{ "bcoid": "GLY_000025", "title": "Human Glycohydrolases", "description": "The Human Glycohydrolases dataset contains a list of human [taxid:9606] glycohydrolases derived from ...", "filename": "human_protein_glycohydrolase.csv", "filetype": "csv", "categories": { "species": "Homo sapiens", "molecule": "Protein", "tags": "Glycohydrolases", "file_type": "csv", "status": "Reviewed", "scope": "internal" }, "minitable": { "content": [ [ "Q13231-1...", "Homo sapiens..." ], [ "P19961-1...", "Homo sapiens..." ] ], "headers": [ "uniprotkb_ca...", "species..." ], "colwidth": [ "40%", "20%" ] }, "sampledata": { "type": "table", "data": [ [ { "type": "string", "label": "uniprotkb_canonical_ac" }, { "type": "string", "label": "species" }, { "type": "string", "label": "status" }, { "type": "string", "label": "gene_symbol" }, { "type": "string", "label": "uniprotkb_protein_name" }, { "type": "string", "label": "ec_number" }, { "type": "string", "label": "brenda_ec_number" }, { "type": "string", "label": "cazy_gh_gamily" }, { "type": "string", "label": "interpro_id" }, { "type": "string", "label": "pfam_ac" }, { "type": "string", "label": "go_molecular_function" } ], [ "Q13231-1", "Homo sapiens (Human)", "reviewed", "CHIT1", "Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1)", "3.2.1.14", "", "GH18", "IPR002557|IPR036508|IPR011583|IPR029070|IPR001223|IPR001579|IPR017853", "PF01607|PF00704", "chitinase activity [GO:0004568]|chitin binding [GO:0008061]|endochitinase activity [GO:0008843]|hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" ], [ "P19961-1", "Homo sapiens (Human)", "reviewed", "AMY2B", "Alpha-amylase 2B (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase 2B) (Carcinoid alpha-amylase)", "3.2.1.1", "", "GH13", "IPR006048|IPR031319|IPR006046|IPR006047|IPR013780|IPR017853", "PF00128|PF02806", "alpha-amylase activity [GO:0004556]|alpha-amylase activity (releasing maltohexaose) [GO:0103025]|metal ion binding [GO:0046872]" ], [ "P54802-1", "Homo sapiens (Human)", "reviewed", "NAGLU", "Alpha-N-acetylglucosaminidase (EC 3.2.1.50) (N-acetyl-alpha-glucosaminidase) (NAG) [Cleaved into: Alpha-N-acetylglucosaminidase 82 kDa form; Alpha-N-acetylglucosaminidase 77 kDa form]", "3.2.1.50", "3.2.1.50", "GH89", "IPR017853|IPR029018|IPR007781|IPR024732|IPR024240|IPR024733", "PF05089|PF12972|PF12971", "alpha-N-acetylglucosaminidase activity [GO:0004561]" ], [ "P08236-1", "Homo sapiens (Human)", "reviewed", "GUSB", "Beta-glucuronidase (EC 3.2.1.31) (Beta-G1)", "3.2.1.31", "", "GH2", "IPR036156|IPR008979|IPR006101|IPR023232|IPR006103|IPR023230|IPR006102|IPR006104|IPR017853|IPR013783", "PF00703|PF02836|PF02837", "beta-glucuronidase activity [GO:0004566]|carbohydrate binding [GO:0030246]|protein domain specific binding [GO:0019904]|signaling receptor binding [GO:0005102]" ], [ "P04746-1", "Homo sapiens (Human)", "reviewed", "AMY2A", "Pancreatic alpha-amylase (PA) (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase)", "3.2.1.1", "3.2.1.1", "GH13", "IPR006048|IPR031319|IPR006046|IPR006047|IPR013780|IPR017853", "PF00128|PF02806", "alpha-amylase activity [GO:0004556]|alpha-amylase activity (releasing maltohexaose) [GO:0103025]|calcium ion binding [GO:0005509]|chloride ion binding [GO:0031404]" ], [ "P06280-1", "Homo sapiens (Human)", "reviewed", "GLA", "Alpha-galactosidase A (EC 3.2.1.22) (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Melibiase) (Agalsidase)", "3.2.1.22", "3.2.1.22", "GH27", "IPR013785|IPR002241|IPR000111|IPR013780|IPR017853|IPR035373", "PF16499|PF17450", "alpha-galactosidase activity [GO:0004557]|catalytic activity [GO:0003824]|galactoside binding [GO:0016936]|hydrolase activity [GO:0016787]|protein homodimerization activity [GO:0042803]|raffinose alpha-galactosidase activity [GO:0052692]|signaling receptor binding [GO:0005102]" ], [ "Q9BZQ6-1", "Homo sapiens (Human)", "reviewed", "EDEM3", "ER degradation-enhancing alpha-mannosidase-like protein 3 (EC 3.2.1.113) (Alpha-1,2-mannosidase EDEM3)", "3.2.1.113", "", "GH47", "IPR012341|IPR037322|IPR001382|IPR003137|IPR036026", "PF01532|PF02225", "calcium ion binding [GO:0005509]|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" ], [ "P16278-1", "Homo sapiens (Human)", "reviewed", "GLB1", "Beta-galactosidase (EC 3.2.1.23) (Acid beta-galactosidase) (Lactase) (Elastin receptor 1)", "3.2.1.23", "", "GH35", "IPR026283|IPR025300|IPR008979|IPR031330|IPR019801|IPR001944|IPR017853", "PF13364|PF01301", "beta-galactosidase activity [GO:0004565]|galactoside binding [GO:0016936]|protein homodimerization activity [GO:0042803]" ], [ "Q9BZP6-1", "Homo sapiens (Human)", "reviewed", "CHIA", "Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Lung-specific protein TSA1902)", "3.2.1.14", "3.2.1.14", "GH18", "IPR002557|IPR036508|IPR011583|IPR029070|IPR001223|IPR001579|IPR017853", "PF01607|PF00704", "chitinase activity [GO:0004568]|chitin binding [GO:0008061]|kinase binding [GO:0019900]" ], [ "Q9BTY2-1", "Homo sapiens (Human)", "reviewed", "FUCA2", "Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2)", "3.2.1.51", "3.2.1.51", "GH29", "IPR016286|IPR031919|IPR000933|IPR018526|IPR013780|IPR017853", "PF01120|PF16757", "alpha-L-fucosidase