{ "uniprot_canonical_ac": "A2ARP1-1", "uniprot_ac": "A2ARP1", "uniprot_id": "VIP1_MOUSE", "mass": { "chemical_mass": 159923.0, "monoisotopic_mass": 159923.0 }, "refseq": { "ac": "NP_848910", "name": "inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848910" }, "gene_names": [ { "name": "Ppip5k1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2ARP1", "id": "A2ARP1" }, { "name": "B430315C20Rik; Hisppd2a; mKIAA0377", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848910", "id": "NP_848910" }, { "name": "Hisppd2a", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ARP1", "id": "A2ARP1" }, { "name": "Kiaa0377", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ARP1", "id": "A2ARP1" }, { "name": "Ppip5k1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848910", "id": "NP_848910" }, { "name": "Vip1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ARP1", "id": "A2ARP1" } ], "protein_names": [ { "name": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2ARP1#names_and_taxonomy", "id": "A2ARP1" }, { "name": "2.7.4.21", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ARP1#names_and_taxonomy", "id": "A2ARP1" }, { "name": "2.7.4.24", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ARP1#names_and_taxonomy", "id": "A2ARP1" }, { "name": "Diphosphoinositol pentakisphosphate kinase 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ARP1#names_and_taxonomy", "id": "A2ARP1" }, { "name": "Histidine acid phosphatase domain-containing protein 2A", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ARP1#names_and_taxonomy", "id": "A2ARP1" }, { "name": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ARP1#names_and_taxonomy", "id": "A2ARP1" }, { "name": "InsP6 and PP-IP5 kinase 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ARP1#names_and_taxonomy", "id": "A2ARP1" }, { "name": "VIP1 homolog; insP6 and PP-IP5 kinase 1; histidine acid phosphatase domain-containing protein 2A; histidine acid phosphatase domain containing 2A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848910", "id": "NP_848910" }, { "name": "VIP1 homolog", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ARP1#names_and_taxonomy", "id": "A2ARP1" }, { "name": "inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848910", "id": "NP_848910" } ], "function": [ { "annotation": "Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress.", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Ppip5k1", "url": "https://www.uniprot.org/uniprot/A2ARP1", "locus": { "chromosome": "2", "start_pos": 121355396, "end_pos": 121310561, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000033526", "url": "https://www.ensembl.org/id/ENSMUSG00000033526" } ] } } ], "crossref": [ { "id": "ENSMUSG00000033526", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000033526", "database": "Bgee" }, { "id": "cd07061", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07061", "database": "CDD" }, { "id": "327655", "url": "https://www.ncbi.nlm.nih.gov/gene/327655", "database": "GeneID" }, { "id": "IPR000560", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000560", "database": "InterPro" }, { "id": "IPR029033", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029033", "database": "InterPro" }, { "id": "IPR033379", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033379", "database": "InterPro" }, { "id": "IPR037446", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037446", "database": "InterPro" }, { "id": "IPR040557", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040557", "database": "InterPro" }, { "id": "mmu:327655", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:327655", "database": "KEGG Pathway" }, { "id": "2443281", "url": "http://www.informatics.jax.org/marker/MGI:2443281", "database": "MGI" }, { "id": "YLAHIVI", "url": "https://omabrowser.org/oma/group/YLAHIVI/", "database": "OMA" }, { "id": "93740at2759", "url": "http://www.orthodb.org/?query=93740at2759", "database": "OrthoDB" }, { "id": "PTHR12750", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12750", "database": "PANTHER" }, { "id": "PF00328", "url": "http://pfam.xfam.org/family/PF00328", "database": "Pfam" }, { "id": "PF18086", "url": "http://pfam.xfam.org/family/PF18086", "database": "Pfam" }, { "id": "PR_A2ARP1", "url": "http://purl.obolibrary.org/obo/PR_PR_A2ARP1", "database": "PRO" }, { "id": "R-MMU-1855167", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855167", "database": "Reactome" }, { "id": "NP_848910