{ "bcoid": "GLY_000625", "title": "Human Protein Cancer Biomarkers (Biomarker Portal)", "description": "This is a Human Protein Cancer Biomarkers dataset. It contains human [taxonomy:9606] cancer biomarker ...", "filename": "human_protein_biomarkers_cancer.csv", "filetype": "csv", "categories": { "species": "Homo sapiens", "molecule": "Protein", "tags": "Cancer Biomarker (BiomarkerDB)", "file_type": "csv", "status": "Reviewed", "scope": "internal" }, "minitable": { "content": [ [ "P05231-1...", "A0001..." ], [ "P05231-1...", "A0001..." ] ], "headers": [ "uniprotkb_ca...", "biomarker_id..." ], "colwidth": [ "40%", "20%" ] }, "sampledata": { "type": "table", "data": [ [ { "type": "string", "label": "uniprotkb_canonical_ac" }, { "type": "string", "label": "biomarker_id" }, { "type": "string", "label": "assessed_biomarker_entity" }, { "type": "string", "label": "biomarker" }, { "type": "string", "label": "best_biomarker_type" }, { "type": "string", "label": "loinc_code" }, { "type": "string", "label": "notes" }, { "type": "string", "label": "anatomical_entity" }, { "type": "string", "label": "uberon_id" }, { "type": "string", "label": "do_id" }, { "type": "string", "label": "do_name" }, { "type": "string", "label": "xref_key" }, { "type": "string", "label": "xref_id" }, { "type": "string", "label": "src_xref_key" }, { "type": "string", "label": "src_xref_id" } ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "", "DOID:10283 / prostate cancer", "0000178", "10283", "DOID:10283 / prostate cancer", "protein_xref_pubmed", "10914713", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "", "DOID:10283 / prostate cancer", "0000178", "10283", "DOID:10283 / prostate cancer", "protein_xref_biomarkerdb", "A0001", "protein_xref_biomarkerdb", "A0001" ], [ "P0DJI8-1", "A0016", "Serum amyloid A protein (SAA1)", "increased SAA1 level", "prognostic", "48498-0", "", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_pubmed", "20502455", "protein_xref_biomarkerdb", "A0016" ], [ "P0DJI8-1", "A0016", "Serum amyloid A protein (SAA1)", "increased SAA1 level", "prognostic", "48498-0", "", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_biomarkerdb", "A0016", "protein_xref_biomarkerdb", "A0016" ], [ "P0DJI8-1", "A0016", "Serum amyloid A protein (SAA1)", "increased SAA1 level", "monitoring", "48498-0", "", "DOID:1793 / pancreatic cancer", "0000178", "1793", "DOID:1793 / pancreatic cancer", "protein_xref_pubmed", "16211233", "protein_xref_biomarkerdb", "A0016" ], [ "P0DJI8-1", "A0016", "Serum amyloid A protein (SAA1)", "increased SAA1 level", "monitoring", "48498-0", "", "DOID:1793 / pancreatic cancer", "0000178", "1793", "DOID:1793 / pancreatic cancer", "protein_xref_biomarkerdb", "A0016", "protein_xref_biomarkerdb", "A0016" ], [ "P0DJI8-1", "A0016", "Serum amyloid A protein (SAA1)", "increased SAA1 level", "monitoring", "48498-0", "High level expression of SAA gene", "DOID:363 / uterine cancer", "0000178", "363", "DOID:363 / uterine cancer", "protein_xref_pubmed", "19536090", "protein_xref_biomarkerdb", "A0016" ], [ "P0DJI8-1", "A0016", "Serum amyloid A protein (SAA1)", "increased SAA1 level", "monitoring", "48498-0", "High level expression of SAA gene", "DOID:363 / uterine cancer", "0000178", "363", "DOID:363 / uterine cancer", "protein_xref_biomarkerdb", "A0016", "protein_xref_biomarkerdb", "A0016" ], [ "P01375-1", "A0028", "Tumor necrosis factor alpha (TNF)", "increased TNF level", "prognostic", "3074-2", "", "DOID:11934 / head and neck cancer", "0000178", "11934", "DOID:11934 / head and neck cancer", "protein_xref_pubmed", "32479790", "protein_xref_biomarkerdb", "A0028" ], [ "P01375-1", "A0028", "Tumor necrosis factor alpha (TNF)", "increased TNF