq","NP_766430.3","16672218","LAX negatively regulates mast cell function"
> "Q8BHB3-1","RefSeq","NP_766430.3","15843560","Upon T or B cell activation, the LAX protein is up-regulated dramatically. This in vivo study of LAX-deficient mice demonstrates that LAX functions as a negative regulator in lymphocyte signaling."
> "P62812-1","RefSeq","NP_034380.1","29109059","This experiments show that loop F of the alpha-subunit governs the potency of GABA on alpha2 and alpha5-GABAA receptors in vitro as well as in vivo."
21581a28850,28853
> "Q9D1N4-1","RefSeq","NP_079652.1","28860190","These data reveal that myoblast fusion requires myomaker activity at the plasma membrane and is potentially regulated by proper myomaker trafficking."
> "Q9D1N4-1","RefSeq","NP_079652.1","26858401","Data indicate that the majority of myomaker is embedded in the plasma membrane with seven membrane-spanning regions and a required intracellular C-terminal tail."
> "Q9D1N4-1","RefSeq","NP_079652.1","25085416","Myogenic basic helix-loop-helix (bHLH) transcription factors induce myomaker expression in satellite cells during acute and chronic muscle regeneration."
> "Q9D1N4-1","RefSeq","NP_079652.1","23868259","The findings reveal myomaker (transmembrane protein 8c) as a long-sought myogenic fusion protein that controls mammalian myoblast fusion."
21604a28877,28880
> "Q8R4R6-1","RefSeq","NP_081367.1","30195030","The results suggest that Nup35 is putatively phosphorylated and released to the cytoplasm after resumption of meiosis, and it regulates spindle assembly and chromosome alignment."
> "Q8R4R6-1","RefSeq","NP_081367.1","27427419","Our study also raises the possibility that Nup35 polymorphisms could contribute to some cases of Chronic intestinal pseudo-obstruction"
> "Q8R4R6-1","RefSeq","NP_081367.1","16962612","The crystal structure of the Nup35 RNA-recognition motif (RRM) domain has been solved; the Nup35 RRM domain monomer adopts the characteristic betaalphabetabetaalphabeta topology revealing a new homodimerization mode."
> "Q78KK3-1","RefSeq","NP_032793.2","9802569","Slc22a18/Itm gene is imprinted, with preferential expression from the maternal allele in fetal, newborn and most adult tissues, but biallelic expression in adult kidney and liver."
21607a28884,28885
> "Q921U8-1","RefSeq","NP_038898.2","18678771","Smoothelins as key determinants of arterial smooth muscle contractility and cardiovascular performance"
> "Q921U8-1","RefSeq","NP_038898.2","16285958","Smoothelin-A is essential for functional contractility of intestinal smooth muscle."
21615a28894
> "Q6P8Y7-1","RefSeq","NP_079988.3","24914955","These data support a model in which SNX31 mediates the endocytic degradation of uroplakins. Publication Status: Online-Only"
21617a28897,28902
> "P97438-1","RefSeq","NP_034737.2","30573346","These findings identify TREK1 as a potential molecular targets in migraine."
> "P97438-1","RefSeq","NP_034737.2","30153110","These findings indicate a central role for cardiac fibroblast TREK-1 in the pathogenesis of pressure overload-induced cardiac dysfunction and serve as a conceptual basis for its inhibition as a potential therapy."
> "P97438-1","RefSeq","NP_034737.2","28839101","Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins"
> "P97438-1","RefSeq","NP_034737.2","29042297","Data demonstrate that inhibition of TWIK-related K(+) channel-1 (TREK-1) protects mice from cognitive impairment induced by anesthesia and TREK-1 is a potential therapeutic target against memory impairment induced by volatile anesthetics."
> "Q9JJY4-1","RefSeq","NP_059093.3","18258677","Diverse functions for murine DP103, with an obligatory role during early embryonic development and also in modulation of steroidogenesis."
> "Q9JJY4-1","RefSeq","NP_059093.3","15713642","DP103 directly interacts with sumoylated SF-1 and is coupled to transcriptional repression by protein sumoylation."
21618a28904,28905
> "P62932-1","RefSeq","NP_001032398.1","22033112","The Fbxo40 is muscle specific in expression and is upregulated during differentiation."
> "P62932-1","RefSeq","NP_001032398.1","17928169","FBXO40 may function as a regulator involved in the postnatal myogenesis."
21625a28913,28914
> "Q923D5-1","RefSeq","NP_068360.4","16162498","SIPP1 is a positive regulator of pre-mRNA splicing that is regulated by nucleocytoplasmic shuttling"
> "Q923D5-1","RefSeq","NP_068360.4","14640981","Identification of SIPP1 as a pre-mRNA splicing factor and a binding partner of protein phosphatase-1."
21630a28920,28922
> "P09925-1","RefSeq","NP_038705.2","29696791","Many proteins and metabolites are downregulated in Surf1(-/-) adipose tissue and reversed by Dietary restriction (DR), while in brain, most metabolites that changed were elevated in Surf1(-/-) mice."
> "P09925-1","RefSeq","NP_038705.2","27208630","Fibroblasts from Surf1(-/-) mice are significantly more resistant to cell death caused by oxidative stress induced by paraquat or tert-Butyl hydroperoxide compared to cells from wild-type mice. In contrast, Surf1(-/-) fibroblasts show no difference in sensitivity to hydrogen peroxide stress"
> "P09925-1","RefSeq","NP_038705.2","26804654","Studies support the view that COX assembly is much more dependent on SURF1 in humans than in mice."
