{ "bcoid": "GLY_000280", "title": "Rat Glycohydrolases", "description": "The Rat Glycohydrolases dataset contains a list of rat [taxid:9606] glycohydrolases derived from UniProtKB ...", "filename": "rat_protein_glycohydrolase.csv", "filetype": "csv", "categories": { "species": "Rattus norvegicus", "molecule": "Protein", "tags": "Glycohydrolases", "file_type": "csv", "status": "Reviewed", "scope": "internal" }, "minitable": { "content": [ [ "P06760-1...", "Rattus norve..." ], [ "P00689-1...", "Rattus norve..." ] ], "headers": [ "uniprotkb_ca...", "species..." ], "colwidth": [ "40%", "20%" ] }, "sampledata": { "type": "table", "data": [ [ { "type": "string", "label": "uniprotkb_canonical_ac" }, { "type": "string", "label": "species" }, { "type": "string", "label": "status" }, { "type": "string", "label": "gene_symbol" }, { "type": "string", "label": "uniprotkb_protein_name" }, { "type": "string", "label": "ec_number" }, { "type": "string", "label": "brenda_ec_number" }, { "type": "string", "label": "cazy_gh_gamily" }, { "type": "string", "label": "interpro_id" }, { "type": "string", "label": "pfam_ac" }, { "type": "string", "label": "go_molecular_function" } ], [ "P06760-1", "Rattus norvegicus (Rat)", "reviewed", "Gusb", "Beta-glucuronidase (EC 3.2.1.31)", "3.2.1.31", "", "GH2", "IPR036156|IPR008979|IPR006101|IPR023232|IPR006103|IPR023230|IPR006102|IPR006104|IPR017853|IPR013783", "PF00703|PF02836|PF02837", "beta-glucuronidase activity [GO:0004566]|carbohydrate binding [GO:0030246]|signaling receptor binding [GO:0005102]" ], [ "P00689-1", "Rattus norvegicus (Rat)", "reviewed", "Amy2", "Pancreatic alpha-amylase (PA) (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase)", "3.2.1.1", "", "GH13", "IPR006048|IPR031319|IPR006046|IPR006047|IPR013780|IPR017853", "PF00128|PF02806", "alpha-amylase activity [GO:0004556]|alpha-amylase activity (releasing maltohexaose) [GO:0103025]|calcium ion binding [GO:0005509]|chloride ion binding [GO:0031404]" ], [ "Q6RY07-1", "Rattus norvegicus (Rat)", "reviewed", "Chia", "Acidic mammalian chitinase (AMCase) (EC 3.2.1.14)", "3.2.1.14", "", "GH18", "IPR002557|IPR036508|IPR011583|IPR029070|IPR001223|IPR001579|IPR017853", "PF01607|PF00704", "chitinase activity [GO:0004568]|chitin binding [GO:0008061]" ], [ "Q6AYS4-1", "Rattus norvegicus (Rat)", "reviewed", "Fuca2", "Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2)", "3.2.1.51", "3.2.1.51", "GH29", "IPR016286|IPR031919|IPR000933|IPR018526|IPR013780|IPR017853", "PF01120|PF16757", "alpha-L-fucosidase activity [GO:0004560]" ], [ "P17164-1", "Rattus norvegicus (Rat)", "reviewed", "Fuca1", "Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1)", "3.2.1.51", "3.2.1.51", "GH29", "IPR016286|IPR028755|IPR031919|IPR000933|IPR018526|IPR013780|IPR017853", "PF01120|PF16757", "alpha-L-fucosidase activity [GO:0004560]|carbohydrate binding [GO:0030246]|fucosidase activity [GO:0015928]" ], [ "Q02401-1", "Rattus norvegicus (Rat)", "reviewed", "Lct", "Lactase-phlorizin hydrolase (Lactase-glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Phlorizin hydrolase (EC 3.2.1.62)]", "3.2.1.108|3.2.1.62", "", "GH1", "IPR001360|IPR018120|IPR033132|IPR017853", "PF00232", "beta-glucosidase activity [GO:0008422]|glycosylceramidase activity [GO:0017042]|lactase activity [GO:0000016]|transferase activity [GO:0016740]" ], [ "Q05820-1", "Rattus norvegicus (Rat)", "reviewed", "Lyz2", "Putative lysozyme C-2 (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C)", "3.2.1.17", "", "GH22", "IPR001916|IPR019799|IPR000974|IPR023346|IPR030056", "PF00062", "lysozyme activity [GO:0003796]" ], [ "Q8VIJ5-1", "Rattus norvegicus (Rat)", "reviewed", "Oga", "Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Bifunctional protein NCOAT) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase)", "3.2.1.169", "", "GH84", "IPR016181|IPR011496|IPR017853", "PF07555", "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity [GO:0102571]|[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity [GO:0102167]|[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity [GO:0102166]|beta-N-acetylglucosaminidase activity [GO:0016231]|histone acetyltransferase activity [GO:0004402]" ], [ "Q71RP1-1", "Rattus norvegicus (Rat)", "reviewed", "Hpse", "Heparanase (EC 3.2.1.166) (Endo-glucoronidase) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit]", "3.2.1.166", "", "GH79", "IPR005199|IPR017853", "PF03662", "heparanase activity [GO:0030305]" ], [ "Q9Z2Y9-1", "Rattus norvegicus (Rat)", "reviewed", "Kl", "Klotho (EC 3.2.1.31) [Cleaved into: Klotho peptide]", "3.2.1.31", "", "GH1", "IPR001360|IPR033132|IPR017853|IPR028546", "PF00232", "beta-glucosidase activity [GO:0008422]|beta-glucuronidase activity [GO:0004566]|fibroblast growth factor binding [GO:0017134]|fibroblast growth factor receptor binding [GO:0005104]" ], [ "Q9Z2Q3-1", "Rattus norvegicus (Rat)", "reviewed", "Hyal2", "Hyaluronidase-2 (Hyal-2) (EC 3.2.1.35) (Hyaluronoglucosaminidase-2)", "3.2.1.35", "3.2.1.35", "GH56", "IPR013785|IPR017853|IPR018155", "PF01630", "hyaluronic acid binding [GO:0005540]|hyaluronoglucuronidase activity [GO:0033906]|hyalurononglucosaminidase activity [GO:0004415]|receptor signaling protein tyrosine kinase inhibitor activity [GO:0030294]|virus receptor activity [GO:0001618]" ], [ "Q76HM9-1", "Rattus norvegicus (Rat)", "reviewed", "Hyal3", "Hyaluronidase-3 (Hyal-3) (EC 3.2.1.35) (Hyaluronoglucosaminidase-3)", "3.2.1.35", "3.2.1.35", "GH56", "IPR013785|IPR013032|IPR017853|IPR018155|IPR027260", "PF01630", "hyalurononglucosaminidase activity [GO:0004415]" ], [ "Q76HN1-1", "Rattus norvegicus (Rat)", "reviewed", "Hyal1", "Hyaluronidase-1 (Hyal-1) (EC 3.2.1.35) (Hyaluronoglucosaminidase-1)", "3.2.1.35", "3.2.1.35", "GH56", "IPR013785|IPR017853|IPR018155", "PF01630", "hyaluronan synthase activity [GO:0050501]|hyalurononglucosaminidase activity [GO:0004415]|transcription factor binding [GO:0008134]" ], [ "Q62803-1", "Rattus norvegicus (Rat)", "reviewed", "Spam1", "Hyaluronidase PH-20 (Hyal-PH20) (EC 3.2.1.35) (Hyaluronoglucosaminidase PH-20) (Sperm adhesion molecule 1) (Sperm surface antigen 2B1) (Sperm surface protein PH-20)", "3.2.1.35", "", "GH56", "IPR013785|IPR017853|IPR018155|IPR001439", "PF01630", "hyalurononglucosaminidase activity [GO:0004415]" ], [ "B2GUY0-1", "Rattus norvegicus (Rat)", "reviewed", "Man1b1", "Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (ER mannosidase 1) (ERMan1) (Mannosidase alpha class 1B member 1)", "3.2.1.113", "", "GH47", "IPR012341|IPR001382|IPR036026", "PF01532", "calcium