level", "prognostic", "3074-2", "", "DOID:11934 / head and neck cancer", "0000178", "11934", "DOID:11934 / head and neck cancer", "protein_xref_biomarkerdb", "A0028", "protein_xref_biomarkerdb", "A0028" ], [ "P01375-1", "A0028", "Tumor necrosis factor alpha (TNF)", "increased TNF level", "prognostic", "3074-2", "", "DOID:11934 / head and neck cancer", "0000178", "11934", "DOID:11934 / head and neck cancer", "protein_xref_pubmed", "24481866", "protein_xref_biomarkerdb", "A0028" ], [ "P01375-1", "A0028", "Tumor necrosis factor alpha (TNF)", "increased TNF level", "prognostic", "3074-2", "", "DOID:11934 / head and neck cancer", "0000178", "11934", "DOID:11934 / head and neck cancer", "protein_xref_biomarkerdb", "A0028", "protein_xref_biomarkerdb", "A0028" ], [ "O15393-1", "A0030", "Transmembrane protease serine 2 (TMPRSS2)", "increased TMPRSS2 level", "prognostic", "NA", "Measured in serum (UN: 0001977) as well; increased expression of TMPRSS2", "DOID:10283 / prostate cancer", "0000178", "10283", "DOID:10283 / prostate cancer", "protein_xref_pubmed", "32660890", "protein_xref_biomarkerdb", "A0030" ], [ "O15393-1", "A0030", "Transmembrane protease serine 2 (TMPRSS2)", "increased TMPRSS2 level", "prognostic", "NA", "Measured in serum (UN: 0001977) as well; increased expression of TMPRSS2", "DOID:10283 / prostate cancer", "0000178", "10283", "DOID:10283 / prostate cancer", "protein_xref_biomarkerdb", "A0030", "protein_xref_biomarkerdb", "A0030" ], [ "Q9BYF1-1", "A0031", "Angiotensin-converting enzyme 2 (ACE2)", "increased ACE2 level", "prognostic", "NA", "Increased ACE2 expression", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_pubmed", "19212105", "protein_xref_biomarkerdb", "A0031" ], [ "Q9BYF1-1", "A0031", "Angiotensin-converting enzyme 2 (ACE2)", "increased ACE2 level", "prognostic", "NA", "Increased ACE2 expression", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_biomarkerdb", "A0031", "protein_xref_biomarkerdb", "A0031" ], [ "Q9BYF1-1", "A0031", "Angiotensin-converting enzyme 2 (ACE2)", "increased ACE2 level", "prognostic", "NA", "Increased ACE2 expression", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_pubmed", "32916258", "protein_xref_biomarkerdb", "A0031" ], [ "Q9BYF1-1", "A0031", "Angiotensin-converting enzyme 2 (ACE2)", "increased ACE2 level", "prognostic", "NA", "Increased ACE2 expression", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_biomarkerdb", "A0031", "protein_xref_biomarkerdb", "A0031" ], [ "Q14508-1", "A0032", "WAP four-disulfide core domain protein 2 (WFDC2)", "increased WFDC2 level", "prognostic", "55180-4", "Measured in serum (UN: 0001977) as well. Synonym: Human epididymis protein 4 (HE4)", "DOID:2394 / ovarian cancer", "0000178", "2394", "DOID:2394 / ovarian cancer", "protein_xref_pubmed", "21633297", "protein_xref_biomarkerdb", "A0032" ], [ "Q14508-1", "A0032", "WAP four-disulfide core domain protein 2 (WFDC2)", "increased WFDC2 level", "prognostic", "55180-4", "Measured in serum (UN: 0001977) as well. Synonym: Human epididymis protein 4 (HE4)", "DOID:2394 / ovarian cancer", "0000178", "2394", "DOID:2394 / ovarian cancer", "protein_xref_biomarkerdb", "A0032", "protein_xref_biomarkerdb", "A0032" ], [ "Q14508-1", "A0032", "WAP four-disulfide core domain protein 2 (WFDC2)", "increased WFDC2 level", "prognostic", "55180-4", "Measured in serum (UN: 0001977) as well. Synonym: Human epididymis protein 4 (HE4)", "DOID:2394 / ovarian cancer", "0000178", "2394", "DOID:2394 / ovarian cancer", "protein_xref_pubmed", "19732003", "protein_xref_biomarkerdb", "A0032" ], [ "Q14508-1", "A0032", "WAP four-disulfide core domain protein 2 (WFDC2)", "increased WFDC2 level", "prognostic", "55180-4", "Measured in serum (UN: 0001977) as well. Synonym: Human epididymis protein 4 (HE4)", "DOID:2394 / ovarian cancer", "0000178", "2394", "DOID:2394 / ovarian cancer", "protein_xref_biomarkerdb", "A0032", "protein_xref_biomarkerdb", "A0032" ], [ "Q14508-1", "A0032", "WAP four-disulfide core domain protein 2 (WFDC2)", "increased WFDC2 level", "diagnostic", "55180-4", "", "DOID:1612 / breast cancer", "0000178", "1612", "DOID:1612 / breast cancer", "protein_xref_pubmed", "27446579", "protein_xref_biomarkerdb", "A0032" ], [ "Q14508-1", "A0032", "WAP four-disulfide core domain protein 2 (WFDC2)", "increased WFDC2 level", "diagnostic", "55180-4", "", "DOID:1612 / breast cancer", "0000178", "1612", "DOID:1612 / breast cancer", "protein_xref_biomarkerdb", "A0032", "protein_xref_biomarkerdb", "A0032" ], [ "P08727-1", "A0033", "Cytokeratin-19 fragment (KRT19)", "increased KRT19 level", "prognostic", "NA", "Measured in serum (UN: 0001977) as well.", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_pubmed", "16033098", "protein_xref_biomarkerdb", "A0033" ], [ "P08727-1", "A0033", "Cytokeratin-19 fragment (KRT19)", "increased KRT19 level", "prognostic", "NA", "Measured in serum (UN: 0001977) as well.", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_biomarkerdb", "A0033", "protein_xref_biomarkerdb", "A0033" ], [ "P08727-1", "A0033", "Cytokeratin-19 fragment (KRT19)", "increased KRT19 level", "prognostic", "NA", "Measured in serum (UN: 0001977) as well.", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_pubmed", "32347972", "protein_xref_biomarkerdb", "A0033" ], [ "P08727-1", "A0033", "Cytokeratin-19 fragment (KRT19)", "increased KRT19 level", "prognostic", "NA", "Measured in serum (UN: 0001977) as well.", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_biomarkerdb", "A0033", "protein_xref_biomarkerdb", "A0033" ], [ "P08727-1", "A0033", "Cytokeratin-19 fragment (KRT19)", "increased KRT19 level", "prognostic", "NA", "Non-small cell lung cancer (NSCLC) lung non-small cell carcinoma (DOID:3908)", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_pubmed", "7541742", "protein_xref_biomarkerdb", "A0033" ], [ "P08727-1", "A0033", "Cytokeratin-19 fragment (KRT19)", "increased KRT19 level", "prognostic", "NA", "Non-small cell lung cancer (NSCLC) lung non-small cell carcinoma (DOID:3908)", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_biomarkerdb", "A0033", "protein_xref_biomarkerdb", "A0033" ], [ "P08727-1", "A0033", "Cytokeratin-19 fragment (KRT19)", "increased KRT19 level", "diagnostic", "NA", "EDRN biomarker. CYFRA21-1 level can be detected in serum (UN: 0001977) as well", "DOID:11054 / urinary bladder cancer", "0001088", "11054", "DOID:11054 / urinary bladder cancer", "protein_xref_pubmed", "25966163", "protein_xref_biomarkerdb", "A0033" ], [ "P08727-1", "A0033", "Cytokeratin-19 fragment (KRT19)", "increased KRT19 level", "diagnostic", "NA", "EDRN biomarker. CYFRA21-1 level can be detected in serum (UN: 0001977) as well", "DOID:11054 / urinary bladder cancer", "0001088", "11054", "DOID:11054 / urinary bladder cancer", "protein_xref_biomarkerdb", "A0033", "protein_xref_biomarkerdb", "A0033" ], [ "P06731-1", "A0034", "Carcinoembryonic antigen (CEACAM5)", "decreased CEACAM5 level", "prognostic", "19166-8", "Primary breast cancer", "DOID:1612 / breast cancer", "0000178", "1612", "DOID:1612 / breast cancer", "protein_xref_pubmed", "11953875", "protein_xref_biomarkerdb", "A0034" ], [ "P06731-1", "A0034", "Carcinoembryonic antigen (CEACAM5)", "decreased CEACAM5 level", "prognostic", "19166-8", "Primary breast cancer", "DOID:1612 / breast cancer", "0000178", "1612", "DOID:1612 / breast cancer", "protein_xref_biomarkerdb", "A0034", "protein_xref_biomarkerdb", "A0034" ], [ "P06731-1", "A0034", "Carcinoembryonic