{ "uniprot_canonical_ac": "A2AI05-1", "uniprot_ac": "A2AI05", "uniprot_id": "NDOR1_MOUSE", "mass": { "chemical_mass": 67183.0, "monoisotopic_mass": 67183.0 }, "refseq": { "ac": "NP_001239471", "name": "NADPH-dependent diflavin oxidoreductase 1 isoform 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239471" }, "gene_names": [ { "name": "Ndor1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AI05", "id": "A2AI05" }, { "name": "4930447P04Rik; Ndor; NR1; Tg(UBC-cre/ERT2)1Ejb; Ubc-cre", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239471", "id": "NP_001239471" }, { "name": "Ndor1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239471", "id": "NP_001239471" } ], "protein_names": [ { "name": "NADPH-dependent diflavin oxidoreductase 1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AI05#names_and_taxonomy", "id": "A2AI05" }, { "name": "1.18.1.-", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AI05#names_and_taxonomy", "id": "A2AI05" }, { "name": "NADPH-dependent FMN and FAD-containing oxidoreductase; Tg(UBC-cre)1Ejb; Tg(UBC-cre/ESR1)1Ejb", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075945", "id": "NP_001075945" }, { "name": "NADPH-dependent FMN and FAD-containing oxidoreductase", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AI05#names_and_taxonomy", "id": "A2AI05" }, { "name": "NADPH-dependent diflavin oxidoreductase 1 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075945", "id": "NP_001075945" }, { "name": "NADPH-dependent diflavin oxidoreductase 1 isoform 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239471", "id": "NP_001239471" }, { "name": "NADPH-dependent diflavin oxidoreductase 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AI05#names_and_taxonomy", "id": "A2AI05" } ], "function": [ { "annotation": "NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair (By similarity). In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Ndor1", "url": "https://www.uniprot.org/uniprot/A2AI05", "locus": { "chromosome": "2", "start_pos": 25255386, "end_pos": 25244863, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000115074", "url": "https://www.ensembl.org/id/ENSMUSG00000115074" } ] } } ], "crossref": [ { "id": "ENSMUSG00000006471", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000006471", "database": "Bgee" }, { "id": "78797", "url": "https://www.ncbi.nlm.nih.gov/gene/78797", "database": "GeneID" }, { "id": "IPR001094", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001094", "database": "InterPro" }, { "id": "IPR001433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001433", "database": "InterPro" }, { "id": "IPR001709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001709", "database": "InterPro" }, { "id": "IPR003097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003097", "database": "InterPro" }, { "id": "IPR008254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008254", "database": "InterPro" }, { "id": "IPR017927", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017927", "database": "InterPro" }, { "id": "IPR017938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017938", "database": "InterPro" }, { "id": "IPR023173", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023173", "database": "InterPro" }, { "id": "IPR028879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028879", "database": "InterPro" }, { "id": "IPR029039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029039", "database": "InterPro" }, { "id": "IPR038878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038878", "database": "InterPro" }, { "id": "IPR039261", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039261", "database": "InterPro" }, { "id": "mmu:78797", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:78797", "database": "KEGG