{
    "bcoid": "GLY_000125",
    "title": "Human UniProtKB Xref Reactome",
    "description": "The Human UniProtKB Xref Reactome contains human [taxid:9606] UniProtKB canonical accessions cross-referenced ...",
    "filename": "human_protein_xref_reactome.csv",
    "filetype": "csv",
    "categories": {
        "species": "Homo Sapiens",
        "molecule": "Protein",
        "tags": "Reactome cross-references",
        "file_type": "csv",
        "status": "Reviewed",
        "scope": "internal"
    },
    "minitable": {
        "content": [
            [
                "Q8TBF5-1...",
                "R-HSA-162710..."
            ],
            [
                "Q8TBF4-1...",
                "R-HSA-72165..."
            ]
        ],
        "headers": [
            "uniprotkb_ca...",
            "database_id..."
        ],
        "colwidth": [
            "40%",
            "20%"
        ]
    },
    "sampledata": {
        "type": "table",
        "data": [
            [
                {
                    "type": "string",
                    "label": "uniprotkb_canonical_ac"
                },
                {
                    "type": "string",
                    "label": "database_id"
                },
                {
                    "type": "string",
                    "label": "database_label"
                }
            ],
            [
                "Q8TBF5-1",
                "R-HSA-162710",
                "Synthesis of glycosylphosphatidylinositol (GPI)"
            ],
            [
                "Q8TBF4-1",
                "R-HSA-72165",
                "mRNA Splicing - Minor Pathway"
            ],
            [
                "O60507-1",
                "R-HSA-156584",
                "Cytosolic sulfonation of small molecules"
            ],
            [
                "P30613-1",
                "R-HSA-163765",
                "ChREBP activates metabolic gene expression"
            ],
            [
                "P30613-1",
                "R-HSA-70171",
                "Glycolysis"
            ],
            [
                "P30613-1",
                "R-HSA-210745",
                "Regulation of gene expression in beta cells"
            ],
            [
                "Q5H9L4-1",
                "R-HSA-6804756",
                "Regulation of TP53 Activity through Phosphorylation"
            ],
            [
                "Q5H9L4-1",
                "R-HSA-674695",
                "RNA Polymerase II Pre-transcription Events"
            ],
            [
                "Q5H9L4-1",
                "R-HSA-167161",
                "HIV Transcription Initiation"
            ],
            [
                "Q5H9L4-1",
                "R-HSA-167162",
                "RNA Polymerase II HIV Promoter Escape"
            ],
            [
                "Q5H9L4-1",
                "R-HSA-167172",
                "Transcription of the HIV genome"
            ],
            [
                "Q5H9L4-1",
                "R-HSA-73776",
                "RNA Polymerase II Promoter Escape"
            ],
            [
                "Q5H9L4-1",
                "R-HSA-73779",
                "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"
            ],
            [
                "Q5H9L4-1",
                "R-HSA-75953",
                "RNA Polymerase II Transcription Initiation"
            ],
            [
                "Q5H9L4-1",
                "R-HSA-76042",
                "RNA Polymerase II Transcription Initiation And Promoter Clearance"
            ],
            [
                "P20930-1",
                "R-HSA-6809371",
                "Formation of the cornified envelope"
            ],
            [
                "P20933-1",
                "R-HSA-6798695",
                "Neutrophil degranulation"
            ],
            [
                "P20936-1",
                "R-HSA-6802949",
                "Signaling by RAS mutants"
            ],
            [
                "P20936-1",
                "R-HSA-3928662",
                "EPHB-mediated forward signaling"
            ],
            [
                "P20936-1",
                "R-HSA-5218921",
                "VEGFR2 mediated cell proliferation"
            ],
            [
                "P20936-1",
                "R-HSA-5658442",
                "Regulation of RAS by GAPs"
            ],
            [
                "P20936-1",
                "R-HSA-186763",
                "Downstream signal transduction"
            ],
            [
                "P20936-1",
                "R-HSA-8849471",
                "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"
            ],
            [
                "Q9UM21-1",
                "R-HSA-381426",
                "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"
            ],
            [
                "Q9UM21-1",
                "R-HSA-8957275",
                "Post-translational protein phosphorylation"
            ],
            [
                "Q9UM21-1",
                "R-HSA-975577",
                "N-Glycan antennae elongation"
            ],
            [
                "P83859-1",
                "R-HSA-389397",
                "Orexin and neuropeptides FF and QRFP bind to their respective receptors"
            ],
            [
                "P83859-1",