activity [GO:0004560]" ], [ "Q9UHN6-1", "Homo sapiens (Human)", "reviewed", "CEMIP2", "Cell surface hyaluronidase (EC 3.2.1.35) (Cell migration-inducing hyaluronidase 2) (Transmembrane protein 2)", "3.2.1.35", "", "", "IPR019316|IPR039477|IPR011050|IPR039473", "PF10162|PF15711", "cadherin binding [GO:0045296]|calcium ion binding [GO:0005509]|hyalurononglucosaminidase activity [GO:0004415]" ], [ "Q8WUJ3-1", "Homo sapiens (Human)", "reviewed", "CEMIP", "Cell migration-inducing and hyaluronan-binding protein (EC 3.2.1.35)", "3.2.1.35", "", "", "IPR019316|IPR039477|IPR011050|IPR039473|IPR025155", "PF10162|PF15711|PF13330", "clathrin heavy chain binding [GO:0032050]|ER retention sequence binding [GO:0046923]|hyaluronic acid binding [GO:0005540]|hyalurononglucosaminidase activity [GO:0004415]" ], [ "P54803-1", "Homo sapiens (Human)", "reviewed", "GALC", "Galactocerebrosidase (GALCERase) (EC 3.2.1.46) (Galactocerebroside beta-galactosidase) (Galactosylceramidase) (Galactosylceramide beta-galactosidase)", "3.2.1.46", "", "GH59", "IPR013785|IPR001286|IPR035394|IPR017853", "PF02057|PF17387", "galactosylceramidase activity [GO:0004336]" ], [ "P04066-1", "Homo sapiens (Human)", "reviewed", "FUCA1", "Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1)", "3.2.1.51", "3.2.1.51", "GH29", "IPR016286|IPR028755|IPR031919|IPR000933|IPR018526|IPR013780|IPR017853", "PF01120|PF16757", "alpha-L-fucosidase activity [GO:0004560]" ], [ "P35573-1", "Homo sapiens (Human)", "reviewed", "AGL", "Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)]", "2.4.1.25|3.2.1.33", "3.2.1.33", "GH133", "IPR008928|IPR010401|IPR032788|IPR029436|IPR032792|IPR032790|IPR006421|IPR017853", "PF06202|PF14701|PF14702|PF14699", "4-alpha-glucanotransferase activity [GO:0004134]|amylo-alpha-1,6-glucosidase activity [GO:0004135]|beta-maltose 4-alpha-glucanotransferase activity [GO:0102500]|glycogen debranching enzyme activity [GO:0004133]|polysaccharide binding [GO:0030247]|polyubiquitin modification-dependent protein binding [GO:0031593]" ], [ "P09848-1", "Homo sapiens (Human)", "reviewed", "LCT", "Lactase-phlorizin hydrolase (Lactase-glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Phlorizin hydrolase (EC 3.2.1.62)]", "3.2.1.108|3.2.1.62", "3.2.1.108|3.7.1.4", "GH1", "IPR001360|IPR018120|IPR033132|IPR017853", "PF00232", "beta-glucosidase activity [GO:0008422]|glycosylceramidase activity [GO:0017042]|lactase activity [GO:0000016]" ], [ "P10253-1", "Homo sapiens (Human)", "reviewed", "GAA", "Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) (Aglucosidase alfa) [Cleaved into: 76 kDa lysosomal alpha-glucosidase; 70 kDa lysosomal alpha-glucosidase]", "3.2.1.20", "3.2.1.20", "GH31", "IPR031727|IPR011013|IPR000322|IPR030458|IPR030459|IPR025887|IPR013780|IPR017853|IPR017957|IPR000519", "PF13802|PF01055|PF16863|PF00088", "alpha-1,4-glucosidase activity [GO:0004558]|carbohydrate binding [GO:0030246]|maltose alpha-glucosidase activity [GO:0032450]" ], [ "O60502-1", "Homo sapiens (Human)", "reviewed", "OGA", "Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT)", "3.2.1.169", "3.2.1.35", "GH84", "IPR016181|IPR011496|IPR017853", "PF07555", "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity [GO:0102571]|[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity [GO:0102167]|[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity [GO:0102166]|beta-N-acetylglucosaminidase activity [GO:0016231]|hyalurononglucosaminidase activity [GO:0004415]" ], [ "Q6NSJ0-1", "Homo sapiens (Human)", "reviewed", "MYORG", "Myogenesis-regulating glycosidase (EC 3.2.1.-) (Uncharacterized family 31 glucosidase KIAA1161)", "3.2.1.-", "", "GH31", "IPR000322|IPR017853", "PF01055", "hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" ], [ "Q8NFI3-1", "Homo sapiens (Human)", "reviewed", "ENGASE", "Cytosolic endo-beta-N-acetylglucosaminidase (ENGase) (EC 3.2.1.96)", "3.2.1.96", "3.2.1.96", "GH85", "IPR001357|IPR032979|IPR008979|IPR005201", "PF03644", "mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity [GO:0033925]" ], [ "P04062-1", "Homo sapiens (Human)", "reviewed", "GBA", "Lysosomal acid glucosylceramidase (Lysosomal acid GCase) (EC 3.2.1.45) (Acid beta-glucosidase) (Alglucerase) (Beta-glucocerebrosidase) (Beta-GC) (Cholesterol glucosyltransferase) (SGTase) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase) (EC 3.2.1.104) (D-glucosyl-N-acylsphingosine glucohydrolase) (Imiglucerase)", "3.2.1.45|2.4.1.