21631a28924,28927
> "Q80TF3-1","RefSeq","NP_001098716.1","29159962","Study investigated the expression pattern of Pcdh19 and Ncdh in limbic structures at four postnatal stages of C57BL/6J mice by using double-label in situ hybridization. Results confirm a strong expression of both, Ncdh and Pcdh19, in structures of the limbic system with overlapping expression patterns particularly within regions of the amygdala, the hippocampus and the ventral hypothalamus."
> "Q80TF3-1","RefSeq","NP_001098716.1","29301106","Our results highlight the role of PCDH19 in determining cell adhesion affinities during cortical development"
> "Q80TF3-1","RefSeq","NP_001098716.1","28724954","These results suggest that Pcdh19 is required for behavioral control in mice, but its genetic loss differentially affects the male and female behavior, as seen in human, and they also support the hypothesis that the mosaic expression of Pcdh19 in brains perturbs neuronal interactions. Publication Status: Online-Only"
> "Q80TF3-1","RefSeq","NP_001098716.1","16682261","Pcdh19 gene is developmentally regulated during mouse organogenesis and shows a unique expression profile among protocadherins."
21658a28955,28957
> "Q99K23-1","RefSeq","NP_619609.1","21228277","Structure of ubiquitin-fold modifier 1-specific protease UfSP2."
> "E9Q793-1","RefSeq","NP_001074590.1","29211732","Work shows that JHY does not only control ciliogenesis, but is a crucial component of the ependymal differentiation process, with ciliary defects likely a consequence of altered ependymal differentiation Publication Status: Online-Only"
> "E9Q793-1","RefSeq","NP_001074590.1","23906841","Juvenile hydrocephalus transgenic mice (Jhy(lacZ)) inherit communicating hydrocephalus in an autosomal recessive fashion with dilation of the lateral ventricles."
21663a28963,28967
> "O70310-1","RefSeq","NP_032733.1","18178842","NMT1 is essential for proper monocytic differentiation of the mouse bone marrow cells."
> "O70310-1","RefSeq","NP_032733.1","16123142","NMT1 and NMT2 have only partially overlapping functions; NMT1 is critical for tumor cell proliferation"
> "Q62189-1","RefSeq","NP_056597.3","27658936","We found that only the modified U1 snRNA (IVS-AAA) that completely matched both the intronic and exonic U1 binding sequences of the mutated DDC gene could correct splicing errors of either the mutated human DDC minigene or the mouse artificial splicing construct in vitro"
> "Q62189-1","RefSeq","NP_056597.3","24362020","A new mechanism for regulating SMN levels and provides new insight into the roles of U1A in 3' processing of mRNAs."
> "Q62189-1","RefSeq","NP_056597.3","16373497","Endogenous non-snRNP associated U1A inhibits poly(A) polymerase activity proportional to U1A recovered, suggesting that available U1A level alone is responsible for changes in its inhibitory effect at the secretory IgM poly (A) site."
21675d28978
< "Q9QWT9-1","RefSeq","NP_001182227.1","23807208","Knockdown of KIFC5A dramatically reduces ciliogenesis."
21690a28994,28995
> "P42682-1","RefSeq","NP_001276424.1","26466958","Taken together, these data indicate that ITK plus RLK inhibition may have therapeutic potential in Th1-mediated inflammatory diseases."
> "P42682-1","RefSeq","NP_001276424.1","22403441","TXK plays an overlapping role with ITK in iNKT cell development and function. ITK also has a unique function in the survival of iNKT cells, likely via a p53-dependent pathway."
21693,21694c28998
< "Q811D0-1","RefSeq","NP_001239364.1","29995933","Subjecting SAP97-cKO mice to a battery of behavioral tests revealed a subtle male-specific cognitive deficit and female-specific motor deficit, while other behaviors were largely unaffected. These data suggest that loss of SAP97 may have a modest contribution to organismal behavior. Publication Status: Online-Only"
< "Q811D0-1","RefSeq","NP_001239364.1","28103480","Adrenergic modulation of Kv1.1 was mediated by the signaling scaffold SAP97, which, through direct protein-protein interactions, escorts beta2 signaling to remove Kv1.1 from the dendrite surface. This process promoted spike timing-dependent long-term synaptic potentiation at mouse hippocampal excitatory synapses."
---
> "P01108-1","RefSeq","NP_001170825.1","31138796","C-Myc regulates both sebocyte proliferation and differentiation in sebaceous glands. Publication Status: Online-Only"
21695a29000,29007
> "Q0QWG9-1","RefSeq","NP_579933.1","18509461","Findings are compatible with the idea that LTD induction at PF-PC synapses is a crucial rate-limiting step in optokinetic resonse gain-increase adaptation, a simple form of motor learning Publication Status: Online-Only"
> "Q0QWG9-1","RefSeq","NP_579933.1","16168524","Results show that the Delphilin protein exhibits diversity at its N-terminus by variable usage of the first several exons."
> "Q0QWG9-1","RefSeq","NP_579933.1","12628171","Absence of GRID2 receptors in heteroallelic mutants induces an early and massive Purkinje cell death that is correlated with early signs of autophagy and is independent of depolarization."
> "Q0QWG9-1","RefSeq","NP_579933.1","12372286","A direct link exists between GluR2delta receptor and stimulation of the autophagic pathway in dying Purkinje cells of lurcher mice."
> "Q99N16-1","RefSeq","NP_077764.2","26613087","CYP4F18-deficient neutrophils exhibit increased chemotaxis to complement component C5a."
> "Q99N16-1","RefSeq","NP_077764.2","24632148","It is concluded that CYP4F18 is necessary for omega oxidation of leukotriene B4 in neutrophils, and is not compensated by other CYP enzymes"
> "Q99N16-1","RefSeq","NP_077764.2","17081494","The mRNA levels of Cyp4f18 increase with the development of allergic inflammation in the lung."