ion binding [GO:0005509]|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" ], [ "P00697-1", "Rattus norvegicus (Rat)", "reviewed", "Lyz1", "Lysozyme C-1 (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C)", "3.2.1.17", "", "GH22", "IPR001916|IPR019799|IPR000974|IPR023346|IPR030056", "PF00062", "hydrolase activity, acting on glycosyl bonds [GO:0016798]|lysozyme activity [GO:0003796]" ], [ "Q64627-1", "Rattus norvegicus (Rat)", "reviewed", "Neu2", "Sialidase-2 (EC 3.2.1.18) (Cytosolic sialidase) (N-acetyl-alpha-neuraminidase 2)", "3.2.1.18", "", "GH33", "IPR011040|IPR026945|IPR026856|IPR036278", "PF13088", "exo-alpha-(2->3)-sialidase activity [GO:0052794]|exo-alpha-(2->6)-sialidase activity [GO:0052795]|exo-alpha-(2->8)-sialidase activity [GO:0052796]|exo-alpha-sialidase activity [GO:0004308]" ], [ "Q99PW3-1", "Rattus norvegicus (Rat)", "reviewed", "Neu1", "Sialidase-1 (EC 3.2.1.18) (Lysosomal sialidase) (N-acetyl-alpha-neuraminidase 1)", "3.2.1.18", "", "GH33", "IPR011040|IPR026856|IPR036278", "PF13088", "exo-alpha-(2->3)-sialidase activity [GO:0052794]|exo-alpha-(2->6)-sialidase activity [GO:0052795]|exo-alpha-(2->8)-sialidase activity [GO:0052796]|exo-alpha-sialidase activity [GO:0004308]" ], [ "Q99PW5-1", "Rattus norvegicus (Rat)", "reviewed", "Neu3", "Sialidase-3 (EC 3.2.1.18) (Ganglioside sialidase) (Membrane sialidase) (N-acetyl-alpha-neuraminidase 3)", "3.2.1.18", "", "GH33", "IPR011040|IPR026944|IPR026856|IPR036278", "PF13088", "exo-alpha-(2->3)-sialidase activity [GO:0052794]|exo-alpha-(2->6)-sialidase activity [GO:0052795]|exo-alpha-(2->8)-sialidase activity [GO:0052796]|exo-alpha-sialidase activity [GO:0004308]" ], [ "P23739-1", "Rattus norvegicus (Rat)", "reviewed", "Si", "Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]", "3.2.1.48|3.2.1.10", "3.2.1.10", "GH31", "IPR031727|IPR011013|IPR000322|IPR030458|IPR030459|IPR013780|IPR017853|IPR017957|IPR000519", "PF01055|PF16863|PF00088", "beta-fructofuranosidase activity [GO:0004564]|carbohydrate binding [GO:0030246]|oligo-1,6-glucosidase activity [GO:0004574]|sucrose alpha-glucosidase activity [GO:0004575]" ], [ "O88941-1", "Rattus norvegicus (Rat)", "reviewed", "Mogs", "Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Glycoprotein-processing glucosidase I)", "3.2.1.106", "", "GH63", "IPR008928|IPR012341|IPR031335|IPR031631|IPR038518|IPR004888", "PF03200|PF16923", "mannosyl-oligosaccharide glucosidase activity [GO:0004573]" ], [ "Q641X3-1", "Rattus norvegicus (Rat)", "reviewed", "Hexa", "Beta-hexosaminidase subunit alpha (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit alpha) (Hexosaminidase subunit A) (N-acetyl-beta-glucosaminidase subunit alpha)", "3.2.1.52", "", "GH20", "IPR025705|IPR015883|IPR017853|IPR029018|IPR029019", "PF00728|PF14845", "beta-N-acetylhexosaminidase activity [GO:0004563]|N-acetyl-beta-D-galactosaminidase activity [GO:0102148]" ], [ "Q6AXR4-1", "Rattus norvegicus (Rat)", "reviewed", "Hexb", "Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (N-acetyl-beta-glucosaminidase subunit beta)", "3.2.1.52", "", "GH20", "IPR025705|IPR015883|IPR017853|IPR029018|IPR029019", "PF00728|PF14845", "beta-N-acetylglucosaminidase activity [GO:0016231]|carbohydrate binding [GO:0030246]|hexosaminidase activity [GO:0015929]|N-acetyl-beta-D-galactosaminidase activity [GO:0102148]|protein heterodimerization activity [GO:0046982]|protein homodimerization activity [GO:0042803]" ], [ "Q5XIL5-1", "Rattus norvegicus (Rat)", "reviewed", "Glb1l3", "Beta-galactosidase-1-like protein 3 (EC 3.2.1.