{
    "uniprot_canonical_ac": "A2APV2-1",
    "uniprot_ac": "A2APV2",
    "uniprot_id": "FMNL2_MOUSE",
    "mass": {
        "chemical_mass": 123101.0,
        "monoisotopic_mass": 123101.0
    },
    "refseq": {
        "ac": "XP_006498398",
        "name": "formin-like protein 2 isoform X7",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006498398"
    },
    "gene_names": [
        {
            "name": "Fmnl2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2APV2",
            "id": "A2APV2"
        },
        {
            "name": "5430425K04Rik; Man",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997",
            "id": "NP_765997"
        },
        {
            "name": "Fmnl2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997",
            "id": "NP_765997"
        },
        {
            "name": "Kiaa1902",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2APV2",
            "id": "A2APV2"
        },
        {
            "name": "Man",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2APV2",
            "id": "A2APV2"
        }
    ],
    "protein_names": [
        {
            "name": "Formin-like protein 2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2APV2#names_and_taxonomy",
            "id": "A2APV2"
        },
        {
            "name": "Formin-like protein 2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2APV2#names_and_taxonomy",
            "id": "A2APV2"
        },
        {
            "name": "Protein Man",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2APV2#names_and_taxonomy",
            "id": "A2APV2"
        },
        {
            "name": "formin-like domain containing protein MAN; protein Man",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997",
            "id": "NP_765997"
        },
        {
            "name": "formin-like protein 2 isoform X7",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006498398",
            "id": "XP_006498398"
        },
        {
            "name": "formin-like protein 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997",
            "id": "NP_765997"
        }
    ],
    "function": [
        {
            "annotation": "Caveolin-1 influences epithelial collective cell migration via FMNL2 formin.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_765997",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997"
                }
            ]
        },
        {
            "annotation": "FMNL1 and FMNL2 are required non-redundantly in the repair of damaged myofibrils.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_765997",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997"
                }
            ]
        },
        {
            "annotation": "Force generation in lamellipodia strongly depends on FMNL formin activity. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_765997",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997"
                }
            ]
        },
        {
            "annotation": "MDia1-FH2 has an effect on the conformation of actin filaments",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_765997",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997"
                }
            ]
        },
        {
            "annotation": "Our data thus link FMNL2/3 formins to actin assembly-dependent functions of Cdc42 in anterograde transport through the Golgi apparatus. Erratum:[Sci Rep. 2019 Nov 26;9(1):18008. PMID: 31767955] Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_765997",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997"
                }
            ]
        },
        {
            "annotation": "Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APV2",
                    "url": "https://www.uniprot.org/uniprot/A2APV2#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APV2",
                    "url": "https://www.uniprot.org/uniprot/A2APV2"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Fmnl2",
            "url": "https://www.uniprot.org/uniprot/A2APV2",
            "locus": {
                "chromosome": "2",
                "start_pos": 52857860,
                "end_pos": 53133804,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000036053",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000036053"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000036053",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000036053",
            "database": "Bgee"
        },
        {
            "id": "71409",
            "url": "https://www.ncbi.nlm.nih.gov/gene/71409",
            "database": "GeneID"
        },
        {
            "id": "A2APV2",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A2APV2*",
            "database": "IntAct"
        },
        {
            "id": "IPR010472",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR010472",
            "database": "InterPro"
        },
        {
            "id": "IPR010473",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR010473",
            "database": "InterPro"
        },
        {
            "id": "IPR011989",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989",
            "database": "InterPro"
        },
        {
            "id": "IPR014767",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR014767",
            "database": "InterPro"
        },
        {
            "id": "IPR014768",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR014768",
            "database": "InterPro"
        },
        {
            "id": "IPR015425",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015425",
            "database": "InterPro"
        },
        {
            "id": "IPR016024",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024",
            "database": "InterPro"
        },
        {
            "id": "IPR027656",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027656",
            "database": "InterPro"
        },
        {
            "id": "IPR042201",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR042201",
            "database": "InterPro"
        },
        {
            "id": "IPR043592",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR043592",
            "database": "InterPro"
        },
        {
            "id": "mmu:71409",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:71409",
            "database": "KEGG Pathway"
        },
        {
            "id": "1918659",
            "url": "http://www.informatics.jax.org/marker/MGI:1918659",
            "database": "MGI"
