{
    "bcoid": "GLY_000249",
    "title": "Rat Protein Function (NCBI RefSeq)",
    "description": "The Rat Protein Function (NCBI RefSeq) dataset contains biological function annotation of rat [taxid:10116] ...",
    "filename": "rat_protein_function_refseq.csv",
    "filetype": "csv",
    "categories": {
        "species": "Rattus norvegicus",
        "molecule": "Protein",
        "tags": "Protein Function",
        "file_type": "csv",
        "status": "Reviewed",
        "scope": "internal"
    },
    "minitable": {
        "content": [
            [
                "Q9JJK1-1...",
                "protein_xref..."
            ],
            [
                "Q8R512-1...",
                "protein_xref..."
            ]
        ],
        "headers": [
            "uniprotkb_ca...",
            "xref_key..."
        ],
        "colwidth": [
            "40%",
            "20%"
        ]
    },
    "sampledata": {
        "type": "table",
        "data": [
            [
                {
                    "type": "string",
                    "label": "uniprotkb_canonical_ac"
                },
                {
                    "type": "string",
                    "label": "xref_key"
                },
                {
                    "type": "string",
                    "label": "xref_id"
                },
                {
                    "type": "string",
                    "label": "evidence"
                },
                {
                    "type": "string",
                    "label": "annotation"
                }
            ],
            [
                "Q9JJK1-1",
                "protein_xref_refseq",
                "NP_620201",
                "29282769",
                "Study identified glycoprotein M6B as a Schwann cell microvilli component of peripheral nodes of Ranvier. Study detected Na(+) channel clusters at heminodes without any associated M6B, indicating that it is not required for initial channel clustering; showed that absence of M6B results in progressive appearance of nodal protrusions of the nodal axolemma, that are often accompanied by the presence of enlarged mitochondria."
            ],
            [
                "Q8R512-1",
                "protein_xref_refseq",
                "NP_620208",
                "11940653",
                "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers"
            ],
            [
                "Q9Z1Z6-1",
                "protein_xref_refseq",
                "NP_072128",
                "14663150",
                "Distinct functions for mGluR2 and mGluR3 and dynamic regulation of mGluR3 by PP2C"
            ],
            [
                "Q9EPZ7-1",
                "protein_xref_refseq",
                "NP_445893",
                "32636400",
                "CRISRP/Cas9-mediated knockout of Mct8 reveals a functional involvement of Mct8 in testis and sperm development in a rat. Erratum:[Sci Rep. 2020 Nov 11;10(1):19967. PMID: 33177632] Publication Status: Online-Only"
            ],
            [
                "Q9EPZ7-1",
                "protein_xref_refseq",
                "NP_445893",
                "31561916",
                "Differential expression and immunoreactivity of thyroid hormone transporters MCT8 and OATP1C1 in rat ovary."
            ],
            [
                "Q9EPZ7-1",
                "protein_xref_refseq",
                "NP_445893",
                "28688524",
                "Prenatal exposure to monoclonal antibody brain-specific anion transporter-1 blocks brain-specific anion transporter-1 and limits T4 influx to the brain. This impairs the cognitive function in exposed progeny in the post-natal life."
            ],
            [
                "Q9EPZ7-1",
                "protein_xref_refseq",
                "NP_445893",
                "26861177",
                "This study demonstrated that reduction of the Mct8 mRNA expression in hippocampus of thyroidectomized Wistar rats."
            ],
            [
                "Q9EPZ7-1",
                "protein_xref_refseq",
                "NP_445893",
                "25594699",
                "The data demonstrate that OATP1c1 and MCT8 expression are regulated in a parallel manner during inflammation at the blood-brain barrier of rodents."
            ],
            [
                "P11661-1",
                "protein_xref_refseq",
                "AP_004902",
                "",
                "REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CAA32964. for seqs get included see V00681, K00434, J01436, X07479, X07482. Method: conceptual translation."
