{ "bcoid": "GLY_000575", "title": "Human Proteoform Glycation Citations (UniProtKB)", "description": "", "filename": "human_proteoform_citations_glycation_uniprotkb.csv", "filetype": "csv", "categories": { "species": "Homo sapiens", "molecule": "Proteoform", "tags": "Glycation Citations (UniProtKB)", "file_type": "csv", "status": "Reviewed", "scope": "internal" }, "minitable": { "content": [ [ "P02647-1...", "The preferen..." ], [ "P10636-1...", "Characteriza..." ] ], "headers": [ "uniprotkb_ca...", "title..." ], "colwidth": [ "40%", "20%" ] }, "sampledata": { "type": "table", "data": [ [ { "type": "string", "label": "uniprotkb_canonical_ac" }, { "type": "string", "label": "title" }, { "type": "string", "label": "journal_name" }, { "type": "string", "label": "publication_date" }, { "type": "string", "label": "authors" }, { "type": "string", "label": "xref_key" }, { "type": "string", "label": "xref_id" }, { "type": "string", "label": "src_xref_key" }, { "type": "string", "label": "src_xref_id" } ], [ "P02647-1", "The preferential site of non-enzymatic glycation of human apolipoprotein A-I in vivo.", "Clinica chimica acta; international journal of clinical chemistry", "1993 Aug 31", "Calvo C, Ulloa N, Campos M, Verdugo C, Ayrault-Jarrier M", "protein_xref_pubmed", "8261628", "protein_xref_uniprotkb_gly", "P02647" ], [ "P10636-1", "Characterization of in vitro glycation sites of tau.", "Journal of neurochemistry", "1997 Oct", "Nacharaju P, Ko L, Yen SH", "protein_xref_pubmed", "9326300", "protein_xref_uniprotkb_gly", "P10636" ], [ "P61769-1", "Glycation of human beta 2-microglobulin in patients with hemodialysis-associated amyloidosis: identification of the glycated sites.", "Biochemistry", "1994 Oct 11", "Miyata T, Inagi R, Wada Y, Ueda Y, Iida Y, Takahashi M, Taniguchi N, Maeda K", "protein_xref_pubmed", "7918443", "protein_xref_uniprotkb_gly", "P61769" ], [ "P68871-1", "Sites of nonenzymatic glycosylation of human hemoglobin A.", "The Journal of biological chemistry", "1980 Apr 10", "Shapiro R, McManus MJ, Zalut C, Bunn HF", "protein_xref_pubmed", "7358733", "protein_xref_uniprotkb_gly", "P68871" ], [ "P02768-1", "Enzymatic digestion and mass spectrometry in the study of advanced glycation end products/peptides.", "Journal of the American Society for Mass Spectrometry", "2004 Apr", "Lapolla A, Fedele D, Reitano R, Arico NC, Seraglia R, Traldi P, Marotta E, Tonani R", "protein_xref_pubmed", "15047055", "protein_xref_uniprotkb_gly", "P02768" ], [ "P69905-1", "Sites of nonenzymatic glycosylation of human hemoglobin A.", "The Journal of biological chemistry", "1980 Apr 10", "Shapiro R, McManus MJ, Zalut C, Bunn HF", "protein_xref_pubmed", "7358733", "protein_xref_uniprotkb_gly", "P69905" ], [ "Q16236-1", "The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase.", "Cell", "2019 Aug 8", "Sanghvi VR, Leibold J, Mina M, Mohan P, Berishaj M, Li Z, Miele MM, Lailler N, Zhao C, de Stanchina E, Viale A, Akkari L, Lowe SW, Ciriello G, Hendrickson RC, Wendel HG", "protein_xref_pubmed", "31398338", "protein_xref_uniprotkb_gly", "Q16236" ], [ "P02768-1", "Nonenzymatic glycosylation of albumin in vivo. Identification of multiple glycosylated sites.", "The Journal of biological chemistry", "1986 Oct 15", "Iberg N, Fluckiger R", "protein_xref_pubmed", "3759977", "protein_xref_uniprotkb_gly", "P02768" ], [ "P02768-1", "Nonenzymatic glycosylation of human serum albumin alters its conformation and function.", "The Journal of biological chemistry", "1984 Mar 25", "Shaklai N, Garlick RL, Bunn HF", "protein_xref_pubmed", "6706980", "protein_xref_uniprotkb_gly", "P02768" ], [ "P02768-1", "The principal site of nonenzymatic glycosylation of human serum albumin in vivo.", "The Journal of biological chemistry", "1983 May 25", "Garlick RL, Mazer JS", "protein_xref_pubmed", "6853480", "protein_xref_uniprotkb_gly", "P02768" ], [ "P07738-1", "Human erythrocyte bisphosphoglycerate mutase: inactivation by glycation in vivo and in vitro.", "Journal of biochemistry", "1998 Dec 1", "Fujita T, Suzuki K, Tada T, Yoshihara Y, Hamaoka R, Uchida K, Matuo Y, Sasaki T, Hanafusa T, Taniguchi N", "protein_xref_pubmed", "9832630", "protein_xref_uniprotkb_gly", "P07738" ], [ "P00751-1", "The principal site of glycation of human complement factor B.", "The Biochemical