{ "bcoid": "GLY_000325", "title": "Rat Protein Enzyme Annotation (UniProtKB)", "description": "The Rat Protein Enzyme Annotation (UniProtKB) dataset contains rat [taxid:10116] enzyme annotations for ...", "filename": "rat_protein_enzyme_annotation_uniprotkb.csv", "filetype": "csv", "categories": { "species": "Rattus norvegicus", "molecule": "Protein", "tags": "enzyme annotation", "file_type": "csv", "status": "Reviewed", "scope": "internal" }, "minitable": { "content": [ [ "D4A584-1...", "2.7.10.2..." ], [ "D4A584-1...", "2.7.10.2..." ] ], "headers": [ "uniprotkb_ca...", "enzyme_ec..." ], "colwidth": [ "40%", "20%" ] }, "sampledata": { "type": "table", "data": [ [ { "type": "string", "label": "uniprotkb_canonical_ac" }, { "type": "string", "label": "enzyme_ec" }, { "type": "string", "label": "enzyme_activity" } ], [ "D4A584-1", "2.7.10.2", "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." ], [ "D4A584-1", "2.7.10.2", "" ], [ "D4A628-1", "2.7.7.7", "Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." ], [ "D4A628-1", "2.7.7.7", "" ], [ "A0A0G2K0H9-1", "3.6.4.12", "ATP + H(2)O = ADP + phosphate." ], [ "A0A0G2K0H9-1", "3.6.4.12", "" ], [ "Q5RJK3-1", "2.1.1.221", "S-adenosyl-L-methionine + guanine(9) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(9) in tRNA." ], [ "Q5RJK3-1", "2.1.1.221", "" ], [ "P30349-1", "3.3.2.6", "(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate." ], [ "P30349-1", "3.4.11.4", "Release of the N-terminal residue from a tripeptide." ], [ "P30349-1", "3.3.2.6", "" ], [ "Q9WUW8-1", "2.8.2.-", "" ], [ "P31214-1", "1.3.1.22", "A 3-oxo-5-alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + NADPH." ], [ "P31214-1", "1.3.1.22", "" ], [ "P13697-1", "1.1.1.40", "Oxaloacetate = pyruvate + CO(2)." ], [ "P13697-1", "1.1.1.40", "" ], [ "Q6MG55-1", "3.1.1.23", "Hydrolyzes glycerol monoesters of long-chain fatty acids." ], [ "Q6MG55-1", "3.1.-.-", "" ], [ "P05178-1", "1.14.14.1", "RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O." ], [ "P05178-1", "1.14.14.1", "" ], [ "Q62844-1", "2.7.10.2", "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." ], [ "Q62844-1", "2.7.10.2", "" ], [ "Q02769-1", "2.5.1.21", "2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)(+)." ], [ "Q02769-1", "2.5.1.21", "" ], [ "Q5BKD0-1", "2.7.7.84", "3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate." ], [ "Q5BKD0-1", "2.7.7.84", "" ], [ "Q5RJZ1-1", "3.6.4.12", "ATP + H(2)O = ADP + phosphate." ], [ "Q5RJZ1-1", "3.6.4.12", "" ], [ "P11980-1", "2.7.1.40", "ATP + pyruvate = ADP + phosphoenolpyruvate." ], [ "P11980-1", "2.7.1.40", "" ], [ "O35532-1", "1.14.18.9", "4,4-dimethyl-5-alpha-cholest-7-en-3-beta-ol + 6 ferrocytochrome b5 + 3 O(2) + 6 H(+) = 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carboxylate + 6 ferricytochrome b5 + 4 H(2)O." ], [ "O35532-1", "1.14.18.9", "" ], [ "D4A7E8-1", "1.5.1.20", "5-methyltetrahydrofolate + NAD(P)(+) = 5,10-methylenetetrahydrofolate + NAD(P)H." ], [ "D4A7E8-1", "1.5.1.20", "" ], [ "Q9WUD9-1", "2.7.10.2", "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." ], [ "Q9WUD9-1", "2.7.10.2", "" ], [ "D3ZN41-1", "7.6.2.1", "ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)." ], [ "D3ZN41-1", "7.6.2.1", "" ], [ "Q7TNK6-1", "2.1.1.