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848910", "database": "RefSeq" }, { "id": "10276", "url": "https://www.rhea-db.org/rhea/10276", "database": "Rhea" }, { "id": "12793", "url": "https://www.rhea-db.org/rhea/12793", "database": "Rhea" }, { "id": "37459", "url": "https://www.rhea-db.org/rhea/37459", "database": "Rhea" }, { "id": "37467", "url": "https://www.rhea-db.org/rhea/37467", "database": "Rhea" }, { "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1", "database": "UniProtKB" }, { "id": "A2ARP1-1", "url": "https://www.uniprot.org/uniprot/A2ARP1-1", "database": "UniProtKB" }, { "id": "A2ARP1-2", "url": "https://www.uniprot.org/uniprot/A2ARP1-2", "database": "UniProtKB" }, { "id": "A2ARP1-3", "url": "https://www.uniprot.org/uniprot/A2ARP1-3", "database": "UniProtKB" }, { "id": "A2ARP1-5", "url": "https://www.uniprot.org/uniprot/A2ARP1-5", "database": "UniProtKB" }, { "id": "A2ARP1-6", "url": "https://www.uniprot.org/uniprot/A2ARP1-6", "database": "UniProtKB" }, { "id": "A2ARP1-7", "url": "https://www.uniprot.org/uniprot/A2ARP1-7", "database": "UniProtKB" }, { "id": "B0R0E7", "url": "https://www.uniprot.org/uniprot/B0R0E7", "database": "UniProtKB" }, { "id": "B0R0E7-1", "url": "https://www.uniprot.org/uniprot/B0R0E7-1", "database": "UniProtKB" }, { "id": "F6Q5C6", "url": "https://www.uniprot.org/uniprot/F6Q5C6", "database": "UniProtKB" }, { "id": "F6Q5C6-1", "url": "https://www.uniprot.org/uniprot/F6Q5C6-1", "database": "UniProtKB" }, { "id": "F6RMX0", "url": "https://www.uniprot.org/uniprot/F6RMX0", "database": "UniProtKB" }, { "id": "F6RMX0-1", "url": "https://www.uniprot.org/uniprot/F6RMX0-1", "database": "UniProtKB" }, { "id": "F6VID9", "url": "https://www.uniprot.org/uniprot/F6VID9", "database": "UniProtKB" }, { "id": "F6VID9-1", "url": "https://www.uniprot.org/uniprot/F6VID9-1", "database": "UniProtKB" }, { "id": "F6VU93", "url": "https://www.uniprot.org/uniprot/F6VU93", "database": "UniProtKB" }, { "id": "F6VU93-1", "url": "https://www.uniprot.org/uniprot/F6VU93-1", "database": "UniProtKB" }, { "id": "F7AST3", "url": "https://www.uniprot.org/uniprot/F7AST3", "database": "UniProtKB" }, { "id": "F7AST3-1", "url": "https://www.uniprot.org/uniprot/F7AST3-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MWSLTANEDESTTAHFFLGAGDEGLGTCGIGMRTEESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPSCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPACPEECSLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVTHPRFFALFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPEAEIEEKTGKLEQLKSVLEMYGHFSGINRKVQLTYYPHGVKASNEGQDLQREPLAPSLLLVLKWGGELTPDGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQHRVKARLHHILQQDAPFGPEDYDQLAPTGSTSLLNSMSVIQNPVKVCDQVFALIENLTHQIRERMQDPSSVDLQLYHSETLELMLQRWSKLERDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGTAELLRLSKALADVVIPQEYGISREEKVEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLDETQDAQWQRALAYLSAISELNYMTQIVIMLYEDNTRDPLSEERFHVELHFSPGVKGVEEGSAPAGCGFRPASSENEEMKTDPGSIENLCPGKASDEPDRALQTSPQPVEGTGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARTHGKKLPPASLKHRDELLFVPAVKRFSVSFAKHPTNGFEGCSMVPTIYPLETLHNALSLRQVSEFLTKVCQRHTDAHAQASAALFDSMHNHQASDSPFSPPRTLHSPPLQLRHRSEKPPWYSSGPSSTVSSAGPSSPTTVDGNSHFGFSDQSSVNIHMTEEKQGFGLLQETPGDGTRELHIERQQELVEPAQSPQELPVEICPSGSQGVTKVSQTCQEVPDIVQPCHNIHEEIGQPQQEVPDISQLLLKDHDTTTNTCHLCQASQLSQKVCEEICQLCQDNHEESNQLCQEVSVKLGRMVHGFPVNVDSTAQETLMEIGRPTQEIPEDPYQEFSVKVGVLAQKAPAISELSQDIPEADKPSQELSEETELQAQEVSEEIDQESEVVDELPPEAIS", "length": 1436, "header": "sp|A2ARP1-1|VIP1_MOUSE Isoform 1 of Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS=Mus musculus OX=10090 GN=Ppip5k1 PE=1 SV=1 CANONICAL=A2ARP1-1" }, "isoforms": [ { "isoform_ac": "A2ARP1-1", "url": "https://www.uniprot.org/uniprot/A2ARP1#A2ARP1-1", "sequence": { "sequence": "MWSLTANEDESTTAHFFLGAGDEGLGTCGIGMRTEESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPSCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPACPEECSLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVTHPRFFALFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPEAEIEEKTGKLEQLKSVLEMYGHFSGINRKVQLTYYPHGVKASNEGQDLQREPLAPSLLLVLKWGGELTPDGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQHRVKARLHHILQQDAPFGPEDYDQLAPTGSTSLLNSMSVIQNPVKVCDQVFALIENLTHQIRERMQDPSSVDLQLYHSETLELMLQRWSKLERDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGTAELLRLSKALADVVIPQEYGISREEKVEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLDETQDAQWQRALAYLSAISELNYMTQIVIMLYEDNTRDPLSEERFHVELHFSPGVKGVEEGSAPAGCGFRPASSENEEMKTDPGSIENLCPGKASDEPDRALQTSPQPVEGTGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARTHGKKLPPASLKHRDELLFVPAVKRFSVSFAKHPTNGFEGCSMVPTIYPLETLHNALSLRQVSEFLTKVCQRHTDAHAQASAALFDSMHNHQASDSPFSPPRTLHSPPLQLRHRSEKPPWYSSGPSSTVSSAGPSSPTTVDGNSHFGFSDQSSVNIHMTEEKQGFGLLQETPGDGTRELHIERQQELVEPAQSPQELPVEICPSGSQGVTKVSQTCQEVPDIVQPCHNIHEEIGQPQQEVPDISQLLLKDHDTTTNTCHLCQASQLSQKVCEEICQLCQDNHEESNQLCQEVSVKLGRMVHGFPVNVDSTAQETLMEIGRPTQEIPEDPYQEFSVKVGVLAQKAPAISELSQDIPEADKPSQELSEETELQAQEVSEEIDQESEVVDELPPEAIS", "length": 