{
    "bcoid": "GLY_000260",
    "title": "Rat UniProtKB Xref Reactome",
    "description": "The Rat UniProtKB Xref Reactome contains rat [taxid:10116] UniProtKB canonical accessions cross-referenced ...",
    "filename": "rat_protein_xref_reactome.csv",
    "filetype": "csv",
    "categories": {
        "species": "Rattus Norvegicus",
        "molecule": "Protein",
        "tags": "Reactome cross-references",
        "file_type": "csv",
        "status": "Reviewed",
        "scope": "internal"
    },
    "minitable": {
        "content": [
            [
                "Q5RJK9-1...",
                "R-RNO-525092..."
            ],
            [
                "Q5RJK9-1...",
                "R-RNO-73762..."
            ]
        ],
        "headers": [
            "uniprotkb_ca...",
            "database_id..."
        ],
        "colwidth": [
            "40%",
            "20%"
        ]
    },
    "sampledata": {
        "type": "table",
        "data": [
            [
                {
                    "type": "string",
                    "label": "uniprotkb_canonical_ac"
                },
                {
                    "type": "string",
                    "label": "database_id"
                },
                {
                    "type": "string",
                    "label": "database_label"
                }
            ],
            [
                "Q5RJK9-1",
                "R-RNO-5250924",
                "B-WICH complex positively regulates rRNA expression"
            ],
            [
                "Q5RJK9-1",
                "R-RNO-73762",
                "RNA Polymerase I Transcription Initiation"
            ],
            [
                "Q5RJK9-1",
                "R-RNO-73772",
                "RNA Polymerase I Promoter Escape"
            ],
            [
                "Q5RJK9-1",
                "R-RNO-73863",
                "RNA Polymerase I Transcription Termination"
            ],
            [
                "Q5RJK9-1",
                "R-RNO-76061",
                "RNA Polymerase III Transcription Initiation From Type 1 Promoter"
            ],
            [
                "Q5RJK9-1",
                "R-RNO-76066",
                "RNA Polymerase III Transcription Initiation From Type 2 Promoter"
            ],
            [
                "Q5RJK9-1",
                "R-RNO-76071",
                "RNA Polymerase III Transcription Initiation From Type 3 Promoter"
            ],
            [
                "Q5RJK8-1",
                "R-RNO-77289",
                "Mitochondrial Fatty Acid Beta-Oxidation"
            ],
            [
                "D3ZG10-1",
                "R-RNO-202433",
                "Generation of second messenger molecules"
            ],
            [
                "D3ZG10-1",
                "R-RNO-2871809",
                "FCERI mediated Ca+2 mobilization"
            ],
            [
                "D3ZG10-1",
                "R-RNO-1433557",
                "Signaling by SCF-KIT"
            ],
            [
                "D3ZG10-1",
                "R-RNO-2424491",
                "DAP12 signaling"
            ],
            [
                "D3ZG10-1",
                "R-RNO-2871796",
                "FCERI mediated MAPK activation"
            ],
            [
                "D3ZG10-1",
                "R-RNO-389356",
                "CD28 co-stimulation"
            ],
            [
                "D3ZB44-1",
                "R-RNO-212436",
                "Generic Transcription Pathway"
            ],
            [
                "D3ZZY2-1",
                "R-RNO-6791226",
                "Major pathway of rRNA processing in the nucleolus and cytosol"
            ],
            [
                "P30349-1",
                "R-RNO-2142691",
                "Synthesis of Leukotrienes (LT) and Eoxins (EX)"
            ],
            [
                "P30349-1",
                "R-RNO-6798695",
                "Neutrophil degranulation"
            ],
            [
                "P30349-1",
                "R-RNO-9018896",
                "Biosynthesis of E-series 18(S)-resolvins"
            ],
            [
                "Q5RJK5-1",
                "R-RNO-73772",
                "RNA Polymerase I Promoter Escape"
            ],
            [
                "Q5RJK5-1",
                "R-RNO-8953750",
                "Transcriptional Regulation by E2F6"
            ],
            [
                "Q5RJK6-1",
                "R-RNO-1855183",
                "Synthesis of IP2, IP, and Ins in the cytosol"
            ],
            [
                "Q6MG56-1",
                "R-RNO-114608",
                "Platelet degranulation "
            ],
            [
                "A0A0G2K0H3-1",
                "R-RNO-4641262",
                "Disassembly of the destruction complex and recruitment of AXIN to the membrane"
            ],
            [
                "A0A0G2K0H3-1",
                "R-RNO-3772470",