> "Q99N16-1","RefSeq","NP_077764.2","16380383","CYP4F18 is a critical protein in the regulation of LTB(4) metabolism"
21699d29010
< "O35453-1","RefSeq","NP_001103722.1","12962630","Crystal structure of human hepsin, confirming cleavage and association of the two chains"
21701a29013,29016
> "Q60636-1","RefSeq","NP_031574.2","31138796","Blimp1 is expressed in cells found at the base of the sebaceous gland (SG), as well as in differentiated SG cells and interfollicular epidermal (IFE) granular cells. These findings suggest that Blimp1 does not mark a distinct cell population but is expressed in SG progenitors, mature sebocytes, and differentiated IFE cells, as recently reported. Publication Status: Online-Only"
> "Q60636-1","RefSeq","NP_031574.2","22733990","Alternative splicing regulates Blimp-1 recruitment of corepressors and DNA binding activity."
> "Q9WVA3-1","RefSeq","NP_033904.2","27177335","Data show that Zfp207 binds to Bub3 to form a complex and maintains its protein level in oocytes, and that overexpression of Bub3 is able to partially rescue the occurrence of aneuploid eggs in Zfp207-depleted oocytes."
> "Q9WVA3-1","RefSeq","NP_033904.2","12011073","Cenpa, Cenpb, and Bub3, but not Cenpc, interacted with PARP-1"
21703a29019,29024
> "O35613-1","RefSeq","NP_031855.3","30335163","A lncRNA ChRO1 specifically associates with ATRX/DAXX/H3.3 complex at chromocenters to promote H3.3 incorporation and transcriptional induction of satellite repeats, which is essential for chromocenter clustering thus unveiling a mechanism involving a lncRNA that plays a role in large-scale heterochromatin reorganization and cell differentiation."
> "O35613-1","RefSeq","NP_031855.3","30336783","DAXX can induce ovarian cancer ascites formation by activating the ERK signal pathway and binding to CEBP-beta. Publication Status: Online-Only"
> "O35613-1","RefSeq","NP_031855.3","29903771","The data support a tumor suppressor role for DAXX as low-dose ionizing radiation produced a higher proportion of carcinomas in Daxx heterozygous mice than wild-type controls. While DAXX has important in vivo functions, they are independent of an inhibitory role on the p53 tumor suppressor pathway."
> "O35613-1","RefSeq","NP_031855.3","29906705","DAXX plays an important role in cisplatin resistance in ovarian cancer"
> "O35613-1","RefSeq","NP_031855.3","28358373","Data support a model in which activation of myogenic differentiation results in PML NB loss, chromatin reorganization and DAXX relocalization, and provides a paradigm for understanding the consequence of PML loss in other cellular contexts, such as during cancer development and progression Publication Status: Online-Only"
> "E9Q5L8-1","RefSeq","NP_001138532.1","27016726","Knockdown of GLYATL3 in the mouse neuroblastoma cells resulted in a decrease in the levels of the N-acylglycines and the primary fatty acid amides."
21705,21706c29026,29029
< "Q9QWZ1-1","RefSeq","NP_001276376.1","23468651","HUS1 acts as a component of the canonical 9-1-1 complex during meiotic prophase I to promote DSB repair and further propose that RAD1 and TOPBP1 respond to unsynapsed chromatin through an alternative mechanism that does not require RAD9 or HUS1."
< "Q9QWZ1-1","RefSeq","NP_001276376.1","21637962","The rad1 protein is required for repairing DNA lesions induced by UV-light, HU and gamma rays, and for mediating G(2)/M and S/M checkpoint controls."
---
> "O70252-1","RefSeq","NP_034573.2","30099287","This study demonstrated that HO-2 is involved in reducing inflammatory responses mediated by macrophages. Downstream factors (TNF-alpha, IL1beta and IL-6) that play a role in the TLR4 signaling pathway were suppressed in HO-2 overexpressing macrophages. HO-2 enhanced the survival of allografted skin."
> "O70252-1","RefSeq","NP_034573.2","29849867","Decreased oxygen consumption and increased mitochondrial ROS production in response to hypoxia were dependent upon HO-2 expression. HO-2 expression regulated HIF-1alpha and JNK signaling in a mitochondrial ROS-dependent manner. Publication Status: Online-Only"
> "O70252-1","RefSeq","NP_034573.2","26831741","This study demonstrated that Deletion of the heme oxygenase-2 aggravates brain injury following stroma-free hemoglobin-induced Publication Status: Online-Only"
> "Q9CXY1-1","RefSeq","NP_082499.3","26317472","TMEM175 comprises a potassium (K) channel that underlies the molecular mechanism of lysosomal K(+) permeability."
21737a29061,29065
> "Q80ZD9-1","RefSeq","NP_835215.1","29924804","The authors report the identification of Amigo2 as a new mediator of invasion in breast cancer. Publication Status: Online-Only"
> "Q80ZD9-1","RefSeq","NP_835215.1","28119027","AMG2KO mice exhibited ameliorated experimental autoimmune encephalomyelitis, dampened spinal T-cell accumulation, decreased serum IL-17A levels and enhanced splenic IL-10 production."
> "Q80ZD9-1","RefSeq","NP_835215.1","28272394","Amigo2, which is a member of the Amigo family that shows high species conservation, may be involved in determining liver metastasis by preferential adhesion of the tumour cells to liver endothelial cells. Publication Status: Online-Only"
> "Q80ZD9-1","RefSeq","NP_835215.1","22314660","Report AMIGO2 mRNA expression in CA2/Ca3a hippocampal region of mouse brain."
> "Q80ZD9-1","RefSeq","NP_835215.1","12843293","Expression of ali1 promotes depolarization-dependent survival of cerebellar granule neurons. Mouse ali1 mapped to a chromosome 15 locus syntenic to candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12."
