{ "bcoid": "GLY_000356", "title": "HCV1b Protein Citations (UniProtKB)", "description": "The Hepatitis C virus (genotype 1b, isolate Japanese) Protein Citations dataset contains publication ...", "filename": "hcv1b_protein_citations_uniprotkb.csv", "filetype": "csv", "categories": { "species": "Hepatitis C virus (genotype 1b, isolate Japanese)", "molecule": "Protein", "tags": "Protein Citations", "file_type": "csv", "status": "Reviewed", "scope": "internal" }, "minitable": { "content": [ [ "P26662-1...", "Hepatitis C ..." ], [ "P26662-1...", "Hepatitis C ..." ] ], "headers": [ "uniprotkb_ca...", "title..." ], "colwidth": [ "40%", "20%" ] }, "sampledata": { "type": "table", "data": [ [ { "type": "string", "label": "uniprotkb_canonical_ac" }, { "type": "string", "label": "title" }, { "type": "string", "label": "journal_name" }, { "type": "string", "label": "publication_date" }, { "type": "string", "label": "authors" }, { "type": "string", "label": "xref_key" }, { "type": "string", "label": "xref_id" }, { "type": "string", "label": "src_xref_key" }, { "type": "string", "label": "src_xref_id" } ], [ "P26662-1", "Hepatitis C virus expression suppresses interferon signaling by degrading STAT1.", "Gastroenterology", "2005", "Lin W., Chung R.T., Blackard J.T., Choe W.H., Hiasa Y., Kamegaya Y., Schmidt E.V.", "protein_xref_pubmed", "15825084", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Hepatitis C virus non-structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells.", "FEBS Lett.", "2006", "Chen L., Hu Y., Wang J., Zhang X., Pan T., Yuan Z., Yi Z., Xiang L., Tong W.", "protein_xref_pubmed", "16844119", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus.", "Mol. Cell. Biol.", "2003", "Doi T., Shimotohno K., Hijikata M., Marusawa H., Tagawa A., Watashi K.", "protein_xref_pubmed", "14559998", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B.", "J. Virol.", "2005", "Liu M., Matsuura Y., Okamoto T., Suzuki T., Abe T., Mori Y., Nishimura Y., Moriishi K., Miyamura T., Lai M.M., Aizaki H., Hamamoto I.", "protein_xref_pubmed", "16227268", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis.", "Proc. Natl. Acad. Sci. U.S.A.", "1991", "Kato N., Shimotohno K., Hijikata M., Nakagawa M., Ootsuyama Y.", "protein_xref_pubmed", "1648221", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "The NS5A protein of the hepatitis C virus genotype 1a is cleaved by caspases to produce C-terminal-truncated forms of the protein that reside mainly in the cytosol.", "J. Biol. Chem.", "2006", "Georgopoulou U., Kalamvoki M., Mavromara P.", "protein_xref_pubmed", "16517592", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "HCV NS3 protein helicase domain assists RNA structure conversion.", "FEBS Lett.", "2010", "Wang C.C., Huang Z.S., Wu H.N.", "protein_xref_pubmed", "20398661", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "NMR structure and ion channel activity of the p7 protein from hepatitis C virus.", "J. Biol. Chem.", "2010", "Simorre J.P., Dubuisson J., Pietschmann T., Ebel C., Vanbelle C., Montserret R., Penin F., Sapay N., Bockmann A., Chipot C., Renisio J.G., Saint N., Salvay A.G., Steinmann E.", "protein_xref_pubmed", "20667830", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine.", "Nat. Chem. Biol.", "2011", "Singh J., Zhu Z., Chaturvedi P., Nacht M., Qiao L., Niu D., Hagel M., Westlin W.F., Bernard H., Karp R.M., Labenski M.T., Petter R.C., Sheets M.P., St Martin T.", "protein_xref_pubmed", "21113170", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335.", "J. Biol. Chem.", "2011", "Zhao S., Goudreau N., Hucke O., Lemke C.T., Llinas-Brunet M., Thibeault D., White P.W.", "protein_xref_pubmed", "21270126", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "High affinity peptide inhibitors of the hepatitis C virus NS3-4A protease refractory to common resistant mutants.", "J. Biol. Chem.", "2012", "van den Heuvel J., Collins J., Heinz D.W., Franke R., Pietschmann T., Gentzsch J., Haid S., Kugler J., Pollmann E., Schmelz S.", "protein_xref_pubmed", "22965230", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Molecular mechanism by which a potent hepatitis C virus NS3-NS4A protease inhibitor overcomes emergence of resistance.", "J. Biol. Chem.", "2013", "Lagace L., Godbout C., Kukolj