                "Negative regulation of TCF-dependent signaling by WNT ligand antagonists"
            ],
            [
                "A0A0G2K0H3-1",
                "R-RNO-4641263",
                "Regulation of FZD by ubiquitination"
            ],
            [
                "Q5XIH0-1",
                "R-RNO-8943724",
                "Regulation of PTEN gene transcription"
            ],
            [
                "P20961-1",
                "R-RNO-3000178",
                "ECM proteoglycans"
            ],
            [
                "P20961-1",
                "R-RNO-114608",
                "Platelet degranulation "
            ],
            [
                "P20961-1",
                "R-RNO-75205",
                "Dissolution of Fibrin Clot"
            ],
            [
                "Q6MG59-1",
                "R-RNO-114604",
                "GPVI-mediated activation cascade"
            ],
            [
                "Q4KLP0-1",
                "R-RNO-389661",
                "Glyoxylate metabolism and glycine degradation"
            ],
            [
                "M0RAP5-1",
                "R-RNO-8876198",
                "RAB GEFs exchange GTP for GDP on RABs"
            ],
            [
                "M0RAP5-1",
                "R-RNO-1483248",
                "Synthesis of PIPs at the ER membrane"
            ],
            [
                "P34997-1",
                "R-RNO-380108",
                "Chemokine receptors bind chemokines"
            ],
            [
                "P34997-1",
                "R-RNO-418594",
                "G alpha (i) signalling events"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-1227986",
                "Signaling by ERBB2"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-1251985",
                "Nuclear signaling by ERBB4"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-1257604",
                "PIP3 activates AKT signaling"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-1433557",
                "Signaling by SCF-KIT"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-1433559",
                "Regulation of KIT signaling"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-177929",
                "Signaling by EGFR"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-180292",
                "GAB1 signalosome"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-186763",
                "Downstream signal transduction"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-191650",
                "Regulation of gap junction activity"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-2029481",
                "FCGR activation"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-210990",
                "PECAM1 interactions"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-354192",
                "Integrin alphaIIb beta3 signaling"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-354194",
                "GRB2:SOS provides linkage to MAPK signaling for Integrins "
            ],
            [
                "Q9WUD9-1",
                "R-RNO-372708",
                "p130Cas linkage to MAPK signaling for integrins"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-389513",
                "CTLA4 inhibitory signaling"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-3928662",
                "EPHB-mediated forward signaling"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-3928663",
                "EPHA-mediated growth cone collapse"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-3928664",
                "Ephrin signaling"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-3928665",
                "EPH-ephrin mediated repulsion of cells"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-418592",
                "ADP signalling through P2Y purinoceptor 1"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-418594",
                "G alpha (i) signalling events"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-418885",
                "DCC mediated attractive signaling"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-430116",
                "GP1b-IX-V activation signalling"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-4420097",
                "VEGFA-VEGFR2 Pathway"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-456926",
                "Thrombin signalling through proteinase activated receptors (PARs)"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-5663220",
                "RHO GTPases Activate Formins"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-5673000",
                "RAF activation"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-5674135",
                "MAP2K and MAPK activation"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-6811558",
                "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-69231",
                "Cyclin D associated events in G1"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-8853659",
