{ "uniprot_canonical_ac": "A2VCX1-1", "uniprot_ac": "A2VCX1", "uniprot_id": "TIPRL_RAT", "mass": { "chemical_mass": 31225.0, "monoisotopic_mass": 31225.0 }, "refseq": { "ac": "NP_001103137", "name": "TIP41-like protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103137" }, "gene_names": [ { "name": "Tiprl", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2VCX1", "id": "A2VCX1" }, { "name": "RGD1310442", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103137", "id": "NP_001103137" }, { "name": "Tiprl", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103137", "id": "NP_001103137" } ], "protein_names": [ { "name": "TIP41-like protein", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2VCX1#names_and_taxonomy", "id": "A2VCX1" }, { "name": "TIP41, TOR signaling pathway regulator-like; CG9578-like; TIP41, TOR signalling pathway regulator-like", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103137", "id": "NP_001103137" }, { "name": "TIP41-like protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103137", "id": "NP_001103137" } ], "function": [ { "annotation": "May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A2VCX1", "url": "https://www.uniprot.org/uniprot/A2VCX1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A2VCX1", "url": "https://www.uniprot.org/uniprot/A2VCX1" } ], "common_name": "Rat" } ], "gene": [ { "name": "Tiprl", "url": "https://www.uniprot.org/uniprot/A2VCX1", "locus": { "chromosome": "13", "start_pos": 83504494, "end_pos": 83478974, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000003048", "url": "https://www.ensembl.org/id/ENSRNOG00000003048" } ] } } ], "crossref": [ { "id": "ENSRNOG00000003048", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000003048", "database": "Bgee" }, { "id": "360869", "url": "https://www.ncbi.nlm.nih.gov/gene/360869", "database": "GeneID" }, { "id": "IPR007303", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007303", "database": "InterPro" }, { "id": "rno:360869", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:360869", "database": "KEGG Pathway" }, { "id": "WGINFNA", "url": "https://omabrowser.org/oma/group/WGINFNA/", "database": "OMA" }, { "id": "1377237at2759", "url": "http://www.orthodb.org/?query=1377237at2759", "database": "OrthoDB" }, { "id": "PTHR21021:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21021:SF16", "database": "PANTHER" }, { "id": "PF04176", "url": "http://pfam.xfam.org/family/PF04176", "database": "Pfam" }, { "id": "PR_A2VCX1", "url": "http://purl.obolibrary.org/obo/PR_PR_A2VCX1", "database": "PRO" }, { "id": "NP_001103137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103137", "database": "RefSeq" }, { "id": "1310442", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310442", "database": "RGD" }, { "id": "A2VCX1", "url": "https://www.uniprot.org/uniprot/A2VCX1", "database": "UniProtKB" }, { "id": "A2VCX1-1", "url": "https://www.uniprot.org/uniprot/A2VCX1-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MMIHGFQSSHQDFSFGPWKLTASKTHIMKSADVEKLADELHMPSLPEMMFGDNVLRIQHGSGFGIEFNATDALRCVNNYQGMLKVACAEEWQESRTEGEHSKEVIKPYDWTYTTDYKGTLLGESLKLKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADKTYMLREYTSRESKIANLMHVPPSLFTEPNEISQYLPIKEAVCEKLVFPERIDPNPVDSESAPSE", "length": 271, "header": "sp|A2VCX1-1|TIPRL_RAT Isoform 1 of TIP41-like protein OS=Rattus norvegicus OX=10116 GN=Tiprl PE=1 SV=1 CANONICAL=A2VCX1-1" }, "isoforms": [ { "isoform_ac": "A2VCX1-1", "url": "https://www.uniprot.org/uniprot/A2VCX1#A2VCX1-1", "sequence": { "sequence": "MMIHGFQSSHQDFSFGPWKLTASKTHIMKSADVEKLADELHMPSLPEMMFGDNVLRIQHGSGFGIEFNATDALRCVNNYQGMLKVACAEEWQESRTEGEHSKEVIKPYDWTYTTDYKGTLLGESLKLKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADKTYMLREYTSRESKIANLMHVPPSLFTEPNEISQYLPIKEAVCEKLVFPERIDPNPVDSESAPSE", "length": 271, "header": "sp|A2VCX1-1|TIPRL_RAT Isoform 1 of TIP41-like protein OS=Rattus norvegicus OX=10116 GN=Tiprl PE=1 SV=1 CANONICAL=A2VCX1-1" }, "locus": { "chromosome": "13", "start_pos": 83504403, "end_pos": 