-|3.2.1.104", "3.2.1.45", "GH30", "IPR033452|IPR001139|IPR033453|IPR013780|IPR017853", "PF02055|PF17189", "glucosylceramidase activity [GO:0004348]|glucosyltransferase activity [GO:0046527]|hydrolase activity [GO:0016787]|scavenger receptor binding [GO:0005124]|signaling receptor binding [GO:0005102]|steryl-beta-glucosidase activity [GO:0050295]" ], [ "Q12794-1", "Homo sapiens (Human)", "reviewed", "HYAL1", "Hyaluronidase-1 (Hyal-1) (EC 3.2.1.35) (Hyaluronoglucosaminidase-1) (Lung carcinoma protein 1) (LuCa-1)", "3.2.1.35", "3.2.1.35|4.2.2.1", "GH56", "IPR013785|IPR017853|IPR018155", "PF01630", "hyaluronan synthase activity [GO:0050501]|hyalurononglucosaminidase activity [GO:0004415]|transcription factor binding [GO:0008134]" ], [ "Q2M3T9-1", "Homo sapiens (Human)", "reviewed", "HYAL4", "Hyaluronidase-4 (Hyal-4) (EC 3.2.1.35) (Chondroitin sulfate endo-beta-N-acetylgalactosaminidase) (Chondroitin sulfate hydrolase) (CSHY) (Hyaluronoglucosaminidase-4)", "3.2.1.35", "3.2.1.35", "GH56", "IPR013785|IPR017853|IPR018155", "PF01630", "hyalurononglucosaminidase activity [GO:0004415]" ], [ "P38567-1", "Homo sapiens (Human)", "reviewed", "SPAM1", "Hyaluronidase PH-20 (Hyal-PH20) (EC 3.2.1.35) (Hyaluronoglucosaminidase PH-20) (Sperm adhesion molecule 1) (Sperm surface protein PH-20)", "3.2.1.35", "", "GH56", "IPR013785|IPR017853|IPR018155|IPR001439", "PF01630", "hyalurononglucosaminidase activity [GO:0004415]" ], [ "P35475-1", "Homo sapiens (Human)", "reviewed", "IDUA", "Alpha-L-iduronidase (EC 3.2.1.76)", "3.2.1.76", "3.2.1.76", "GH39", "IPR000514|IPR017853|IPR013783", "PF01229", "L-iduronidase activity [GO:0003940]|signaling receptor binding [GO:0005102]" ], [ "Q9Y251-1", "Homo sapiens (Human)", "reviewed", "HPSE", "Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit]", "3.2.1.166", "3.2.1.166", "GH79", "IPR005199|IPR017853", "PF03662", "beta-glucuronidase activity [GO:0004566]|heparanase activity [GO:0030305]|protein dimerization activity [GO:0046983]|syndecan binding [GO:0045545]" ], [ "Q12891-1", "Homo sapiens (Human)", "reviewed", "HYAL2", "Hyaluronidase-2 (Hyal-2) (EC 3.2.1.35) (Hyaluronoglucosaminidase-2) (Lung carcinoma protein 2) (LuCa-2)", "3.2.1.35", "3.2.1.35|4.2.2.1", "GH56", "IPR013785|IPR017853|IPR018155", "PF01630", "enzyme binding [GO:0019899]|hyaluronic acid binding [GO:0005540]|hyaluronoglucuronidase activity [GO:0033906]|hyalurononglucosaminidase activity [GO:0004415]|receptor signaling protein tyrosine kinase inhibitor activity [GO:0030294]|receptor tyrosine kinase binding [GO:0030971]|transcription coactivator activity [GO:0003713]|transforming growth factor beta binding [GO:0050431]|virus receptor activity [GO:0001618]" ], [ "O43820-1", "Homo sapiens (Human)", "reviewed", "HYAL3", "Hyaluronidase-3 (Hyal-3) (EC 3.2.1.35) (Hyaluronoglucosaminidase-3) (Lung carcinoma protein 3) (LuCa-3)", "3.2.1.35", "3.2.1.35", "GH56", "IPR013785|IPR017853|IPR018155|IPR027260", "PF01630", "hyaluronoglucuronidase activity [GO:0033906]|hyalurononglucosaminidase activity [GO:0004415]" ], [ "Q14697-1", "Homo sapiens (Human)", "reviewed", "GANAB", "Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha)", "3.2.1.207", "3.2.1.84", "GH31", "IPR011013|IPR000322|IPR030458|IPR030459|IPR025887|IPR013780|IPR017853", "PF13802|PF01055", "alpha-glucosidase activity [GO:0090599]|carbohydrate binding [GO:0030246]|glucan 1,3-alpha-glucosidase activity [GO:0033919]|RNA binding [GO:0003723]" ], [ "Q8WVB3-1", "Homo sapiens (Human)", "reviewed", "HEXD", "Hexosaminidase D (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase D) (Hexosaminidase domain-containing protein) (N-acetyl-beta-galactosaminidase)", "3.2.1.52", "", "GH20", "IPR015883|IPR017853|IPR038901", "PF00728", "beta-N-acetylhexosaminidase activity [GO:0004563]|hexosaminidase activity [GO:0015929]|N-acetyl-beta-D-galactosaminidase activity [GO:0102148]" ], [ "P17050-1", "Homo sapiens (Human)", "reviewed", "NAGA", "Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B)", "3.2.1.49", "3.2.1.49", "GH27", "IPR013785|IPR002241|IPR000111|IPR013780|IPR017853|IPR035373", "PF16499|PF17450", "alpha-galactosidase activity [GO:0004557]|alpha-N-acetylgalactosaminidase activity [GO:0008456]|protein homodimerization activity [GO:0042803]" ], [ "Q8N1E2-1", "Homo sapiens (Human)", "reviewed", "LYG1", "Lysozyme g-like protein 1 (EC 3.2.1.-)", "3.2.1.-", "", "GH23", "IPR002152|IPR023346", "#VALUE!", "lysozyme activity [GO:0003796]" ], [ "Q99519-1", "Homo sapiens (Human)", "reviewed", "NEU1", "Sialidase-1 (EC 3.2.1.18) (Acetylneuraminyl hydrolase) (G9 sialidase) (Lysosomal sialidase) (N-acetyl-alpha-neuraminidase 1)", "3.2.1.18", "3.2.1.18", "GH33", "IPR011040|IPR026856|IPR036278", "PF13088", "alpha-sialidase activity [GO:0016997]|exo-alpha-(2->3)-sialidase activity [GO:0052794]|exo-alpha-(2->6)-sialidase activity [GO:0052795]|exo-alpha-(2->8)-sialidase activity [GO:0052796]|exo-alpha-sialidase activity [GO:0004308]" ], [ "Q8WWR8-1", "Homo sapiens (Human)", "reviewed", "NEU4", "Sialidase-4 (EC 3.2.1.18) (N-acetyl-alpha-neuraminidase 4)", "3.2.1.18", "3.2.1.18", "GH33", "IPR011040|IPR026946|IPR026856|IPR036278", "PF13088", "exo-alpha-(2->3)-sialidase activity [GO:0052794]|exo-alpha-(2->6)-sialidase activity [GO:0052795]|exo-alpha-(2->8)-sialidase activity [GO:0052796]|exo-alpha-sialidase activity [GO:0004308]" ], [ "Q9Y3R4-1", "Homo sapiens (Human)", "reviewed", "NEU2", "Sialidase-2 (EC 3.2.1.18) (Cytosolic sialidase) (N-acetyl-alpha-neuraminidase 2)", "3.2.1.18", "3.2.1.18", "GH33", "IPR011040|IPR026945|IPR026856|IPR036278", "PF13088", "exo-alpha-(2->3)-sialidase activity [GO:0052794]|exo-alpha-(2->6)-sialidase activity [GO:0052795]|exo-alpha-(2->8)-sialidase activity [GO:0052796]|exo-alpha-sialidase activity [GO:0004308]" ], [ "Q32M88-1", "Homo sapiens (Human)", "reviewed", "PGGHG", "Protein-glucosylgalactosylhydroxylysine glucosidase (EC 3.2.1.107) (Acid trehalase-like protein 