{ "uniprot_canonical_ac": "A2ARP9-1", "uniprot_ac": "A2ARP9", "uniprot_id": "CTSR2_MOUSE", "mass": { "chemical_mass": 68572.0, "monoisotopic_mass": 68572.0 }, "refseq": { "ac": "NP_694715", "name": "cation channel sperm-associated protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694715" }, "gene_names": [ { "name": "Catsper2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9" }, { "name": "Catsper2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694715", "id": "NP_694715" } ], "protein_names": [ { "name": "Cation channel sperm-associated protein 2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2ARP9#names_and_taxonomy", "id": "A2ARP9" }, { "name": "CatSper2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ARP9#names_and_taxonomy", "id": "A2ARP9" }, { "name": "Cation channel sperm-associated protein 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ARP9#names_and_taxonomy", "id": "A2ARP9" }, { "name": "cation channel sperm-associated protein 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694715", "id": "NP_694715" } ], "function": [ { "annotation": "CatSper-null mutant spermatozoa are unable to ascend beyond the oviductal reservoir.", "evidence": [ { "database": "RefSeq", "id": "NP_694715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694715" } ] }, { "annotation": "CatSper1 and CatSper2 null sperm show identical phenotypes in mice", "evidence": [ { "database": "RefSeq", "id": "NP_694715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694715" } ] }, { "annotation": "Data suggest that Catsper1, Catsper2, Catsper3, and Catsper4 form protein multimer with hypothetical activities of flippase and disulfide isomerase.", "evidence": [ { "database": "RefSeq", "id": "NP_694715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694715" } ] }, { "annotation": "Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Catsper2", "url": "https://www.uniprot.org/uniprot/A2ARP9", "locus": { "chromosome": "2", "start_pos": 121413792, "end_pos": 121392631, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000033486", "url": "https://www.ensembl.org/id/ENSMUSG00000033486" } ] } } ], "crossref": [ { "id": "ENSMUSG00000033486", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000033486", "database": "Bgee" }, { "id": "212670", "url": "https://www.ncbi.nlm.nih.gov/gene/212670", "database": "GeneID" }, { "id": "A2ARP9", "url": "https://www.ebi.ac.uk/intact/interactors/id:A2ARP9*", "database": "IntAct" }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro" }, { "id": "IPR027359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027359", "database": "InterPro" }, { "id": "IPR028747", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028747", "database": "InterPro" }, { "id": "mmu:212670", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:212670", "database": "KEGG Pathway" }, { "id": "2387404", "url": "http://www.informatics.jax.org/marker/MGI:2387404", "database": "MGI" }, { "id": "GVYFFED", "url": "https://omabrowser.org/oma/group/GVYFFED/", "database": "OMA" }, { "id": "580290at2759", "url": "http://www.orthodb.org/?query=580290at2759", "database": "OrthoDB" }, { "id": "PTHR46923", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46923", "database": "PANTHER" }, { "id": "PF00520", "url": "http://pfam.xfam.org/family/PF00520", "database": "Pfam" }, { "id": "PR_A2ARP9", "url": "http://purl.obolibrary.org/obo/PR_PR_A2ARP9", "database": "PRO" }, { "id": "R-MMU-1300642", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1300642", "database": "Reactome" }, { "id": "NP_694715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694715", "database": "RefSeq" }, { "id": "A0A0A0MQ85", "url": "https://www.uniprot.org/uniprot/A0A0A0MQ85", "database": "UniProtKB" }, { "id": "A0A0A0MQ85-1", "url": "https://www.uniprot.org/uniprot/A0A0A0MQ85-1", "database": "UniProtKB" }, { "