21746,21748d29073
< "P60670-1","RefSeq","NP_001181952.1","26112410","The study revealed a regulatory role of the p97-Npl4-Ufd1 complex in regulating a partial degradation of the NF-kappaB subunit p100."
< "P60670-1","RefSeq","NP_001181952.1","17491009","Structural analysis of the p97-Npl4-Ufd1 interface"
< "P60670-1","RefSeq","NP_001181952.1","16103111","The p97-Ufd1-Npl4 complex couples ubiquitinated IP(3) receptors to proteasomal degradation and, thus, plays a key role in IP(3) receptor processing"
21777a29103,29109
> "Q91WA9-1","RefSeq","NP_620405.3","23584088","Transplantation of bone marrow deficient in ABCG4, a transporter of unknown function, into Ldlr(-/-) mice resulted in thrombocytosis, accelerated thrombosis and atherosclerosis"
> "Q91WA9-1","RefSeq","NP_620405.3","19633360","The loss of ABCG1 and/or ABCG4 from the CNS results in changes in metabolic pathways and in behavior."
> "Q91WA9-1","RefSeq","NP_620405.3","18039927","A role for Abcg4 in sterastrocyol efflux in the brain, Abcg4 promotes efflux of cholesterol, desmosterol, and possibly other sterol biosynthetic intermediates to HDL."
> "Q91WA9-1","RefSeq","NP_620405.3","17916878","Based on the results, we propose that ABCG1 and ABCG4 mediate the intracellular vesicular transport of cholesterol/sterols within both neurons and astrocytes to regulate cholesterol transport in the brain"
> "Q91WA9-1","RefSeq","NP_620405.3","15210959","ABCG1 and ABCG4 promote cholesterol efflux from cells to HDL"
> "Q9Z218-1","RefSeq","NP_997165.2","24225951","WT PrP(C), in a DPP6-dependent manner, modulated Kv4.2 channel properties, causing an increase in peak amplitude"
> "Q9Z218-1","RefSeq","NP_997165.2","23912628","Dipeptidyl-peptidase 6 has an unexpected but important role in cell adhesion and motility, impacting the hippocampal synaptic development and function."
21780a29113,29115
> "Q61114-1","RefSeq","NP_700467.2","28851744","BPIFB1 is a novel regulator of MUC5B expression in airway mucosa."
> "Q61114-1","RefSeq","NP_700467.2","26769076","Bpifb1 mRNA is upregulated in parotid acinar cells in NOD mice, but its expression is not related to the onset of diabetes. These findings suggest that high expression levels of Bpifb1 might predict disease traits before the onset of autoimmunity."
> "Q61114-1","RefSeq","NP_700467.2","14745963","A novel gene LPlunc1, a member of BPI/PLUNC gene superfamily, which is asymmetrically expressed in the developing mouse node [LPlunc1 protein]"
21792a29128,29131
> "O54803-1","RefSeq","NP_035158.2","27254077","Purinergic signaling via P2X6 is not significantly involved in the regulation of renal electrolyte handling under normal physiological conditions. Publication Status: Online-Only"
> "O54803-1","RefSeq","NP_035158.2","25874565","Once inside the nucleus, P2X6 subunit interacts with the splicing factor 3A1, which ultimately results in a reduction of the mRNA splicing activity Publication Status: Online-Only"
> "O54803-1","RefSeq","NP_035158.2","19442872","This study provides the first evidence that P2X8 receptors are expressed on LHRH-containing neurons."
> "O54803-1","RefSeq","NP_035158.2","17605080","Immunoreactivity for P2X3-, P2X5-, and P2X6-purinoceptors was observed in mouse retina."
21794a29134,29139
> "Q9ESU6-1","RefSeq","NP_932762.2","31292434","Time-series modeling of cerebellar granule cell progenitors (GCP) cell cycle exit identified downregulation of activity of the epigenetic reader protein Brd4. Brd4 binding to the Gli1 locus is controlled by casein kinase 1delta-dependent phosphorylation during GCP proliferation and decreases during GCP cell cycle exit. Publication Status: Online-Only"
> "Q9ESU6-1","RefSeq","NP_932762.2","30745801","MiR-29a negatively regulates hepatic stellate cell activation by inhibiting BRD4 and EZH2 function. Publication Status: Online-Only"
> "Q9ESU6-1","RefSeq","NP_932762.2","29662175","Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity in mouse embryonic stem cells."
> "Q9ESU6-1","RefSeq","NP_932762.2","29694891","RelA-BRD4 signaling in distal tracheobronchiolar epithelial cells mediates acute inflammation in response to luminal viral patterns."
> "Q9ESU6-1","RefSeq","NP_932762.2","12192049","Brd4 binds to replication factor C and inhibits progression to S phase"
> "Q9ESU6-1","RefSeq","NP_932762.2","11997514","Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4."
21805a29151,29152
> "P05367-1","RefSeq","NP_035444.1","26187995","SAA1/2 produced by macrophages promotes early lesion formation in the ascending aorta in LDLR knockout mice. Publication Status: Online-Only"
> "Q9WVQ0-1","RefSeq","NP_064322.1","30032984","Mutations in PMFBP1 are an important cause of infertility in men with acephalic spermatozoa syndrome."
21818a29166
> "Q69ZK5-1","RefSeq","NP_001074872.1","29939266","KLHL14 promotes B-1a development in mice"
21838a29187,29193
> "O70281-1","RefSeq","NP_038865.1","22745813","Results demonstrate the importance of protein-tyrosine sulfation for proper development of the retina and suggest different phenotypes resulting from elimination of TPST-1 or -2 may reflect differential expression patterns or levels of the enzymes."