1)", "3.2.1.107", "", "GH65", "IPR008928|IPR012341|IPR005195", "PF03632", "hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]|protein-glucosylgalactosylhydroxylysine glucosidase activity [GO:0047402]" ], [ "Q9UQ49-1", "Homo sapiens (Human)", "reviewed", "NEU3", "Sialidase-3 (EC 3.2.1.18) (Ganglioside sialidase) (Membrane sialidase) (N-acetyl-alpha-neuraminidase 3)", "3.2.1.18", "3.2.1.18", "GH33", "IPR011040|IPR026944|IPR026856|IPR036278", "PF13088", "alpha-sialidase activity [GO:0016997]|exo-alpha-(2->3)-sialidase activity [GO:0052794]|exo-alpha-(2->6)-sialidase activity [GO:0052795]|exo-alpha-(2->8)-sialidase activity [GO:0052796]|exo-alpha-sialidase activity [GO:0004308]" ], [ "P14410-1", "Homo sapiens (Human)", "reviewed", "SI", "Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]", "3.2.1.48|3.2.1.10", "3.2.1.10|3.2.1.48", "GH31", "IPR031727|IPR011013|IPR000322|IPR030458|IPR030459|IPR013780|IPR017853|IPR017957|IPR000519", "PF01055|PF16863|PF00088", "carbohydrate binding [GO:0030246]|oligo-1,6-glucosidase activity [GO:0004574]|sucrose alpha-glucosidase activity [GO:0004575]" ], [ "O43280-1", "Homo sapiens (Human)", "reviewed", "TREH", "Trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase)", "3.2.1.28", "", "GH37", "IPR008928|IPR012341|IPR001661|IPR018232", "PF01204", "alpha,alpha-trehalase activity [GO:0004555]" ], [ "Q13724-1", "Homo sapiens (Human)", "reviewed", "MOGS", "Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Processing A-glucosidase I)", "3.2.1.106", "", "GH63", "IPR008928|IPR012341|IPR031335|IPR031631|IPR038518|IPR004888", "PF03200|PF16923", "glucosidase activity [GO:0015926]|mannosyl-oligosaccharide glucosidase activity [GO:0004573]" ], [ "Q5SRI9-1", "Homo sapiens (Human)", "reviewed", "MANEA", "Glycoprotein endo-alpha-1,2-mannosidase (Endo-alpha mannosidase) (Endomannosidase) (hEndo) (EC 3.2.1.130) (Mandaselin)", "3.2.1.130", "3.2.1.130", "GH99", "IPR026071|IPR017853", "PF16317", "alpha-mannosidase activity [GO:0004559]|glycoprotein endo-alpha-1,2-mannosidase activity [GO:0004569]" ], [ "P61626-1", "Homo sapiens (Human)", "reviewed", "LYZ", "Lysozyme C (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C)", "3.2.1.17", "3.2.1.17", "GH22", "IPR001916|IPR019799|IPR000974|IPR023346|IPR030056", "PF00062", "identical protein binding [GO:0042802]|lysozyme activity [GO:0003796]" ], [ "Q9UKM7-1", "Homo sapiens (Human)", "reviewed", "MAN1B1", "Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (ER mannosidase 1) (ERMan1) (Man9GlcNAc2-specific-processing alpha-mannosidase) (Mannosidase alpha class 1B member 1)", "3.2.1.113", "3.2.1.113", "GH47", "IPR012341|IPR001382|IPR036026", "PF01532", "calcium ion binding [GO:0005509]|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" ], [ "Q16706-1", "Homo sapiens (Human)", "reviewed", "MAN2A1", "Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)", "3.2.1.114", "", "GH38", "IPR011013|IPR011330|IPR011682|IPR015341|IPR037094|IPR000602|IPR027291|IPR028995|IPR013780", "PF09261|PF07748|PF01074", "alpha-mannosidase activity [GO:0004559]|carbohydrate binding [GO:0030246]|hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799]|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity [GO:0004572]|metal ion binding [GO:0046872]" ], [ "Q96QH8-1", "Homo sapiens (Human)", "reviewed", "SPACA5; SPACA5B", "Sperm acrosome-associated protein 5 (EC 3.2.1.17) (Lysozyme-like protein 5) (Sperm-specific lysozyme-like protein X) (SLLP-X)", "3.2.1.17", "", "GH22", "IPR001916|IPR000974|IPR023346|IPR030064", "PF00062", "lysozyme activity [GO:0003796]" ], [ "Q9UEF7-1", "Homo sapiens (Human)", "reviewed", "KL", "Klotho (EC 3.2.1.31) [Cleaved into: Klotho peptide]", "3.2.1.31", "", "GH1", "IPR001360|IPR033132|IPR017853|IPR028546", "PF00232", "beta-glucosidase activity [GO:0008422]|beta-glucuronidase activity [GO:0004566]|fibroblast growth factor binding [GO:0017134]|fibroblast growth factor receptor binding [GO:0005104]|hormone activity [GO:0005179]|vitamin D binding [GO:0005499]" ], [ "P06865-1", "Homo sapiens (Human)", "reviewed", "HEXA", "Beta-hexosaminidase subunit alpha (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit alpha) (Hexosaminidase subunit A) (N-acetyl-beta-glucosaminidase subunit alpha)", "3.2.1.52", "3.2.1.169", "GH20", "IPR025705|IPR015883|IPR017853|IPR029018|IPR029019", "PF00728|PF14845", "acetylglucosaminyltransferase activity [GO:0008375]|beta-N-acetylhexosaminidase activity [GO:0004563]|N-acetyl-beta-D-galactosaminidase activity [GO:0102148]|protein heterodimerization activity [GO:0046982]" ], [ "P07686-1", "Homo sapiens (Human)", "reviewed", "HEXB", "Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A]", "3.2.1.52", "3.2.1.52", "GH20", "IPR025705|IPR015883|IPR017853|IPR029018|IPR029019", "PF00728|PF14845", "acetylglucosaminyltransferase activity [GO:0008375]|beta-N-acetylhexosaminidase activity [GO:0004563]|N-acetyl-beta-D-galactosaminidase activity [GO:0102148]|protein heterodimerization activity [GO:0046982]|protein homodimerization activity [GO:0042803]" ], [ "Q8TET4-1", "Homo sapiens (Human)", "reviewed", "GANC", "Neutral alpha-glucosidase C (EC 3.2.1.20)", "3.2.1.20", "", "GH31", "IPR011013|IPR000322|IPR030458|IPR025887|IPR013780|IPR017853", "PF13802|PF01055", "alpha-1,4-glucosidase activity [GO:0004558]|carbohydrate binding [GO:0030246]|maltose alpha-glucosidase activity [GO:0032450]" ], [ "Q8IW92-1", "Homo sapiens (Human)", "reviewed", "GLB1L2", "Beta-galactosidase-1-like protein 2 (EC 3.2.1.