        },
        {
            "id": "MMPGFSP",
            "url": "https://omabrowser.org/oma/group/MMPGFSP/",
            "database": "OMA"
        },
        {
            "id": "288325at2759",
            "url": "http://www.orthodb.org/?query=288325at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PTHR45857",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45857",
            "database": "PANTHER"
        },
        {
            "id": "PTHR45857:SF5",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45857:SF5",
            "database": "PANTHER"
        },
        {
            "id": "PF02181",
            "url": "http://pfam.xfam.org/family/PF02181",
            "database": "Pfam"
        },
        {
            "id": "PF06367",
            "url": "http://pfam.xfam.org/family/PF06367",
            "database": "Pfam"
        },
        {
            "id": "PF06371",
            "url": "http://pfam.xfam.org/family/PF06371",
            "database": "Pfam"
        },
        {
            "id": "PR_A2APV2",
            "url": "http://purl.obolibrary.org/obo/PR_PR_A2APV2",
            "database": "PRO"
        },
        {
            "id": "R-MMU-5663220",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5663220",
            "database": "Reactome"
        },
        {
            "id": "R-MMU-9013106",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013106",
            "database": "Reactome"
        },
        {
            "id": "R-MMU-9013148",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013148",
            "database": "Reactome"
        },
        {
            "id": "NP_765997",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997",
            "database": "RefSeq"
        },
        {
            "id": "XP_006498398",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006498398",
            "database": "RefSeq"
        },
        {
            "id": "A2APV2",
            "url": "https://www.uniprot.org/uniprot/A2APV2",
            "database": "UniProtKB"
        },
        {
            "id": "A2APV2-1",
            "url": "https://www.uniprot.org/uniprot/A2APV2-1",
            "database": "UniProtKB"
        },
        {
            "id": "A2APV2-2",
            "url": "https://www.uniprot.org/uniprot/A2APV2-2",
            "database": "UniProtKB"
        },
        {
            "id": "A2APV2-3",
            "url": "https://www.uniprot.org/uniprot/A2APV2-3",
            "database": "UniProtKB"
        },
        {
            "id": "A2AQW2",
            "url": "https://www.uniprot.org/uniprot/A2AQW2",
            "database": "UniProtKB"
        },
        {
            "id": "A2AQW2-1",
            "url": "https://www.uniprot.org/uniprot/A2AQW2-1",
            "database": "UniProtKB"
        },
        {
            "id": "E9PXE6",
            "url": "https://www.uniprot.org/uniprot/E9PXE6",
            "database": "UniProtKB"
        },
        {
            "id": "E9PXE6-1",
            "url": "https://www.uniprot.org/uniprot/E9PXE6-1",
            "database": "UniProtKB"
        },
        {
            "id": "F8VPR2",
            "url": "https://www.uniprot.org/uniprot/F8VPR2",
            "database": "UniProtKB"
        },
        {
            "id": "F8VPR2-1",
            "url": "https://www.uniprot.org/uniprot/F8VPR2-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MGNAGSMDSQQTDFKAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTMESTVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVMASGTLSTGSELAVGNYVGSVPGATTSGPSVPPPPPLPPSSDTSEAAQNGTASPPMSPPPPPPPPPPPPPPPPPPLPGPAAETSPAPPLPPPPPPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKITQKASSKVTLLEANRAKNLAITLRKAGKSADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLLQKMTIMAFIGNFTESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYQQVTLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFLLHNEGKLKKLQEDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDAKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITALKKNNITKFPNVHSRVRISSSTPVVEDTQS",
        "length": 1086,
        "header": "sp|A2APV2-1|FMNL2_MOUSE Isoform 1 of Formin-like protein 2  OS=Mus musculus OX=10090 GN=Fmnl2 PE=1 SV=2 CANONICAL=A2APV2-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2APV2-1",
            "url": "https://www.uniprot.org/uniprot/A2APV2#A2APV2-1",
            "sequence": {
                "sequence": "MGNAGSMDSQQTDFKAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTMESTVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVMASGTLSTGSELAVGNYVGSVPGATTSGPSVPPPPPLPPSSDTSEAAQNGTASPPMSPPPPPPPPPPPPPPPPPPLPGPAAETSPAPPLPPPPPPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKITQKASSKVTLLEANRAKNLAITLRKAGKSADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLLQKMTIMAFIGNFTESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYQQVTLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFLLHNEGKLKKLQEDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDAKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITALKKNNITKFPNVHSRVRISSSTPVVEDTQS",
                "length": 1086,
                "header": "sp|A2APV2-1|FMNL2_MOUSE Isoform 1 of Formin-like protein 2  OS=Mus musculus OX=10090 GN=Fmnl2 PE=1 SV=2 CANONICAL=A2APV2-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 53020517,
                "end_pos": 52748155,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000127122",
                        "url": "https://www.ensembl.org/id/ENSMUST00000127122"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000118658",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000118658"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A2APV2-2",
            "url": "https://www.uniprot.org/uniprot/A2APV2#A2APV2-2",
            "sequence": {
                "sequence": "MGNAGSMDSQQTDFKAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTMESTVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVMASGTLSTGSELAVGNYVGSVPGATTSGPSVPPPPPLPPSSDTSEAAQNGTASPPMSPPPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKITQKASSKVTLLEANRAKNLAITLRKAGKSADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLLQKMTIMAFIGNFTESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYQQVTLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFLLHNEGKLKKLQEDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDAKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITVLETNPTDEPMR",
                "length": 1032,
                "header": "sp|A2APV2-2|FMNL2_MOUSE Isoform 2 of Formin-like protein 2  OS=Mus musculus OX=10090 GN=Fmnl2 PE=1 SV=2 CANONICAL=A2APV2-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "A2APV2-3",