Pathway" }, { "id": "1926047", "url": "http://www.informatics.jax.org/marker/MGI:1926047", "database": "MGI" }, { "id": "CGALEHH", "url": "https://omabrowser.org/oma/group/CGALEHH/", "database": "OMA" }, { "id": "PISYQVG", "url": "https://omabrowser.org/oma/group/PISYQVG/", "database": "OMA" }, { "id": "QLFEMMP", "url": "https://omabrowser.org/oma/group/QLFEMMP/", "database": "OMA" }, { "id": "318396at2759", "url": "http://www.orthodb.org/?query=318396at2759", "database": "OrthoDB" }, { "id": "PTHR22791:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22791:SF21", "database": "PANTHER" }, { "id": "PF00175", "url": "http://pfam.xfam.org/family/PF00175", "database": "Pfam" }, { "id": "PF00258", "url": "http://pfam.xfam.org/family/PF00258", "database": "Pfam" }, { "id": "PF00667", "url": "http://pfam.xfam.org/family/PF00667", "database": "Pfam" }, { "id": "PR_A2AI05", "url": "http://purl.obolibrary.org/obo/PR_PR_A2AI05", "database": "PRO" }, { "id": "NP_001075945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075945", "database": "RefSeq" }, { "id": "NP_001239471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239471", "database": "RefSeq" }, { "id": "67716", "url": "https://www.rhea-db.org/rhea/67716", "database": "Rhea" }, { "id": "A0A2I3BPW1", "url": "https://www.uniprot.org/uniprot/A0A2I3BPW1", "database": "UniProtKB" }, { "id": "A0A2I3BPW1-1", "url": "https://www.uniprot.org/uniprot/A0A2I3BPW1-1", "database": "UniProtKB" }, { "id": "A0A2I3BQN1", "url": "https://www.uniprot.org/uniprot/A0A2I3BQN1", "database": "UniProtKB" }, { "id": "A0A2I3BQN1-1", "url": "https://www.uniprot.org/uniprot/A0A2I3BQN1-1", "database": "UniProtKB" }, { "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05", "database": "UniProtKB" }, { "id": "A2AI05-1", "url": "https://www.uniprot.org/uniprot/A2AI05-1", "database": "UniProtKB" }, { "id": "A2AI05-2", "url": "https://www.uniprot.org/uniprot/A2AI05-2", "database": "UniProtKB" }, { "id": "A2AI05-3", "url": "https://www.uniprot.org/uniprot/A2AI05-3", "database": "UniProtKB" }, { "id": "E0CX27", "url": "https://www.uniprot.org/uniprot/E0CX27", "database": "UniProtKB" }, { "id": "E0CX27-1", "url": "https://www.uniprot.org/uniprot/E0CX27-1", "database": "UniProtKB" }, { "id": "E0CXI9", "url": "https://www.uniprot.org/uniprot/E0CXI9", "database": "UniProtKB" }, { "id": "E0CXI9-1", "url": "https://www.uniprot.org/uniprot/E0CXI9-1", "database": "UniProtKB" }, { "id": "E0CYR1", "url": "https://www.uniprot.org/uniprot/E0CYR1", "database": "UniProtKB" }, { "id": "E0CYR1-1", "url": "https://www.uniprot.org/uniprot/E0CYR1-1", "database": "UniProtKB" }, { "id": "F6XCS1", "url": "https://www.uniprot.org/uniprot/F6XCS1", "database": "UniProtKB" }, { "id": "F6XCS1-1", "url": "https://www.uniprot.org/uniprot/F6XCS1-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MQVPQLLVLFGSQTGTAQDEAERLGREARRRRLGCRVQALDSYSVANLIREPLVIFVCATTGQGDPPDNMKNFWRFIFRKSLPSSSLCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPPCLGDDQHELGPDAAIDPWVGDLWEKIMVMYPVPLDIPEIPHGVPLPSKFIFQFLQEVPSIGAEELNIASSAPQTPPSELQPFLAPVITNQRVTGPQHFQDVRLIEFDITDSNISFAAGDVVFILPSNSEAHTQQFCQVLCLDPNQFFTLKPREPGVPDPPGLPQPCTVWNLVSQYLDIASVPRRSFFELLACLSQHALEREKLLELSSARGQEELWEYCSRPRRTILEVLCDFPHTAGAIPPDYLLDLIPRIRPRAFSIASSLLAHPRRLQILVAVVKYQTRLKEPRHGLCSSWLASLNPGQAGPVRVPLWVRPGSLVFPKTPDTPIIMVGAGTGVAPFRAAIQERVAHGQTGNFLFFGCRQRDQDFYWQTEWQKLEQKGWLTLVTAFSREQEQKVYVQHRLRELGPLVWELLDGQGAYFYLAGNAKYLPTDVSEALMSIFQEEGRLSTADASAYLARLQQTLRFQTETWA", "length": 