journal", "1991 Mar 1", "Niemann MA, Bhown AS, Miller EJ", "protein_xref_pubmed", "2006911", "protein_xref_uniprotkb_gly", "P00751" ], [ "P68871-1", "The glycosylation of hemoglobin: relevance to diabetes mellitus.", "Science (New York, N.Y.)", "1978 Apr 7", "Bunn HF, Gabbay KH, Gallop PM", "protein_xref_pubmed", "635569", "protein_xref_uniprotkb_gly", "P68871" ], [ "P08294-1", "The site of nonenzymic glycation of human extracellular-superoxide dismutase in vitro.", "Free radical biology & medicine", "1992 Sep", "Adachi T, Ohta H, Hayashi K, Hirano K, Marklund SL", "protein_xref_pubmed", "1505778", "protein_xref_uniprotkb_gly", "P08294" ], [ "P13987-1", "Molecular basis for a link between complement and the vascular complications of diabetes.", "Proceedings of the National Academy of Sciences of the United States of America", "2000 May 9", "Acosta J, Hettinga J, Fluckiger R, Krumrei N, Goldfine A, Angarita L, Halperin J", "protein_xref_pubmed", "10805801", "protein_xref_uniprotkb_gly", "P13987" ], [ "P02649-1", "Glycation of apolipoprotein E impairs its binding to heparin: identification of the major glycation site.", "Biochimica et biophysica acta", "1999 Aug 30", "Shuvaev VV, Fujii J, Kawasaki Y, Itoh H, Hamaoka R, Barbier A, Ziegler O, Siest G, Taniguchi N", "protein_xref_pubmed", "10452964", "protein_xref_uniprotkb_gly", "P02649" ] ] }, "readme": "Name\n - Human Proteoform Glycation Citations (UniProtKB)\n\nVersion\n - 1.11.2\n\nCreated on\n - 2021-06-04T12:34:52.072705\n\nModified on\n - 2021-06-04T13:19:24.655136\n\nCreated by\n - [jeetvora@gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Amanda Bell [amandab2140@gwu.edu], Jonathon Keeney [keeneyjg@gwu.edu], Millicent Quartey [mquartey@email.gwu.edu]\n\nAuthors\n - \n\nChecksum\n - \n\nExecution Domain\n Scripts\n\n Software Prerequisites\n\nI/O Domain\n Output Subdomain\n Name: human_proteoform_citations_glycation_uniprotkb.csv\n URI: http://data.glygen.org/ln2data/releases/data/v-1.11.2/reviewed/human_proteoform_citations_glycation_uniprotkb.csv\n Name: human_proteoform_citations_glycation_uniprotkb.stat.csv\n URI: http://data.glygen.org/ln2data/releases/data/v-1.11.2/reviewed/human_proteoform_citations_glycation_uniprotkb.stat.csv\n\nFields\n Name: \"uniprotkb_canonical_ac\"\n Description: \"\"\n Unique Values: \"16\"\n Name: \"motif_start\"\n Description: \"\"\n Unique Values: \"23\"\n Name: \"filter_flags\"\n Description: \"Filter tags/flags assigned to the mutation entries that have passed the mutation filter criteria\"\n Unique Values: \"19\"\n Name: \"sift_prediction\"\n Description: \"The SIFT qualitative prediction is derived from this score such that substitutions with a score < 0.05 are called 'deleterious' and all others are called 'tolerated\"\n Unique Values: \"3\"\n Name: \"somatic_status\"\n Description: \"The status of the variant whether it is germline (somatic status =0) or somatic (somatic status =1) variant\"\n Unique Values: \"1\"\n Name: \"chr_pos\"\n Description: \"Chromosome Position of a gene\"\n Unique Values: \"19\"\n Name: \"chr_id\"\n Description: \"\"\n Unique Values: \"10\"\n Name: \"dbsnp_id\"\n Description: \"\"A reference SNP ID number\"\n Unique Values: \"19\"\n Name: \"evidence_ECO:0000313\"\n Description: \"A type of evidence that is imported information used in an automatic assertion\"\n Unique Values: \"1\"\n Name: \"xref_id\"\n Description: \"ID of the X-ref\"\n Unique Values: \"19\"\n Name: \"mim_id\"\n Description: \"Disease ID from the OMIM database\"\n Unique Values: \"1\"\n Name: \"description\"\n Description: \"\"\n Unique Values: \"1\"\n Name: \"begin_aa_pos\"\n Description: \"Start position of the amino acid in the sequence of a protein in UniProtKB\"\n Unique Values: \"18\"\n Name: \"cytogenic_band\"\n Description: \"One of the subregions of a chromosome visible microscopically after special staining\"\n Unique Values: \"14\"\n Name: \"aa_pos\"\n Description: \"Position of the amino acid in canonical sequence of protein in the UniProtKB database\"\n Unique Values: \"18\"\n Name: \"ref_aa\"\n Description: \"Reference amino acid residue\"\n Unique Values: \"9\"\n Name: \"sift_score\"\n Description: \"SIFT predicts whether an amino acid substitution is likely to affect protein function based on sequence homology and the physico-chemical