antigen (CEACAM5)", "increased CEACAM5 level", "diagnostic", "19166-8", "", "DOID:9256 / colorectal cancer", "0000178", "9256", "DOID:9256 / colorectal cancer", "protein_xref_pubmed", "12174919", "protein_xref_biomarkerdb", "A0034" ], [ "P06731-1", "A0034", "Carcinoembryonic antigen (CEACAM5)", "increased CEACAM5 level", "diagnostic", "19166-8", "", "DOID:9256 / colorectal cancer", "0000178", "9256", "DOID:9256 / colorectal cancer", "protein_xref_biomarkerdb", "A0034", "protein_xref_biomarkerdb", "A0034" ], [ "P06731-1", "A0034", "Carcinoembryonic antigen (CEACAM5)", "increased CEACAM5 level", "prognostic", "96044-3", "EDRN biomarker; elevated serum HE4", "DOID:2394 / ovarian cancer", "0000178", "2394", "DOID:2394 / ovarian cancer", "protein_xref_pubmed", "21683503", "protein_xref_biomarkerdb", "A0034" ], [ "P06731-1", "A0034", "Carcinoembryonic antigen (CEACAM5)", "increased CEACAM5 level", "prognostic", "96044-3", "EDRN biomarker; elevated serum HE4", "DOID:2394 / ovarian cancer", "0000178", "2394", "DOID:2394 / ovarian cancer", "protein_xref_biomarkerdb", "A0034", "protein_xref_biomarkerdb", "A0034" ], [ "Q8WXI7-1", "A0035", "Mucin-16 (MUC16)", "increased MUC16 level", "predictive", "10334-1", "", "DOID:363 / uterine cancer", "0000995", "363", "DOID:363 / uterine cancer", "protein_xref_pubmed", "29958235", "protein_xref_biomarkerdb", "A0035" ], [ "Q8WXI7-1", "A0035", "Mucin-16 (MUC16)", "increased MUC16 level", "predictive", "10334-1", "", "DOID:363 / uterine cancer", "0000995", "363", "DOID:363 / uterine cancer", "protein_xref_biomarkerdb", "A0035", "protein_xref_biomarkerdb", "A0035" ], [ "P15941-1", "A0036", "Mucin-1 (MUC1)", "increased MUC1 level", "prognostic", "2007-3", "Synomym: Cancer antigen 15-3 (CA15-3)", "DOID:1612 / breast cancer", "0000178", "1612", "DOID:1612 / breast cancer", "protein_xref_pubmed", "24674678", "protein_xref_biomarkerdb", "A0036" ], [ "P15941-1", "A0036", "Mucin-1 (MUC1)", "increased MUC1 level", "prognostic", "2007-3", "Synomym: Cancer antigen 15-3 (CA15-3)", "DOID:1612 / breast cancer", "0000178", "1612", "DOID:1612 / breast cancer", "protein_xref_biomarkerdb", "A0036", "protein_xref_biomarkerdb", "A0036" ], [ "P01579-1", "A0041", "Interferon gamma (IFNG)", "increased IFNG level", "prognostic", "12729-0", "Increased IFNG expression", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_pubmed", "29716923", "protein_xref_biomarkerdb", "A0041" ], [ "P01579-1", "A0041", "Interferon gamma (IFNG)", "increased IFNG level", "prognostic", "12729-0", "Increased IFNG expression", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_biomarkerdb", "A0041", "protein_xref_biomarkerdb", "A0041" ], [ "P09919-1", "A0043", "Granulocyte colony-stimulating factor (CSF3)", "increased CSF3 level", "prognostic", "54458-5", "Measured in plasma (UN: 0001969) as well; increased levels of G-CSF and white blood cells", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_pubmed", "21431281", "protein_xref_biomarkerdb", "A0043" ], [ "P09919-1", "A0043", "Granulocyte colony-stimulating factor (CSF3)", "increased CSF3 level", "prognostic", "54458-5", "Measured in plasma (UN: 0001969) as well; increased levels of G-CSF and white blood cells", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_biomarkerdb", "A0043", "protein_xref_biomarkerdb", "A0043" ], [ "P22301-1", "A0046", "Interleukin-10 (IL10)", "increased IL10 level", "prognostic", "26848-2", "Measured in serum (UN: 0001977) as well.", "DOID:1793 / pancreatic cancer", "0000178", "1793", "DOID:1793 / pancreatic cancer", "protein_xref_pubmed", "30304975", "protein_xref_biomarkerdb", "A0046" ], [ "P22301-1", "A0046", "Interleukin-10 (IL10)", "increased IL10 level", "prognostic", "26848-2", "Measured