-)", "3.2.1.-", "", "GH35", "IPR026283|IPR008979|IPR031330|IPR019801|IPR001944|IPR017853", "PF01301", "beta-galactosidase activity [GO:0004565]" ], [ "Q8NCI6-1", "Homo sapiens (Human)", "reviewed", "GLB1L3", "Beta-galactosidase-1-like protein 3 (EC 3.2.1.-)", "3.2.1.-", "", "GH35", "IPR026283|IPR008979|IPR031330|IPR001944|IPR017853", "PF01301", "beta-galactosidase activity [GO:0004565]" ], [ "Q2M2H8-1", "Homo sapiens (Human)", "reviewed", "MGAM2", "Probable maltase-glucoamylase 2 (Maltase-glucoamylase (alpha-glucosidase) pseudogene) [Includes: Glucoamylase (EC 3.2.1.3) (Glucan 1,4-alpha-glucosidase)]", "3.2.1.3", "", "GH31", "IPR031727|IPR011013|IPR000322|IPR030458|IPR013780|IPR017853|IPR000519", "PF01055|PF16863|PF00088", "carbohydrate binding [GO:0030246]|glucan 1,4-alpha-glucosidase activity [GO:0004339]" ], [ "O43451-1", "Homo sapiens (Human)", "reviewed", "MGAM", "Maltase-glucoamylase, intestinal [Includes: Maltase (EC 3.2.1.20) (Alpha-glucosidase); Glucoamylase (EC 3.2.1.3) (Glucan 1,4-alpha-glucosidase)]", "3.2.1.20|3.2.1.3", "3.2.1.20|3.2.1.3", "GH31", "IPR031727|IPR011013|IPR000322|IPR030458|IPR030459|IPR013780|IPR017853|IPR017957|IPR000519", "PF01055|PF16863|PF00088", "alpha-1,4-glucosidase activity [GO:0004558]|amylase activity [GO:0016160]|carbohydrate binding [GO:0030246]|catalytic activity [GO:0003824]|glucan 1,4-alpha-glucosidase activity [GO:0004339]|maltose alpha-glucosidase activity [GO:0032450]" ], [ "P49641-3", "Homo sapiens (Human)", "reviewed", "MAN2A2", "Alpha-mannosidase 2x (EC 3.2.1.114) (Alpha-mannosidase IIx) (Man IIx) (Mannosidase alpha class 2A member 2) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)", "3.2.1.114", "", "GH38", "IPR011013|IPR011330|IPR011682|IPR015341|IPR037094|IPR000602|IPR027291|IPR028995|IPR013780", "PF09261|PF07748|PF01074", "alpha-mannosidase activity [GO:0004559]|carbohydrate binding [GO:0030246]|hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799]|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity [GO:0004572]|metal ion binding [GO:0046872]" ], [ "P33908-1", "Homo sapiens (Human)", "reviewed", "MAN1A1", "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Man(9)-alpha-mannosidase) (Man9-mannosidase) (Mannosidase alpha class 1A member 1) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA)", "3.2.1.113", "", "GH47", "IPR012341|IPR001382|IPR036026", "PF01532", "calcium ion binding [GO:0005509]|mannosidase activity [GO:0015923]|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" ], [ "Q7Z4W2-1", "Homo sapiens (Human)", "reviewed", "LYZL2", "Lysozyme-like protein 2 (Lysozyme-2) (EC 3.2.1.17)", "3.2.1.17", "", "GH22", "IPR001916|IPR019799|IPR000974|IPR023346|IPR030057", "PF00062", "lysozyme activity [GO:0003796]" ], [ "Q9NR34-1", "Homo sapiens (Human)", "reviewed", "MAN1C1", "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (HMIC) (Mannosidase alpha class 1C member 1) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC)", "3.2.1.113", "3.2.1.113", "GH47", "IPR012341|IPR001382|IPR036026", "PF01532", "calcium ion binding [GO:0005509]|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" ], [ "O00462-1", "Homo sapiens (Human)", "reviewed", "MANBA", "Beta-mannosidase (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase)", "3.2.1.25", "", "GH2", "IPR036156|IPR041625|IPR008979|IPR006103|IPR017853|IPR013783|IPR041447", "PF02836|PF17753|PF17786", "beta-mannosidase activity [GO:0004567]|mannose binding [GO:0005537]" ], [ "O00754-1", "Homo sapiens (Human)", "reviewed", "MAN2B1", "Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) [Cleaved into: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha-mannosidase E peptide]", "3.2.1.24", "3.2.1.24", "GH38", "IPR011013|IPR041147|IPR011330|IPR011682|IPR015341|IPR037094|IPR000602|IPR027291|IPR028995|IPR013780", "PF09261|PF17677|PF07748|PF01074", "alpha-mannosidase activity [GO:0004559]|carbohydrate binding [GO:0030246]|metal ion binding [GO:0046872]" ], [ "Q5VSG8-1", "Homo sapiens (Human)", "reviewed", "MANEAL", "Glycoprotein endo-alpha-1,2-mannosidase-like protein (EC 3.2.1.-)", "3.2.1.-", "", "GH99", "IPR026071", "PF16317", "alpha-mannosidase activity [GO:0004559]" ], [ "Q9HCG7-1", "Homo sapiens (Human)", "reviewed", "GBA2", "Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) (Beta-glucocerebrosidase 2) (Beta-glucosidase 2) (Bile acid beta-glucosidase GBA2) (Bile acid glucosyl transferase GBA2) (Cholesterol glucosyltransferase GBA2) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase GBA2) (EC 3.2.1.104) (Glucosylceramidase 2)", "3.2.1.45|2.4.1.