{
    "uniprot_canonical_ac": "A2AD83-1",
    "uniprot_ac": "A2AD83",
    "uniprot_id": "FRMD7_MOUSE",
    "mass": {
        "chemical_mass": 80330.0,
        "monoisotopic_mass": 80330.0
    },
    "refseq": {
        "ac": "NP_001177261",
        "name": "FERM domain-containing protein 7",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177261"
    },
    "gene_names": [
        {
            "name": "Frmd7",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AD83",
            "id": "A2AD83"
        },
        {
            "name": "EG665849; Gm1533",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177261",
            "id": "NP_001177261"
        },
        {
            "name": "Frmd7",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177261",
            "id": "NP_001177261"
        }
    ],
    "protein_names": [
        {
            "name": "FERM domain-containing protein 7",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AD83#names_and_taxonomy",
            "id": "A2AD83"
        },
        {
            "name": "FERM domain-containing protein 7",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177261",
            "id": "NP_001177261"
        },
        {
            "name": "FERM domain-containing protein 7",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AD83#names_and_taxonomy",
            "id": "A2AD83"
        }
    ],
    "function": [
        {
            "annotation": "A novel splice variant of FRMD7 (FRMD7-S) with a shortened exon 4 relative to the original form of FRMD7 (FRMD7-FL) was identified from the cDNA of the human NT2 cell line and mouse fetal brain.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001177261",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177261"
                }
            ]
        },
        {
            "annotation": "FRMD7 as a key regulator in establishing a neuronal circuit asymmetry",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001177261",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177261"
                }
            ]
        },
        {
            "annotation": "FRMD7 expression is spatially and temporally regulated in human and mouse brain during embryonic and fetal development.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001177261",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177261"
                }
            ]
        },
        {
            "annotation": "Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AD83",
                    "url": "https://www.uniprot.org/uniprot/A2AD83#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0111790",
            "recommended_name": {
                "id": "DOID:0111790",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0111790",
                "name": "congenital nystagmus 1",
                "description": "A congenital nystagmus that has_material_basis_in mutation in FRMD7 on chromosome Xq26.2."
            },
            "synonyms": [
                {
                    "id": "DOID:0111790",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111790",
                    "name": "NYS1",
                    "description": ""
                },
                {
                    "id": "DOID:0111790",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111790",
                    "name": "X-linked infantile nystagmus 1",
                    "description": ""
                },
                {
                    "id": "DOID:0111790",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111790",
                    "name": "congenital motor nystagmus 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "nystagmus 1, congenital, X-linked",
                    "description": "Any congenital nystagmus in which the cause of the disease is a mutation in the FRMD7 gene."
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "nystagmus 1, congenital, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "Nystagmus, infantile idiopathic, formerly",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "NYS1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "NYSTAGMUS 1, congenital, X-linked; NYS1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "Nystagmus, infantile idiopathic",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "Nystagmus 1, infantile, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "Nystagmus 1, congenital, X- linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "Xlpan",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "congenital nystagmus caused by mutation in FRMD7",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "Nystagmus, congenital motor, 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "Nystagmus, infantile periodic alternating, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010693",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010693",
                    "name": "FRMD7 congenital nystagmus",
                    "description": ""
                },
                {
                    "id": "MIM:310700",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/310700",
                    "name": "Nystagmus congenital X-linked 1",
                    "description": "Nystagmus congenital X-linked 1"
                }
            ],
            "evidence": [
                {
                    "id": "0111790",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/gene/0111790#disease-associations"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AD83",
                    "url": "https://www.uniprot.org/uniprot/A2AD83"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Frmd7",
            "url": "https://www.uniprot.org/uniprot/A2AD83",
            "locus": {
                "chromosome": "X",
