{
    "bcoid": "GLY_000126",
    "title": "Mouse UniProtKB Xref Reactome",
    "description": "TheMouse UniProtKB Xref Reactome contains mouse [taxid:10090] UniProtKB canonical accessions cross-referenced ...",
    "filename": "mouse_protein_xref_reactome.csv",
    "filetype": "csv",
    "categories": {
        "species": "Mus Musculus",
        "molecule": "Protein",
        "tags": "Reactome cross-references",
        "file_type": "csv",
        "status": "Reviewed",
        "scope": "internal"
    },
    "minitable": {
        "content": [
            [
                "Q9JHR7-1...",
                "R-MMU-568988..."
            ],
            [
                "Q9JHR7-1...",
                "R-MMU-903324..."
            ]
        ],
        "headers": [
            "uniprotkb_ca...",
            "database_id..."
        ],
        "colwidth": [
            "40%",
            "20%"
        ]
    },
    "sampledata": {
        "type": "table",
        "data": [
            [
                {
                    "type": "string",
                    "label": "uniprotkb_canonical_ac"
                },
                {
                    "type": "string",
                    "label": "database_id"
                },
                {
                    "type": "string",
                    "label": "database_label"
                }
            ],
            [
                "Q9JHR7-1",
                "R-MMU-5689880",
                "Ub-specific processing proteases"
            ],
            [
                "Q9JHR7-1",
                "R-MMU-9033241",
                "Peroxisomal protein import"
            ],
            [
                "B2RXV4-1",
                "R-MMU-917937",
                "Iron uptake and transport"
            ],
            [
                "E9Q3P4-1",
                "R-MMU-141444",
                "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal"
            ],
            [
                "E9Q3P4-1",
                "R-MMU-2467813",
                "Separation of Sister Chromatids"
            ],
            [
                "E9Q3P4-1",
                "R-MMU-2500257",
                "Resolution of Sister Chromatid Cohesion"
            ],
            [
                "E9Q3P4-1",
                "R-MMU-5663220",
                "RHO GTPases Activate Formins"
            ],
            [
                "E9Q3P4-1",
                "R-MMU-68877",
                "Mitotic Prometaphase"
            ],
            [
                "Q9CXG9-1",
                "R-MMU-212300",
                "PRC2 methylates histones and DNA"
            ],
            [
                "Q07968-1",
                "R-MMU-140875",
                "Common Pathway of Fibrin Clot Formation"
            ],
            [
                "Q9CXG3-1",
                "R-MMU-72163",
                "mRNA Splicing - Major Pathway"
            ],
            [
                "B1AQ89-1",
                "R-MMU-6805567",
                "Keratinization"
            ],
            [
                "B1AQ85-1",
                "R-MMU-6805567",
                "Keratinization"
            ],
            [
                "P01942-1",
                "R-MMU-2168880",
                "Scavenging of heme from plasma"
            ],
            [
                "P01942-1",
                "R-MMU-1237044",
                "Erythrocytes take up carbon dioxide and release oxygen"
            ],
            [
                "P01942-1",
                "R-MMU-1247673",
                "Erythrocytes take up oxygen and release carbon dioxide"
            ],
            [
                "P03899-1",
                "R-MMU-611105",
                "Respiratory electron transport"
            ],
            [
                "P03899-1",
                "R-MMU-6799198",
                "Complex I biogenesis"
            ],
            [
                "O35153-1",
                "R-MMU-6807878",
                "COPI-mediated anterograde transport"
            ],
            [
                "O35153-1",
                "R-MMU-6811438",
                "Intra-Golgi traffic"
            ],
            [
                "P03893-1",
                "R-MMU-611105",
                "Respiratory electron transport"
            ],
            [
                "P03893-1",
                "R-MMU-6799198",
                "Complex I biogenesis"
            ],
            [
                "Q9QYH9-1",
                "R-MMU-5668541",
                "TNFR2 non-canonical NF-kB pathway"
            ],
            [
                "Q9QYH9-1",
                "R-MMU-5676594",
                "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"
            ],
            [
                "P52479-1",
                "R-MMU-5656169",
                "Termination of translesion DNA synthesis"
            ],
            [
                "P52479-1",
                "R-MMU-5689880",
                "Ub-specific processing proteases"
            ],
            [
                "Q3SXJ3-1",
                "R-MMU-381753",
                "Olfactory Signaling Pathway"
            ],
            [
                "O08537-1",
                "R-MMU-6811558",
                "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"
            ],
            [