-|3.2.1.104", "3.2.1.45", "GH116", "IPR008928|IPR012341|IPR014551|IPR006775|IPR024462", "PF04685|PF12215", "beta-glucosidase activity [GO:0008422]|glucosylceramidase activity [GO:0004348]|glucosyltransferase activity [GO:0046527]|steryl-beta-glucosidase activity [GO:0050295]" ], [ "Q9H227-1", "Homo sapiens (Human)", "reviewed", "GBA3", "Cytosolic beta-glucosidase (EC 3.2.1.21) (Cytosolic beta-glucosidase-like protein 1) (Cytosolic glycosylceramidase) (Cytosolic GCase) (Glucosidase beta acid 3) (Glucosylceramidase beta 3) (Klotho-related protein) (KLrP)", "3.2.1.21", "3.2.1.21", "GH1", "IPR001360|IPR033132|IPR017853", "PF00232", "beta-galactosidase activity [GO:0004565]|beta-glucosidase activity [GO:0008422]|galactosylceramidase activity [GO:0004336]|glucosylceramidase activity [GO:0004348]|glycosylceramidase activity [GO:0017042]|scopolin beta-glucosidase activity [GO:0102483]" ], [ "Q6UWU2-1", "Homo sapiens (Human)", "reviewed", "GLB1L", "Beta-galactosidase-1-like protein (EC 3.2.1.-)", "3.2.1.-", "", "GH35", "IPR026283|IPR008979|IPR031330|IPR001944|IPR017853", "PF01301", "beta-galactosidase activity [GO:0004565]" ], [ "Q86SG7-1", "Homo sapiens (Human)", "reviewed", "LYG2", "Lysozyme g-like protein 2 (EC 3.2.1.-)", "3.2.1.-", "3.2.1.17", "GH23", "IPR002152|IPR023346", "", "lysozyme activity [GO:0003796]" ], [ "O75951-1", "Homo sapiens (Human)", "reviewed", "LYZL6", "Lysozyme-like protein 6 (EC 3.2.1.17)", "3.2.1.17", "", "GH22", "IPR001916|IPR019799|IPR000974|IPR023346|IPR030063", "PF00062", "lysozyme activity [GO:0003796]" ], [ "Q9Y2E5-1", "Homo sapiens (Human)", "reviewed", "MAN2B2", "Epididymis-specific alpha-mannosidase (EC 3.2.1.24) (Mannosidase alpha class 2B member 2)", "3.2.1.24", "", "GH38", "IPR011013|IPR041147|IPR011330|IPR011682|IPR015341|IPR037094|IPR000602|IPR027291|IPR028995|IPR013780", "PF09261|PF17677|PF07748|PF01074", "alpha-mannosidase activity [GO:0004559]|carbohydrate binding [GO:0030246]|metal ion binding [GO:0046872]" ], [ "Q9NTJ4-1", "Homo sapiens (Human)", "reviewed", "MAN2C1", "Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha mannosidase 6A8B) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1)", "3.2.1.24", "3.2.1.24", "GH38", "IPR011013|IPR041147|IPR011330|IPR011682|IPR015341|IPR037094|IPR000602|IPR027291|IPR028995", "PF09261|PF17677|PF07748|PF01074", "alpha-mannosidase activity [GO:0004559]|carbohydrate binding [GO:0030246]|metal ion binding [GO:0046872]" ], [ "O60476-1", "Homo sapiens (Human)", "reviewed", "MAN1A2", "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (EC 3.2.1.113) (Mannosidase alpha class 1A member 2) (Processing alpha-1,2-mannosidase IB) (Alpha-1,2-mannosidase IB)", "3.2.1.113", "3.2.1.113", "GH47", "IPR012341|IPR001382|IPR036026", "PF01532", "calcium ion binding [GO:0005509]|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" ], [ "Q6UWQ5-1", "Homo sapiens (Human)", "reviewed", "LYZL1", "Lysozyme-like protein 1 (EC 3.2.1.17)", "3.2.1.17", "", "GH22", "IPR001916|IPR019799|IPR000974|IPR023346|IPR030057", "PF00062", "lysozyme activity [GO:0003796]" ], [ "Q01459-1", "Homo sapiens (Human)", "reviewed", "CTBS", "Di-N-acetylchitobiase (EC 3.2.1.-)", "3.2.1.-", "", "GH18", "IPR011583|IPR029070|IPR001223|IPR001579|IPR017853", "PF00704", "chitinase activity [GO:0004568]|chitin binding [GO:0008061]" ], [ "P08195-1", "Homo sapiens (Human)", "reviewed", "SLC3A2", "4F2 cell-surface antigen heavy chain (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98)", "", "", "GH13", "IPR006047|IPR013780|IPR017853|IPR042280|IPR031984", "PF00128|PF16028", "cadherin binding [GO:0045296]|calcium:sodium antiporter activity [GO:0005432]|catalytic activity [GO:0003824]|double-stranded RNA binding [GO:0003725]|neutral amino acid transmembrane transporter activity [GO:0015175]|RNA binding [GO:0003723]" ], [ "P36222-1", "Homo sapiens (Human)", "reviewed", "CHI3L1", "Chitinase-3-like protein 1 (39 kDa synovial protein) (Cartilage glycoprotein 39) (CGP-39) (GP-39) (hCGP-39) (YKL-40)", "", "", "GH18", "IPR028538|IPR011583|IPR029070|IPR001223|IPR017853", "PF00704", "carbohydrate binding [GO:0030246]|chitin binding [GO:0008061]|extracellular matrix structural constituent [GO:0005201]" ], [ "Q86Z14-1", "Homo sapiens (Human)", "reviewed", "KLB", "Beta-klotho (BKL) (BetaKlotho) (Klotho beta-like protein)", "", "", "GH1", "IPR001360|IPR017853", "PF00232", "fibroblast growth factor binding [GO:0017134]|fibroblast growth factor receptor binding [GO:0005104]|hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" ], [ "Q9BWS9-1", "Homo sapiens (Human)", "reviewed", "CHID1", "Chitinase domain-containing protein 1 (Stabilin-1-interacting chitinase-like protein) (SI-CLP)", "", "", "", "IPR011583|IPR029070|IPR001223|IPR017853", "PF00704", "chitin binding [GO:0008061]|oligosaccharide binding [GO:0070492]" ], [ "Q15782-4", "Homo sapiens (Human)", "reviewed", "CHI3L2", "Chitinase-3-like protein 2 (Chondrocyte protein 39) (YKL-39)", "", "", "GH18", "IPR028541|IPR011583|IPR029070|IPR001223|IPR017853", "PF00704", "carbohydrate binding [GO:0030246]|chitin binding [GO:0008061]|hydrolase activity [GO:0016787]" ], [ "Q92611-1", "Homo sapiens (Human)", "reviewed", "EDEM1", "ER degradation-enhancing alpha-mannosidase-like protein 1", "", "", "GH47", "IPR012341|IPR001382|IPR036026", "PF01532", "calcium ion binding [GO:0005509]|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]|misfolded protein binding [GO:0051787]" ], [ "Q9BV94-1", "Homo sapiens (Human)", "reviewed", "EDEM2", "ER