1436, "header": "sp|A2ARP1-1|VIP1_MOUSE Isoform 1 of Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS=Mus musculus OX=10090 GN=Ppip5k1 PE=1 SV=1 CANONICAL=A2ARP1-1" }, "locus": { "chromosome": "2", "start_pos": 121181104, "end_pos": 121142140, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000052029", "url": "https://www.ensembl.org/id/ENSMUST00000052029" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000057632", "url": "https://www.ensembl.org/id/ENSMUSP00000057632" } ] } }, { "isoform_ac": "A2ARP1-2", "url": "https://www.uniprot.org/uniprot/A2ARP1#A2ARP1-2", "sequence": { "sequence": "MWSLTANEDESTTAHFFLGAGDEGLGTCGIGMRTEESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPSCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPACPEECSLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVTHPRFFALFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPEAEIEEKTGKLEQLKSVLEMYGHFSGINRKVQLTYYPHGVKASNEGQDLQREPLAPSLLLVLKWGGELTPDGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQHRVKARLHHILQQDAPFGPEDYDQLAPTGSTSLLNSMSVIQNPVKVCDQVFALIENLTHQIRERMQDPSSVDLQLYHSETLELMLQRWSKLERDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGTAELLRLSKALADVVIPQEYGISREEKVEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLESHVHSLLSVFRYGGLLDETQDAQWQRALAYLSAISELNYMTQIVIMLYEDNTRDPLSEERFHVELHFSPGVKGVEEGSAPAGCGFRPASSENEEMKTDPGSIENLCPGKASDEPDRALQTSPQPVEGTGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARTHGKKLPPASLKHRDELLFVPAVKRFSVSFAKHPTNGFEGCSMVPTIYPLETLHNALSLRQVSEFLTKVCQRHTDAHAQASAALFDSMHNHQASDSPFSPPRTLHSPPLQLRHRSEKPPWYSSGPSSTVSSAGPSSPTTVDGNSHFGFSDQSSVNIHMTEEKQGFGLLQETPGDGTRELHIERQQELVEPAQSPQELPVEICPSGSQGVTKVSQTCQEVPDIVQPCHNIHEEIGQPQQEVPDISQLLLKDHDTTTNTCHLCQASQLSQKVCEEICQLCQDNHEESNQLCQEVSVKLGRMVHGFPVNVDSTAQETLMEIGRPTQEIPEDPYQEFSVKVGVLAQKAPAISELSQDIPEADKPSQELSEETELQAQEVSEEIDQESEVVDELPPEAIS", "length": 1416, "header": "sp|A2ARP1-2|VIP1_MOUSE Isoform 2 of Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS=Mus musculus OX=10090 GN=Ppip5k1 PE=1 SV=1 CANONICAL=A2ARP1-1" }, "locus": { "chromosome": "2", "start_pos": 121181104, "end_pos": 121142140, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000110628", "url": "https://www.ensembl.org/id/ENSMUST00000110628" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000106258", "url": "https://www.ensembl.org/id/ENSMUSP00000106258" } ] } }, { "isoform_ac": "A2ARP1-3", "url": "https://www.uniprot.org/uniprot/A2ARP1#A2ARP1-3", "sequence": { "sequence": "MWSLTANEDESTTAHFFLGAGDEGLGTCGIGMRTEESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPSCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPACPEECSLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVTHPRFFALFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPEAEIEEKTGKLEQLKSVLEMYGHFSGINRKVQLTYYPHGVKASNEGQDLQREPLAPSLLLVLKWGGELTPDGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQHRVKARLHHILQQDAPFGPEDYDQLAPTGSTSLLNSMSVIQNPVKVCDQVFALIENLTHQIRERMQDPSSVDLQLYHSETLELMLQRWSKLERDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGTAELLRLSKALADVVIPQEYGISREEKVEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLDETQDAQWQRALAYLSAISELNYMTQIVIMLYEDNTRDPLSEERFHVELHFSPGVKGVEEGSAPAGCGFRPASSENEEMKTDPGSIENLCPGKASDEPDRALQTSPQPVEGTGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARTHGKKLPPASLKHRDGFEGCSMVPTIYPLETLHNALSLRQVSEFLTKVCQRHTDAHAQASAALFDSMHNHQASDSPFSPPRTLHSPPLQLRHRSEKPPWYSSGPSSTVSSAGPSSPTTVDGNSHFGFSDQSSVNIHMTEEKQGFGLLQETPGDGTRELHIERQQELVEPAQSPQELPVEICPSGSQGVTKVSQTCQEVPDIVQPCHNIHEEIGQPQQEVPDISQLLLKDHDTTTNTCHLCQASQLSQKVCEEICQLCQDNHEESNQLCQEVSVKLGRMVHGFPVNVDSTAQETLMEIGRPTQEIPEDPYQEFSVKVGVLAQKAPAISELSQDIPEADKPSQELSEETELQAQEVSEEIDQESEVVDELPPEAIS", "length": 1415, "header": "sp|A2ARP1-3|VIP1_MOUSE Isoform 3 of Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS=Mus musculus OX=10090 GN=Ppip5k1 PE=1 SV=1 CANONICAL=A2ARP1-1" }, "locus": { "chromosome": "2", "start_pos": 121181104, "end_pos": 