            ],
            [
                "P20646-1",
                "protein_xref_refseq",
                "NP_001128373",
                "27348306",
                "PAP-immunoreactivity was present in type I and one of type III taste cells of taste buds. Thus, it is suggested that PAP might be a responsible ectoenzyme for metabolism of extracellular nucleotides, being involved in the regulation of taste signaling in taste buds. Publication Status: Online-Only"
            ],
            [
                "P20646-1",
                "protein_xref_refseq",
                "NP_001128373",
                "25482440",
                "Acpp plays an important role in growth and development of the penis of rats, and its expression is modulated at epigenomic levels via specific miRs"
            ],
            [
                "P20646-1",
                "protein_xref_refseq",
                "NP_001128373",
                "25674224",
                "Our findings suggest that the decrease of PAP in dorsal root ganglion neurons is involved in pathophysiological mechanisms of neuropathic pain Publication Status: Online-Only"
            ],
            [
                "Q9EPI8-1",
                "protein_xref_refseq",
                "NP_445951",
                "15087485",
                "The DNA-binding activity of mTERF is unaffected by the phosphorylation or dephosphorylation state, however, only the phosphorylated form of the protein is active for termination activity. Publication Status: Online-Only"
            ],
            [
                "P05508-1",
                "protein_xref_refseq",
                "AP_004901",
                "",
                "REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CAA32963. for seqs get included see V00681, K00434, J01436, X07479, X07482. Method: conceptual translation."
            ],
            [
                "B5DFI9-1",
                "protein_xref_refseq",
                "NP_001100051",
                "32216531",
                "Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis."
            ],
            [
                "B2GV06-1",
                "protein_xref_refseq",
                "NP_001121052",
                "20460097",
                "MRNAs of SCOT and ATP citrate lyase were decreased 55% and 58% and enzyme activities were decreased >70% in pancreatic islets of the GK rat, a model of type 2 diabetes."
            ],
            [
                "Q8VHK2-1",
                "protein_xref_refseq",
                "NP_542421",
                "19523119",
                "Proline-rich region of Caskin1 is biochemically functional, as it interacts with the adaptor protein Abl-interactor-2."
            ],
            [
                "A0A0G2K8Z9-1",
                "protein_xref_refseq",
                "NP_998791",
                "23077056",
                "The forkhead-associated domain of KIF13B binds to TRPV1-containing vesicles and is delivered to the cell surface."
            ],
            [
                "A0A0G2K8Z9-1",
                "protein_xref_refseq",
                "NP_998791",
                "20194617",
                "These results reveal that GAKIN/KIF13B is a key intermediate linking Par1b to the regulation of axon formation."
            ],
            [
                "A0A0G2K8Z9-1",
                "protein_xref_refseq",
                "NP_998791",
                "15923660",
                "Direct binding between centaurin-alpha(1) and KIF13B could concentrate centaurin-alpha(1) at the leading edges of cells, thus modulating ADP-ribosylation factor 6 function."
            ],
            [
                "P97682-1",
                "protein_xref_refseq",
                "NP_072126",
                "23850961",
                "Peripheral blood ESM-1 mRNA and ESM-1 protein expression in kidney grafts can reflect the severity of endothelial cell impairment"
            ],
            [
                "P50609-1",
                "protein_xref_refseq",
                "NP_542429",
                "27665369",
                "The fibromodulin (Fm)-transforming growth factor (TGF)-beta1 nexus plays a crucial in fetal-type scarless skin repair."