G., Lemke C.T., Llinas-Brunet M., Moreau B., O'Meara J.A., Thibeault D., White P.W.", "protein_xref_pubmed", "23271737", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Regulation of hepatitis C virus replication by nuclear translocation of nonstructural 5A protein and transcriptional activation of host genes.", "J. Virol.", "2013", "Higgs M.R., Maqbool M.A., Carmouse S., Imache M.R., Lerat H., Pawlotsky J.M.", "protein_xref_pubmed", "23468497", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Discovery of danoprevir (ITMN-191/R7227), a highly selective and potent inhibitor of hepatitis C virus (HCV) NS3/4A protease.", "J. Med. Chem.", "2014", "Wang B., Zhang H., Jiang Y., Brandhuber B.J., Stengel P., Lyon M., Kennedy A.L., Andrews S.W., Ballard J., Beigelman L., Blatt L., Buckman B., Condroski K.R., Doherty G.A., Geck Do M., Josey J.A., Lemieux C., Madduru M.R., Seiwert S.D., Serebryany V., Vigers G., Wenglowsky S., Woodard B.T.", "protein_xref_pubmed", "23672640", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Phosphorylation of hepatitis C virus RNA polymerases ser29 and ser42 by protein kinase C-related kinase 2 regulates viral RNA replication.", "J. Virol.", "2014", "Kim S.J., Lee S.H., Han S.H., Cho K., Kim T.E., Kim E.J., Kim G.W., Oh J.W., Moon J.S., Yoo J.S., Han S.H.', Rhee J.K., Son W.S.", "protein_xref_pubmed", "25031343", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "HCV NS5A hyperphosphorylation is involved in viral translation modulation.", "Biochem. Biophys. Res. Commun.", "2019", "Liu Q., Kandangwa M.", "protein_xref_pubmed", "31585734", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "The N-terminal region of hepatitis C virus-encoded NS5A is important for NS4A-dependent phosphorylation.", "J. Virol.", "1997", "Kimura K., Shimotohno K., Kaneko T., Satoh S., Tanji Y., Asabe S.I.", "protein_xref_pubmed", "8985418", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Inhibition of the hepatitis C virus NS3/4A protease. The crystal structures of two protease-inhibitor complexes.", "J. Biol. Chem.", "2000", "Rizzi M., Walsh M.A., Di Marco S., De Francesco R., Volpari C., Colarusso S., Matassa V.G., Narjes F., Sollazzo M.", "protein_xref_pubmed", "10702283", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Cleavage of hepatitis C virus nonstructural protein 5A by a caspase-like protease(s) in mammalian cells.", "Virology", "2000", "Shimotohno K., Hijikata M., Noguchi T., Handa H., Satoh S., Hirota M.", "protein_xref_pubmed", "10793006", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Oligomerization and cooperative RNA synthesis activity of hepatitis C virus RNA-dependent RNA polymerase.", "J. Virol.", "2002", "Lu J., Zhang F., Rathnachalam R., Kirkegaard K., Staschke K., Parsons S., Wang Q.M., Case K.A., Colacino J.M., Hockman M.A., Johnson R.B.", "protein_xref_pubmed", "11907226", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Intramembrane proteolysis and endoplasmic reticulum retention of hepatitis C virus core protein.", "J. Virol.", "2004", "Matsuura Y., Moriishi K., Okamoto K., Miyamura T.", "protein_xref_pubmed", "15163730", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "The design and enzyme-bound crystal structure of indoline based peptidomimetic inhibitors of hepatitis C virus NS3 protease.", "J. Med. Chem.", "2004", "Di Marco S., Conte I., Steinkuehler C., Volpari C., Harper S., Koch U., Di Francesco M.E., Gardelli C., Matassa V.G., Ontoria J.M., Poma M.", "protein_xref_pubmed", "15588076", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Molecular determinants for subcellular localization of hepatitis C virus core protein.", "J. Virol.", "2005", "Matsuura Y., Suzuki T., Tanaka K., Mizumoto K., Suzuki R., Moriishi K., Sakamoto S., Iwasaki T., Tsutsumi T., Miyamura T., Shimoike T., Rikimaru A.", "protein_xref_pubmed", "15613354", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Hepatitis C virus core protein acts as a trans-modulating factor on internal translation initiation of the viral RNA.", "J. Biol. Chem.", "2005", "Boulant S., Cahour A., Boni S., Lavergne J.