> "O70281-1","RefSeq","NP_038865.1","21665277","Two genes identified in this analysis, PLEC1 and TPST1, reduced IL-6 production by macrophages"
> "O70281-1","RefSeq","NP_038865.1","21633705","Data show that Tpst1/Tpst2 DKO leukocytes bound less P-selectin than wild type leukocytes despite equivalent surface expression of Psgl-1."
> "O70281-1","RefSeq","NP_038865.1","21039965","These results indicate that protein-tyrosine sulfation by Tpst1/2 is essential for proper outer segment morphogenesis and synaptic function, but is not critical for overall retinal structure or synapse formation."
> "O70281-1","RefSeq","NP_038865.1","18243191","Tpst1 and Tpst2 are the only Tpst genes in mice, tyrosine sulfation is required for normal pulmonary function at birth, and TPST-2 is required for normal thyroid gland function."
> "Q99LL3-1","RefSeq","NP_067503.3","21942880","Chondroitin 4-O-sulfotransferase-2 efficiently transferred sulfate from 3'-phosphoadenosine 5'-phosphosulfate to position 4 of non-reducing terminal GalNAc-linkage residues forming chondroitin sulfate."
> "Q61532-1","RefSeq","NP_081694.1","12808096","ERK3 biological activity is regulated by its cellular abundance through the control of protein stability"
21858,21860d29212
< "Q9D6X5-1","RefSeq","NP_001158291.1","27272163","Our knowledge, this is the first report to indicate that Rfvt3 contributes to placental riboflavin transport, and that disruption of Slc52a3 gene caused neonatal mortality with hyperlipidemia and hypoglycemia owing to riboflavin deficiency. Publication Status: Online-Only"
< "Q9D6X5-1","RefSeq","NP_001158291.1","26976849","Loss of Slc52a3 gene is associated with Brown-Vialetto-van Laere syndrome."
< "Q9D6X5-1","RefSeq","NP_001158291.1","26660539","The RFVT-3 system is the main transporter involved in carrier-mediated riboflavin uptake in the native mouse small and large intestine"
21861a29214,29217
> "Q3UKC1-1","RefSeq","NP_080092.2","29476905","TAX1BP1 overexpression promoted autophagic flux, as demonstrated by increased LC3-RFP fluorescence in vitro. Furthermore, the autophagy inhibitor 3-MA abolished the protective effects of TAX1BP1 in vivo."
> "Q3UKC1-1","RefSeq","NP_080092.2","28314591","These studies reveal that TAX1BP1 drives a specialized form of autophagy, providing critical amino acids that activate mTOR and enable the metabolic transition of activated T cells."
> "Q3UKC1-1","RefSeq","NP_080092.2","27515252","These findings show that TAX1BP1 restricts ERK activation and Blimp-1 expression and regulates germinal center formation. Publication Status: Online-Only"
> "Q3UKC1-1","RefSeq","NP_080092.2","26287441","The induction of antibodies to an AQP4 epitope in mice immunized with the TAX1BP1-derived peptide suggests that a latent HTLV-1 infection could lead to TAX1BP1 antigen presentation and the production of anti-AQP4 antibodies in human neuromyelitis optica."
21863a29220,29228
> "Q8R448-1","RefSeq","NP_694754.1","18832023","Collectively, our observations suggest that otospiralin is possibly involved in signaling pathways, and could play a role in repair mechanisms subsequent to an injury in the central nervous system."
> "Q8R448-1","RefSeq","NP_694754.1","15632083","Data suggest that impairment of fibrocytes caused by the loss in otospiralin leads to abnormal cochlear physiology and auditory function."
> "B2RXV4-1","RefSeq","NP_001300676.1","27006955","Study found that primary and immortalized murine macrophages downregulate Flvcr mRNA levels upon LPS stimulation; findings point to a new role for FLVCR and heme export in macrophages responses to infection and inflammation"
> "B2RXV4-1","RefSeq","NP_001300676.1","26067085","Data shows that FLVCR1a participates in the control of intestinal mucosa homeostasis by exporting the excess of de novo synthesized heme from intestinal cells."
> "B2RXV4-1","RefSeq","NP_001300676.1","25582857","These studies identify a novel and unexpected role for FLVCR, a major facilitator superfamily metabolite transporter, in T cell development"
> "B2RXV4-1","RefSeq","NP_001300676.1","24486949","Flvcr1a maintains a free heme pool that regulates heme synthesis and degradation as well as cytochromes P450 expression and activity."
> "B2RXV4-1","RefSeq","NP_001300676.1","24021674","FLVCR is redundant in stem cells but has critical and contrasting stage-specific roles in discrete hematopoietic lineages"
> "B2RXV4-1","RefSeq","NP_001300676.1","22058337","Hemochromatosis is associated not only with excessive accumulation of free iron in the retina and retinal pigment epithelium but also with excessive accumulation of heme. Publication Status: Online-Only"
> "B2RXV4-1","RefSeq","NP_001300676.1","18258918","Data show that FLVCR exports heme & is required by erythroid progenitors to complete terminal differentiation; data show that FLVCR functions in macrophage heme-iron recycling and that systemic iron balance involves heme-iron trafficking via FLVCR"
21867,21870d29231
< "Q9CZ44-1","RefSeq","NP_001278003.1","27540115","Our data identify EBP50 as a previously unidentified regulator of Nox1 and support that it promotes Nox1 activity by binding p47(phox) This interaction is pivotal for agonist-induced smooth muscle ROS, hypertrophy, and vasoconstriction and has implications for ROS-mediated physiological and pathophysiological processes."
< "Q9CZ44-1","RefSeq","NP_001278003.1","23429921","Data suggest that NADPH oxidase-derived cytosolic superoxide is increased in islets upon oleate exposure and leads to beta cell dysfunction; whole-body NADPH oxidase inhibition (via p47 knockout) decreases superoxide and restores islet function."