            ],
            [
                "P50609-1",
                "protein_xref_refseq",
                "NP_542429",
                "26048315",
                "The effects of liposomal-based delivery of fibromodulin gene were investigated in a rat Achilles tendon injury model. The positive results observed would provide a new therapeutic strategy in clinical setting in the future"
            ],
            [
                "Q71RP1-1",
                "protein_xref_refseq",
                "NP_072127",
                "29581478",
                "We identified Hpse as a previously unexplored candidate, being up-regulated following injury. We confirmed these results and demonstrated inhibition of Hpse led to an acceleration of axonal degeneration, accompanied by an increase in b-catenin Publication Status: Online-Only"
            ],
            [
                "Q71RP1-1",
                "protein_xref_refseq",
                "NP_072127",
                "28720149",
                "Heparanase plays an important role in mediating the neuroinflammatory response after subarachnoid hemorrhage. Publication Status: Online-Only"
            ],
            [
                "Q71RP1-1",
                "protein_xref_refseq",
                "NP_072127",
                "27979811",
                "Endothelial cell-to-cardiomyocyte transfer of heparanase to modulates the cardiomyocyte cell death signature. This mechanism was observed in the acutely diabetic heart, and its interruption following chronic diabetes may contribute towards the development of diabetic cardiomyopathy."
            ],
            [
                "Q71RP1-1",
                "protein_xref_refseq",
                "NP_072127",
                "26638897",
                "The expression of the gene for heparanase was increased in the right and left ventricles after treatment with monocrotaline"
            ],
            [
                "Q71RP1-1",
                "protein_xref_refseq",
                "NP_072127",
                "24608441",
                "Inhibiting heparanase function could offer a new strategy for managing cardiomyopathy observed after diabetes."
            ],
            [
                "Q71RP1-1",
                "protein_xref_refseq",
                "NP_072127",
                "12077130",
                "Characterization of rat heparanase activity in a parathyroid cell line"
            ],
            [
                "Q71RP1-1",
                "protein_xref_refseq",
                "NP_072127",
                "11988100",
                "Characterization of a novel intracellular heparanase that has a FERM domain."
            ],
            [
                "Q6REY9-1",
                "protein_xref_refseq",
                "NP_998794",
                "15234003",
                "RARhoGAP expression was found in differentiating male germ cells and in the testis, suggesting that it may be involved in rearrangements of the cytoskeleton and cell signaling events that occur during spermatogenesis."
            ],
            [
                "Q9QY10-1",
                "protein_xref_refseq",
                "NP_072125",
                "17553847",
                "FGF-BP is an early response gene after spinal cord injury and that its upregulation in regenerating spinal cord tissue may provide a molecular mechanism for enhancing the initial FGF2-mediated neurotrophic effects occurring after such tissue damage"
            ],
            [
                "Q6PCU8-1",
                "protein_xref_refseq",
                "NP_072129",
                "27940020",
                "We describe characterization of the complexes I purified from five rat tissues and from a rat hepatoma cell line. We identify a~50kDa isoform of subunit NDUFV3, for which the canonical isoform is only ~10kDa in size."
            ],
            [
                "Q6PCU8-1",
                "protein_xref_refseq",
                "NP_072129",
                "26686297",
                "OBAP is mainly produced by mitochondria of parietal cells in the upper and lower parts of the gastric epithelium."
            ],
            [
                "A0A0G2K320-1",
                "protein_xref_refseq",
                "NP_001101247",
                "22526486",
                "Sialoadhesin-positive macrophages were increased during the late stage of diabetes concomitantly with the increase of alpha-smooth muscle actin-positive mesangial cells, mesangial matrix area and type IV collagen."
            ],
            [
                "A0A0G2K320-1",
                "protein_xref_refseq",
                "NP_001101247",
                "11971865",
                "Sialoadhesin is a macrophage-restricted adhesion molecule that recognizes N-acetylneuraminylalpha2-3galactose structure. Macrophages in lymph nodes express high levels of unmasked sialoadhesin."
            ],
            [
                "D3ZBS9-1",
                "protein_xref_refseq",
                "NP_001102222",
                "24615205",
                "Demonstrate that Smarcd1 is a critical node integrating the circadian clock and vascular smooth muscle cell physiological homeostasis."
            ],
            [
                "Q6ZMA0-1",
                "protein_xref_refseq",
                "NP_998896",
                "",
                "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]."