in serum (UN: 0001977) as well.", "DOID:1793 / pancreatic cancer", "0000178", "1793", "DOID:1793 / pancreatic cancer", "protein_xref_biomarkerdb", "A0046", "protein_xref_biomarkerdb", "A0046" ], [ "P09603-1", "A0086", "Macrophage colony-stimulating factor 1 (CSF1)", "increased CSF1 level", "diagnostic", "NA", "EDRN biomarker", "DOID:1612 / breast cancer", "0000178", "1612", "DOID:1612 / breast cancer", "protein_xref_pubmed", "23688065", "protein_xref_biomarkerdb", "A0086" ], [ "P09603-1", "A0086", "Macrophage colony-stimulating factor 1 (CSF1)", "increased CSF1 level", "diagnostic", "NA", "EDRN biomarker", "DOID:1612 / breast cancer", "0000178", "1612", "DOID:1612 / breast cancer", "protein_xref_biomarkerdb", "A0086", "protein_xref_biomarkerdb", "A0086" ], [ "P09104-1", "A0097", "Neuron-specific enolase (ENO2)", "increased ENO2 level", "prognostic", "19193-2", "Measured in serum (UN: 0001977) as well.", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_pubmed", "32347972", "protein_xref_biomarkerdb", "A0097" ], [ "P09104-1", "A0097", "Neuron-specific enolase (ENO2)", "increased ENO2 level", "prognostic", "19193-2", "Measured in serum (UN: 0001977) as well.", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_biomarkerdb", "A0097", "protein_xref_biomarkerdb", "A0097" ], [ "P09104-1", "A0097", "Neuron-specific enolase (ENO2)", "increased ENO2 level", "prognostic", "19193-2", "Measured in serum (UN: 0001977) as well.", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_pubmed", "16033098", "protein_xref_biomarkerdb", "A0097" ], [ "P09104-1", "A0097", "Neuron-specific enolase (ENO2)", "increased ENO2 level", "prognostic", "19193-2", "Measured in serum (UN: 0001977) as well.", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_biomarkerdb", "A0097", "protein_xref_biomarkerdb", "A0097" ], [ "P09104-1", "A0097", "Neuron-specific enolase (ENO2)", "increased ENO2 level", "prognostic", "19193-2", "Measured in serum (UN: 0001977) as well.", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_pubmed", "32504736", "protein_xref_biomarkerdb", "A0097" ], [ "P09104-1", "A0097", "Neuron-specific enolase (ENO2)", "increased ENO2 level", "prognostic", "19193-2", "Measured in serum (UN: 0001977) as well.", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_biomarkerdb", "A0097", "protein_xref_biomarkerdb", "A0097" ], [ "P09104-1", "A0097", "Neuron-specific enolase (ENO2)", "increased ENO2 level", "prognostic", "19193-2", "", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_pubmed", "16062024", "protein_xref_biomarkerdb", "A0097" ], [ "P09104-1", "A0097", "Neuron-specific enolase (ENO2)", "increased ENO2 level", "prognostic", "19193-2", "", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_biomarkerdb", "A0097", "protein_xref_biomarkerdb", "A0097" ], [ "P29965-1", "A0119", "CD40 ligand (CD40LG)", "increased CD40LG level", "prognostic", "NA", "", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_pubmed", "14760083", "protein_xref_biomarkerdb", "A0119" ], [ "P29965-1", "A0119", "CD40 ligand (CD40LG)", "increased CD40LG level", "prognostic", "NA", "", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_biomarkerdb", "A0119", "protein_xref_biomarkerdb", "A0119" ], [ "P29965-1", "A0119", "CD40 ligand (CD40LG)", "increased CD40LG level", "prognostic", "NA", "It was found to be a prognostic and diagnostic biomarker for pancreatic ductal adenocarcinoma (DOID:3498)", "DOID:1793 / pancreatic cancer", "0000178", "1793", "DOID:1793 / pancreatic cancer", "protein_xref_pubmed", "24745825", "protein_xref_biomarkerdb", "A0119" ], [ "P29965-1", "A0119", "CD40 ligand (CD40LG)", "increased CD40LG level", "prognostic", "NA", "It was found to be a prognostic and diagnostic