                "RET signaling"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-8874081",
                "MET activates PTK2 signaling"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-8934903",
                "Receptor Mediated Mitophagy"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-8941858",
                "Regulation of RUNX3 expression and activity"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-9009391",
                "Non-genomic estrogen signaling"
            ],
            [
                "Q9WUD9-1",
                "R-RNO-9603381",
                "Activated NTRK3 signals through PI3K"
            ],
            [
                "Q925Q4-1",
                "R-RNO-375281",
                "Hormone ligand-binding receptors"
            ],
            [
                "Q925Q4-1",
                "R-RNO-418555",
                "G alpha (s) signalling events"
            ],
            [
                "P30348-1",
                "R-RNO-380108",
                "Chemokine receptors bind chemokines"
            ],
            [
                "P30348-1",
                "R-RNO-418594",
                "G alpha (i) signalling events"
            ],
            [
                "P30348-1",
                "R-RNO-6798695",
                "Neutrophil degranulation"
            ],
            [
                "Q9WUD2-1",
                "R-RNO-3295583",
                "TRP channels"
            ],
            [
                "A0A0G2JUK9-1",
                "R-RNO-381753",
                "Olfactory Signaling Pathway"
            ],
            [
                "D3ZLV0-1",
                "R-RNO-381753",
                "Olfactory Signaling Pathway"
            ],
            [
                "Q07969-1",
                "R-RNO-3000471",
                "Scavenging by Class B Receptors"
            ],
            [
                "Q07969-1",
                "R-RNO-434313",
                "Intracellular metabolism of fatty acids regulates insulin secretion"
            ],
            [
                "Q07969-1",
                "R-RNO-114608",
                "Platelet degranulation "
            ],
            [
                "Q07969-1",
                "R-RNO-5686938",
                "Regulation of TLR by endogenous ligand"
            ]
        ]
    },
    "readme": "Name\n   - Rat UniProtKB Xref Reactome\n\nVersion\n   - 1.4.5\n\nCreated on\n  - 2019-09-06T14:06:38.987144\n\nModified on\n   - \n\nCreated by\n   - Jeet Vora [jeetvora@gwu.edu], Rahi Navelkar [rsn13@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Xavier Holmes [xavierh@email.gwu.edu]\n\nAuthors\n   - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n   - \n\nUsability Domain\n   - The Rat UniProtKB Xref Reactome contains rat [taxid:10116] UniProtKB canonical accessions cross-referenced to Reactome database accessions/identifiers. REACTOME is an open-source, open access, manually curated and peer-reviewed pathway database. The dataset is derived from 2019-05 UniProt release. If you use this dataset please provide proper attribution to EMBL-EBI-UniProtKB and GlyGen\n\nDescription Domain\n   Keywords\n   - pathways\n   - reactions\n   - REACTOME\n   - cross-reference\n\n   Pipeline Steps\n   - Step-1: The script loads the UniProtKB canonical accessions that are cross-referenced to REACTOME database accessions/identifiers from the triplestore containing triples from nt file and extracts the data as a csv dataset\n\nExecution Domain\n   Scripts   - https://github.com/GW-HIVE/glygen-backend-integration/blob/master/pipeline/integrator/make-protein-dataset.py\n\n\n   Software Prerequisites\n      Name: Python\n      Version: 2.7.5\n      URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n   Input Subdomain\n      Name: uniprot-proteome-10116-rattus-norvegicus-2019-05.nt\n      URI: https://data.glygen.org/ln2data/releases/data/v-1.4.5/source/uniprot-proteome-10116-rattus-norvegicus-2019-05.nt\n      Name: rat_protein_idmapping.csv\n      URI: https://data.glygen.org/ln2data/releases/data/v-1.4.5/reviewed/rat_protein_idmapping.csv\n   Output Subdomain\n      Name: rat_protein_xref_reactome.csv\n      URI: http://data.glygen.org/ln2data/releases/data/v-1.4.5/reviewed/rat_protein_xref_reactome.csv\n      Name: rat_protein_xref_reactome.stat.csv\n      URI: http://data.glygen.org/ln2data/releases/data/v-1.4.5/reviewed/rat_protein_xref_reactome.stat.csv\n\nFields\n      Name: \"uniprotkb_canonical_ac\"\n     Description: \"Accession assigned to the protein isoform chosen to be the canonical sequence to which all positional annotation refers in UniProtKB database\"\n      Unique Values: \"8624\"\n      Name: \"database_label\"\n     Description: \"Label or name assigned to the corresponding identifier in the source database\"\n      Unique Values: \"1269\"\n      Name: \"database_id\"\n     Description: \"Identifier in the database\"\n      Unique Values: \"1269\"",
    "downloadurl": "/ln2data/releases/data/v-1.4.5/reviewed/rat_protein_xref_reactome.csv"
}