            ],
            [
                "P06536-1",
                "protein_xref_refseq",
                "NP_036708",
                "34213722",
                "Norepinephrine and Glucocorticoids Modulate Chronic Unpredictable Stress-Induced Increase in the Type 2 CRF and Glucocorticoid Receptors in Brain Structures Related to the HPA Axis Activation."
            ],
            [
                "P06536-1",
                "protein_xref_refseq",
                "NP_036708",
                "31914623",
                "Amyloid beta has a role in the amyloidogenic pathway and enzymes involved both in Tau hyperphosphorylation and GR activation"
            ],
            [
                "P06536-1",
                "protein_xref_refseq",
                "NP_036708",
                "31071644",
                "Noise-induced hearing loss alters hippocampal glucocorticoid receptor expression in rats."
            ],
            [
                "P06536-1",
                "protein_xref_refseq",
                "NP_036708",
                "31139184",
                "Cannabinoid Receptor 2 Agonist JWH-015 Inhibits Interleukin-1beta-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts and in Adjuvant Induced Arthritis Rat via Glucocorticoid Receptor. Publication Status: Online-Only"
            ],
            [
                "P06536-1",
                "protein_xref_refseq",
                "NP_036708",
                "30532228",
                "The findings also suggest that changes in GR dynamics in the dHipp and AMY modulate the enhancing effect SPS has on fear memory persistence. Publication Status: Online-Only"
            ],
            [
                "P04906-1",
                "protein_xref_refseq",
                "NP_036709",
                "29501922",
                "The cytotoxic action of 2-acetylaminofluorene that give rise to the GST-P(+) single hepatocytes was suggested to be an injury to the excretory pump(s) and the duct of hepatocytes. A new physiological mechanism was hypothesized for the induction of preneoplastic cell populations in the rat liver instead of a genetic mechanism."
            ],
            [
                "P04906-1",
                "protein_xref_refseq",
                "NP_036709",
                "25974399",
                "Data suggest that expression of Gstp1 can be regulated by dietary factors; here, Gstp1 is induced in hepatocytes by carnosic acid, an anticarcinogenic component of rosemary (Rosmarinus officinalis)."
            ],
            [
                "Q00960-1",
                "protein_xref_refseq",
                "NP_036706",
                "34445376",
                "NMDARs Containing NR2B Subunit Do Not Contribute to the LTP Form of Hippocampal Plasticity: In Vivo Pharmacological Evidence in Rats. Publication Status: Online-Only"
            ],
            [
                "Q00960-1",
                "protein_xref_refseq",
                "NP_036706",
                "33843051",
                "Changes in concentrations of NMDA receptor subunit GluN2B, Arc and syntaxin-1 in dorsal hippocampus Schaffer collateral synapses in a rat learned helplessness model of depression."
            ],
            [
                "Q00960-1",
                "protein_xref_refseq",
                "NP_036706",
                "34360755",
                "Bidentatide, a Novel Plant Peptide Derived from Achyranthes bidentata Blume: Isolation, Characterization, and Neuroprotection through Inhibition of NR2B-Containing NMDA Receptors. Publication Status: Online-Only"
            ],
            [
                "Q00960-1",
                "protein_xref_refseq",
                "NP_036706",
                "33485963",
                "Cocaine abstinence modulates NMDA receptor subunit expression: An analysis of the GluN2B subunit in cocaine-seeking behavior."
            ],
            [
                "Q00960-1",
                "protein_xref_refseq",
                "NP_036706",
                "33550485",
                "GluN2A- and GluN2B-immunoreactive type I cells attached to vesicular glutamate transporter 2-immunoreactive afferent nerve terminals of the rat carotid body."
            ],
            [
                "Q01812-1",
                "protein_xref_refseq",
                "NP_036704",
                "27524200",
                "The structure of a high-affinity kainate receptor gluk4 ligand-binding domain crystallized with kainite has been presented."
            ],
            [
                "Q01812-1",
                "protein_xref_refseq",
                "NP_036704",
                "20303934",
                "Presynaptic kainate receptors on GABAergic nerve terminals appear to modulate GABAergic transmission, and in doing so may play an important role in the regulation of PAG neuron excitability."