biomarker for pancreatic ductal adenocarcinoma (DOID:3498)", "DOID:1793 / pancreatic cancer", "0000178", "1793", "DOID:1793 / pancreatic cancer", "protein_xref_biomarkerdb", "A0119", "protein_xref_biomarkerdb", "A0119" ], [ "P07204-1", "A0120", "Thrombomodulin (THBD)", "increased THBD level", "prognostic", "NA", "", "DOID:3571 / liver cancer", "0000178", "3571", "DOID:3571 / liver cancer", "protein_xref_pubmed", "11570577", "protein_xref_biomarkerdb", "A0120" ], [ "P07204-1", "A0120", "Thrombomodulin (THBD)", "increased THBD level", "prognostic", "NA", "", "DOID:3571 / liver cancer", "0000178", "3571", "DOID:3571 / liver cancer", "protein_xref_biomarkerdb", "A0120", "protein_xref_biomarkerdb", "A0120" ], [ "P07204-1", "A0120", "Thrombomodulin (THBD)", "decreased THBD level", "prognostic", "NA", "Silencing of TM expression", "DOID:2394 / ovarian cancer", "0000178", "2394", "DOID:2394 / ovarian cancer", "protein_xref_pubmed", "23918310", "protein_xref_biomarkerdb", "A0120" ], [ "P07204-1", "A0120", "Thrombomodulin (THBD)", "decreased THBD level", "prognostic", "NA", "Silencing of TM expression", "DOID:2394 / ovarian cancer", "0000178", "2394", "DOID:2394 / ovarian cancer", "protein_xref_biomarkerdb", "A0120", "protein_xref_biomarkerdb", "A0120" ], [ "P05305-1", "A0121", "Endothelin-1 (EDN1)", "increased EDN1 level", "diagnostic", "NA", "", "DOID:11934 / head and neck cancer", "0006914", "11934", "DOID:11934 / head and neck cancer", "protein_xref_pubmed", "26537720", "protein_xref_biomarkerdb", "A0121" ], [ "P05305-1", "A0121", "Endothelin-1 (EDN1)", "increased EDN1 level", "diagnostic", "NA", "", "DOID:11934 / head and neck cancer", "0006914", "11934", "DOID:11934 / head and neck cancer", "protein_xref_biomarkerdb", "A0121", "protein_xref_biomarkerdb", "A0121" ], [ "P16860-1", "A0125", "N-terminal pro-brain natriuretic peptide (NPPB)", "increased NPPB level", "risk", "71425-3", "", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_pubmed", "20837460", "protein_xref_biomarkerdb", "A0125" ], [ "P16860-1", "A0125", "N-terminal pro-brain natriuretic peptide (NPPB)", "increased NPPB level", "risk", "71425-3", "", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_biomarkerdb", "A0125", "protein_xref_biomarkerdb", "A0125" ], [ "P00533-1", "A0152", "Epidermal growth factor receptor (EGFR)", "presence of EGFR mutation L858R", "diagnostic", "13659-8", "EDRN biomarker. FDA approved for lung cancer; alternate LOINC ID: 14050-9, Epidermal growth factor receptor [Moles/mass] in Tissue", "DOID:1324 / lung cancer", "0002048", "1324", "DOID:1324 / lung cancer", "protein_xref_pubmed", "23599147", "protein_xref_biomarkerdb", "A0152" ], [ "P00533-1", "A0152", "Epidermal growth factor receptor (EGFR)", "presence of EGFR mutation L858R", "diagnostic", "13659-8", "EDRN biomarker. FDA approved for lung cancer; alternate LOINC ID: 14050-9, Epidermal growth factor receptor [Moles/mass] in Tissue", "DOID:1324 / lung cancer", "0002048", "1324", "DOID:1324 / lung cancer", "protein_xref_biomarkerdb", "A0152", "protein_xref_biomarkerdb", "A0152" ], [ "P00533-1", "A0152", "Epidermal growth factor receptor (EGFR)", "increased EGFR level", "prognostic", "13659-8", "EDRN biomarker - EGFR is also associated with various other cancers, most notably due to mutations that result in increased protein expression; Also a predictive biomarker; increased expression of Epidermal growth factor receptor (EGFR); alternate LOINC ID: 14050-9, Epidermal growth factor receptor [Moles/mass] in Tissue", "DOID:1612 / breast cancer", "0000310", "1612", "DOID:1612 / breast cancer", "protein_xref_pubmed", "30431376", "protein_xref_biomarkerdb", "A0152" ], [ "P00533-1", "A0152", "Epidermal growth factor