{
    "uniprot_canonical_ac": "A2ATD1-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A2ATD1-1|ISM1_MOUSE Isoform 1 of Isthmin-1  OS=Mus musculus OX=10090 GN=Ism1 PE=1 SV=1 CANONICAL=A2ATD1-1", 
        "length": 454, 
        "sequence": "MVRLAAELLLLLGLLLLTLHITVLRGSGASDRQDAAAGNNNLNLESDSTSETSFPLSKEAPEEHQVVHQPFPRQRFPPETGHPSLQRDGPRSFLLDLPNFPDLSKADINGQNPNIQVTIEVVDGPDSEAEKDQHPENKPSWSLPAPDWRAWWQRSLSLARTNSGDQDDKYDSTSDDSNFLSVPRGWDRPAPGHRTFETKEQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACIATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDMDSCERWMSCKSEFLKKYMHKVINDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY"
    }, 
    "uniprot_id": "ISM1_MOUSE", 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2ATD1", 
                    "id": "A2ATD1", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "reaction_enzymes": [], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/12128218", 
                    "type": "PubMed", 
                    "id": "12128218"
                }
            ], 
            "title": "Isthmin is a novel secreted protein expressed as part of the Fgf-8 synexpression group in the Xenopus midbrain-hindbrain organizer.", 
            "journal": "Mech. Dev.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2ATD1", 
                    "id": "A2ATD1", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Kim J.I., De Robertis E.M., Li S.-Y., Brechner M., Martinez S.L., Pera E.M., Wessely O.", 
            "date": "2002"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/19874420", 
                    "type": "PubMed", 
                    "id": "19874420"
                }
            ], 
            "title": "Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumour growth in mice.", 
            "journal": "J. Cell. Mol. Med.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2ATD1", 
                    "id": "A2ATD1", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
                    "id": "NP_001263418.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Wang J., Wang Z., Yang H., Zhang Y., Irwan I.D., Ge R., Xiang W., Ke Z., Cheng G.H., Kini R.M., Potturi P., Sulochana K.N., Zhuo L.", 
            "date": "2011"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/20637190", 
                    "type": "PubMed", 
                    "id": "20637190"
                }
            ], 
            "title": "O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.", 
            "journal": "Developmental biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
                    "id": "NP_001263418.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M, Haltiwanger RS, Holdener BC", 
            "date": "2010"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24675886", 
                    "type": "PubMed", 
                    "id": "24675886"
                }
            ], 
            "title": "Distinct spatiotemporal expression of ISM1 during mouse and chick development.", 
            "journal": "Cell cycle (Georgetown, Tex.)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
                    "id": "NP_001263418.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Osorio L, Wu X, Zhou Z", 
            "date": "2014"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24956034", 
                    "type": "PubMed", 
                    "id": "24956034"
                }
            ], 
            "title": "Isthmin 1 is a secreted protein expressed in skin, mucosal tissues, and NK, NKT, and th17 cells.", 
            "journal": "Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
                    "id": "NP_001263418.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Valle-Rios R, Maravillas-Montero JL, Burkhardt AM, Martinez C, Buhren BA, Homey B, Gerber PA, Robinson O, Hevezi P, Zlotnik A", 
            "date": "2014"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/25952901", 
                    "type": "PubMed", 
                    "id": "25952901"
                }
            ], 
            "title": "Isthmin is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation.", 
            "journal": "Cardiovascular research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
                    "id": "NP_001263418.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Venugopal S, Chen M, Liao W, Er SY, Wong WS, Ge R", 
            "date": "2015"
        }
    ], 
    "uniprot_ac": "A2ATD1", 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ATD1", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Ism1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ATD1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "5430433G21Rik; Ism"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ATD1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Ism1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ATD1", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Ism"
        }
    ], 
    "reactions": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ATD1#A2ATD1-1", 
            "isoform_ac": "A2ATD1-1", 
            "locus": {
                "end_pos": 139520590, 
                "strand": "-", 
                "start_pos": 139599411, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000099307", 
                        "id": "ENSMUST00000099307", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000096910", 
                        "id": "ENSMUSP00000096910", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2ATD1-1|ISM1_MOUSE Isoform 1 of Isthmin-1  OS=Mus musculus OX=10090 GN=Ism1 PE=1 SV=1 CANONICAL=A2ATD1-1", 
                "length": 454, 
                "sequence": "MVRLAAELLLLLGLLLLTLHITVLRGSGASDRQDAAAGNNNLNLESDSTSETSFPLSKEAPEEHQVVHQPFPRQRFPPETGHPSLQRDGPRSFLLDLPNFPDLSKADINGQNPNIQVTIEVVDGPDSEAEKDQHPENKPSWSLPAPDWRAWWQRSLSLARTNSGDQDDKYDSTSDDSNFLSVPRGWDRPAPGHRTFETKEQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACIATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDMDSCERWMSCKSEFLKKYMHKVINDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ATD1#V9GXR4-1", 
            "isoform_ac": "V9GXR4-1", 
            "locus": {
                "end_pos": 139520590, 
                "strand": "-", 
                "start_pos": 139599411, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000184404", 
                        "id": "ENSMUST00000184404", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000139280", 
                        "id": "ENSMUSP00000139280", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|V9GXR4-1|V9GXR4_MOUSE Computationally mapped isoform of Isthmin-1  OS=Mus musculus OX=10090 GN=Ism1 PE=3 SV=1 CANONICAL=A2ATD1-1", 