            ],
            [
                "Q01812-1",
                "protein_xref_refseq",
                "NP_036704",
                "19180187",
                "Adrenalectomy results in increased expression of hippocampal KA1 mRNA, an effect which is reversed by treatment with corticosterone..."
            ],
            [
                "Q00959-1",
                "protein_xref_refseq",
                "NP_036705",
                "34454977",
                "Differential effects of memory enhancing and impairing doses of methylphenidate on serotonin metabolism and 5-HT1A, GABA, glutamate receptor expression in the rat prefrontal cortex."
            ],
            [
                "Q00959-1",
                "protein_xref_refseq",
                "NP_036705",
                "34291567",
                "Knockdown of astrocytic Grin2a aggravates beta-amyloid-induced memory and cognitive deficits through regulating nerve growth factor."
            ],
            [
                "Q00959-1",
                "protein_xref_refseq",
                "NP_036705",
                "34233182",
                "Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIalpha phosphorylation of the GluN2A subunit."
            ],
            [
                "Q00959-1",
                "protein_xref_refseq",
                "NP_036705",
                "34225758",
                "Disrupting the alpha7nAChR-NR2A protein complex exerts antidepressant-like effects. Publication Status: Online-Only"
            ],
            [
                "Q00959-1",
                "protein_xref_refseq",
                "NP_036705",
                "33759085",
                "The NMDA Receptor Subunit (GluN1 and GluN2A) Modulation Following Different Conditions of Cocaine Abstinence in Rat Brain Structures."
            ],
            [
                "P10860-1",
                "protein_xref_refseq",
                "NP_036702",
                "29784783",
                "Findings demonstrate that hippocampal synapse assembly and maintenance require a tripartite molecular complex in which the ligand Cbln2 binds with presynaptic neurexin 1beta (+S4) and postsynaptic GluD1."
            ],
            [
                "P10860-1",
                "protein_xref_refseq",
                "NP_036702",
                "24319738",
                "Glutamate dehydrogenase is differentially regulated in liver and muscle of rats with transplanted Guerin's carcinoma."
            ],
            [
                "P10860-1",
                "protein_xref_refseq",
                "NP_036702",
                "23281078",
                "We find that SIRT4 and GDH1 overexpression play antagonistic roles in regulating gliogenesis"
            ],
            [
                "Q80W90-1",
                "protein_xref_refseq",
                "NP_852032",
                "15585134",
                "Lhx9 and Lhx9alpha isoforms could be implicated in regulating various aspects of neuronal differentiation"
            ],
            [
                "Q8VIL3-1",
                "protein_xref_refseq",
                "NP_671479",
                "24403136",
                "Our results highlight SIP30 as a target to mediate neuropathic pain-evoked negative emotion"
            ],
            [
                "Q8VIL3-1",
                "protein_xref_refseq",
                "NP_671479",
                "19723624",
                "There is an ERK-responsive region in the rat sip30 promoter. Activation of ERK promotes the recruitment of the transcription factor cyclic AMP-response element-binding protein to the sip30 gene promoter"
            ],
            [
                "Q8VIH8-1",
                "protein_xref_refseq",
                "NP_671478",
                "12444065",
                "Unusual amino acid sequence and highly restricted expression suggests that cystatins SC and TE-1 play a very specialized role in the testis and epididymis"
            ],
            [
                "Q80XX4-1",
                "protein_xref_refseq",
                "NP_852033",
                "14718386",
                "Molecular cloning and characterization of Mustang, a nuclear protein expressed during bone development and fracture healing."
            ],
            [
                "D4A3P2-1",
                "protein_xref_refseq",
                "NP_001000166",
                "",
                "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]."
            ],
            [
                "D4A3F2-1",
                "protein_xref_refseq",
                "NP_001000183",
                "",
                "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]."