receptor (EGFR)", "increased EGFR level", "prognostic", "13659-8", "EDRN biomarker - EGFR is also associated with various other cancers, most notably due to mutations that result in increased protein expression; Also a predictive biomarker; increased expression of Epidermal growth factor receptor (EGFR); alternate LOINC ID: 14050-9, Epidermal growth factor receptor [Moles/mass] in Tissue", "DOID:1612 / breast cancer", "0000310", "1612", "DOID:1612 / breast cancer", "protein_xref_biomarkerdb", "A0152", "protein_xref_biomarkerdb", "A0152" ], [ "P00533-1", "A0152", "Epidermal growth factor receptor (EGFR)", "increased EGFR level", "prognostic", "13659-8", "FDA and EDRN biomarker; overexpression of EGFR; alternate LOINC ID: 14050-9, Epidermal growth factor receptor [Moles/mass] in Tissue", "DOID:10534 / stomach cancer", "0000945", "10534", "DOID:10534 / stomach cancer", "protein_xref_pubmed", "18397279", "protein_xref_biomarkerdb", "A0152" ], [ "P00533-1", "A0152", "Epidermal growth factor receptor (EGFR)", "increased EGFR level", "prognostic", "13659-8", "FDA and EDRN biomarker; overexpression of EGFR; alternate LOINC ID: 14050-9, Epidermal growth factor receptor [Moles/mass] in Tissue", "DOID:10534 / stomach cancer", "0000945", "10534", "DOID:10534 / stomach cancer", "protein_xref_biomarkerdb", "A0152", "protein_xref_biomarkerdb", "A0152" ], [ "P00738-1", "A0153", "Haptoglobin (HP)", "increased HP level", "diagnostic", "4542-7", "Lung adenocarcinoma", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_pubmed", "27648369", "protein_xref_biomarkerdb", "A0153" ], [ "P00738-1", "A0153", "Haptoglobin (HP)", "increased HP level", "diagnostic", "4542-7", "Lung adenocarcinoma", "DOID:1324 / lung cancer", "0000178", "1324", "DOID:1324 / lung cancer", "protein_xref_biomarkerdb", "A0153", "protein_xref_biomarkerdb", "A0153" ], [ "Q13740-1", "A0154", "Activated leukocyte cell adhesion molecule (ALCAM)", "increased ALCAM level", "prognostic", "NA", "Also associated with lymph node metastasis (UN:0000029); high ALCAM expression", "DOID:4159 / skin cancer", "0001003", "4159", "DOID:4159 / skin cancer", "protein_xref_pubmed", "26134500", "protein_xref_biomarkerdb", "A0154" ], [ "Q13740-1", "A0154", "Activated leukocyte cell adhesion molecule (ALCAM)", "increased ALCAM level", "prognostic", "NA", "Also associated with lymph node metastasis (UN:0000029); high ALCAM expression", "DOID:4159 / skin cancer", "0001003", "4159", "DOID:4159 / skin cancer", "protein_xref_biomarkerdb", "A0154", "protein_xref_biomarkerdb", "A0154" ], [ "Q9HCU9-1", "A0155", "Breast cancer metastasis suppressor 1 (BRMS1)", "decreased BRMS1 level", "prognostic", "NA", "Specimen type also unspecified metastatic tissues. Also associated with several metastases breast tissue (UN:0000310) ovary tissue (UN:0000992); decreased BRMS1 Expression", "DOID:4159 / skin cancer", "0001003", "4159", "DOID:4159 / skin cancer", "protein_xref_pubmed", "20935672", "protein_xref_biomarkerdb", "A0155" ], [ "Q9HCU9-1", "A0155", "Breast cancer metastasis suppressor 1 (BRMS1)", "decreased BRMS1 level", "prognostic", "NA", "Specimen type also unspecified metastatic tissues. Also associated with several metastases breast tissue (UN:0000310) ovary tissue (UN:0000992); decreased BRMS1 Expression", "DOID:4159 / skin cancer", "0001003", "4159", "DOID:4159 / skin cancer", "protein_xref_biomarkerdb", "A0155", "protein_xref_biomarkerdb", "A0155" ], [ "P24530-1", "A0157", "Endothelin receptor type B (EDNRB)", "decreased EDNRB level", "prognostic", "NA", "", "DOID:1612 / breast cancer", "0000310", "1612", "DOID:1612 / breast cancer", "protein_xref_pubmed", "32934717", "protein_xref_biomarkerdb", "A0157" ], [ "P24530-1", "A0157", "Endothelin