-P.", "protein_xref_pubmed", "15760888", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding protein.", "J. Biol. Chem.", "2005", "Chen Y., Huang L., Hwang J., Sharma S.D., Arnold J.J., Cameron C.E., Hargittai M.R., Raney K.D.", "protein_xref_pubmed", "16126720", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain.", "J. Virol.", "2006", "Lin W., Kim S.S., Holtzman M.J., Kim K.A., Chung R.T., Blackard J.T., Kamegaya Y., Yeung E.", "protein_xref_pubmed", "16940534", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Molecular structure of the Japanese hepatitis C viral genome.", "FEBS Lett.", "1991", "Kato N., Shimotohno K., Hijikata M., Nakagawa M., Muraiso K., Ohkoshi S., Ootsuyama Y.", "protein_xref_pubmed", "1849488", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis.", "Proc. Natl. Acad. Sci. U.S.A.", "1990", "Kato N., Shimotohno K., Hijikata M., Sugimura T., Nakagawa M., Ohkoshi S., Ootsuyama Y.", "protein_xref_pubmed", "2175903", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Mass spectrometric analysis of hepatitis C viral envelope protein E2 reveals extended microheterogeneity of mucin-type O-linked glycosylation.", "Glycobiology", "2013", "Scheidig A.J., Egge-Jacobsen W., Braeutigam J.", "protein_xref_pubmed", "23242014", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A.", "J. Virol.", "1995", "Shimotohno K., Kaneko T., Satoh S., Tanji Y.", "protein_xref_pubmed", "7769656", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome.", "Biochem. Biophys. Res. Commun.", "1994", "Kimura K., Shimotohno K., Kaneko T., Hijikata M., Satoh S., Asabe S., Tanji Y.", "protein_xref_pubmed", "7999043", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions.", "J. Virol.", "1993", "Jacobsen H., Bartenschlager R., Mous J., Ahlborn-Laake L.", "protein_xref_pubmed", "8389908", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus.", "J. Virol.", "1993", "Kato N., Kimura K., Shimotohno K., Tanaka T., Hijikata M., Mori S., Mizushima H., Akagi T., Kakiuchi N.", "protein_xref_pubmed", "8392606", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells.", "J. Virol.", "1993", "Chen S.-Y., Miyamura T., Lee Y.-H.W., Lo S.J., Shih C.-M.", "protein_xref_pubmed", "8396658", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "The NS3 proteinase domain of hepatitis C virus is a zinc-containing enzyme.", "J. Virol.", "1997", "Hostomska Z., Hostomsky Z., Nodes B.R., Stempniak M.", "protein_xref_pubmed", "9060645", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator.", "J. Virol.", "1997", "Kato N., Omata M., Shiratori Y., Lan K.H., Ono-Nita S.K.", "protein_xref_pubmed", "9343247", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Interferon resistance of hepatitis C virus genotype 1b: relationship to nonstructural 5A gene quasispecies mutations.", "J. Virol.", "1998", "Frainais P.-O., Germanidis G., Pawlotsky J.-M., Dhumeaux D., Neumann A.U., Pellerin M.", "protein_xref_pubmed", "9525599", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "The native form and maturation process of hepatitis C virus core protein.", "J. Virol.", "1998", "Wands J.R., Ichikawa M., Funahashi S., Yasui K., Wakita T., Moradpour D., Kohara M., Kajita T., Tsukiyama-Kohara K.", "protein_xref_pubmed", "9621068", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes.", "J. Viral Hepat.", "2000", "McLauchlan J.", "protein_xref_pubmed", "10718937", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Structural biology of hepatitis C virus.", "Hepatology", "2004", "Dubuisson J., Rey F.A., Moradpour D., Pawlotsky J.-M., Penin F.", "protein_xref_pubmed", "14752815", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets.", "PLoS Pathog.", "2013", "Wang H., Parton R.G., Ferguson C., Salloum S., Tai A.W.", "protein_xref_pubmed", "23935497", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Mapping of the interacting domains of hepatitis C virus core protein and the double-stranded RNA-activated protein kinase PKR.", "Virus Res.", "2007", "Chen Z., Brechot C., Battaglia S., Boucreux D., Pavio N., Yan X.B.", "protein_xref_pubmed", "17267064", "protein_xref_uniprotkb", "P26662" ], [ "P26662-1", "Quasispecies evolution in NS5A region of hepatitis C virus genotype 1b during interferon or combined interferon-ribavirin therapy.", "World J. Gastroenterol.", "2007", "Gaudy C., Le Guillou-Guillemette H., Lunel F., Payan C., Veillon P.", "protein_xref_pubmed", "17451199", "protein_xref_uniprotkb", "P26662" ] ] }, "readme": "Name\n - HCV1b Protein Citations (UniProtKB)\n\nVersion\n - 1.11.2\n\nCreated on\n - 2020-03-13T14:12:07.407873\n\nModified on\n - 2020-04-09T18:03:43.664394\n\nCreated by\n - Jeet Vora [jeetvora@gwu.edu], Rahi Navelkar [rsn13@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Amanda Bell [amandab2140@gwu.edu], Jonathon Keeney [keeneyjg@gwu.edu], Millicent Quartey [mquartey@email.gwu.edu]\n\nAuthors\n - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n - \n\nUsability Domain\n - The Hepatitis C virus (genotype 1b, isolate Japanese) Protein Citations dataset contains publication information for hcv1b [taxid:11116] UniProtKB accessions that includes PMID, journal name, date and author and title. The dataset is derived from 2019-09 UniProt release. If you use this dataset please provide proper attribution to EMBL-EBI-UniProtKB and GlyGen\n\nDescription Domain\n Keywords\n - publications\n - PMID\n - journal\n - citations\n - authors\n - UniProtKB\n - PubMed\n\n Pipeline Steps\n - Step-1: The script loads the UniProtKB publication data from the triplestore containing triples from nt file to retrieve the publication information associated with the UniProtKB accession and maps it to the UniProtKB canonical accessions.\n\nExecution Domain\n Scripts - https://github.com/GW-HIVE/glygen-backend-integration/blob/master/pipeline/integrator/make-protein-dataset.py\n\n\n Software Prerequisites\n Name: Python\n Version: 2.7.5\n URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n Input Subdomain\n Name: uniprot-proteome-hepatitis-c-virus-1b.nt\n URI: https://data.glygen.org/ln2data/releases/data/v-1.11.2/source/uniprot-proteome-hepatitis-c-virus-1b.nt\n Name: hcv1b_protein_masterlist.csv\n URI: https://data.glygen.org/ln2data/releases/data/v-1.11.2/reviewed/hcv1b_protein_masterlist.csv\n Output Subdomain\n Name: hcv1b_protein_citations_uniprotkb.csv\n URI: http://data.glygen.org/ln2data/releases/data/v-1.11.2/reviewed/hcv1b_protein_citations_uniprotkb.csv\n Name: hcv1b_protein_citations_uniprotkb.stat.csv\n URI: http://data.glygen.org/ln2data/releases/data/v-1.11.2/reviewed/hcv1b_protein_citations_uniprotkb.stat.csv\n\nFields\n Name: \"uniprotkb_canonical_ac\"\n Description: \"\"\n Unique Values: \"16\"\n Name: \"motif_start\"\n Description: \"\"\n Unique Values: \"23\"\n Name: \"filter_flags\"\n Description: \"Filter tags/flags assigned to the mutation entries that have passed the mutation filter criteria\"\n Unique Values: \"19\"\n Name: \"sift_prediction\"\n Description: \"The SIFT qualitative prediction is derived from this score such that substitutions with a score < 0.05 are called 'deleterious' and all others are called 'tolerated\"\n Unique Values: \"3\"\n Name: \"somatic_status\"\n Description: \"The status of the variant whether it is germline (somatic status =0) or somatic (somatic status =1) variant\"\n Unique Values: \"1\"\n Name: \"chr_pos\"\n Description: \"Chromosome Position of a gene\"\n Unique Values: \"19\"\n Name: \"chr_id\"\n Description: \"\"\n Unique Values: \"10\"\n Name: \"dbsnp_id\"\n Description: \"\"A reference SNP ID number\"\n Unique Values: \"19\"\n Name: \"evidence_ECO:0000313\"\n Description: \"A type of evidence that is imported information used in an automatic assertion\"\n Unique Values: \"1\"\n Name: \"xref_id\"\n Description: \"ID of the X-ref\"\n Unique Values: \"19\"\n Name: \"mim_id\"\n Description: \"Disease ID from the OMIM database\"\n Unique Values: \"1\"\n Name: \"description\"\n Description: \"\"\n Unique Values: \"1\"\n Name: \"begin_aa_pos\"\n Description: \"Start position of the amino acid in the sequence of a protein in UniProtKB\"\n Unique Values: \"18\"\n Name: \"cytogenic_band\"\n Description: \"One of the subregions of a chromosome visible microscopically after special staining\"\n Unique Values: \"14\"\n Name: \"aa_pos\"\n Description: \"Position of the amino acid in canonical sequence of protein in the UniProtKB database\"\n Unique Values: \"18\"\n Name: \"ref_aa\"\n Description: \"Reference amino acid residue\"\n Unique Values: \"9\"\n Name: \"sift_score\"\n Description: \"SIFT predicts whether an amino acid substitution is likely to affect protein function based on sequence homology and the physico-chemical similarity