83479808, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000004083", "url": "https://www.ensembl.org/id/ENSRNOT00000004083" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000004083", "url": "https://www.ensembl.org/id/ENSRNOP00000004083" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 265, "end_pos": 265, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2VCX1", "url": "https://www.uniprot.org/uniprot/A2VCX1" } ] }, { "start_pos": 270, "end_pos": 270, "kinase_uniprot_canonical_ac": "Q703I1-1", "kinase_gene_name": "Oser1", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2VCX1", "url": "https://www.uniprot.org/uniprot/A2VCX1" }, { "database": "iPTMnet", "id": "A2VCX1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2VCX1" }, { "database": "PubMed", "id": "22673903", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903" } ] }, { "start_pos": 270, "end_pos": 270, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2VCX1", "url": "https://www.uniprot.org/uniprot/A2VCX1" }, { "database": "PubMed", "id": "22673903", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903" } ] } ], "glycation": [], "keywords": [], "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "A2VCX1", "url": "https://www.uniprot.org/uniprot/A2VCX1" }, { "database": "iPTMnet", "id": "A2VCX1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2VCX1" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903" } ] } ], "pathway": [ { "id": "rno:360869", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:360869", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O75663-1", "protein_name": "TIP41-like protein", "gene_name": "TIPRL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMIHGFQSSHRDFCFGPWKLTASKTHIMKSADVEKLADELHMPSLPEMMFGDNVLRIQHGSGFGIEFNATDALRCVNNYQGMLKVACAEEWQESRTEGEHSKEVIKPYDWTYTTDYKGTLLGESLKLKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADKTYMLREYTSRESKISSLMHVPPSLFTEPNEISQYLPIKEAVCEKLIFPERIDPNPADSQKSTQVE", "length": 272 }, "evidence": [ { "id": "7140", "url": "http://www.informatics.jax.org/homology/7140", "database": "MGI" }, { "id": "A2VCX1", "url": "https://omabrowser.org/oma/group/A2VCX1/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BH58-1", "protein_name": "TIP41-like protein", "gene_name": "Tiprl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMIHGFQSSHQDFSFGPWKLTASKTHIMKSADVEKLADELHMPSLPEMMFGDNVLRIQHGSGFGIEFNATDALRCVNNYQGMLKVACAEEWQESRTEGEHSKEVIKPYDWTYTTDYKGTLLGESLKLKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADKTYMLREYTSRESKIANLMHVPPSLFTEPNEISQYLPIKEAVCEKLVFPERIDPNPVDSQSTPSE", "length": 271 }, "evidence": [ { "id": "7140", "url": "http://www.informatics.jax.org/homology/7140", "database": "MGI" }, { "id": "A2VCX1", "url": "https://omabrowser.org/oma/group/A2VCX1/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of phosphoprotein phosphatase activity", "id": "GO:0043666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043666", "evidence": [ { "database": "UniProtKB", "id": "A2VCX1", "url": "https://www.uniprot.org/uniprot/A2VCX1" } ], "pmid": "21873635" }, { "name": "TOR signaling", "id": "GO:0031929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031929", "evidence": [ { "database": "UniProtKB", "id": "A2VCX1", "url": "https://www.uniprot.org/uniprot/A2VCX1" } ], "pmid": "21873635" }, { "name": "DNA damage checkpoint signaling", "id": "GO:0000077", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000077", "evidence": [ { "database": "UniProtKB", "id": "A2VCX1", "url": "https://www.uniprot.org/uniprot/A2VCX1" } ], "pmid": "" }, { "name": "negative regulation of phosphoprotein phosphatase activity", "id": "GO:0032515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032515", "evidence": [ { "database": "UniProtKB", "id": "A2VCX1", "url": "https://www.uniprot.org/uniprot/A2VCX1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A2VCX1", "url": "https://www.uniprot.org/uniprot/A2VCX1" } ], "pmid": "21873635" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 197, "end_pos": 199, "annotation": "n_glycosylation_sequon" }, { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ] }