598, "header": "sp|A2AI05-1|NDOR1_MOUSE Isoform 1 of NADPH-dependent diflavin oxidoreductase 1 OS=Mus musculus OX=10090 GN=Ndor1 PE=2 SV=1 CANONICAL=A2AI05-1" }, "isoforms": [ { "isoform_ac": "A0A2I3BPW1-1", "url": "https://www.uniprot.org/uniprot/A2AI05#A0A2I3BPW1-1", "sequence": { "sequence": "MTPRADLGRVCCPLCRQKTPMLEWEICQLQEELLRADGPQRPMRTASVTALHPGPWPWGPLEHRYQLRFLAGPVGGRSCLPFLPCPPSLGTWLWALRERGPCARRLSLLSLLVLELLGLVVIFMPLLLLGVLFMLLDRSTH", "length": 141, "header": "tr|A0A2I3BPW1-1|A0A2I3BPW1_MOUSE Computationally mapped isoform of NADPH-dependent diflavin oxidoreductase 1 OS=Mus musculus OX=10090 GN=Ndor1 PE=4 SV=2 CANONICAL=A2AI05-1" }, "locus": { "chromosome": "2", "start_pos": 25136212, "end_pos": 25135790, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000228627", "url": "https://www.ensembl.org/id/ENSMUST00000228627" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000153819", "url": "https://www.ensembl.org/id/ENSMUSP00000153819" } ] } }, { "isoform_ac": "A0A2I3BQN1-1", "url": "https://www.uniprot.org/uniprot/A2AI05#A0A2I3BQN1-1", "sequence": { "sequence": "MKNFWRFIFRKSLPSSSLCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPPCLGDDQHELGPDAAIDPWVGDLWEKIMVMYPVPLDIPEIPHGVPLPSKFIFQFLQEVPSIGAEELNIASSAPQTPPSELQPFLAPVITNQRVTGPQHFQDVRLIEFDITDSNISFAAGDVVFILPSNSEAHTQQFCQVLCLDPNQFFTLKPREPGVPDPPGLPQPCTVWNLVSQYLDIASVPRRSFFELLACLSQHALEREKLLELSSARGQEELWEYCSRPRRTILEVLCDFPHTAGAIPPDYLLDLIPRIRPRAFSIASSLLAHPRRLQILVAVVKYQTRLKEPRHGLCSSWLASLNPGQAGPVRVPLWVRPGSLVFPKTPDTPIIMVGAGTGVAPFRAAIQERVAHGQTGNFLFFGCRQRDQDFYWQTEWQKLEQKGWLTLVTAFSREQSSWSLRLRILTSVLVVTWDLMTPALCLLVHPVLLWVLSSWTHCASYQQMERMISGPLWVPELQTVNRNWRPETHPLPGPWSQLWKSRKKTPMLEWEICQLQEELLRADGPQRPMRTASVTALHPGPWPWGPLEHRYQLRFLAGPVGGRSCLPFLPCPPSLGTWLWALRERGPCARRLSLLSLLVLELLGLVVIFMPLLLLGVLFMLLDRSTH", "length": 662, "header": "tr|A0A2I3BQN1-1|NDOR1_MOUSE Computationally mapped isoform of NADPH-dependent diflavin oxidoreductase 1 OS=Mus musculus OX=10090 GN=Ndor1 PE=2 SV=1 CANONICAL=A2AI05-1" }, "locus": { "chromosome": "2", "start_pos": 25144881, "end_pos": 25135790, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000228052", "url": "https://www.ensembl.org/id/ENSMUST00000228052" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000154261", "url": "https://www.ensembl.org/id/ENSMUSP00000154261" } ] } }, { "isoform_ac": "A2AI05-1", "url": "https://www.uniprot.org/uniprot/A2AI05#A2AI05-1", "sequence": { "sequence": "MQVPQLLVLFGSQTGTAQDEAERLGREARRRRLGCRVQALDSYSVANLIREPLVIFVCATTGQGDPPDNMKNFWRFIFRKSLPSSSLCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPPCLGDDQHELGPDAAIDPWVGDLWEKIMVMYPVPLDIPEIPHGVPLPSKFIFQFLQEVPSIGAEELNIASSAPQTPPSELQPFLAPVITNQRVTGPQHFQDVRLIEFDITDSNISFAAGDVVFILPSNSEAHTQQFCQVLCLDPNQFFTLKPREPGVPDPPGLPQPCTVWNLVSQYLDIASVPRRSFFELLACLSQHALEREKLLELSSARGQEELWEYCSRPRRTILEVLCDFPHTAGAIPPDYLLDLIPRIRPRAFSIASSLLAHPRRLQILVAVVKYQTRLKEPRHGLCSSWLASLNPGQAGPVRVPLWVRPGSLVFPKTPDTPIIMVGAGTGVAPFRAAIQERVAHGQTGNFLFFGCRQRDQDFYWQTEWQKLEQKGWLTLVTAFSREQEQKVYVQHRLRELGPLVWELLDGQGAYFYLAGNAKYLPTDVSEALMSIFQEEGRLSTADASAYLARLQQTLRFQTETWA", "length": 598, "header": "sp|A2AI05-1|NDOR1_MOUSE Isoform 1 of NADPH-dependent diflavin oxidoreductase 1 OS=Mus musculus OX=10090 GN=Ndor1 PE=2 SV=1 CANONICAL=A2AI05-1" }, "locus": { "chromosome": "2", "start_pos": 25145363, "end_pos": 