-)", "3.2.1.-", "", "GH35", "IPR026283|IPR008979|IPR031330|IPR019801|IPR001944|IPR017853", "PF01301", "beta-galactosidase activity [GO:0004565]" ], [ "Q5GF25-1", "Rattus norvegicus (Rat)", "reviewed", "Manea", "Glycoprotein endo-alpha-1,2-mannosidase (Endo-alpha mannosidase) (Endomannosidase) (rEndo) (EC 3.2.1.130) (Endo-alpha-D-mannosidase) (Enman)", "3.2.1.130", "3.2.1.130", "GH99", "IPR026071", "PF16317", "alpha-mannosidase activity [GO:0004559]|glycoprotein endo-alpha-1,2-mannosidase activity [GO:0004569]" ], [ "Q6P7A9-1", "Rattus norvegicus (Rat)", "reviewed", "Gaa", "Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase)", "3.2.1.20", "", "GH31", "IPR031727|IPR011013|IPR000322|IPR030458|IPR030459|IPR025887|IPR013780|IPR017853|IPR017957|IPR000519", "PF13802|PF01055|PF16863|PF00088", "alpha-1,4-glucosidase activity [GO:0004558]|carbohydrate binding [GO:0030246]|maltose alpha-glucosidase activity [GO:0032450]" ], [ "P28494-1", "Rattus norvegicus (Rat)", "reviewed", "Man2a1", "Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)", "3.2.1.114", "", "GH38", "IPR011013|IPR011330|IPR011682|IPR015341|IPR037094|IPR000602|IPR027291|IPR028995|IPR013780", "PF09261|PF07748|PF01074", "alpha-mannosidase activity [GO:0004559]|carbohydrate binding [GO:0030246]|hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799]|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity [GO:0004572]|metal ion binding [GO:0046872]" ], [ "Q5M868-1", "Rattus norvegicus (Rat)", "reviewed", "Gba2", "Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) (Beta-glucocerebrosidase 2) (Beta-glucosidase 2) (Bile acid beta-glucosidase GBA2) (Bile acid glucosyl transferase GBA2) (Cholesterol glucosyltransferase GBA2) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase GBA2) (EC 3.2.1.104) (Glucosylceramidase 2)", "3.2.1.45|2.4.1.-|3.2.1.104", "", "GH116", "IPR008928|IPR012341|IPR014551|IPR006775|IPR024462", "PF04685|PF12215", "beta-glucosidase activity [GO:0008422]|glucosylceramidase activity [GO:0004348]|glucosyltransferase activity [GO:0046527]|steryl-beta-glucosidase activity [GO:0050295]" ], [ "P21139-1", "Rattus norvegicus (Rat)", "reviewed", "Man2c1", "Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1)", "3.2.1.24", "", "GH38", "IPR011013|IPR041147|IPR011330|IPR011682|IPR015341|IPR037094|IPR000602|IPR027291|IPR028995", "PF09261|PF17677|PF07748|PF01074", "alpha-mannosidase activity [GO:0004559]|carbohydrate binding [GO:0030246]|metal ion binding [GO:0046872]" ], [ "Q4FZV0-1", "Rattus norvegicus (Rat)", "reviewed", "Manba", "Beta-mannosidase (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase)", "3.2.1.25", "", "GH2", "IPR036156|IPR041625|IPR008979|IPR006103|IPR017853|IPR013783|IPR041447", "PF02836|PF17753|PF17786", "beta-mannosidase activity [GO:0004567]|mannose binding [GO:0005537]" ], [ "Q01460-1", "Rattus norvegicus (Rat)", "reviewed", "Ctbs", "Di-N-acetylchitobiase (EC 3.2.1.-)", "3.2.1.