                "start_pos": 50942710,
                "end_pos": 50895180,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000036131",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000036131"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000036131",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000036131",
            "database": "Bgee"
        },
        {
            "id": "cd13193",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13193",
            "database": "CDD"
        },
        {
            "id": "cd14473",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14473",
            "database": "CDD"
        },
        {
            "id": "385354",
            "url": "https://www.ncbi.nlm.nih.gov/gene/385354",
            "database": "GeneID"
        },
        {
            "id": "IPR000299",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000299",
            "database": "InterPro"
        },
        {
            "id": "IPR011993",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993",
            "database": "InterPro"
        },
        {
            "id": "IPR014352",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR014352",
            "database": "InterPro"
        },
        {
            "id": "IPR014847",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR014847",
            "database": "InterPro"
        },
        {
            "id": "IPR018979",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018979",
            "database": "InterPro"
        },
        {
            "id": "IPR018980",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018980",
            "database": "InterPro"
        },
        {
            "id": "IPR019747",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019747",
            "database": "InterPro"
        },
        {
            "id": "IPR019748",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019748",
            "database": "InterPro"
        },
        {
            "id": "IPR019749",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019749",
            "database": "InterPro"
        },
        {
            "id": "IPR029071",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071",
            "database": "InterPro"
        },
        {
            "id": "IPR035963",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035963",
            "database": "InterPro"
        },
        {
            "id": "IPR041788",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041788",
            "database": "InterPro"
        },
        {
            "id": "mmu:385354",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:385354",
            "database": "KEGG Pathway"
        },
        {
            "id": "2686379",
            "url": "http://www.informatics.jax.org/marker/MGI:2686379",
            "database": "MGI"
        },
        {
            "id": "ERPDSCL",
            "url": "https://omabrowser.org/oma/group/ERPDSCL/",
            "database": "OMA"
        },
        {
            "id": "476668at2759",
            "url": "http://www.orthodb.org/?query=476668at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PF00373",
            "url": "http://pfam.xfam.org/family/PF00373",
            "database": "Pfam"
        },
        {
            "id": "PF08736",
            "url": "http://pfam.xfam.org/family/PF08736",
            "database": "Pfam"
        },
        {
            "id": "PF09379",
            "url": "http://pfam.xfam.org/family/PF09379",
            "database": "Pfam"
        },
        {
            "id": "PF09380",
            "url": "http://pfam.xfam.org/family/PF09380",
            "database": "Pfam"
        },
        {
            "id": "PR_A2AD83",
            "url": "http://purl.obolibrary.org/obo/PR_PR_A2AD83",
            "database": "PRO"
        },
        {
            "id": "NP_001177261",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177261",
            "database": "RefSeq"
        },
        {
            "id": "A2AD83",
            "url": "https://www.uniprot.org/uniprot/A2AD83",
            "database": "UniProtKB"
        },
        {
            "id": "A2AD83-1",
            "url": "https://www.uniprot.org/uniprot/A2AD83-1",
            "database": "UniProtKB"
        },
        {
            "id": "E9PXK8",
            "url": "https://www.uniprot.org/uniprot/E9PXK8",
            "database": "UniProtKB"
        },
        {
            "id": "E9PXK8-1",
            "url": "https://www.uniprot.org/uniprot/E9PXK8-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCGHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVKNPKEVVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHEETVRKHLVQTQYLPSQASLESKIMQFHQQHIGRSPAESDILLLDIARKLDMYGIRPQPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYGKKGRLKSLPFERKQYPSQYHERQCRSSPDILSDVSKQVEDLRLTYGSSYYRNVNGVHASESMLDSRRRNSAVEVTFAAELEHSKPEAEATSLHPSQSSSSFTFIYADPVFNTDPEPIEFFEERSPLSSFQTTSKFADSHTSKASPARQLTYTDVPYIPCTSQKVDIMPPQVFFYVDKPPQVPRRSLIMAEENMRPDSYVDHSAIKPAKRSPRNMRIKSLQQDLQELQEAMARTSGRSNINVEPEEEDPHLDDAFAYNLQEQTPKRSQSQSDMKTIRFPFGSEFRPLGPCPALTRKTDLFACTFAEQEFPTVLIDQSSAERYVASESSDSESEIIKPDYYFLYGKGTKSPRARIRLSSGSLQLEEEDETISFATPGAEDRTLLKPCNYFLA",
        "length": 703,
        "header": "sp|A2AD83-1|FRMD7_MOUSE Isoform 1 of FERM domain-containing protein 7  OS=Mus musculus OX=10090 GN=Frmd7 PE=1 SV=1 CANONICAL=A2AD83-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2AD83-1",
            "url": "https://www.uniprot.org/uniprot/A2AD83#A2AD83-1",
            "sequence": {