receptor type B (EDNRB)", "decreased EDNRB level", "prognostic", "NA", "", "DOID:1612 / breast cancer", "0000310", "1612", "DOID:1612 / breast cancer", "protein_xref_biomarkerdb", "A0157", "protein_xref_biomarkerdb", "A0157" ] ] }, "readme": "Name\n - Human Protein Cancer Biomarkers (Biomarker Portal)\n\nVersion\n - 1.11.2\n\nCreated on\n - 2022-03-29T11:06:26.279356\n\nModified on\n - 2022-03-30T16:03:35.280820\n\nCreated by\n - Jeet Vora [jeetvora@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Amanda Bell [amandab2140@gwu.edu], Jonathon Keeney [keeneyjg@gwu.edu], Millicent Quartey [mquartey@email.gwu.edu]\n\nAuthors\n - \n\nChecksum\n - \n\nUsability Domain\n - This is a Human Protein Cancer Biomarkers dataset. It contains human [taxonomy:9606] cancer biomarker information including biomarker main x-ref mapped to UniProtKB, assessed biomarker entity, BEST biomarker type, literature evidence, disease name. and LOINC code from the cancer biomarker portal (https://data.oncomx.org/cancerbiomarkers). If you use this dataset, please provide proper attribution to OncoMX and GlyGen. Cite:PMID:32142370, PMID:34015823, and PMID:31616925. This dataset can be used for obtaining cancer biomarker information for 19 cancer types.\n\nDescription Domain\n Keywords\n - biomarker\n - cancer\n\n Pipeline Steps\n - Step-1: The script maps the UniProtKB accession from the source file to UniProtKB canonical accession. The script extracts the other fields as is from the source input file.\n\nExecution Domain\n Scripts - https://github.com/GW-HIVE/glygen-backend-integration/blob/master/pipeline/integrator/make-protein-dataset.py\n\n\n Software Prerequisites\n Name: Python\n Version: 2.7.5\n URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n Input Subdomain\n Name: doid2uberonid_mapping.csv\n URI: https:/data.glygen.org/ln2releases/data/v-1.12.3/misc/doid2uberonid_mapping.csv\n Name: glygen_human_protein_biomarkers_cancer.csv\n URI: https:/data.glygen.org/ln2downloads/biomarkerdb/2022_03_14/glygen_human_protein_biomarkers_cancer.csv\n Output Subdomain\n Name: human_protein_biomarkers_cancer.csv\n URI: https:/data.glygen.org/ln2releases/data/v-1.12.3/reviewed/human_protein_biomarkers_cancer.csv\n Name: human_protein_biomarkers_cancer.stat.csv\n URI: https:/data.glygen.org/ln2releases/data/v-1.12.3/reviewed/human_protein_biomarkers_cancer.stat.csv\n\nFields\n Name: \"uniprotkb_canonical_ac\"\n Description: \"\"\n Unique Values: \"152\"\n Name: \"biomarker_id\"\n Description: \"\"\n Unique Values: \"153\"\n Name: \"assessed_biomarker_entity\"\n Description: \"\"\n Unique Values: \"153\"\n Name: \"biomarker\"\n Description: \"\"\n Unique Values: \"158\"\n Name: \"best_biomarker_type\"\n Description: \"\"\n Unique Values: \"5\"\n Name: \"loinc_code\"\n Description: \"\"\n Unique Values: \"26\"\n Name: \"notes\"\n Description: \"Notes\"\n Unique Values: \"114\"\n Name: \"anatomical_entity\"\n Description: \"\"\n Unique Values: \"15\"\n Name: \"uberon_id\"\n Description: \"\"\n Unique Values: \"17\"\n Name: \"do_id\"\n Description: \"Disease Ontology identifier\"\n Unique Values: \"15\"\n Name: \"do_name\"\n Description: \"Disease Ontology term or name for the disease assigned to the Disease Ontology identifier\"\n Unique Values: \"15\"\n Name: \"xref_key\"\n Description: \"Source key associated to the xref_id\"\n Unique Values: \"2\"\n Name: \"xref_id\"\n Description: \"ID of the X-ref\"\n Unique Values: \"337\"\n Name: \"src_xref_key\"\n Description: \"Source Xref key\"\n Unique Values: \"1\"\n Name: \"src_xref_id\"\n Description: \"Source X-ref ID\"\n Unique Values: \"153\"", "downloadurl": "/ln2data/releases/data/v-1.12.3/reviewed/human_protein_biomarkers_cancer.csv" }