                "R-HSA-416476",
                "G alpha (q) signalling events"
            ],
            [
                "Q70EL4-1",
                "R-HSA-5656169",
                "Termination of translesion DNA synthesis"
            ],
            [
                "Q15573-1",
                "R-HSA-5250924",
                "B-WICH complex positively regulates rRNA expression"
            ],
            [
                "Q15573-1",
                "R-HSA-427413",
                "NoRC negatively regulates rRNA expression"
            ],
            [
                "Q15573-1",
                "R-HSA-73762",
                "RNA Polymerase I Transcription Initiation"
            ],
            [
                "Q15573-1",
                "R-HSA-73772",
                "RNA Polymerase I Promoter Escape"
            ],
            [
                "Q15573-1",
                "R-HSA-73863",
                "RNA Polymerase I Transcription Termination"
            ],
            [
                "Q15573-1",
                "R-HSA-427359",
                "SIRT1 negatively regulates rRNA expression"
            ],
            [
                "Q15572-1",
                "R-HSA-5250924",
                "B-WICH complex positively regulates rRNA expression"
            ],
            [
                "Q15572-1",
                "R-HSA-427413",
                "NoRC negatively regulates rRNA expression"
            ],
            [
                "Q15572-1",
                "R-HSA-73762",
                "RNA Polymerase I Transcription Initiation"
            ],
            [
                "Q15572-1",
                "R-HSA-73772",
                "RNA Polymerase I Promoter Escape"
            ],
            [
                "Q15572-1",
                "R-HSA-73863",
                "RNA Polymerase I Transcription Termination"
            ],
            [
                "Q15572-1",
                "R-HSA-427359",
                "SIRT1 negatively regulates rRNA expression"
            ],
            [
                "Q9H999-1",
                "R-HSA-196783",
                "Coenzyme A biosynthesis"
            ],
            [
                "P23919-1",
                "R-HSA-499943",
                "Interconversion of nucleotide di- and triphosphates"
            ],
            [
                "Q8NHX9-1",
                "R-HSA-2672351",
                "Stimuli-sensing channels"
            ],
            [
                "Q9NXR8-1",
                "R-HSA-3214847",
                "HATs acetylate histones"
            ],
            [
                "Q9C0H2-1",
                "R-HSA-2672351",
                "Stimuli-sensing channels"
            ],
            [
                "Q9C0H5-1",
                "R-HSA-194840",
                "Rho GTPase cycle"
            ],
            [
                "Q9C0H5-1",
                "R-HSA-428543",
                "Inactivation of CDC42 and RAC1"
            ],
            [
                "Q9NXR1-2",
                "R-HSA-2565942",
                "Regulation of PLK1 Activity at G2/M Transition"
            ],
            [
                "Q9NXR1-2",
                "R-HSA-380259",
                "Loss of Nlp from mitotic centrosomes"
            ],
            [
                "Q9NXR1-2",
                "R-HSA-380270",
                "Recruitment of mitotic centrosome proteins and complexes"
            ],
            [
                "Q9NXR1-2",
                "R-HSA-380284",
                "Loss of proteins required for interphase microtubule organization from the centrosome"
            ],
            [
                "Q9NXR1-2",
                "R-HSA-380320",
                "Recruitment of NuMA to mitotic centrosomes"
            ],
            [
                "Q9NXR1-2",
                "R-HSA-5620912",
                "Anchoring of the basal body to the plasma membrane"
            ],
            [
                "Q9NXR1-2",
                "R-HSA-8854518",
                "AURKA Activation by TPX2"
            ],
            [
                "Q9NXR1-2",
                "R-HSA-141444",
                "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal"
            ],
            [
                "Q9NXR1-2",
                "R-HSA-2467813",
                "Separation of Sister Chromatids"
            ],
            [
                "Q9NXR1-2",
                "R-HSA-2500257",
                "Resolution of Sister Chromatid Cohesion"
            ],
            [
                "Q9NXR1-2",
                "R-HSA-5663220",
                "RHO GTPases Activate Formins"
            ],
            [
                "Q9NXR1-2",
                "R-HSA-68877",
                "Mitotic Prometaphase"
            ],
            [
                "Q96J66-1",
                "R-HSA-382556",
                "ABC-family proteins mediated transport"
            ],
            [
                "O00244-1",
                "R-HSA-3299685",
                "Detoxification of Reactive Oxygen Species"
            ],
            [
                "O00244-1",
                "R-HSA-6803544",
                "Ion influx/efflux at host-pathogen interface"
            ],
            [
                "Q9UBM8-1",
                "R-HSA-975577",
                "N-Glycan antennae elongation"