                "O08537-1",
                "R-MMU-383280",
                "Nuclear Receptor transcription pathway"
            ],
            [
                "O08537-1",
                "R-MMU-1257604",
                "PIP3 activates AKT signaling"
            ],
            [
                "O08537-1",
                "R-MMU-8939211",
                "ESR-mediated signaling"
            ],
            [
                "O08537-1",
                "R-MMU-9009391",
                "Non-genomic estrogen signaling"
            ],
            [
                "Q61409-1",
                "R-MMU-418555",
                "G alpha (s) signalling events"
            ],
            [
                "Q61409-1",
                "R-MMU-165160",
                "PDE3B signalling"
            ],
            [
                "A2AVK5-1",
                "R-MMU-381753",
                "Olfactory Signaling Pathway"
            ],
            [
                "Q61400-1",
                "R-MMU-1566977",
                "Fibronectin matrix formation"
            ],
            [
                "Q61400-1",
                "R-MMU-6798695",
                "Neutrophil degranulation"
            ],
            [
                "Q61400-1",
                "R-MMU-202733",
                "Cell surface interactions at the vascular wall"
            ],
            [
                "P70414-1",
                "R-MMU-425561",
                "Sodium/Calcium exchangers"
            ],
            [
                "P70414-1",
                "R-MMU-418359",
                "Reduction of cytosolic Ca++ levels"
            ],
            [
                "P70414-1",
                "R-MMU-5578775",
                "Ion homeostasis"
            ],
            [
                "P70419-1",
                "R-MMU-190372",
                "FGFR3c ligand binding and activation"
            ],
            [
                "P70419-1",
                "R-MMU-913709",
                "O-linked glycosylation of mucins"
            ],
            [
                "Q9EP78-1",
                "R-MMU-2022870",
                "Chondroitin sulfate biosynthesis"
            ],
            [
                "Q9EP73-1",
                "R-MMU-389948",
                "PD-1 signaling"
            ],
            [
                "Q9EP75-1",
                "R-MMU-211935",
                "Fatty acids"
            ],
            [
                "Q9EP75-1",
                "R-MMU-211958",
                "Miscellaneous substrates"
            ],
            [
                "Q9EP75-1",
                "R-MMU-2142691",
                "Synthesis of Leukotrienes (LT) and Eoxins (EX)"
            ],
            [
                "Q9EP75-1",
                "R-MMU-211979",
                "Eicosanoids"
            ],
            [
                "Q8R349-1",
                "R-MMU-141430",
                "Inactivation of APC/C via direct inhibition of the APC/C complex"
            ],
            [
                "Q8R349-1",
                "R-MMU-174048",
                "APC/C:Cdc20 mediated degradation of Cyclin B"
            ],
            [
                "Q8R349-1",
                "R-MMU-174084",
                "Autodegradation of Cdh1 by Cdh1:APC/C"
            ],
            [
                "Q8R349-1",
                "R-MMU-174154",
                "APC/C:Cdc20 mediated degradation of Securin"
            ],
            [
                "Q8R349-1",
                "R-MMU-174178",
                "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
            ],
            [
                "Q8R349-1",
                "R-MMU-174184",
                "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
            ],
            [
                "Q8R349-1",
                "R-MMU-176407",
                "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
            ],
            [
                "Q8R349-1",
                "R-MMU-176408",
                "Regulation of APC/C activators between G1/S and early anaphase"
            ],
            [
                "Q8R349-1",
                "R-MMU-176409",
                "APC/C:Cdc20 mediated degradation of mitotic proteins"
            ],
            [
                "Q8R349-1",
                "R-MMU-176412",
                "Phosphorylation of the APC/C"
            ],
            [
                "Q8R349-1",
                "R-MMU-179409",
                "APC-Cdc20 mediated degradation of Nek2A"
            ],
            [
                "Q8R349-1",
                "R-MMU-2559582",
                "Senescence-Associated Secretory Phenotype (SASP)"
            ],
            [
                "Q8R349-1",
                "R-MMU-2467813",
                "Separation of Sister Chromatids"
            ],
            [
                "Q8R349-1",
                "R-MMU-69017",
                "CDK-mediated phosphorylation and removal of Cdc6"
            ],
            [
                "Q8R349-1",
                "R-MMU-983168",
                "Antigen processing: Ubiquitination & Proteasome degradation"
            ],
            [
                "O08911-1",
                "R-MMU-168638",
                "NOD1/2 Signaling Pathway"
            ],
            [
                "O08911-1",