< "Q9CZ44-1","RefSeq","NP_001278003.1","18403597","Genetic ablation of components of NADPH oxidase enhances susceptibility to the proinflammatory effects of CS leading to airspace enlargement and alveolar damage."
< "Q9CZ44-1","RefSeq","NP_001278003.1","14988733","That p47 ubiquitin regulatory X domain domains may act as general p97/valosin containing protein/CDC48 binding modules and that adaptor binding for N-ethylmaleimide sensitive factor and p97 might involve different binding sites"
21878a29240,29244
> "Q8K3J9-1","RefSeq","NP_671750.2","29196502","Gprc5c KO mice have altered acid-base homeostasis and reduced NHE3 activity in the kidney."
> "Q8K3J9-1","RefSeq","NP_671750.2","28228611","Data suggest that agents (such as all-trans retinoic acid) that activate Gprc5c restore and/or maintain functional insulin-secreting cells; Gprc5c appears to play role in regulation of expression of genes controlling apoptosis, cell survival, and cell proliferation in insulin-secreting cells."
> "Q8K3J9-1","RefSeq","NP_671750.2","21840300","GPRC5C does not affect behavior, though it has a high sequence similarity to GPRC5B."
> "Q810I2-1","RefSeq","NP_839971.1","29604308","TRIM50, via the RING domain, ubiquitinates Beclin 1 in a K63-dependent manner enhancing its binding with ULK1 and autophagy activity."
> "Q810I2-1","RefSeq","NP_839971.1","22872646","TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells"
21882a29249,29251
> "P59383-1","RefSeq","NP_796277.2","23701859","The spatiotemporal expression pattern of Lrrn4 contributes to the development of synaptic function in the DRG neurons."
> "P59383-1","RefSeq","NP_796277.2","23069668","Lrrn4 is expressed in a subset of nociceptive neurons and might contribute to the maintenance of nociceptive circuits."
> "P59383-1","RefSeq","NP_796277.2","15870286","Results suggest that NLRR4 plays a key role in hippocampus-dependent long-lasting memory"
21887a29257,29259
> "Q5RJY2-1","RefSeq","NP_001161436.1","18511420","G2E3 is a dual function ubiquitin ligase essential for prevention of apoptosis in early embryogenesis"
> "P30280-1","RefSeq","NP_033959.1","30674440","We advance a model of impaired endothelial regeneration during atherosclerosis, where the increase in EC miR-652-3p expression downregulates Ccnd2, thereby negatively regulating cell proliferation under hyperlipidemic stress"
> "P30280-1","RefSeq","NP_033959.1","30300583","That RUNX1/ETO maintains leukemia by promoting cell cycle progression and identifies G1 CCND-CDK complexes as promising therapeutic targets for treatment of RUNX1/ETO-driven acute myeloid leukemia Erratum:[Cancer Cell. 2019 Apr 15;35(4):705. PMID: 30991028]"
21888a29261,29262
> "O35680-1","RefSeq","NP_036015.1","19439209","NF-Y type CCAAT boxes are found preferentially in bidirectional Mrps12/Sarsm promoters, but many such promoters lack them and must be regulated in another way."
> "O35680-1","RefSeq","NP_036015.1","17179180","Identification of an array of 4 CCAAT box elements required for efficient transcription of the Mrps12 gene."
21896a29271
> "Q8BU31-1","RefSeq","NP_766001.1","28714326","Study found that SCII upregulated the expression of miR-204 and downregulated the expression of RAP2C; that hypoxia increased the expression of miR-204 and decreased the expression of RAP2C, and overexpression of RAP2C attenuates the effect of hypoxia on apoptosis rate; and miR-204 could directly bind to RAP2C, and could regulate the expression of RAP2C."
21908a29284,29295
> "P41241-1","RefSeq","NP_031809.2","30173891","The results suggest that Csk in Intestinal epithelial cells plays important roles in the regulation of the intestinal epithelial barrier function and protection against colitis."
> "P41241-1","RefSeq","NP_031809.2","29301754","This study establishes Csk and CD148 as critical molecular switches controlling the thrombotic and hemostatic capacity of platelets and reveals cell-intrinsic mechanisms that prevent pathological thrombosis from occurring."
> "P41241-1","RefSeq","NP_031809.2","28724838","Identify a physiological pathway by which blood pressure is regulated, in which the insufficiency of Csk induces aldosterone production with zonal specificity in the adrenal glands, increasing sodium reabsorption and plasma volume and thus resulting in hypertension."
> "P41241-1","RefSeq","NP_031809.2","28855588","These data suggest that inhibition of GABAergic inhibitory postsynaptic currents by morphine involves a beta-arr2/c-Src mediated mechanism. Publication Status: Online-Only"
> "Q60520-2","RefSeq","NP_035508.2","29733394","Sin3a interacted with Tet1 to facilitate the transcription of a set of their co-target genes in embryonic stem cells."
> "Q60520-2","RefSeq","NP_035508.2","29494759","These findings together suggest that SIN3A has a critical role in regulation of synaptic plasticity and might act as a potential therapeutic target to rescue memory decline during amnesia and other neuropsychiatric pathologies"
> "Q8VE91-4","RefSeq","NP_079735.2","27511895","FAM134B-dependent endoplasmic reticulum (ER)-phagy is an important limiting event in Ebola virus (EBOV) replication in mouse cells"
> "Q8VE91-4","RefSeq","NP_079735.2","26040720","Selective endoplasmic reticulum (ER)-phagy via FAM134 proteins is indispensable for mammalian cell homeostasis and controls ER morphology and turnover in mice and humans"
> "Q8VE91-4","RefSeq","NP_079735.2","19838196","Show that loss-of-function mutations in FAM134B, encoding a newly identified cis-Golgi protein, cause hereditary sensory and autonomic neuropathy type II."