25137725, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000114349", "url": "https://www.ensembl.org/id/ENSMUST00000114349" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000109989", "url": "https://www.ensembl.org/id/ENSMUSP00000109989" } ] } }, { "isoform_ac": "A2AI05-2", "url": "https://www.uniprot.org/uniprot/A2AI05#A2AI05-2", "sequence": { "sequence": "MQVPQLLVLFGSQTGTAQDEAERLGREARRRRLGCRVQALDSYSVANLIREPLVIFVCATTGQGDPPDNMKNFWRFIFRKSLPSSSLCQMDFAVLGLGDSSYANLPSKFIFQFLQEVPSIGAEELNIASSAPQTPPSELQPFLAPVITNQRVTGPQHFQDVRLIEFDITDSNISFAAGDVVFILPSNSEAHTQQFCQVLCLDPNQFFTLKPREPGVPDPPGLPQPCTVWNLVSQYLDIASVPRRSFFELLACLSQHALEREKLLELSSARGQEELWEYCSRPRRTILEVLCDFPHTAGAIPPDYLLDLIPRIRPRAFSIASSLLAHPRRLQILVAVVKYQTRLKEPRHGLCSSWLASLNPGQAGPVRVPLWVRPGSLVFPKTPDTPIIMVGAGTGVAPFRAAIQERVAHGQTGNFLFFGCRQRDQDFYWQTEWQKLEQKGWLTLVTAFSREQEQKVYVQHRLRELGPLVWELLDGQGAYFYLAGNAKYLPTDVSEALMSIFQEEGRLSTADASAYLARLQQTLRFQTETWA", "length": 531, "header": "sp|A2AI05-2|NDOR1_MOUSE Isoform 2 of NADPH-dependent diflavin oxidoreductase 1 OS=Mus musculus OX=10090 GN=Ndor1 PE=2 SV=1 CANONICAL=A2AI05-1" }, "locus": { "chromosome": "2", "start_pos": 25145363, "end_pos": 25137725, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000100329", "url": "https://www.ensembl.org/id/ENSMUST00000100329" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000097903", "url": "https://www.ensembl.org/id/ENSMUSP00000097903" } ] } }, { "isoform_ac": "A2AI05-3", "url": "https://www.uniprot.org/uniprot/A2AI05#A2AI05-3", "sequence": { "sequence": "MRCREGTDQGCQRPYIYLCLVLEANLIREPLVIFVCATTGQGDPPDNMKNFWRFIFRKSLPSSSLCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPPCLGDDQHELGPDAAIDPWVGDLWEKIMVMYPVPLDIPEIPHGVPLPSKFIFQFLQEVPSIGAEELNIASSAPQTPPSELQPFLAPVITNQRVTGPQHFQDVRLIEFDITDSNISFAAGDVVFILPSNSEAHTQQFCQVLCLDPNQFFTLKPREPGVPDPPGLPQPCTVWNLVSQYLDIASVPRRSFFELLACLSQHALEREKLLELSSARGQEELWEYCSRPRRTILEVLCDFPHTAGAIPPDYLLDLIPRIRPRAFSIASSLLAHPRRLQILVAVVKYQTRLKEPRHGLCSSWLASLNPGQAGPVRVPLWVRPGSLVFPKTPDTPIIMVGAGTGVAPFRAAIQERVAHGQTGEYWSSKAV", "length": 466, "header": "sp|A2AI05-3|NDOR1_MOUSE Isoform 3 of NADPH-dependent diflavin oxidoreductase 1 OS=Mus musculus OX=10090 GN=Ndor1 PE=2 SV=1 CANONICAL=A2AI05-1" }, "locus": {} }, { "isoform_ac": "E0CX27-1", "url": "https://www.uniprot.org/uniprot/A2AI05#E0CX27-1", "sequence": { "sequence": "MQVPQLLVLFGSQTGTAQDEAERLGREARRRRLGCRVQALDSYSVVRLGRYGGDPPPDFAPSDGGRLSESH", "length": 71, "header": "tr|E0CX27-1|E0CX27_MOUSE Computationally mapped isoform of NADPH-dependent diflavin oxidoreductase 1 OS=Mus musculus OX=10090 GN=Ndor1 PE=1 SV=1 CANONICAL=A2AI05-1" }, "locus": { "chromosome": "2", "start_pos": 25145363, "end_pos": 25144943, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000132128", "url": "https://www.ensembl.org/id/ENSMUST00000132128" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000125018", "url": "https://www.ensembl.org/id/ENSMUSP00000125018" } ] } }, { "isoform_ac": "E0CXI9-1", "url": "https://www.uniprot.org/uniprot/A2AI05#E0CXI9-1", "sequence": { "sequence": "MQVPQLLVLFGSQTGTAQDEAERLGREARRRRLGCRVQALDSYSVVRLGRYGGDPPPDFAPSDGGRLSEGGGGMRCREGTDQGCQRPYIYLCLVLEANLIREPLVIFVCATTGQGDPPDNMKNFWRFIFRKSLPSSSLCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPPCLGDDQHELGPDAAIDPWVGDLWEKIMVMYPVPL", "length": 212, "header": "tr|E0CXI9-1|E0CXI9_MOUSE Computationally mapped isoform of NADPH-dependent diflavin oxidoreductase 1 OS=Mus musculus OX=10090 GN=Ndor1 PE=1 SV=1 CANONICAL=A2AI05-1" }, "locus": { "chromosome": "2", "start_pos": 25145363, "end_pos": 