-", "", "GH18", "IPR011583|IPR029070|IPR001223|IPR001579|IPR017853", "PF00704", "chitinase activity [GO:0004568]|chitin binding [GO:0008061]|hydrolase activity, acting on glycosyl bonds [GO:0016798]" ], [ "Q66H12-1", "Rattus norvegicus (Rat)", "reviewed", "Naga", "Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B)", "3.2.1.49", "", "GH27", "IPR013785|IPR002241|IPR000111|IPR013780|IPR017853|IPR035373", "PF16499|PF17450", "alpha-galactosidase activity [GO:0004557]|alpha-N-acetylgalactosaminidase activity [GO:0008456]|protein homodimerization activity [GO:0042803]" ], [ "Q794F9-1", "Rattus norvegicus (Rat)", "reviewed", "Slc3a2", "4F2 cell-surface antigen heavy chain (4F2hc) (Solute carrier family 3 member 2) (CD antigen CD98)", "", "", "GH13", "IPR006047|IPR013780|IPR017853|IPR042280|IPR031984", "PF00128|PF16028", "catalytic activity [GO:0003824]|neutral amino acid transmembrane transporter activity [GO:0015175]" ], [ "Q9WTV1-1", "Rattus norvegicus (Rat)", "reviewed", "Chi3l1", "Chitinase-3-like protein 1 (Cartilage glycoprotein 39) (CGP-39) (GP-39)", "", "", "GH18", "IPR028538|IPR011583|IPR029070|IPR001223|IPR017853", "PF00704", "carbohydrate binding [GO:0030246]|chitin binding [GO:0008061]" ], [ "Q64319-1", "Rattus norvegicus (Rat)", "reviewed", "Slc3a1", "Neutral and basic amino acid transport protein rBAT (D2) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein) (NAA-TR)", "", "", "GH13", "IPR006047|IPR013780|IPR017853", "PF00128", "catalytic activity [GO:0003824]|protein heterodimerization activity [GO:0046982]" ] ] }, "readme": "Name\n - Rat Glycohydrolases\n\nVersion\n - 1.11.2\n\nCreated on\n - 2019-09-11T17:20:18.184619\n\nModified on\n - 2020-04-10T12:12:13.136231\n\nCreated by\n - Jeet Vora [jeetvora@gwu.edu], Rahi Navelkar [rsn13@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Xavier Holmes [xavierh@email.gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Amanda Bell [amandab2140@gwu.edu], Jonathon Keeney [keeneyjg@gwu.edu], Millicent Quartey [mquartey@email.gwu.edu]\n\nAuthors\n - \n\nChecksum\n - \n\nUsability Domain\n - The Rat Glycohydrolases dataset contains a list of rat [taxid:9606] glycohydrolases derived from UniProtKB database using advanced search and other databases including CAZy, InterPro and Pfam. . If you use this dataset please provide proper attribution to EMBL-EBI-UniProtKB and GlyGen\n\nDescription Domain\n Keywords\n - glycohydrolase\n - glycosidase\n - EC Number\n - CAZy\n\n Pipeline Steps\n - Step-1: The script maps and replaces the UniProtKB accession to the UniProtKB canonical accession\n\nExecution Domain\n Scripts - https://github.com/GW-HIVE/glygen-backend-integration/blob/master/pipeline/integrator/make-protein-dataset.py\n\n\n Software Prerequisites\n Name: Python\n Version: 2.7.5\n URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n Input Subdomain\n Name: rat_protein_glycosyltransferase.csv\n URI: https://data.glygen.org/ln2wwwdata/compiled/rat_protein_glycosyltransferase.csv\n Name: rat_protein_masterlist.csv\n URI: https://data.glygen.org/ln2wwwdata/reviewed/rat_protein_masterlist.csv\n Output Subdomain\n Name: rat_protein_glycohydrolase.csv\n URI: https://data.glygen.org/ln2wwwdata/reviewed/rat_protein_glycohydrolase.csv\n Name: rat_protein_glycohydrolase.stat.csv\n URI: https://data.glygen.org/ln2wwwdata/reviewed/rat_protein_glycohydrolase.stat.csv\n\nFields\n Name: \"uniprotkb_canonical_ac\"\n Description: \"\"\n Unique Values: \"16\"\n Name: \"motif_start\"\n Description: \"\"\n Unique Values: \"23\"\n Name: \"filter_flags\"\n Description: \"Filter tags/flags assigned to the mutation entries that have passed the mutation filter criteria\"\n Unique Values: \"19\"\n Name: \"sift_prediction\"\n Description: \"The SIFT qualitative prediction is derived from this score such that substitutions with a score < 0.05 are called 'deleterious' and all others are called 'tolerated\"\n Unique Values: \"3\"\n Name: \"somatic_status\"\n Description: \"The status of the variant whether it is germline (somatic status =0) or somatic (somatic status =1) variant\"\n Unique Values: \"1\"\n Name: \"chr_pos\"\n Description: \"Chromosome Position of a gene\"\n Unique Values: \"19\"\n Name: \"chr_id\"\n Description: \"\"\n Unique Values: \"10\"\n Name: \"dbsnp_id\"\n Description: \"\"A reference SNP ID number\"\n Unique Values: \"19\"\n Name: \"evidence_ECO:0000313\"\n Description: \"A type of evidence that is imported information used in an automatic assertion\"\n Unique Values: \"1\"\n Name: \"xref_id\"\n Description: \"ID of the X-ref\"\n Unique Values: \"19\"\n Name: \"mim_id\"\n Description: \"Disease ID from the OMIM database\"\n Unique Values: \"1\"\n Name: \"description\"\n Description: \"\"\n Unique Values: \"1\"\n Name: \"begin_aa_pos\"\n Description: \"Start position of the amino acid in the sequence of a protein in UniProtKB\"\n Unique Values: \"18\"\n Name: \"cytogenic_band\"\n Description: \"One of the subregions of a chromosome visible microscopically after special staining\"\n Unique Values: \"14\"\n Name: \"aa_pos\"\n Description: \"Position of the amino acid in canonical sequence of protein in the UniProtKB database\"\n Unique Values: \"18\"\n Name: \"ref_aa\"\n Description: \"Reference amino acid residue\"\n Unique Values: \"9\"\n Name: \"sift_score\"\n Description: \"SIFT predicts whether an amino acid substitution is likely to affect protein function based on sequence homology and the physico-chemical similarity between the alternate amino acids. The data we provide for each amino acid substitution is a score and a qualitative prediction (either 'tolerated' or 'deleterious'). The score is the normalized probability that the amino acid change is tolerated so scores nearer zero are more likely to be deleterious. The qualitative prediction is derived from this score such that substitutions with a score < 0.05 are called 'deleterious' and all others are called 'tolerated\"\n Unique Values: \"10\"\n Name: \"alt_motif\"\n Description: \"Altered motif\"\n Unique Values: \"24\"\n Name: \"disease_xrefs\"\n Description: \"\"\n Unique Values: \"1\"\n Name: \"polyphen_score\"\n Description: \"The score assigned to a amino acid substitution by a tool called as PolyPhen (=Polymorphism Phenotyping) which predicts possible impact of an amino acid substitution on the structure and function of a human protein using straightforward physical and comparative considerations. The PolyPhen score ranges from 0.0 (tolerated) to 1.0 (deleterious). Variants with scores of 0.0 are predicted to be benign. Values closer to 1.0 are more confidently predicted to be deleterious\"\n Unique Values: \"1\"\n Name: \"polyphen_prediction\"\n Description: \"\"The PolyPhen prediction values are - greater than 0.908 - \"\"Probably Damaging\"\"; greater than 0.446 and less than or equal to 0.908 - \"\"Possibly Damaging\"\"; less than or equal to 0.446 - \"\"Benign\"\"\"\n Unique Values: \"1\"\n Name: \"is_known_glycoprotein\"\n Description: \"Yes or no flag to denote if a protein is experimentally proven glycoprotein\"\n Unique Values: \"1\"\n Name: \"alt_nt\"\n Description: \"Alternative nucleotide\"\n Unique Values: \"1\"\n Name: \"protein_name\"\n Description: \"Protein name in the UniProtKB\"\n Unique Values: \"16\"\n Name: \"disease_evidence_ECO:0000313\"\n Description: \"The evidence that could be a PMID or a ClinVar ID that associates disease with the variant\"\n Unique Values: \"1\"\n Name: \"effect\"\n Description: \"The effect on glycosylation or N-sequon due to variation at site of glycosylated amino acid.\"\n Unique Values: \"3\"\n Name: \"end_aa_pos\"\n Description: \"End position of the amino acid in the sequence of a protein in UniProtKB\"\n Unique Values: \"18\"\n Name: \"mutation_type\"\n Description: \"Denotes whether mutation was reported with reference to amino acid or nucleotide\"\n Unique Values: \"1\"\n Name: \"disease_description\"\n Description: \"The disease description and/or definition \"\n Unique Values: \"1\"\n Name: \"do_id\"\n Description: \"Disease Ontology identifier\"\n Unique Values: \"1\"\n Name: \"evidence_ECO:0000269\"\n Description: \"A type of experimental evidence that is used in a manual assertion. Usually the values are PMIDs\"\n Unique Values: \"1\"\n Name: \"ref_nt\"\n Description: \"Reference nucleotide\"\n Unique Values: \"4\"\n Name: \"disease\"\n Description: \"The disease name for the cell line\"\n Unique Values: \"1\"\n Name: \"alt_aa\"\n Description: \"Altered amino acid residue\"\n Unique Values: \"10\"\n Name: \"cosmic_id\"\n Description: \"Legacy mutation identifier (COSM) in Catalogue of Somatic Mutations in Cancer (COSMIC) represents existing COSM mutation identifiers. This identifier remains the same between different assemblies (GRCh37 and GRCh38). All the COSM ids at the same genomic location have been collapsed into one representative COSM id. These ids are maintained to help track existing mutations\"\n Unique Values: \"1\"\n Name: \"ref_motif\"\n Description: \"Reference motif\"\n Unique Values: \"20\"\n Name: \"xref_key\"\n Description: \"Source key associated to the xref_id\"\n Unique Values: \"2\"\n Name: \"minor_allelic_frequency\"\n Description: \"\"\n Unique Values: \"1\"\n Name: \"gene_name\"\n Description: \"\"Official gene name/symbol assigned to the gene. Human gene name/symbol are approved by the HUGO Gene Nomenclature Committee (HGNC) and mouse gene name are approved by the Mouse Genome Informatics (MGI)\"\n Unique Values: \"17\"\n Name: \"disease_evidence_ECO:0000269\"\n Description: \"The PMID evidence for the association of the disease with the variant.\"\n Unique Values: \"1\"", "downloadurl": "/ln2data/releases/data/v-1.11.2/reviewed/rat_protein_glycohydrolase.csv" }