between the alternate amino acids. The data we provide for each amino acid substitution is a score and a qualitative prediction (either 'tolerated' or 'deleterious'). The score is the normalized probability that the amino acid change is tolerated so scores nearer zero are more likely to be deleterious. The qualitative prediction is derived from this score such that substitutions with a score < 0.05 are called 'deleterious' and all others are called 'tolerated\"\n Unique Values: \"10\"\n Name: \"alt_motif\"\n Description: \"Altered motif\"\n Unique Values: \"24\"\n Name: \"disease_xrefs\"\n Description: \"\"\n Unique Values: \"1\"\n Name: \"polyphen_score\"\n Description: \"The score assigned to a amino acid substitution by a tool called as PolyPhen (=Polymorphism Phenotyping) which predicts possible impact of an amino acid substitution on the structure and function of a human protein using straightforward physical and comparative considerations. The PolyPhen score ranges from 0.0 (tolerated) to 1.0 (deleterious). Variants with scores of 0.0 are predicted to be benign. Values closer to 1.0 are more confidently predicted to be deleterious\"\n Unique Values: \"1\"\n Name: \"polyphen_prediction\"\n Description: \"\"The PolyPhen prediction values are - greater than 0.908 - \"\"Probably Damaging\"\"; greater than 0.446 and less than or equal to 0.908 - \"\"Possibly Damaging\"\"; less than or equal to 0.446 - \"\"Benign\"\"\"\n Unique Values: \"1\"\n Name: \"is_known_glycoprotein\"\n Description: \"Yes or no flag to denote if a protein is experimentally proven glycoprotein\"\n Unique Values: \"1\"\n Name: \"alt_nt\"\n Description: \"Alternative nucleotide\"\n Unique Values: \"1\"\n Name: \"protein_name\"\n Description: \"Protein name in the UniProtKB\"\n Unique Values: \"16\"\n Name: \"disease_evidence_ECO:0000313\"\n Description: \"The evidence that could be a PMID or a ClinVar ID that associates disease with the variant\"\n Unique Values: \"1\"\n Name: \"effect\"\n Description: \"The effect on glycosylation or N-sequon due to variation at site of glycosylated amino acid.\"\n Unique Values: \"3\"\n Name: \"end_aa_pos\"\n Description: \"End position of the amino acid in the sequence of a protein in UniProtKB\"\n Unique Values: \"18\"\n Name: \"mutation_type\"\n Description: \"Denotes whether mutation was reported with reference to amino acid or nucleotide\"\n Unique Values: \"1\"\n Name: \"disease_description\"\n Description: \"The disease description and/or definition \"\n Unique Values: \"1\"\n Name: \"do_id\"\n Description: \"Disease Ontology identifier\"\n Unique Values: \"1\"\n Name: \"evidence_ECO:0000269\"\n Description: \"A type of experimental evidence that is used in a manual assertion. Usually the values are PMIDs\"\n Unique Values: \"1\"\n Name: \"ref_nt\"\n Description: \"Reference nucleotide\"\n Unique Values: \"4\"\n Name: \"disease\"\n Description: \"The disease name for the cell line\"\n Unique Values: \"1\"\n Name: \"alt_aa\"\n Description: \"Altered amino acid residue\"\n Unique Values: \"10\"\n Name: \"cosmic_id\"\n Description: \"Legacy mutation identifier (COSM) in Catalogue of Somatic Mutations in Cancer (COSMIC) represents existing COSM mutation identifiers. This identifier remains the same between different assemblies (GRCh37 and GRCh38). All the COSM ids at the same genomic location have been collapsed into one representative COSM id. These ids are maintained to help track existing mutations\"\n Unique Values: \"1\"\n Name: \"ref_motif\"\n Description: \"Reference motif\"\n Unique Values: \"20\"\n Name: \"xref_key\"\n Description: \"Source key associated to the xref_id\"\n Unique Values: \"2\"\n Name: \"minor_allelic_frequency\"\n Description: \"\"\n Unique Values: \"1\"\n Name: \"gene_name\"\n Description: \"\"Official gene name/symbol assigned to the gene. Human gene name/symbol are approved by the HUGO Gene Nomenclature Committee (HGNC) and mouse gene name are approved by the Mouse Genome Informatics (MGI)\"\n Unique Values: \"17\"\n Name: \"disease_evidence_ECO:0000269\"\n Description: \"The PMID evidence for the association of the disease with the variant.\"\n Unique Values: \"1\"", "downloadurl": "/ln2data/releases/data/v-1.11.2/reviewed/hcv1b_protein_citations_uniprotkb.csv" }