            ],
            [
                "O00241-1",
                "R-HSA-6798695",
                "Neutrophil degranulation"
            ],
            [
                "O00241-1",
                "R-HSA-2172127",
                "DAP12 interactions"
            ],
            [
                "O00241-1",
                "R-HSA-391160",
                "Signal regulatory protein family interactions"
            ],
            [
                "O00716-1",
                "R-HSA-68689",
                "CDC6 association with the ORC:origin complex"
            ],
            [
                "O00716-1",
                "R-HSA-69231",
                "Cyclin D associated events in G1"
            ],
            [
                "O00716-1",
                "R-HSA-1912408",
                "Pre-NOTCH Transcription and Translation"
            ],
            [
                "O00716-1",
                "R-HSA-2559580",
                "Oxidative Stress Induced Senescence"
            ],
            [
                "O00716-1",
                "R-HSA-2559585",
                "Oncogene Induced Senescence"
            ],
            [
                "O00716-1",
                "R-HSA-68911",
                "G2 Phase"
            ],
            [
                "Q3LI54-1",
                "R-HSA-6805567",
                "Keratinization"
            ],
            [
                "Q9UBM1-1",
                "R-HSA-1483191",
                "Synthesis of PC"
            ],
            [
                "Q9UBM4-1",
                "R-HSA-1474228",
                "Degradation of the extracellular matrix"
            ],
            [
                "P24522-1",
                "R-HSA-6804114",
                "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"
            ],
            [
                "P24522-1",
                "R-HSA-9617828",
                "FOXO-mediated transcription of cell cycle genes"
            ],
            [
                "Q13835-1",
                "R-HSA-6798695",
                "Neutrophil degranulation"
            ],
            [
                "Q13835-1",
                "R-HSA-351906",
                "Apoptotic cleavage of cell adhesion  proteins"
            ],
            [
                "Q13835-1",
                "R-HSA-6805567",
                "Keratinization"
            ],
            [
                "Q13835-1",
                "R-HSA-6809371",
                "Formation of the cornified envelope"
            ],
            [
                "Q7Z3T1-1",
                "R-HSA-381753",
                "Olfactory Signaling Pathway"
            ],
            [
                "A0AVF1-1",
                "R-HSA-5620924",
                "Intraflagellar transport"
            ]
        ]
    },
    "readme": "Name\n   - Human UniProtKB Xref Reactome\n\nVersion\n   - 1.4.5\n\nCreated on\n  - 2019-03-15T16:14:06.456984\n\nModified on\n   - 2019-04-23T17:53:55.374730\n\nCreated by\n   - Jeet Vora [jeetvora@gwu.edu], Rahi Navelkar [rsn13@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Xavier Holmes [xavierh@email.gwu.edu]\n\nAuthors\n   - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n   - \n\nUsability Domain\n   - The Human UniProtKB Xref Reactome contains human [taxid:9606] UniProtKB canonical accessions cross-referenced to Reactome database accessions/identifiers. REACTOME is an open-source, open access, manually curated and peer-reviewed pathway database. The dataset is derived from 2019-05 UniProt release. If you use this dataset please provide proper attribution to EMBL-EBI-UniProtKB and GlyGen\n\nDescription Domain\n   Keywords\n   - pathways\n   - reactions\n   - REACTOME\n   - cross-reference\n\n   Pipeline Steps\n   - Step-1: The script loads the UniProtKB canonical accessions that are cross-referenced to REACTOME database accessions/identifiers from the triplestore containing triples from nt file and extracts the data as a csv dataset\n\nExecution Domain\n   Scripts   - https://github.com/GW-HIVE/glygen-backend-integration/blob/master/pipeline/integrator/make-protein-dataset.py\n\n\n   Software Prerequisites\n      Name: Python\n      Version: 2.7.5\n      URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n   Input Subdomain\n      Name: uniprot-proteome-9606-homo-sapiens-2019-05.nt\n      URI: https://data.glygen.org/ln2wwwdata/source/uniprot-proteome-9606-homo-sapiens-2019-05.nt\n   Output Subdomain\n      Name: human_protein_xref_reactome.csv\n      URI: http://data.glygen.org/ln2wwwdata/reviewed/human_protein_xref_reactome.csv\n      Name: human_protein_xref_reactome.stat.csv\n      URI: http://data.glygen.org/ln2wwwdata/reviewed/human_protein_xref_reactome.stat.csv\n\nFields\n      Name: \"uniprotkb_canonical_ac\"\n     Description: \"Accession assigned to the protein isoform chosen to be the canonical sequence to which all positional annotation refers in UniProtKB database\"\n      Unique Values: \"10697\"\n      Name: \"database_label\"\n     Description: \"Label or name assigned to the corresponding identifier in the source database\"\n      Unique Values: \"1815\"\n      Name: \"database_id\"\n     Description: \"Identifier in the database\"\n      Unique Values: \"1825\"",
    "downloadurl": "/ln2data/releases/data/v-1.4.5/reviewed/human_protein_xref_reactome.csv"
}