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9", "database": "UniProtKB" }, { "id": "A2ARP9-1", "url": "https://www.uniprot.org/uniprot/A2ARP9-1", "database": "UniProtKB" }, { "id": "D6RCY8", "url": "https://www.uniprot.org/uniprot/D6RCY8", "database": "UniProtKB" }, { "id": "D6RCY8-1", "url": "https://www.uniprot.org/uniprot/D6RCY8-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MAQEQGHFQLLRADAIRSKLIDTFSLIEHLQGLSQAVPRHTLREILDPSYQQKLMSGDQEQLVRFSIKPRRMGHITHSRRLLSRLRVRCSRMPPLSLWAGWVLDSSVFSKFIISLIFLNTFVLMVEIELMESTNTALWPVKLALEVADWFILLSFIVEILLMWLASFSLFWKDAWNVFDFFVTLLSLLPELVVLLGVPAHSVWLQLLRVCRVLRSLKLFARFRQIKVILLALVRALKSMTFLLMLLLIFFYIFAVTGVYFFREYSRSTIEGLEYNMFFSDLLNSLVTVFILFTLDHWYAVLQDIWKVPESSRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQNIRSELSEEMSHLEVQYKADMFKQQIIQRRQHSESLRGTSLGKVSEDIIETSDASDDDDDDDDDDDDDDDDDDDKSDATESDNEESDSENSESENSESEKIDPEKDYAKKSYPEKSHPEKSYPEKSHPEKSYPEKSHPKKSYDEQAEAEKVKEESKEKAYPVSHSISSHGSTAADTAFLENLDWETLVHENLPGLMDMDQDDRIVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMSFEDK", "length": 588, "header": "sp|A2ARP9-1|CTSR2_MOUSE Isoform 1 of Cation channel sperm-associated protein 2 OS=Mus musculus OX=10090 GN=Catsper2 PE=1 SV=2 CANONICAL=A2ARP9-1" }, "isoforms": [ { "isoform_ac": "A0A0A0MQ85-1", "url": "https://www.uniprot.org/uniprot/A2ARP9#A0A0A0MQ85-1", "sequence": { "sequence": "MAQEQGHFQLLRADAIRSKLIDTFSLIEHLQGLSQAVPRHTLREILDPSYQQKLMSGDQEQLVRFSIKPRRMGHITHSRRLLSRLRVRCSRMPPLSLWAGWVLDSSVFSKFIISLIFLNTFVLMVEIELMESTNTALWPVKLALEVADWFILLSFIVEILLMWLASFSLFWKDAWNVFDFFVTLLSLLPELVVLLGVPAHSVWLQLLRVCRVLRSLKLFARFRQIKVILLALVRALKSMTFLLMLLLIFFYIFAVTGVYFFREYSRSTIEGLEYNMFFSDLLNSLVTVFILFTLDHWYAVLQDIWKVPESSRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQNIRSELSEEMSHLEVQYKADMFKQQIIQRRQHSESLRGTSLGKVSEDIIETSDASDDDDDDDDDDDDDDDDDDKSDATESDGEKNENEESDSENSESENSESEKIDPEKDYAKKSYPEKSHPEKSYPEKSHPEKSYPEKSHPKKSYDEQAEAEESKEKAYPVSHSISSHGSTAADTAFLENLDWETLVHENLPGLMDMDQDDRIVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMSFEDK", "length": 588, "header": "tr|A0A0A0MQ85-1|CTSR2_MOUSE Computationally mapped isoform of Cation channel sperm-associated protein 2 OS=Mus musculus OX=10090 GN=Catsper2 PE=1 SV=1 CANONICAL=A2ARP9-1" }, "locus": { "chromosome": "2", "start_pos": 121242769, "end_pos": 121224940, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000038073", "url": "https://www.ensembl.org/id/ENSMUST00000038073" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000037222", "url": "https://www.ensembl.org/id/ENSMUSP00000037222" } ] } }, { "isoform_ac": "A2ARP9-1", "url": "https://www.uniprot.org/uniprot/A2ARP9#A2ARP9-1", "sequence": { "sequence": "MAQEQGHFQLLRADAIRSKLIDTFSLIEHLQGLSQAVPRHTLREILDPSYQQKLMSGDQEQLVRFSIKPRRMGHITHSRRLLSRLRVRCSRMPPLSLWAGWVLDSSVFSKFIISLIFLNTFVLMVEIELMESTNTALWPVKLALEVADWFILLSFIVEILLMWLASFSLFWKDAWNVFDFFVTLLSLLPELVVLLGVPAHSVWLQLLRVCRVLRSLKLFARFRQIKVILLALVRALKSMTFLLMLLLIFFYIFAVTGVYFFREYSRSTIEGLEYNMFFSDLLNSLVTVFILFTLDHWYAVLQDIWKVPESSRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQNIRSELSEEMSHLEVQYKADMFKQQIIQRRQHSESLRGTSLGKVSEDIIETSDASDDDDDDDDDDDDDDDDDDDKSDATESDNEESDSENSESENSESEKIDPEKDYAKKSYPEKSHPEKSYPEKSHPEKSYPEKSHPKKSYDEQAEAEKVKEESKEKAYPVSHSISSHGSTAADTAFLENLDWETLVHENLPGLMDMDQDDRIVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMSFEDK", "length": 588, "header": "sp|A2ARP9-1|CTSR2_MOUSE Isoform 1 of Cation channel sperm-associated protein 2 OS=Mus musculus OX=10090 GN=Catsper2 PE=1 SV=2 CANONICAL=A2ARP9-1" }, "locus": {} }, { "isoform_ac": "D6RCY8-1", "url": "https://www.uniprot.org/uniprot/A2ARP9#D6RCY8-1", "sequence": { "sequence": "MAQEQGHFQLLRADAIRSKLIDTFSLIEHLQGLSQAVPRHTLREILDPSYQQKLMSGDQEQLVRFSIKPRRMGHITHSRRLLSRLRVRCSRMPPLSLWAGWVLDSSVFSKFIISLIFLNTFVLMVEIGDSTLNH", "length": 134, "header": "tr|D6RCY8-1|D6RCY8_MOUSE Computationally mapped isoform of Cation channel sperm-associated protein 2 OS=Mus musculus OX=10090 GN=Catsper2 PE=4 SV=1 CANONICAL=A2ARP9-1" }, "locus": { "chromosome": "2", "start_pos": 121242769, "end_pos": 121229931, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000154604", "url": "https://www.ensembl.org/id/ENSMUST00000154604" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000119091", "url": "https://www.ensembl.org/id/ENSMUSP00000119091" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "A voltage-gated ion channel expressed specifically in spermatozoa.