degradation-enhancing alpha-mannosidase-like protein 2", "", "", "GH47", "IPR012341|IPR001382|IPR036026", "PF01532", "calcium ion binding [GO:0005509]|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" ], [ "Q8WWQ2-1", "Homo sapiens (Human)", "reviewed", "HPSE2", "Inactive heparanase-2 (Hpa2)", "", "", "", "IPR005199|IPR017853", "PF03662", "heparanase activity [GO:0030305]|heparan sulfate proteoglycan binding [GO:0043395]" ], [ "Q6UWM7-1", "Homo sapiens (Human)", "reviewed", "LCTL", "Lactase-like protein (Klotho/lactase-phlorizin hydrolase-related protein)", "", "", "GH1", "IPR001360|IPR018120|IPR033132|IPR017853", "PF00232", "beta-glucosidase activity [GO:0008422]" ], [ "Q12889-1", "Homo sapiens (Human)", "reviewed", "OVGP1", "Oviduct-specific glycoprotein (Estrogen-dependent oviduct protein) (Mucin-9) (Oviductal glycoprotein) (Oviductin)", "", "", "GH18", "IPR011583|IPR029070|IPR001223|IPR017853", "PF00704", "chitinase activity [GO:0004568]|chitin binding [GO:0008061]" ], [ "Q96KX0-1", "Homo sapiens (Human)", "reviewed", "LYZL4", "Lysozyme-like protein 4 (Lysozyme-4)", "", "", "GH22", "IPR001916|IPR019799|IPR000974|IPR023346|IPR030062", "PF00062", "lysozyme activity [GO:0003796]" ], [ "Q68DE3-1", "Homo sapiens (Human)", "reviewed", "USF3", "Basic helix-loop-helix domain-containing protein USF3 (Upstream transcription factor 3)", "", "", "GH47", "IPR011598|IPR036638", "PF00010", "DNA binding [GO:0003677]|DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]|protein dimerization activity [GO:0046983]" ], [ "Q04446-1", "Homo sapiens (Human)", "reviewed", "GBE1", "1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) (Brancher enzyme) (Glycogen-branching enzyme)", "2.4.1.18", "", "GH13", "IPR006048|IPR037439|IPR006047|IPR004193|IPR013780|IPR017853|IPR013783|IPR014756", "PF00128|PF02806|PF02922", "1,4-alpha-glucan branching enzyme activity [GO:0003844]|1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) [GO:0102752]|cation binding [GO:0043169]|hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" ] ] }, "readme": "Name\n - Human Glycohydrolases\n\nVersion\n - 1.11.2\n\nCreated on\n - 2019-01-23T17:21:05.892318\n\nModified on\n - 2020-04-10T11:26:26.178942\n\nCreated by\n - Jeet Vora [jeetvora@gwu.edu], Rahi Navelkar [rsn13@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Xavier Holmes [xavierh@email.gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Amanda Bell [amandab2140@gwu.edu], Jonathon Keeney [keeneyjg@gwu.edu], Millicent Quartey [mquartey@email.gwu.edu]\n\nAuthors\n - Jeet Vora [jeetvora@gwu.edu]\n\nChecksum\n - \n\nUsability Domain\n - The Human Glycohydrolases dataset contains a list of human [taxid:9606] glycohydrolases derived from UniProtKB database using advanced search and other databases including CAZy, InterPro and Pfam. . If you use this dataset please provide proper attribution to UniProtKB and GlyGen\n\nDescription Domain\n Keywords\n - glycohydrolase\n - glycosidase\n - EC Number\n - CAZy\n\n Pipeline Steps\n - Step-1: The script maps and replaces the UniProtKb accession to the UniProtKB canonical accession\n\nExecution Domain\n Scripts - https://github.com/GW-HIVE/glygen-backend-integration/blob/master/pipeline/integrator/make-protein-dataset.py\n\n\n Software Prerequisites\n Name: Python\n Version: 2.7.5\n URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n Input Subdomain\n Name: human_protein_glycohydrolase.csv\n URI: https://data.glygen.org/ln2data/releases/data/v-1.11.2/compiled/human_protein_glycohydrolase.csv\n Name: human_protein_masterlist.csv\n URI: https://data.glygen.org/ln2data/releases/data/v-1.11.2/reviewed/human_protein_masterlist.csv\n Output Subdomain\n Name: human_protein_glycohydrolase.csv\n URI: https://data.glygen.org/ln2data/releases/data/v-1.11.2/reviewed/human_protein_glycohydrolase.csv\n Name: human_protein_glycohydrolase.stat.csv\n URI: https://data.glygen.org/ln2data/releases/data/v-1.11.2/reviewed/human_protein_glycohydrolase.stat.csv\n\nFields\n Name: \"uniprotkb_canonical_ac\"\n Description: \"\"\n Unique Values: \"16\"\n Name: \"motif_start\"\n Description: \"\"\n Unique Values: \"23\"\n Name: \"filter_flags\"\n Description: \"Filter tags/flags assigned to the mutation entries that have passed the mutation filter criteria\"\n Unique Values: \"19\"\n Name: \"sift_prediction\"\n Description: \"The SIFT qualitative prediction is derived from this score such that substitutions with a score < 0.05 are called 'deleterious' and all others are called 'tolerated\"\n Unique Values: \"3\"\n Name: \"somatic_status\"\n Description: \"The status of the variant whether it is germline (somatic status =0) or somatic (somatic status =1) variant\"\n Unique Values: \"1\"\n Name: \"chr_pos\"\n Description: \"Chromosome Position of a gene\"\n Unique Values: \"19\"\n Name: \"chr_id\"\n Description: \"\"\n Unique Values: \"10\"\n Name: \"dbsnp_id\"\n Description: \"\"A reference SNP ID number\"\n Unique Values: \"19\"\n Name: \"evidence_ECO:0000313\"\n Description: \"A type of evidence that is imported information used in an automatic assertion\"\n Unique Values: \"1\"\n Name: \"xref_id\"\n Description: \"ID of the X-ref\"\n Unique