            "url": "https://www.uniprot.org/uniprot/A2APV2#A2APV2-3",
            "sequence": {
                "sequence": "MGNAGSMDSQQTDFKAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTMESTVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVMASGTLSTGSELAVGNYVGSVPGATTSGPSVPPPPPLPPSSDTSEAAQNGTASPPMSPPPPPPPPPPPPPPPPPPLPGPAAETSPAPPLPPPPPPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKITQKASSKVTLLEANRAKNLAITLRKAGKSADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLLQKMTIMAFIGNFTESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYQQVTLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFLLHNEGKLKKLQEDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDAKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITDLRNQPYRRADAVRRSVRRRFDDQNLRSVNGAEITM",
                "length": 1091,
                "header": "sp|A2APV2-3|FMNL2_MOUSE Isoform 3 of Formin-like protein 2  OS=Mus musculus OX=10090 GN=Fmnl2 PE=1 SV=2 CANONICAL=A2APV2-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 53021958,
                "end_pos": 52748155,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000090952",
                        "url": "https://www.ensembl.org/id/ENSMUST00000090952"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000088472",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000088472"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A2AQW2-1",
            "url": "https://www.uniprot.org/uniprot/A2APV2#A2AQW2-1",
            "sequence": {
                "sequence": "MGNAGSMDSQQTDFKAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTMESTVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVMASGTLSTGSELAVGNYVGSVPGATTSGPSVPPPPPLPPSSDTSEAAQNGTASPPMSPPPPPPPPPPPPPPPPPPLPGPAAETSPAPPLPPPPPPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKITQKASSKVTLLEANRAKNLAITLRKAGKSADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLLQKMTIMAFIGNFTESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYQQVTLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFLLHNEGKLKKLQEDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDAKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITVLKTVPFTARTAKRGSRFFCEPVLTEEYHY",
                "length": 1085,
                "header": "tr|A2AQW2-1|A2AQW2_MOUSE Computationally mapped isoform of Formin-like protein 2  OS=Mus musculus OX=10090 GN=Fmnl2 PE=1 SV=2 CANONICAL=A2APV2-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 53018817,
                "end_pos": 52748155,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000155586",
                        "url": "https://www.ensembl.org/id/ENSMUST00000155586"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000117822",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000117822"
                    }
                ]
            }
        },
        {
            "isoform_ac": "E9PXE6-1",
            "url": "https://www.uniprot.org/uniprot/A2APV2#E9PXE6-1",
            "sequence": {
                "sequence": "MGNAGSMDSQQTDFKAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTMESTVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVMASGTLSTGSELAVGNYVGSVPGATTSGPSVPPPPPLPPSSDTSEAAQNGTASPPMSPPPPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKITQKASSKVTLLEANRAKNLAITLRKAGKSADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLLQKMTIMAFIGNFTESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYQQVTLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFLLHNEGKLKKLQEDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDAKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITEILETNPTDEPMR",
                "length": 1034,
                "header": "tr|E9PXE6-1|E9PXE6_MOUSE Computationally mapped isoform of Formin-like protein 2  OS=Mus musculus OX=10090 GN=Fmnl2 PE=1 SV=2 CANONICAL=A2APV2-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 53021887,
                "end_pos": 52748155,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000050719",
                        "url": "https://www.ensembl.org/id/ENSMUST00000050719"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000057084",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000057084"
                    }
                ]
            }
        },
        {
            "isoform_ac": "F8VPR2-1",
            "url": "https://www.uniprot.org/uniprot/A2APV2#F8VPR2-1",
            "sequence": {
                "sequence": "MGNAGSMDSQQTDFKAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTMESTVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVMASGTLSTGSELAVGNYVGSVPGATTSGPSVPPPPPLPPSSDTSEAAQNGTASPPMSPPPPPPPPPPPPPPPPPPLPGPAAETSPAPPLPPPPPPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKITQKASSKVTLLEANRAKNLAITLRKAGKSADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLLQKMTIMAFIGNFTESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYQQVTLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFLLHNEGKLKKLQEDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDAKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITALKKNNITKFPNVHSRILETNPTDEPMR",
                "length": 1083,
                "header": "tr|F8VPR2-1|F8VPR2_MOUSE Computationally mapped isoform of Formin-like protein 2  OS=Mus musculus OX=10090 GN=Fmnl2 PE=1 SV=1 CANONICAL=A2APV2-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 53021887,
                "end_pos": 52748155,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000049483",
                        "url": "https://www.ensembl.org/id/ENSMUST00000049483"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000047260",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000047260"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 188,
            "end_pos": 188,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APV2",
                    "url": "https://www.uniprot.org/uniprot/A2APV2"
                }
            ]
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Formins regulate actin filament flexibility through long range allosteric interactions.",
            "journal": "The Journal of biological chemistry",
            "date": "2006",
            "authors": "Bugyi B, Papp G, Hild G, Lorinczy D, Nevalainen EM, Lappalainen P, Somogyi B, Nyitrai M",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_765997",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16490788",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/16490788"
                }
            ]