25140137, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000147866", "url": "https://www.ensembl.org/id/ENSMUST00000147866" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000125259", "url": "https://www.ensembl.org/id/ENSMUSP00000125259" } ] } }, { "isoform_ac": "E0CYR1-1", "url": "https://www.uniprot.org/uniprot/A2AI05#E0CYR1-1", "sequence": { "sequence": "MQVPQLLVLFGSQTGTAQDEAERLGREARRRRLGCRVQALDSYSVVKVVVGCGAGRALIKAARDLTSTCVLSSRRISLGSPW", "length": 82, "header": "tr|E0CYR1-1|E0CYR1_MOUSE Computationally mapped isoform of NADPH-dependent diflavin oxidoreductase 1 OS=Mus musculus OX=10090 GN=Ndor1 PE=1 SV=1 CANONICAL=A2AI05-1" }, "locus": { "chromosome": "2", "start_pos": 25145363, "end_pos": 25144929, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000148589", "url": "https://www.ensembl.org/id/ENSMUST00000148589" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000123958", "url": "https://www.ensembl.org/id/ENSMUSP00000123958" } ] } }, { "isoform_ac": "F6XCS1-1", "url": "https://www.uniprot.org/uniprot/A2AI05#F6XCS1-1", "sequence": { "sequence": "XVPQLLVLFGSQTGTAQDEAERLGREARRRRLGCRVQALDSYSVANLIREPLVIFVCATTGQGDPPDNMKNFWRFIFRKSLPSSSLCQMDFAVLGLGDSSYAKPDAAIDPWVGDLWEKIMVMYPVPLDIPEIPHGVPLPSKFIFQFLQEVPSIGAEELNIASSAPQTPPSELQPFLAPVITNQRVTGPQHFQDVRLIEFDITDSNISFAAGDVVFILPSNSEAHT", "length": 225, "header": "tr|F6XCS1-1|F6XCS1_MOUSE Computationally mapped isoform of NADPH-dependent diflavin oxidoreductase 1 OS=Mus musculus OX=10090 GN=Ndor1 PE=1 SV=1 CANONICAL=A2AI05-1" }, "locus": { "chromosome": "2", "start_pos": 25145358, "end_pos": 25139484, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000141808", "url": "https://www.ensembl.org/id/ENSMUST00000141808" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000123247", "url": "https://www.ensembl.org/id/ENSMUSP00000123247" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "mmu:78797", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:78797", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4ABT4-1", "protein_name": "NADPH-dependent diflavin oxidoreductase 1", "gene_name": "Ndor1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQVPQLLVLFGSQTGTAQDEAERLGREARRRRLGCRVQALDSYSVANLIREPLVIFVCATTGQGDPPDNMKNFWRFIFRKSLPSTSLCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGNALVPPCLGDDQHELGPDAAIDPWVGDLWEKIMTMYPVPLDIPEIPHGVPLPSKFIFQFLQEVPSIGAEELNLASSAPQTPPSELQPFLAPVVTNQRVTGPQHFQDVRLMEFDITESNISFAAGDVVLILPSNSEAHTKQFCQLLCLDPNQFFTLKPREPGVPYPPGLPQHCTVWHLVSQYLDIASVPRRSFFELLACLSPHALEREKLLEFSSARGQEELWEYCNRPRRTILEVLCDFPHTAGAIPPDYLLDLIPRIRPRAFSIASSLLAHPRRLQILVAVVKYQTRLKEPRRGLCSSWLASLTPGQAGPVRVPLWVRPGSLVFPKTPGTPIIMVGPGTGVAPFRAAIQERVAHGQMGNVLFFGCRQRDQDFYWQTEWQELEQRGCLTLVTAFSREQAQKVYVQHRLRELGPLVWELLDGQGAYFYLAGNAKYMPTDVSEALTAIFQEEGRLSTTDAAAYLARLQQTLRFQTETWA", "length": 598 }, "evidence": [ { "id": "7144", "url": "http://www.informatics.jax.org/homology/7144", "database": "MGI" }, { "id": "A2AI05", "url": "https://omabrowser.org/oma/group/A2AI05/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9UHB4-1", "protein_name": "NADPH-dependent diflavin oxidoreductase 1", "gene_name": "NDOR1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSSWLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNFLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA", "length": 597 }, "evidence": [ { "id": "7144", "url": "http://www.informatics.jax.org/homology/7144", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "integral component of membrane", "id": "GO:0016021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "" }, { "name": "intermediate