Values: \"19\"\n Name: \"mim_id\"\n Description: \"Disease ID from the OMIM database\"\n Unique Values: \"1\"\n Name: \"description\"\n Description: \"\"\n Unique Values: \"1\"\n Name: \"begin_aa_pos\"\n Description: \"Start position of the amino acid in the sequence of a protein in UniProtKB\"\n Unique Values: \"18\"\n Name: \"cytogenic_band\"\n Description: \"One of the subregions of a chromosome visible microscopically after special staining\"\n Unique Values: \"14\"\n Name: \"aa_pos\"\n Description: \"Position of the amino acid in canonical sequence of protein in the UniProtKB database\"\n Unique Values: \"18\"\n Name: \"ref_aa\"\n Description: \"Reference amino acid residue\"\n Unique Values: \"9\"\n Name: \"sift_score\"\n Description: \"SIFT predicts whether an amino acid substitution is likely to affect protein function based on sequence homology and the physico-chemical similarity between the alternate amino acids. The data we provide for each amino acid substitution is a score and a qualitative prediction (either 'tolerated' or 'deleterious'). The score is the normalized probability that the amino acid change is tolerated so scores nearer zero are more likely to be deleterious. The qualitative prediction is derived from this score such that substitutions with a score < 0.05 are called 'deleterious' and all others are called 'tolerated\"\n Unique Values: \"10\"\n Name: \"alt_motif\"\n Description: \"Altered motif\"\n Unique Values: \"24\"\n Name: \"disease_xrefs\"\n Description: \"\"\n Unique Values: \"1\"\n Name: \"polyphen_score\"\n Description: \"The score assigned to a amino acid substitution by a tool called as PolyPhen (=Polymorphism Phenotyping) which predicts possible impact of an amino acid substitution on the structure and function of a human protein using straightforward physical and comparative considerations. The PolyPhen score ranges from 0.0 (tolerated) to 1.0 (deleterious). Variants with scores of 0.0 are predicted to be benign. Values closer to 1.0 are more confidently predicted to be deleterious\"\n Unique Values: \"1\"\n Name: \"polyphen_prediction\"\n Description: \"\"The PolyPhen prediction values are - greater than 0.908 - \"\"Probably Damaging\"\"; greater than 0.446 and less than or equal to 0.908 - \"\"Possibly Damaging\"\"; less than or equal to 0.446 - \"\"Benign\"\"\"\n Unique Values: \"1\"\n Name: \"is_known_glycoprotein\"\n Description: \"Yes or no flag to denote if a protein is experimentally proven glycoprotein\"\n Unique Values: \"1\"\n Name: \"alt_nt\"\n Description: \"Alternative nucleotide\"\n Unique Values: \"1\"\n Name: \"protein_name\"\n Description: \"Protein name in the UniProtKB\"\n Unique Values: \"16\"\n Name: \"disease_evidence_ECO:0000313\"\n Description: \"The evidence that could be a PMID or a ClinVar ID that associates disease with the variant\"\n Unique Values: \"1\"\n Name: \"effect\"\n Description: \"The effect on glycosylation or N-sequon due to variation at site of glycosylated amino acid.\"\n Unique Values: \"3\"\n Name: \"end_aa_pos\"\n Description: \"End position of the amino acid in the sequence of a protein in UniProtKB\"\n Unique Values: \"18\"\n Name: \"mutation_type\"\n Description: \"Denotes whether mutation was reported with reference to amino acid or nucleotide\"\n Unique Values: \"1\"\n Name: \"disease_description\"\n Description: \"The disease description and/or definition \"\n Unique Values: \"1\"\n Name: \"do_id\"\n Description: \"Disease Ontology identifier\"\n Unique Values: \"1\"\n Name: \"evidence_ECO:0000269\"\n Description: \"A type of experimental evidence that is used in a manual assertion. Usually the values are PMIDs\"\n Unique Values: \"1\"\n Name: \"ref_nt\"\n Description: \"Reference nucleotide\"\n Unique Values: \"4\"\n Name: \"disease\"\n Description: \"The disease name for the cell line\"\n Unique Values: \"1\"\n Name: \"alt_aa\"\n Description: \"Altered amino acid residue\"\n Unique Values: \"10\"\n Name: \"cosmic_id\"\n Description: \"Legacy mutation identifier (COSM) in Catalogue of Somatic Mutations in Cancer (COSMIC) represents existing COSM mutation identifiers. This identifier remains the same between different assemblies (GRCh37 and GRCh38). All the COSM ids at the same genomic location have been collapsed into one representative COSM id. These ids are maintained to help track existing mutations\"\n Unique Values: \"1\"\n Name: \"ref_motif\"\n Description: \"Reference motif\"\n Unique Values: \"20\"\n Name: \"xref_key\"\n Description: \"Source key associated to the xref_id\"\n Unique Values: \"2\"\n Name: \"minor_allelic_frequency\"\n Description: \"\"\n Unique Values: \"1\"\n Name: \"gene_name\"\n Description: \"\"Official gene name/symbol assigned to the gene. Human gene name/symbol are approved by the HUGO Gene Nomenclature Committee (HGNC) and mouse gene name are approved by the Mouse Genome Informatics (MGI)\"\n Unique Values: \"17\"\n Name: \"disease_evidence_ECO:0000269\"\n Description: \"The PMID evidence for the association of the disease with the variant.\"\n Unique Values: \"1\"", "downloadurl": "/ln2data/releases/data/v-1.11.2/reviewed/human_protein_glycohydrolase.csv" }