-", "" ], [ "D3ZN47-1", "2.7.1.30", "ATP + glycerol = ADP + sn-glycerol 3-phosphate." ], [ "D3ZN47-1", "2.7.1.30", "" ], [ "P31210-1", "1.3.1.3", "5-beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + NADPH." ], [ "P31210-1", "1.3.1.3", "" ], [ "P20717-1", "3.5.3.15", "Protein L-arginine + H(2)O = protein L-citrulline + NH(3)." ], [ "P20717-1", "3.5.3.15", "" ], [ "O08874-1", "2.7.11.13", "ATP + a protein = ADP + a phosphoprotein." ], [ "O08874-1", "2.7.11.13", "" ], [ "Q6AXV9-1", "1.20.4.2", "Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O." ], [ "Q6AXV9-1", "1.8.5.1", "2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate." ], [ "Q6AXV9-1", "2.5.1.18", "RX + glutathione = HX + R-S-glutathione." ], [ "Q6AXV9-1", "2.5.1.18", "" ], [ "Q6AXV9-1", "1.8.5.1", "" ], [ "Q6AXV9-1", "1.20.4.2", "" ], [ "Q9QYG8-1", "2.7.1.48", "ATP + cytidine = ADP + CMP." ], [ "Q9QYG8-1", "2.7.1.48", "" ], [ "D3ZC66-1", "2.4.1.-", "" ], [ "O88483-1", "3.1.3.43", "[Pyruvate dehydrogenase (acetyl-transferring)] phosphate + H(2)O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate." ], [ "O88483-1", "3.1.3.43", "" ], [ "Q5M9G0-1", "3.5.4.12", "dCMP + H(2)O = dUMP + NH(3)." ], [ "Q5M9G0-1", "3.5.4.12", "" ], [ "A0A0G2KA92-1", "3.6.4.12", "ATP + H(2)O = ADP + phosphate." ], [ "A0A0G2KA92-1", "3.6.4.12", "" ], [ "Q08603-1", "2.5.1.60", "Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate." ], [ "Q08603-1", "2.5.1.60", "" ], [ "Q5RKI1-1", "3.6.4.13", "ATP + H(2)O = ADP + phosphate." ], [ "Q5RKI1-1", "3.6.4.13", "" ], [ "M0R412-1", "3.2.1.-", "" ], [ "Q63562-1", "2.7.11.25", "ATP + a protein = ADP + a phosphoprotein." ], [ "Q63562-1", "2.7.11.25", "" ], [ "D3ZD07-1", "1.14.13.8", "N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O." ], [ "D3ZD07-1", "1.14.13.8", "" ], [ "P69060-1", "2.7.7.43", "CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate." ], [ "P69060-1", "2.7.7.43", "" ], [ "Q9EQS0-1", "2.2.1.2", "Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate." ], [ "Q9EQS0-1", "2.2.1.2", "" ], [ "D3ZD03-1", "2.7.10.2", "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." ], [ "D3ZD03-1", "2.7.10.2", "" ], [ "M0RAB1-1", "7.2.2.-", "" ], [ "Q32Q05-1", "3.4.19.12", "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)." ], [ "Q32Q05-1", "3.4.19.12", "" ], [ "M0RCZ9-1", "5.2.1.8", "Peptidylproline (omega=180) = peptidylproline (omega=0)." ], [ "M0RCZ9-1", "5.2.1.8", "" ], [ "Q3SWT6-1", "3.1.3.16", "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." ], [ "Q3SWT6-1", "3.1.3.16", "" ] ] }, "readme": "Name\n - Rat Protein Enzyme Annotation (UniProtKB)\n\nVersion\n - 1.11.2\n\nCreated on\n - 2019-12-01T16:01:52.242488\n\nModified on\n - 2022-01-12T16:26:23.438038\n\nCreated by\n - Jeet Vora [jeetvora@gwu.edu], Rahi Navelkar [rsn13@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Xavier Holmes [xavierh@email.gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Amanda Bell [amandab2140@gwu.edu], Jonathon Keeney [keeneyjg@gwu.edu], Millicent Quartey [mquartey@email.gwu.edu]\n\nAuthors\n - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n - \n\nUsability Domain\n - The Rat Protein Enzyme Annotation (UniProtKB) dataset contains rat [taxid:10116] enzyme annotations for UniProtKB canonical accessions. The dataset contains ec numbers and enzyme activity that describes the enzymatic reactions. The dataset is derived form 2019-09 UniprotKB release. If you use this dataset please give proper attribution to UniProtKB and GlyGen\n\nDescription Domain\n Keywords\n - enzyme annotation\n - enzyme \n - UniProtKB\n - enzyme activity\n - EC number\n\n Pipeline Steps\n - Step-1: The script extracts the enzyme annotation triples from the triplestore for the UniProtKB canonical sequences and extracts as a dataset in a csv format\n\nExecution Domain\n Scripts - https://github.com/GW-HIVE/glygen-backend-integration/blob/master/pipeline/integrator/make-protein-dataset.py\n\n\n Software Prerequisites\n Name: Python\n Version: 2.7.5\n URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n Input Subdomain\n Name: uniprot-proteome-rattus-norvegicus.nt\n URI: https://data.glygen.org/ln2data/releases/data/v-1.11.2/reviewed/uniprot-proteome-rattus-norvegicus.nt\n Name: rat_protein_masterlist.csv\n URI: https://data.glygen.org/ln2data/releases/data/v-1.11.2/reviewed/rat_protein_masterlist.csv\n Output Subdomain\n Name: rat_protein_enzyme_annotation_uniprotkb.csv\n URI: http://data.glygen.org/ln2data/releases/data/v-1.11.2/reviewed/rat_protein_enzyme_annotation_uniprotkb.csv\n Name: rat_protein_enzyme_annotation_uniprotkb.stat.csv\n URI: http://data.glygen.org/ln2data/releases/data/v-1.11.2/reviewed/rat_protein_enzyme_annotation_uniprotkb.stat.csv\n\nFields\n Name: \"uniprotkb_canonical_ac\"\n Description: \"\"\n Unique Values: \"16\"\n Name: \"motif_start\"\n Description: \"\"\n Unique Values: \"23\"\n Name: \"filter_flags\"\n Description: \"Filter tags/flags assigned to the mutation entries that have passed the mutation filter criteria\"\n Unique Values: \"19\"\n Name: \"sift_prediction\"\n Description: \"The SIFT qualitative prediction is derived from this score such that substitutions with a score < 0.05 are called 'deleterious' and all others are called 'tolerated\"\n Unique Values: \"3\"\n Name: \"somatic_status\"\n Description: \"The status of the variant whether it is germline (somatic status =0) or somatic (somatic status =1) variant\"\n Unique Values: \"1\"\n Name: \"chr_pos\"\n Description: \"Chromosome Position of a gene\"\n Unique Values: \"19\"\n Name: \"chr_id\"\n Description: \"\"\n Unique Values: \"10\"\n Name: \"dbsnp_id\"\n Description: \"\"A reference SNP ID number\"\n Unique Values: \"19\"\n Name: \"evidence_ECO:0000313\"\n Description: \"A type of evidence that is imported information used in an automatic assertion\"\n Unique Values: \"1\"\n Name: \"xref_id\"\n Description: \"ID of the X-ref\"\n Unique Values: \"19\"\n Name: \"mim_id\"\n Description: \"Disease ID from the OMIM database\"\n Unique Values: \"1\"\n Name: \"description\"\n Description: \"\"\n Unique Values: \"1\"\n Name: \"begin_aa_pos\"\n Description: \"Start position of the amino acid in the sequence of a protein in UniProtKB\"\n Unique Values: \"18\"\n Name: \"cytogenic_band\"\n Description: \"One of the subregions of a chromosome visible microscopically after special staining\"\n Unique Values: \"14\"\n Name: \"aa_pos\"\n Description: \"Position of the amino acid in canonical sequence of protein in the UniProtKB database\"\n Unique Values: \"18\"\n Name: \"ref_aa\"\n Description: \"Reference amino acid residue\"\n Unique Values: \"9\"\n Name: \"sift_score\"\n Description: \"SIFT predicts whether an amino acid substitution is likely to affect protein function based on sequence homology and the physico-chemical similarity between the alternate amino acids. The data we provide for each amino acid substitution is a score and a qualitative prediction (either 'tolerated' or 'deleterious'). The score is the normalized probability that the amino acid change is tolerated so scores nearer zero are more likely to be deleterious. The qualitative prediction is derived from this score such that substitutions with a score < 0.05 are called 'deleterious' and all others are called 'tolerated\"\n Unique Values: \"10\"\n Name: \"alt_motif\"\n Description: \"Altered motif\"\n Unique Values: \"24\"\n Name: \"disease_xrefs\"\n Description: \"\"\n Unique Values: \"1\"\n Name: \"polyphen_score\"\n Description: \"The score