                "R-MMU-376172",
                "DSCAM interactions"
            ],
            [
                "O08911-1",
                "R-MMU-4420097",
                "VEGFA-VEGFR2 Pathway"
            ],
            [
                "O08911-1",
                "R-MMU-525793",
                "Myogenesis"
            ],
            [
                "O08912-1",
                "R-MMU-6811436",
                "COPI-independent Golgi-to-ER retrograde traffic"
            ],
            [
                "O08912-1",
                "R-MMU-913709",
                "O-linked glycosylation of mucins"
            ],
            [
                "O08915-1",
                "R-MMU-8937144",
                "Aryl hydrocarbon receptor signalling"
            ],
            [
                "O08914-1",
                "R-MMU-2142753",
                "Arachidonic acid metabolism"
            ],
            [
                "O08917-1",
                "R-MMU-8849932",
                "Synaptic adhesion-like molecules"
            ],
            [
                "Q91ZK0-1",
                "R-MMU-8866904",
                "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"
            ],
            [
                "Q91ZK0-1",
                "R-MMU-8866907",
                "Activation of the TFAP2 (AP-2) family of transcription factors"
            ],
            [
                "P19070-1",
                "R-MMU-977606",
                "Regulation of Complement cascade"
            ],
            [
                "Q8BZM0-1",
                "R-MMU-4641258",
                "Degradation of DVL"
            ],
            [
                "Q8BZM1-1",
                "R-MMU-983168",
                "Antigen processing: Ubiquitination & Proteasome degradation"
            ],
            [
                "P50429-1",
                "R-MMU-1660662",
                "Glycosphingolipid metabolism"
            ],
            [
                "P50429-1",
                "R-MMU-1663150",
                "The activation of arylsulfatases"
            ],
            [
                "P50429-1",
                "R-MMU-2024101",
                "CS/DS degradation"
            ],
            [
                "P50429-1",
                "R-MMU-6798695",
                "Neutrophil degranulation"
            ],
            [
                "Q8BTJ4-1",
                "R-MMU-6798695",
                "Neutrophil degranulation"
            ],
            [
                "Q99LV7-1",
                "R-MMU-162710",
                "Synthesis of glycosylphosphatidylinositol (GPI)"
            ]
        ]
    },
    "readme": "Name\n   - Mouse UniProtKB Xref Reactome\n\nVersion\n   - 1.4.5\n\nCreated on\n  - 2019-03-15T16:16:23.633025\n\nModified on\n   - 2019-09-12T17:31:07.690234\n\nCreated by\n   - Jeet Vora [jeetvora@gwu.edu], Rahi Navelkar [rsn13@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Xavier Holmes [xavierh@email.gwu.edu]\n\nAuthors\n   - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n   - \n\nUsability Domain\n   - TheMouse UniProtKB Xref Reactome contains mouse [taxid:10090] UniProtKB canonical accessions cross-referenced to Reactome database accessions/identifiers. REACTOME is an open-source, open access, manually curated and peer-reviewed pathway database. The dataset is derived from 2019-05 UniProt release. If you use this dataset please provide proper attribution to EMBL-EBI-UniProtKB and GlyGen\n\nDescription Domain\n   Keywords\n   - pathways\n   - reactions\n   - REACTOME\n   - cross-reference\n\n   Pipeline Steps\n   - Step-1: The script loads the UniProtKB canonical accessions that are cross-referenced to REACTOME database accessions/identifiers from the triplestore containing triples from nt file and extracts the data as a csv dataset\n\nExecution Domain\n   Scripts   - https://github.com/GW-HIVE/glygen-backend-integration/blob/master/pipeline/integrator/make-protein-dataset.py\n\n\n   Software Prerequisites\n      Name: Python\n      Version: 2.7.5\n      URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n   Input Subdomain\n      Name: uniprot-proteome-10090-mus-musculus-2019-05.nt\n      URI: https://data.glygen.org/ln2wwwdata/source/uniprot-proteome-10090-mus-musculus-2019-05.nt\n      Name: mouse_protein_idmapping.csv\n      URI: https://data.glygen.org/ln2wwwdata/reviewed/mouse_protein_idmapping.csv\n   Output Subdomain\n      Name: mouse_protein_xref_reactome.csv\n      URI: http://data.glygen.org/ln2wwwdata/reviewed/mouse_protein_xref_reactome.csv\n      Name: mouse_protein_xref_reactome.stat.csv\n      URI: http://data.glygen.org/ln2wwwdata/reviewed/mouse_protein_xref_reactome.stat.csv\n\nFields\n      Name: \"uniprotkb_canonical_ac\"\n     Description: \"Accession assigned to the protein isoform chosen to be the canonical sequence to which all positional annotation refers in UniProtKB database\"\n      Unique Values: \"9234\"\n      Name: \"database_label\"\n     Description: \"Label or name assigned to the corresponding identifier in the source database\"\n      Unique Values: \"1280\"\n      Name: \"database_id\"\n     Description: \"Identifier in the database\"\n      Unique Values: \"1280\"",
    "downloadurl": "/ln2data/releases/data/v-1.4.5/reviewed/mouse_protein_xref_reactome.csv"
}