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2001", "authors": "Garbers D.L., Clapham D.E., Ren D., Quill T.A.", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "reference": [ { "type": "PubMed", "id": "11675491", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11675491" } ] }, { "title": "Hyperactivated sperm motility driven by CatSper2 is required for fertilization.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2003", "authors": "Garbers D.L., Quill T.A., Doolittle L.K., Hammer R.E., Rossi K.L., Sugden S.A.", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "reference": [ { "type": "PubMed", "id": "14657366", "url": "https://www.ncbi.nlm.nih.gov/pubmed/14657366" } ] }, { "title": "Identical phenotypes of CatSper1 and CatSper2 null sperm.", "journal": "J. Biol. Chem.", "date": "2005", "authors": "Westenbroek R.E., Quill T.A., Hille B., Babcock D.F., Carlson A.E., Schuh S.M.", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" }, { "database": "RefSeq", "id": "NP_694715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694715" } ], "reference": [ { "type": "PubMed", "id": "16036917", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16036917" } ] }, { "title": "Contributions of extracellular and intracellular Ca2+ to regulation of sperm motility: release of intracellular stores can hyperactivate CatSper1 and CatSper2 null sperm.", "journal": "Dev. Biol.", "date": "2007", "authors": "Marquez B., Suarez S.S., Ignotz G.", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "reference": [ { "type": "PubMed", "id": "17174296", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17174296" } ] }, { "title": "Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility.", "journal": "Mol. Hum. Reprod.", "date": "2007", "authors": "Ding X.-F., Kong X.-B., Li H.-G., Liao A.-H., Xiong C.-L.", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "reference": [ { "type": "PubMed", "id": "17347248", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17347248" } ] }, { "title": "CatSper-null mutant spermatozoa are unable to ascend beyond the oviductal reservoir.", "journal": "Reproduction, fertility, and development", "date": "2009", "authors": "Ho K, Wolff CA, Suarez SS", "evidence": [ { "database": "RefSeq", "id": "NP_694715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694715" } ], "reference": [ { "type": "PubMed", "id": "19210926", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19210926" } ] }, { "title": "A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa.", "journal": "Nat. Commun.", "date": "2011", "authors": "Clapham D.E., Krapivinsky G., Krapivinsky L., Chung J.J., Navarro B.", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "reference": [ { "type": "PubMed", "id": "21224844", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21224844" } ] }, { "title": "Progesterone activates the principal Ca2+ channel of human sperm.", "journal": "Nature", "date": "2011", "authors": "Kirichok Y., Lishko P.V., Botchkina I.L.", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "reference": [ { "type": "PubMed", "id": "21412339", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21412339" } ] }, { "title": "Intramembranal disulfide cross-linking elucidates the super-quaternary structure of mammalian CatSpers.", "journal": "Reproductive biology", "date": "2018", "authors": "Bystroff C", "evidence": [ { "database": "RefSeq", "id": "NP_694715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694715" } ], "reference": [ { "type": "PubMed", "id": "29371110", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29371110" } ] } ], "pathway": [ { "id": "mmu:212670", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:212670", "resource": "KEGG Pathway" }, { "id": "R-MMU-1300642", "name": "Sperm Motility And Taxes", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1300642", "resource": "Reactome", "description": "Sperm Motility And Taxes" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6AXP6-1", "protein_name": "Cation channel sperm-associated protein 2", "gene_name": "Catsper2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAHERGHLQLPRADAIRSKLIDTFSLIEHLQGLSQAVPRHTLREILDPACQKKLMLGDQEQLVRFSIRARRMGHITHAQRLLSRLRVRCGGRPPLSLWAGWVLDSSIFSNFIISLIFLNTFVLMVEIELMNSTNTSLWPLKLALEVTDWFILLSFIVEILLMWLASFFLFWKNAWSVFDFVVTMLSLLPEFVVLIGVSADSVWLQLLRVSRVLRSLKLFARFPQIKVILLALVRALKSMTFLLMLLLIFFYVFAVAGVYFFKEYSRSTIENLEYNMFFSDLLNSLVTVFILFTLDHWYAVLQDVWKVPEASRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQNIRNELHEEMTHLEVQYKADIFKRRIIQRRQQSESLRGTSQGKVSEDITETSEATDEEKSEAEESEEEKSEEEKSDVEKSDEEKNDEEKSDEEENDEEKSDVEKSDEEKNDEEKGYTEKVYSGRTFVERSYAERSFAGKAENEKVQKELKEKAYPGSPPNSSSHDEAFAADDTYLENLDWETLVHENLPGLMDMDQDDRVVWPRDSLFRYFELLESLQYNLEERKRLQEFAVQALMNFEDK", "length": 584 }, "evidence": [ { "id": "77423", "url": "http://www.informatics.jax.org/homology/77423", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96P56-1", "protein_name": "Cation channel sperm-associated protein 2", "gene_name": "CATSPER2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGDQHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVSEVESNYGATEEDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPGLMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK", "length": 530 }, "evidence": [ { "id": "77423", "url": "http://www.informatics.jax.org/homology/77423", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "CatSper complex", "id": "GO:0036128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036128", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "pmid": "" }, { "name": "CatSper complex", "id": "GO:0036128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036128", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "pmid": "21224844" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "pmid": "11675491" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "pmid": "14657366" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "pmid": "" }, { "name": "fertilization", "id": "GO:0009566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009566", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "pmid": "14657366" }, { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "pmid": "14657366" }, { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "pmid": "17174296" }, { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "pmid": "17227845" }, { "name": "sperm capacitation", "id": "GO:0048240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048240", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "pmid": "14657366" }, { "name": "regulation of ion transmembrane transport", "id": "GO:0034765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034765", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "calcium activated cation channel activity", "id": "GO:0005227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005227", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "pmid": "" }, { "name": "calcium channel activity", "id": "GO:0005262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005262", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "pmid": "" }, { "name": "voltage-gated ion channel activity", "id": "GO:0005244", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005244", "evidence": [ { "database": "UniProtKB", "id": "A2ARP9", "url": "https://www.uniprot.org/uniprot/A2ARP9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }