{
    "uniprot_canonical_ac": "A2AMM0-1",
    "uniprot_ac": "A2AMM0",
    "uniprot_id": "CAVN4_MOUSE",
    "mass": {
        "chemical_mass": 41008.0,
        "monoisotopic_mass": 41008.0
    },
    "refseq": {
        "ac": "NP_080785",
        "name": "caveolae-associated protein 4",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
    },
    "gene_names": [
        {
            "name": "Cavin4",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AMM0",
            "id": "A2AMM0"
        },
        {
            "name": "2310039E09Rik; Murc",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785",
            "id": "NP_080785"
        },
        {
            "name": "Cavin4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785",
            "id": "NP_080785"
        },
        {
            "name": "Murc",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AMM0",
            "id": "A2AMM0"
        }
    ],
    "protein_names": [
        {
            "name": "Caveolae-associated protein 4",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AMM0#names_and_taxonomy",
            "id": "A2AMM0"
        },
        {
            "name": "Muscle-related coiled-coil protein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AMM0#names_and_taxonomy",
            "id": "A2AMM0"
        },
        {
            "name": "Muscle-restricted coiled-coil protein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AMM0#names_and_taxonomy",
            "id": "A2AMM0"
        },
        {
            "name": "caveolae-associated protein 4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785",
            "id": "NP_080785"
        },
        {
            "name": "muscle-restricted coiled-coil protein; cavin 4; muscle-related coiled-coil protein",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785",
            "id": "NP_080785"
        }
    ],
    "function": [
        {
            "annotation": "Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ]
        },
        {
            "annotation": "Data show that MURC/Cavin-4 forms a multiprotein complex that associates with caveolae, and identify Cavin-4 as a novel muscle disease candidate caveolar protein.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ]
        },
        {
            "annotation": "Findings suggest that MURC is involved in the skeletal myogenesis that results from modulation of myogenin expression and ERK activation; MURC may play pivotal roles in the molecular mechanisms of skeletal myogenic differentiation",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ]
        },
        {
            "annotation": "MURC binds to Cav1 and inhibits the association of Cav1 with the active form of Galpha13, resulting in the facilitated association of the active form of Galpha13 with p115RhoGEF. These results reveal that MURC has a function in the development of pulmonary hypertension through modulating Rho/ROCK signaling. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ]
        },
        {
            "annotation": "MURC modulates RhoA signaling, and MURC plays an important role in the development of cardiac dysfunction and conduction disturbance with increased vulnerability to atrial arrhythmias.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ]
        },
        {
            "annotation": "MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by alpha1-adrenergic receptors.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ]
        },
        {
            "annotation": "Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation (PubMed:24567387). Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (PubMed:26497963). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0#function"
                }
            ]
        },
        {
            "annotation": "Systems Network Genomic Analysis Reveals Cardioprotective Effect of MURC/Cavin-4 Deletion Against Ischemia/Reperfusion Injury.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ]
        },
        {
            "annotation": "The MURC/Cavin-4 in vascular smooth muscle cells modulates abdominal aortic aneurysm (AAA) progression at the early stage via the activation of JNK and MMP-9. MURC/Cavin-4 is a potential therapeutic target against AAA progression.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:9884",
            "recommended_name": {
                "id": "DOID:9884",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:9884",
                "name": "muscular dystrophy",
                "description": "A myopathy is characterized by progressive skeletal muscle weakness degeneration."
            },
            "synonyms": [
                {
                    "id": "MONDO:0010884",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010884",
                    "name": "muscular dystrophy, scapulohumeral",
                    "description": ""
                },
                {
                    "id": "MONDO:0010884",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010884",
                    "name": "muscular dystrophy, scapulohumeral",
                    "description": ""
                },
                {
                    "id": "MONDO:0010676",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010676",
                    "name": "muscular dystrophy, Hemizygous lethal type",
                    "description": ""
                },
                {
                    "id": "MONDO:0010676",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010676",
                    "name": "muscular dystrophy, Hemizygous lethal type",
                    "description": ""
                },
                {
                    "id": "MONDO:0010675",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010675",
                    "name": "muscular dystrophy, cardiac type",
                    "description": ""
                },
                {
                    "id": "MONDO:0010675",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010675",
                    "name": "muscular dystrophy, cardiac type",
                    "description": ""
                },
                {
                    "id": "MONDO:0010678",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010678",
                    "name": "muscular dystrophy, progressive Pectorodorsal",
                    "description": ""
                },
                {
                    "id": "MONDO:0010678",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010678",
                    "name": "muscular dystrophy, progressive Pectorodorsal",
                    "description": ""
                },
                {
                    "id": "MONDO:0010678",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010678",
                    "name": "muscular dystrophy, progressive, involving shoulder girdle and back",
                    "description": ""
                },
                {
                    "id": "MONDO:0010677",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010677",
                    "name": "muscular dystrophy, Mabry type",
                    "description": ""
                },
                {
                    "id": "MONDO:0010677",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010677",
                    "name": "muscular dystrophy, Mabry type",
                    "description": ""
                },
                {
                    "id": "MONDO:0008028",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008028",
                    "name": "muscular dystrophy, Barnes type",
                    "description": ""
                },
                {
                    "id": "MONDO:0008028",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008028",
                    "name": "muscular dystrophy, Barnes type",
                    "description": ""
                },
                {
                    "id": "MONDO:0008034",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008034",
                    "name": "muscular dystrophy, pseudohypertrophic, with Internalized capillaries",
                    "description": ""
                },
                {
                    "id": "MONDO:0008034",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008034",
                    "name": "muscular dystrophy, pseudohypertrophic, with Internalized capillaries",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "9884",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/gene/9884#disease-associations"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Cavin4",
            "url": "https://www.uniprot.org/uniprot/A2AMM0",
            "locus": {
                "chromosome": "4",
                "start_pos": 48663514,
                "end_pos": 48673502,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000028348",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000028348"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000028348",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000028348",
            "database": "Bgee"
        },
        {
            "id": "68016",
            "url": "https://www.ncbi.nlm.nih.gov/gene/68016",
            "database": "GeneID"
        },
        {
            "id": "A2AMM0",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AMM0*",
            "database": "IntAct"
        },
        {
            "id": "IPR026752",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR026752",
            "database": "InterPro"
        },
        {
            "id": "IPR033299",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR033299",
            "database": "InterPro"
        },
        {
            "id": "mmu:68016",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68016",
            "database": "KEGG Pathway"
        },
        {
            "id": "1915266",
            "url": "http://www.informatics.jax.org/marker/MGI:1915266",
            "database": "MGI"
        },
        {
            "id": "GQEGIQE",
            "url": "https://omabrowser.org/oma/group/GQEGIQE/",
            "database": "OMA"
        },
        {
            "id": "991901at2759",
            "url": "http://www.orthodb.org/?query=991901at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PTHR15240",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15240",
            "database": "PANTHER"
        },
        {
            "id": "PTHR15240:SF4",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15240:SF4",
            "database": "PANTHER"
        },
        {
            "id": "PF15237",
            "url": "http://pfam.xfam.org/family/PF15237",
            "database": "Pfam"
        },
        {
            "id": "PR_A2AMM0",
            "url": "http://purl.obolibrary.org/obo/PR_PR_A2AMM0",
            "database": "PRO"
        },
        {
            "id": "NP_080785",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785",
            "database": "RefSeq"
        },
        {
            "id": "A2AMM0",
            "url": "https://www.uniprot.org/uniprot/A2AMM0",
            "database": "UniProtKB"
        },
        {
            "id": "A2AMM0-1",
            "url": "https://www.uniprot.org/uniprot/A2AMM0-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MEHNGSASNAGKIHQNRLSSVTEDEDQDAALTIVTVLDRVASVVDSVQASQKRIEERHREMGNAIKSVQIDLLKLSQSHSNTGYVVNKLFEKTRKVSAHIKDVKARVEKQQVRVTKVETKQEEIMKKNKFRVVIFQEDIPCPASLSVVKDRSLPENQEEAEEVFDPPIELSSDEEYYVEESRSARLRKSGKEHIDHIKKAFSRENMQKTRQTLDKKVSGIRTRIVTPERRERLRQSGERLRQSGERLRQSGERFKKSISSAAPSKEAFKIRSLRKAKDPKAEGQEVDRGMGVDIISGSLALGPIHEFHSDEFSETEKEVTKGGYSPQEGGDPPTPEPLKVTFKPQVRVEDDESLLLELKQSS",
        "length": 362,
        "header": "sp|A2AMM0-1|CAVN4_MOUSE Isoform 1 of Caveolae-associated protein 4  OS=Mus musculus OX=10090 GN=Cavin4 PE=1 SV=1 CANONICAL=A2AMM0-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2AMM0-1",
            "url": "https://www.uniprot.org/uniprot/A2AMM0#A2AMM0-1",
            "sequence": {
                "sequence": "MEHNGSASNAGKIHQNRLSSVTEDEDQDAALTIVTVLDRVASVVDSVQASQKRIEERHREMGNAIKSVQIDLLKLSQSHSNTGYVVNKLFEKTRKVSAHIKDVKARVEKQQVRVTKVETKQEEIMKKNKFRVVIFQEDIPCPASLSVVKDRSLPENQEEAEEVFDPPIELSSDEEYYVEESRSARLRKSGKEHIDHIKKAFSRENMQKTRQTLDKKVSGIRTRIVTPERRERLRQSGERLRQSGERLRQSGERFKKSISSAAPSKEAFKIRSLRKAKDPKAEGQEVDRGMGVDIISGSLALGPIHEFHSDEFSETEKEVTKGGYSPQEGGDPPTPEPLKVTFKPQVRVEDDESLLLELKQSS",
                "length": 362,
                "header": "sp|A2AMM0-1|CAVN4_MOUSE Isoform 1 of Caveolae-associated protein 4  OS=Mus musculus OX=10090 GN=Cavin4 PE=1 SV=1 CANONICAL=A2AMM0-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 48672642,
                "end_pos": 48663622,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000030033",
                        "url": "https://www.ensembl.org/id/ENSMUST00000030033"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000030033",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000030033"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 152,
            "end_pos": 152,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                }
            ]
        },
        {
            "start_pos": 171,
            "end_pos": 171,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                }
            ]
        },
        {
            "start_pos": 172,
            "end_pos": 172,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                }
            ]
        },
        {
            "start_pos": 324,
            "end_pos": 324,
            "kinase_uniprot_canonical_ac": "Q3UD01-1",
            "kinase_gene_name": "Atxn7l3b",
            "residue": "Tyr",
            "comment": "",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                },
                {
                    "database": "iPTMnet",
                    "id": "A2AMM0",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AMM0"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079"
                }
            ]
        },
        {
            "start_pos": 324,
            "end_pos": 324,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079"
                }
            ]
        },
        {
            "start_pos": 334,
            "end_pos": 334,
            "kinase_uniprot_canonical_ac": "Q3UD01-1",
            "kinase_gene_name": "Atxn7l3b",
            "residue": "Thr",
            "comment": "",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                },
                {
                    "database": "iPTMnet",
                    "id": "A2AMM0",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AMM0"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079"
                }
            ]
        },
        {
            "start_pos": 334,
            "end_pos": 334,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079"
                }
            ]
        },
        {
            "start_pos": 353,
            "end_pos": 353,
            "kinase_uniprot_canonical_ac": "Q3UD01-1",
            "kinase_gene_name": "Atxn7l3b",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                },
                {
                    "database": "iPTMnet",
                    "id": "A2AMM0",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AMM0"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079"
                }
            ]
        },
        {
            "start_pos": 353,
            "end_pos": 353,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079"
                }
            ]
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance.",
            "journal": "Mol. Cell. Biol.",
            "date": "2008",
            "authors": "Takahashi T., Ogata T., Oh H., Ueyama T., Harada K., Kawashima T., Isodono K., Matsubara H., Shioi T., Tagawa M., Takehara N.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18332105",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/18332105"
                }
            ]
        },
        {
            "title": "MURC, a muscle-restricted coiled-coil protein, is involved in the regulation of skeletal myogenesis.",
            "journal": "American journal of physiology. Cell physiology",
            "date": "2008",
            "authors": "Tagawa M, Ueyama T, Ogata T, Takehara N, Nakajima N, Isodono K, Asada S, Takahashi T, Matsubara H, Oh H",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18508909",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/18508909"
                }
            ]
        },
        {
            "title": "MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes.",
            "journal": "J. Cell Biol.",
            "date": "2009",
            "authors": "Gygi S.P., Liu L., North K.N., Parton R.G., Hill M.M., Abankwa D., Bastiani M., Hancock J.F., Luetterforst R., Nixon S.J., Pilch P.F., Jedrychowski M.P., Breen M.R., Fernandez-Rojo M., Lo H.P., Vinten J., Walser P.J.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19546242",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/19546242"
                }
            ]
        },
        {
            "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.",
            "journal": "Cell",
            "date": "2010",
            "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                },
                {
                    "database": "iPTMnet",
                    "id": "A2AMM0",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AMM0"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21183079",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079"
                }
            ]
        },
        {
            "title": "MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by alpha1-adrenergic receptors.",
            "journal": "Proc. Natl. Acad. Sci. U.S.A.",
            "date": "2014",
            "authors": "Yamada H., Taniguchi T., Hamaoka T., Hayashi Y.K., Ikeda K., Maruyama N., Matoba S., Miyagawa K., Naito D., Nakanishi N., Ogata T., Oh H., Ueyama T.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "24567387",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24567387"
                }
            ]
        },
        {
            "title": "The coiled-coil domain of MURC/cavin-4 is involved in membrane trafficking of caveolin-3 in cardiomyocytes.",
            "journal": "Am. J. Physiol.",
            "date": "2015",
            "authors": "Taniguchi T., Hamaoka T., Maruyama N., Matoba S., Miyagawa K., Naito D., Nakanishi N., Ogata T., Ueyama T., Nishi M., Kasahara T.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26497963",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/26497963"
                }
            ]
        },
        {
            "title": "MURC deficiency in smooth muscle attenuates pulmonary hypertension.",
            "journal": "Nature communications",
            "date": "2016",
            "authors": "Nakanishi N, Ogata T, Naito D, Miyagawa K, Taniguchi T, Hamaoka T, Maruyama N, Kasahara T, Nishi M, Matoba S, Ueyama T",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27546070",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/27546070"
                }
            ]
        },
        {
            "title": "Loss of MURC/Cavin-4 induces JNK and MMP-9 activity enhancement in vascular smooth muscle cells and exacerbates abdominal aortic aneurysm.",
            "journal": "Biochemical and biophysical research communications",
            "date": "2017",
            "authors": "Miyagawa K, Ogata T, Ueyama T, Kasahara T, Nakanishi N, Naito D, Taniguchi T, Hamaoka T, Maruyama N, Nishi M, Kimura T, Yamada H, Aoki H, Matoba S",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "28433630",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/28433630"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:68016",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68016",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "B1PRL5-1",
            "protein_name": "Caveolae-associated protein 4",
            "gene_name": "Cavin4",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MEHNGSASNAGKIHQNRLSSVTEDEDQDAALTIVTVLDRVATVVDSVQASQKRIEERHREMGNAIKSVQIDLLKLSQSHSNTGYVVNKLFEKTRKVSAHIKDVKARVEKQQVRVTKVETKQEEIMKKNKFRVVIFQEDVPCPASLSVVKDRSLPENEEEAEEVFDPPIDLSSDEEYYVEESRSARLRKSGKEHIDHIKKAFSKENMQKTRQNFDKKVSGIRTRIVTPERRERLRQSGERLRQSGERLRQSGERFKKSISNATPSKEAFKIRSLRKPKDPKAEGQEVDRGMGVDIISGSLALGPIHEFHSDGFSETEKEVTKVGYIPQEGGDPPTPEPLKVTFKPQVRVEDDESLLLELKQSS",
                "length": 362
            },
            "evidence": [
                {
                    "id": "12224",
                    "url": "http://www.informatics.jax.org/homology/12224",
                    "database": "MGI"
                },
                {
                    "id": "A2AMM0",
                    "url": "https://omabrowser.org/oma/group/A2AMM0/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q5BKX8-1",
            "protein_name": "Caveolae-associated protein 4",
            "gene_name": "CAVIN4",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MEHNGSASNADKIHQNRLSSVTEDEDQDAALTIVTVLDKVASIVDSVQASQKRIEERHREMENAIKSVQIDLLKLSQSHSNTGHIINKLFEKTRKVSAHIKDVKARVEKQQIHVKKVEVKQEEIMKKNKFRVVIFQEKFRCPTSLSVVKDRNLTENQEEDDDDIFDPPVDLSSDEEYYVEESRSARLRKSGKEHIDNIKKAFSKENMQKTRQNLDKKVNRIRTRIVTPERRERLRQSGERLRQSGERLRQSGERFKKSISNAAPSKEAFKMRSLRKGKDRTVAEGEECAREMGVDIIARSESLGPISELYSDELSEPEHEAARPVYPPHEGREIPTPEPLKVTFKSQVKVEDDESLLLDLKHSS",
                "length": 364
            },
            "evidence": [
                {
                    "id": "12224",
                    "url": "http://www.informatics.jax.org/homology/12224",
                    "database": "MGI"
                },
                {
                    "id": "A2AMM0",
                    "url": "https://omabrowser.org/oma/group/A2AMM0/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "GTPase activator activity",
                        "id": "GO:0005096",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": "18332105"
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 7,
                "go_terms": [
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": "18332105"
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": "26497963"
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": "24567387"
                    },
                    {
                        "name": "caveola",
                        "id": "GO:0005901",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005901",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": "24567387"
                    },
                    {
                        "name": "sarcolemma",
                        "id": "GO:0042383",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Z disc",
                        "id": "GO:0030018",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": "18332105"
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 6,
                "go_terms": [
                    {
                        "name": "positive regulation of transcription by RNA polymerase II",
                        "id": "GO:0045944",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": "18332105"
                    },
                    {
                        "name": "Rho protein signal transduction",
                        "id": "GO:0007266",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007266",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": "18332105"
                    },
                    {
                        "name": "muscle organ development",
                        "id": "GO:0007517",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007517",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of Rho protein signal transduction",
                        "id": "GO:0035023",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035023",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cardiac myofibril assembly",
                        "id": "GO:0055003",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055003",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": "18332105"
                    },
                    {
                        "name": "regulation of gene expression",
                        "id": "GO:0010468",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 4,
            "end_pos": 6,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ]
}