                "sequence": "MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCGHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVKNPKEVVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHEETVRKHLVQTQYLPSQASLESKIMQFHQQHIGRSPAESDILLLDIARKLDMYGIRPQPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYGKKGRLKSLPFERKQYPSQYHERQCRSSPDILSDVSKQVEDLRLTYGSSYYRNVNGVHASESMLDSRRRNSAVEVTFAAELEHSKPEAEATSLHPSQSSSSFTFIYADPVFNTDPEPIEFFEERSPLSSFQTTSKFADSHTSKASPARQLTYTDVPYIPCTSQKVDIMPPQVFFYVDKPPQVPRRSLIMAEENMRPDSYVDHSAIKPAKRSPRNMRIKSLQQDLQELQEAMARTSGRSNINVEPEEEDPHLDDAFAYNLQEQTPKRSQSQSDMKTIRFPFGSEFRPLGPCPALTRKTDLFACTFAEQEFPTVLIDQSSAERYVASESSDSESEIIKPDYYFLYGKGTKSPRARIRLSSGSLQLEEEDETISFATPGAEDRTLLKPCNYFLA",
                "length": 703,
                "header": "sp|A2AD83-1|FRMD7_MOUSE Isoform 1 of FERM domain-containing protein 7  OS=Mus musculus OX=10090 GN=Frmd7 PE=1 SV=1 CANONICAL=A2AD83-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 50031587,
                "end_pos": 49984060,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000060650",
                        "url": "https://www.ensembl.org/id/ENSMUST00000060650"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000057103",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000057103"
                    }
                ]
            }
        },
        {
            "isoform_ac": "E9PXK8-1",
            "url": "https://www.uniprot.org/uniprot/A2AD83#E9PXK8-1",
            "sequence": {
                "sequence": "MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCGHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVKSKYGRSLKGWGIFLLFK",
                "length": 85,
                "header": "tr|E9PXK8-1|E9PXK8_MOUSE Computationally mapped isoform of FERM domain-containing protein 7  OS=Mus musculus OX=10090 GN=Frmd7 PE=4 SV=1 CANONICAL=A2AD83-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 50031587,
                "end_pos": 49998706,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000164311",
                        "url": "https://www.ensembl.org/id/ENSMUST00000164311"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000126628",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000126628"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "The nystagmus-associated FRMD7 gene regulates neuronal outgrowth and development.",
            "journal": "Hum. Mol. Genet.",
            "date": "2010",
            "authors": "Crosier M., Lindsay S., Salomoni P., Bartesaghi S., Betts-Henderson J., Chen H.L., Gottlob I., Nicotera P.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AD83",
                    "url": "https://www.uniprot.org/uniprot/A2AD83"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001177261",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177261"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19892780",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/19892780"
                }
            ]
        },
        {
            "title": "Identification of a novel FRMD7 splice variant and functional analysis of two FRMD7 transcripts during human NT2 cell differentiation.",
            "journal": "Molecular vision",
            "date": "2011",
            "authors": "Li Y, Pu J, Liu Z, Xu S, Jin F, Zhu L, Tian J, Luo J, Zhang B",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001177261",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177261"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22128244",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22128244"
                }
            ]
        },
        {
            "title": "Congenital Nystagmus Gene FRMD7 Is Necessary for Establishing a Neuronal Circuit Asymmetry for Direction Selectivity.",
            "journal": "Neuron",
            "date": "2016",
            "authors": "Yonehara K, Fiscella M, Drinnenberg A, Esposti F, Trenholm S, Krol J, Franke F, Scherf BG, Kusnyerik A, Muller J, Szabo A, Juttner J, Cordoba F, Reddy AP, Nemeth J, Nagy ZZ, Munier F, Hierlemann A, Roska B",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001177261",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177261"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26711119",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/26711119"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:385354",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:385354",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "F1M1Y3-1",
            "protein_name": "FERM domain-containing 7",
            "gene_name": "Frmd7",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGHNVWLELLKPITKQVKNPKEVVFKFIVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHEEMVRKHLVQTQYLPSQACLESKIMQFHQQHIGRSPAESDILLLDIARKLDMYGIRPQPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYGKKGRLKSLPFERKQYPSQYHERQCRSSPDILSDVSKQVEDLRLTYGSSYYRNVNGVHASEPMLDGRRRNSAVEVTFAAELEHSKPEAEAASLHPSQSSSSFTFIYADPVFNTDPEPIDFFEERSPLSSFQTNSKFVDGHTSKVSPARQLTYTDVPYIPCTSQKVDIMPPQVFFYVDKPPQVPRRSLMMAEESMRPDSYVDPSAIKPAKRSPRNMRIKSLQQDLQELQEAMARTSGRSNINVEPEEEDPHLDDAFAYNLQEQTPKRSQSQSDMKTIRFPFGSEFRPLGPCPALTRKTDLFTCTFAEQEFPTVLMDQSSAERYVASESSDSESEILKTDYYSLYGKGTKSPRARIRLSSGSLQLEEEDEAISFGTPGAEDRTLLKPCNYFLA",
                "length": 703
            },
            "evidence": [
                {
                    "id": "18855",
                    "url": "http://www.informatics.jax.org/homology/18855",
                    "database": "MGI"
                },
                {
                    "id": "A2AD83",
                    "url": "https://omabrowser.org/oma/group/A2AD83/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q6ZUT3-1",
            "protein_name": "FERM domain-containing protein 7",