similarity between the alternate amino acids. The data we provide for each amino acid substitution is a score and a qualitative prediction (either 'tolerated' or 'deleterious'). The score is the normalized probability that the amino acid change is tolerated so scores nearer zero are more likely to be deleterious. The qualitative prediction is derived from this score such that substitutions with a score < 0.05 are called 'deleterious' and all others are called 'tolerated\"\n Unique Values: \"10\"\n Name: \"alt_motif\"\n Description: \"Altered motif\"\n Unique Values: \"24\"\n Name: \"disease_xrefs\"\n Description: \"\"\n Unique Values: \"1\"\n Name: \"polyphen_score\"\n Description: \"The score assigned to a amino acid substitution by a tool called as PolyPhen (=Polymorphism Phenotyping) which predicts possible impact of an amino acid substitution on the structure and function of a human protein using straightforward physical and comparative considerations. The PolyPhen score ranges from 0.0 (tolerated) to 1.0 (deleterious). Variants with scores of 0.0 are predicted to be benign. Values closer to 1.0 are more confidently predicted to be deleterious\"\n Unique Values: \"1\"\n Name: \"polyphen_prediction\"\n Description: \"\"The PolyPhen prediction values are - greater than 0.908 - \"\"Probably Damaging\"\"; greater than 0.446 and less than or equal to 0.908 - \"\"Possibly Damaging\"\"; less than or equal to 0.446 - \"\"Benign\"\"\"\n Unique Values: \"1\"\n Name: \"is_known_glycoprotein\"\n Description: \"Yes or no flag to denote if a protein is experimentally proven glycoprotein\"\n Unique Values: \"1\"\n Name: \"alt_nt\"\n Description: \"Alternative nucleotide\"\n Unique Values: \"1\"\n Name: \"protein_name\"\n Description: \"Protein name in the UniProtKB\"\n Unique Values: \"16\"\n Name: \"disease_evidence_ECO:0000313\"\n Description: \"The evidence that could be a PMID or a ClinVar ID that associates disease with the variant\"\n Unique Values: \"1\"\n Name: \"effect\"\n Description: \"The effect on glycosylation or N-sequon due to variation at site of glycosylated amino acid.\"\n Unique Values: \"3\"\n Name: \"end_aa_pos\"\n Description: \"End position of the amino acid in the sequence of a protein in UniProtKB\"\n Unique Values: \"18\"\n Name: \"mutation_type\"\n Description: \"Denotes whether mutation was reported with reference to amino acid or nucleotide\"\n Unique Values: \"1\"\n Name: \"disease_description\"\n Description: \"The disease description and/or definition \"\n Unique Values: \"1\"\n Name: \"do_id\"\n Description: \"Disease Ontology identifier\"\n Unique Values: \"1\"\n Name: \"evidence_ECO:0000269\"\n Description: \"A type of experimental evidence that is used in a manual assertion. Usually the values are PMIDs\"\n Unique Values: \"1\"\n Name: \"ref_nt\"\n Description: \"Reference nucleotide\"\n Unique Values: \"4\"\n Name: \"disease\"\n Description: \"The disease name for the cell line\"\n Unique Values: \"1\"\n Name: \"alt_aa\"\n Description: \"Altered amino acid residue\"\n Unique Values: \"10\"\n Name: \"cosmic_id\"\n Description: \"Legacy mutation identifier (COSM) in Catalogue of Somatic Mutations in Cancer (COSMIC) represents existing COSM mutation identifiers. This identifier remains the same between different assemblies (GRCh37 and GRCh38). All the COSM ids at the same genomic location have been collapsed into one representative COSM id. These ids are maintained to help track existing mutations\"\n Unique Values: \"1\"\n Name: \"ref_motif\"\n Description: \"Reference motif\"\n Unique Values: \"20\"\n Name: \"xref_key\"\n Description: \"Source key associated to the xref_id\"\n Unique Values: \"2\"\n Name: \"minor_allelic_frequency\"\n Description: \"\"\n Unique Values: \"1\"\n Name: \"gene_name\"\n Description: \"\"Official gene name/symbol assigned to the gene. Human gene name/symbol are approved by the HUGO Gene Nomenclature Committee (HGNC) and mouse gene name are approved by the Mouse Genome Informatics (MGI)\"\n Unique Values: \"17\"\n Name: \"disease_evidence_ECO:0000269\"\n Description: \"The PMID evidence for the association of the disease with the variant.\"\n Unique Values: \"1\"", "downloadurl": "/ln2data/releases/data/v-1.11.2/reviewed/human_proteoform_citations_glycation_uniprotkb.csv" }