            ],
            [
                "P52591-1",
                "protein_xref_refseq",
                "NP_446074",
                "21727197",
                "The propose a model in which POM121 and Sun1 interact transiently to promote early steps of interphase nuclear pore complexes assembly."
            ],
            [
                "O88382-1",
                "protein_xref_refseq",
                "NP_446073",
                "22128856",
                "Chronic restraint stress influences hippocampal neuroplasticity by modulation of dendrite branching pattern and spine density paralleled by increased expression levels of synaptic scaffolding proteins."
            ],
            [
                "O88382-1",
                "protein_xref_refseq",
                "NP_446073",
                "22593065",
                "These results suggest that S-SCAM is an essential AMPAR scaffolding molecule for the GluA2-containing pool of AMPARs, which are involved in the constitutive pathway of maintaining synaptic strength."
            ],
            [
                "Q7TT49-1",
                "protein_xref_refseq",
                "NP_446072",
                "18854160",
                "Study reports that MRCK and myosin II-related MYO18A linked by the adaptor protein LRAP35a form a functional tripartite complex, which is responsible for the assembly of lamellar actomyosin bundles and of a subnuclear actomyosin network."
            ],
            [
                "Q62829-1",
                "protein_xref_refseq",
                "NP_062083",
                "26460013",
                "Specific loss of PAK3 expression and pharmacological inhibition of PAK both disrupt activity-dependent phosphorylation of S863 in cortical neurons"
            ],
            [
                "Q62829-1",
                "protein_xref_refseq",
                "NP_062083",
                "23818969",
                "Results show elevated PAK3 expression at both the mRNA and protein level in cJun/AP-1-over-expressing Rat1a fibroblasts, as well as in transformed human fibroblasts. Publication Status: Online-Only"
            ],
            [
                "Q62829-1",
                "protein_xref_refseq",
                "NP_062083",
                "22238087",
                "PAK3 regulates activity-mediated rearrangement of synaptic connectivity associated with learning, suggesting that defects in spine formation and refinement during development could account for intellectual disability."
            ],
            [
                "D4AA14-1",
                "protein_xref_refseq",
                "NP_001132955",
                "16186796",
                "Functional characterization of the mouse Amid ortholog and comparison to the human protein."
            ],
            [
                "D4A8Y0-1",
                "protein_xref_refseq",
                "NP_001094283",
                "27038183",
                "Identified four claudin isoforms (1, 3, 5, and 12) and showed that their expression levels were regulated as a group by copper"
            ],
            [
                "P61794-1",
                "protein_xref_refseq",
                "NP_446388",
                "28342860",
                "The data suggest that the LPAR1 mutants perturb lysophosphatidic acid signaling in cancer tissues."
            ],
            [
                "P61794-1",
                "protein_xref_refseq",
                "NP_446388",
                "27094551",
                "Lysophosphatidic acid and its receptor LPAR1, acting through the Rho-ROCK pathway, regulate P2X3 receptor in the development of both mechanical and spontaneous pain in bone cancer. Publication Status: Online-Only"
            ],
            [
                "P61794-1",
                "protein_xref_refseq",
                "NP_446388",
                "26169757",
                "Results suggest LPA signaling via activation of LPA1 may be necessary for dopamine neuron development and survival"
            ],
            [
                "P61794-1",
                "protein_xref_refseq",
                "NP_446388",
                "26473723",
                "Data showed that lysophosphatidic acid receptors LPA1-3, are phosphoproteins whose phosphorylation state is modulated by the natural agonist, LPA. Publication Status: Online-Only"
            ],
            [
                "P61794-1",
                "protein_xref_refseq",
                "NP_446388",
                "25888792",
                "These findings indicate lysophosphatidylethanolamine increases intracellular Ca(2+) via a LPA-1/Gi/o proteins/phospholipase C/IP3/Ca(2+) rise/Ca(2+) influx pathway in PC-12 neuronal cells."