                "length": 461, 
                "sequence": "MVRLAAELLLLLGLLLLTLHITVLRGSGASDRQDAAAGNVSGSQLQNNLNLESDSTSETSFPLSKEAPEEHQVVHQPFPRQRFPPETGHPSLQRDGPRSFLLDLPNFPDLSKADINGQNPNIQVTIEVVDGPDSEAEKDQHPENKPSWSLPAPDWRAWWQRSLSLARTNSGDQDDKYDSTSDDSNFLSVPRGWDRPAPGHRTFETKEQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACIATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDMDSCERWMSCKSEFLKKYMHKVINDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:319909", 
            "resource": "KEGG Pathway", 
            "id": "mmu:319909", 
            "name": ""
        }
    ], 
    "reaction_participants": [], 
    "function": [
        {
            "annotation": "Acts as an angiogenesis inhibitor.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2ATD1#function", 
                    "id": "A2ATD1", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "annotation": "Given that ISM1 has been reported to have anti-angiogenic properties, these observations suggest that ISM1 is a mediator of lymphocyte effector functions and may participate in both innate and acquired immune responses.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
                    "id": "NP_001263418.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "annotation": "ISM is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation as well as induction of apoptosis", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
                    "id": "NP_001263418.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "annotation": "ISM1 transcripts are found in tissues as the anterior mesendoderm, paraxial and lateral plate mesoderm, MHB and trunk neural tube, as well as in the somites and dermomyotome. In the newborn and adult, ISM1 is prominently expressed in the lung and brain.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
                    "id": "NP_001263418.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "annotation": "Results demonstrate that Isthmin is a novel endogenous angiogenesis inhibitor with functions likely in physiological as well as pathological angiogenesis.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
                    "id": "NP_001263418.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "B1AKI9-1", 
            "protein_name": "Isthmin-1", 
            "sequence": {
                "length": 464, 
                "sequence": "MVRLAAELLLLLGLLLLTLHITVLRGSGAADGPDAAAGNASQAQLQNNLNVGSDTTSETSFSLSKEAPREHLDHQAAHQPFPRPRFRQETGHPSLQRDFPRSFLLDLPNFPDLSKADINGQNPNIQVTIEVVDGPDSEADKDQHPENKPSWSVPSPDWRAWWQRSLSLARANSGDQDYKYDSTSDDSNFLNPPRGWDHTAPGHRTFETKDQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACTATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDTDSCERWMSCKSEFLKKYMHKVMNDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/19061", 
                    "id": "19061", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "ISM1", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
        "ac": "NP_001263418.1", 
        "name": "isthmin-1 precursor", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ATD1", 
                                "id": "A2ATD1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular region", 
                        "id": "GO:0005576"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016525", 
                        "pmid": "19874420", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ATD1", 
                                "id": "A2ATD1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of angiogenesis", 
                        "id": "GO:0016525"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 277, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 275
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000074766", 
            "id": "ENSMUSG00000074766", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/319909", 
            "id": "319909", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000884", 
            "id": "IPR000884", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR005533", 
            "id": "IPR005533", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036383", 
            "id": "IPR036383", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR042413", 
            "id": "IPR042413", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:319909", 
            "id": "mmu:319909", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:2442963", 
            "id": "2442963", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/EGDWSNW/", 
            "id": "EGDWSNW", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=876510at2759", 
            "id": "876510at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10239:SF30", 
            "id": "PTHR10239:SF30", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00090", 
            "id": "PF00090", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF03782", 
            "id": "PF03782", 
            "database": "Pfam"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A2ATD1", 
            "id": "PR_A2ATD1", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418", 
            "id": "NP_001263418", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ATD1", 
            "id": "A2ATD1", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ATD1-1", 
            "id": "A2ATD1-1", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/V9GXR4", 
            "id": "V9GXR4", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/V9GXR4-1", 
            "id": "V9GXR4-1", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 51145.0, 
        "chemical_mass": 51145.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ATD1", 
            "name": "Ism1", 
            "locus": {
                "end_pos": 139758581, 
                "strand": "+", 
                "start_pos": 139678178, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000074766", 
                        "id": "ENSMUSG00000074766", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ATD1#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Isthmin-1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ATD1#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Isthmin-1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ATD1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "isthmin 1 homolog"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ATD1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "isthmin-1 precursor"
        }
    ]
}