121142140, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000110625", "url": "https://www.ensembl.org/id/ENSMUST00000110625" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000106255", "url": "https://www.ensembl.org/id/ENSMUSP00000106255" } ] } }, { "isoform_ac": "A2ARP1-5", "url": "https://www.uniprot.org/uniprot/A2ARP1#A2ARP1-5", "sequence": { "sequence": "MWSLTANEDESTTAHFFLGAGDEGLGTCGIGMRTEESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPSCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPACPEECSLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVMVDAEI", "length": 266, "header": "sp|A2ARP1-5|VIP1_MOUSE Isoform 5 of Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS=Mus musculus OX=10090 GN=Ppip5k1 PE=1 SV=1 CANONICAL=A2ARP1-1" }, "locus": {} }, { "isoform_ac": "A2ARP1-6", "url": "https://www.uniprot.org/uniprot/A2ARP1#A2ARP1-6", "sequence": { "sequence": "MWSLTANEDESTTAHFFLGAGDEGLGTCGIGMRTEESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPSCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPACPEECSLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDHPSFVIEKLVPWRCCLKLHLQDLVATVCFHLHGHQQR", "length": 439, "header": "sp|A2ARP1-6|VIP1_MOUSE Isoform 6 of Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS=Mus musculus OX=10090 GN=Ppip5k1 PE=1 SV=1 CANONICAL=A2ARP1-1" }, "locus": {} }, { "isoform_ac": "A2ARP1-7", "url": "https://www.uniprot.org/uniprot/A2ARP1#A2ARP1-7", "sequence": { "sequence": "MWSLTANEDESTTAHFFLGAGDEGLGTCGIGMRTEESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPSCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPACPEECSLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVTHPRFFALFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPEAEIEEKTGKLEQLKSVLEMYGHFSGINRKVQLTYYPHGVKASNEGQDLQREPLAPSLLLVLKWGGELTPDGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQHRVKARLHHILQQDAPFGPEDYDQVTLFSSPCSNYIATQFLKF", "length": 671, "header": "sp|A2ARP1-7|VIP1_MOUSE Isoform 7 of Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS=Mus musculus OX=10090 GN=Ppip5k1 PE=1 SV=1 CANONICAL=A2ARP1-1" }, "locus": {} }, { "isoform_ac": "B0R0E7-1", "url": "https://www.uniprot.org/uniprot/A2ARP1#B0R0E7-1", "sequence": { "sequence": "MWSLTANEDESTTAHFFLGAGDEGLGTCGIGMRTEESDSELLEDEEDEV", "length": 49, "header": "tr|B0R0E7-1|B0R0E7_MOUSE Computationally mapped isoform of Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS=Mus musculus OX=10090 GN=Ppip5k1 PE=4 SV=1 CANONICAL=A2ARP1-1" }, "locus": { "chromosome": "2", "start_pos": 121181104, "end_pos": 121180958, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000134796", "url": "https://www.ensembl.org/id/ENSMUST00000134796" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000122603", "url": "https://www.ensembl.org/id/ENSMUSP00000122603" } ] } }, { "isoform_ac": "F6Q5C6-1", "url": "https://www.uniprot.org/uniprot/A2ARP1#F6Q5C6-1", "sequence": { "sequence": "LPLLRKILLDLQRTHEDEYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLDETQDAQWQRALAYLSAISELNYMTQIVIMLYEDNTRDPLSEERFHVELHFSPGVKGVEEGSAPAGCGFRPASSENEEMKTDPGSIENLCPGKASDEPDRALQTSPQPVEGTGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARTHGKKLPPASLKHRD", "length": 257, "header": "tr|F6Q5C6-1|F6Q5C6_MOUSE Computationally mapped isoform of Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS=Mus musculus OX=10090 GN=Ppip5k1 PE=1 SV=1 CANONICAL=A2ARP1-1" }, "locus": { "chromosome": "2", "start_pos": 121167640, "end_pos": 121158127, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000155568", "url": "https://www.ensembl.org/id/ENSMUST00000155568" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000116335", "url": "https://www.ensembl.org/id/ENSMUSP00000116335" } ] } }, { "isoform_ac": "F6RMX0-1", "url": "https://www.uniprot.org/uniprot/A2ARP1#F6RMX0-1", "sequence": { "sequence": "XALQTSPQPVEGTGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARTHGKKLPPASLKHRDELLDDQHPVVRLLRTLSSDCPRGWPVSLDATLAHHLHQCSYHLRLFRNWLHSGQDDPECLYGFEGCSMVPTIYPLETLHNALSLRQVSEFLTKVC", "length": 198, "header": "tr|F6RMX0-1|VIP1_MOUSE Computationally mapped isoform of Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS=Mus musculus OX=10090 GN=Ppip5k1 PE=1 SV=1 CANONICAL=A2ARP1-1" }, "locus": { "chromosome": "2", "start_pos": 121164985, "end_pos": 121152172, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000132613", "url": "https://www.ensembl.org/id/ENSMUST00000132613" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000119577", "url": "https://www.ensembl.org/id/ENSMUSP00000119577" } ] } }, { "isoform_ac": "F6VID9-1", "url": "https://www.uniprot.org/uniprot/A2ARP1#F6VID9-1", "sequence": { "sequence": "XLDETQDAQWQRALAYLSAISELNYMTQIVIMLYEDNTRDPLSEERFHVELHFSPGVKGVEEGSAPAGCGFRPASSENEEMKTDPGSIENLCPGKASDEPDRALQTSPQPVEGTGLPRRSPLIRNRKAGSMEVMNMQCTGNLDLIPLRGRRRRRSGDLPRLSPAISLQPRAVSTTHLASCTQVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARTHGKKLPPASLKHRDELLFVPAVKRFSVSFAKHPTNGFEGCSMV", "length": 