            ],
            [
                "O35179-1",
                "protein_xref_refseq",
                "NP_446387",
                "31059028",
                "A potential role for endophilin 1 in Abetainduced postsynaptic dysfunction has been identified, indicating a possible direction for the prevention of postsynaptic dysfunction in cognitive impairment and suggesting that endophilin may be a potential target for the clinical treatment of Alzheimer's disease."
            ],
            [
                "O35179-1",
                "protein_xref_refseq",
                "NP_446387",
                "28933693",
                "Together, these observations suggest that while endophilin helps shape endocytic tubules and recruit dynamin to endocytic sites, it can also block membrane fission when present in excess by inhibiting inter-dynamin interactions. Publication Status: Online-Only"
            ]
        ]
    },
    "readme": "Name\n   - Rat Protein Function (NCBI RefSeq)\n\nVersion\n   - 1.11.2\n\nCreated on\n  - 2019-09-06T14:06:38.975527\n\nModified on\n   - 2022-01-19T13:13:56.046976\n\nCreated by\n   - Jeet Vora [jeetvora@gwu.edu], Rahi Navelkar [rsn13@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Xavier Holmes [xavierh@email.gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Amanda Bell [amandab2140@gwu.edu], Jonathon Keeney [keeneyjg@gwu.edu], Millicent Quartey [mquartey@email.gwu.edu]\n\nAuthors\n   - Not Applicable []\n\nChecksum\n   - \n\nUsability Domain\n   - The Rat Protein Function (NCBI RefSeq) dataset contains biological function annotation of rat [taxid:10116] genes from GeneRIF section in the NCBI RefSeq database. The dataset is derived from NCBI RefSeq Release 96, September 9, 2019. If you use this dataset please provide proper attribution to NCBI RefSeq and GlyGen. \n\nDescription Domain\n   Keywords\n   - protein function\n   - NCBI RefSeq\n   - geneRIF\n   - PMID\n\n   Pipeline Steps\n   - Step-1: The script parses the NCBI RefSeq gpff files to extract the geneRIFs that contain protein function. The script also maps RefSeq accessions to the UniProtKB Canonical accessions. \n\nExecution Domain\n   Scripts   - https://github.com/GW-HIVE/glygen-backend-integration/blob/master/pipeline/integrator/make-protein-dataset.py\n\n\n   Software Prerequisites\n      Name: Python\n      Version: 2.7.5\n      URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n   Input Subdomain\n      Name: rat_protein_xref_refseq.csv\n      URI: https:/data.glygen.org/ln2releases/data/v-1.12.3/reviewed/rat_protein_xref_refseq.csv\n      Name: refseq_protein_all_10116.gpff\n      URI: https:/data.glygen.org/ln2downloads/ncbi/refseq/2022_02/refseq_protein_all_10116.gpff\n   Output Subdomain\n      Name: rat_protein_function_refseq.csv\n      URI: https:/data.glygen.org/ln2releases/data/v-1.12.3/reviewed/rat_protein_function_refseq.csv\n      Name: rat_protein_function_refseq.stat.csv\n      URI: https:/data.glygen.org/ln2releases/data/v-1.12.3/reviewed/rat_protein_function_refseq.stat.csv\n\nFields\n      Name: \"uniprotkb_canonical_ac\"\n     Description: \"\"\n      Unique Values: \"6754\"\n      Name: \"xref_key\"\n     Description: \"Source key associated to the  xref_id\"\n      Unique Values: \"1\"\n      Name: \"xref_id\"\n     Description: \"ID of the X-ref\"\n      Unique Values: \"6924\"\n      Name: \"evidence\"\n     Description: \"NCBI PubMed Id (PMID) or DOI (Digital Object Identifier) as evidence for the entry/annotation\"\n      Unique Values: \"13465\"\n      Name: \"annotation\"\n     Description: \"Function annotation from UniProtKB|RefSeq database\"\n      Unique Values: \"13936\"",
    "downloadurl": "/ln2data/releases/data/v-1.12.3/reviewed/rat_protein_function_refseq.csv"
}