assigned to a amino acid substitution by a tool called as PolyPhen (=Polymorphism Phenotyping) which predicts possible impact of an amino acid substitution on the structure and function of a human protein using straightforward physical and comparative considerations. The PolyPhen score ranges from 0.0 (tolerated) to 1.0 (deleterious). Variants with scores of 0.0 are predicted to be benign. Values closer to 1.0 are more confidently predicted to be deleterious\"\n Unique Values: \"1\"\n Name: \"polyphen_prediction\"\n Description: \"\"The PolyPhen prediction values are - greater than 0.908 - \"\"Probably Damaging\"\"; greater than 0.446 and less than or equal to 0.908 - \"\"Possibly Damaging\"\"; less than or equal to 0.446 - \"\"Benign\"\"\"\n Unique Values: \"1\"\n Name: \"is_known_glycoprotein\"\n Description: \"Yes or no flag to denote if a protein is experimentally proven glycoprotein\"\n Unique Values: \"1\"\n Name: \"alt_nt\"\n Description: \"Alternative nucleotide\"\n Unique Values: \"1\"\n Name: \"protein_name\"\n Description: \"Protein name in the UniProtKB\"\n Unique Values: \"16\"\n Name: \"disease_evidence_ECO:0000313\"\n Description: \"The evidence that could be a PMID or a ClinVar ID that associates disease with the variant\"\n Unique Values: \"1\"\n Name: \"effect\"\n Description: \"The effect on glycosylation or N-sequon due to variation at site of glycosylated amino acid.\"\n Unique Values: \"3\"\n Name: \"end_aa_pos\"\n Description: \"End position of the amino acid in the sequence of a protein in UniProtKB\"\n Unique Values: \"18\"\n Name: \"mutation_type\"\n Description: \"Denotes whether mutation was reported with reference to amino acid or nucleotide\"\n Unique Values: \"1\"\n Name: \"disease_description\"\n Description: \"The disease description and/or definition \"\n Unique Values: \"1\"\n Name: \"do_id\"\n Description: \"Disease Ontology identifier\"\n Unique Values: \"1\"\n Name: \"evidence_ECO:0000269\"\n Description: \"A type of experimental evidence that is used in a manual assertion. Usually the values are PMIDs\"\n Unique Values: \"1\"\n Name: \"ref_nt\"\n Description: \"Reference nucleotide\"\n Unique Values: \"4\"\n Name: \"disease\"\n Description: \"The disease name for the cell line\"\n Unique Values: \"1\"\n Name: \"alt_aa\"\n Description: \"Altered amino acid residue\"\n Unique Values: \"10\"\n Name: \"cosmic_id\"\n Description: \"Legacy mutation identifier (COSM) in Catalogue of Somatic Mutations in Cancer (COSMIC) represents existing COSM mutation identifiers. This identifier remains the same between different assemblies (GRCh37 and GRCh38). All the COSM ids at the same genomic location have been collapsed into one representative COSM id. These ids are maintained to help track existing mutations\"\n Unique Values: \"1\"\n Name: \"ref_motif\"\n Description: \"Reference motif\"\n Unique Values: \"20\"\n Name: \"xref_key\"\n Description: \"Source key associated to the xref_id\"\n Unique Values: \"2\"\n Name: \"minor_allelic_frequency\"\n Description: \"\"\n Unique Values: \"1\"\n Name: \"gene_name\"\n Description: \"\"Official gene name/symbol assigned to the gene. Human gene name/symbol are approved by the HUGO Gene Nomenclature Committee (HGNC) and mouse gene name are approved by the Mouse Genome Informatics (MGI)\"\n Unique Values: \"17\"\n Name: \"disease_evidence_ECO:0000269\"\n Description: \"The PMID evidence for the association of the disease with the variant.\"\n Unique Values: \"1\"", "downloadurl": "/ln2data/releases/data/v-1.11.2/reviewed/rat_protein_enzyme_annotation_uniprotkb.csv" }