> "O35309-1","RefSeq","NP_062274.1","29326438","Nmi has a distinct role in the differentiation process of mammary luminal epithelial cell compartment and developmental aberrations resulting from Nmi absence contribute to metastasis."
> "O35309-1","RefSeq","NP_062274.1","29038465","Damage-associated molecular patterns (DAMP) are important mediators of innate immunity. Here the authors show that N-myc and STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act as DAMPs to promote inflammation by activating macrophages via the Toll-like receptor 4 and NF-kappaB pathways. Publication Status: Online-Only"
> "O35309-1","RefSeq","NP_062274.1","23956435","These findings suggest that Nmi is a negative regulator of the virus-triggered induction of type I IFNs that targets IRF7"
21912a29300,29304
> "Q8C7G5-1","RefSeq","NP_536682.2","30369479","Lnc-RAP3 suppress 3T3-L1 preadipocyte differentiation by affecting the expression of the genes involved in adipogenic differentiation."
> "Q8C7G5-1","RefSeq","NP_536682.2","29530023","ApoA-V is a novel regulator of lipid metabolism in cardiomyocytes. Publication Status: Online-Only"
> "Q8C7G5-1","RefSeq","NP_536682.2","29425239","Magnolol-mediated regulation of plasma triglyceride through affecting lipoprotein lipase activity in apolipoprotein A5 knock-in mice. Publication Status: Online-Only"
> "Q8C7G5-1","RefSeq","NP_536682.2","12615678","Review. APOA5 represents a newly discovered gene involved in triglyceride metabolism in both humans and mice whose mechanism of action remains to be deciphered. Review article"
> "Q8C7G5-1","RefSeq","NP_536682.2","12135615","A role of ApoA-V in regulating levels of circulating triglycerides and cholesterol."
21914a29307
> "Q3TL54-1","RefSeq","NP_001030078.1","19703589","We identified a 5kb DNA fragment that covers upstream region of Trim43a as a putative promoter, which can drive the expression of mStrawberry fluorescent protein in a manner similar to endogenous Trim43 genes."
21918,21920d29310
< "Q8K4J0-1","RefSeq","NP_666226.2","25818648","ATM phosphorylates DNA-PKcs to recruit Artemis and promote end-processing."
< "Q8K4J0-1","RefSeq","NP_666226.2","12615897","Data show that Artemis appears to be required for a subset of nonhomologous DNA end joining reactions that require end processing [Artemis]."
< "Q8K4J0-1","RefSeq","NP_666226.2","12504013","Deficient mice have a phenotype similar to that of DNA-PKcs-deficient mice-including severe combined immunodeficiency associated with defects in opening and joining V(D)J coding hairpin ends and increased cellular ionizing radiation sensitivity (artemis)"
21926d29315
< "Q9ET47-1","RefSeq","NP_997570.1","28516904","Findings suggest that Lhx1/5, through regulating Espin protein expression, control dendritogenesis and spine morphogenesis in postnatal Purkinje cells (PCs). Publication Status: Online-Only"
21930a29320,29321
> "Q61606-1","RefSeq","NP_032127.2","29925501","Data, including data from studies using knockout mice, suggest that control of whole-body energy expenditure by Gcgr agonism requires intact Fxr signaling and Fgf21 secretion in liver. (Gcgr = glucagon receptor glucagon; Fxr = farnesoid X receptor; Fgf21 = fibroblast growth factor-21)"
> "P57776-1","RefSeq","NP_083939.1","14971650","The up-regulation of expression of TEF-1delta is a novel molecular mechanism responsible, at least in part, for cadmium carcinogenesis"
21939a29331
> "Q8BSN9-1","RefSeq","NP_081399.3","20869947","These results introduce FASTKD3 as an essential component of mitochondrial respiration that may modulate energy balance in cells exposed to adverse conditions by functionally coupling mitochondrial protein synthesis to respiration."
21947a29340
> "A2AJ77-1","RefSeq","NP_001116834.1","23856557","Prdm12 is induced by the retinoic acid signaling in vivo, and may regulate neural differentiation during animal development."
21956,21957d29348
< "Q6NWV3-1","RefSeq","NP_001161235.1","30476139","The C11ORF74, interacts with the IFT-A complex via the IFT122 subunit and is accumulated at the distal tip in the absence of an IFT-A subunit IFT139, suggesting that at least a fraction of C11ORF74 molecules can be transported towards the ciliary tip by associating with the IFT-A complex, although its majority might be out of cilia at steady state."
< "Q6NWV3-1","RefSeq","NP_001161235.1","19000668","Studies on a complex A mutant mouse, defective for the Ift122 gene, is reported."
21960,21962c29351
< "Q9D032-1","RefSeq","NP_076161.2","27236334","Ssbp3 induces differentiation of mouse embryonic stem cells into trophoblast-like cells. Publication Status: Online-Only"
< "Q9D032-1","RefSeq","NP_076161.2","26495868","SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic beta-Cell Target Genes"
< "Q9D032-1","RefSeq","NP_076161.2","15857913","Ssdp1 regulates the development of late head organizer tissues and body growth by functioning as an essential activator component of a Lim1 complex through interaction with Ldb1."
---
> "Q7TSV9-1","RefSeq","NP_938041.1","17971504","E130303B06Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia."
21972,21975c29361,29362
< "Q8BW72-1","RefSeq","NP_001155295.1","29054488","High Jmjd2a expression is associated with neuropathic pain."
< "Q8BW72-1","RefSeq","NP_001155295.1","28827393","This study dissects an important dual role for maternal Kdm4a in determining faithful early embryonic development and the implantation process."
< "Q8BW72-1","RefSeq","NP_001155295.1","28511912","We propose the inhibition of KDM4A activity as a strategy to suppress IL-6 production and attenuate colitis induction."