283, "header": "tr|F6VID9-1|F6VID9_MOUSE Computationally mapped isoform of Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS=Mus musculus OX=10090 GN=Ppip5k1 PE=1 SV=8 CANONICAL=A2ARP1-1" }, "locus": { "chromosome": "2", "start_pos": 121167214, "end_pos": 121152250, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000127255", "url": "https://www.ensembl.org/id/ENSMUST00000127255" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000118597", "url": "https://www.ensembl.org/id/ENSMUSP00000118597" } ] } }, { "isoform_ac": "F6VU93-1", "url": "https://www.uniprot.org/uniprot/A2ARP1#F6VU93-1", "sequence": { "sequence": "XPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKGELWAYSVVLCTCRCTQWGQIMPMLKLESLQLWMGRLNETVRGKRFDIQSC", "length": 118, "header": "tr|F6VU93-1|F6VU93_MOUSE Computationally mapped isoform of Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS=Mus musculus OX=10090 GN=Ppip5k1 PE=4 SV=1 CANONICAL=A2ARP1-1" }, "locus": { "chromosome": "2", "start_pos": 121179272, "end_pos": 121178011, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000137087", "url": "https://www.ensembl.org/id/ENSMUST00000137087" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000115051", "url": "https://www.ensembl.org/id/ENSMUSP00000115051" } ] } }, { "isoform_ac": "F7AST3-1", "url": "https://www.uniprot.org/uniprot/A2ARP1#F7AST3-1", "sequence": { "sequence": "XCLPLLRKILLDLQRTHEDESVNKLHPLYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLDETQDAQWQRALAYLSAISELNYMTQIVIMLYEDNTRDPLSEERFHVELHFSPGVKGVEEGSAPAGCGFRPASSENEEMKTDPGSIENLCPGKASDEPDRALQTSPQPVEGTGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGFEGCSMVPTIYPLETLHNALSLRQVSEFLTKVCQRHTDAHAQASA", "length": 271, "header": "tr|F7AST3-1|F7AST3_MOUSE Computationally mapped isoform of Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS=Mus musculus OX=10090 GN=Ppip5k1 PE=1 SV=1 CANONICAL=A2ARP1-1" }, "locus": { "chromosome": "2", "start_pos": 121167644, "end_pos": 121152136, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000132114", "url": "https://www.ensembl.org/id/ENSMUST00000132114" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000117948", "url": "https://www.ensembl.org/id/ENSMUSP00000117948" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 1032, "end_pos": 1032, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ] }, { "start_pos": 1068, "end_pos": 1068, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ] }, { "start_pos": 1140, "end_pos": 1140, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" }, { "database": "iPTMnet", "id": "A2ARP1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ARP1" }, { "database": "PubMed", "id": "21183079", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079" } ] }, { "start_pos": 1140, "end_pos": 1140, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" }, { "database": "PubMed", "id": "21183079", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079" } ] }, { "start_pos": 1147, "end_pos": 1147, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" }, { "database": "iPTMnet", "id": "A2ARP1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ARP1" }, { "database": "PubMed", "id": "21183079", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079" } ] }, { "start_pos": 1147, "end_pos": 1147, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" }, { "database": "PubMed", "id": "21183079", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079" } ] }, { "start_pos": 939, "end_pos": 939, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ] }, { "start_pos": 982, "end_pos": 982, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ] } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" }, { "database": "iPTMnet", "id": "A2ARP1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ARP1" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079" } ] } ], "pathway": [ { "id": "mmu:327655", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:327655", "resource": "KEGG Pathway" }, { "id": "R-MMU-1855167", "name": "Synthesis of pyrophosphates in the cytosol", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855167", "resource": "Reactome", "description": "Synthesis of