        },
        {
            "title": "Critical roles for multiple formins during cardiac myofibril development and repair.",
            "journal": "Molecular biology of the cell",
            "date": "2014",
            "authors": "Rosado M, Barber CF, Berciu C, Feldman S, Birren SJ, Nicastro D, Goode BL",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_765997",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "24430873",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24430873"
                }
            ]
        },
        {
            "title": "FMNL formins boost lamellipodial force generation.",
            "journal": "Nature communications",
            "date": "2017",
            "authors": "Kage F, Winterhoff M, Dimchev V, Mueller J, Thalheim T, Freise A, Bruhmann S, Kollasser J, Block J, Dimchev G, Geyer M, Schnittler HJ, Brakebusch C, Stradal TE, Carlier MF, Sixt M, Kas J, Faix J, Rottner K",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_765997",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "28327544",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/28327544"
                }
            ]
        },
        {
            "title": "FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42.",
            "journal": "Scientific reports",
            "date": "2017",
            "authors": "Kage F, Steffen A, Ellinger A, Ranftler C, Gehre C, Brakebusch C, Pavelka M, Stradal T, Rottner K",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_765997",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "28852060",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/28852060"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:71409",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:71409",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-5663220",
            "name": "RHO GTPases Activate Formins",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5663220",
            "resource": "Reactome",
            "description": "RHO GTPases Activate Formins"
        },
        {
            "id": "R-MMU-9013106",
            "name": "RHOC GTPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013106",
            "resource": "Reactome",
            "description": "RHOC GTPase cycle"
        },
        {
            "id": "R-MMU-9013148",
            "name": "CDC42 GTPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013148",
            "resource": "Reactome",
            "description": "CDC42 GTPase cycle"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q96PY5-1",
            "protein_name": "Formin-like protein 2",
            "gene_name": "FMNL2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MGNAGSMDSQQTDFRAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTVESSVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDPKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITVLKTVPFTARTAKRGSRFFCEPVLTEEYHY",
                "length": 1086
            },
            "evidence": [
                {
                    "id": "70871",
                    "url": "http://www.informatics.jax.org/homology/70871",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APV2",
                                "url": "https://www.uniprot.org/uniprot/A2APV2"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 6,
                "go_terms": [
                    {
                        "name": "cell migration",
                        "id": "GO:0016477",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APV2",
                                "url": "https://www.uniprot.org/uniprot/A2APV2"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "cytoskeleton organization",
                        "id": "GO:0007010",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APV2",
                                "url": "https://www.uniprot.org/uniprot/A2APV2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of cell shape",
                        "id": "GO:0008360",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008360",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APV2",
                                "url": "https://www.uniprot.org/uniprot/A2APV2"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "cortical actin cytoskeleton organization",
                        "id": "GO:0030866",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030866",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APV2",
                                "url": "https://www.uniprot.org/uniprot/A2APV2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of cell morphogenesis",
                        "id": "GO:0022604",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022604",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APV2",
                                "url": "https://www.uniprot.org/uniprot/A2APV2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "actin cytoskeleton organization",
                        "id": "GO:0030036",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APV2",
                                "url": "https://www.uniprot.org/uniprot/A2APV2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "actin filament binding",
                        "id": "GO:0051015",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APV2",
                                "url": "https://www.uniprot.org/uniprot/A2APV2"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "small GTPase binding",
                        "id": "GO:0031267",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APV2",
                                "url": "https://www.uniprot.org/uniprot/A2APV2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "actin binding",
                        "id": "GO:0003779",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APV2",
                                "url": "https://www.uniprot.org/uniprot/A2APV2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 1061,
            "end_pos": 1063,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 401,
            "end_pos": 403,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 545,
            "end_pos": 547,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 639,
            "end_pos": 641,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 760,
            "end_pos": 762,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 789,
            "end_pos": 791,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 832,
            "end_pos": 834,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ]
}