            "gene_name": "FRMD7",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHEETDRKHLAQTRYLPNQDCLEGKIMHFHQKHIGRSPAESDILLLDIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQSQSSSSFPFIYMDPVFNTEPNPNPDPRDIFSERSSLSSFQTSCKFSGNHMSIYSGLTSKVRPAKQLTYTDVPYIPCTGQQVGIMPPQVFFYVDKPPQVPRWSPIRAEERTSPHSYVEPTAMKPAERSPRNIRMKSFQQDLQVLQEAIARTSGRSNINVGLEEEDPNLEDAFVCNIQEQTPKRSQSQSDMKTIRFPFGSEFRPLGPCPALSHKADLFTDMFAEQELPAVLMDQSTAERYVASESSDSESEILKPDYYALYGKEIRSPMARIRLSSGSLQLDEEDEDAYFNTPTAEDRTSLKPCNYFLA",
                "length": 714
            },
            "evidence": [
                {
                    "id": "18855",
                    "url": "http://www.informatics.jax.org/homology/18855",
                    "database": "MGI"
                },
                {
                    "id": "A2AD83",
                    "url": "https://omabrowser.org/oma/group/A2AD83/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 6,
                "go_terms": [
                    {
                        "name": "positive regulation of small GTPase mediated signal transduction",
                        "id": "GO:0051057",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051057",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AD83",
                                "url": "https://www.uniprot.org/uniprot/A2AD83"
                            }
                        ],
                        "pmid": "23967341"
                    },
                    {
                        "name": "nervous system development",
                        "id": "GO:0007399",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AD83",
                                "url": "https://www.uniprot.org/uniprot/A2AD83"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of protein binding",
                        "id": "GO:0032091",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032091",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AD83",
                                "url": "https://www.uniprot.org/uniprot/A2AD83"
                            }
                        ],
                        "pmid": "23967341"
                    },
                    {
                        "name": "regulation of neuron projection development",
                        "id": "GO:0010975",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010975",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AD83",
                                "url": "https://www.uniprot.org/uniprot/A2AD83"
                            }
                        ],
                        "pmid": "19892780"
                    },
                    {
                        "name": "positive regulation of lamellipodium assembly",
                        "id": "GO:0010592",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010592",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AD83",
                                "url": "https://www.uniprot.org/uniprot/A2AD83"
                            }
                        ],
                        "pmid": "23967341"
                    },
                    {
                        "name": "negative regulation of stress fiber assembly",
                        "id": "GO:0051497",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051497",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AD83",
                                "url": "https://www.uniprot.org/uniprot/A2AD83"
                            }
                        ],
                        "pmid": "23967341"
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 7,
                "go_terms": [
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AD83",
                                "url": "https://www.uniprot.org/uniprot/A2AD83"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AD83",
                                "url": "https://www.uniprot.org/uniprot/A2AD83"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoskeleton",
                        "id": "GO:0005856",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AD83",
                                "url": "https://www.uniprot.org/uniprot/A2AD83"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AD83",
                                "url": "https://www.uniprot.org/uniprot/A2AD83"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "growth cone",
                        "id": "GO:0030426",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AD83",
                                "url": "https://www.uniprot.org/uniprot/A2AD83"
                            }
                        ],
                        "pmid": "19892780"
                    },
                    {
                        "name": "neuronal cell body",
                        "id": "GO:0043025",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AD83",
                                "url": "https://www.uniprot.org/uniprot/A2AD83"
                            }
                        ],
                        "pmid": "19892780"
                    },
                    {
                        "name": "neuron projection",
                        "id": "GO:0043005",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AD83",
                                "url": "https://www.uniprot.org/uniprot/A2AD83"
                            }
                        ],
                        "pmid": "19892780"
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "guanyl-nucleotide exchange factor activity",
                        "id": "GO:0005085",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AD83",
                                "url": "https://www.uniprot.org/uniprot/A2AD83"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 116,
            "end_pos": 118,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 29,
            "end_pos": 31,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ]
}