filament cytoskeleton", "id": "GO:0045111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045111", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 12, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "" }, { "name": "FMN binding", "id": "GO:0010181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010181", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen", "id": "GO:0016709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016709", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "21873635" }, { "name": "electron transfer activity", "id": "GO:0009055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009055", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "" }, { "name": "flavin adenine dinucleotide binding", "id": "GO:0050660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050660", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "21873635" }, { "name": "FAD binding", "id": "GO:0071949", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071949", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "" }, { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "21873635" }, { "name": "NADPH dehydrogenase (quinone) activity", "id": "GO:0008753", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008753", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "" }, { "name": "NADPH binding", "id": "GO:0070402", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070402", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "" }, { "name": "NADP binding", "id": "GO:0050661", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050661", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "" }, { "name": "NADPH-hemoprotein reductase activity", "id": "GO:0003958", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003958", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "iron-sulfur cluster assembly", "id": "GO:0016226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016226", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "" }, { "name": "cellular response to menadione", "id": "GO:0036245", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036245", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "" }, { "name": "cell death", "id": "GO:0008219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008219", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "" }, { "name": "electron transport chain", "id": "GO:0022900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022900", "evidence": [ { "database": "UniProtKB", "id": "A2AI05", "url": "https://www.uniprot.org/uniprot/A2AI05" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 239, "end_pos": 241, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "67716", "name": "", "equation": "NADPH + 2 oxidized [2Fe-2S]-[protein] = H(+) + NADP(+) + 2 reduced [2Fe-2S]-[protein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9UHB4-1", "A2AI05-1" ], "evidence": [ { "id": "67716", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67716" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A2AI05", "gene_name": "Ndor1", "activity": [ { "ec_number": "1.18.1.-", "activity": "", "evidence": [ { "id": "A2AI05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AI05" } ] } ] }, { "uniprot_ac": "Q9UHB4", "gene_name": "NDOR1", "activity": [ { "ec_number": "1.18.1.-", "activity": "", "evidence": [ { "id": "Q9UHB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UHB4" } ] } ] } ], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ] }