< "Q8BW72-1","RefSeq","NP_001155295.1","27711046","Jmjd2 class demethylases are critical epigenetic regulators involved in etiopathology of depression and related disorders."
---
> "P97384-1","RefSeq","NP_038497.2","26908448","ANXA11 level regulates lymph node metastases and 5-FU resistance of Hca-P murine hepatocarcinoma cells via c-Jun pathway"
> "P97384-1","RefSeq","NP_038497.2","25776480","This study showed that Annexin A11 knockdown inhibits the in vitro proliferation and cell apoptosis of Hca-F cell via Akt2/FoxO1 and/or MMP-9 expression pathway."
21984a29372,29376
> "P97376-1","RefSeq","NP_038550.2","27234941","FRG1 is involved in the morphogenesis of the tooth germ, as well as in the formation of enamel and dentin matrices and that FRG1 may play a role in the odontogenesis in the mouse following BMP4 stimulation."
> "P97376-1","RefSeq","NP_038550.2","25326393","Mouse Frg1 genomic area lacks DUX4 binding sites and DUX4 is unable to activate the endogenous mouse Frg1 gene providing a possible explanation for the lack of muscle phenotype in DUX4 transgenic mice."
> "P97376-1","RefSeq","NP_038550.2","24305066","On the basis of these results, it was proposed that aberrant fTnT represents a biological marker of muscle phenotype severity and disease progression."
> "P97376-1","RefSeq","NP_038550.2","23720823","This study suggests a novel role of FRG1 as epigenetic regulator of muscle differentiation and indicates that Suv4-20h1 has a gene-specific function in myogenesis."
> "P97376-1","RefSeq","NP_038550.2","23525014","Transgenic overexpression results in a muscle-growth defect and a muscle regeneration impairment"
21986a29379,29382
> "Q60654-1","RefSeq","NP_055009.5","24797174","The ectodomain of inhibitory Ly49G of the BALB/c mouse strain is highly similar to the Ly49W activating receptor in the nonobese diabetic (NOD) mouse."
> "Q3U285-1","RefSeq","NP_835278.2","25366156","These findings suggest that transactivation activities of Mlr1 and Mlr2 are differentially regulated by splicing variants of NOL4, which are expressed in a tissue-selective manner."
> "Q3U285-1","RefSeq","NP_835278.2","12560079","Identification and characterization of Mlr2 a homolog of Mblk-1, a transcription factor from the honeybee brain; expressed predominantly in the spermatocytes of the testis"
> "Q61093-1","RefSeq","NP_031833.3","23118986","A novel splice variant of NOX2 that regulates NADPH oxidase activity in macrophages"
21999a29396,29399
> "Q99NH7-1","RefSeq","NP_109652.3","31297132","Oxidative stress inhibits the expression of Prestin protein, and the transcription mechanism is triggered to compensate for the loss of Prestin protein in HEI-OC1 cells. AP-2delta is one of the important TFs that suppresses transcription of the Prestin gene, and AP-2delta suppression further boosted Prestin mRNA activation under oxidative stress. Publication Status: Online-Only"
> "Q99NH7-1","RefSeq","NP_109652.3","14553901","Although prestin is expressed in vestibular hair cells, it is unlikely that it supports the form of somatic motility observed in outer hair cells."
> "Q99NH7-1","RefSeq","NP_109652.3","12584604","Genomic characterization and expression of mouse prestin"
> "Q99NH7-1","RefSeq","NP_109652.3","12239568","Targeted deletion of prestin in mice results in loss of outer hair cell electromotility in vitro and a 40-60 dB loss of cochlear sensitivity in vivo, without disruption of mechano-electrical transduction in outer hair cells"
22004d29403
< "Q9WTU6-1","RefSeq","NP_001157143.1","29950132","The role of MAPK8/9 in autophagy may be context-dependent and more complex than previously considered."
22013,22016c29412,29414
< "Q9QYS9-1","RefSeq","NP_001152989.1","30628007","This initial screen isolated two potential Emx2-binding partner proteins, Cnot6l and QkI-7. These novel Emx2-binding proteins are involved in multiple levels of mRNA metabolism that including splicing, mRNA export, translation, and destruction"
< "Q9QYS9-1","RefSeq","NP_001152989.1","29133306","Overexpression of Qki5 strongly attenuates the toxic effect of doxorubicin via regulating cardiac circular RNAs."
< "Q9QYS9-1","RefSeq","NP_001152989.1","29021242","This study explores how levels of two isoforms, nuclear Quaking-5 (Qk5) and cytoplasmic Qk6, are regulated in mouse myoblasts. Qk5 and Qk6 proteins have distinct functions in splicing and translation, respectively, enforced through differential subcellular localization."
< "Q9QYS9-1","RefSeq","NP_001152989.1","29021239","These data collectively indicate that Qki5 regulates communication between neural stem cells by mediating numerous RNA processing events and suggest new links between splicing regulation and neural stem cell states."
---
> "P11438-1","RefSeq","NP_034814.2","29860631","By whole-mount immunofluorescence on postnatal day 3 mouse cochlea, we show its expression in outer (OHC) and inner (IHC) hair cells cytosol co-localizing with Lamp-1 in lysosomes. Furthermore, we provide evidence that the variant alters the PDE1C hydrolytic activity for both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)"
> "P11438-1","RefSeq","NP_034814.2","29749495","LIN28A inhibits lysosomeassociated membrane glycoprotein 1 protein expression in embryonic stem and bladder cancer cells."
> "P11438-1","RefSeq","NP_034814.2","30068868","Both LAMP-1 and LAMP-2 are involved in C2C12 myotube formation and LAMP-2 may contribute dominantly to it."