pyrophosphates in the cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "P0C644-1", "protein_name": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1", "gene_name": "Ppip5k1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWSLTANEDEDESATAHFFLGAGDEGLGTCGIGMRTGESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPPCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLTMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPACPEECNLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVTHPRFFALFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPGAEIEEKTGKLEQLKSVLEMYGHFSGINRKVQLTYYPHGVKASSEGQDLQREPPAPSLLLVLKWGGELTPDGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQHRVKARLHHILQQDAPFGPEDYDQLAPTGSTSLLNSMSVIQNPVKVCDQVFALIENLTHQIRERMQDPSSVDLQLYHSETLELMLQRWSKLERDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGTAELLRLSKALADVVIPQEYGISREEKVEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLDETKDAQWQRALAYLSAISELNYMTQIVIMLYEDNTRDPLSEERFHVELHFSPGVKGVEEGSAPAGCGFRPASSENEEMKTDPGSIENLCPAKPSDEPDRALQTSPQPVEGTGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARTHGKKLPPAGLKHRDELLFVPAVKRFSVSFAKHPTNGFEGCSMVPTIYPLETLHNALSLRQVSEFLTKVCQRHTDAHAQASAALFDSMHNHQASDNPFSPPRTLHSPPLQLRHRSEKPPWYSSGPSSTVSSAGPSSPTTVDGNSHFGFSDQSSVNTQMIEEKQGLGLLQETPGDGTPEFHIELAESTQSPQEPPVEISPPGSQDDTEVNQTCQEVPDTIQPCHDILEEIGQPNQEVPDISQLLLKNHDTATNTCQPCQASQLSKKVYEEICQLCQDNPEESNQLCQEVSVELGRMVHRFPVSIGSTTQETLMEIGRPTQEIPEEPCQEFSEKVGMLTQKASAISELSQDILETDNPSQELSEETDLQAQEVSEEIDQEPEVVDELSNEDIS", "length": 1434 }, "evidence": [ { "id": "49395", "url": "http://www.informatics.jax.org/homology/49395", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6PFW1-1", "protein_name": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1", "gene_name": "PPIP5K1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWSLTASEGESTTAHFFLGAGDEGLGTRGIGMRPEESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPSCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPARPEECNLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEIRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVKHPRFFALFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPGGEIEEKTGKLEQLKSVLEMYGHFSGINRKVQLTYYPHGVKASNEGQDPQRETLAPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDGDSLSSCQHRVKARLHHILQQDAPFGPEDYDQLAPTRSTSLLNSMTIIQNPVKVCDQVFALIENLTHQIRERMQDPRSVDLQLYHSETLELMLQRWSKLERDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGTAELLRLSKALADVVIPQEYGISREEKLEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLCYLRYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLDETQDAQWQRALDYLSAISELNYMTQIVIMLYEDNTQDPLSEERFHVELHFSPGVKGVEEEGSAPAGCGFRPASSENEEMKTNQGSMENLCPGKASDEPDRALQTSPQPPEGPGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARSHGKKLPPASLKHRDELLFVPAVKRFSVSFAKHPTNGFEGCSMVPTIYPLETLHNALSLRQVSEFLSRVCQRHTDAQAQASAALFDSMHSSQASDNPFSPPRTLHSPPLQLQQRSEKPPWYSSGPSSTVSSAGPSSPTTVDGNSQFGFSDQPSLNSHVAEEHQGLGLLQETPGSGAQELSIEGEQELFEPNQSPQVPPMETSQPYEEVSQPCQEVPDISQPCQDISEALSQPCQKVPDISQQCQENHDNGNHTCQEVPHISQPCQKSSQLCQKVSEEVCQLCLENSEEVSQPCQGVSVEVGKLVHKFHVGVGSLVQETLVEVGSPAEEIPEEVIQPYQEFSVEVGRLAQETSAINLLSQGIPEIDKPSQEFPEEIDLQAQEVPEEIN", "length": 1433 }, "evidence": [ { "id": "49395", "url": "http://www.informatics.jax.org/homology/49395", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 10, "go_terms": [ { "name": "inositol heptakisphosphate kinase activity", "id": "GO:0000829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000829", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ], "pmid": "" }, { "name": "inositol hexakisphosphate kinase activity", "id": "GO:0000828", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000828", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ], "pmid": "17690096" }, { "name": "inositol heptakisphosphate kinase activity", "id": "GO:0000829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000829", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ], "pmid": "21873635" }, { "name": "inositol-1,3,4,5,6-pentakisphosphate kinase activity", "id": "GO:0000827", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000827", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ], "pmid": "" }, { "name": "inositol hexakisphosphate 5-kinase activity", "id": "GO:0000832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000832", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ], "pmid": "" }, { "name": "inositol hexakisphosphate 1-kinase activity", "id": "GO:0052723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052723", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ], "pmid": "" }, { "name": "inositol hexakisphosphate 3-kinase activity", "id": "GO:0052724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052724", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ], "pmid": "" }, { "name": "diphosphoinositol-pentakisphosphate kinase activity", "id": "GO:0033857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033857", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ], "pmid": "" }, { "name": "5-diphosphoinositol pentakisphosphate 3-kinase activity", "id": "GO:0102092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102092", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "inositol metabolic process", "id": "GO:0006020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006020", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ], "pmid": "" }, { "name": "inositol phosphate biosynthetic process", "id": "GO:0032958", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032958", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ], "pmid": "21873635" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A2ARP1", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 684, "end_pos": 686, "annotation": "n_glycosylation_sequon" }, { "start_pos": 749, "end_pos": 751, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10276", "name": "", "equation": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1LPI7-1", "P0C644-1", "O43314-1", "Q6PFW1-1", "A2ARP1-1", "Q6ZQB6-1" ], "evidence": [ { "id": "10276", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10276" } ] }, { "id": "12793", "name": "", "equation": "1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1LPI7-1", "P0C644-1", "Q9ESM0-1", "Q9R0U1-1", "Q92551-1", "Q96PC2-1", "O43314-1", "Q9UHH9-1", "Q6PFW1-1", "A2ARP1-1", "Q6PD10-1", "Q8BWD2-1", "Q6ZQB6-1", "Q80V72-1" ], "evidence": [ { "id": "12793", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12793" } ] }, { "id": "37459", "name": "", "equation": "1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1LPI7-1", "P0C644-1", "O43314-1", "Q6PFW1-1", "A2ARP1-1", "Q6ZQB6-1" ], "evidence": [ { "id": "37459", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/37459" } ] }, { "id": "37467", "name": "", "equation": "1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1LPI7-1", "P0C644-1", "Q9ESM0-1", "Q92551-1", "Q96PC2-1", "O43314-1", "Q6PFW1-1", "A2ARP1-1", "Q6PD10-1", "Q8BWD2-1", "Q6ZQB6-1" ], "evidence": [ { "id": "37467", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/37467" } ] }, { "id": "R-MMU-1855182", "name": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-1629732" ], "enzyme_list": [ "A2ARP1-1", "Q6ZQB6-1" ], "evidence": [ { "id": "R-MMU-1855182", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855182" } ] }, { "id": "R-MMU-1855216", "name": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-1629740" ], "enzyme_list": [ "A2ARP1-1", "Q6ZQB6-1" ], "evidence": [ { "id": "R-MMU-1855216", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855216" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1629732", "participant_name": "1,5-(PP)2-IP4 [cytosol]", "crossref": [ { "id": "62923", "database": "ChEBI", "url": "" }, { "id": "62923", "database": "ChEBI", "url": "" }, { "id": "62923", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1629740", "participant_name": "1-PP-IP5 [cytosol]", "crossref": [ { "id": "62919", "database": "ChEBI", "url": "" }, { "id": "62919", "database": "ChEBI", "url": "" }, { "id": "62919", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A2ARP1", "gene_name": "Ppip5k1", "activity": [ { "ec_number": "2.7.4.21", "activity": "ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.", "evidence": [ { "id": "A2ARP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ] }, { "ec_number": "2.7.4.24", "activity": "ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.", "evidence": [ { "id": "A2ARP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ] }, { "ec_number": "2.7.4.21", "activity": "", "evidence": [ { "id": "A2ARP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ] }, { "ec_number": "2.7.4.24", "activity": "", "evidence": [ { "id": "A2ARP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ARP1" } ] } ] }, { "uniprot_ac": "F1LPI7", "gene_name": "Ppip5k2", "activity": [ { "ec_number": "2.7.4.21", "activity": "ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.", "evidence": [ { "id": "F1LPI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPI7" } ] }, { "ec_number": "2.7.4.24", "activity": "ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.", "evidence": [ { "id": "F1LPI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPI7" } ] }, { "ec_number": "2.7.4.21", "activity": "", "evidence": [ { "id": "F1LPI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPI7" } ] }, { "ec_number": "2.7.4.24", "activity": "", "evidence": [ { "id": "F1LPI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPI7" } ] } ] }, { "uniprot_ac": "O43314", "gene_name": "PPIP5K2", "activity": [ { "ec_number": "2.7.4.21", "activity": "ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.", "evidence": [ { "id": "O43314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43314" } ] }, { "ec_number": "2.7.4.24", "activity": "ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.", "evidence": [ { "id": "O43314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43314" } ] }, { "ec_number": "2.7.4.24", "activity": "", "evidence": [ { "id": "O43314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43314" } ] }, { "ec_number": "2.7.4.21", "activity": "", "evidence": [ { "id": "O43314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43314" } ] } ] }, { "uniprot_ac": "P0C644", "gene_name": "Ppip5k1", "activity": [ { "ec_number": "2.7.4.21", "activity": "ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.", "evidence": [ { "id": "P0C644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C644" } ] }, { "ec_number": "2.7.4.24", "activity": "ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.", "evidence": [ { "id": "P0C644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C644" } ] }, { "ec_number": "2.7.4.21", "activity": "", "evidence": [ { "id": "P0C644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C644" } ] }, { "ec_number": "2.7.4.24", "activity": "", "evidence": [ { "id": "P0C644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C644" } ] } ] }, { "uniprot_ac": "Q6PD10", "gene_name": "Ip6k1", "activity": [ { "ec_number": "2.7.-.-", "activity": "", "evidence": [ { "id": "Q6PD10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PD10" } ] }, { "ec_number": "2.7.4.21", "activity": "ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.", "evidence": [ { "id": "Q6PD10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PD10" } ] }, { "ec_number": "2.7.4.21", "activity": "", "evidence": [ { "id": "Q6PD10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PD10" } ] } ] }, { "uniprot_ac": "Q6PFW1", "gene_name": "PPIP5K1", "activity": [ { "ec_number": "2.7.4.21", "activity": "ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.", "evidence": [ { "id": "Q6PFW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PFW1" } ] }, { "ec_number": "2.7.4.24", "activity": "ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.", "evidence": [ { "id": "Q6PFW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PFW1" } ] }, { "ec_number": "2.7.4.21", "activity": "", "evidence": [ { "id": "Q6PFW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PFW1" } ] }, { "ec_number": "2.7.4.24", "activity": "", "evidence": [ { "id": "Q6PFW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PFW1" } ] } ] }, { "uniprot_ac": "Q6ZQB6", "gene_name": "Ppip5k2", "activity": [ { "ec_number": "2.7.4.21", "activity": "ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.", "evidence": [ { "id": "Q6ZQB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZQB6" } ] }, { "ec_number": "2.7.4.24", "activity": "ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.", "evidence": [ { "id": "Q6ZQB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZQB6" } ] }, { "ec_number": "2.7.4.21", "activity": "", "evidence": [ { "id": "Q6ZQB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZQB6" } ] }, { "ec_number": "2.7.4.24", "activity": "", "evidence": [ { "id": "Q6ZQB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZQB6" } ] } ] }, { "uniprot_ac": "Q80V72", "gene_name": "Ip6k2", "activity": [ { "ec_number": "2.7.-.-", "activity": "", "evidence": [ { "id": "Q80V72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80V72" } ] }, { "ec_number": "2.7.4.-", "activity": "", "evidence": [ { "id": "Q80V72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80V72" } ] } ] }, { "uniprot_ac": "Q8BWD2", "gene_name": "Ip6k3", "activity": [ { "ec_number": "2.7.4.21", "activity": "ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.", "evidence": [ { "id": 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